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Prediction of GO:0000026 "alpha-1,2-mannosyltransferase activity"

GO branch: MF
Number of currently annotated genes: 6

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest Harbison:CBF1_SMHuh:vacuoleKumar:nuclear rimHarbison:RTG3_H2O2HiKumar:ERIPR002685Harbison:TEC1_YPDPF01793Harbison:GAL4_RAFFIPR001296 S000000314ALG1YBR110WverifiedMannosyltransferase, involved in asparagine-linkedglycosylation in the endoplasmic reticulum(ER); essential for viability, mutation isfunctionally complemented by human ortholog 0.092810.7924&radic S000005163ALG9YNL219CverifiedMannosyltransferase, involved in N-linked glycosylation;catalyzes the transfer of mannose fromDol-P-Man to lipid-linked oligosaccharides;mutation of the human ortholog causes type 1congenital disorders of glycosylation 0.034720.57495 S000005974KTR6YPL053CverifiedProbable mannosylphosphate transferase involved in thesynthesis of core oligosaccharides in proteinglycosylation pathway; member of the KRE2/MNT1mannosyltransferase family 0.034280.57065&radic&radic&radic&radic&radic S000005313ALG12YNR030WverifiedAlpha-1,6-mannosyltransferase localized to the ER; responsiblefor the addition of the alpha-1,6 mannose todolichol-linked Man7GlcNAc2, acts in thedolichol pathway for N-glycosylation 0.030520.54508&radic&radic S000006096SPT14YPL175WverifiedUDP-GlcNAc-binding and catalytic subunit of the enzyme thatmediates the first step inglycosylphosphatidylinositol (GPI)biosynthesis, mutations cause defects intranscription and in biogenesis of cell wallproteins 0.030270.54445&radic S000003110GPI10YGL142CverifiedIntegral membrane protein involved inglycosylphosphatidylinositol (GPI) anchorsynthesis; putative alpha 1,2mannosyltransferase required for addition ofthe third mannose onto the GPI core structure;human PIG-Bp is a functional homolog 0.030290.54445 S000003033ALG2YGL065CverifiedPresumed early mannosyltransferase involved in the N-linkedglycosylation pathway; alg2 mutants exhibittemperature-sensitive growth and abnormalaccumulation of the lipid-linkedoligosaccharide Man2GlcNAc2-PP-Dol 0.027070.52367&radic S000000403KTR4YBR199WverifiedPutative mannosyltransferase involved in protein glycosylation;member of the KRE2/MNT1 mannosyltransferasefamily 0.026840.52248&radic&radic&radic S000000409KTR3YBR205WverifiedPutative alpha-1,2-mannosyltransferase involved in O- andN-linked protein glycosylation; member of theKRE2/MNT1 mannosyltransferase family 0.024070.5&radic&radic&radic S000005625KTR1YOR099WverifiedAlpha-1,2-mannosyltransferase involved in O- and N-linkedprotein glycosylation; member of the KRE2/MNT1mannosyltransferase family &radic0.019410.45537&radic&radic&radic&radic&radic&radic S000001069RPN1YHR027CverifiedNon-ATPase base subunit of the 19S regulatory particle of the26S proteasome; may participate in therecognition of several ligands of theproteasome; contains a leucine-rich repeat(LRR) domain, a site for protein?proteininteractions 0.018790.44395&radic&radic&radic&radic&radic&radic S000003675YUR1YJL139CverifiedMannosyltransferase of the KTR1 family, involved in proteinN-glycosylation; located in the Golgi apparatus 0.017630.4308&radic&radic S000001769KTR2YKR061WverifiedMannosyltransferase involved in N-linked protein glycosylation;member of the KRE2/MNT1 mannosyltransferasefamily 0.016480.42177&radic&radic&radic S000001347KTR7YIL085CverifiedPutative mannosyltransferase involved in protein glycosylation;member of the KRE2/MNT1 mannosyltransferasefamily 0.016460.42177&radic&radic S000004974KTR5YNL029CverifiedPutative mannosyltransferase involved in protein glycosylation;member of the KRE2/MNT1 mannosyltransferasefamily 0.016540.42177&radic&radic S000002891KRE2YDR483WverifiedAlpha1,2-mannosyltransferase of the Golgi involved in proteinmannosylation &radic0.014510.39185&radic&radic&radic&radic&radic S000005854SNC2YOR327CverifiedVesicle membrane receptor protein (v-SNARE) involved in thefusion between Golgi-derived secretory vesicleswith the plasma membrane; member of thesynaptobrevin/VAMP family of R-type v-SNAREproteins 0.011240.35159&radic&radic&radic&radic S000003006OCH1YGL038CverifiedMannosyltransferase of the cis-Golgi apparatus, initiates thepolymannose outer chain elongation of N-linkedoligosaccharides of glycoproteins 0.010240.33394&radic&radic&radic S000003694CIS3YJL158CverifiedMannose-containing glycoprotein constituent of the cell wall;member of the PIR (proteins with internalrepeats) family 0.009080.31236&radic&radic&radic&radic S000004145ASP3-1YLR155CverifiedCell-wall L-asparaginase II, involved in asparagine catabolism;expression is induced during nitrogenstarvation; four copies of ASP3 are present inthe genome reference strain S288C 0.00880.30723&radic&radic&radic S000002279YDL121CUncharacterizedHypothetical protein 0.007720.28496&radic&radic S000004810VTI1YMR197CverifiedProtein involved in cis-Golgi membrane traffic; v-SNARE thatinteracts with two t-SNARES, Sed5p and Pep12p;required for multiple vacuolar sorting pathways 0.007110.27308&radic&radic&radic S000002210SLC1YDL052Cverified1-acyl-sn-gylcerol-3-phosphate acyltransferase, catalyzes theacylation of lysophosphatidic acid to formphosphatidic acid, a key intermediate in lipidmetabolism; located in lipid particles andendoplasmic reticulum 0.007010.27041&radic&radic&radic S000002831CAD1YDR423CverifiedAP-1-like bZIP transcriptional activator involved in multiplestress responses, iron metabolism, andpleiotropic drug resistance; controls a set ofgenes involved in stabilizing proteins, bindsconsensus sequence TTACTAA; 5' UTR containsuORFs 0.006640.26331&radic&radic S000000664ATG15YCR068WverifiedLipase, required for intravacuolar lysis of autophagic bodies;located in the endoplasmic reticulum membraneand targeted to intravacuolar vesicles duringautophagy via the multivesicular body (MVB)pathway 0.006430.26048&radic&radic S000000116RFT1YBL020WverifiedFlippase, essential integral membrane protein that is requiredfor translocation of Man5GlcNac2-PP-Dol fromthe cytoplasmic side to the lumenal side of theER membrane; mutation is suppressed byexpression human p53 protein 0.004790.21428&radic S000000563FYV5YCL058CdubiousProtein of unknown function, required for survival uponexposure to K1 killer toxin; involved in ionhomeostasis 0.004550.21061&radic S000004394YLR402WDubiousHypothetical protein 0.004550.21061&radic S000001702COS9YKL219WverifiedProtein of unknown function, member of the DUP380 subfamily ofconserved, often subtelomerically-encodedproteins 0.004240.20575&radic&radic S000002321YDL162CDubiousHypothetical protein 0.004240.20575&radic S000002208YDL050CDubiousHypothetical protein 0.004240.20575&radic S000000683YCR087WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene 0.004110.20249&radic S000005263YNL319WDubiousDubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14 0.004110.20249&radic S000005725YOR199WDubiousHypothetical protein 0.004110.20249&radic S000001316YIL054WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data 0.004110.20249&radic S000005726YOR200WDubiousHypothetical protein 0.004110.20249&radic S000001172YHR130CDubiousHypothetical protein 0.004110.20249&radic S000002254OPI6YDL096CdubiousDubious open reading frame unlikely to encode a protein, basedon available experimental and comparativesequence data; partially overlaps verified genePMT1/YDL095W; YDL096C is not essential 0.004110.20249&radic S000000231YBR027CDubiousHypothetical protein 0.004110.20249&radic&radic S000002184YDL026WDubiousHypothetical protein 0.004110.20249&radic S000000528YCL023CDubiousHypothetical protein 0.004110.20249&radic S000003600YJL064WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1 0.004110.20249&radic S000000527YCL022CDubiousHypothetical protein 0.004110.20249&radic S000004330OPI9YLR338WdubiousDubious open reading frame unlikely to encode a protein, basedon available experimental and comparativesequence data; partially overlaps the verifiedORF VRP1/YLR337C 0.004110.20249&radic S000004242YLR252WDubiousHypothetical protein 0.004080.19763&radic S000002415YDR008CDubiousHypothetical protein 0.004080.19763&radic S000004066YLR076CDubiousHypothetical protein; open reading frame overlaps essential RPL10 gene encoding the ribosomal protein L10 which is a component of the large (60S) ribosomal subunit and responsible for joining the large and small subunits 0.004080.19763&radic S000003705YJL169WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2 0.004080.19763&radic S000002809YDR401WDubiousHypothetical protein 0.004080.19763&radic S000003182YGL214WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion mutation phenotype is likely due to the overlapping verified ORF SKI8/YGL213C 0.004080.19763&radic S000000570YCL065WDubiousHypothetical protein 0.004080.19763&radic S000002417YDR010CDubiousHypothetical protein 0.004080.19763&radic S000000633PHO87YCR037CverifiedLow-affinity inorganic phosphate (Pi) transporter, involved inactivation of PHO pathway; expression isindependent of Pi concentration and Pho4pactivity; contains 12 membrane-spanningsegments 0.00270.15565&radic&radic&radic S000004071GAL2YLR081WverifiedGalactose permease, required for utilization of galactose; alsoable to transport glucose 0.002540.15565&radic&radic S000000667IMG2YCR071CverifiedMitochondrial ribosomal protein of the small subunit 0.002680.15565&radic&radic&radic S000003723SWE1YJL187CverifiedProtein kinase that regulates the G2/M transition by inhibitionof Cdc28p kinase activity; localizes to thenucleus and to the daughter side of themother-bud neck; homolog of S. pombe Wee1p;potential Cdc28p substrate 0.002560.15565&radic&radic&radic S000000243ATP3YBR039WverifiedGamma subunit of the F1 sector of mitochondrial F1F0 ATPsynthase, which is a large, evolutionarilyconserved enzyme complex required for ATPsynthesis 0.002450.15139&radic&radic S000004393DUS3YLR401CuncharacterizedDihydrouridine synthase, member of a widespread family ofconserved proteins including Smm1p, Dus1p, andDus4p; contains a consensus oleate responseelement (ORE) in its promoter region 0.002230.1403&radic S000000704AAD3YCR107WverifiedPutative aryl-alcohol dehydrogenase with similarity to P.chrysosporium aryl-alcohol dehydrogenase;mutational analysis has not yet revealed aphysiological role 0.002020.13208&radic&radic S000006219YPR015CUncharacterizedPutative protein of unknown function 0.001990.13208&radic S000004240SSP120YLR250WverifiedProtein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to the cytoplasmin a punctate pattern 0.001990.13208&radic S000001526PHD1YKL043WverifiedTranscriptional activator that enhances pseudohyphal growth;regulates expression of FLO11, an adhesinrequired for pseudohyphal filament formation;similar to StuA, an A. nidulans developmentalregulator; potential Cdc28p substrate 0.002060.13208&radic S000003664PBS2YJL128CverifiedMAP kinase kinase that plays a pivotal role in the osmosensingsignal-transduction pathway, activated undersevere osmotic stress 0.002120.13208&radic S000004431MRPL4YLR439WverifiedMitochondrial ribosomal protein of the large subunit 0.002110.13208&radic S000000070ADE1YAR015WverifiedN-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR)synthetase, required for 'de novo' purinenucleotide biosynthesis; red pigmentaccumulates in mutant cells deprived of adenine 0.002140.13208&radic S000005645RIO1YOR119CverifiedEssential serine kinase involved in cell cycle progression andprocessing of the 20S pre-rRNA into mature 18SrRNA 0.002020.13208&radic S000002302CCT4YDL143WverifiedSubunit of the cytosolic chaperonin Cct ring complex, relatedto Tcp1p, required for the assembly of actinand tubulins in vivo 0.002030.13208&radic S000003669MRS3YJL133WverifiedMitochondrial iron transporter of the mitochondrial carrierfamily (MCF), very similar to and functionallyredundant with Mrs4p; functions under low-ironconditions; may transport other cations inaddition to iron 0.0020.13208&radic&radic S000002414TRP1YDR007WverifiedPhosphoribosylanthranilate isomerase that catalyzes the thirdstep in tryptophan biosynthesis; in 2004, thesequence of TRP1 from strain S228C was updatedby changing the previously annotated internalSTOP (TAA) to serine (TCA) 0.001980.13047&radic S000002444KRS1YDR037WverifiedLysyl-tRNA synthetase; also identified as a negative regulatorof general control of amino acid biosynthesis 0.001960.13047&radic S000000210UGA2YBR006WverifiedSuccinate semialdehyde dehydrogenase involved in theutilization of gamma-aminobutyrate (GABA) as anitrogen source; part of the 4-aminobutyrateand glutamate degradation pathways; localizedto the cytoplasm 0.001970.13047&radic S000002637IVY1YDR229WverifiedPhospholipid-binding protein that interacts with both Ypt7p andVps33p, may partially counteract the action ofVps33p and vice versa, localizes to the rim ofthe vacuole as cells approach stationary phase 0.001850.12676&radic S000000230ETR1YBR026Cverified2-enoyl thioester reductase, member of the medium chaindehydrogenase/reductase family; localized to inmitochondria, where it has a probable role infatty acid synthesis 0.001870.12676&radic&radic S000000663SED4YCR067CverifiedIntegral endoplasmic reticulum membrane protein, functions as apositive regulator of Sar1p probably throughinhibition of GTPase activation by Sec23p;binds Sec16p, participates in vesicleformation, similar to Sec12p 0.001910.12676&radic S000006373JIP5YPR169WuncharacterizedNucleolar protein of unknown function, exhibits a physicalinteraction with Bre1p 0.001920.12676&radic S000000458TRS20YBR254CverifiedOne of 10 subunits of the transport protein particle (TRAPP)complex of the cis-Golgi which mediates vesicledocking and fusion; mutations in the humanhomolog cause the spondyloepiphyseal dysplasiatarda (SEDL) disorder 0.001890.12676&radic S000002782YDR374CUncharacterizedHypothetical protein 0.001890.12676&radic S000002764SPC110YDR356WverifiedInner plaque spindle pole body (SPB) component, ortholog ofhuman kendrin; involved in connecting nuclearmicrotubules to SPB; interacts withTub4p-complex and calmodulin; phosphorylated byMps1p in cell cycle-dependent manner 0.001880.12676&radic&radic&radic S000000102LDB7YBL006CverifiedComponent of the RSC chromatin remodeling complex; interactswith Rsc3p, Rsc30p, Npl6p, and Htl1p to form amodule important for a broad range of RSCfunctions 0.001930.12676&radic S000003064TOS8YGL096WverifiedHomeodomain-containing transcription factor; SBF regulatedtarget gene that in turn regulates expressionof genes involved in G1/S phase events such asbud site selection, bud emergence and cellcycle progression; similarity to Cup9p 0.001920.12676&radic S000000222GAL7YBR018CverifiedGalactose-1-phosphate uridyl transferase, synthesizesglucose-1-phosphate and UDP-galactose fromUDP-D-glucose and alpha-D-galactose-1-phosphatein the second step of galactose catabolism 0.001930.12676&radic S000002185YDL027CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; YDL027C is not an essential gene 0.001850.12676&radic S000007522YBR085C-AUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus 0.001910.12676&radic S000000003EFB1YAL003WverifiedTranslation elongation factor 1 beta; stimulates nucleotideexchange to regenerate EF-1 alpha-GTP for thenext elongation cycle; part of the EF-1complex, which facilitates binding ofaminoacyl-tRNA to the ribosomal A site 0.001890.12676&radic S000001308MET30YIL046WverifiedF-box protein containing five copies of the WD40 motif,controls cell cycle function, sulfurmetabolism, and methionine biosynthesis as partof the ubiquitin ligase complex; interacts withand regulates Met4p, localizes within thenucleus 0.001910.12676&radic S000003102PCL10YGL134WverifiedPho85p cyclin; recruits, activates, and targets Pho85pcyclin-dependent protein kinase to itssubstrate 0.001910.12676&radic S000001052RPL27AYHR010WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl27Bp and has similarity to ratL27 ribosomal protein 0.001940.12676&radic&radic S000001051YHR009CUncharacterizedPutative protein of unknown function; not an essential gene 0.001930.12676&radic&radic S000002390BRE4YDL231CverifiedZinc finger protein containing five transmembrane domains; nullmutant exhibits strongly fragmented vacuolesand sensitivity to brefeldin A, a drug which isknown to affect intracellular transport 0.001870.12676&radic S000003107FLC3YGL139WverifiedPutative FAD transporter, similar to Flc1p and Flc2p; localizedto the ER 0.001870.12676&radic S000000117HAP3YBL021CverifiedSubunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5pCCAAT-binding complex, a transcriptionalactivator and global regulator of respiratorygene expression; contains sequencescontributing to both complex assembly and DNAbinding 0.001870.12676&radic S000002744YDR336WUncharacterizedPutative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene 0.00190.12676&radic&radic&radic&radic S000000460RIB5YBR256CverifiedRiboflavin synthase; catalyzes the last step of the riboflavinbiosynthesis pathway 0.001930.12676&radic S000000459YBR255WUncharacterizedProtein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.001820.1192&radic S000000702ADH7YCR105WverifiedNADPH-dependent cinnamyl alcohol dehydrogenase family memberwith broad substrate specificity; may beinvolved in fusel alcohol synthesis 0.001720.1192&radic&radic S000000089YAR064WUncharacterizedPutative protein of unknown function 0.001690.1192&radic S000002389PTP1YDL230WverifiedPhosphotyrosine-specific protein phosphatase thatdephosphorylates a broad range of substrates invivo, including Fpr3p; localized to thecytoplasm and the mitochondria 0.00170.1192&radic S000000829GAL83YER027CverifiedOne of three possible beta-subunits of the Snf1 kinase complex,allows nuclear localization of the Snf1 kinasecomplex in the presence of a nonfermentablecarbon source; contains glycogen-binding domain 0.001770.1192&radic S000000048OAF1YAL051WverifiedOleate-activated transcription factor, acts alone and as aheterodimer with Pip2p; activates genesinvolved in beta-oxidation of fatty acids andperoxisome organization and biogenesis 0.001690.1192&radic S000002636PCF11YDR228CverifiedmRNA 3' end processing factor, essential component of cleavageand polyadenylation factor IA (CF IA), involvedin pre-mRNA 3' end processing and intranscription termination; binds C-terminaldomain of largest subunit of RNA pol II(Rpo21p) 0.00170.1192&radic S000000069BUD14YAR014CverifiedProtein involved in bud-site selection, Bud14p-Glc7p complexfunctions as a cortical regulator of dynein;diploid mutants display a random buddingpattern instead of the wild-type bipolarpattern 0.001770.1192&radic S000006105MRN1YPL184CuncharacterizedPutative RNA binding protein 0.00170.1192&radic S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.001790.1192&radic S000002936HLR1YDR528WverifiedProtein involved in regulation of cell wall composition andintegrity and response to osmotic stress;overproduction suppresses a lysis sensitive PKCmutation; similar to Lre1p, which functionsantagonistically to protein kinase A 0.001760.1192&radic S000000056BDH1YAL060WverifiedNAD-dependent (2R,3R)-2,3-butanediol dehydrogenase, azinc-containing medium-chain alcoholdehydrogenase, produces 2,3-butanediol fromacetoin during fermentation and allows using2,3-butanediol as a carbon source duringaerobic growth 0.001690.1192&radic S000000076YAR028WUncharacterizedPutative integral membrane protein, member of DUP240 gene family 0.001780.1192&radic S000002285PCL2YDL127WverifiedG1 cyclin, associates with Pho85p cyclin-dependent kinase (Cdk)to contribute to entry into the mitotic cellcycle, essential for cell morphogenesis;localizes to sites of polarized cell growth 0.001710.1192&radic&radic S000004516SUR7YML052WverifiedPutative integral membrane protein; component of eisosomes;associated with endocytosis, along with Pil1pand Lsp1p; sporulation and plasma membranesphingolipid content are altered in mutants 0.001770.1192&radic S000001305CBR1YIL043CverifiedMicrosomal cytochrome b reductase, not essential for viability;also detected in mitochondria; mutation inconserved NADH binding domain of the humanortholog results in type I methemoglobinemia 0.001680.1192&radic S000002685MTH1YDR277CverifiedNegative regulator of the glucose-sensing signal transductionpathway, required for repression oftranscription by Rgt1p; interacts with Rgt1pand the Snf3p and Rgt2p glucose sensors;phosphorylated by Yck1p, triggering Mth1pdegradation 0.00180.1192&radic S000002996SCW11YGL028CverifiedCell wall protein with similarity to glucanases; may play arole in conjugation during mating based on itsregulation by Ste12p 0.001680.1192&radic S000000226POA1YBR022WverifiedPhosphatase that is highly specific for ADP-ribose1''-phosphate, a tRNA splicing metabolite; mayhave a role in regulation of tRNA splicing 0.001810.1192&radic S000003697FMP33YJL161WuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.00170.1192&radic S000004241SYM1YLR251WuncharacterizedProtein required for ethanol metabolism; induced by heat shockand localized to the inner mitochondrialmembrane; homologous to mammalian peroxisomalmembrane protein Mpv17 0.001720.1192&radic S000002412MAF1YDR005CverifiedNegative regulator of RNA polymerase III; component of severalsignaling pathways that repress polymerase IIItranscription in response to changes incellular environment; targets the initiationfactor TFIIIB 0.001840.1192&radic S000001334HOP1YIL072WverifiedMeiosis-specific DNA binding protein that displays Red1pdependent localization to the unsynapsedaxial-lateral elements of the synaptonemalcomplex; required for homologous chromosomesynapsis and chiasma formation 0.001720.1192&radic S000000111ACH1YBL015WverifiedAcetyl-coA hydrolase, primarily localized to mitochondria;required for acetate utilization and fordiploid pseudohyphal growth 0.001790.1192&radic S000002443EHD3YDR036CverifiedProtein of unconfirmed function, plays an indirect role inendocytic membrane trafficking, member of afamily of enoyl-CoA hydratase/isomerases; thenon-tagged protein is detected in highlypurified mitochondria in high-throughputstudies 0.001810.1192&radic S000000218YBR014CUncharacterizedHypothetical protein 0.001750.1192&radic&radic S000000456DUT1YBR252WverifieddUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, therebypreventing incorporation of uracil into DNAduring replication; critical for themaintenance of genetic stability 0.00170.1192&radic S000006093COX10YPL172CverifiedHeme A:farnesyltransferase, catalyzes the first step in theconversion of protoheme to the heme Aprosthetic group required for cytochrome coxidase activity; human ortholog is associatedwith mitochondrial disorders 0.001690.1192&radic S000000002VPS8YAL002WverifiedMembrane-associated hydrophilic protein that interacts with thesmall GTPase, Vps21p, to facilitate solublevacuolar protein localization; required forlocalization and trafficking of the CPY sortingreceptor; contains a RING finger motif 0.001680.1192&radic S000005782TRE2YOR256CverifiedProtein of unknown function with similarity to TRE1/YPL176C;required for cell viability 0.00170.1192&radic S000001259IMD2YHR216WverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, expression is induced bymycophenolic acid resulting in resistance tothe drug, expression is repressed by nutrientlimitation 0.001830.1192&radic S000000123RPL19BYBL027WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl19Ap and has similarity to ratL19 ribosomal protein; rpl19a and rpl19b singlenull mutations result in slow growth, while thedouble null mutation is lethal 0.001790.1192&radic S000005017MSK1YNL073WverifiedMitochondrial lysine-tRNA synthetase, required for import ofboth aminoacylated and deacylated forms oftRNA(Lys) into mitochondria 0.001750.1192&radic S000000025YAL027WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YAL027W is a non-essential gene 0.001810.1192&radic S000004632RSF1YMR030WverifiedProtein required for respiratory growth; localized to both thenucleus and mitochondrion; mutant displaysdecreased transcription of specific nuclear andmitochondrial genes whose products are involvedin respiratory growth 0.001670.1192&radic S000000101PDR3YBL005WverifiedTranscriptional activator of the pleiotropic drug resistancenetwork, regulates expression of ATP-bindingcassette (ABC) transporters through binding tocis-acting sites known as PDREs (PDR responsiveelements) 0.001690.1192&radic S000001258PHO12YHR215WverifiedOne of three repressible acid phosphatases, a glycoprotein thatis transported to the cell surface by thesecretory pathway; nearly identical to Pho11p;upregulated by phosphate starvation 0.001750.1192&radic&radic S000000571HMLALPHA1YCL066WverifiedSilenced copy of ALPHA1 at HML, encoding a transcriptionalcoactivator involved in the regulation ofmating-type alpha-specific gene expression 0.001660.1192&radic S000003044RPL7AYGL076CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl7Bp and has similarity to E.coli L30 and rat L7 ribosomal proteins;contains a conserved C-terminal Nucleic acidBinding Domain (NDB2) 0.001720.1192&radic S000000562PRD1YCL057WverifiedZinc metalloendopeptidase, found in the cytoplasm andintermembrane space of mitochondria; withCym1p, involved in degradation of mitochondrialproteins and of presequence peptides cleavedfrom imported proteins 0.00180.1192&radic S000004517YML053CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YML053C is not an essential gene 0.001850.1192&radic S000004349RSC2YLR357WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; involvedin telomere maintenance 0.001820.1192&radic S000005646GCY1YOR120WverifiedPutative NADP(+) coupled glycerol dehydrogenase, proposed to beinvolved in an alternative pathway for glycerolcatabolism 0.001730.1192&radic S000005664RUP1YOR138CverifiedProtein involved in regulation of Rsp5p, which is an essentialHECT ubiquitin ligase; required for binding ofRsp5p to Ubp2p; contains an UBA domain 0.00170.1192&radic S000002303YDL144CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene. 0.001660.1192&radic S000004328SGD1YLR336CverifiedEssential nuclear protein with a possible role in theosmoregulatory glycerol response; interactswith phospholipase C (Plc1p); putative homologof human NOM1 which is implicated in acutemyeloid leukemia 0.001850.1192&radic S000000572HMLALPHA2YCL067CverifiedSilenced copy of ALPHA2 at HML; homeobox-domain protein thatassociates with Mcm1p in haploid cells torepress a-specific gene expression andinteracts with a1p in diploid cells to represshaploid-specific gene expression 0.001670.1192&radic S000003413TIM13YGR181WverifiedMitochondrial intermembrane space protein, forms a complex withTIm8p that mediates import and insertion of asubset of polytopic inner membrane proteins;may prevent aggregation of incoming proteins ina chaperone-like manner 0.001760.1192&radic&radic S000000783YEL057CUncharacterizedProtein of unknown function involved in telomere maintenance; target of UME6 regulation 0.001750.1192&radic S000004515GAL80YML051WverifiedTranscriptional regulator involved in the repression of GALgenes in the absence of galactose; inhibitstranscriptional activation by Gal4p; inhibitionrelieved by Gal3p or Gal1p binding 0.001740.1192&radic S000002186MPS1YDL028CverifiedDual-specificity kinase required for spindle pole body (SPB)duplication and spindle checkpoint function;substrates include SPB proteins Spc42p,Spc110p, and Spc98p, mitotic exit networkprotein Mob1p, and checkpoint protein Mad1p 0.001660.1192&radic S000003093MET13YGL125WverifiedIsozyme of methylenetetrahydrofolate reductase, catalyzes thereduction of 5,10-methylenetetrahydrofolate to5-methyltetrahydrofolate in the methioninebiosynthesis pathway 0.00180.1192&radic&radic S000002418SNQ2YDR011WverifiedABC transporter protein involved in multidrug resistance andresistance to singlet oxygen species 0.001770.1192&radic S000003602MPM1YJL066CverifiedMitochondrial membrane protein of unknown function, contains nohydrophobic stretches 0.00180.1192&radic S000005783CDC31YOR257WverifiedComponent of the spindle pole body (SPB) half-bridge, requiredfor SPB duplication in mitosis and meiosis II;homolog of mammalian centrin; interacts withKar1p 0.001830.1192&radic S000001309SYG1YIL047CverifiedPlasma membrane protein of unknown function; truncation andoverexpression suppresses lethality of G-alphaprotein deficiency 0.001680.1192&radic S000004072SRL2YLR082CverifiedProtein of unknown function; overexpression suppresses thelethality caused by a rad53 null mutation 0.001810.1192&radic S000000853JHD1YER051WverifiedJmjC domain family histone demethylase specific for H3-K36,similar to proteins found in human, mouse,drosophila, X. laevis, C. elegans, and S. pombe 0.001690.1192&radic S000000223GAL10YBR019CverifiedUDP-glucose-4-epimerase, catalyzes the interconversion ofUDP-galactose and UDP-D-glucose in galactosemetabolism; also catalyzes the conversion ofalpha-D-glucose or alpha-D-galactose to theirbeta-anomers 0.001770.1192&radic S000000298PBY1YBR094WuncharacterizedP-body associated protein 0.001830.1192&radic S000000241SCO1YBR037CverifiedCopper-binding protein of the mitochondrial inner membrane,required for cytochrome c oxidase activity andrespiration; may function to deliver copper tocytochrome c oxidase; has similarity tothioredoxins 0.001770.1192&radic S000001317YIL055CUncharacterizedHypothetical protein 0.00180.1192&radic S000004631FAR8YMR029CverifiedProtein involved in G1 cell cycle arrest in response topheromone, in a pathway different from theFar1p-dependent pathway; interacts with Far3p,Far7p, Far9p, Far10p, and Far11p 0.001670.1192&radic S000004070EMP46YLR080WverifiedIntegral membrane component of endoplasmic reticulum-derivedCOPII-coated vesicles, which function in ER toGolgi transport 0.001650.11873&radic&radic S000004630TAP42YMR028WverifiedEssential protein involved in the TOR signaling pathway;physically associates with the proteinphosphatase 2A and the SIT4 protein phosphatasecatalytic subunits 0.001650.11873&radic S000002741YDR333CUncharacterizedHypothetical protein 0.001640.11873&radic S000003749YJL213WUncharacterizedPutative protein of unknown function; periodically expressed during the yeast metabolic cycle; expression induced in respiratory incompetent petite cells; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p 0.001640.11873&radic S000001333PCI8YIL071CverifiedPossible shared subunit of Cop9 signalosome (CSN) and eIF3,binds eIF3b subunit Prt1p, has possible dualfunctions in transcriptional and translationalcontrol, contains a PCI (Proteasome-COP9signalosome (CSN)-eIF3) domain 0.001650.11873&radic S000005666SFL1YOR140WverifiedTranscription repressor involved in regulation offlocculation-related genes, inhibitstranscription by recruiting general corepressorCyc8p-Tup1p to different promoters; negativelyregulated by cAMP-dependent protein kinase Asubunit Tpk2p 0.001640.11873&radic S000000037CYC3YAL039CverifiedCytochrome c heme lyase (holocytochrome c synthase), attachesheme to apo-Cyc1p in the mitochondrialintermembrane space; human ortholog may have arole in microphthalmia with linear skin defects(MLS) 0.001650.11873&radic S000000221KAP104YBR017CverifiedTransportin, cytosolic karyopherin beta 2 involved in deliveryof heterogeneous nuclear ribonucleoproteins tothe nucleoplasm, binds rg-nuclear localizationsignals on Nab2p and Hrp1p, plays a role incell-cycle progression 0.001640.11873&radic S000003667YJL131CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria; YJL131C is a non-essential gene 0.001650.11873&radic S000001312PCL7YIL050WverifiedPho85p cyclin of the Pho80p subfamily, forms a functionalkinase complex with Pho85p which phosphorylatesMmr1p and is regulated by Pho81p; involved inglycogen metabolism, expression is cell-cycleregulated 0.001640.11873&radic S000000539LSB5YCL034WverifiedProtein of unknown function; binds Las17p, which is a homologof human Wiskott-Aldrich Syndrome proteininvolved in actin patch assembly and actinpolymerization 0.001540.11222&radic S000000078PRM9YAR031WverifiedPheromone-regulated protein with 3 predicted transmembranesegments and an FF sequence, a motif involvedin COPII binding; member of DUP240 gene family 0.001550.11222&radic S000000575YCL073CUncharacterizedProtein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YKR106W 0.001570.11222&radic S000003706ASG7YJL170CverifiedProtein that regulates signaling from a G protein beta subunitSte4p and its relocalization within the cell;specific to a-cells and induced by alpha-factor 0.00160.11222&radic S000000224GAL1YBR020WverifiedGalactokinase, phosphorylates alpha-D-galactose toalpha-D-galactose-1-phosphate in the first stepof galactose catabolism; expression regulatedby Gal4p 0.001580.11222&radic S000003743LAA1YJL207CverifiedProtein of unknown function, proposed to function as a largeAP-1 accessory protein; colocalizes withclathrin to the late-Golgi apparatus; YJL207Cis a non-essential gene 0.00150.11222&radic S000000036CDC19YAL038WverifiedPyruvate kinase, functions as a homotetramer in glycolysis toconvert phosphoenolpyruvate to pyruvate, theinput for aerobic (TCA cycle) or anaerobic(glucose fermentation) respiration 0.001610.11222&radic S000002416GAL3YDR009WverifiedTranscriptional regulator involved in activation of the GALgenes in response to galactose; forms a complexwith Gal80p to relieve Gal80p inhibition ofGal4p; binds galactose and ATP but does nothave galactokinase activity 0.001510.11222&radic S000001262YHR219WUncharacterizedPutative protein of unknown function with similarity to helicases; located in the telomere region on the right arm of chromosome VIII 0.001570.11222&radic S000000252RPS11BYBR048WverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps11Ap and has similarity to E.coli S17 and rat S11 ribosomal proteins 0.001480.11222&radic S000000225FUR4YBR021WverifiedUracil permease, localized to the plasma membrane; expressionis tightly regulated by uracil levels andenvironmental cues 0.001570.11222&radic S000001314RPL34BYIL052CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl34Ap and has similarity to ratL34 ribosomal protein 0.001630.11222&radic S000007496IGO2YHR132W-AuncharacterizedPutative protein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to the cytoplasmand nucleus 0.001590.11222&radic S000001335SPO22YIL073CverifiedMeiosis-specific protein essential for chromosome synapsis,similar to phospholipase A2, involved incompletion of nuclear divisions during meiosis;induced early in meiosis 0.001480.11222&radic S000000682CSM1YCR086WverifiedNucleolar protein that forms a complex with Lrs4p which bindsMam1p at kinetochores during meiosis I tomediate accurate chromosome segregation, may beinvolved in premeiotic DNA replication;possible role in telomere maintenance 0.00150.11222&radic S000000004SSA1YAL005CverifiedATPase involved in protein folding and nuclear localizationsignal (NLS)-directed nuclear transport; memberof heat shock protein 70 (HSP70) family; formsa chaperone complex with Ydj1p; localized tothe nucleus, cytoplasm, and cell wall 0.001520.11222&radic S000002413SOK1YDR006CverifiedProtein whose overexpression suppresses the growth defect ofmutants lacking protein kinase A activity;involved in cAMP-mediated signaling; localizedto the nucleus; similar to the mousetestis-specific protein PBS13 0.00160.11222&radic S000001173YHR131CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.001580.11222&radic S000004067FMP25YLR077WuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.001530.11222&radic S000001313MMF1YIL051CverifiedMitochondrial protein involved in maintenance of themitochondrial genome 0.001520.11222&radic S000000059FLO9YAL063CverifiedLectin-like protein with similarity to Flo1p, thought to beexpressed and involved in flocculation 0.001490.11222&radic S000000122LSM2YBL026WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.001480.11222&radic S000001340THS1YIL078WverifiedThreonyl-tRNA synthetase, essential cytoplasmic protein 0.001530.11222&radic S000000208GPI18YBR004CverifiedFunctional ortholog of human PIG-V, which is amannosyltransferase that transfers the secondmannose in glycosylphosphatidylinositolbiosynthesis; the authentic, non-tagged proteinwas localized to mitochondria 0.001610.11222&radic S000000782HAT2YEL056WverifiedSubunit of the Hat1p-Hat2p histone acetyltransferase complex;required for high affinity binding of thecomplex to free histone H4, thereby enhancingHat1p activity; similar to human RbAp46 and 48;has a role in telomeric silencing 0.001620.11222&radic S000001341AIR1YIL079CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p to regulate methylationof Npl3p, which modulates Npl3p function inmRNA processing and export; has similarity toAir2p 0.001460.11222&radic S000000209RCR1YBR005WverifiedProtein of the endoplasmic reticulum membrane involved inchitin deposition in the cell wall;overproduction confers resistance to Congo Red 0.001540.11222&radic S000000499PCA1YBR295WverifiedCadmium transporting P-type ATPase; may also have a role incopper and iron homeostasis; S288C and mostother lab strains contain a G970R mutationwhich eliminates normal cadmium transportfunction 0.001610.11222&radic S000000490APE3YBR286WverifiedVacuolar aminopeptidase Y, processed to mature form by Prb1p 0.001620.11222&radic S000002211PBP4YDL053CverifiedPbp1p binding protein, interacts strongly with Pab1p-bindingprotein 1 (Pbp1p) in the yeast two-hybridsystem; also interacts with Lsm12p in acopurification assay 0.001590.11222&radic S000000297PHO5YBR093CverifiedRepressible acid phosphatase (1 of 3) that also mediatesextracellular nucleotide-derived phosphatehydrolysis; secretory pathway derived cellsurface glycoprotein; induced by phosphatestarvation and coordinately regulated by PHO4and PHO2 0.001590.11222&radic&radic S000000229YBR025CUncharacterizedHypothetical protein 0.001610.11222&radic S000005724BFR1YOR198CverifiedComponent of mRNP complexes associated with polyribosomes;implicated in secretion and nuclearsegregation; multicopy suppressor of BFA(Brefeldin A) sensitivity 0.001610.11222&radic S000000013NTG1YAL015CverifiedDNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involvedin base excision repair, localizes to thenucleus and mitochondrion 0.001590.11222&radic S000000852RSM18YER050CverifiedMitochondrial ribosomal protein of the small subunit, hassimilarity to E. coli S18 ribosomal protein 0.001550.11222&radic S000001694TRP3YKL211CverifiedBifunctional enzyme exhibiting both indole-3-glycerol-phosphatesynthase and anthranilate synthase activities,forms multifunctional hetero-oligomericanthranilate synthase:indole-3-glycerolphosphate synthase enzyme complex with Trp2p 0.001480.11222&radic S000002251PMT5YDL093WverifiedProtein O-mannosyltransferase, transfers mannose residues fromdolichyl phosphate-D-mannose to proteinserine/threonine residues; acts in a complexwith Pmt3p, can instead interact with Pmt2p insome conditions; target for new antifungals 0.001630.11222&radic S000000489YBR285WUncharacterizedPutative protein of unknown function; YBR285W is not an essential gene and deletion of YBR285W leads to poor growth on glucose-minimal medium at 15C 0.001540.11222&radic S000000242CHS2YBR038WverifiedChitin synthase II, requires activation from zymogenic form inorder to catalyze the transfer ofN-acetylglucosamine (GlcNAc) to chitin;required for the synthesis of chitin in theprimary septum during cytokinesis 0.001570.11222&radic S000000058GDH3YAL062WverifiedNADP(+)-dependent glutamate dehydrogenase, synthesizesglutamate from ammonia and alpha-ketoglutarate;rate of alpha-ketoglutarate utilization differsfrom Gdh1p; expression regulated by nitrogenand carbon sources 0.001510.11222&radic&radic S000001292SSM4YIL030CverifiedUbiquitin-protein ligase of the ER/nuclear envelope, requiredfor degradation of Alpha2p and other proteinscontaining a Deg1 degradation signal; ssm4mutation suppresses mRNA instability caused byan rna14 mutation 0.00160.11222&radic S000000461POP4YBR257WverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends; binds to the RPR1 RNAsubunit in Rnase P 0.001570.11222&radic S000000220YBR016WUncharacterizedPlasma membrane protein of unknown function; has similarity to hydrophilins, which are hydrophilic, glycine-rich proteins involved in the adaptive response to hyperosmotic conditions 0.001560.11222&radic S000003693FAR1YJL157CverifiedCyclin-dependent kinase inhibitor that mediates cell cyclearrest in response to pheromone; also forms acomplex with Cdc24p, Ste4p, and Ste18p that mayspecify the direction of polarized growthduring mating; potential Cdc28p substrate 0.001620.11222&radic S000000677SRB8YCR081WverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation; involved in glucoserepression 0.00140.10937&radic S000005018MLF3YNL074CverifiedSerine-rich protein of unknown function; overproductionsuppresses the growth inhibition caused byexposure to the immunosuppressant leflunomide 0.001390.10937&radic S000001215SPC97YHR172WverifiedComponent of the microtubule-nucleating Tub4p (gamma-tubulin)complex; interacts with Spc110p at the spindlepole body (SPB) inner plaque and with Spc72p atthe SPB outer plaque 0.001450.10937&radic S000002198NAT1YDL040CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.00140.10937&radic S000003108YGL140CUncharacterizedHypothetical protein 0.001430.10937&radic S000000084FLO1YAR050WverifiedLectin-like protein involved in flocculation, cell wall proteinthat binds to mannose chains on the surface ofother cells, confers floc-forming ability thatis chymotrypsin sensitive and heat resistant;similar to Flo5p 0.001440.10937&radic S000000124YBL028CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis 0.001430.10937&radic S000003659YJL123CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); YJL123C is a non-essential gene 0.001410.10937&radic S000001261YHR218WUncharacterizedHelicase-like protein encoded within the telomeric Y' element 0.001380.10865&radic S000000559SPB1YCL054WverifiedAdoMet-dependent methyltransferase involved in rRNA processingand 60S ribosomal subunit maturation;methylates G2922 in the tRNA docking site ofthe large subunit rRNA and in the absence ofsnR52, U2921; suppressor of PAB1 mutants 0.001370.10865&radic S000003606YJL070CUncharacterizedPutative protein of unknown function with similarity to AMP deaminases; YJL070C is a non-essential gene 0.001370.10865&radic S000000574VBA3YCL069WverifiedPermease of basic amino acids in the vacuolar membrane 0.001380.10865&radic S000002269RRP42YDL111CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp4p, Rrp41p,Rrp43p and Dis3p 0.001340.10626&radic S000000540GRX1YCL035CverifiedHydroperoxide and superoxide-radical responsive heat-stableglutathione-dependent disulfide oxidoreductasewith active site cysteine pair; protects cellsfrom oxidative damage 0.001330.10626&radic S000005940VTC3YPL019CverifiedVacuolar membrane protein involved in vacuolar polyphosphateaccumulation; functions as a regulator ofvacuolar H+-ATPase activity and vacuolartransporter chaperones; involved innon-autophagic vacuolar fusion 0.001320.10626&radic&radic S000000077YAR029WUncharacterizedMember of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.001350.10626&radic S000000701PAU3YCR104WverifiedPart of 23-member seripauperin multigene family encoded mainlyin subtelomeric regions, active duringalcoholic fermentation, regulated byanaerobiosis, negatively regulated by oxygen,repressed by heme 0.001280.10478&radic S000004258SEC22YLR268WverifiedR-SNARE protein; assembles into SNARE complex with Bet1p, Bos1pand Sed5p; cycles between the ER and Golgicomplex; involved in anterograde and retrogradetransport between the ER and Golgi;synaptobrevin homolog 0.00130.10478 S000002653MNN10YDR245WverifiedSubunit of a Golgi mannosyltransferase complex also containingAnp1p, Mnn9p, Mnn11p, and Hoc1p that mediateselongation of the polysaccharide mannanbackbone; membrane protein of themannosyltransferase family 0.00130.10478 S000003687SNA3YJL151CverifiedIntegral membrane protein localized to vacuolar intralumenalvesicles, computational analysis of large-scaleprotein-protein interaction data suggests apossible role in either cell wall synthesis orprotein-vacuolar targeting 0.001290.10478&radic&radic S000003661GCD14YJL125CverifiedSubunit of tRNA (1-methyladenosine) methyltransferase, withGcd10p, required for the modification of theadenine at position 58 in tRNAs, especiallytRNAi-Met; first identified as a negativeregulator of GCN4 expression 0.001240.10342&radic S000003895SGM1YJR134CverifiedProtein of unknown function, required for wild-type growth rateon galactose and mannose; localizes to COPIcoated vesicles and the Golgi apparatus 0.001260.10342 S000001338SEC28YIL076WverifiedEpsilon-COP subunit of the coatomer; regulates retrogradeGolgi-to-ER protein traffic; stabilizes Cop1p,the alpha-COP and the coatomer complex;non-essential for cell growth 0.001240.10342&radic&radic S000004986COG6YNL041CverifiedComponent of the conserved oligomeric Golgi complex (Cog1pthrough Cog8p), a cytosolic tethering complexthat functions in protein trafficking tomediate fusion of transport vesicles to Golgicompartments 0.001210.10236 S000003193VRG4YGL225WverifiedGolgi GDP-mannose transporter; regulates Golgi function andglycosylation in Golgi 0.001170.10017&radic S000005457WRS1YOL097CverifiedCytoplasmic tryptophanyl-tRNA synthetase, aminoacylatestryptophanyl-tRNA 0.001170.10017&radic S000004029RIC1YLR039CverifiedProtein involved in retrograde transport to the cis-Golginetwork; forms heterodimer with Rgp1p that actsas a GTP exchange factor for Ypt6p; involved intranscription of rRNA and ribosomal proteingenes 0.001160.10017 S000000827GCD11YER025WverifiedGamma subunit of the translation initiation factor eIF2,involved in the identification of the startcodon; binds GTP when forming the ternarycomplex with GTP and tRNAi-Met 0.001120.09774&radic S000003653PHO86YJL117WverifiedEndoplasmic reticulum (ER) resident protein required for ERexit of the high-affinity phosphate transporterPho84p, specifically required for packaging ofPho84p into COPII vesicles 0.00110.09774&radic&radic S000000284SEC18YBR080CverifiedATPase required for the release of Sec17p during the 'priming'step in homotypic vacuole fusion and for ER toGolgi transport; homolog of the mammalian NSF 0.001060.09101 S000005742RUD3YOR216CverifiedGolgi matrix protein involved in the structural organization ofthe cis-Golgi; interacts genetically with COG3and USO1 0.001030.09101 S000000762ANP1YEL036CverifiedSubunit of the alpha-1,6 mannosyltransferase complex; type IImembrane protein; has a role in retention ofglycosyltransferases in the Golgi; involved inosmotic sensitivity and resistance toaminonitrophenyl propanediol 0.000980.09101&radic&radic S000002597SLY1YDR189WverifiedHydrophilic protein involved in vesicle trafficking between theER and Golgi; SM (Sec1/Munc-18) family proteinthat binds the tSNARE Sed5p and stimulates itsassembly into a trans-SNARE membrane-proteincomplex 0.001090.09101 S000002775YDR367WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.001050.09101&radic S000005231SEC21YNL287WverifiedGamma subunit of coatomer, a heptameric protein complex thattogether with Arf1p forms the COPI coat;involved in ER to Golgi transport of selectivecargo 0.000980.09101 S000005343FRE4YNR060WverifiedFerric reductase, reduces a specific subset ofsiderophore-bound iron prior to uptake bytransporters; expression induced by low ironlevels 0.000950.09101&radic S000002304COP1YDL145CverifiedAlpha subunit of COPI vesicle coatomer complex, which surroundstransport vesicles in the early secretorypathway 0.000960.09101&radic S000002646SEC26YDR238CverifiedEssential beta-coat protein of the COPI coatomer, involved inER-to-Golgi protein trafficking and maintenanceof normal ER morphology; shares 43% sequenceidentity with mammalian beta-coat protein(beta-COP) 0.000980.09101 S000001165EPT1YHR123Wverifiedsn-1,2-diacylglycerol ethanolamine- andcholinephosphotranferase; not essential forviability 0.000940.09049 S000006232YOP1YPR028WverifiedMembrane protein that interacts with Yip1p to mediate membranetraffic; overexpression results in cell deathand accumulation of internal cell membranes;regulates vesicular traffic in stressed cells 0.000920.08718&radic&radic S000003836HOC1YJR075WverifiedAlpha-1,6-mannosyltransferase involved in cell wall mannanbiosynthesis; subunit of a Golgi-localizedcomplex that also contains Anp1p, Mnn9p,Mnn11p, and Mnn10p; identified as a suppressorof a cell lysis sensitive pkc1-371 allele 0.000880.08718 S000000915YER113CUncharacterizedHypothetical protein 0.00080.08201 S000003105SEC27YGL137WverifiedEssential beta'-coat protein of the COPI coatomer, involved inER-to-Golgi and Golgi-to-ER transport; containsWD40 domains that mediate cargo selectiveinteractions; 45% sequence identity tomammalian beta'-COP 0.000810.08201 S000000959COG3YER157WverifiedEssential component of the conserved oligomeric Golgi complex(Cog1p through Cog8p), a cytosolic tetheringcomplex that functions in protein traffickingto mediate fusion of transport vesicles toGolgi compartments 0.000810.08201 S000003352COG2YGR120CverifiedEssential component of the conserved oligomeric Golgi complex(Cog1p through Cog8p), a cytosolic tetheringcomplex that functions in protein traffickingto mediate fusion of transport vesicles toGolgi compartments 0.000780.07956 S000003719MNN11YJL183WverifiedSubunit of a Golgi mannosyltransferase complex that alsocontains Anp1p, Mnn9p, Mnn10p, and Hoc1p, andmediates elongation of the polysaccharidemannan backbone; has homology to Mnn10p 0.000780.07956 S000002672AKR1YDR264CverifiedPalmitoyl transferase involved in protein palmitoylation; actsas a negative regulator of pheromone responsepathway; required for endocytosis of pheromonereceptors; involved in cell shape control;contains ankyrin repeats 0.000790.07956 S000003792GEA1YJR031CverifiedGuanine nucleotide exchange factor for ADP ribosylation factors(ARFs), involved in vesicular transport betweenthe Golgi and ER, Golgi organization, and actincytoskeleton organization; similar to but notfunctionally redundant with Gea2p 0.000760.07645 S000002911LPP1YDR503CverifiedLipid phosphate phosphatase, catalyzes Mg(2+)-independentdephosphorylation of phosphatidic acid (PA),lysophosphatidic acid, and diacylglycerolpyrophosphate; involved in control of thecellular levels of phosphatidylinositol and PA 0.000720.07403 S000004583VAN1YML115CverifiedComponent of the mannan polymerase I; forms a complex withMnn9p, which is involved in in mannansynthesis; mutants are vanadate-resistant 0.000720.07139&radic S000001546YKL063CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi 0.000710.07139&radic S000002973COG7YGL005CverifiedComponent of the conserved oligomeric Golgi complex (Cog1pthrough Cog8p), a cytosolic tethering complexthat functions in protein trafficking tomediate fusion of transport vesicles to Golgicompartments 0.000710.07139 S000004365VID22YLR373CverifiedGlycosylated integral membrane protein localized to the plasmamembrane; plays a role infructose-1,6-bisphosphatase (FBPase)degradation; involved in FBPase transport fromthe cytosol to Vid (vacuole import anddegradation) vesicles 0.000650.06676&radic&radic S000003023OLE1YGL055WverifiedFatty acid desaturase, required for monounsaturated fatty acidsynthesis and for normal distribution ofmitochondria 0.000650.06676&radic&radic S000003493APL6YGR261CverifiedBeta3-like subunit of the yeast AP-3 complex; functions intransport of alkaline phosphatase to thevacuole via the alternate pathway; exists inboth cytosolic and peripherally associatedmembrane-bound pools 0.000640.06676 S000005467YOL107WUncharacterizedHypothetical protein 0.000650.06676 S000004033TRX1YLR043CverifiedCytoplasmic thioredoxin isoenzyme of the thioredoxin systemwhich protects cells against both oxidative andreductive stress, forms LMA1 complex withPbi2p, acts as a cofactor for Tsa1p, requiredfor ER-Golgi transport and vacuole inheritance 0.000640.06593&radic S000004762NUP53YMR153WverifiedSubunit of the nuclear pore complex (NPC), interacts withkaryopherin Kap121p or with Nup170p viaoverlapping regions of Nup53p, involved inactivation of the spindle checkpoint mediatedby the Mad1p-Mad2p complex 0.000630.06427&radic&radic S000001034YHL042WUncharacterizedPutative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins 0.000630.06427&radic&radic S000004730PKR1YMR123WverifiedV-ATPase assembly factor, functions with other V-ATPaseassembly factors in the ER to efficientlyassemble the V-ATPase membrane sector(V0); overproduction confersresistance to Pichia farinosa killer toxin 0.000620.06427&radic&radic S000002884YDR476CUncharacterizedHypothetical protein 0.000620.06427&radic&radic S000004741YMR134WUncharacterizedPutative protein of unknown function that is highly conserved in ascomycetes and may be involved in mitochondrial function; localized to the endoplasmic reticulum; YMR134W is an essential gene 0.000630.06427&radic S000001289KRE27YIL027CverifiedProtein of unknown function; null mutant shows K1 killer toxinresistance 0.000610.06387&radic&radic S000004924GAS1YMR307WverifiedBeta-1.3-glucanosyltransferase, required for cell wallassembly; localizes to the cell surface via aglycosylphosphatidylinositol (GPI) anchor 0.000610.06254&radic&radic S000002429CIS1YDR022CverifiedProtein of unknown function that may be involved in microtubuleorganization; high-copy suppressor of CIK1deletion 0.000580.06068&radic&radic S000004996COG5YNL051WverifiedComponent of the conserved oligomeric Golgi complex (Cog1pthrough Cog8p), a cytosolic tethering complexthat functions in protein trafficking tomediate fusion of transport vesicles to Golgicompartments 0.000590.06068 S000004795SSO2YMR183CverifiedPlasma membrane t-SNARE involved in fusion of secretoryvesicles at the plasma membrane; syntaxinhomolog that is functionally redundant withSso1p 0.000590.06068&radic&radic S000005358COS10YNR075WverifiedProtein of unknown function, member of the DUP380 subfamily ofconserved, often subtelomerically-encodedproteins 0.000580.06068&radic&radic S000001637SRP102YKL154WverifiedSignal recognition particle (SRP) receptor beta subunit;involved in SRP-dependent protein targeting;anchors Srp101p to the ER membrane 0.000580.06068&radic&radic S000002906SEC20YDR498CverifiedMembrane glycoprotein v-SNARE involved in retrograde transportfrom the Golgi to the ER; required for N- andO-glycosylation in the Golgi but not in the ER;forms a complex with the cytosolic Tip20p 0.000590.06068&radic&radic S000001295BCY1YIL033CverifiedRegulatory subunit of the cyclic AMP-dependent protein kinase(PKA), a component of a signaling pathway thatcontrols a variety of cellular processes,including metabolism, cell cycle, stressresponse, stationary phase, and sporulation 0.000580.05933&radic S000004415ATG17YLR423CverifiedProtein that interacts with and is required for activation ofApg1p protein kinase; involved in autophagy butnot in the Cvt (cytoplasm to vacuole targeting)pathway 0.000560.05752&radic&radic S000006167RBD2YPL246CverifiedPossible rhomboid protease, has similarity to eukaryoticrhomboid proteases including Pcp1p 0.000550.05629 S000004824DML1YMR211WverifiedEssential protein involved in mtDNA inheritance, may alsofunction in the partitioning of themitochondrial organelle or in the segregationof chromosomes, exhibits regions similar tomembers of a GTPase family 0.000550.05629&radic&radic S000003728SOP4YJL192CverifiedER-membrane protein; suppressor of pma1-7, deletion of SOP4slows down the export of wild-type Pma1p andPma1-7 from the ER 0.000550.05629&radic&radic S000006429CCW14YLR390W-AverifiedCovalently linked cell wall glycoprotein, present in the innerlayer of the cell wall 0.000550.05629&radic&radic S000003888RSF2YJR127CverifiedZinc-finger protein involved in transcriptional control of bothnuclear and mitochondrial genes, many of whichspecify products required for glycerol-basedgrowth, respiration, and other functions 0.000550.05571&radic&radic S000000177YBL081WUncharacterizedHypothetical protein 0.000550.05571&radic&radic S000002976PMA1YGL008CverifiedPlasma membrane H+-ATPase, pumps protons out of the cell; majorregulator of cytoplasmic pH and plasma membranepotential; part of the P2 subgroup ofcation-transporting ATPases 0.000540.05458&radic&radic&radic S000001300NOT3YIL038CverifiedSubunit of the CCR4-NOT complex, which is a globaltranscriptional regulator with roles intranscription initiation and elongation and inmRNA degradation 0.000540.05458&radic&radic S000002679YDR271CDubiousHypothetical protein 0.000520.05253&radic&radic S000006041VPS30YPL120WverifiedProtein that forms a membrane-associated complex with Apg14pthat is essential for autophagy; involved in aretrieval step of the carboxypeptidase Yreceptor, Vps10p, to the late Golgi from theendosome; involved in vacuolar protein sorting 0.000530.05253&radic&radic&radic S000005459YOL099CDubiousHypothetical protein 0.000520.05253&radic S000002664CTA1YDR256CverifiedCatalase A, breaks down hydrogen peroxide in the peroxisomalmatrix formed by acyl-CoA oxidase (Pox1p)during fatty acid beta-oxidation 0.000520.05221&radic&radic S000003601DLS1YJL065CverifiedSubunit of ISW2/yCHRAC chromatin accessibility complex alongwith Itc1p, Isw2p, and Dpb4p; involved ininheritance of telomeric silencing 0.000520.05155&radic&radic S000004143ACS2YLR153CverifiedAcetyl-coA synthetase isoform which, along with Acs1p, is thenuclear source of acetyl-coA for histoneacetlyation; mutants affect globaltranscription; required for growth on glucose;expressed under anaerobic conditions 0.000520.05155&radic&radic S000004382ECM19YLR390WverifiedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.000520.05099&radic&radic S000005971MNN9YPL050CverifiedSubunit of Golgi mannosyltransferase complex also containingAnp1p, Mnn10p, Mnn11p, and Hoc1p that mediateselongation of the polysaccharide mannanbackbone; forms a separate complex with Van1pthat is also involved in backbone elongation 0.000510.05021&radic&radic S000001540NUP120YKL057CverifiedSubunit of the Nup84p subcomplex of the nuclear pore complex(NPC), required for even distribution of NPCsaround the nuclear envelope, involved inestablishment of a normal nucleocytoplasmicconcentration gradient of the GTPase Gsp1p 0.000510.05021&radic&radic S000000041PTA1YAL043CverifiedSubunit of holo-CPF, a multiprotein complex and functionalhomolog of mammalian CPSF, required for thecleavage and polyadenylation of mRNA and snoRNA3' ends; involved in pre-tRNA processing; bindsto the phosphorylated CTD of RNAPII 0.000510.05021&radic&radic S000002907LCD1YDR499WverifiedEssential protein required for the DNA integrity checkpointpathways; interacts physically with Mec1p;putative homolog of S. pombe Rad26 and humanATRIP 0.000510.04981&radic S000005641TRS33YOR115CverifiedOne of 10 subunits of the transport protein particle (TRAPP)complex of the cis-Golgi which mediates vesicledocking and fusion; involved in endoplasmicreticulum (ER) to Golgi membrane traffic 0.000510.04981&radic&radic S000001337RPN2YIL075CverifiedSubunit of the 26S proteasome, substrate of theN-acetyltransferase Nat1p 0.000490.0453&radic&radic S000000639YCR043CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene 0.00050.0453 S000004912PRC1YMR297WverifiedVacuolar carboxypeptidase Y (proteinase C), involved in proteindegradation in the vacuole and required forfull protein degradation during sporulation 0.000480.0453&radic&radic&radic S000000196YBL100CDubiousDubious open reading frame 0.000490.0453&radic&radic S000002431FYV1YDR024WdubiousDubious open reading frame, unlikely to encode a protein; notconserved in closely related Saccharomycesspecies; mutation decreases survival uponexposure to K1 killer toxin 0.000490.0453&radic S000005486MDH2YOL126CverifiedCytoplasmic malate dehydrogenase, one of the three isozymesthat catalyze interconversion of malate andoxaloacetate; involved in gluconeogenesisduring growth on ethanol or acetate as carbonsource; interacts with Pck1p and Fbp1p 0.00050.0453&radic S000000807YND1YER005WverifiedApyrase with wide substrate specificity, involved in preventingthe inhibition of glycosylation by hydrolyzingnucleoside tri- and diphosphates which areinhibitors of glycotransferases; partiallyredundant with Gda1p 0.00050.0453 S000000413YBR209WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR209W is not an essential gene 0.000490.0453&radic&radic S000002682YDR274CDubiousHypothetical protein 0.000490.0453&radic&radic S000000823RPN3YER021WverifiedEssential, non-ATPase regulatory subunit of the 26S proteasomelid, similar to the p58 subunit of the human26S proteasome; temperature-sensitive allelescause metaphase arrest, suggesting a role forthe proteasome in cell cycle control 0.00050.0453&radic&radic S000004650NUP116YMR047CverifiedSubunit of the nuclear pore complex (NPC) that is localized toboth sides of the pore; contains a repetitiveGLFG motif that interacts with mRNA exportfactor Mex67p and with karyopherin Kap95p;homologous to Nup100p 0.000470.04488&radic S000000742NPP2YEL016CverifiedNucleotide pyrophosphatase/phosphodiesterase family member;mediates extracellular nucleotide phosphatehydrolysis along with Npp1p and Pho5p; activityand expression enhanced during conditions ofphosphate starvation 0.000480.04488&radic&radic S000000282ECM33YBR078WverifiedGPI-anchored protein of unknown function, has a possible rolein apical bud growth; GPI-anchoring on theplasma membrane crucial to function; similar toSps2p and Pst1p 0.000460.0441&radic&radic S000005373HRD1YOL013CverifiedUbiquitin-protein ligase required for endoplasmicreticulum-associated degradation (ERAD) ofmisfolded proteins; genetically linked to theunfolded protein response (UPR); regulatedthrough association with Hrd3p; contains an H2ring finger 0.000460.04393&radic&radic S000000865THO1YER063WverifiedProtein of unknown function; overproduction suppresses thetranscriptional defect caused by an hpr1mutation 0.000460.04392&radic&radic S000005279DDI3YNL335WuncharacterizedHypothetical protein 0.000450.04386&radic&radic S000001672HYM1YKL189WverifiedComponent of the RAM signaling network that is involved inregulation of Ace2p activity and cellularmorphogenesis, interacts with Kic1p and Sog2p,localizes to sites of polarized growth duringbudding and during the mating response 0.000450.04336&radic&radic S000005093PGA2YNL149CuncharacterizedEssential protein required for maturation of Gas1p and Pho8p;involved in protein trafficking; GFP-fusionprotein localizes to the ER and YFP-fusionprotein to the nuclear envelope-ER network;null mutants have a cell separation defect 0.000450.04336&radic&radic S000000447ALG7YBR243CverifiedUDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-Pfrom UDP-GlcNac to Dol-P in the ER in the firststep of the dolichol pathway of proteinasparagine-linked glycosylation; inhibited bytunicamycin 0.000450.04336&radic&radic S000004464TRM12YML005WverifiedS-adenosylmethionine-dependent methyltransferase of the sevenbeta-strand family; required for wybutosineformation in phenylalanine-accepting tRNA 0.000450.04336&radic&radic S000005161YNL217WUncharacterizedHypothetical protein 0.000440.04293&radic&radic&radic S000004090ERG27YLR100Wverified3-keto sterol reductase, catalyzes the last of three stepsrequired to remove two C-4 methyl groups froman intermediate in ergosterol biosynthesis;mutants are sterol auxotrophs 0.000440.04274&radic&radic S000005010SUN4YNL066WverifiedCell wall protein related to glucanases, possibly involved incell wall septation; member of the SUN family 0.000420.04078&radic&radic&radic S000003464NAS6YGR232WverifiedRegulatory, non-ATPase subunit of the 26S proteasome; homologof the human oncoprotein gankyrin, whichinteracts with the retinoblastoma tumorsuppressor (Rb) and cyclin-dependent kinase 4/6 0.000420.04078&radic&radic S000000956OXA1YER154WverifiedTranslocase of the mitochondrial inner membrane, mediates theinsertion of both mitochondrial- andnuclear-encoded proteins from the matrix intothe inner membrane, interacts withmitochondrial ribosomes; null is respiratorydeficient 0.000420.04078&radic&radic S000000005ERP2YAL007CverifiedProtein that forms a heterotrimeric complex with Erp1p, Emp24p,and Erv25p; member, along with Emp24p andErv25p, of the p24 family involved in ER toGolgi transport and localized to COPII-coatedvesicles 0.000410.04078&radic&radic S000003021PRM8YGL053WverifiedPheromone-regulated protein with 2 predicted transmembranesegments and an FF sequence, a motif involvedin COPII binding; forms a complex with Prp9p inthe ER; member of DUP240 gene family 0.000420.04078&radic&radic S000001049ERG11YHR007CverifiedLanosterol 14-alpha-demethylase, catalyzes the C-14demethylation of lanosterol to form4,4''-dimethylcholesta-8,14,24-triene-3-beta-ol in theergosterol biosynthesis pathway; member of thecytochrome P450 family 0.000430.04078&radic&radic S000003514BGL2YGR282CverifiedEndo-beta-1,3-glucanase, major protein of the cell wall,involved in cell wall maintenance 0.000410.04078&radic&radic&radic S000000500PHO89YBR296CverifiedNa+/Pi cotransporter, active in early growth phase; similar tophosphate transporters of Neurospora crassa;transcription regulated by inorganic phosphateconcentrations and Pho4p 0.000380.03698 S000002774YDR366CUncharacterizedHypothetical protein 0.000360.03698&radic S000004662FET3YMR058WverifiedFerro-O2-oxidoreductase required for high-affinity iron uptakeand involved in mediating resistance to copperion toxicity, belongs to class of integralmembrane multicopper oxidases 0.000370.03698&radic&radic S000000299RXT2YBR095CverifiedSubunit of the histone deacetylase Rpd3L complex; possiblyinvolved in cell fusion and invasive growth 0.000390.03698&radic&radic S000004519SPC2YML055WverifiedSubunit of signal peptidase complex (Spc1p, Spc2p, Spc3p,Sec11p), which catalyzes cleavage of N-terminalsignal sequences of proteins targeted to thesecretory pathway; homologous to mammalianSPC25 0.000360.03698&radic&radic S000004877CUE1YMR264WverifiedEndoplasmic reticulum membrane protein that recruits theubiquitin-conjugating enzyme Ubc7p to the ERwhere it functions in protein degradation;contains a CUE domain that binds ubiquitin tofacilitate intramolecular monoubiquitination 0.000370.03698&radic&radic S000000924GLO3YER122CverifiedADP-ribosylation factor GTPase activating protein (ARF GAP),involved in ER-Golgi transport; sharesfunctional similarity with Gcs1p 0.000380.03698 S000001040COS8YHL048WverifiedNuclear membrane protein, member of the DUP380 subfamily ofconserved, often subtelomerically-encodedproteins; regulation suggests a potential rolein the unfolded protein response 0.000370.03698&radic S000005086MEP2YNL142WverifiedAmmonium permease involved in regulation of pseudohyphalgrowth; belongs to a ubiquitous family ofcytoplasmic membrane proteins that transportonly ammonium (NH4+); expression is under thenitrogen catabolite repression regulation 0.000350.03598&radic&radic S000004148ASP3-3YLR158CverifiedCell-wall L-asparaginase II, involved in asparagine catabolism;expression is induced during nitrogenstarvation; four copies of ASP3 are present inthe genome reference strain S288C 0.000350.03598&radic S000001155YHR113WVerifiedCytoplasmic aspartyl aminopeptidase; cleaves unblocked N-terminal acidic amino acid residues from peptide substrates; forms a 12 subunit homo-oligomeric complex; inhibited by EDTA and 1,10-phenanthroline; M18 metalloprotease family member 0.000360.03598&radic S000000688MSH3YCR092CverifiedMismatch repair protein, forms dimers with Msh2p that mediaterepair of insertion or deletion mutations andremoval of nonhomologous DNA ends, contains aPCNA (Pol30p) binding motif required for genomestability 0.000320.03009&radic S000000016YAL018CUncharacterizedHypothetical protein 0.000330.03009&radic S000004126TIS11YLR136CverifiedmRNA-binding protein expressed during iron starvation; binds toa sequence element in the 3'-untranslatedregions of specific mRNAs to mediate theirdegradation; involved in iron homeostasis 0.000330.03009&radic&radic S000004132PUT1YLR142WverifiedProline oxidase, nuclear-encoded mitochondrial protein involvedin utilization of proline as sole nitrogensource; PUT1 transcription is induced by Put3pin the presence of proline and the absence of apreferred nitrogen source 0.000320.03009&radic S000000772GLY1YEL046CverifiedThreonine aldolase, catalyzes the cleavage of L-allo-threonineand L-threonine to glycine; involved in glycinebiosynthesis 0.000330.03009&radic S000003704SET2YJL168CverifiedHistone methyltransferase with a role in transcriptionalelongation, methylates a lysine residue ofhistone H3; associates with the C-terminaldomain of Rpo21p; histone methylation activityis regulated by phosphorylation status ofRpo21p 0.000320.03009&radic S000003212TAD1YGL243WverifiedtRNA-specific adenosine deaminase, deaminates adenosine-37 toinosine in tRNA-Ala 0.000330.03009 S000004864HOR7YMR251W-AverifiedProtein of unknown function; overexpression suppresses Ca2+sensitivity of mutants lacking inositolphosphorylceramide mannosyltransferases Csg1pand Csh1p; transcription is induced underhyperosmotic stress and repressed by alphafactor 0.000320.03009&radic&radic&radic S000000768GDA1YEL042WverifiedGuanosine diphosphatase located in the Golgi, involved in thetransport of GDP-mannose into the Golgi lumenby converting GDP to GMP after mannose istransferred its substrate 0.000330.03009 S000005378TLG2YOL018CverifiedSyntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1pand mediates fusion of endosome-derivedvesicles with the late Golgi; binds Vps45p,which prevents Tlg2p degradation and alsofacilitates t-SNARE complex formation 0.000330.03009&radic&radic S000001795OMA1YKR087CverifiedMetalloendopeptidase of the mitochondrial inner membrane,involved in turnover of membrane-embeddedproteins; member of a family of predictedmembrane-bound metallopeptidases in prokaryotesand higher eukaryotes 0.000330.03009&radic S000002217RAD59YDL059CverifiedProtein involved in the repair of double-strand breaks in DNAduring vegetative growth via recombination andsingle-strand annealing; anneals complementarysingle-stranded DNA; homologous to Rad52p 0.000320.03009&radic S000003306SMD1YGR074WverifiedCore Sm protein Sm D1; part of heteroheptameric complex (withSmb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D1 0.000350.03009&radic S000006157YPL236CUncharacterizedHypothetical protein 0.000340.03009&radic S000005297YNR014WUncharacterizedHypothetical protein 0.000340.03009&radic S000004291EXG1YLR300WverifiedMajor exo-1,3-beta-glucanase of the cell wall, involved in cellwall beta-glucan assembly; exists as threedifferentially glycosylated isoenzymes 0.000320.03009&radic&radic&radic S000004367STP3YLR375WuncharacterizedZinc-finger protein of unknown function, possibly involved inpre-tRNA splicing and in uptake ofbranched-chain amino acids 0.000340.03009&radic&radic S000003455HSV2YGR223CverifiedPhosphatidylinositol 3,5-bisphosphate-binding protein,predicted to fold as a seven-bladedbeta-propeller; displays punctate cytoplasmiclocalization 0.000320.03009&radic S000005296PHO91YNR013CverifiedLow-affinity phosphate transporter; deletion of pho84, pho87,pho89, pho90, and pho91 causes syntheticlethality; transcription independent of Pi andPho4p activity; overexpression results invigorous growth 0.000330.03009&radic S000006396AQY1YPR192WverifiedSpore-specific water channel that mediates the transport ofwater across cell membranes, developmentallycontrolled; may play a role in sporematuration, probably by allowing water outflow,may be involved in freeze tolerance 0.000320.03009&radic&radic S000005542ERP4YOR016CverifiedProtein with similarity to Emp24p and Erv25p, member of the p24family involved in ER to Golgi transport 0.000320.03009&radic&radic S000004983GPI15YNL038WverifiedProtein involved in the synthesis of N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI), the firstintermediate in the synthesis ofglycosylphosphatidylinositol (GPI) anchors;homologous to the human PIG-H protein 0.000320.03009 S000001361SGA1YIL099WverifiedIntracellular sporulation-specific glucoamylase involved inglycogen degradation; induced during starvationof a/a diploids late in sporulation, butdispensable for sporulation 0.000330.03009&radic&radic S000003615PRY1YJL079CverifiedProtein of unknown function, has similarity to Pry2p and Pry3pand to the plant PR-1 class of pathogen relatedproteins 0.000350.03009&radic&radic&radic S000004479PSP2YML017WverifiedAsn rich cytoplasmic protein that contains RGG motifs;high-copy suppressor of group IIintron-splicing defects of a mutation in MRS2and of a conditional mutation in POL1 (DNApolymerase alpha); possible role inmitochondrial mRNA splicing 0.00030.02624&radic S000004016SED5YLR026Cverifiedcis-Golgi t-SNARE syntaxin required for vesicular transportbetween the ER and the Golgi complex, binds atleast 9 SNARE proteins 0.000310.02624&radic&radic S000003529QCR10YHR001W-AverifiedSubunit of the ubiqunol-cytochrome c oxidoreductase complex,involved in aerobic respiration 0.000310.02624&radic S000000487SSH1YBR283CverifiedSubunit of the Ssh1 translocon complex; Sec61p homolog involvedin co-translational pathway of proteintranslocation; not essential 0.00030.02624&radic&radic S000005448MPD2YOL088CverifiedMember of the protein disulfide isomerase (PDI) family,exhibits chaperone activity; overexpressionsuppresses the lethality of a pdi1 deletion butdoes not complement all Pdi1p functions;undergoes oxidation by Ero1p 0.000310.02624&radic&radic&radic S000003881YJR120WVerifiedProtein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p 0.000310.02624&radic S000005591CYT1YOR065WverifiedCytochrome c1, component of the mitochondrial respiratorychain; expression is regulated by theheme-activated, glucose-repressedHap2p/3p/4p/5p CCAAT-binding complex 0.000310.02624&radic S000003812OSM1YJR051WverifiedFumarate reductase, catalyzes the reduction of fumarate tosuccinate, required for the reoxidation ofintracellular NADH under anaerobic conditions;mutations cause osmotic sensitivity 0.00030.02624&radic&radic S000005008YDJ1YNL064CverifiedProtein chaperone involved in regulation of the HSP90 and HSP70functions; involved in protein translocationacross membranes; member of the DnaJ family 0.00030.02624&radic S000004146YLR156WUncharacterizedYLR156W, YLR159W, and YLR161W are three identical open reading frames encoded near the ribosomal DNA region of chromosome 12. 0.000310.02624&radic S000001861RIM15YFL033CverifiedGlucose-repressible protein kinase involved in signaltransduction during cell proliferation inresponse to nutrients, specifically theestablishment of stationary phase; originallyidentified as a regulator of IME2 0.000310.02624&radic S000001876LPD1YFL018CverifiedDihydrolipoamide dehydrogenase, the lipoamide dehydrogenasecomponent (E3) of the pyruvate dehydrogenaseand 2-oxoglutarate dehydrogenase multi-enzymecomplexes 0.00030.02624&radic S000003175SPT16YGL207WverifiedSubunit of the heterodimeric FACT complex (Spt16p-Pob3p),facilitates RNA Polymerase II transcriptionelongation through nucleosomes by destabilizingand then reassembling nucleosome structure 0.000310.02624&radic S000005939CTF19YPL018WverifiedOuter kinetochore protein, required for accurate mitoticchromosome segregation; component of thekinetochore sub-complex COMA (Ctf19p, Okp1p,Mcm21p, Ame1p) that functions as a platform forkinetochore assembly 0.00030.02624&radic S000005460PKH2YOL100WverifiedSerine/threonine protein kinase involved insphingolipid-mediated signaling pathway thatcontrols endocytosis; activates Ypk1p andYkr2p, components of signaling cascade requiredfor maintenance of cell wall integrity;redundant with Pkh1p 0.00030.02624&radic S000004925PSE1YMR308CverifiedKaryopherin/importin that interacts with the nuclear porecomplex; acts as the nuclear import receptorfor specific proteins, including Pdr1p, Yap1p,Ste12p, and Aft1p 0.00030.02624&radic S000001499ATP7YKL016CverifiedSubunit d of the stator stalk of mitochondrial F1F0 ATPsynthase, which is a large, evolutionarilyconserved enzyme complex required for ATPsynthesis 0.00030.02495&radic S000002475DOS2YDR068WverifiedProtein of unknown function, green fluorescent protein(GFP)-fusion protein localizes to the cytoplasm 0.00030.02495 S000004480YML018CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; YML018C is not an essential gene 0.000290.02213&radic S000001084NCP1YHR042WverifiedNADP-cytochrome P450 reductase; involved in ergosterolbiosynthesis; associated and coordinatelyregulated with Erg11p 0.000290.02213&radic&radic S000003645UTP10YJL109CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.00030.02213&radic S000003311YGR079WUncharacterizedPutative protein of unknown function; YGR079W is not an essential gene 0.000290.02213&radic S000000902UBC6YER100WverifiedUbiquitin-conjugating enzyme involved in ER-associated proteindegradation; located at the cytosolic side ofthe ER membrane; tail region contains atransmembrane segment at the C-terminus;substrate of the ubiquitin-proteasome pathway 0.000290.02213&radic S000003386GTO1YGR154CuncharacterizedOmega-class glutathione transferase; induced under oxidativestress; putative peroxisomal localization 0.000290.02213&radic S000002567SSY1YDR160WverifiedComponent of the SPS plasma membrane amino acid sensor system(Ssy1p-Ptr3p-Ssy5p), which senses externalamino acid concentration and transmitsintracellular signals that result in regulationof expression of amino acid permease genes 0.000290.02213&radic S000004021YLR031WUncharacterizedHypothetical protein 0.000290.02213&radic&radic&radic S000003024SDS23YGL056CverifiedOne of two S. cerevisiae homologs (Sds23p and Sds24p) of theSchizosaccharomyces pombe Sds23 protein, whichgenetic studies have implicated inAPC/cyclosome regulation 0.000290.02213&radic S000001765RPS21AYKR057WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps21Bp and has similarity to ratS21 ribosomal protein 0.000290.02213&radic S000005334BRE5YNR051CverifiedUbiquitin protease cofactor, forms deubiquitination complexwith Ubp3p that coregulates anterograde andretrograde transport between the endoplasmicreticulum and Golgi compartments; null issensitive to brefeldin A 0.000290.02213&radic S000000349ADH5YBR145WverifiedAlcohol dehydrogenase isoenzyme V; involved in ethanolproduction 0.000290.02211&radic S000002599HST4YDR191WverifiedMember of the Sir2 family of NAD(+)-dependent proteindeacetylases; involved along with Hst3p insilencing at telomeres, cell cycle progression,radiation resistance, genomic stability andshort-chain fatty acid metabolism 0.000290.02211&radic S000003899IML1YJR138WverifiedProtein of unknown function, green fluorescent protein(GFP)-fusion protein localizes to the vacuolarmembrane 0.000290.02211&radic S000000426PCS60YBR222CverifiedPeroxisomal AMP-binding protein, localizes to both theperoxisomal peripheral membrane and matrix,expression is highly inducible by oleic acid,similar to E. coli long chain acyl-CoAsynthetase 0.000280.0207&radic S000005119NOP13YNL175CverifiedProtein of unknown function, localizes to the nucleolus andnucleoplasm; contains an RNA recognition motif(RRM) and has similarity to Nop12p, which isrequired for processing of pre-18S rRNA 0.000280.0207&radic S000000845SAH1YER043CverifiedS-adenosyl-L-homocysteine hydrolase, catabolizesS-adenosyl-L-homocysteine which is formed afterdonation of the activated methyl group ofS-adenosyl-L-methionine (AdoMet) to an acceptor 0.000280.0207&radic S000004775PAH1YMR165CverifiedMg2+-dependent phosphatidate (PA) phosphatase,catalyzes the dephosphorylation of PA to yielddiacylglycerol and Pi, responsiblefor de novo lipid synthesis; homologous tomammalian lipin 1 0.000290.0207 S000004675TVP18YMR071CverifiedIntegral membrane protein localized to late Golgi vesiclesalong with the v-SNARE Tlg2p 0.000280.0207&radic&radic S000001388STH1YIL126WverifiedATPase component of the ATP-dependent RSC chromatin remodelingcomplex required for kinetochore function inchromosome segregation; required for expressionof early meiotic genes; essentialhelicase-related protein homologous to Snf2p 0.000280.0207&radic S000001490CAP1YKL007WverifiedAlpha subunit of the capping protein (CP) heterodimer (Cap1pand Cap2p) which binds to the barbed ends ofactin filaments preventing furtherpolymerization; localized predominantly tocortical actin patches 0.000280.02011&radic S000000296PHO3YBR092CverifiedConstitutively expressed acid phosphatase similar to Pho5p;brought to the cell surface by transportvesicles; hydrolyzes thiamin phosphates in theperiplasmic space, increasing cellular thiaminuptake; expression is repressed by thiamin 0.000280.0195&radic&radic&radic S000003900HOM6YJR139CverifiedHomoserine dehydrogenase (L-homoserine:NADP oxidoreductase),dimeric enzyme that catalyzes the third step inthe common pathway for methionine and threoninebiosynthesis; enzyme has nucleotide-binding,dimerization and catalytic regions 0.000280.0195&radic S000004867YMR254CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data 0.000280.0195&radic S000002548DOP1YDR141CverifiedProtein of unknown function, essential for viability, involvedin establishing cellular polarity andmorphogenesis; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.000280.0195&radic S000003978YLL055WUncharacterizedPutative protein of unknown function with similarity to transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLL055W is not an essential gene 0.000280.01888&radic S000000015PSK1YAL017WverifiedOne of two (see also PSK2) PAS domain containing S/T proteinkinases; coordinately regulates proteinsynthesis and carbohydrate metabolism andstorage in response to a unknown metabolitethat reflects nutritional status 0.000280.01888&radic S000005871TYE7YOR344CverifiedSerine-rich protein that contains a basic-helix-loop-helix(bHLH) DNA binding motif; binds E-boxes ofglycolytic genes and contributes to theiractivation; may function as a transcriptionalactivator in Ty1-mediated gene expression 0.000280.01888&radic S000005624NUP1YOR098CverifiedNuclear pore complex (NPC) subunit, involved in proteinimport/export and in export of RNAs, possiblekaryopherin release factor that acceleratesrelease of karyopherin-cargo complexes aftertransport across NPC; potential Cdc28psubstrate 0.000270.0182&radic S000001179ARO9YHR137WverifiedAromatic aminotransferase, catalyzes the first step oftryptophan, phenylalanine, and tyrosinecatabolism 0.000270.0182&radic S000003856SFC1YJR095WverifiedMitochondrial succinate-fumarate transporter, transportssuccinate into and fumarate out of themitochondrion; required for ethanol and acetateutilization 0.000270.0182&radic&radic S000002164PTC1YDL006WverifiedType 2C protein phosphatase (PP2C); inactivates the osmosensingMAPK cascade by dephosphorylating Hog1p;mutation delays mitochondrial inheritance;deletion reveals defects in precursor tRNAsplicing, sporulation and cell separation 0.000270.0182&radic S000002796RVS167YDR388WverifiedActin-associated protein, subunit of a complex(Rvs161p-Rvs167p) involved in regulation ofactin cytoskeleton, endocytosis, and viabilityfollowing starvation or osmotic stress; homologof mammalian amphiphysin 0.000270.0182 S000001350AVT7YIL088CverifiedPutative transporter, member of a family of seven S. cerevisiaegenes (AVT1-7) related to vesicularGABA-glycine transporters 0.000270.0182&radic S000001102VMA22YHR060WverifiedIntegral membrane protein that is required for vacuolarH+-ATPase (V-ATPase) function, although not anactual component of the V-ATPase complex;functions in the assembly of the V-ATPase;localized to the yeast endoplasmic reticulum(ER) 0.000270.0182&radic&radic S000002776YPR1YDR368Wverified2-methylbutyraldehyde reductase, may be involved in isoleucinecatabolism 0.000270.0182&radic S000000751YEL025CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 0.000270.0182&radic S000000024DRS2YAL026CverifiedAminophospholipid translocase (flippase) that maintainsmembrane lipid asymmetry in post-Golgisecretory vessicles; localizes to thetrans-Golgi network; contributes toclathrin-coated vesicle formation andendocytosis; type 4 P-type ATPase 0.000270.01673&radic S000003880JHD2YJR119CuncharacterizedPutative protein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to the cytoplasmand nucleus 0.000270.01673&radic S000002916GNP1YDR508CverifiedHigh-affinity glutamine permease, also transports Leu, Ser,Thr, Cys, Met and Asn; expression is fullydependent on Grr1p and modulated by theSsy1p-Ptr3p-Ssy5p (SPS) sensor of extracellularamino acids 0.000270.01673&radic&radic S000005165POP1YNL221CverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends; binds to the RPR1 RNAsubunit in Rnase P 0.000270.01673&radic S000000926DSE1YER124CverifiedDaughter cell-specific protein, may participate in pathwaysregulating cell wall metabolism; deletionaffects cell separation after division andsensitivity to drugs targeted against the cellwall 0.000270.01673&radic S000002209LHP1YDL051WverifiedRNA binding protein required for maturation of tRNA and snRNAprecursors; acts as a molecular chaperone forRNAs transcribed by polymerase III; homologousto human La (SS-B) autoantigen 0.000270.01673&radic S000000028SNC1YAL030WverifiedVesicle membrane receptor protein (v-SNARE) involved in thefusion between Golgi-derived secretory vesicleswith the plasma membrane; proposed to beinvolved in endocytosis; member of thesynaptobrevin/VAMP family of R-type v-SNAREproteins 0.000270.01673&radic&radic S000000883SER3YER081Wverified3-phosphoglycerate dehydrogenase, catalyzes the first step inserine and glycine biosynthesis; isozyme ofSer33p 0.000270.01673 S000003702QCR8YJL166WverifiedSubunit 8 of ubiquinol cytochrome-c reductase complex, which isa component of the mitochondrial inner membraneelectron transport chain; oriented facing theintermembrane space; expression is regulated byAbf1p and Cpf1p 0.000270.01673&radic S000004139YLR149CUncharacterizedPutative protein of unknown function; YLR149C is not an essential gene 0.000260.01656&radic S000006307PRE2YPR103Wverified20S proteasome beta-type subunit, responsible for thechymotryptic activity of the proteasome 0.000260.01656&radic S000003432ELP2YGR200CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;target of Kluyveromyces lactis zymocin 0.000260.01594&radic S000005989YPL068CUncharacterizedHypothetical protein 0.000260.01594&radic S000005997GPI2YPL076WverifiedProtein involved in the synthesis of N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI), the firstintermediate in the synthesis ofglycosylphosphatidylinositol (GPI) anchors;homologous to the human PIG-C protein 0.000260.01594 S000002705SUR2YDR297WverifiedSphinganine C4-hydroxylase, catalyses the conversion ofsphinganine to phytosphingosine in sphingolipidbiosyntheis 0.000260.01594&radic S000001456MET28YIR017CverifiedTranscriptional activator in the Cbf1p-Met4p-Met28p complex,participates in the regulation of sulfurmetabolism 0.000260.01594&radic S000002462PST1YDR055WverifiedCell wall protein that contains a putative GPI-attachment site;secreted by regenerating protoplasts;up-regulated by activation of the cellintegrity pathway, as mediated by Rlm1p;upregulated by cell wall damage via disruptionof FKS1 0.000260.01594&radic S000000294YBR090CUncharacterizedHypothetical protein 0.000260.01594&radic&radic S000004164IDP2YLR174WverifiedCytosolic NADP-specific isocitrate dehydrogenase, catalyzesoxidation of isocitrate to alpha-ketoglutarate;levels are elevated during growth onnon-fermentable carbon sources and reducedduring growth on glucose 0.000260.01594&radic S000002814PDR15YDR406WverifiedATP binding cassette (ABC) transporter of the plasma membrane;general stress response factor implicated incellular detoxification; target of Pdr1p, Pdr3pand Pdr8p transcription regulators; promotercontains a PDR responsive element 0.000260.01594&radic S000005221MET2YNL277WverifiedL-homoserine-O-acetyltransferase, catalyzes the conversion ofhomoserine to O-acetyl homoserine which is thefirst step of the methionine biosyntheticpathway 0.000260.01594&radic S000000240CSG2YBR036CverifiedEndoplasmic reticulum membrane protein, required formannosylation of inositolphosphorylceramide andfor growth at high calcium concentrations 0.000260.01532&radic&radic&radic S000000896PUP3YER094CverifiedBeta subunit of the 20S proteasome involved inubiquitin-dependent catabolism; human homologis subunit C10 0.000260.01532&radic S000000901PRS2YER099Cverified5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involvedin nucleotide, histidine, and tryptophanbiosynthesis; one of a five related enzymes,which are active as heteromultimeric complexes 0.000260.01532&radic S000004589NDI1YML120CverifiedNADH:ubiquinone oxidoreductase, transfers electrons from NADHto ubiquinone in the respiratory chain but doesnot pump protons, in contrast to the highereukaryotic multisubunit respiratory complex I;homolog of human AMID 0.000260.01532&radic S000001926MET10YFR030WverifiedSubunit alpha of assimilatory sulfite reductase, which isresponsible for the conversion of sulfite intosulfide 0.000260.01532&radic S000006175HFI1YPL254WverifiedAdaptor protein required for structural integrity of the SAGAcomplex, a histoneacetyltransferase-coactivator complex that isinvolved in global regulation of geneexpression through acetylation andtranscription functions 0.000260.01532&radic S000005590YNG1YOR064CverifiedSubunit of the NuA3 histone acetyltransferase complex thatacetylates histone H3; has similarity to thehuman tumor suppressor ING1 0.000260.01474&radic S000003161YGL193CUncharacterizedHaploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold 0.000250.01474&radic S000003292ERG25YGR060WverifiedC-4 methyl sterol oxidase, catalyzes the first of three stepsrequired to remove two C-4 methyl groups froman intermediate in ergosterol biosynthesis;mutants accumulate the sterol intermediate4,4-dimethylzymosterol 0.000260.01474&radic&radic S000000227CHS3YBR023CverifiedChitin synthase III, catalyzes the transfer ofN-acetylglucosamine (GlcNAc) to chitin;required for synthesis of the majority of cellwall chitin, the chitin ring during budemergence, and spore wall chitosan 0.000250.01474 S000004590GTR1YML121WverifiedCytoplasmic GTP binding protein and negative regulator, withhomolog Gtr2p, of the Ran/Tc4 GTPase cycle;component of GSE complex, which is required forsorting of Gap1p; involved in phosphatetransport; has homology to human RagA and RagB 0.000260.01474&radic S000002278YFH1YDL120WverifiedFrataxin, regulates mitochondrial iron accumulation; interactswith Isu1p which promotes Fe-S clusterassembly; interacts with electron transportchain components and may influence respiration;human homolog involved in Friedrich's ataxia 0.000250.01474&radic S000000802YEL076CUncharacterizedHypothetical protein 0.000250.01474&radic&radic S000002675CIA1YDR267CverifiedEssential protein involved in assembly of cytosolic and nucleariron-sulfur proteins 0.000260.01474&radic S000006276NOT5YPR072WverifiedSubunit of the CCR4-NOT complex, which is a globaltranscriptional regulator with roles intranscription initiation and elongation and inmRNA degradation 0.000250.01474&radic S000002230YET3YDL072CverifiedProtein of unknown function; YET3 null mutant decreases thelevel of secreted invertase; homolog of humanBAP31 protein 0.000250.01474&radic&radic S000006295YPR091CUncharacterizedHypothetical protein 0.000260.01474&radic&radic S000003631BCK1YJL095WverifiedMitogen-activated protein (MAP) kinase kinase kinase acting inthe protein kinase C signaling pathway, whichcontrols cell integrity; upon activation byPkc1p phosphorylates downstream kinases Mkk1pand Mkk2p 0.000250.01454 S000005688YRR1YOR162CverifiedZn2-Cys6 zinc-finger transcription factor that activates genesinvolved in multidrug resistance; paralog ofYrm1p, acting on an overlapping set of targetgenes 0.000250.01454&radic S000000750RIP1YEL024WverifiedUbiquinol-cytochrome-c reductase, a Rieske iron-sulfur proteinof the mitochondrial cytochrome bc1 complex;transfers electrons from ubiquinol tocytochrome c1 during respiration 0.000250.01454&radic S000006092OYE3YPL171CverifiedWidely conserved NADPH oxidoreductase containing flavinmononucleotide (FMN), homologous to Oye2p withslight differences in ligand binding andcatalytic properties; may be involved in sterolmetabolism 0.000250.01454&radic S000006332ANT1YPR128CverifiedPeroxisomal adenine nucleotide transporter; involved inbeta-oxidation of medium-chain fatty acid;required for peroxisome proliferation 0.000250.01454 S000002701SSD1YDR293CverifiedProtein with a role in maintenance of cellular integrity,interacts with components of the TOR pathway;ssd1 mutant of a clinical S. cerevisiae straindisplays elevated virulence 0.000250.01454 S000004292YLR301WUncharacterizedProtein of unknown function that interacts with Sec72p 0.000250.01454&radic S000002598RVB1YDR190CverifiedEssential protein involved in transcription regulation;component of chromatin remodeling complexes;required for assembly and function of the INO80complex; member of the RUVB-like protein family 0.000250.01438&radic S000004808ICY1YMR195WuncharacterizedProtein of unknown function, required for viability in richmedia of cells lacking mitochondrial DNA 0.000250.01438&radic S000006404ARR2YPR200CverifiedArsenate reductase required for arsenate resistance; convertsarsenate to arsenite which can then be exportedfrom cells by Arr3p 0.000250.01438&radic S000001781YKR073CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data 0.000250.01418&radic S000004270YLR280CDubiousHypothetical protein 0.000250.01418&radic S000001498PUT3YKL015WverifiedTranscriptional activator of proline utilization genes,constitutively binds PUT1 and PUT2 promotersequences and undergoes a conformational changeto form the active state; has a Zn(2)-Cys(6)binuclear cluster domain 0.000250.01418&radic S000002804YDR396WDubiousHypothetical protein; open reading frame extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex 0.000250.01418&radic S000003465PHO81YGR233CverifiedCyclin-dependent kinase (CDK) inhibitor, regulatesPho80p-Pho85p and Pcl7p-Pho85p cyclin-CDKcomplexes in response to phosphate levels;required for derepression of PHO5;transcriptionally regulated by Pho4p and Pho2p 0.000250.01418&radic S000001862YFL032WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene 0.000250.01418&radic S000004591YML122CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data 0.000250.01418&radic S000003907YJR146WDubiousHypothetical protein 0.000250.01418&radic S000003655YJL119CDubiousHypothetical protein 0.000250.01418&radic S000002938APA2YDR530CverifiedDiadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4Aphosphorylase), involved in catabolism ofbis(5'-nucleosidyl) tetraphosphates; hassimilarity to Apa1p 0.000250.01418&radic S000000428YBR224WDubiousHypothetical protein 0.000250.01418&radic S000005826YOR300WDubiousDubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7 0.000250.01418&radic S000003462BNS1YGR230WverifiedProtein with some similarity to Spo12p; overexpression bypassesneed for Spo12p, but not required for meiosis 0.000250.01418&radic S000003908HMS2YJR147WverifiedProtein with similarity to heat shock transcription factors;overexpression suppresses the pseudohyphalfilamentation defect of a diploid mep1 mep2homozygous null mutant 0.000250.01418&radic S000000255YBR051WDubiousHypothetical protein 0.000250.01418&radic S000003747YJL211CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2 0.000250.01418&radic S000001294YIL032CDubiousHypothetical protein 0.000250.01418&radic S000000348YBR144CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene 0.000250.01418&radic S000005227WSC2YNL283CverifiedPartially redundant sensor-transducer of the stress-activatedPKC1-MPK1 signaling pathway involved inmaintenance of cell wall integrity and recoveryfrom heat shock; secretory pathway Wsc2p isrequired for the arrest of secretion response 0.000250.01418&radic S000003686YJL150WDubiousHypothetical protein 0.000250.01418&radic S000000771YEL045CDubiousDubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress 0.000250.01418&radic S000004364SUR4YLR372WverifiedElongase, involved in fatty acid and sphingolipid biosynthesis;synthesizes very long chain 20-26-carbon fattyacids from C18-CoA primers; involved inregulation of sphingolipid biosynthesis 0.000250.01409 S000000630FEN1YCR034WverifiedFatty acid elongase, involved in sphingolipid biosynthesis;acts on fatty acids of up to 24 carbons inlength; mutations have regulatory effects on1,3-beta-glucan synthase, vacuolar ATPase, andthe secretory pathway 0.000250.01409&radic S000002958FCY22YER060W-AverifiedPutative purine-cytosine permease, very similar to Fcy2p butcannot substitute for its function 0.000250.01409&radic S000004830GUA1YMR217WverifiedGMP synthase, an enzyme that catalyzes the second step in thebiosynthesis of GMP from inosine 5'-phosphate(IMP); transcription is not subject toregulation by guanine but is negativelyregulated by nutrient starvation 0.000250.01373&radic S000004294MET17YLR303WverifiedO-acetyl homoserine-O-acetyl serine sulfhydrylase, required forsulfur amino acid synthesis 0.000250.01373&radic S000002350RPL35AYDL191WverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl35Bp and has similarity to ratL35 ribosomal protein 0.000240.01373&radic&radic S000000914LSM4YER112WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.000240.01373&radic S000001154YHR112CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.000240.01358&radic S000004401UTP21YLR409CuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.000240.01358&radic S000000453ARO4YBR249Cverified3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase,catalyzes the first step in aromatic amino acidbiosynthesis and is feedback-inhibited bytyrosine or high concentrations ofphenylalanine or tryptophan 0.000240.01282&radic S000001078BRL1YHR036WverifiedEssential nuclear envelope integral membrane protein identifiedas a suppressor of a cold-sensitive mutant ofCRM1, a karyopherin; homologous to andinteracts with Brr6p, which is a nuclearenvelope protein involved in nuclear export 0.000240.01282&radic&radic S000000178ALG3YBL082CverifiedDolichol-P-Man dependent alpha(1-3) mannosyltransferase,involved in the synthesis of dolichol-linkedoligosaccharide donor for N-linkedglycosylation of proteins 0.000240.01282&radic S000002157NHP6BYBR089C-AverifiedHigh-mobility group non-histone chromatin protein, functionallyredundant with Nhp6Ap; homologous to mammalianhigh mobility group proteins 1 and 2; acts torecruit transcription factor Rcs1p to certainpromoters 0.000240.01282&radic&radic S000003281SCM4YGR049WverifiedPotential regulatory effector of CDC4 function, suppresses atemperature-sensitive allele of CDC4,tripartite protein structure in which a chargedregion separates two uncharged domains, notessential for mitosis or meiosis 0.000240.01282&radic S000001178SPL2YHR136CverifiedProtein with similarity to cyclin-dependent kinase inhibitors,overproduction suppresses a plc1 null mutation;green fluorescent protein (GFP)-fusion proteinlocalizes to the cytoplasm in a punctatepattern 0.000240.01282&radic S000002676MSW1YDR268WverifiedMitochondrial tryptophanyl-tRNA synthetase 0.000240.01282&radic S000005048LEU4YNL104CverifiedAlpha-isopropylmalate synthase (2-isopropylmalate synthase);the main isozyme responsible for the first stepin the leucine biosynthesis pathway 0.000240.01282&radic S000001929QCR6YFR033CverifiedSubunit 6 of the ubiquinol cytochrome-c reductase complex,which is a component of the mitochondrial innermembrane electron transport chain; highlyacidic protein; required for maturation ofcytochrome c1 0.000240.01282&radic S000001245YHR202WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization 0.000240.01282&radic&radic&radic S000001182YHR140WUncharacterizedPutative integral membrane protein of unknown function 0.000240.01273&radic&radic S000000050ACS1YAL054CverifiedAcetyl-coA synthetase isoform which, along with Acs2p, is thenuclear source of acetyl-coA for histoneacetlyation; expressed during growth onnonfermentable carbon sources and under aerobicconditions 0.000240.01273&radic S000005492GAS4YOL132WverifiedPutative 1,3-beta-glucanosyltransferase, has similarity toGas1p; localizes to the cell wall 0.000240.01273 S000005344YNR061CUncharacterizedHypothetical protein 0.000240.01273&radic&radic&radic S000001571YKL088WUncharacterizedPredicted phosphopantothenoylcysteine decarboxylase, may be involved in coenzyme A biosynthesis; interacts with Sis2p and Vhs3p 0.000230.01266&radic&radic S000004273YLR283WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene 0.000230.01266&radic S000004887RCE1YMR274CverifiedType II CAAX prenyl protease involved in the proteolysis andmaturation of Ras and the a-factor matingpheromone 0.000230.01266&radic&radic S000002231YDL073WUncharacterizedPutative protein of unknown function; YDL073W is not an essential gene 0.000230.01233&radic S000003407ERG1YGR175CverifiedSqualene epoxidase, catalyzes the epoxidation of squalene to2,3-oxidosqualene; plays an essential role inthe ergosterol-biosynthesis pathway and is thespecific target of the antifungal drugterbinafine 0.000230.01233&radic&radic S000003387CYS4YGR155WverifiedCystathionine beta-synthase, catalyzes the synthesis ofcystathionine from serine and homocysteine, thefirst committed step in cysteine biosynthesis 0.000230.01233&radic S000005316ABZ1YNR033WverifiedPara-aminobenzoate (PABA) synthase, has similarity toEscherichia coli PABA synthase components PabAand PabB 0.000230.01233&radic S000003878STE24YJR117WverifiedHighly conserved zinc metalloprotease that functions in twosteps of a-factor maturation, C-terminal CAAXproteolysis and the first step of N-terminalproteolytic processing; contains multipletransmembrane spans 0.000230.01233 S000000286UBC4YBR082CverifiedUbiquitin-conjugating enzyme that mediates degradation ofshort-lived and abnormal proteins; interactswith E3-CaM in ubiquitinating calmodulin;interacts with many SCF ubiquitin proteinligases; component of the cellular stressresponse 0.000230.01233&radic&radic&radic S000003636LSB6YJL100WverifiedPhosphatidylinositol 4-kinase that binds Las17p, which is ahomolog of human Wiskott-Aldrich Syndromeprotein involved in actin patch assembly andactin polymerization 0.000230.01233&radic S000003348SPT6YGR116WverifiedEssential protein that interacts with histones and is involvedin nucleosome disassembly and reassembly duringtranscription elongation 0.000230.01233&radic S000000602RVS161YCR009CverifiedAmphiphysin-like lipid raft protein; subunit of a complex(Rvs161p-Rvs167p) that regulates polarizationof the actin cytoskeleton, endocytosis, cellpolarity, cell fusion and viability followingstarvation or osmotic stress 0.000230.01233 S000004276CTS1YLR286CverifiedEndochitinase, required for cell separation after mitosis;transcriptional activation during late G andearly M cell cycle phases is mediated bytranscription factor Ace2p 0.000230.01233&radic&radic&radic S000003189NIF3YGL221CverifiedProtein of unknown function, similar to Listeria monocytogenesmajor sigma factor (rpoD gene product); theauthentic, non-tagged protein is detected inhighly purified mitochondria in high-throughputstudies 0.000230.01233&radic S000006156RVB2YPL235WverifiedEssential protein involved in transcription regulation;component of chromatin remodeling complexes;required for assembly and function of the INO80complex; member of the RUVB-like protein family 0.000230.01189&radic S000005352BSC5YNR069CverifiedProtein of unknown function, ORF exhibits genomic organizationcompatible with a translationalreadthrough-dependent mode of expression 0.000230.01189&radic&radic S000000363IFA38YBR159WverifiedMicrosomal beta-keto-reductase; contains oleate responseelement (ORE) sequence in the promoter region;mutants exhibit reduced VLCFA synthesis,accumulate high levels of dihydrosphingosine,phytosphingosine and medium-chain ceramides. 0.000230.01189 S000003121PEX14YGL153WverifiedPeroxisomal membrane protein that is a central component of theperoxisomal protein import machinery, interactswith PTS1 (Pex5p) and PTS2 (Pex7p) peroxisomalmatrix protein signal recognition factors andmembrane receptor Pex13p 0.000230.01189&radic&radic S000005164ADE12YNL220WverifiedAdenylosuccinate synthase, catalyzes the first committed stepin the 'de novo' biosynthesis of adenosine 0.000230.01189&radic S000000893MET6YER091CverifiedCobalamin-independent methionine synthase, involved in aminoacid biosynthesis; requires a minimum of twoglutamates on the methyltetrahydrofolatesubstrate, similar to bacterial metE homologs 0.000230.01189&radic S000001870EPL1YFL024CverifiedComponent of NuA4, which is an essential histone H4/H2Aacetyltransferase complex; homologous toDrosophila Enhancer of Polycomb 0.000230.01189&radic S000001141TRA1YHR099WverifiedSubunit of SAGA and NuA4 histone acetyltransferase complexes;interacts with acidic activators (e.g., Gal4p)which leads to transcription activation;similar to human TRRAP, which is a cofactor forc-Myc mediated oncogenic transformation 0.000230.01189&radic S000003456AZR1YGR224WverifiedPlasma membrane transporter of the major facilitatorsuperfamily, involved in resistance to azoledrugs such as ketoconazole and fluconazole 0.000230.01189&radic S000001385SIM1YIL123WverifiedProtein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that mayparticipate in DNA replication, promotercontains SCB regulation box at -300 bpindicating that expression may be cellcycle-regulated 0.000230.01183&radic&radic&radic S000005829CPA1YOR303WverifiedSmall subunit of carbamoyl phosphate synthetase, whichcatalyzes a step in the synthesis ofcitrulline, an arginine precursor;translationally regulated by an attenuatorpeptide encoded by YOR302W within the CPA1 mRNA5'-leader 0.000230.01183&radic S000000429YBR225WUncharacterizedHypothetical protein 0.000230.01183&radic S000005117MDG1YNL173CverifiedPlasma membrane protein involved in G-protein mediatedpheromone signaling pathway; overproductionsuppresses bem1 mutations 0.000220.01175&radic&radic S000005461IZH4YOL101CverifiedMembrane protein involved in zinc metabolism, member of thefour-protein IZH family, expression induced byfatty acids and altered zinc levels; deletionreduces sensitivity to excess zinc; possiblerole in sterol metabolism 0.000220.01175&radic S000005176CSL4YNL232WverifiedSubunit of the exosome, which is an essential complex presentin both nucleus and cytoplasm that mediates RNAprocessing and degradation 0.000220.01172&radic S000003221RTG2YGL252CverifiedSensor of mitochondrial dysfunction; regulates the subcellularlocation of Rtg1p and Rtg3p, transcriptionalactivators of the retrograde (RTG) and TORpathways; Rtg2p is inhibited by thephosphorylated form of Mks1p 0.000220.01172&radic S000005562PEP12YOR036WverifiedTarget membrane receptor (t-SNARE) for vesicular intermediatestraveling between the Golgi apparatus and thevacuole; controls entry of biosynthetic,endocytic, and retrograde traffic into theprevacuolar compartment; syntaxin 0.000220.01172&radic&radic S000001336SER33YIL074Cverified3-phosphoglycerate dehydrogenase, catalyzes the first step inserine and glycine biosynthesis; isozyme ofSer3p 0.000220.0115&radic S000004738RRB1YMR131CverifiedEssential nuclear protein involved in early steps of ribosomebiogenesis; physically interacts with theribosomal protein Rpl3p 0.000220.0115&radic S000004257BOP2YLR267WuncharacterizedProtein of unknown function, overproduction suppresses a pam1slv3 double null mutation 0.000220.0115&radic&radic S000003577NSP1YJL041WverifiedEssential component of the nuclear pore complex, which mediatesnuclear import and export 0.000220.0115&radic&radic S000002232BRE1YDL074CverifiedE3 ubiquitin ligase for Rad6p, required for the ubiquitinationof histone H2B, recruitment of Rad6p topromoter chromatin and subsequent methylationof histone H3 (on L4 and L79), contains RINGfinger domain 0.000220.0115&radic S000004023RSC58YLR033WverifiedRemodels the structure of chromatin complex 58KDa subunit;Chromatin Remodeling Complex subunit 0.000220.0115&radic S000004829SKY1YMR216CverifiedSR protein kinase (SRPK) involved in regulating proteinsinvolved in mRNA metabolism and cationhomeostasis; similar to human SRPK1 0.000220.0115&radic S000000873YER071CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.000220.0115&radic S000005580VHS3YOR054CverifiedFunctionally redundant (see also SIS2) inhibitory subunit ofPpz1p, a PP1c-related ser/thr proteinphosphatase Z isoform; synthetically lethalwith sis2; putative phosphopantothenoylcysteinedecarboxylase involved in coenzyme Abiosynthesis 0.000220.0115&radic S000004894GPI12YMR281WverifiedER membrane protein involved in the second step ofglycosylphosphatidylinositol (GPI) anchorassembly, the de-N-acetylation of theN-acetylglucosaminylphosphatidylinositolintermediate; functional homolog of humanPIG-Lp 0.000220.0115&radic&radic S000000913SWI4YER111CverifiedDNA binding component of the SBF complex (Swi4p-Swi6p), atranscriptional activator that in concert withMBF (Mbp1-Swi6p) regulates late G1-specifictranscription of targets including cyclins andgenes required for DNA synthesis and repair 0.000220.01122&radic S000000909GLE2YER107CverifiedComponent of the nuclear pore complex required forpolyadenylated RNA export but not for proteinimport, homologous to S. pombe Rae1p 0.000220.01122&radic S000001915FAB1YFR019Wverified1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membranekinase that generates phosphatidylinositol(3,5)P2, which is involved in vacuolar sortingand homeostasis 0.000220.01122&radic S000005564HIR2YOR038CverifiedNon-essential transcriptional corepressor involved in the cellcycle-regulated transcription of histone H2A,H2B, H3, and H4 genes; recruits Swi-Snfcomplexes to histone gene promoters; promotesheterochromatic gene silencing with Asf1p 0.000220.01122&radic S000003769TDH2YJR009CverifiedGlyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involvedin glycolysis and gluconeogenesis; tetramerthat catalyzes the reaction ofglyceraldehyde-3-phosphate to 1,3bis-phosphoglycerate; detected in the cytoplasmand cell-wall 0.000220.01122&radic S000000310PHO88YBR106WverifiedProbable membrane protein, involved in phosphate transport;pho88 pho86 double null mutant exhibitsenhanced synthesis of repressible acidphosphatase at high inorganic phosphateconcentrations 0.000220.01122 S000003461SMI1YGR229CverifiedProtein involved in the regulation of cell wall synthesis;proposed to be involved in coordinating cellcycle progression with cell wall integrity 0.000220.01122&radic S000004402VIP1YLR410WverifiedProtein of unknown function probably involved in the functionof the cortical actin cytoskeleton; putativeortholog of S. pombe asp1+ 0.000220.01122&radic S000002867PFA5YDR459CverifiedPalmitoyltransferase with autoacylation activity; likelyfunctions in pathway(s) outside Ras; member ofa family of putative palmitoyltransferasescontaining an Asp-His-His-Cys-cysteine rich(DHHC-CRD) domain 0.000220.01122 S000001675ACP1YKL192CverifiedMitochondrial matrix acyl carrier protein, involved inbiosynthesis of octanoate, which is a precursorto lipoic acid; activated byphosphopantetheinylation catalyzed by Ppt2p 0.000220.01103&radic S000004866YMR253CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene 0.000220.01103&radic S000006306RPL11AYPR102CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl11Bp; involved in ribosomalassembly; depletion causes degradation ofproteins and RNA of the 60S subunit; hassimilarity to E. coli L5 and rat L11 0.000220.01103&radic S000003436ADE3YGR204WverifiedCytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase,involved in single carbon metabolism andrequired for biosynthesis of purines,thymidylate, methionine, and histidine 0.000220.01103&radic S000001566YKL083WDubiousDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14 0.000220.01103 S000006125HRR25YPL204WverifiedProtein kinase involved in regulating diverse events includingvesicular trafficking, gene expression, DNArepair, and chromosome segregation; binds theCTD of RNA pol II; homolog of mammalian caseinkinase 1delta (CK1delta) 0.000220.01103&radic S000000454SPO23YBR250WuncharacterizedProtein of unknown function; associates with meiosis-specificprotein Spo1p 0.000220.01103&radic S000005203ATX1YNL259CverifiedCytosolic copper metallochaperone that transports copper to thesecretory vesicle copper transporter Ccc2p foreventual insertion into Fet3p, which is amulticopper oxidase required for high-affinityiron uptake 0.000220.01103&radic S000006171ICY2YPL250CuncharacterizedProtein of unknown function; potential Cdc28p substrate 0.000220.01103&radic S000004140STM1YLR150WverifiedProtein that binds G4 quadruplex and purine motif triplexnucleic acid; acts with Cdc13p to maintaintelomere structure; interacts with ribosomesand subtelomeric Y' DNA; multicopy suppressorof tom1 and pop2 mutations 0.000210.011&radic S000004640MSN2YMR037CverifiedTranscriptional activator related to Msn4p; activated in stressconditions, which results in translocation fromthe cytoplasm to the nucleus; binds DNA atstress response elements of responsive genes,inducing gene expression 0.000210.011&radic S000001083SRB2YHR041CverifiedGeneral transcription factor, subunit of the RNA polymerase IImediator complex; associates with corepolymerase subunits to form the RNA polymeraseII holoenzyme; involved in telomere maintenance 0.000210.01054&radic S000002461CDC34YDR054CverifiedUbiquitin-conjugating enzyme or E2; together with Skp1p, Rbx1p,Cdc53p, and an F-box protein, forms aubiquitin-protein ligase called the SCF complexwhich regulates cell cycle progression bytargeting key substrates for degradation 0.000210.01054&radic S000005565CKB2YOR039WverifiedBeta' regulatory subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKA2 and CKB1, the many substratesinclude transcription factors and all RNApolymerases 0.000210.01054&radic S000000916BOI2YER114CverifiedProtein implicated in polar growth, functionally redundant withBoi1p; interacts with bud-emergence proteinBem1p; contains an SH3 (src homology 3) domainand a PH (pleckstrin homology) domain 0.000210.01054&radic S000000258YRO2YBR054WverifiedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies;transcriptionally regulated by Haa1p 0.000210.01054 S000000684ABP1YCR088WverifiedActin-binding protein of the cortical actin cytoskeleton,important for activation of the Arp2/3 complexthat plays a key role actin in cytoskeletonorganization 0.000210.01054&radic&radic S000003310PAC10YGR078CverifiedPart of the heteromeric co-chaperone GimC/prefoldin complex,which promotes efficient protein folding 0.000210.01054&radic S000001767TIF1YKR059WverifiedTranslation initiation factor eIF4A, identical to Tif2p;DEA(D/H)-box RNA helicase that couples ATPaseactivity to RNA binding and unwinding; forms adumbbell structure of two compact domainsconnected by a linker; interacts with eIF4G 0.000210.01054&radic S000005892YOR365CUncharacterizedHypothetical protein 0.000210.01054&radic S000003685YJL149WVerifiedPutative SCF ubiquitin ligase F-box protein of unknown function; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C; YJL149W is a non-essential gene 0.000210.01054&radic S000001945YMR31YFR049WverifiedMitochondrial ribosomal protein of the small subunit, hassimilarity to human mitochondrial ribosomalprotein MRP-S36 0.000210.01054&radic S000002918SMT3YDR510WverifiedUbiquitin-like protein of the SUMO family, conjugated to lysineresidues of target proteins; regulateschromatid cohesion, chromosome segregation,APC-mediated proteolysis, DNA replication andseptin ring dynamics 0.000210.00979&radic&radic S000004256PDR8YLR266CverifiedTranscription factor; targets include ATP-binding cassette(ABC) transporters, major facilitatorsuperfamily transporters, and other genesinvolved in the pleiotropic drug resistance(PDR) phenomenon 0.000210.00979&radic&radic S000005796VPH1YOR270CverifiedSubunit of vacuolar-ATPase V0 domain, one of two isoforms(Vph1p and Stv1p); Vph1p is located in V-ATPasecomplexes of the vacuole while Stv1p is locatedin V-ATPase complexes of the Golgi andendosomes 0.000210.00979&radic S000005894SCP1YOR367WverifiedComponent of yeast cortical actin cytoskeleton, binds and crosslinks actin filaments; originally identified byits homology to calponin (contains acalponin-like repeat) but the Scp1p domainstructure is more similar to transgelin 0.000210.00979&radic S000005047MET4YNL103WverifiedLecine-zipper transcriptional activator, responsible for theregulation of the sulfur amino acid pathway,requires different combinations of theauxiliary factors Cbf1p, Met28p, Met31p andMet32p 0.000210.00979&radic S000006142FLC1YPL221WverifiedPutative FAD transporter; required for uptake of FAD intoendoplasmic reticulum; involved in cell wallmaintenance 0.000210.00979&radic&radic S000005855PDR10YOR328WverifiedABC (ATP-binding cassette) membrane pump involved in thepleiotropic drug resistance network, regulatedby Pdr1p and Pdr3p, similar to Pdr5p 0.00020.00979&radic S000000049FLC2YAL053WverifiedPutative FAD transporter; required for uptake of FAD intoendoplasmic reticulum; involved in cell wallmaintenance 0.00020.00979&radic&radic S000005999ATP4YPL078CverifiedSubunit b of the stator stalk of mitochondrial F1F0 ATPsynthase, which is a large, evolutionarilyconserved enzyme complex required for ATPsynthesis 0.000210.00979 S000001871BUD27YFL023WverifiedProtein involved in bud-site selection, nutrient signaling, andgene expression controlled by the TOR kinase;diploid mutants display a random buddingpattern instead of the wild-type bipolarpattern 0.00020.00979&radic S000001125SAM35YHR083WverifiedEssential component of the sorting and assembly machinery (SAMcomplex or TOB complex) of the mitochondrialouter membrane, which binds precursors ofbeta-barrel proteins and facilitates theirinsertion into the outer membrane 0.00020.00979&radic S000004811CIK1YMR198WverifiedKinesin-associated protein required for both karyogamy andmitotic spindle organization, interacts stablyand specifically with Kar3p and may function totarget this kinesin to a specific cellularrole; has similarity to Vik1p 0.000210.00979&radic S000002178RPN4YDL020CverifiedTranscription factor that stimulates expression of proteasomegenes; Rpn4p levels are in turn regulated bythe 26S proteasome in a negative feedbackcontrol mechanism; RPN4 is transcriptionallyregulated by various stress responses 0.000210.00979&radic S000001075YHR033WUncharacterizedPutative protein of unknown function; epitope-tagged protein localizes to the cytoplasm 0.00020.00979&radic S000001131GAR1YHR089CverifiedProtein component of the H/ACA snoRNP pseudouridylase complex,involved in the modification and cleavage ofthe 18S pre-rRNA 0.00020.00979&radic S000002965SMX2YFL017W-AverifiedCore Sm protein Sm G; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm G 0.000210.00979&radic S000000927RSP5YER125WverifiedUbiquitin-protein ligase involved in ubiquitin-mediated proteindegradation; plays a role in heat shock element(HSE)-mediated gene expression andmultivesicular body sorting; contains a hect(homologous to E6-AP carboxyl terminus) domain 0.000210.00979&radic S000003549VTC4YJL012CverifiedVacuolar membrane protein involved in vacuolar polyphosphateaccumulation; functions as a regulator ofvacuolar H+-ATPase activity and vacuolartransporter chaperones; involved innon-autophagic vacuolar fusion 0.000210.00979&radic S000003821CBF1YJR060WverifiedHelix-loop-helix protein that binds the motif CACRTG, which ispresent at several sites including MET genepromoters and centromere DNA element I (CDEI);required for nucleosome positioning at thismotif; targets Isw1p to DNA 0.00020.00967&radic S000001548YET1YKL065CverifiedEndoplasmic reticulum transmembrane protein; may interact withribosomes, based on co-purificationexperiments; homolog of human BAP31 protein 0.00020.00967&radic S000001389YIL127CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus 0.00020.00961&radic S000003492TNA1YGR260WverifiedHigh affinity nicotinic acid plasma membrane permease,responsible for uptake of low levels ofnicotinic acid; expression of the geneincreases in the absence of extracellularnicotinic acid or para-aminobenzoate (PABA) 0.00020.00961 S000004606MVP1YMR004WverifiedProtein required for sorting proteins to the vacuole;overproduction of Mvp1p suppresses severaldominant VPS1 mutations; Mvp1p and Vps1p act inconcert to promote membrane traffic to thevacuole 0.00020.00961&radic&radic S000003155COX4YGL187CverifiedSubunit IV of cytochrome c oxidase, which is the terminalmember of the mitochondrial inner membraneelectron transport chain; N-terminal 25residues of precursor are cleaved duringmitochondrial import 0.00020.00938&radic S000000689CDC39YCR093WverifiedComponent of the CCR4-NOT complex, which has multiple roles inregulating mRNA levels including regulation oftranscription and destabilizing mRNAs bydeadenylation; basal transcription factor 0.00020.00938&radic S000003596BNA3YJL060WverifiedArylformamidase, involved in biosynthesis of nicotinic acidfrom tryptophan via kynurenine pathway;potential Cdc28p substrate 0.00020.00938&radic S000000703RDS1YCR106WverifiedZinc cluster protein involved in conferring resistance tocycloheximide 0.000190.00849&radic S000005791RBL2YOR265WverifiedProtein involved in microtubule morphogenesis, required forprotection from excess free beta-tubulin;proposed to be involved the folding ofbeta-tubulin 0.000190.00849 S000004022RAD5YLR032WverifiedSingle-stranded DNA-dependent ATPase, involved inpostreplication repair; contains RING fingerdomain 0.00020.00849&radic S000000253REB1YBR049CverifiedRNA polymerase I enhancer binding protein; DNA binding proteinwhich binds to genes transcribed by both RNApolymerase I and RNA polymerase II; requiredfor termination of RNA polymerase Itranscription 0.000190.00849&radic S000003703ERG20YJL167WverifiedFarnesyl pyrophosphate synthetase, has bothdimethylallyltranstransferase andgeranyltranstransferase activities; catalyzesthe formation of C15 farnesyl pyrophosphateunits for isoprenoid and sterol biosynthesis 0.000190.00849&radic S000000857HIS1YER055CverifiedATP phosphoribosyltransferase, a hexameric enzyme, catalyzesthe first step in histidine biosynthesis;mutations cause histidine auxotrophy andsensitivity to Cu, Co, and Ni salts;transcription is regulated by general aminoacid control 0.00020.00849&radic S000001491LAC1YKL008CverifiedCeramide synthase component, involved in synthesis of ceramidefrom C26(acyl)-coenzyme A anddihydrosphingosine or phytosphingosine,functionally equivalent to Lag1p 0.00020.00849&radic S000002458YDR051CUncharacterizedHypothetical protein 0.000190.00849 S000005825BUD7YOR299WverifiedMember of the Chs5p-Arf1p-binding proteins (ChAPs), a group of4 related, interacting proteins (Bch1p, Fmp50p,Bud7p, Chs6p) that mediate export of specificcargo proteins, including chitin synthaseChs3p, from the Golgi to plasma membrane 0.000190.00849&radic S000005606DIA2YOR080WverifiedOrigin-binding F-box protein that forms an SCF ubiquitin ligasecomplex with Skp1p and Cdc53p; plays a role inDNA replication, involved in invasive andpseudohyphal growth 0.000190.00849 S000005039YNL095CUncharacterizedPutative protein of unknown function predicted to contain a transmembrane domain; YNL095C is not an essential gene 0.00020.00849&radic S000004916ATM1YMR301CverifiedMitochondrial inner membrane transporter, exportsmitochondrially synthesized precursors ofiron-sulfur (Fe/S) clusters to the cytosol;member of the ATP-binding cassette (ABC)transporter family 0.000190.00849&radic S000003815YJR054WUncharacterizedVacuolar protein of unknown function; potential Cdc28p substrate 0.000190.00849&radic S000007223LUG1YCR087C-AuncharacterizedPutative protein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to thenucleolus; YCR087C-A is not an essential gene 0.000190.00806&radic S000001457YAP5YIR018WverifiedBasic leucine zipper (bZIP) transcription factor 0.000190.00806&radic S000001233ERG9YHR190WverifiedFarnesyl-diphosphate farnesyl transferase (squalene synthase),joins two farnesyl pyrophosphate moieties toform squalene in the sterol biosynthesispathway 0.000190.00806&radic&radic S000004147ASP3-2YLR157CverifiedCell-wall L-asparaginase II, involved in asparagine catabolism;expression is induced during nitrogenstarvation; four copies of ASP3 are present inthe genome reference strain S288C 0.000190.00806&radic S000005007MTQ1YNL063WuncharacterizedS-adenosylmethionine-dependent Methyltransferase; methylatestranslational release factor Mrf1p; similar toE.coli PrmC; is not an essential gene 0.000190.00806&radic S000001863HAC1YFL031WverifiedbZIP transcription factor (ATF/CREB1 homolog) that regulatesthe unfolded protein response, via UPREbinding, and membrane biogenesis; ERstress-induced splicing pathway utilizingIre1p, Trl1p and Ada5p facilitates efficientHac1p synthesis 0.000190.00806&radic S000000770IES6YEL044WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.000190.00806&radic S000001140SFB3YHR098CverifiedMember of the Sec24p family; forms a complex, with Sec23p, thatis involved in sorting of Pma1p into COPIIvesicles; peripheral ER membrane protein;potential Cdc28p substrate 0.000190.00806&radic S000005828YOR302WVerifiedCPA1 uORF , Arginine attenuator peptide, regulates translation of the CPA1 mRNA 0.000180.00793&radic S000001293ULP2YIL031WverifiedPeptidase that deconjugates Smt3/SUMO-1 peptides from proteins,plays a role in chromosome cohesion atcentromeric regions and recovery fromcheckpoint arrest induced by DNA damage or DNAreplication defects; potential Cdc28p substrate 0.000180.00793&radic S000004410CDC73YLR418CverifiedConstituent of Paf1 complex with RNA polymerase II, Paf1p,Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinctfrom Srb-containing Pol II complexes; requiredfor expression of certain genes, modificationof some histones, and telomere maintenance 0.000180.00793 S000004129SLS1YLR139CverifiedMitochondrial membrane protein required for assembly ofrespiratory-chain enzyme complexes III and IV;coordinates expression ofmitochondrially-encoded genes; may facilitatedelivery of mRNA to membrane-bound translationmachinery 0.000190.00793&radic S000003090NAB2YGL122CverifiedNuclear polyadenylated RNA-binding protein; autoregulates mRNAlevels; related to human hnRNPs; has nuclearlocalization signal sequence that binds toKap104p; required for poly(A) tail lengthcontrol and nuclear mRNA export 0.000180.00768&radic S000005291LRO1YNR008WverifiedAcyltransferase that catalyzes diacylglycerol esterification;one of several acyltransferases that contributeto triglyceride synthesis; putative homolog ofhuman lecithin cholesterol acyltransferase 0.000180.00768&radic&radic S000004442HMG2YLR450WverifiedOne of two isozymes of HMG-CoA reductase that convert HMG-CoAto mevalonate, a rate-limiting step in sterolbiosynthesis; overproduction induces assemblyof peripheral ER membrane arrays and shortnuclear-associated membrane stacks 0.000180.00768&radic&radic S000004588YML119WUncharacterizedPutative protein of unknown funtion; YML119W is not an essential gene; potential Cdc28p substrate 0.000180.00768&radic S000002890CWC21YDR482CverifiedComponent of a complex containing Cef1p, putatively involved inpre-mRNA splicing; may bind RNA; has similarityto S. pombe Cwf21p 0.000180.00768&radic&radic S000006127YPL206CUncharacterizedProtein that plays a role in metabolism of glycerophosphocholine to phosphatidylcholine; contains glycerophosphodiester phosphodiesterase motifs 0.000180.00768&radic S000004981NCE103YNL036WverifiedCarbonic anhydrase; poorly transcribed under aerobic conditionsand at an undetectable level under anaerobicconditions; involved in non-classical proteinexport pathway 0.000180.00759&radic&radic&radic S000003906RPS4AYJR145CverifiedProtein component of the small (40S) ribosomal subunit;mutation affects 20S pre-rRNA processing;identical to Rps4Bp and has similarity to ratS4 ribosomal protein 0.000180.00759&radic S000000995LAG1YHL003CverifiedCeramide synthase component, involved in synthesis of ceramidefrom C26(acyl)-coenzyme A anddihydrosphingosine or phytosphingosine,functionally equivalent to Lac1p 0.000180.00759&radic&radic S000005226POP3YNL282WverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends 0.000180.0074&radic S000000372PEX32YBR168WverifiedPeroxisomal integral membrane protein, involved in negativeregulation of peroxisome size; partiallyfunctionally redundant with Pex31p; geneticinteractions suggest action at a stepdownstream of steps mediated by Pex28p andPex29p 0.000180.0074 S000000925YCK3YER123WverifiedPalmitoylated, vacuolar membrane-localized casein kinase Iisoform; negatively regulates vacuole fusionduring hypertonic stress via phosphorylation ofthe HOPS complex subunit, Vps41p; sharesoverlapping essential functions with Hrr25p 0.000180.0074&radic&radic&radic S000006405ARR3YPR201WverifiedArsenite transporter of the plasma membrane, required forresistance to arsenic compounds; transcriptionis activated by Arr1p in the presence ofarsenite 0.000180.00697&radic S000006312RPN7YPR108WverifiedEssential, non-ATPase regulatory subunit of the 26S proteasome,similar to another S. cerevisiae regulatorysubunit, Rpn5p, as well as to mammalianproteasome subunits 0.000180.00697&radic&radic S000004131RRN5YLR141WverifiedProtein involved in transcription of rDNA by RNA polymerase I;transcription factor, member of UAF (upstreamactivation factor) family along with Rrn9p andRrn10p 0.000180.00697&radic S000003247YGR015CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion 0.000180.00697 S000001124KSP1YHR082CverifiedNonessential putative serine/threonine protein kinase ofunknown cellular role; overproduction causesallele-specific suppression of the prp20-10mutation 0.000180.00697&radic S000002939YDR531WUncharacterizedPantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway leading to coenzyme A1 0.000180.00697&radic S000005354YNR071CUncharacterizedHypothetical protein 0.000180.00697 S000004982IDH1YNL037CverifiedSubunit of mitochondrial NAD(+)-dependent isocitratedehydrogenase, which catalyzes the oxidation ofisocitrate to alpha-ketoglutarate in the TCAcycle 0.000180.00697&radic&radic S000004669KAR5YMR065WverifiedProtein required for nuclear membrane fusion during karyogamy,localizes to the membrane with a solubleportion in the endoplasmic reticulum lumen, mayform a complex with Jem1p and Kar2p; expressionof the gene is regulated by pheromone 0.000180.00697 S000001138HXT5YHR096CverifiedHexose transporter with moderate affinity for glucose, inducedin the presence of non-fermentable carbonsources, induced by a decrease in growth rate,contains an extended N-terminal domain relativeto other HXTs 0.000180.00697 S000001380RHO3YIL118WverifiedNon-essential small GTPase of the Rho/Rac subfamily of Ras-likeproteins involved in the establishment of cellpolarity; GTPase activity positively regulatedby the GTPase activating protein (GAP) Rgd1p 0.000170.00673&radic S000003138SPO74YGL170CverifiedComponent of the meiotic outer plaque of the spindle pole body,involved in modifying the meiotic outer plaquethat is required prior to prospore membraneformation 0.000170.00673 S000005804HEM4YOR278WverifiedUroporphyrinogen III synthase, catalyzes the conversion ofhydroxymethylbilane to uroporphyrinogen III,the fourth step in the heme biosyntheticpathway 0.000170.00673&radic&radic S000000601SAT4YCR008WverifiedSer/Thr protein kinase involved in salt tolerance; funtions inregulation of Trk1p-Trk2p potassiumtransporter; partially redundant with Hal5p;has similarity to Npr1p 0.000170.00673 S000003898ECM17YJR137CverifiedSulfite reductase beta subunit, involved in amino acidbiosynthesis, transcription repressed bymethionine 0.000170.00673&radic S000004138PEP3YLR148WverifiedVacuolar peripheral membrane protein that promotes vesiculardocking/fusion reactions in conjunction withSNARE proteins, required for vacuolarbiogenesis, forms complex with Pep5p thatmediates protein transport to the vacuole 0.000170.00673 S000003332MDR1YGR100WverifiedCytoplasmic GTPase-activating protein for Ypt/Rab transportGTPases Ypt6p, Ypt31p and Sec4p; involved inrecycling of internalized proteins andregulation of Golgi secretory function 0.000170.00673 S000002847LRS4YDR439WverifiedProtein involved in rDNA silencing; positively chargedcoiled-coil protein with limited similarity tomyosin 0.000170.00673&radic S000000491ZSP1YBR287WuncharacterizedProtein of unknown function; mutation results in a zincsensitive phenotype 0.000170.00673&radic S000000388YBR184WUncharacterizedPutative protein of unknown function; YBR184W is not an essential gene 0.000170.00673 S000004150ASP3-4YLR160CverifiedCell-wall L-asparaginase II, involved in asparagine catabolism;expression is induced during nitrogenstarvation; four copies of ASP3 are present inthe genome reference strain S288C 0.000170.00673&radic S000005815YOR289WUncharacterizedHypothetical protein 0.000170.00661&radic&radic S000005496PFK27YOL136Cverified6-phosphofructo-2-kinase, catalyzes synthesis offructose-2,6-bisphosphate; inhibited byphosphoenolpyruvate and sn-glycerol3-phosphate, expression induced by glucose andsucrose, transcriptional regulation involvesprotein kinase A 0.000170.00661&radic S000000452HIS7YBR248CverifiedImidazole glycerol phosphate synthase (glutamineamidotransferase:cyclase), catalyzes the fifthand sixth steps of histidine biosynthesis andalso produces 5-aminoimidazole-4-carboxamideribotide (AICAR), a purine precursor 0.000170.00652&radic S000005689DDP1YOR163WverifiedDiadenosine polyphosphate hydrolase, member of the MutT familyof nucleotide hydrolases with high specificityfor diadenosine hexa- and pentaphosphates,required for efficient hydrolysis ofdiphosphorylated inositol polyphosphates 0.000170.00636&radic S000005507PEX11YOL147CverifiedPeroxisomal membrane protein required for peroxisomeproliferation and medium-chain fatty acidoxidation, most abundant protein in theperoxisomal membrane, regulated by Adr1p andPip2p-Oaf1p, promoter contains ORE andUAS1-like elements 0.000170.00636 S000001700JEN1YKL217WverifiedLactate transporter, required for uptake of lactate andpyruvate; expression is derepressed bytranscriptional activator Cat8p undernonfermentative growth conditions, andrepressed in the presence of glucose, fructose,and mannose 0.000170.00636&radic&radic S000006091DAP1YPL170WverifiedHeme-binding protein involved in regulation of cytochrome P450protein Erg11p; damage response protein,related to mammalian membrane progesteronereceptors; mutations lead to defects intelomeres, mitochondria, and sterol synthesis 0.000170.00636&radic S000004868GFD1YMR255WverifiedCoiled-coiled protein of unknown function, identified as ahigh-copy suppressor of a dbp5 mutation 0.000170.00636&radic S000003272KSS1YGR040WverifiedMitogen-activated protein kinase (MAPK) involved in signaltransduction pathways that control filamentousgrowth and pheromone response 0.000170.00636 S000003979YLL056CUncharacterizedPutative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene 0.000160.0061&radic S000000112FUS3YBL016WverifiedMitogen-activated protein kinase involved in mating pheromoneresponse; activated by phosphorylation bySte7p; provides specificity during the matingvs. filamentous growth response byphosphorylating transcriptional and cytoplasmictargets 0.000170.0061&radic S000000979BMH1YER177Wverified14-3-3 protein, major isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others 0.000170.0061&radic S000000991YER189WUncharacterizedHypothetical protein 0.000170.0061&radic S000002438MIC14YDR031WverifiedMitochondrial intermembrane space cysteine motif protein of 14kDa 0.000170.0061 S000002931SPS1YDR523CverifiedPutative protein serine/threonine kinase expressed at the endof meiosis and localized to the prosporemembrane, required for correct localization ofenzymes involved in spore wall synthesis 0.000160.0061 S000001065MYO1YHR023WverifiedType II myosin heavy chain, required for wild-type cytokinesisand cell separation; localizes to theactomyosin ring; binds to myosin light chainsMlc1p and Mlc2p through its IQ1 and IQ2 motifsrespectively 0.000160.0061 S000001914YFR018CUncharacterizedHypothetical protein 0.000170.0061&radic S000004211RSA3YLR221CverifiedProtein with a likely role in ribosomal maturation, requiredfor accumulation of wild-type levels of large(60S) ribosomal subunits; binds to the helicaseDbp6p in pre-60S ribosomal particles in thenucleolus 0.000170.0061 S000004831TRS130YMR218CverifiedOne of 10 subunits of the transport protein particle (TRAPP)complex of the cis-Golgi which mediates vesicledocking and fusion; involved in ER to Golgimembrane traffic; mutation activatestranscription of OCH1 0.000160.0061 S000000440ABD1YBR236CverifiedMethyltransferase, catalyzes the transfer of a methyl groupfrom S-adenosylmethionine to the GpppN terminusof capped mRNA 0.000170.0061 S000000984FMP10YER182WuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.000160.00603 S000003180VAM7YGL212WverifiedComponent of the vacuole SNARE complex involved in vacuolarmorphogenesis; SNAP-25 homolog; functions witha syntaxin homolog Vam3p in vacuolar proteintrafficking 0.000160.00603&radic S000000897RAD51YER095WverifiedStrand exchange protein, forms a helical filament with DNA thatsearches for homology; involved in therecombinational repair of double-strand breaksin DNA during vegetative growth and meiosis;homolog of Dmc1p and bacterial RecA protein 0.000160.00603&radic S000001191IMP3YHR148WverifiedComponent of the SSU processome, which is required for pre-18SrRNA processing, essential protein thatinteracts with Mpp10p and mediates interactionsof Imp4p and Mpp10p with U3 snoRNA 0.000160.00603 S000003745CBP1YJL209WverifiedMitochondrial protein that interacts with the 5'-untranslatedregion of the COB mRNA and has a role in itsstability and translation; found in a complexat the inner membrane along with Pet309p 0.000160.00603&radic S000003666URA2YJL130CverifiedBifunctional carbamoylphosphate synthetase (CPSase)-aspartatetranscarbamylase (ATCase), catalyzes the firsttwo enzymatic steps in the de novo biosynthesisof pyrimidines; both activities are subject tofeedback inhibition by UTP 0.000160.00592 S000004400YLR408CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene 0.000160.00592 S000004809YMR196WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene 0.000160.0058&radic S000003351NUP57YGR119CverifiedEssential subunit of the nuclear pore complex (NPC), functionsas the organizing center of an NPC subcomplexcontaining Nsp1p, Nup49p, Nup57p, and Nic96p 0.000160.0058&radic&radic S000001445PAN1YIR006CverifiedPart of actin cytoskeleton-regulatory complexPan1p-Sla1p-End3p, associates with actinpatches on the cell cortex; promotesprotein-protein interactions essential forendocytosis; previously thought to be a subunitof poly(A) ribonuclease 0.000160.0058&radic S000004656FAR3YMR052WverifiedProtein involved in G1 cell cycle arrest in response topheromone, in a pathway different from theFar1p-dependent pathway; interacts with Far7p,Far8p, Far9p, Far10p, and Far11p 0.000160.0058 S000004279MEC3YLR288CverifiedDNA damage and meiotic pachytene checkpoint protein; subunit ofa heterotrimeric complex (Rad17p-Mec3p-Ddc1p)that forms a sliding clamp, loaded onto partialduplex DNA by a clamp loader complex; homologof human and S. pombe Hus1 0.000160.00541 S000003081SLD3YGL113WverifiedProtein involved in the initiation of DNA replication, requiredfor proper assembly of replication proteins atthe origins of replication; interacts withCdc45p 0.000160.00541 S000004840TAF7YMR227CverifiedTFIID subunit (67 kDa), involved in RNA polymerase IItranscription initiation 0.000160.00541 S000002470YDR063WUncharacterizedHypothetical protein 0.000160.00541 S000001105PAN5YHR063Cverified2-dehydropantoate 2-reductase, part of the pantothenic acidpathway, structurally homologous to E. colipanE 0.000160.00541 S000000479RIF1YBR275CverifiedProtein that binds to the Rap1p C-terminus and actssynergistically with Rif2p to help controltelomere length and establish telomericsilencing; deletion results in telomereelongation 0.000160.00541 S000003106YGL138CUncharacterizedHypothetical protein 0.000160.00541 S000003188YGL220WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus 0.000160.00541&radic S000003717YJL181WUncharacterizedHypothetical protein 0.000160.00541 S000004880PPA2YMR267WverifiedMitochondrial inorganic pyrophosphatase, required formitochondrial function and possibly involved inenergy generation from inorganic pyrophosphate 0.000160.00541 S000001152ERP5YHR110WverifiedProtein with similarity to Emp24p and Erv25p, member of the p24family involved in ER to Golgi transport 0.000160.00541 S000001045YHR003CVerifiedProtein of unknown function, localized to the mitochondrial outer membrane 0.000160.00541 S000001108SSF1YHR066WverifiedConstituent of 66S pre-ribosomal particles, required forribosomal large subunit maturation;functionally redundant with Ssf2p; member ofthe Brix family 0.000160.00541 S000004361SSQ1YLR369WverifiedMitochondrial hsp70-type molecular chaperone, required forassembly of iron/sulfur clusters into proteinsat a step after cluster synthesis, and formaturation of Yfh1p, which is a homolog ofhuman frataxin implicated in Friedreich'sataxia 0.000160.00541 S000006345KAR3YPR141CverifiedMinus-end-directed microtubule motor that functions in mitosisand meiosis, localizes to the spindle pole bodyand localization is dependent on functionalCik1p, required for nuclear fusion duringmating; potential Cdc28p substrate 0.000160.00541 S000004082SUL2YLR092WverifiedHigh affinity sulfate permease; sulfate uptake is mediated byspecific sulfate transporters Sul1p and Sul2p,which control the concentration of endogenousactivated sulfate intermediates 0.000160.00541&radic S000000113PEP1YBL017CverifiedType I transmembrane sorting receptor for multiple vacuolarhydrolases; cycles between the late-Golgi andprevacuolar endosome-like compartments 0.000160.00541&radic S000004841MTF1YMR228WverifiedMitochondrial RNA polymerase specificity factor with structuralsimilarity to S-adenosylmethionine-dependentmethyltransferases and functional similarity tobacterial sigma-factors, interacts withmitochondrial core polymerase Rpo41p 0.000160.00541 S000002202MTF2YDL044CverifiedMitochondrial matrix protein that interacts with an N-terminalregion of mitochondrial RNA polymerase (Rpo41p)and couples RNA processing and translation totranscription 0.000160.00541 S000003136HUR1YGL168WuncharacterizedProtein required for hydroxyurea resistance; has possible rolesin DNA replication and maintenance of propertelomere length 0.000160.00541 S000000371POP7YBR167CverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends 0.000160.00541 S000004141PCD1YLR151CverifiedPeroxisomal nudix pyrophosphatase with specificity for coenzymeA and CoA derivatives, may function to removepotentially toxic oxidized CoA disulfide fromperoxisomes to maintain the capacity forbeta-oxidation of fatty acids 0.000160.00541&radic S000000748GEA2YEL022WverifiedGuanine nucleotide exchange factor for ADP ribosylation factors(ARFs), involved in vesicular transport betweenthe Golgi and ER, Golgi organization, and actincytoskeleton organization; similar to but notfunctionally redundant with Gea1p 0.000160.00541 S000003632MRPL49YJL096WverifiedMitochondrial ribosomal protein of the large subunit 0.000160.00541 S000003200YGL231CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum 0.000160.00541 S000002903VPS3YDR495CverifiedCytoplasmic protein required for the sorting and processing ofsoluble vacuolar proteins, acidification of thevacuolar lumen, and assembly of the vacuolarH+-ATPase 0.000160.00541 S000004873TIF11YMR260CverifiedTranslation initiation factor eIF1A, essential protein thatforms a complex with Sui1p (eIF1) and the 40Sribosomal subunit and scans for the startcodon; C-terminus associates with Fun12p(eIF5B); N terminus interacts with eIF2 andeIF3 0.000150.00533 S000006178YPL257WUncharacterizedHypothetical protein 0.000150.00533 S000003771MET3YJR010WverifiedATP sulfurylase, catalyzes the primary step of intracellularsulfate activation, essential for assimilatoryreduction of sulfate to sulfide, involved inmethionine metabolism 0.000150.00533&radic S000006347RRP15YPR143WverifiedNucleolar protein, constituent of pre-60S ribosomal particles;required for processing of the 27S pre-rRNA atthe A2 site to yield 5.8S and 25S rRNA 0.000150.00533 S000003085YGL117WUncharacterizedPutative protein of unknown function 0.000150.00533 S000005597THI71YOR071CuncharacterizedTransporter of thiamine or related compound; shares sequencesimilarity to Thi7p; proposed to be involved in5-fluorocytosine sensitivity 0.000150.00533 S000001562SMY1YKL079WverifiedProtein that interacts with Myo2p, proposed to be involved inexocytosis; N-terminal domain is related to themotor domain of kinesins 0.000150.00533 S000001004YHL012WUncharacterizedPutative protein of unknown function, has some homology to Ugp1p, which encodes UDP-glucose pyrophosphorylase 0.000150.00525 S000000769YEL043WUncharacterizedPredicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; contains fibronectin type III domain fold 0.000150.00525&radic S000002620TCP1YDR212WverifiedAlpha subunit of chaperonin-containing T-complex, whichmediates protein folding in the cytosol;involved in maintenance of actin cytoskeleton;homolog to Drosophila melanogaster and mousetailless complex polypeptide 0.000150.00525 S000003068SEH1YGL100WverifiedNuclear pore protein that is part of the evolutionarilyconserved Nup84p complex (Nup84p, Nup85p,Nup120p, Nup145p, and Seh1p); homologous toSec13p 0.000150.00525 S000005028END3YNL084CverifiedEH domain-containing protein involved in endocytosis, actincytoskeletal organization and cell wallmorphogenesis; forms a complex with Sla1p andPan1p 0.000150.00518 S000004558UTP14YML093WverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.000150.00518 S000005073NRK1YNL129WverifiedNicotinamide riboside kinase, catalyzes the synthesis ofnicotinamide nucleotide (NMN) from nicotinamideriboside; involved in a salvage pathway forNAD+ biosynthesis 0.000150.00518 S000004416SPP382YLR424WverifiedEssential protein that forms a dimer with Ntr2p; also forms atrimer, with Ntr2p and Prp43p, that is involvedin spliceosome disassembly; found also in amultisubunit complex with the splicing factorClf1p; suppressor of prp38-1 mutation 0.000150.00518 S000004665RNA14YMR061WverifiedCleavage and polyadenylation factor I (CF I) component involvedin cleavage and polyadenylation of mRNA 3'ends; bridges interaction between Rna15p andHrp1p in the CF I complex 0.000150.00518 S000003684RPA34YJL148WverifiedRNA polymerase I subunit A34.5 0.000150.00518 S000005140YNL196CUncharacterizedSporulation-specific protein with a leucine zipper motif 0.000150.00518 S000005204YNL260CUncharacterizedPutative protein of unknown function with similarity to a human protein overexpressed in oral cancers; localizes to the nucleus and cytoplasm; YNL260C is an essential gene 0.000150.00518 S000001674DPH2YKL191WverifiedProtein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p,for synthesis of diphthamide, which is amodified histidine residue of translationelongation factor 2 (Eft1p or Eft2p); may actin a complex with Dph1p and Kti11p 0.000150.00518&radic S000000819AFG3YER017CverifiedComponent, with Yta12p, of the mitochondrial inner membranem-AAA protease that mediates degradation ofmisfolded or unassembled proteins and is alsorequired for correct assembly of mitochondrialenzyme complexes 0.000150.0049&radic S000003336SRB5YGR104CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation; involved intelomere maintenance 0.000150.0049 S000000749YEL023CUncharacterizedPutative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene 0.000150.0049 S000001190MRPL6YHR147CverifiedMitochondrial ribosomal protein of the large subunit 0.000150.0049 S000000623FEN2YCR028CverifiedPlasma membrane H+-pantothenate symporter; confers sensitivityto the antifungal agent fenpropimorph 0.000150.0049&radic S000002396YDL237WUncharacterizedPutative protein of unknown function; YDL237W is not an essential gene 0.000150.0049 S000000697YCR100CUncharacterizedHypothetical protein 0.000150.0049 S000002176ERP3YDL018CverifiedProtein with similarity to Emp24p and Erv25p, member of the p24family involved in ER to Golgi transport