Yfunc lets you browse current and predicted gene functions in yeast

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Prediction of GO:0000350 "formation of catalytic spliceosome for second transesterification step"

GO branch: BP
Number of currently annotated genes: 4

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest TAP:161Giaever:fenpropimorph_1.17uMHarbison:RPH1_SMPS50126IPR003029IPR012340PF00575IPR007502IPR011709PF07717 S000001794PRP16YKR086WverifiedRNA helicase in the DEAH-box family involved in the secondcatalytic step of splicing, exhibitsATP-dependent RNA unwinding activity &radic0.041190.56375&radic&radic&radic S000000815PRP22YER013WverifiedDEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase,associates with lariat intermediates before thesecond catalytic step of splicing; mediatesATP-dependent mRNA release from the spliceosomeand unwinds RNA duplexes &radic0.026180.49521&radic&radic&radic&radic&radic&radic&radic&radic S000004106MSL5YLR116WverifiedComponent of the commitment complex, which defines the firststep in the splicing pathway; essential proteinthat interacts with Mud2p and Prp40p, forming abridge between the intron ends; also involvedin nuclear retention of pre-mRNA 0.017280.41511 S000005294PRP2YNR011CverifiedRNA-dependent ATPase in the DEAH-box family, required foractivation of the spliceosome before the firsttransesterification step in RNA splicing 0.005290.23263&radic&radic&radic S000004735ECM16YMR128WverifiedEssential DEAH-box ATP-dependent RNA helicase specific to theU3 snoRNP, predominantly nucleolar indistribution, required for 18S rRNA synthesis 0.005160.22805&radic&radic&radic S000003088PRP43YGL120CverifiedRNA helicase in the DEAH-box family, functions in both RNApolymerase I and polymerase II transcriptmetabolism, involved in release of thelariat-intron from the spliceosome 0.005060.22354&radic&radic&radic&radic S000004411YLR419WUncharacterizedPutative helicase with limited sequence similarity to human Rb protein; localized to the cytoplasm and the mitochondria; YLR419W is not an essential gene 0.004850.21523&radic&radic&radic S000001561DHR2YKL078WverifiedPredominantly nucleolar DEAH-box RNA helicase, required for 18SrRNA synthesis 0.004580.20432&radic&radic&radic S000001341AIR1YIL079CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p to regulate methylationof Npl3p, which modulates Npl3p function inmRNA processing and export; has similarity toAir2p 0.004010.17953 S000005199GIS2YNL255CverifiedProtein with seven cysteine-rich CCHC zinc-finger motifs,similar to human CNBP, proposed to be involvedin the RAS/cAMP signaling pathway 0.003830.17301 S000002334AIR2YDL175CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p; may regulatemethylation of Npl3p, which modulates Npl3pfunction in mRNA processing and export; hassimilarity to Air1p 0.003790.17083 S000003767SUI2YJR007WverifiedAlpha subunit of the translation initiation factor eIF2,involved in the identification of the startcodon; phosphorylation of Ser51 is required forregulation of translation by inhibiting theexchange of GDP for GTP 0.003120.14478&radic&radic&radic&radic S000004842RRP5YMR229CverifiedProtein required for the synthesis of both 18S and 5.8S rRNA;C-terminal region is crucial for the formationof 18S rRNA and N-terminal region is requiredfor the 5.8S rRNA; component of small ribosomalsubunit (SSU) processosome 0.002790.13146&radic&radic&radic&radic S000002495SLU7YDR088CverifiedRNA splicing factor, required for ATP-independent portion of2nd catalytic step of spliceosomal RNAsplicing; interacts with Prp18p; contains zincknuckle domain &radic0.002730.12889&radic&radic S000002812RPB7YDR404CverifiedRNA polymerase II subunit B16; forms two subunit dissociablecomplex with Rpb4p 0.002360.11425&radic&radic&radic S000000939YER137CUncharacterizedHypothetical protein 0.002310.11222 S000005502RRP40YOL142WverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex 0.002130.10505&radic&radic S000005381DIS3YOL021CverifiedNucleolar exosome component, involved in rRNA processing andRNA degradation, binds Gsp1p/Ran and enhancesthe GEF activity of Srm1p, implicated inmitotic control, homologous to the E. coliRNase R of the RNase II family 0.002050.10105&radic&radic&radic S000003238PRP18YGR006WverifiedSplicing factor involved in the positioning of the 3' splicesite during the second catalytic step ofsplicing, recruited to the spliceosome by Slu7p &radic0.002020.09967&radic S000001803MLP1YKR095WverifiedMyosin-like protein associated with the nuclear envelope,connects the nuclear pore complex with thenuclear interior; involved with Tel1p intelomere length control; involved with Pml1pand Pml39p in nuclear retention of unsplicedmRNAs 0.001840.0924 S000000974BRR2YER172CverifiedRNA-dependent ATPase RNA helicase involved in the facilitationand disruption of snRNA interactions, requiredfor disruption of U4/U6 base-pairing in nativesnRNPs to activate the spliceosome forcatalysis 0.001770.08874 S000001111RRP4YHR069CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp41p, Rrp42p,Rrp43p and Dis3p 0.001780.08874&radic&radic&radic S000006311YTH1YPR107CverifiedEssential RNA-binding component of cleavage and polyadenylationfactor, contains five zinc fingers; requiredfor pre-mRNA 3'-end processing andpolyadenylation 0.001720.08647 S000001542MPE1YKL059CverifiedEssential conserved subunit of CPF (cleavage andpolyadenylation factor), plays a role in 3' endformation of mRNA via the specific cleavage andpolyadenylation of pre-mRNA, contains aputative RNA-binding zinc knuckle motif 0.001650.08329 S000002772CDC40YDR364CverifiedPre-mRNA splicing factor, important for catalytic step II ofpre-mRNA splicing and plays a role in cellcycle progression; required for DNA synthesisduring mitosis and meiosis; has WD repeats 0.001480.07434 S000004107CLF1YLR117CverifiedEssential splicesome assembly factor; contains multipletetratricopeptide repeat (TPR) protein-bindingmotifs and interacts specifically with manyspliceosome components, may serve as a scaffoldduring splicesome assembly 0.000980.04451&radic S000001208PRP8YHR165CverifiedComponent of the U4/U6-U5 snRNP complex, involved in the secondcatalytic step of splicing 0.000920.04181&radic S000000467SHM1YBR263WverifiedMitochondrial serine hydroxymethyltransferase, involved inone-carbon metabolism 0.000790.03639 S000001042YHL050CUncharacterizedPutative protein of unknown function, potential Cdc28p substrate 0.000770.03536 S000000269ECM2YBR065CverifiedPre-mRNA splicing factor, facilitates the cooperative formationof U2/U6 helix II in association with stem IIin the spliceosome, function may be regulatedby Slu7p 0.000740.03454&radic S000004802SGS1YMR190CverifiedNucleolar DNA helicase of the RecQ family involved inmaintenance of genome integrity, regulateschromosome synapsis and meiotic crossing over;has similarity to human BLM and WRN helicasesimplicated in Bloom and Werner syndromes 0.000740.03444 S000001441MPH1YIR002CverifiedMember of the DEAH family of helicases, functions in anerror-free DNA damage bypass pathway thatinvolves homologous recombination, mutationsconfer a mutator phenotype 0.000740.03444 S000000449ISW1YBR245CverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPase thatforms a complex with Ioc2p and Ioc4p toregulate transcription elongation, and acomplex with Ioc3p to repress transcriptioninitiation 0.000730.03347 S000003149GTS1YGL181WverifiedProtein containing a zinc-finger in the N-terminus and a longGln-rich region in the C-terminus; regulatesultradian rhythm, cell size, cell cycle,lifespan, sporulation, heat tolerance, andmultidrug transport 0.00070.03258 S000001725YKR017CUncharacterizedPutative protein of unknown function; contains a RING finger motif 0.00070.03258 S000002701SSD1YDR293CverifiedProtein with a role in maintenance of cellular integrity,interacts with components of the TOR pathway;ssd1 mutant of a clinical S. cerevisiae straindisplays elevated virulence 0.000630.03022 S000005929CHL1YPL008WverifiedConserved nuclear protein required to establishsister-chromatid pairing during S-phase,probable DNA helicase with similarity to humanBACH1, which associates with tumor suppressorBRCA1; associates with acetyltransferase Ctf7p 0.000610.02921 S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.000560.02659 S000003506TAF1YGR274CverifiedTFIID subunit (145 kDa), involved in RNA polymerase IItranscription initiation, has histoneacetyltransferase activity, involved inpromoter binding and G1/S progression 0.000550.0265 S000004826CEF1YMR213WverifiedEssential splicing factor; associated with Prp19p and thespliceosome, contains an N-terminal c-Myb DNAbinding motif necessary for cell viability butnot for Prp19p association, evolutionarilyconserved and homologous to S. pombe Cdc5p 0.000520.02512&radic S000004425CNA1YLR433CverifiedCalcineurin A; one isoform (the other is CMP2) of the catalyticsubunit of calcineurin, aCa++/calmodulin-regulated protein phosphatasewhich regulates Crz1p (a stress-responsetranscription factor), the other calcineurinsubunit is CNB1 0.000520.02512 S000000318RAD16YBR114WverifiedProtein that recognizes and binds damaged DNA in anATP-dependent manner (with Rad7p) duringnucleotide excision repair; subunit ofNucleotide Excision Repair Factor 4 (NEF4);member of the SWI/SNF family 0.00050.02252 S000002368CWC2YDL209CverifiedProtein involved in pre-mRNA splicing, component of a complexcontaining Cef1p; interacts with Prp19p;contains an RNA recognition motif; hassimilarity to S. pombe Cwf2p 0.000480.02184&radic S000003704SET2YJL168CverifiedHistone methyltransferase with a role in transcriptionalelongation, methylates a lysine residue ofhistone H3; associates with the C-terminaldomain of Rpo21p; histone methylation activityis regulated by phosphorylation status ofRpo21p 0.000470.02024 S000003464NAS6YGR232WverifiedRegulatory, non-ATPase subunit of the 26S proteasome; homologof the human oncoprotein gankyrin, whichinteracts with the retinoblastoma tumorsuppressor (Rb) and cyclin-dependent kinase 4/6 0.000460.01955 S000001732DBP7YKR024CverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in ribosomal biogenesis 0.000460.01955 S000000973RAD3YER171Wverified5' to 3' DNA helicase, involved in nucleotide excision repairand transcription; subunit of RNA polymerase IItranscription initiation factor TFIIH; subunitof Nucleotide Excision Repair Factor 3 (NEF3);homolog of human XPD protein 0.000440.01907 S000002172NOP1YDL014WverifiedNucleolar protein, component of the small subunit processomecomplex, which is required for processing ofpre-18S rRNA; has similarity to mammalianfibrillarin 0.000440.0189 S000001072SLT2YHR030CverifiedSerine/threonine MAP kinase involved in regulating themaintenance of cell wall integrity andprogression through the cell cycle; regulatedby the PKC1-mediated signaling pathway 0.000440.0189 S000004422SEN1YLR430WverifiedPutative helicase required for RNA polymerase II transcriptiontermination and processing of RNAs; homolog ofSenataxin which causes Ataxia-OculomotorApraxia 2 and a dominant form of amyotrophiclateral sclerosis 0.000430.01861 S000002517FOB1YDR110WverifiedNucleolar protein required for DNA replication fork blockingand recombinational hotspot activities; bindsto the replication fork barrier site in therDNA region; related to retroviral integrases 0.000430.01857 S000001656SNU114YKL173WverifiedGTPase component of U5 snRNP involved in mRNA splicing viaspliceosome; binds directly to U5 snRNA;proposed to be involved in conformationalchanges of the spliceosome; similarity toribosomal translocation factor EF-2 0.000390.01537&radic S000004618SOK2YMR016CverifiedNuclear protein that plays a regulatory role in the cyclic AMP(cAMP)-dependent protein kinase (PKA) signaltransduction pathway; negatively regulatespseudohyphal differentiation; homologous toseveral transcription factors 0.000390.01537 S000002280UBP1YDL122WverifiedUbiquitin-specific protease that removes ubiquitin fromubiquitinated proteins; cleaves at the Cterminus of ubiquitin fusions irrespective oftheir size; capable of cleaving polyubiquitinchains 0.000380.01452 S000005937SWI1YPL016WverifiedSubunit of the SWI/SNF chromatin remodeling complex, whichregulates transcription by remodelingchromosomes; required for transcription of manygenes, including ADH1, ADH2, GAL1, HO, INO1 andSUC2 0.000380.01408 S000000030PRP45YAL032CverifiedProtein required for pre-mRNA splicing; associates with thespliceosome and interacts with splicing factorsPrp22p and Prp46p; orthologous to humantranscriptional coactivator SKIP and canactivate transcription of a reporter gene 0.000380.01408 S000000805PMI40YER003CverifiedMannose-6-phosphate isomerase, catalyzes the interconversion offructose-6-P and mannose-6-P; required forearly steps in protein mannosylation 0.000380.01408 S000003318PIL1YGR086CverifiedPrimary component of eisosomes, which are large immobile patchstructures at the cell cortex associated withendocytosis, along with Lsp1p and Sur7p; nullmutants show activation of Pkc1p/Ypk1p stressresistance pathways 0.000370.0138 S000003202SEC15YGL233WverifiedEssential 113kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which mediates polarized targeting ofvesicles to active sites of exocytosis; Sec15passociates with Sec4p and vesicles 0.000360.01319 S000001065MYO1YHR023WverifiedType II myosin heavy chain, required for wild-type cytokinesisand cell separation; localizes to theactomyosin ring; binds to myosin light chainsMlc1p and Mlc2p through its IQ1 and IQ2 motifsrespectively 0.000330.01155 S000005119NOP13YNL175CverifiedProtein of unknown function, localizes to the nucleolus andnucleoplasm; contains an RNA recognition motif(RRM) and has similarity to Nop12p, which isrequired for processing of pre-18S rRNA 0.000330.01128 S000002726MCM21YDR318WverifiedProtein involved in minichromosome maintenance; component ofthe COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p)that bridges kinetochore subunits that are incontact with centromeric DNA and the subunitsbound to microtubules 0.000330.01084 S000006132NIP7YPL211WverifiedNucleolar protein required for 60S ribosome subunit biogenesis,constituent of 66S pre-ribosomal particles;physically interacts with Nop8p and the exosomesubunit Rrp43p 0.000320.01084 S000003959PRP19YLL036CverifiedSplicing factor associated with the spliceosome; contains aU-box, a motif found in a class of ubiquitinligases 0.000310.00936&radic S000006305SNT309YPR101WverifiedComponent of NineTeen complex (NTC) containing Prp19p involvedin mRNA splicing, interacts physically andgenetically with Prp19p 0.00030.00851&radic S000002303YDL144CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene. 0.000270.00615 S000003306SMD1YGR074WverifiedCore Sm protein Sm D1; part of heteroheptameric complex (withSmb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D1 0.000190.00247&radic S000001094CIC1YHR052WverifiedEssential protein that interacts with proteasome components andhas a potential role in proteasome substratespecificity; also copurifies with 66Spre-ribosomal particles 0.000110.00161 S000000950SPT15YER148WverifiedTATA-binding protein, general transcription factor thatinteracts with other factors to form thepreinitiation complex at promoters, essentialfor viability 0.000110.00161 S000003393RTS3YGR161CuncharacterizedPutative component of the protein phosphatase type 2A complex 0.000110.0016 S000003866ADO1YJR105WverifiedAdenosine kinase, required for the utilization ofS-adenosylmethionine (AdoMet); may be involvedin recycling adenosine produced through themethyl cycle 0.000110.0016 S000004171VTA1YLR181CverifiedMultivesicular body (MVB) protein involved in endosomal proteinsorting; binds to Vps20p and Vps4p; mayregulate Vps4p function; bindsVps60p and mayact at a late step in MVB formation; mutantsshow class E vacuolar-protein sorting defects 0.000110.00159 S000006138BMS1YPL217CverifiedEssential conserved nucleolar GTP-binding protein required forsynthesis of 40S ribosomal subunits and forprocessing of the 35S pre-rRNA at sites A0, A1,and A2; interacts with Rcl1p, has similarity toTsr1p 0.000110.00158 S000003119NUT1YGL151WverifiedComponent of the RNA polymerase II mediator complex, which isrequired for transcriptional activation andalso has a role in basal transcription 0.000110.00158 S000001791DAD2YKR083CverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; is transferred to thekinetochore prior to mitosis 0.000110.00158 S000000605PGK1YCR012Wverified3-phosphoglycerate kinase, catalyzes transfer of high-energyphosphoryl groups from the acyl phosphate of1,3-bisphosphoglycerate to ADP to produce ATP;key enzyme in glycolysis and gluconeogenesis 0.000110.00158 S000005008YDJ1YNL064CverifiedProtein chaperone involved in regulation of the HSP90 and HSP70functions; involved in protein translocationacross membranes; member of the DnaJ family 0.000110.00158 S000004616BUD22YMR014WverifiedProtein involved in bud-site selection; diploid mutants displaya random budding pattern instead of thewild-type bipolar pattern 0.000110.00158 S000003854IME1YJR094CverifiedMaster regulator of meiosis that is active only during meioticevents, activates transcription of earlymeiotic genes through interaction with Ume6p,degraded by the 26S proteasome followingphosphorylation by Ime2p 0.000110.00158 S000002223PEX19YDL065CverifiedChaperone and import receptor for newly-synthesized class Iperoxisomal membrane proteins (PMPs), bindsPMPs in the cytoplasm and delivers them to theperoxisome for subsequent insertion into theperoxisomal membrane 0.000110.00158 S000007548YCL026C-BUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 0.000110.00157 S000000612MAK32YCR019WverifiedProtein necessary for structural stability of L-Adouble-stranded RNA-containing particles 0.000110.00157 S000001122YHR080CUncharacterizedPutative protein of unknown function; localizes to the mitochondrion 0.000110.00157 S000028548YGL041C-BUncharacterizedIdentified by fungal homology and RT-PCR 0.000110.00157 S000003850GRR1YJR090CverifiedF-box protein component of the SCF ubiquitin-ligase complex,required for Cln1p and Cln2p degradation;involved in carbon catabolite repression,glucose-dependent divalent cation transport,high-affinity glucose transport, andmorphogenesis 0.00010.00154 S000003985MHT1YLL062CverifiedS-methylmethionine-homocysteine methyltransferase, functionsalong with Sam4p in the conversion ofS-adenosylmethionine (AdoMet) to methionine tocontrol the methionine/AdoMet ratio 0.00010.00154 S000005409GSH2YOL049WverifiedGlutathione synthetase, catalyzes the ATP-dependent synthesisof glutathione (GSH) fromgamma-glutamylcysteine and glycine; induced byoxidative stress and heat shock 0.00010.00154 S000006094MRPL40YPL173WverifiedMitochondrial ribosomal protein of the large subunit 0.00010.00154 S000002485SHU2YDR078CuncharacterizedProtein of unassigned function involved in mutationsuppression, important for error-free repair ofspontaneous and induced DNA lesions to protectthe genome from mutation; associates withShu1p, Psy3p, and Csm2p 0.00010.00154 S000001229KOG1YHR186CverifiedSubunit of TORC1, a rapamycin-sensitive complex involved ingrowth control that contains Tor1p or Tor2p,Lst8p and Tco89p; contains four HEAT repeatsand seven WD-40 repeats; may act as a scaffoldprotein to couple TOR and its effectors 0.00010.00154 S000003178YPT32YGL210WverifiedGTPase of the Ypt/Rab family, very similar to Ypt31p; involvedin the exocytic pathway; mediates intra-Golgitraffic or the budding of post-Golgi vesiclesfrom the trans-Golgi 0.00010.00154 S000000697YCR100CUncharacterizedHypothetical protein 0.00010.00154 S000007235SEM1YDR363W-AverifiedComponent of the lid subcomplex of the regulatory subunit ofthe 26S proteasome; ortholog of human DSS1 0.00010.00154 S000001701SRY1YKL218Cverified3-hydroxyaspartate dehydratase, deaminatesL-threo-3-hydroxyaspartate to form oxaloacetateand ammonia; required for survival in thepresence of hydroxyaspartate 0.00010.00154 S000001313MMF1YIL051CverifiedMitochondrial protein involved in maintenance of themitochondrial genome 0.00010.00154 S000000992YRF1-2YER190WverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p 0.00010.00154 S000005096YNL152WUncharacterizedProtein required for cell viability 0.00010.00154 S000004940YMR321CUncharacterizedHypothetical protein 0.00010.00154 S000028836YIL046W-AUncharacterizedPutative protein of unknown function; identified by expression profiling and mass spectrometry 0.00010.00154 S000003176SIP2YGL208WverifiedOne of three beta subunits of the Snf1 serine/threonine proteinkinase complex involved in the response toglucose starvation; null mutants exhibitaccelerated aging; N-myristoylprotein localizedto the cytoplasm and the plasma membrane 0.00010.00154 S000004885SCS7YMR272CverifiedSphingolipid alpha-hydroxylase, functions in thealpha-hydroxylation of sphingolipid-associatedvery long chain fatty acids, has bothcytochrome b5-like and hydroxylase/desaturasedomains, not essential for growth 0.00010.00154 S000004198SEC13YLR208WverifiedComponent of both the Nup84 nuclear pore sub-complex and of theCOPII complex (Sar1p, Sec13p, Sec16p, Sec23p,Sec24p, Sec31p, Sfb2p, and Sfb3p) which isimportant for the formation of ER to Golgitransport vesicles 0.00010.00154 S000001642RCN1YKL159CverifiedProtein involved in calcineurin regulation during calciumsignaling; has similarity to H. sapiens DSCR1which is found in the Down Syndrome candidateregion 0.00010.00154 S000003143SAE2YGL175CverifiedProtein with a role in accurate meiotic and mitoticdouble-strand break repair; phosphorylated inresponse to DNA damage and required for normalresistance to DNA-damaging agents 0.00010.00154 S000002354SEC31YDL195WverifiedEssential phosphoprotein component (p150) of the COPII coat ofsecretory pathway vesicles, in complex withSec13p; required for ER-derived transportvesicle formation 0.00010.00154 S000006003MOT1YPL082CverifiedEssential abundant protein involved in regulation oftranscription, removes Spt15p (TBP) from DNAvia its C-terminal ATPase activity, forms acomplex with TBP that binds TATA DNA with highaffinity but with altered specificity 0.00010.00154 S000002242SUB2YDL084WverifiedComponent of the TREX complex required for nuclear mRNA export;member of the DEAD-box RNA helicase superfamilyand is involved in early and late steps ofspliceosome assembly; homolog of the humansplicing factor hUAP56 0.00010.00154 S000002583NGG1YDR176WverifiedTranscriptional regulator involved in glucose repression ofGal4p-regulated genes; component oftranscriptional adaptor and histoneacetyltransferase complexes, the ADA complex,the SAGA complex, and the SLIK complex 0.00010.00154 S000006115DDC1YPL194WverifiedDNA damage checkpoint protein, part of a PCNA-like complexrequired for DNA damage response, required forpachytene checkpoint to inhibit cell cycle inresponse to unrepaired recombinationintermediates; potential Cdc28p substrate 0.00010.00154 S000000669SSK22YCR073CverifiedMAP kinase kinase kinase of the HOG1 mitogen-activatedsignaling pathway; functionally redundant with,and homologous to, Ssk2p; interacts with and isactivated by Ssk1p; phosphorylates Pbs2p 0.00010.00154 S000005756WTM1YOR230WverifiedTranscriptional repressor involved in regulation of meiosis andsilencing; contains WD repeats 0.00010.00154 S000003624ARG3YJL088WverifiedOrnithine carbamoyltransferase (carbamoylphosphate:L-ornithinecarbamoyltransferase), catalyzes the sixth stepin the biosynthesis of the arginine precursorornithine 0.00010.00154 S000001750UTH1YKR042WverifiedMitochondrial outer membrane and cell wall localized SUN familymember required for mitochondrial autophagy;involved in the oxidative stress response, lifespan during starvation, mitochondrialbiogenesis, and cell death 0.00010.00152 S000003821CBF1YJR060WverifiedHelix-loop-helix protein that binds the motif CACRTG, which ispresent at several sites including MET genepromoters and centromere DNA element I (CDEI);required for nucleosome positioning at thismotif; targets Isw1p to DNA 0.00010.00152 S000003399CLC1YGR167WverifiedClathrin light chain, subunit of the major coat proteininvolved in intracellular protein transport andendocytosis; thought to regulate clathrinfunction, two Clathrin heavy chains (CHC1) formthe clathrin triskelion structural component 0.00010.00152 S000000283RPG1YBR079CverifiedSubunit of the core complex of translation initiation factor3(eIF3), essential for translation; part of asubcomplex (Prt1p-Rpg1p-Nip1p) that stimulatesbinding of mRNA and tRNA(i)Met to ribosomes 0.00010.00152 S000005553STI1YOR027WverifiedHsp90 cochaperone, interacts with the Ssa group of thecytosolic Hsp70 chaperones; activates theATPase activity of Ssa1p; homolog of mammalianHop protein 0.00010.00152 S000006130IPL1YPL209CverifiedAurora kinase involved in regulating kinetochore-microtubuleattachments; helps maintain condensedchromosomes during anaphase and earlytelophase; associates with Sli15p, whichpromotes Ipl1p association with mitotic spindle 0.00010.00152 S000005800MOD5YOR274WverifiedDelta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase,required for biosynthesis of the modified baseisopentenyladenosine in mitochondrial andcytoplasmic tRNAs; gene is nuclear and encodestwo isozymic forms 0.00010.00152 S000005098YCK2YNL154CverifiedPalmitoylated, plasma membrane-bound casein kinase I isoform;shares redundant functions with Yck1p inmorphogenesis, proper septin assembly,endocytic trafficking; provides an essentialfunction overlapping with that of Yck1p 0.00010.00152 S000004581DAT1YML113WverifiedDNA binding protein that recognizes oligo(dA).oligo(dT) tracts;Arg side chain in its N-terminal pentadGly-Arg-Lys-Pro-Gly repeat is required forDNA-binding; not essential for viability 0.00010.00152 S000000514STP22YCL008CverifiedComponent of the ESCRT-I complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; homologous to the mouse and humanTsg101 tumor susceptibility gene; mutantsexhibit a Class E Vps phenotype 0.00010.00152 S000004363ROM2YLR371WverifiedGDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutationsare synthetically lethal with mutations inrom1, which also encodes a GEP 0.00010.00152 S000000465YBR261CUncharacterizedPutative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBR261C is not an essential gene 0.00010.00152 S000002678CCC2YDR270WverifiedCu(+2)-transporting P-type ATPase, required for export ofcopper from the cytosol into an extracytosoliccompartment; has similarity to human proteinsinvolved in Menkes and Wilsons diseases 0.00010.00152 S000002644FMN1YDR236CverifiedRiboflavin kinase, phosphorylates riboflavin to form riboflavinmonophosphate (FMN), which is a necessarycofactor for many enzymes; localizes tomicrosomes and to the mitochondrial innermembrane 0.00010.00152 S000003448GPI1YGR216CverifiedMembrane protein involved in the synthesis ofN-acetylglucosaminyl phosphatidylinositol(GlcNAc-PI), the first intermediate in thesynthesis of glycosylphosphatidylinositol (GPI)anchors; human and mouse GPI1p are functionalhomologs 0.00010.00152 S000002537FIN1YDR130CverifiedSpindle pole body-related intermediate filament protein, formscell cycle-specific filaments between spindlepole bodies in mother and daughter cells, ableto self-assemble, expression induced duringS/G2, localization cell-cycle dependent 0.00010.00152 S000003039AFT1YGL071WverifiedTranscription factor involved in iron utilization andhomeostasis; binds the consensus sitePyPuCACCCPu and activates the expression oftarget genes in response to changes in ironavailability 0.00010.00152 S000007242YKL033W-AUncharacterizedPutative protein of unknown function; similar to uncharacterized proteins from other fungi 0.00010.00152 S000003445RTA1YGR213CverifiedProtein involved in 7-aminocholesterol resistance; has sevenpotential membrane-spanning regions 0.00010.00152 S000005300MAS6YNR017WverifiedEssential protein of the mitochondrial inner membrane,component of the mitochondrial import system 0.00010.00152 S000000746YEL020CUncharacterizedHypothetical protein with low sequence identity to Pdc1p 0.00010.00152 S000002408NTH1YDR001CverifiedNeutral trehalase, degrades trehalose; required forthermotolerance and may mediate resistance toother cellular stresses; may be phosphorylatedby Cdc28p 0.00010.00152 S000004306CDC3YLR314CverifiedComponent of the septin ring of the mother-bud neck that isrequired for cytokinesis; septins recruitproteins to the neck and can act as a barrierto diffusion at the membrane, and they comprisethe 10nm filaments seen with EM 0.00010.00152 S000004628PEX12YMR026CverifiedRING-finger peroxisomal membrane peroxin that plays anessential role in peroxisome biogenesis andperoxisomal matrix protein import, formstranslocation subcomplex with Pex2p and Pex10p 0.00010.00152 S000001332MAM33YIL070CverifiedAcidic protein of the mitochondrial matrix involved inoxidative phosphorylation; related to the humancomplement receptor gC1q-R 0.00010.00152 S000003836HOC1YJR075WverifiedAlpha-1,6-mannosyltransferase involved in cell wall mannanbiosynthesis; subunit of a Golgi-localizedcomplex that also contains Anp1p, Mnn9p,Mnn11p, and Mnn10p; identified as a suppressorof a cell lysis sensitive pkc1-371 allele 0.00010.00152 S000007281COX2Q0250verifiedSubunit II of cytochrome c oxidase, which is the terminalmember of the mitochondrial inner membraneelectron transport chain; one of threemitochondrially-encoded subunits 0.00010.00152 S000004851DFG5YMR238WverifiedPutative mannosidase, essential glycosylphosphatidylinositol(GPI)-anchored membrane protein required forcell wall biogenesis in bud formation, involvedin filamentous growth, homologous to Dcw1p 0.00010.00152 S000002643PRP42YDR235WverifiedU1 snRNP protein involved in splicing, required for U1 snRNPbiogenesis; contains multipletetriatricopeptide repeats 0.00010.00152&radic S000004779ALD3YMR169CverifiedCytoplasmic aldehyde dehydrogenase, involved in beta-alaninesynthesis; uses NAD+ as the preferred coenzyme;very similar to Ald2p; expression is induced bystress and repressed by glucose 0.00010.00152 S000002372NOP6YDL213CuncharacterizedProtein with similarity to hydrophilins, which are involved inthe adaptive response to hyperosmoticconditions; computational analysis oflarge-scale protein-protein interaction datasuggests a possible role in rRNA processing 0.00010.00152 S000001885CDC4YFL009WverifiedF-box protein required for G1/S and G2/M transition, associateswith Skp1p and Cdc53p to form a complex,SCFCdc4, which acts as ubiquitin-protein ligasedirecting ubiquitination of the phosphorylatedCDK inhibitor Sic1p 0.00010.00152 S000005611OST3YOR085WverifiedGamma subunit of the oligosaccharyltransferase complex of theER lumen, which catalyzes asparagine-linkedglycosylation of newly synthesized proteins;Ost3p is important for N-glycosylation of asubset of proteins 0.00010.00152 S000001718TOF2YKR010CverifiedNonessential mitochondrial protein of unknown function withsequence similarity to Net1p; identified as atopoisomerase I (Top1p) binding protein;displays synthetic genetic interactions withTOP1 and HPR1 0.00010.00152 S000002356ASF2YDL197CverifiedAnti-silencing protein that causes derepression of silent lociwhen overexpressed 0.00010.00152 S000000150YBL054WUncharacterizedHypothetical protein 0.00010.00152 S000003690VPS35YJL154CverifiedEndosomal subunit of membrane-associated retromer complexrequired for retrograde transport; receptorthat recognizes retrieval signals on cargoproteins, forms subcomplex with Vps26p andVps29p that selects cargo proteins forretrieval 0.00010.00152 S000002197PRM7YDL039CverifiedPheromone-regulated protein, predicted to have onetransmembrane segment; promoter contains Gcn4pbinding elements 0.00010.00152 S000003111MRF1YGL143CverifiedMitochondrial polypeptide chain release factor, involved instop codon recognition and hydrolysis of thepeptidyl-tRNA bond during mitochondrialtranslation; lack of MRF1 causes mitochondrialgenome instability 0.00010.00152 S000003493APL6YGR261CverifiedBeta3-like subunit of the yeast AP-3 complex; functions intransport of alkaline phosphatase to thevacuole via the alternate pathway; exists inboth cytosolic and peripherally associatedmembrane-bound pools 0.00010.00152 S000000233CDS1YBR029CverifiedPhosphatidate cytidylyltransferase (CDP-diglyceridesynthetase); an enzyme that catalyzes thatconversion of CTP + phosphate into diphosphate+ CDP-diaclglyerol, a critical step in thesynthesis of all major yeast phospholipids 0.00010.00152 S000006287MDM36YPR083WverifiedProtein required for normal mitochondrial morphology andinheritance 0.00010.00152 S000005963SSN3YPL042CverifiedCyclin-dependent protein kinase, component of RNA polymerase IIholoenzyme; involved in phosphorylation of theRNA polymerase II C-terminal domain; involvedin glucose repression 0.00010.00152 S000003094SCS3YGL126WverifiedProtein required for inositol prototrophy, appears to beinvolved in the synthesis of inositolphospholipids from inositol but not in thecontrol of inositol synthesis 0.00010.00152 S000000813TIR1YER011WverifiedCell wall mannoprotein of the Srp1p/Tip1p family ofserine-alanine-rich proteins; expression isdownregulated at acidic pH and induced by coldshock and anaerobiosis; abundance is increasedin cells cultured without shaking 0.00010.00152 S000005515HPF1YOL155CverifiedHaze-protective mannoprotein that reduces the particle size ofaggregated proteins in white wines 0.00010.0015 S000001165EPT1YHR123Wverifiedsn-1,2-diacylglycerol ethanolamine- andcholinephosphotranferase; not essential forviability 0.00010.0015 S000000021PMT2YAL023CverifiedProtein O-mannosyltransferase, transfers mannose residues fromdolichyl phosphate-D-mannose to proteinserine/threonine residues; acts in a complexwith Pmt1p, can instead interact with Pmt5p insome conditions; target for new antifungals 0.00010.0015 S000087209YDR461C-AUncharacterizedPutative protein of unknown function 0.00010.0015 S000005584ASE1YOR058CverifiedMember of a family of microtubule-associated proteins (MAPs)that function at the mitotic spindle midzone;required for spindle elongation; undergoes cellcycle-regulated degradation by anaphasepromoting complex; potential Cdc28p substrate 0.00010.0015 S000006393SKI3YPR189WverifiedProtein involved in exosome mediated 3' to 5' mRNA degradationand translation inhibition of non-poly(A)mRNAs; forms complex with Ski2p and Ski8p;required for repressing propagation of dsRNAviruses 0.00010.0015 S000003664PBS2YJL128CverifiedMAP kinase kinase that plays a pivotal role in the osmosensingsignal-transduction pathway, activated undersevere osmotic stress 0.00010.0015 S000001880HSP12YFL014WverifiedPlasma membrane localized protein that protects membranes fromdesiccation; induced by heat shock, oxidativestress, osmostress, stationary phase entry,glucose depletion, oleate and alcohol;regulated by the HOG and Ras-Pka pathways 0.00010.0015 S000004297UBC12YLR306WverifiedEnzyme that mediates the conjugation of Rub1p, a ubiquitin-likeprotein, to other proteins; related to E2ubiquitin-conjugating enzymes 0.00010.0015 S000005999ATP4YPL078CverifiedSubunit b of the stator stalk of mitochondrial F1F0 ATPsynthase, which is a large, evolutionarilyconserved enzyme complex required for ATPsynthesis 0.00010.0015 S000001045YHR003CVerifiedProtein of unknown function, localized to the mitochondrial outer membrane 0.00010.0015 S000005731FMP38YOR205CuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.00010.0015 S000004183UPS1YLR193CverifiedMitochondrial intermembrane space protein that regulatesalternative processing and sorting of Mgm1p andother proteins; required for normalmitochondrial morphology; ortholog of humanPRELI 0.00010.0015 S000004758IMP1YMR150CverifiedCatalytic subunit of the mitochondrial inner membrane peptidasecomplex, required for maturation ofmitochondrial proteins of the intermembranespace; complex contains Imp1p and Imp2p (bothcatalytic subunits), and Som1p 0.00010.0015 S000004370SEC61YLR378CverifiedEssential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p);forms a channel for SRP-dependent proteinimport and retrograde transport of misfoldedproteins out of the ER; with Sec63 complexallows SRP-independent protein import into ER 0.00010.0015 S000001954MEI4YER044C-AverifiedMeiosis-specific protein involved in recombination; requiredfor chromosome synapsis; required forproduction of viable spores 0.00010.0015 S000001102VMA22YHR060WverifiedIntegral membrane protein that is required for vacuolarH+-ATPase (V-ATPase) function, although not anactual component of the V-ATPase complex;functions in the assembly of the V-ATPase;localized to the yeast endoplasmic reticulum(ER) 0.00010.0015 S000001117PPE1YHR075CverifiedProtein with carboxyl methyl esterase activity that may have arole in demethylation of the phosphoproteinphosphatase catalytic subunit; also identifiedas a small subunit mitochondrial ribosomalprotein 0.00010.0015 S000005620ARF3YOR094WverifiedGlucose-repressible ADP-ribosylation factor, GTPase of the Rassuperfamily involved in development of polarity 0.00010.0015 S000028718YOR394C-AUncharacterizedIdentified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 0.00010.0015 S000000146SEC17YBL050WverifiedPeripheral membrane protein required for vesicular transportbetween ER and Golgi and for the 'priming' stepin homotypic vacuole fusion, part of thecis-SNARE complex; has similarity to alpha-SNAP 0.00010.0015 S000006012GLR1YPL091WverifiedCytosolic and mitochondrial glutathione oxidoreductase,converts oxidized glutathione to reducedglutathione 0.00010.0015 S000028804YJL047C-AUncharacterized 0.00010.0015 S000004211RSA3YLR221CverifiedProtein with a likely role in ribosomal maturation, requiredfor accumulation of wild-type levels of large(60S) ribosomal subunits; binds to the helicaseDbp6p in pre-60S ribosomal particles in thenucleolus 0.00010.0015 S000000533RNQ1YCL028Wverified[PIN(+)] prion, an infectious protein conformation that isgenerally an ordered protein aggregate 0.00010.0015 S000000235RPL4AYBR031WverifiedN-terminally acetylated protein component of the large (60S)ribosomal subunit, nearly identical to Rpl4Bpand has similarity to E. coli L4 and rat L4ribosomal proteins 0.00010.0015 S000004001LOT6YLR011WverifiedPutative NADPH-dependent FMN reductase with strong ferricyanidereductase activity in vitro; gene expressionincreases in cultures shifted to a lowertemperature 0.00010.0015 S000000185AVT5YBL089WverifiedPutative transporter, member of a family of seven S. cerevisiaegenes (AVT1-7) related to vesicularGABA-glycine transporters 0.00010.0015 S000004212UTP13YLR222CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.00010.0015 S000002327SFA1YDL168WverifiedBifunctional enzyme containing both alcohol dehydrogenase andglutathione-dependent formaldehydedehydrogenase activities, functions informaldehyde detoxification and formation oflong chain and complex alcohols, regulated byHog1p-Sko1p 0.00010.0015 S000002373PRR2YDL214CverifiedProtein kinase with a possible role in MAP kinase signaling inthe pheromone response pathway 0.00010.0015 S000005935YPL014WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus 0.00010.0015 S000003162HOS2YGL194CverifiedHistone deacetylase required for gene activation via specificdeacetylation of lysines in H3 and H4 histonetails; subunit of the Set3 complex, ameiotic-specific repressor of sporulationspecific genes that contains deacetylaseactivity 0.00010.0015 S000000341YBR137WUncharacterizedProtein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); YBR137W is not an essential gene 0.00010.0015 S000004660AAC1YMR056CverifiedMitochondrial inner membrane ADP/ATP translocator, exchangescytosolic ADP for mitochondrially synthesizedATP; Aac1p is a minor isoform while Pet9p isthe major ADP/ATP translocator 0.00010.0015 S000003863VPS25YJR102CverifiedComponent of the ESCRT-II complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome 0.00010.0015 S000004281YLR290CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR290C is not an essential gene 0.00010.0015 S000000151YBL055CUncharacterizedHypothetical protein 0.00010.0015 S000005355HXT17YNR072WverifiedHexose transporter, up-regulated in media containing raffinoseand galactose at pH 7.7 versus pH 4.7,repressed by high levels of glucose 0.00010.0015 S000000737GLC3YEL011WverifiedGlycogen branching enzyme, involved in glycogen accumulation;green fluorescent protein (GFP)-fusion proteinlocalizes to the cytoplasm in a punctatepattern 0.00010.0015 S000003023OLE1YGL055WverifiedFatty acid desaturase, required for monounsaturated fatty acidsynthesis and for normal distribution ofmitochondria 0.00010.0015 S000001953YFR057WUncharacterizedHypothetical protein 0.00010.0015 S000005380TAT2YOL020WverifiedHigh affinity tryptophan and tyrosine permease, overexpressionconfers FK506 resistance 0.00010.0015 S000006245TIF5YPR041WverifiedTranslation initiation factor eIF-5; N-terminal domainfunctions as a GTPase-activating protein tomediate hydrolysis of ribosome-bound GTP;C-terminal domain is the core of ribosomalpreinitiation complex formation 0.00010.0015 S000029654FLP1R0010WverifiedSite-specific recombinase encoded on the 2-micron plasmid,required for 2-micron plasmid propagation aspart of a plasmid amplification system thatcompensates for any copy number decreasescaused by missegregation events 0.00010.0015 S000005824MUM3YOR298WverifiedProtein of unknown function involved in the organization of theouter spore wall layers; has similarity to thetafazzins superfamily of acyltransferases 0.00010.0015 S000004734SAS2YMR127CverifiedHistone acetyltransferase (HAT) catalytic subunit of the SAScomplex (Sas2p-Sas4p-Sas5p), which acetylatesfree histones and nucleosomes and regulatestranscriptional silencing; member of theMYSTacetyltransferase family 0.00010.0015 S000006043TFB2YPL122CverifiedSubunit of TFIIH and nucleotide excision repair factor 3complexes, involved in transcriptioninitiation, required for nucleotide excisionrepair, similar to 52 kDa subunit of humanTFIIH 0.00010.0015 S000003285YGR053CUncharacterizedPutative protein of unknown function 0.00010.0015 S000007472HUG1YML058W-AverifiedProtein involved in the Mec1p-mediated checkpoint pathway thatresponds to DNA damage or replication arrest,transcription is induced by DNA damage 0.00010.0015 S000006143FMP40YPL222WuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.00010.0015 S000002674YDR266CUncharacterizedHypothetical protein 0.00010.0015 S000005743RFC1YOR217WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon 0.00010.0015 S000004787SIP18YMR175WverifiedProtein of unknown function whose expression is induced byosmotic stress 0.00010.0015 S000005083RLR1YNL139CverifiedSubunit of the THO complex, which is required for efficienttranscription elongation and involved intranscriptional elongation-associatedrecombination; required for LacZ RNA expressionfrom certain plasmids 0.00010.0015 S000005460PKH2YOL100WverifiedSerine/threonine protein kinase involved insphingolipid-mediated signaling pathway thatcontrols endocytosis; activates Ypk1p andYkr2p, components of signaling cascade requiredfor maintenance of cell wall integrity;redundant with Pkh1p 0.00010.0015 S000002210SLC1YDL052Cverified1-acyl-sn-gylcerol-3-phosphate acyltransferase, catalyzes theacylation of lysophosphatidic acid to formphosphatidic acid, a key intermediate in lipidmetabolism; located in lipid particles andendoplasmic reticulum 0.00010.0015 S000002245LUC7YDL087CverifiedEssential protein associated with the U1 snRNP complex;splicing factor involved in recognition of 5'splice site 0.00010.00149&radic S000003634SAP185YJL098WverifiedProtein that forms a complex with the Sit4p protein phosphataseand is required for its function; member of afamily of similar proteins including Sap4p,Sap155p, and Sap190p 0.00010.00149 S000004375SMC6YLR383WverifiedProtein involved in structural maintenance of chromosomes;essential subunit of Mms21-Smc5-Smc6 complex;required for growth, DNA repair,interchromosomal and sister chromatidrecombination; homologous to S. pombe rad18 0.00010.00149 S000000941YER139CUncharacterizedHypothetical protein 0.00010.00149 S000001684MNN4YKL201CverifiedPutative positive regulator of mannosylphosphate transferase(Mnn6p), involved in mannosylphosphorylation ofN-linked oligosaccharides; expression increasesin late-logarithmic and stationary growthphases 0.00010.00149 S000000098HTB2YBL002WverifiedOne of two nearly identical (see HTB1) histone H2B subtypesrequired for chromatin assembly and chromosomefunction; Rad6p-Bre1p-Lge1p mediatedubiquitination regulates transcriptionalactivation, meiotic DSB formation and H3methylation 0.00010.00149 S000006405ARR3YPR201WverifiedArsenite transporter of the plasma membrane, required forresistance to arsenic compounds; transcriptionis activated by Arr1p in the presence ofarsenite 0.00010.00149 S000004228FAR10YLR238WverifiedProtein involved in G1 cell cycle arrest in response topheromone, in a pathway different from theFar1p-dependent pathway; interacts with Far3p,Far7p, Far8p, Far9p, and Far11p; potentialCdc28p substrate 0.00010.00149 S000000829GAL83YER027CverifiedOne of three possible beta-subunits of the Snf1 kinase complex,allows nuclear localization of the Snf1 kinasecomplex in the presence of a nonfermentablecarbon source; contains glycogen-binding domain 0.00010.00149 S000003288RSC1YGR056WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; containstwo essential bromodomains, a bromo-adjacenthomology (BAH) domain, and an AT hook 0.00010.00149 S000001370YIL108WUncharacterizedPutative metalloprotease 0.00010.00149 S000000763RAD23YEL037CverifiedProtein with ubiquitin-like N terminus, recognizes and bindsdamaged DNA (with Rad4p) during nucleotideexcision repair; regulates Rad4p levels,subunit of Nuclear Excision Repair Factor 2(NEF2); homolog of human HR23A and HR23Bproteins 0.00010.00149 S000028526YOR020W-AUncharacterizedIdentified by homology to Ashbya gossypii 0.00010.00149 S000000184TEL1YBL088CverifiedProtein kinase primarily involved in telomere lengthregulation; contributes to cell cyclecheckpoint control in response to DNA damage;functionally redundant with Mec1p; homolog ofhuman ataxia telangiectasia (ATM) gene 0.00010.00149 S000004678YMR074CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR074C is not an essential gene 0.00010.00149 S000000363IFA38YBR159WverifiedMicrosomal beta-keto-reductase; contains oleate responseelement (ORE) sequence in the promoter region;mutants exhibit reduced VLCFA synthesis,accumulate high levels of dihydrosphingosine,phytosphingosine and medium-chain ceramides. 0.00010.00149 S000000482DPB3YBR278WverifiedThird-largest subunit of DNA polymerase II (DNA polymeraseepsilon), required to maintain fidelity ofchromosomal replication and also forinheritance of telomeric silencing; mRNAabundance peaks at the G1/S boundary of thecell cycle 0.00010.00149 S000001686TOR2YKL203CverifiedPIK-related protein kinase and rapamycin target; subunit ofTORC1, a complex that regulates growth inresponse to nutrients and TORC2, a complex thatregulates cell-cycle dependent polarization ofthe actin cytoskeleton; involved in meiosis 0.00010.00149 S000004850BCH1YMR237WverifiedMember of the Chs5p-Arf1p-binding proteins (ChAPs), a group of4 related, interacting proteins (Bch1p, Fmp50p,Bud7p, Chs6p) that mediate export of specificcargo proteins, including chitin synthaseChs3p; may interact with ribosomes 0.00010.00149 S000007496IGO2YHR132W-AuncharacterizedPutative protein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to the cytoplasmand nucleus 0.00010.00149 S000003104MRM2YGL136CverifiedMitochondrial 21S rRNA methyltransferase, required formethylation of U(2791) in 21S rRNA; MRM2deletion confers thermosensitive respirationand loss of mitochondrial DNA; has similarityto Spb1p and Trm7p, and to E. coli FtsJ/RrmJ 0.00010.00149 S000005026PMS1YNL082WverifiedATP-binding protein required for mismatch repair in mitosis andmeiosis; functions as a heterodimer with Mlh1p,binds double- and single-stranded DNA via itsN-terminal domain, similar to E. coli MutL 0.00010.00149 S000003051SCY1YGL083WverifiedPutative kinase, suppressor of GTPase mutant, similar to bovinerhodopsin kinase 0.00010.00149 S000005144YNL200CUncharacterizedHypothetical protein; similarity to human TGR-CL10C, thyroidal receptor for N-acetylglucosamine 0.00010.00149 S000005316ABZ1YNR033WverifiedPara-aminobenzoate (PABA) synthase, has similarity toEscherichia coli PABA synthase components PabAand PabB 0.00010.00149 S000006439HTL1YCR020W-BverifiedSubunit of the RSC chromatin remodeling complex, a multisubunitcomplex that functions in transcriptionalregulation, chromosome stability andestablishing sister chromatid cohesion;involved in telomere maintenance 0.00010.00149 S000005918HSP33YOR391CuncharacterizedPossible chaperone and cysteine protease with similarity to E.coli Hsp31 and S. cerevisiae Hsp32p, Hsp33p,and Sno4p; member of the DJ-1/ThiJ/PfpIsuperfamily, which includes human DJ-1 involvedin Parkinson's disease 0.00010.00149 S000005181YTP1YNL237WverifiedProbable type-III integral membrane protein of unknownfunction, has regions of similarity tomitochondrial electron transport proteins 0.00010.00149 S000000008MDM10YAL010CverifiedSubunit of the mitochondrial sorting and assembly machinery(SAM complex); has a role in assembly of theTOM complex, which mediates protein importthrough the outer membrane; required for normalmitochondrial morphology and inheritance 0.00010.00149 S000028808YLR264C-AUncharacterizedPutative protein of unknown function 0.00010.00149 S000004528RPS1BYML063WverifiedRibosomal protein 10 (rp10) of the small (40S) subunit; nearlyidentical to Rps1Ap and has similarity to ratS3a ribosomal protein 0.00010.00149 S000003325YGR093WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus 0.00010.00149 S000002494RRP1YDR087CverifiedEssential evolutionarily conserved nucleolar protein necessaryfor biogenesis of 60S ribosomal subunits andprocessing of pre-rRNAs to mature rRNAs,associated with several distinct 66Spre-ribosomal particles 0.00010.00149 S000004531SMA2YML066CverifiedProtein of unknown function involved in the assembly of theprospore membrane during sporulation 0.00010.00149 S000004108YLR118CVerifiedAcyl-protein thioesterase responsible for depalmitoylation of Gpa1p; the mutant has no gross defects in signaling through the mating pathway; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 0.00010.00149 S000004517YML053CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YML053C is not an essential gene 0.00010.00149 S000006140PCL8YPL219WverifiedCyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) tophosphorylate and regulate glycogen synthase,also activates Pho85p for Glc8p phosphorylation 0.00010.00149 S000005735NPT1YOR209CverifiedNicotinate phosphoribosyltransferase, acts in the salvagepathway of NAD+ biosynthesis; required forsilencing at rDNA and telomeres and has a rolein silencing at mating-type loci; localized tothe nucleus 0.00010.00149 S000001052RPL27AYHR010WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl27Bp and has similarity to ratL27 ribosomal protein 0.00010.00149 S000000930YER128WUncharacterizedHypothetical protein 0.00010.00149 S000004057PET309YLR067CverifiedSpecific translational activator for the COX1 mRNA, alsoinfluences stability of intron-containing COX1primary transcripts; located in themitochondrial inner membrane 0.00010.00149 S000005004ARP5YNL059CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes 0.00010.00149 S000003473YAP1802YGR241CverifiedProtein involved in clathrin cage assembly; binds Pan1p andclathrin; homologous to Yap1801p, member of theAP180 protein family 0.00010.00149 S000004983GPI15YNL038WverifiedProtein involved in the synthesis of N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI), the firstintermediate in the synthesis ofglycosylphosphatidylinositol (GPI) anchors;homologous to the human PIG-H protein 0.00010.00149 S000005851FRT1YOR324CverifiedTail-anchored endoplasmic reticulum membrane protein that is asubstrate of the phosphatase calcineurin,interacts with homolog Frt2p, promotes cellgrowth in conditions of high Na+, alkaline pH,and cell wall stress 0.00010.00149 S000000880YER078CUncharacterizedMetallopeptidase, localized to the mitochondrial matrix 0.00010.00149 S000005467YOL107WUncharacterizedHypothetical protein 0.00010.00149 S000004535DAK1YML070WverifiedDihydroxyacetone kinase, required for detoxification ofdihydroxyacetone (DHA); involved in stressadaptation 0.00010.00148 S000000273TAT1YBR069CverifiedAmino acid transport protein for valine, leucine, isoleucine,and tyrosine, low-affinity tryptophan andhistidine transporter; overexpression confersFK506 resistance 0.00010.00148 S000006100PPQ1YPL179WverifiedPutative protein serine/threonine phosphatase; null mutationenhances efficiency of translationalsuppressors 0.00010.00148 S000003979YLL056CUncharacterizedPutative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene 0.00010.00148 S000002339YDL180WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole 0.00010.00148 S000006188ACM1YPL267WverifiedCell cycle regulated protein of unknown function; associatedwith Cdh1p and may supress theAPC/C[Cdh1]-mediated proteolysis of mitoticcyclins 0.00010.00148 S000005755WTM2YOR229WverifiedTranscriptional repressor involved in regulation of meiosis andsilencing; contains WD repeats 0.00010.00148 S000003892MNS1YJR131WverifiedAlpha-1,2-mannosidase involved in ER quality control; catalyzesthe removal of one mannose residue fromMan9GlcNAc to produce a single isomer ofMan8GlcNAc in N-linked oligosaccharidebiosynthesis; integral to ER membrane 0.00010.00148 S000003780TES1YJR019CverifiedPeroxisomal acyl-CoA thioesterase likely to be involved infatty acid oxidation rather than fatty acidsynthesis; conserved protein also found inhuman peroxisomes; TES1 mRNA levels increaseduring growth on fatty acids 0.00010.00148 S000003028YBP2YGL060WverifiedProtein with a role in resistance to oxidative stress; hassimilarity to Ybp1p, which is involved inregulation of the transcription factor Yap1pvia oxidation of specific cysteine residues 0.00010.00148 S000003590TIM54YJL054WverifiedComponent of the mitochondrial Tim54p-Tim22p complex involvedin insertion of polytopic proteins into theinner membrane 0.00010.00148 S000007232STF1YDL130W-AverifiedProtein involved in regulation of the mitochondrial F1F0-ATPsynthase; Stf1p and Stf2p act as stabilizingfactors that enhance inhibitory action of theInh1p protein 0.00010.00148 S000000555APA1YCL050CverifiedDiadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4Aphosphorylase), involved in catabolism ofbis(5'-nucleosidyl) tetraphosphates; hassimilarity to Apa2p 0.00010.00148 S000005447YOL087CUncharacterizedHypothetical protein 0.00010.00148 S000001588YKL105CUncharacterizedPutative protein of unknown function 0.00010.00148 S000003386GTO1YGR154CuncharacterizedOmega-class glutathione transferase; induced under oxidativestress; putative peroxisomal localization 0.00010.00148 S000004424IMD3YLR432WverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 0.00010.00148 S000002217RAD59YDL059CverifiedProtein involved in the repair of double-strand breaks in DNAduring vegetative growth via recombination andsingle-strand annealing; anneals complementarysingle-stranded DNA; homologous to Rad52p 0.00010.00148 S000005297YNR014WUncharacterizedHypothetical protein 0.00010.00148 S000000766UTR2YEL040WverifiedPutative glycosidase, glycosylphosphatidylinositol(GPI)-anchored protein localized to the budneck; has a role in cell wall maintenance 0.00010.00148 S000000329PTC4YBR125CverifiedCytoplasmic type 2C protein phosphatase; identified as ahigh-copy number suppressor of the syntheticlethality of a cnb1 mpk1 double deletion;overexpression decreases high-osmolarityinduced Hog1p phosphorylation and kinaseactivity 0.00010.00148 S000001116QNS1YHR074WverifiedGlutamine-dependent NAD(+) synthetase, essential for theformation of NAD(+) from nicotinic acid adeninedinucleotide 0.00010.00148 S000028725YPR159C-AUncharacterizedIdentified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 0.00010.00148 S000004907YMR293CUncharacterizedPutative protein similar to bacterial glutamyl-tRNA amidotransferases; may be involved in aerobic respiration; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR293C is not an essential gene 0.00010.00148 S000002621UPC2YDR213WverifiedSterol regulatory element binding protein, inducestranscription of sterol transport andbiosynthetic genes; involved in the anaerobicinduction of DAN/TIR mannoproteins andseripauperins; binucleate zinc cluster protein;Ecm22p homolog 0.00010.00148 S000000935GLC7YER133WverifiedCatalytic subunit of type 1 serine/threonine proteinphosphatase, involved in many processesincluding glycogen metabolism, sporulation, andmitosis; interacts with multiple regulatorysubunits; predominantly isolated with Sds22p 0.00010.00148 S000003989YLL066CUncharacterizedPutative protein of unknown function with similarity to helicases; YLL066C is not an essential gene 0.00010.00148 S000005568CUE5YOR042WuncharacterizedProtein containing a CUE domain that binds ubiquitin, which mayfacilitate intramolecular monoubiquitination;green fluorescent protein (GFP)-fusion proteinlocalizes to the cytoplasm in a punctatepattern 0.00010.00148 S000000883SER3YER081Wverified3-phosphoglycerate dehydrogenase, catalyzes the first step inserine and glycine biosynthesis; isozyme ofSer33p 0.00010.00148 S000004992SLM2YNL047CverifiedPhosphoinositide PI4,5P(2) binding protein, forms a complexwith Slm1p; acts downstream of Mss4p in apathway regulating actin cytoskeletonorganization in response to stress; subunit ofand phosphorylated by the TORC2 complex 0.00010.00148 S000006338MSS18YPR134WverifiedNuclear encoded protein needed for efficient splicing ofmitochondrial COX1 aI5beta intron; mss18mutations block cleavage of 5' exon - intronjunction; phenotype of intronless strainsuggests additional functions 0.00010.00148 S000002405SOR2YDL246CuncharacterizedProtein of unknown function, computational analysis oflarge-scale protein-protein interaction datasuggests a possible role in fructose or mannosemetabolism 0.00010.00148 S000004040YLR050CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene 0.00010.00148 S000003324DBF2YGR092WverifiedSer/Thr kinase involved in transcription and stress response;functions as part of a network of genes in exitfrom mitosis; localization is cell cycleregulated; activated by Cdc15p during the exitfrom mitosis 0.00010.00148 S000003246MSB2YGR014WverifiedMucin family member at the head of the Cdc42p- and MAPkinase-dependent filamentous growth signalingpathway; also functions as an osmosensor inparallel to the Sho1p-mediated pathway;potential Cdc28p substrate 0.00010.00148 S000003721YJL185CUncharacterizedPutative protein of unknown function; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene 0.00010.00148 S000001948RPN12YFR052WverifiedSubunit of the 19S regulatory particle of the 26S proteasomelid; synthetically lethal with RPT1, which isan ATPase component of the 19S regulatoryparticle; physically interacts with Nob1p andRpn3p 9e-050.00148 S000005028END3YNL084CverifiedEH domain-containing protein involved in endocytosis, actincytoskeletal organization and cell wallmorphogenesis; forms a complex with Sla1p andPan1p 9e-050.00148 S000003471PEX21YGR239CverifiedPart of a two-member peroxin family (Pex18p and Pex21p)specifically required for peroxisomal targetingof the Pex7p peroxisomal signal recognitionfactor and PTS2-type peroxisomal matrixproteins 9e-050.00148 S000005254ZIM17YNL310CverifiedHeat shock protein with a zinc finger motif; essential forprotein import into mitochondria; may act withPam18p to facilitate recognition and folding ofimported proteins by Ssc1p (mtHSP70) in themitochondrial matrix 9e-050.00148 S000004583VAN1YML115CverifiedComponent of the mannan polymerase I; forms a complex withMnn9p, which is involved in in mannansynthesis; mutants are vanadate-resistant 9e-050.00148 S000004558UTP14YML093WverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 9e-050.00148 S000003299YGR067CUncharacterizedPutative protein of unknown function; contains a zinc finger motif similar to that of Adr1p 9e-050.00148 S000005544ROD1YOR018WverifiedMembrane protein; overexpression confers resistance to the GSTsubstrate o-dinitrobenzene as well as to zincand calcium; contains 2 PY motifs, which arerequired for Rod1p interaction with Rsp5p, ahect-type ubiquitin ligase 9e-050.00148 S000006306RPL11AYPR102CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl11Bp; involved in ribosomalassembly; depletion causes degradation ofproteins and RNA of the 60S subunit; hassimilarity to E. coli L5 and rat L11 9e-050.00148 S000000187MAP2YBL091CverifiedMethionine aminopeptidase, catalyzes the cotranslationalremoval of N-terminal methionine from nascentpolypeptides; function is partially redundantwith that of Map1p 9e-050.00148 S000002806UTP5YDR398WverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 9e-050.00148 S000003374BTN2YGR142Wverifiedv-SNARE binding protein that facilitates specific proteinretrieval from a late endosome to the Golgi;modulates arginine uptake, possible role inmediating pH homeostasis between the vacuoleand plasma membrane H(+)-ATPase 9e-050.00148 S000004178MDL1YLR188WverifiedHalf-type ATP-binding cassette (ABC) transporter of the innermitochondrial membrane, mediates export ofpeptides generated upon proteolysis ofmitochondrial proteins, plays a role in theregulation of cellular resistance to oxidativestress 9e-050.00148 S000005648PFY1YOR122CverifiedProfilin, actin- and phosphatidylinositol4,5-bisphosphate-binding protein, plays a rolein cytoskeleton organization, required fornormal timing of actin polymerization inresponse to thermal stress; localizes to plasmamembrane and cytosol 9e-050.00148 S000001003PRS3YHL011Cverified5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involvedin nucleotide, histidine, and tryptophanbiosynthesis; one of a five related enzymes,which are active as heteromultimeric complexes 9e-050.00148 S000005786GCD1YOR260WverifiedGamma subunit of the translation initiation factor eIF2B, theguanine-nucleotide exchange factor for eIF2;activity subsequently regulated byphosphorylated eIF2; first identified as anegative regulator of GCN4 expression 9e-050.00148 S000000040ERV46YAL042WverifiedProtein localized to COPII-coated vesicles, forms a complexwith Erv41p; involved in the membrane fusionstage of transport 9e-050.00148 S000004076SMC4YLR086WverifiedSubunit of the condensin complex, which reorganizes chromosomesduring cell division, forms a stable complexwith Smc2p that has ATP-hydrolyzing andDNA-binding activity and promotes knotting ofcircular DNA; potential Cdc28p substrate 9e-050.00148 S000006283MRL1YPR079WverifiedMembrane protein with similarity to mammalianmannose-6-phosphate receptors, possiblyfunctions as a sorting receptor in the deliveryof vacuolar hydrolases 9e-050.00148 S000000305FES1YBR101CverifiedHsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog ofSil1p, which is the nucleotide exchange factorfor BiP (Kar2p) in the endoplasmic reticulum 9e-050.00148 S000000545GLK1YCL040WverifiedGlucokinase, catalyzes the phosphorylation of glucose at C6 inthe first irreversible step of glucosemetabolism; one of three glucosephosphorylating enzymes; expression regulatedby non-fermentable carbon sources 9e-050.00148 S000001136HXT1YHR094CverifiedLow-affinity glucose transporter of the major facilitatorsuperfamily, expression is induced by Hxk2p inthe presence of glucose and repressed by Rgt1pwhen glucose is limiting 9e-050.00148 S000029675REP1R0020CverifiedMaster regulator that acts in concert with Rep2p to regulatetranscript levels of the FLP1 gene thatpromotes plasmid copy amplification;autoregulates levels of its own transcript 9e-050.00148 S000004465GIS4YML006CverifiedCAAX box containing protein of unknown function, proposed to beinvolved in the RAS/cAMP signaling pathway 9e-050.00148 S000005342MNT4YNR059WverifiedPutative alpha-1,3-mannosyltransferase, not required forprotein O-glycosylation 9e-050.00148 S000001509GPX1YKL026CverifiedPhospholipid hydroperoxide glutathione peroxidase induced byglucose starvation that protects cells fromphospholipid hydroperoxides and nonphospholipidperoxides during oxidative stress 9e-050.00148 S000002353SNF3YDL194WverifiedPlasma membrane glucose sensor that regulates glucosetransport; has 12 predicted transmembranesegments; long cytoplasmic C-terminal tail isrequired for low glucose induction of hexosetransporter genes HXT2 and HXT4 9e-050.00148 S000006119RPL7BYPL198WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl7Ap and has similarity to E.coli L30 and rat L7 ribosomal proteins;contains a conserved C-terminal Nucleic acidBinding Domain (NDB2) 9e-050.00148 S000005636TFC7YOR110WverifiedOne of six subunits of the RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part of theTauA globular domain of TFIIIC that binds DNAat the BoxA promoter sites of tRNA and similargenes 9e-050.00148 S000000959COG3YER157WverifiedEssential component of the conserved oligomeric Golgi complex(Cog1p through Cog8p), a cytosolic tetheringcomplex that functions in protein traffickingto mediate fusion of transport vesicles toGolgi compartments 9e-050.00148 S000002361MRPL11YDL202WverifiedMitochondrial ribosomal protein of the large subunit 9e-050.00148 S000006048HHO1YPL127CverifiedHistone H1, a linker histone required for nucleosome packagingat restricted sites; suppresses DNA repairinvolving homologous recombination; notrequired for telomeric silencing, basaltranscriptional repression, or efficientsporulation 9e-050.00148 S000004248GSY2YLR258WverifiedGlycogen synthase, similar to Gsy1p; expression induced byglucose limitation, nitrogen starvation, heatshock, and stationary phase; activity regulatedby cAMP-dependent, Snf1p and Pho85p kinases aswell as by the Gac1p-Glc7p phosphatase 9e-050.00148 S000001870EPL1YFL024CverifiedComponent of NuA4, which is an essential histone H4/H2Aacetyltransferase complex; homologous toDrosophila Enhancer of Polycomb 9e-050.00148 S000003680YJL144WUncharacterizedCytoplasmic hydrophilin of unknown function, proposed to be involved in the dessication response; expression induced by osmotic stress, starvation conditions and during stationary phase; YJL144W is a non-essential gene 9e-050.00148 S000003862RSM26YJR101WverifiedMitochondrial ribosomal protein of the small subunit 9e-050.00148 S000002650AMD2YDR242WverifiedPutative amidase 9e-050.00148 S000003340CLB1YGR108WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the transition from G2 to Mphase; accumulates during G2 and M, thentargeted via a destruction box motif forubiquitin-mediated degradation by theproteasome 9e-050.00148 S000000931SAK1YER129WverifiedUpstream kinase for the SNF1 complex; partially redundantfunction with Elm1p and Tos3p; members of thisfamily of kinases have functional orthologywith LKB1, a mammalian kinase associated withPeutz-Jeghers cancer-susceptibility syndrome 9e-050.00148 S000000972ADK2YER170WverifiedMitochondrial adenylate kinase, catalyzes the reversiblesynthesis of GTP and AMP from GDP and ADP; mayserve as a back-up for synthesizing GTP or ADPdepending on metabolic conditions; 3' sequenceof ADK2 varies with strain background 9e-050.00148 S000001576MBR1YKL093WverifiedProtein involved in mitochondrial functions and stressresponse; overexpression suppresses growthdefects of hap2, hap3, and hap4 mutants 9e-050.00148 S000004727ADE17YMR120CverifiedEnzyme of 'de novo' purine biosynthesis containing both5-aminoimidazole-4-carboxamide ribonucleotidetransformylase and inosine monophosphatecyclohydrolase activities, isozyme of Ade16p;ade16 ade17 mutants require adenine andhistidine 9e-050.00148 S000003893NMD5YJR132WverifiedKaryopherin, a carrier protein involved in nuclear import ofproteins; importin beta homolog 9e-050.00148 S000001849SEC53YFL045CverifiedPhosphomannomutase, involved in synthesis of GDP-mannose anddolichol-phosphate-mannose; required forfolding and glycosylation of secretory proteinsin the ER lumen 9e-050.00148 S000006435DID2YKR035W-AverifiedClass E protein of the vacuolar protein-sorting (Vps) pathway,associates reversibly with the late endosome,has human ortholog that may be altered inbreast tumors 9e-050.00146 S000006139SAR1YPL218WverifiedGTPase, GTP-binding protein of the ARF family, component ofCOPII coat of vesicles; required for transportvesicle formation during ER to Golgi proteintransport 9e-050.00146 S000003527COS6YGR295CverifiedProtein of unknown function, member of the DUP380 subfamily ofconserved, often subtelomerically-encodedproteins 9e-050.00146 S000000507RER1YCL001WverifiedProtein involved in retention of membrane proteins, includingSec12p, in the ER; localized to Golgi;functions as a retrieval receptor in returningmembrane proteins to the ER 9e-050.00146 S000005401NOP12YOL041CverifiedNucleolar protein, required for pre-25S rRNA processing;contains an RNA recognition motif (RRM) and hassimilarity to Nop13p, Nsr1p, and putativeorthologs in Drosophila and S. pombe 9e-050.00146 S000007615YKL018C-AUncharacterizedPutative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 9e-050.00146 S000006002RPS9AYPL081WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps9Bp and has similarity to E.coli S4 and rat S9 ribosomal proteins 9e-050.00146 S000006019MGR2YPL098CuncharacterizedProtein required for growth of cells lacking the mitochondrialgenome 9e-050.00146 S000002357GGC1YDL198CverifiedMitochondrial GTP/GDP transporter, essential for mitochondrialgenome maintenance; has a role in mitochondrialiron transport; member of the mitochondrialcarrier family 9e-050.00146 S000003813RAD7YJR052WverifiedProtein that recognizes and binds damaged DNA in anATP-dependent manner (with Rad16p) duringnucleotide excision repair; subunit ofNucleotide Excision Repair Factor 4 (NEF4) 9e-050.00146 S000000860PET117YER058WverifiedProtein required for assembly of cytochrome c oxidase 9e-050.00146 S000001183RPL42BYHR141CverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl42Ap and has similarity to ratL44; required for propagation of the killertoxin-encoding M1 double-stranded RNA satelliteof the L-A double-stranded RNA virus 9e-050.00146 S000003053YGL085WUncharacterizedPutative protein of unknown function, has homology to Staphylococcus aureus nuclease; green fluorescent protein (GFP)-fusion protein localizes to mitochondria 9e-050.00146 S000003388PTI1YGR156WverifiedPta1p Interacting protein 9e-050.00146&radic S000002161MCD1YDL003WverifiedEssential protein required for sister chromatid cohesion inmitosis and meiosis; subunit of the cohesincomplex; expression is cell cycle regulated andpeaks in S phase 9e-050.00146 S000002631CRF1YDR223WverifiedTranscriptional corepressor involved in the regulation ofribosomal protein gene transcription via theTOR signaling pathway and protein kinase A,phosphorylated by activated Yak1p whichpromotes accumulation of Crf1p in the nucleus 9e-050.00146 S000000071KIN3YAR018CverifiedNonessential protein kinase with unknown cellular role 9e-050.00146 S000003581YJL045WUncharacterizedMinor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner 9e-050.00146 S000005660BAG7YOR134WverifiedRho GTPase activating protein (RhoGAP), stimulates theintrinsic GTPase activity of Rho1p, which playsa role in actin cytoskeleton organization andcontrol of cell wall synthesis; structurallyand functionally related to Sac7p 9e-050.00146 S000006214RPA135YPR010CverifiedRNA polymerase I subunit A135 9e-050.00146 S000003193VRG4YGL225WverifiedGolgi GDP-mannose transporter; regulates Golgi function andglycosylation in Golgi 9e-050.00146 S000005449HAL9YOL089CverifiedPutative transcription factor containing a zinc finger;overexpression increases salt tolerance throughincreased expression of the ENA1 (Na+/Li+extrusion pump) gene while gene disruptiondecreases both salt tolerance and ENA1expression 9e-050.00146 S000001246RPS4BYHR203CverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps4Ap and has similarity to ratS4 ribosomal protein 9e-050.00146 S000004969YNL024CUncharacterizedPutative protein of unknown function with seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL024C is not an essential gene 9e-050.00146 S000005183LAP3YNL239WverifiedAminopeptidase of cysteine protease family, has a DNA bindingactivity and acts as bleomycin hydrolase invitro; transcription is regulated by galactosevia Gal4p 9e-050.00146 S000002448RSM10YDR041WverifiedMitochondrial ribosomal protein of the small subunit, hassimilarity to E. coli S10 ribosomal protein;essential for viability, unlike most othermitoribosomal proteins 9e-050.00146 S000002639COX20YDR231CverifiedMitochondrial inner membrane protein, required for proteolyticprocessing of Cox2p and its assembly intocytochrome c oxidase 9e-050.00146 S000028828YHL015W-AUncharacterizedPutative protein of unknown function 9e-050.00146 S000006075PEP4YPL154CverifiedVacuolar aspartyl protease (proteinase A), required for theposttranslational precursor maturation ofvacuolar proteinases; synthesized as a zymogen,self-activates 9e-050.00146 S000001829YFL065CUncharacterizedPutative protein of unknown function 9e-050.00146 S000002256SNU23YDL098CverifiedComponent of U4/U6.U5 snRNP involved in mRNA splicing viaspliceosome 9e-050.00146&radic S000005732NOC2YOR206WverifiedProtein that forms a nucleolar complex with Mak21p that bindsto 90S and 66S pre-ribosomes, as well as anuclear complex with Noc3p that binds to 66Spre-ribosomes; both complexes mediateintranuclear transport of ribosomal precursors 9e-050.00146 S000004546YML081WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YML081w is not an essential gene 9e-050.00146 S000003871YMR1YJR110WverifiedPhosphatidylinositol 3-phosphate [PI(3)P] phosphatase,regulates the localization and levels ofPI(3)P; involved in cytoplasm to vacuole (CVT)transport; has similarity to the conservedmyotubularin dual specificity phosphatasefamily 9e-050.00146 S000002925GRH1YDR517WuncharacterizedProtein involved in the spindle assembly checkpoint; homolog ofhuman GRASP65, which is a Golgi localizedprotein that functions in postmitoticreassembly of Golgi stacks 9e-050.00146 S000004621STB4YMR019WverifiedProtein that binds Sin3p in a two-hybrid assay; contains aZn(II)2Cys6 zinc finger domain characteristicof DNA-binding proteins 9e-050.00146 S000003698JJJ2YJL162CuncharacterizedProtein of unknown function, contains a J-domain, which is aregion with homology to the E. coli DnaJprotein 9e-050.00146 S000003210KAP114YGL241WverifiedKaryopherin, responsible for nuclear import of Spt15p, histonesH2A and H2B, and Nap1p; amino terminus showssimilarity to those of other importins,particularly Cse1p; localization is primarilynuclear 9e-050.00146 S000001129YHR087WVerifiedProtein involved in RNA metabolism, one of two yeast homologs (with Sdo1p/Ylr022cp) of the human protein SBDS responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome, also conserved in Archaea 9e-050.00146 S000005508SPT20YOL148CverifiedSubunit of the SAGA transcriptional regulatory complex,involved in maintaining the integrity of thecomplex 9e-050.00146 S000000445YBR241CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene 9e-050.00146 S000028437SLO1YER180C-AverifiedProtein interacting with Arl3p, which is a GTPase of the Rassuperfamily involved in vesicle-tethering atthe Golgi; putative ortholog of human SCOCO 9e-050.00146 S000005415PSH1YOL054WuncharacterizedNuclear protein, putative RNA polymerase II elongation factor;isolated as Pob3p/Spt16p-binding protein 9e-050.00146 S000007591YBL029C-AUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica 9e-050.00146 S000003917THI11YJR156CverifiedProtein involved in synthesis of the thiamine precursorhydroxymethylpyrimidine (HMP); member of asubtelomeric gene family including THI5, THI11,THI12, and THI13 9e-050.00146 S000001461SEC11YIR022Wverified18kDa catalytic subunit of the Signal Peptidase Complex (SPC;Spc1p, Spc2p, Spc3p, and Sec11p) which cleavesthe signal sequence of proteins targeted to theendoplasmic reticulum 9e-050.00146 S000005895RAD17YOR368WverifiedCheckpoint protein, involved in the activation of the DNAdamage and meiotic pachytene checkpoints; withMec3p and Ddc1p, forms a clamp that is loadedonto partial duplex DNA; homolog of human andS. pombe Rad1 and U. maydis Rec1 proteins 9e-050.00146 S000000617YCR023CUncharacterizedPutative protein of unknown function; YCR023C is not an essential gene 9e-050.00146 S000003362YGR130CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7) 9e-050.00146 S000004570CAC2YML102WverifiedComponent of the chromatin assembly complex (with Rlf2p andMsi1p) that assembles newly synthesizedhistones onto recently replicated DNA, requiredfor building functional kinetochores, conservedfrom yeast to humans 9e-050.00146 S000003188YGL220WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus 9e-050.00146 S000003343YGR111WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 9e-050.00146 S000003177MIG2YGL209WverifiedProtein containing zinc fingers, involved in repression, alongwith Mig1p, of SUC2 (invertase) expression byhigh levels of glucose; binds to Mig1p-bindingsites in SUC2 promoter 9e-050.00146 S000002462PST1YDR055WverifiedCell wall protein that contains a putative GPI-attachment site;secreted by regenerating protoplasts;up-regulated by activation of the cellintegrity pathway, as mediated by Rlm1p;upregulated by cell wall damage via disruptionof FKS1 9e-050.00146 S000005586YOR060CUncharacterizedProtein required for cell viability 9e-050.00146 S000002947YDR539WUncharacterizedHypothetical protein 9e-050.00146 S000000948LSM5YER146WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 9e-050.00146&radic S000006407YPR203WUncharacterizedHypothetical protein 9e-050.00146 S000005622RPS7AYOR096WverifiedProtein component of the small (40S) ribosomal subunit, nearlyidentical to Rps7Bp; interacts with Kti11p;deletion causes hypersensitivity to zymocin;has similarity to rat S7 and Xenopus S8ribosomal proteins 9e-050.00146 S000002244YDL086WUncharacterizedPutative protein of unknown function; localizes to the mitochondrion; YDL086W is not an essential gene 9e-050.00146 S000005328PET494YNR045WverifiedSpecific translational activator for the COX3 mRNA that actstogether with Pet54p and Pet122p; located inthe mitochondrial inner membrane 9e-050.00146 S000006136CBP3YPL215WverifiedMitochondrial protein required for assembly of ubiquinolcytochrome-c reductase complex (cytochrome bc1complex); interacts with Cbp4p and function ispartially redundant with that of Cbp4p 9e-050.00146 S000002907LCD1YDR499WverifiedEssential protein required for the DNA integrity checkpointpathways; interacts physically with Mec1p;putative homolog of S. pombe Rad26 and humanATRIP 9e-050.00146 S000007348TIM8YJR135W-AverifiedMitochondrial intermembrane space protein mediating import andinsertion of polytopic inner membrane proteins;homolog of human DDP1 (deafness dystoniapeptide 1) which is mutated in the X-linkedMohr-Tranebjaerg syndrome 9e-050.00146 S000002487VPS41YDR080WverifiedVacuolar membrane protein that is a subunit of the homotypicvacuole fusion and vacuole protein sorting(HOPS) complex; essential for membrane dockingand fusion at the Golgi-to-endosome andendosome-to-vacuole stages of protein transport 9e-050.00146 S000004165CBF5YLR175WverifiedPseudouridine synthase catalytic subunit of box H/ACA smallnucleolar ribonucleoprotein particles(snoRNPs), acts on both large and small rRNAsand on snRNA U2 9e-050.00146 S000005551HST3YOR025WverifiedMember of the Sir2 family of NAD(+)-dependent proteindeacetylases; involved along with Hst4p intelomeric silencing, cell cycle progression,radiation resistance, genomic stability andshort-chain fatty acid metabolism 9e-050.00146 S000000835ZRG8YER033CverifiedProtein of unknown function; authentic, non-tagged protein isdetected in highly purified mitochondria inhigh-throughput studies; GFP-fusion protein islocalized to the cytoplasm; transcriptioninduced under conditions of zinc deficiency 9e-050.00146 S000001044LEU5YHR002WverifiedMitochondrial carrier protein involved in the accumulation ofCoA in the mitochondrial matrix; homolog ofhuman Graves disease protein; does not encodean isozyme of Leu4p, as first hypothesized 9e-050.00146 S000001068PPA1YHR026WverifiedSubunit c'' of the vacuolar ATPase, which functions inacidification of the vacuole; one of threeproteolipid subunits of the V0 domain 9e-050.00146 S000001440SGN1YIR001CverifiedCytoplasmic RNA-binding protein, contains an RNA recognitionmotif (RRM); may have a role in mRNAtranslation, as suggested by geneticinteractions with genes encoding proteinsinvolved in translational initiation 9e-050.00146 S000002533SWF1YDR126WverifiedPalmitoyltransferase that acts on the SNAREs Snc1p, Syn8p,Tlg1p and likely on all SNAREs; member of afamily of putative palmitoyltransferasescontaining an Asp-His-His-Cys-cysteine rich(DHHC-CRD) domain; may have a role in vacuolefusion 9e-050.00146 S000003823NTA1YJR062CverifiedAmidase, removes the amide group from N-terminal asparagine andglutamine residues to generate proteins withN-terminal aspartate and glutamate residuesthat are targets of ubiquitin-mediateddegradation 9e-050.00146 S000003264GSC2YGR032WverifiedCatalytic subunit of 1,3-beta-glucan synthase, involved information of the inner layer of the spore wall;activity positively regulated by Rho1p andnegatively by Smk1p; has similarity to analternate catalytic subunit, Fks1p (Gsc1p) 9e-050.00146 S000028584YOR316C-AUncharacterizedIdentified by fungal homology and RT-PCR 9e-050.00146 S000004481OST6YML019WverifiedSubunit of the oligosaccharyltransferase complex of the ERlumen, which catalyzes asparagine-linkedglycosylation of newly synthesized proteins;similar to and partially functionally redundantwith Ost3p 9e-050.00146 S000000827GCD11YER025WverifiedGamma subunit of the translation initiation factor eIF2,involved in the identification of the startcodon; binds GTP when forming the ternarycomplex with GTP and tRNAi-Met 9e-050.00146 S000003211YGL242CUncharacterizedPutative protein of unknown function; deletion mutant is viable 9e-050.00146 S000005791RBL2YOR265WverifiedProtein involved in microtubule morphogenesis, required forprotection from excess free beta-tubulin;proposed to be involved the folding ofbeta-tubulin 9e-050.00146 S000003005PNC1YGL037CverifiedNicotinamidase that converts nicotinamide to nicotinic acid aspart of the NAD(+) salvage pathway, requiredfor life span extension by calorie restriction;PNC1 expression responds to all known stimulithat extend replicative life span 9e-050.00146 S000000339CKS1YBR135WverifiedSubunit of the Cdc28 protein kinase, required for mitoticproteolysis, may also be involved in theproteolysis of the G1 cyclins 9e-050.00146 S000005042RAS2YNL098CverifiedGTP-binding protein that regulates the nitrogen starvationresponse, sporulation, and filamentous growth;farnesylation and palmitoylation required foractivity and localization to plasma membrane;homolog of mammalian Ras proto-oncogenes 9e-050.00146 S000003652NCA3YJL116CverifiedProtein that functions with Nca2p to regulate mitochondrialexpression of subunits 6 (Atp6p) and 8 (Atp8p )of the Fo-F1 ATP synthase; member of the SUNfamily 9e-050.00146 S000004054YLR064WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR064W is not an essential gene 9e-050.00146 S000003519YGR287CUncharacterizedPutative protein of unknown function; similarity to alpha-D-glucosidase (maltase); localizes to the mitochondrion 9e-050.00146 S000004121ACE2YLR131CverifiedTranscription factor that activates expression of earlyG1-specific genes, localizes to daughter cellnuclei after cytokinesis and delays G1progression in daughters, localization isregulated by phosphorylation; potential Cdc28psubstrate 9e-050.00146 S000004721FMP24YMR115WuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 9e-050.00146 S000004892YMR279CUncharacterizedPutative protein of unknown function; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene 9e-050.00146 S000002499UBC13YDR092WverifiedUbiquitin-conjugating enzyme involved in the error-free DNApostreplication repair pathway; interacts withMms2p to assemble ubiquitin chains at the UbLys-63 residue; DNA damage triggersredistribution from the cytoplasm to thenucleus 9e-050.00146 S000005016RNH201YNL072WverifiedRibonuclease H2 catalytic subunit, removes RNA primers duringOkazaki fragment synthesis; cooperates withRad27p nuclease 9e-050.00146 S000001143BIG1YHR101CverifiedIntegral membrane protein of the endoplasmic reticulum,required for normal content of cell wallbeta-1,6-glucan 9e-050.00146 S000003492TNA1YGR260WverifiedHigh affinity nicotinic acid plasma membrane permease,responsible for uptake of low levels ofnicotinic acid; expression of the geneincreases in the absence of extracellularnicotinic acid or para-aminobenzoate (PABA) 9e-050.00146 S000005977YPL056CUncharacterizedHypothetical protein 9e-050.00146 S000003653PHO86YJL117WverifiedEndoplasmic reticulum (ER) resident protein required for ERexit of the high-affinity phosphate transporterPho84p, specifically required for packaging ofPho84p into COPII vesicles 9e-050.00146 S000003733UBP12YJL197WverifiedUbiquitin-specific protease present in the nucleus andcytoplasm that cleaves ubiquitin fromubiquitinated proteins 9e-050.00146 S000006282YPR078CUncharacterizedHypothetical protein 9e-050.00146 S000005951YPL030WUncharacterizedHypothetical protein 9e-050.00146 S000003511SCW4YGR279CverifiedCell wall protein with similarity to glucanases; scw4 scw10double mutants exhibit defects in mating 9e-050.00146 S000001836THI5YFL058WverifiedProtein involved in synthesis of the thiamine precursorhydroxymethylpyrimidine (HMP); member of asubtelomeric gene family including THI5, THI11,THI12, and THI13 9e-050.00146 S000028848YMR175W-AUncharacterizedPutative protein of unknown function 9e-050.00146 S000003079NSA1YGL111WverifiedConstituent of 66S pre-ribosomal particles, involved in 60Sribosomal subunit biogenesis 9e-050.00146 S000003929MMM1YLL006WverifiedMitochondrial outer membrane protein required for normalmitochondrial morphology and mtDNA stability;involved in tethering mitochondria to the actincytoskeleton and in anchoring mtDNA nucleoids 9e-050.00146 S000002440MRH1YDR033WverifiedProtein that localizes primarily to the plasma membrane, alsofound at the nuclear envelope; has similarityto Hsp30p and Yro2p, which are induced duringheat shock 9e-050.00146 S000004976HHT2YNL031CverifiedOne of two identical histone H3 proteins (see also HHT1); corehistone required for chromatin assembly,involved in heterochromatin-mediated telomericand HM silencing; regulated by acetylation,methylation, and mitotic phosphorylation 9e-050.00146 S000003197SHE10YGL228WverifiedPutative glycosylphosphatidylinositol (GPI)-anchored protein ofunknown function; overexpression causes growtharrest 9e-050.00146 S000004367STP3YLR375WuncharacterizedZinc-finger protein of unknown function, possibly involved inpre-tRNA splicing and in uptake ofbranched-chain amino acids 9e-050.00146 S000005099YNL155WUncharacterizedHypothetical protein 9e-050.00146 S000002792ATO3YDR384CverifiedPlasma membrane protein, regulation pattern suggests a possiblerole in export of ammonia from the cell; memberof the TC 9.B.33 YaaH family of putativetransporters 9e-050.00146 S000003025YGL057CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria; null mutant exhibits a growth defect on a non-fermentable (respiratory) carbon source; YGL057C is not an essential gene 9e-050.00146 S000002776YPR1YDR368Wverified2-methylbutyraldehyde reductase, may be involved in isoleucinecatabolism 9e-050.00146 S000005259ATP11YNL315CverifiedMolecular chaperone, required for the assembly of alpha andbeta subunits into the F1 sector ofmitochondrial F1F0 ATP synthase 9e-050.00146 S000000879YER077CUncharacterizedHypothetical protein 9e-050.00146 S000004134ACF2YLR144CverifiedIntracellular beta-1,3-endoglucanase, expression is inducedduring sporulation; may have a role in corticalactin cytoskeleton assembly 9e-050.00146 S000000980PDA1YER178WverifiedE1 alpha subunit of the pyruvate dehydrogenase (PDH) complex,catalyzes the direct oxidative decarboxylationof pyruvate to acetyl-CoA, regulated by glucose 9e-050.00146 S000002273IWR1YDL115CuncharacterizedProtein of unknown function, deletion causes hypersensitivityto the K1 killer toxin 9e-050.00146 S000005222CAF120YNL278WverifiedPart of the evolutionarily-conserved CCR4-NOT transcriptionalregulatory complex involved in controlling mRNAinitiation, elongation, and degradation 9e-050.00146 S000002281SNA4YDL123WverifiedProtein of unknown function, localized to the vacuolar outermembrane 9e-050.00146 S000003256THG1YGR024CverifiedtRNAHis guanylyltransferase, adds a guanosine residue to the 5'end of tRNAHis after transcription and RNase Pcleavage; couples nuclear division andmigration to cell budding and cytokinesis;essential enzyme conserved among eukaryotes 9e-050.00146 S000000340MEC1YBR136WverifiedGenome integrity checkpoint protein and PI kinase superfamilymember; signal transducer required for cellcycle arrest and transcriptional responsesprompted by damaged or unreplicated DNA;monitors and participates in meioticrecombination 9e-050.00146 S000004221BNA5YLR231CverifiedKynureninase, required for biosynthesis of nicotinic acid fromtryptophan via kynurenine pathway 9e-050.00146 S000005794YOR268CUncharacterizedPutative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene 9e-050.00146 S000004924GAS1YMR307WverifiedBeta-1.3-glucanosyltransferase, required for cell wallassembly; localizes to the cell surface via aglycosylphosphatidylinositol (GPI) anchor 9e-050.00146 S000004668AEP1YMR064WverifiedProtein required for expression of the mitochondrial OLI1 geneencoding subunit 9 of F1-F0 ATP synthase 9e-050.00146 S000000946UBP5YER144CverifiedPutative ubiquitin-specific protease, closest paralog of Doa4pbut has no functional overlap; concentrates atthe bud neck 9e-050.00146 S000003582YJL046WUncharacterizedPutative protein of unknown function, predicted to encode a lipoate-protein ligase A family member; deletion mutant has a respiratory growth defect 9e-050.00146 S000000058GDH3YAL062WverifiedNADP(+)-dependent glutamate dehydrogenase, synthesizesglutamate from ammonia and alpha-ketoglutarate;rate of alpha-ketoglutarate utilization differsfrom Gdh1p; expression regulated by nitrogenand carbon sources 9e-050.00146 S000003144YGL176CUncharacterizedPutative protein of unknown function; deletion mutant is viable and has no detectable phenotype 9e-050.00146 S000001887BLM10YFL007WverifiedProteosome activator subunit; found in association with coreparticles, with and without the 19S regulatoryparticle; required for resistance to bleomycin,may be involved in protecting against oxidativedamage; similar to mammalian PA200 9e-050.00146 S000002324CDC36YDL165WverifiedComponent of the CCR4-NOT complex, which has multiple roles inregulating mRNA levels including regulation oftranscription and destabilizing mRNAs bydeadenylation; basal transcription factor 9e-050.00146 S000000315YSA1YBR111CverifiedNudix hydrolase family member with ADP-ribose pyrophosphataseactivity 9e-050.00146 S000000032MTW1YAL034W-AverifiedEssential component of the MIND kinetochore complex (Mtw1pIncluding Nnf1p-Nsl1p-Dsn1p) which joinskinetochore subunits contacting DNA to thosecontacting microtubules; critical tokinetochore assembly 9e-050.00146 S000000751YEL025CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 9e-050.00146 S000000882FMP29YER080WuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 9e-050.00146 S000004925PSE1YMR308CverifiedKaryopherin/importin that interacts with the nuclear porecomplex; acts as the nuclear import receptorfor specific proteins, including Pdr1p, Yap1p,Ste12p, and Aft1p 9e-050.00146 S000006061MKK2YPL140CverifiedMitogen-activated kinase kinase involved in protein kinase Csignaling pathway that controls cell integrity;upon activation by Bck1p phosphorylatesdownstream target, Slt2p; functionallyredundant with Mkk1p 9e-050.00146 S000004876SAP30YMR263WverifiedSubunit of a histone deacetylase complex, along with Rpd3p andSin3p, that is involved in silencing attelomeres, rDNA, and silent mating-type loci;involved in telomere maintenance 9e-050.00146 S000002862GUK1YDR454CverifiedGuanylate kinase, converts GMP to GDP; required for growth andmannose outer chain elongation of cell wallN-linked glycoproteins 9e-050.00146 S000003710KRE9YJL174WverifiedGlycoprotein involved in cell wall beta-glucan assembly; nullmutation leads to severe growth defects,aberrant multibudded morphology, and matingdefects 9e-050.00146 S000003549VTC4YJL012CverifiedVacuolar membrane protein involved in vacuolar polyphosphateaccumulation; functions as a regulator ofvacuolar H+-ATPase activity and vacuolartransporter chaperones; involved innon-autophagic vacuolar fusion 9e-050.00146 S000004160APS1YLR170CverifiedSmall subunit of the clathrin-associated adaptor complex AP-1,which is involved in protein sorting at thetrans-Golgi network; homolog of the sigmasubunit of the mammalian clathrin AP-1 complex 9e-050.00146 S000005209IST1YNL265CverifiedPutative translation initiation factor, as suggested bycomputational analysis of large-scaleprotein-protein interaction data 9e-050.00146 S000000390PCH2YBR186WverifiedNucleolar component of the pachytene checkpoint, which preventschromosome segregation when recombination andchromosome synapsis are defective; alsorepresses meiotic interhomolog recombination inthe rDNA 9e-050.00145 S000004140STM1YLR150WverifiedProtein that binds G4 quadruplex and purine motif triplexnucleic acid; acts with Cdc13p to maintaintelomere structure; interacts with ribosomesand subtelomeric Y' DNA; multicopy suppressorof tom1 and pop2 mutations 9e-050.00145 S000002279YDL121CUncharacterizedHypothetical protein 9e-050.00145 S000004804GYL1YMR192WverifiedPutative GTPase activating protein (GAP) that may have a rolein polarized exocytosis; stimulates Gyp5p GAPactivity on Ypt1p, colocalizes with Gyp5p atsites of polarized growth; interacts withGyp5p, Rvs161p, and Rvs167p 9e-050.00145 S000000434OM14YBR230CverifiedIntegral mitochondrial outer membrane protein; abundance isdecreased in cells grown in glucose relative toother carbon sources; appears to contain 3alpha-helical transmembrane segments; ORFencodes a 97-basepair intron 9e-050.00145 S000000033FUN12YAL035WverifiedGTPase, required for general translation initiation bypromoting Met-tRNAiMet binding to ribosomes andribosomal subunit joining; homolog of bacterialIF2 9e-050.00145 S000004955YNL010WUncharacterizedPutative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation 9e-050.00145 S000001391TAO3YIL129CverifiedProtein involved in cell morphogenesis and proliferation,associated with protein kinase Cbk1p; mutantsactivate OCH1 transcription 9e-050.00145 S000002393GYP7YDL234CverifiedGTPase-activating protein for yeast Rab family membersincluding: Ypt7p (most effective), Ypt1p,Ypt31p, and Ypt32p (in vitro); involved invesicle mediated protein trafficking 9e-050.00145 S000002900IZH1YDR492WverifiedMembrane protein involved in zinc metabolism, member of thefour-protein IZH family; transcription isregulated directly by Zap1p, expression inducedby zinc deficiency and fatty acids; deletionincreases sensitivity to elevated zinc 9e-050.00145 S000000472MRPL37YBR268WverifiedMitochondrial ribosomal protein of the large subunit 9e-050.00145&radic S000004382ECM19YLR390WverifiedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 9e-050.00145 S000001096YHR054CUncharacterizedPutative protein of unknown function 9e-050.00145 S000002228BDF2YDL070WverifiedProtein involved in transcription initiation at TATA-containingpromoters; associates with the basaltranscription factor TFIID; contains twobromodomains; corresponds to the C-terminalregion of mammalian TAF1; redundant with Bdf1p 9e-050.00145 S000000457SRB6YBR253WverifiedEssentital subunit of the RNA polymerase II mediator complex;associates with core polymerase subunits toform the RNA polymerase II holoenzyme;essential for transcriptional regulation 9e-050.00145 S000006370MRP2YPR166CverifiedMitochondrial ribosomal protein of the small subunit 9e-050.00145 S000003949HSP104YLL026WverifiedHeat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p(Hsp70) to refold and reactivate previouslydenatured, aggregated proteins; responsive tostresses including: heat, ethanol, and sodiumarsenite; involved in [PSI+] propagation 9e-050.00145 S000005843COT1YOR316CverifiedVacuolar transporter that mediates zinc transport into thevacuole; overexpression confers resistance tocobalt and rhodium 9e-050.00145 S000006329YLH47YPR125WuncharacterizedMitochondrial inner membrane protein exposed to themitochondrial matrix, associates withmitochondrial ribosomes, NOT required forrespiratory growth; homolog of human Letm1, aprotein implicated in Wolf-Hirschhorn syndrome 9e-050.00145 S000006353NCE102YPR149WverifiedProtein of unknown function; contains transmembrane domains;involved in secretion of proteins that lackclassical secretory signal sequences; componentof the detergent-insoluble glycolipid-enrichedcomplexes (DIGs) 9e-050.00145 S000000400PGI1YBR196CverifiedGlycolytic enzyme phosphoglucose isomerase, catalyzes theinterconversion of glucose-6-phosphate andfructose-6-phosphate; required for cell cycleprogression and completion of the gluconeogenicevents of sporulation 9e-050.00145 S000000603ADY2YCR010CverifiedAcetate transporter required for normal sporulation 9e-050.00145 S000000364CDC28YBR160WverifiedCatalytic subunit of the main cell cycle cyclin-dependentkinase (CDK); alternately associates with G1cyclins (CLNs) and G2/M cyclins (CLBs) whichdirect the CDK to specific substrates 9e-050.00145 S000002413SOK1YDR006CverifiedProtein whose overexpression suppresses the growth defect ofmutants lacking protein kinase A activity;involved in cAMP-mediated signaling; localizedto the nucleus; similar to the mousetestis-specific protein PBS13 9e-050.00145 S000002811DIT1YDR403WverifiedSporulation-specific enzyme required for spore wall maturation,involved in the production of a solubleLL-dityrosine-containing precursor of the sporewall; transcripts accumulate at the time ofprospore enclosure 9e-050.00145 S000004753NDE1YMR145CverifiedMitochondrial external NADH dehydrogenase, catalyzes theoxidation of cytosolic NADH; Nde1p and Nde2pare involved in providing the cytosolic NADH tothe mitochondrial respiratory chain 9e-050.00145 S000005820RRS1YOR294WverifiedEssential protein that binds ribosomal protein L11 and isrequired for nuclear export of the 60Spre-ribosomal subunit during ribosomebiogenesis; mouse homolog shows alteredexpression in Huntington's disease model mice 9e-050.00145 S000005450MSH2YOL090WverifiedProtein that forms heterodimers with Msh3p and Msh6p that bindto DNA mismatches to initiate the mismatchrepair process; contains a Walker ATP-bindingmotif required for repair activity; Msh2p-Msh6pbinds to and hydrolyzes ATP 9e-050.00145 S000004883RRN9YMR270CverifiedProtein involved in promoting high level transcription of rDNA,subunit of UAF (upstream activation factor) forRNA polymerase I 9e-050.00145 S000003443ZPR1YGR211WverifiedEssential protein with two zinc fingers, present in the nucleusof growing cells but relocates to the cytoplasmin starved cells via a process mediated byCpr1p; binds to translation elongation factoreEF-1 (Tef1p) 9e-050.00145 S000001271FAA3YIL009WverifiedLong chain fatty acyl-CoA synthetase, has a preference for C16and C18 fatty acids; green fluorescent protein(GFP)-fusion protein localizes to the cellperiphery 9e-050.00145 S000005431NBA1YOL070CverifiedProtein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to the cellperiphery, cytoplasm, and bud neck; potentialCdc28p substrate 9e-050.00145 S000004880PPA2YMR267WverifiedMitochondrial inorganic pyrophosphatase, required formitochondrial function and possibly involved inenergy generation from inorganic pyrophosphate 9e-050.00145 S000000832CHZ1YER030WuncharacterizedPutative chaperone for Htz1p/H2A-H2B dimer 9e-050.00145 S000003890YJR129CUncharacterizedPutative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 9e-050.00145 S000005041PHO23YNL097CverifiedProbable component of the Rpd3 histone deacetylase complex,involved in transcriptional regulation of PHO5;C-terminus has similarity to human candidatetumor suppressor p33(ING1) 9e-050.00145 S000028560YLL006W-AUncharacterizedPutative protein of unknown function; identified by fungal homology and RT-PCR 9e-050.00145 S000003234SWC4YGR002CverifiedProtein of unknown function, component of the Swr1p complexthat incorporates Htz1p into chromatin;component of the NuA4 histone acetyltransferasecomplex 9e-050.00145 S000004657STB2YMR053CverifiedProtein that interacts with Sin3p in a two-hybrid assay and ispart of a large protein complex with Sin3p andStb1p 9e-050.00145&radic S000006313YPR109WUncharacterizedHypothetical protein 9e-050.00145 S000001881IES1YFL013CverifiedSubunit of the INO80 chromatin remodeling complex 9e-050.00145 S000001406TID3YIL144WverifiedComponent of the evolutionarily conservedkinetochore-associated Ndc80 complex(Ndc80p-Nuf2p-Spc24p-Spc25p); conservedcoiled-coil protein involved in chromosomesegregation, spindle checkpoint activity,kinetochore assembly and clustering 9e-050.00145 S000000775PAU2YEL049WverifiedPart of 23-member seripauperin multigene family encoded mainlyin subtelomeric regions, active duringalcoholic fermentation, regulated byanaerobiosis, negatively regulated by oxygen,repressed by heme 9e-050.00145 S000002632HTB1YDR224CverifiedOne of two nearly identical (see HTB2) histone H2B subtypesrequired for chromatin assembly and chromosomefunction; Rad6p-Bre1p-Lge1p mediatedubiquitination regulates transcriptionalactivation, meiotic DSB formation and H3methylation 9e-050.00145 S000001866CAF16YFL028CverifiedPart of the evolutionarily-conserved CCR4-NOT transcriptionalregulatory complex involved in controlling mRNAinitiation, elongation, and degradation;putative ABC ATPase; interacts with Ssn2p,Ssn3p, and Ssn8p 9e-050.00145 S000001780SIS2YKR072CverifiedNegative regulatory subunit of the protein phosphatase 1 Ppz1p;involved in ion homeostasis and cell cycleprogression 9e-050.00145 S000002640HEM1YDR232Wverified5-aminolevulinate synthase, catalyzes the first step in theheme biosynthetic pathway; an N-terminal signalsequence is required for localization to themitochondrial matrix; expression is regulatedby Hap2p-Hap3p 9e-050.00145 S000002151YBL111CUncharacterizedHelicase-like protein encoded within the telomeric Y' element 9e-050.00145 S000001540NUP120YKL057CverifiedSubunit of the Nup84p subcomplex of the nuclear pore complex(NPC), required for even distribution of NPCsaround the nuclear envelope, involved inestablishment of a normal nucleocytoplasmicconcentration gradient of the GTPase Gsp1p 9e-050.00145 S000005823TIM18YOR297CverifiedComponent of the mitochondrial Tim54p-Tim22p complex involvedin insertion of polytopic proteins into theinner membrane; may function to stabilize thecomplex 9e-050.00145 S000005091LSM7YNL147WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 9e-050.00145&radic S000001847RGD2YFL047WverifiedGTPase-activating protein (RhoGAP) for Cdc42p and Rho5p 9e-050.00145 S000004798HSC82YMR186WverifiedCytoplasmic chaperone of the Hsp90 family, redundant infunction and nearly identical with Hsp82p, andtogether they are essential; expressedconstitutively at 10-fold higher basal levelsthat HSP82 and induced 2-3 fold by heat shock 9e-050.00145 S000003805VPS55YJR044CverifiedLate endosomal protein involved in late endosome to vacuoletrafficking; functional homolog of humanobesity receptor gene-related protein (OB-RGRP) 9e-050.00145 S000002932AGE1YDR524CverifiedADP-ribosylation factor (ARF) GTPase activating protein (GAP)effector, involved in the secretory andendocytic pathways; contains C2C2H2cysteine/histidine motif 9e-050.00145 S000005239YNL295WUncharacterizedHypothetical protein 9e-050.00145 S000003245SNU71YGR013WverifiedComponent of U1 snRNP required for mRNA splicing viaspliceosome; yeast specific, no metazoancounterpart 9e-050.00145&radic S000006097TRE1YPL176CverifiedPlasma membrane localized protein of unknown function; containssequence similarity to the transferrin receptor 9e-050.00145 S000003905MGM101YJR144WverifiedProtein involved in mitochondrial genome maintenance; componentof the mitochondrial nucleoid, required for therepair of oxidative mtDNA damage 9e-050.00145 S000003135PMR1YGL167CverifiedHigh affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ andMn2+ transport into Golgi; involved in Ca2+dependent protein sorting and processing;mutations in human homolog ATP2C1 causeacantholytic skin condition Hailey-Haileydisease 9e-050.00145 S000003370TPO2YGR138CverifiedPolyamine transport protein specific for spermine; localizes tothe plasma membrane; transcription of TPO2 isregulated by Haa1p; member of the majorfacilitator superfamily 9e-050.00145 S000002694YDR286CUncharacterizedHypothetical protein 9e-050.00145 S000003725RPL39YJL189WverifiedProtein component of the large (60S) ribosomal subunit, hassimilarity to rat L39 ribosomal protein;required for ribosome biogenesis; exhibitsgenetic interactions with SIS1 and PAB1 9e-050.00145 S000005633RGS2YOR107WverifiedNegative regulator of glucose-induced cAMP signaling; directlyactivates the GTPase activity of theheterotrimeric G protein alpha subunit Gpa2p 9e-050.00145 S000004386CST9YLR394WverifiedSUMO E3 ligase; required for synaptonemal complex formation;localizes to synapsis initiation sites onmeiotic chromosomes; potential Cdc28p substrate 9e-050.00145 S000003444SLI1YGR212WuncharacterizedN-acetyltransferase, confers resistance to the sphingolipidbiosynthesis inhibitor myriocin (ISP-1) byconverting it into N-acetyl-myriocin,co-operates with Ypk1p in mediating resistanceto myriocin 9e-050.00145 S000000881YER079WUncharacterizedHypothetical protein 9e-050.00145 S000003457AMA1YGR225WverifiedActivator of meiotic anaphase promoting complex (APC/C); Cdc20pfamily member; required for initiation of sporewall assembly; required for Clb1p degradationduring meiosis 9e-050.00145 S000006036BEM3YPL115CverifiedRho GTPase activating protein (RhoGAP) involved in control ofthe cytoskeleton organization; targets theessential Rho-GTPase Cdc42p, which controlsestablishment and maintenance of cell polarity,including bud-site assembly 9e-050.00145 S000003097RSM23YGL129CverifiedMitochondrial ribosomal protein of the small subunit, hassimilarity to mammalian apoptosis mediatorproteins; null mutation prevents induction ofapoptosis by overproduction of metacaspaseMca1p 9e-050.00145 S000002960YER093C-AUncharacterizedHypothetical protein 9e-050.00145 S000006269ROX1YPR065WverifiedHeme-dependent repressor of hypoxic genes; contains an HMGdomain that is responsible for DNA bendingactivity 9e-050.00145 S000004914DYN3YMR299CverifiedDynein light intermediate chain (LIC); localizes with dynein,null mutant is defective in nuclear migration 9e-050.00145 S000003623TRL1YJL087CverifiedtRNA ligase, required for tRNA splicing; composed of threeessential domains containing thephosphodiesterase, polynucleotide kinase, andligase activities required for ligation;localized at the inner membrane of the nuclearenvelope 9e-050.00145 S000001390MET18YIL128WverifiedDNA repair and TFIIH regulator, required for both nucleotideexcision repair (NER) and RNA polymerase II(RNAP II) transcription; involved in telomeremaintenance 9e-050.00145 S000001118PTC7YHR076WverifiedMitochondrially localized type 2C protein phosphatase;expression induced by growth on ethanol and bysustained osmotic stress; possible role incarbon source utilization in low oxygenenvironments 9e-050.00145 S000004698AIP1YMR092CverifiedActin cortical patch component, interacts with the actindepolymerizing factor cofilin; required torestrict cofilin localization to corticalpatches; contains WD repeats 9e-050.00145 S000003011DST1YGL043WverifiedGeneral transcription elongation factor TFIIS, enables RNApolymerase II to read through blocks toelongation by stimulating cleavage of nascenttranscripts stalled at transcription arrestsites 9e-050.00145 S000004339KAP95YLR347CverifiedKaryopherin beta, forms a dimeric complex with Srp1p (Kap60p)that mediates nuclear import of cargo proteinsvia a nuclear localization signal (NLS),interacts with nucleoporins to guide transportacross the nuclear pore complex 9e-050.00145 S000001635GPM1YKL152CverifiedTetrameric phosphoglycerate mutase, mediates the conversion of3-phosphoglycerate to 2-phosphoglycerate duringglycolysis and the reverse reaction duringgluconeogenesis 9e-050.00145 S000003004YGL036WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YGL036W is not an essential gene 9e-050.00145 S000002289LYS21YDL131WverifiedHomocitrate synthase isozyme, catalyzes the condensation ofacetyl-CoA and alpha-ketoglutarate to formhomocitrate, which is the first step in thelysine biosynthesis pathway; highly similar tothe other isozyme, Lys20p 9e-050.00145 S000001280RPL2BYIL018WverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl2Ap and has similarity to E.coli L2 and rat L8 ribosomal proteins;expression is upregulated at low temperatures 9e-050.00145 S000003820PTK2YJR059WverifiedPutative serine/threonine protein kinase involved in regulationof ion transport across plasma membrane;enhances spermine uptake 9e-050.00145 S000005605ATX2YOR079CverifiedGolgi membrane protein involved in manganese homeostasis;overproduction suppresses the sod1 (copper,zinc superoxide dismutase) null mutation 9e-050.00145 S000003126RCK1YGL158WverifiedProtein kinase involved in the response to oxidative stress;identified as suppressor of S. pombe cell cyclecheckpoint mutations 9e-050.00145 S000002633HTA1YDR225WverifiedOne of two nearly identical (see also HTA2) histone H2Asubtypes; core histone required for chromatinassembly and chromosome function; DNAdamage-dependent phosphorylation by Mec1pfacilitates DNA repair; acetylated by Nat4p 9e-050.00145&radic S000002500DNF2YDR093WverifiedAminophospholipid translocase (flippase) that localizesprimarily to the plasma membrane; contributesto endocytosis, protein transport and cellpolarity; type 4 P-type ATPase 9e-050.00145 S000005875PUT4YOR348CverifiedProline permease, required for high-affinity transport ofproline; also transports the toxic prolineanalog azetidine-2-carboxylate (AzC); PUT4transcription is repressed in ammonia-growncells 9e-050.00145 S000001275PDR11YIL013CverifiedMembrane protein of the ATP-binding cassette (ABC) transportersuperfamily, involved in multiple drugresistance, mediates sterol uptake when sterolbiosynthesis is compromised, regulated byPdr1p, required for anaerobic growth 9e-050.00145 S000005491YOL131WUncharacterizedPutative protein of unknown function 9e-050.00144 S000004480YML018CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; YML018C is not an essential gene 9e-050.00144 S000003377ENP2YGR145WuncharacterizedEssential nucleolar protein of unknown function; contains WDrepeats, interacts with Mpp10p and Bfr2p, andhas homology to Spb1p 9e-050.00144 S000007226YER039C-AUncharacterizedPutative protein of unknown function; YER039C-A is not an essential gene 9e-050.00144 S000001057MIP6YHR015WverifiedPutative RNA-binding protein, interacts with Mex67p, which is acomponent of the nuclear pore involved innuclear mRNA export 9e-050.00144 S000000007SPO7YAL009WverifiedIntegral nuclear/ER membrane protein of unknown function,required for normal nuclear envelope morphologyand sporulation 9e-050.00144 S000001277BAR1YIL015WverifiedAspartyl protease secreted into the periplasmic space of matingtype a cells, helps cells find mating partners,cleaves and inactivates alpha factor allowingcells to recover from alpha-factor-induced cellcycle arrest 9e-050.00144 S000004069SIC1YLR079WverifiedInhibitor of Cdc28-Clb kinase complexes that controls G1/Sphase transition, preventing premature S phaseand ensuring genomic integrity; phosphorylationtargets Sic1p for SCF(CDC4)-dependent turnover;functional homolog of mammalian Kip1 9e-050.00144 S000003012RNA15YGL044CverifiedCleavage and polyadenylation factor I (CF I) component involvedin cleavage and polyadenylation of mRNA 3'ends; interacts with the A-rich polyadenylationsignal in complex with Rna14p and Hrp1p 9e-050.00144 S000005485TRM13YOL125WuncharacterizedHypothetical protein 9e-050.00144 S000006038IDI1YPL117CverifiedIsopentenyl diphosphate:dimethylallyl diphosphate isomerase(IPP isomerase), catalyzes an essentialactivation step in the isoprenoid biosyntheticpathway; required for viability 9e-050.00144 S000004748SIP5YMR140WverifiedProtein of unknown function; interacts with both theReg1p/Glc7p phosphatase and the Snf1p kinase 9e-050.00144 S000028598YBL100W-CUncharacterizedIdentified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 9e-050.00144 S000004755YMR147WUncharacterizedHypothetical protein 9e-050.00144 S000003977YLL054CUncharacterizedPutative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene 9e-050.00144 S000002293RPL41BYDL133C-AverifiedRibosomal protein L47 of the large (60S) ribosomal subunit,identical to Rpl41Ap and has similarity to ratL41 ribosomal protein; comprised of only 25amino acids; rpl41a rpl41b double null mutantis viable 9e-050.00144 S000006260TFB4YPR056WverifiedSubunit of TFIIH complex, involved in transcription initiation,similar to 34 kDa subunit of human TFIIH;interacts with Ssl1p 9e-050.00144 S000003512PXR1YGR280CverifiedEssential protein involved in rRNA and snoRNA maturation;competes with TLC1 RNA for binding to Est2p,suggesting a role in regulation of telomerase;human homolog inhibits telomerase; contains aG-patch RNA interacting domain 9e-050.00144 S000003964SDH2YLL041CverifiedIron-sulfur protein subunit of succinate dehydrogenase (Sdh1p,Sdh2p, Sdh3p, Sdh4p), which couples theoxidation of succinate to the transfer ofelectrons to ubiquinone 9e-050.00144 S000003744NUC1YJL208CverifiedMajor mitochondrial nuclease, has RNAse and DNA endo- andexonucleolytic activities; has a role inmitochondrial recombination 9e-050.00144 S000002277YDL119CUncharacterizedPutative mitochondrial transport protein; localizes to the mitochondrion; YDL119C is not an essential gene 9e-050.00144 S000005599SGO1YOR073WverifiedComponent of the spindle checkpoint, involved in sensing lackof tension on mitotic chromosomes; protectscentromeric Rec8p at meiosis I; required foraccurate chromosomal segregation at meiosis IIand for mitotic chromosome stability 9e-050.00144 S000004542BET5YML077WverifiedComponent of the TRAPP (transport protein particle) complex,which plays an essential role in the vesiculartransport from endoplasmic reticulum to Golgi 9e-050.00144 S000003163GCN1YGL195WverifiedPositive regulator of the Gcn2p kinase activity, forms acomplex with Gcn20p; proposed to stimulateGcn2p activation by an uncharged tRNA 9e-050.00144 S000002955YEL076C-AUncharacterizedHypothetical protein 9e-050.00144 S000001752UIP5YKR044WverifiedProtein of unknown function that interacts with Ulp1p, a Ubl(ubiquitin-like protein)-specific protease forSmt3p protein conjugates 9e-050.00144 S000005166SSU72YNL222WverifiedTranscription/RNA-processing factor that associates with TFIIBand cleavage/polyadenylation factor Pta1p;exhibits phosphatase activity on serine-5 ofthe RNA polymerase II C-terminal domain;affects start site selection in vivo 9e-050.00144 S000002714YDR306CUncharacterizedF-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain 9e-050.00144 S000006137YPL216WUncharacterizedHypothetical protein 9e-050.00144 S000029705YCL012CVerifiedPutative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene 9e-050.00144 S000003969RNP1YLL046CverifiedRibonucleoprotein that contains two RNA recognition motifs(RRM) 9e-050.00144 S000002466UBC5YDR059CverifiedUbiquitin-conjugating enzyme that mediates selectivedegradation of short-lived and abnormalproteins, central component of the cellularstress response; expression is heat inducible 9e-050.00144&radic S000001121IRE1YHR079CverifiedSerine-threonine kinase and endoribonuclease; transmembraneprotein that initiates the unfolded proteinresponse signal by regulating synthesis ofHac1p through HAC1 mRNA splicing 9e-050.00144 S000001909IOC3YFR013WverifiedMember of a complex (Isw1a) with Isw1p that hasnucleosome-stimulated ATPase activity andrepresses transcription initiation by specificpositioning of a promoter proximaldinucleosome; has homology to Esc8p, which isinvolved in silencing 9e-050.00144 S000003837CDC11YJR076CverifiedComponent of the septin ring of the mother-bud neck that isrequired for cytokinesis; septins recruitproteins to the neck and can act as a barrierto diffusion at the membrane, and they comprisethe 10nm filaments seen with EM 9e-050.00144 S000005134YNL190WUncharacterizedHypothetical protein 9e-050.00144 S000005196MRPL17YNL252CverifiedMitochondrial ribosomal protein of the large subunit 9e-050.00144 S000001690YKL207WUncharacterizedHypothetical protein 9e-050.00144 S000005369MDM12YOL009CverifiedMitochondrial outer membrane protein, required for transmissionof mitochondria to daughter cells; exists in acomplex with Mmm1p and Mdm10p 9e-050.00144 S000005763HES1YOR237WverifiedProtein implicated in the regulation of ergosterolbiosynthesis; one of a seven member gene familywith a common essential function andnon-essential unique functions; similar tohuman oxysterol binding protein (OSBP) 9e-050.00144 S000003205MTO1YGL236CverifiedMitochondrial protein, forms a heterodimer complex with Mss1pthat performs the 5-carboxymethylaminomethylmodification of the wobble uridine base inmitochondrial tRNAs; required for respirationin paromomycin-resistant 15S rRNA mutants 9e-050.00144 S000003076YGL108CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery 9e-050.00144 S000000926DSE1YER124CverifiedDaughter cell-specific protein, may participate in pathwaysregulating cell wall metabolism; deletionaffects cell separation after division andsensitivity to drugs targeted against the cellwall 9e-050.00144 S000004917YME2YMR302CverifiedIntegral inner mitochondrial membrane protein with similarityto exonucleases; mutants exhibit an increasedrate of mitochondrial DNA escape 9e-050.00144 S000003416UBR1YGR184CverifiedUbiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2pto ubiquitinate substrates of the N-end rulepathway; binds to the Rpn2p, Rpt1p, and Rpt6pproteins of the 19S particle of the 26Sproteasome 9e-050.00144 S000001786YKR078WVerifiedCytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) 9e-050.00144 S000004064BUD20YLR074CverifiedProtein involved in bud-site selection; diploid mutants displaya random budding pattern instead of thewild-type bipolar pattern 9e-050.00144 S000006394RPC82YPR190CverifiedRNA polymerase III subunit C82 9e-050.00144 S000001000YHL008CUncharacterizedPutative protein of unknown function, does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole 9e-050.00144 S000003864URA8YJR103WverifiedMinor CTP synthase isozyme (see also URA7), catalyzes theATP-dependent transfer of the amide nitrogenfrom glutamine to UTP, forming CTP, the finalstep in de novo biosynthesis of pyrimidines;involved in phospholipid biosynthesis 9e-050.00144 S000005214ALP1YNL270CverifiedBasic amino acid transporter, involved in uptake of cationicamino acids 9e-050.00144 S000002668SWM1YDR260CverifiedSubunit of the anaphase-promoting complex, which is an E3ubiquitin ligase that regulates themetaphase-anaphase transition and exit frommitosis; required for activation of thedaughter-specific gene expression and sporewall maturation 9e-050.00144 S000001088INM1YHR046CverifiedInositol monophosphatase, involved in biosynthesis of inositoland in phosphoinositide second messengersignaling; INM1 expression increases in thepresence of inositol and decreases uponexposure to antibipolar drugs lithium andvalproate 9e-050.00144 S000000256RFS1YBR052CuncharacterizedProtein of unknown function; member of a flavodoxin-like foldprotein family that includes Pst2p and Ycp4p;green fluorescent protein (GFP)-fusion proteinlocalizes to the cytoplasm in a punctatepattern 9e-050.00144 S000003494BUD32YGR262CverifiedProtein kinase proposed to be involved in bud-site selection,telomere uncapping and elongation, andtranscription; component of the EKC/KEOPSprotein complex with Kae1p, Cgi121p, Pcc1p, andGon7p 9e-050.00144 S000005151RIO2YNL207WverifiedEssential serine kinase involved in the processing of the 20Spre-rRNA into mature 18S rRNA; has similarityto Rio1p 9e-050.00144 S000002552TAF12YDR145WverifiedSubunit (61/68 kDa) of TFIID and SAGA complexes, involved inRNA polymerase II transcription initiation andin chromatin modification, similar to histoneH2A 9e-050.00144 S000003118INO80YGL150CverifiedATPase that forms a large complex, containing actin and severalactin-related proteins, that has chromatinremodeling activity and 3' to 5' DNA helicaseactivity in vitro; shows similarity to theSnf2p family of ATPases 9e-050.00144 S000000907NUP157YER105CverifiedAbundant subunit of the nuclear pore complex (NPC), present onboth sides of the NPC, has similarity toNup170p 9e-050.00144 S000113555YDR119W-AUncharacterizedPutative protein of unknown function 9e-050.00144 S000001024GUT1YHL032CverifiedGlycerol kinase, converts glycerol to glycerol-3-phosphate;glucose repression of expression is mediated byAdr1p and Ino2p-Ino4p; derepression ofexpression on non-fermentable carbon sources ismediated by Opi1p and Rsf1p 9e-050.00144 S000000399MSI1YBR195CverifiedSubunit of chromatin assembly factor I (CAF-I), regulates theRAS/cAMP pathway via sequestration of Npr1pkinase; localizes to the nucleus and cytoplasm;homologous to human retinoblastoma bindingproteins RbAp48 and RbAp46 9e-050.00144 S000001288IRR1YIL026CverifiedSubunit of the cohesin complex, which is required for sisterchromatid cohesion during mitosis and meiosisand interacts with centromeres and chromosomearms, essential for viability 9e-050.00144 S000001291YIL029CUncharacterizedPutative protein of unknown function 9e-050.00144 S000000544GID7YCL039WverifiedProtein of unknown function, involved in proteasome-dependentcatabolite inactivation offructose-1,6-bisphosphatase; contains six WD40repeats; computational analysis suggests thatGid7p and Moh1p have similar functions 9e-050.00144 S000003981YLL058WUncharacterizedPutative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene 9e-050.00144 S000003983GTT2YLL060CverifiedGlutathione S-transferase capable of homodimerization;functional overlap with Gtt2p, Grx1p, and Grx2p 9e-050.00144 S000005272MDJ2YNL328CverifiedConstituent of the mitochondrial import motor associated withthe presequence translocase; function overlapswith that of Pam18p; stimulates the ATPaseactivity of Ssc1p to drive mitochondrialimport; contains a J domain 9e-050.00144 S000003155COX4YGL187CverifiedSubunit IV of cytochrome c oxidase, which is the terminalmember of the mitochondrial inner membraneelectron transport chain; N-terminal 25residues of precursor are cleaved duringmitochondrial import 9e-050.00144 S000002984KAP122YGL016WverifiedKaryopherin beta, responsible for import of the Toa1p-Toa2pcomplex into the nucleus; binds to nucleoporinsNup1p and Nup2p; may play a role in regulationof pleiotropic drug resistance 9e-050.00144 S000003713RPL17BYJL177WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl17Ap and has similarity to E.coli L22 and rat L17 ribosomal proteins 9e-050.00144 S000002527TRM1YDR120CverifiedtRNA methyltransferase, localizes to both the nucleus andmitochondrion to produce the modified baseN2,N2-dimethylguanosine in tRNAs in bothcompartments 9e-050.00144 S000001919PES4YFR023WverifiedPoly(A) binding protein, suppressor of DNA polymerase epsilonmutation, similar to Mip6p 9e-050.00144 S000006133PUS1YPL212CverifiedtRNA:pseudouridine synthase, introduces pseudouridines atpositions 26-28, 34-36, 65, and 67 of tRNA;nuclear protein that appears to be involved intRNA export; also acts on U2 snRNA 9e-050.00144 S000004974KTR5YNL029CverifiedPutative mannosyltransferase involved in protein glycosylation;member of the KRE2/MNT1 mannosyltransferasefamily 9e-050.00144 S000003585YJL049WUncharacterizedPutative protein of unknown function; YJL049W is a non-essential gene 9e-050.00144 S000028564YLR156C-AUncharacterizedPutative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-3 9e-050.00144 S000002718SUM1YDR310CverifiedTranscriptional repressor required for mitotic repression ofmiddle sporulation-specific genes; involved intelomere maintenance, regulated by thepachytene checkpoint 9e-050.00144 S000004599ERO1YML130CverifiedThiol oxidase required for oxidative protein folding in theendoplasmic reticulum 9e-050.00144 S000000392NTC20YBR188CverifiedMember of a complex, including Prp19p, that binds to thespliceosome; required for pre-mRNA splicing 9e-050.00144&radic S000002757YPS7YDR349CverifiedPutative GPI-anchored aspartic protease, located in thecytoplasm and endoplasmic reticulum 9e-050.00144 S000000238HMT1YBR034CverifiedNuclear SAM-dependent mono- and asymmetric argininedimethylating methyltransferase that modifieshnRNPs, including Npl3p and Hrp1p, thusfacilitating nuclear export of these proteins;required for viability of npl3 mutants 9e-050.00144 S000001854YFL040WUncharacterizedPutative protein of unknown function; YFL040W is not an essential gene 9e-050.00144 S000002762TRP4YDR354WverifiedAnthranilate phosphoribosyl transferase of the tryptophanbiosynthetic pathway, catalyzes thephosphoribosylation of anthranilate, subject tothe general control system of amino acidbiosynthesis 9e-050.00144 S000001077YHR035WUncharacterizedPutative protein of unknown function; not an essential gene 9e-050.00144 S000001022ECM29YHL030WverifiedMajor component of the proteasome; tethers the proteasome coreparticle to the regulatory particle, andenhances the stability of the proteasome 9e-050.00144 S000028556YIL134C-AUncharacterizedPutative protein of unknown function, identified by fungal homology and RT-PCR 9e-050.00144 S000004966HDA1YNL021WverifiedPutative catalytic subunit of a class II histone deacetylasecomplex that also contains Hda2p and Hda3p;Hda1p interacts with the Hda2p-Hda3p subcomplexto form an active tetramer; deletion increaseshistone H2B, H3 and H4 acetylation 9e-050.00143 S000005021APJ1YNL077WverifiedPutative chaperone of the HSP40 (DNAJ) family; overexpressioninterferes with propagation of the [Psi+]prion; the authentic, non-tagged protein isdetected in highly purified mitochondria inhigh-throughput studies 9e-050.00143 S000000913SWI4YER111CverifiedDNA binding component of the SBF complex (Swi4p-Swi6p), atranscriptional activator that in concert withMBF (Mbp1-Swi6p) regulates late G1-specifictranscription of targets including cyclins andgenes required for DNA synthesis and repair 9e-050.00143 S000005623YOR097CUncharacterizedHypothetical protein 9e-050.00143 S000006406YPR202WUncharacterizedPutative protein of unknown function with similarity to telomere-encoded helicases; YPR202W is not an essential gene; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo 9e-050.00143 S000028857YOR192C-CUncharacterizedIdentified by expression profiling and mass spectrometry 9e-050.00143 S000002129ERP1YAR002C-AverifiedProtein that forms a heterotrimeric complex with Erp2p, Emp24p,and Erv25p; member, along with Emp24p andErv25p, of the p24 family involved in ER toGolgi transport and localized to COPII-coatedvesicles 9e-050.00143 S000005907RDR1YOR380WverifiedTranscriptional repressor involved in the control of multidrugresistance; negatively regulates expression ofthe PDR5 gene; member of the Gal4p family ofzinc cluster proteins 9e-050.00143 S000005141WHI3YNL197CverifiedRNA binding protein that sequesters CLN3 mRNA in cytoplasmicfoci; cytoplasmic retention factor for Cdc28pand associated cyclins; regulates cell fate anddose-dependently regulates the critical cellsize required for passage through Start 9e-050.00143 S000005691SEY1YOR165WverifiedProtein of unknown function, contains two predicted GTP-bindingmotifs GXXXXGKS and DXXG near the N-terminus,homolog of the Arabidopsis gene RHD3 (Root HairDefective) 9e-050.00143 S000005056DBP2YNL112WverifiedEssential ATP-dependent RNA helicase of the DEAD-box proteinfamily, involved in nonsense-mediated mRNAdecay and rRNA processing 9e-050.00143 S000000251FMP23YBR047WuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 9e-050.00143 S000003092MON1YGL124CverifiedProtein required for fusion of cvt-vesicles and autophagosomeswith the vacuole; associates, as a complex withCcz1p, with a perivacuolar compartment;potential Cdc28p substrate 9e-050.00143 S000003793CPR7YJR032WverifiedPeptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzesthe cis-trans isomerization of peptide bondsN-terminal to proline residues; binds to Hsp82pand contributes to chaperone activity 9e-050.00143 S000004157RPS31YLR167WverifiedFusion protein that is cleaved to yield a ribosomal protein ofthe small (40S) subunit and ubiquitin;ubiquitin may facilitate assembly of theribosomal protein into ribosomes; interactsgenetically with translation factor eIF2B 9e-050.00143 S000006219YPR015CUncharacterizedPutative protein of unknown function 9e-050.00143 S000002739GPI8YDR331WverifiedER membrane glycoprotein subunit of theglycosylphosphatidylinositol transamidasecomplex that adds glycosylphosphatidylinositol(GPI) anchors to newly synthesized proteins;human PIG-K protein is a functional homolog 9e-050.00143 S000000949SCC4YER147CverifiedSubunit of cohesin loading factor (Scc2p-Scc4p), a complexrequired for the loading of cohesin complexesonto chromosomes; involved in establishingsister chromatid cohesion during double-strandbreak repair via phosphorylated histone H2AX 9e-050.00143 S000003715PFD1YJL179WverifiedSubunit of heterohexameric prefoldin, which binds cytosolicchaperonin and transfers target proteins to it;involved in the biogenesis of actin and ofalpha- and gamma-tubulin 9e-050.00143 S000004902ABZ2YMR289Wuncharacterized4-amino-4-deoxychorismate lyase, catalyzes the third step inpara-aminobenzoic acid biosynthesis 9e-050.00143 S000001735BCH2YKR027WverifiedMember of the Chs5p-Arf1p-binding proteins (ChAPs), a group of4 related, interacting proteins (Bch1p, Fmp50p,Bud7p, Chs6p) that mediate export of specificcargo proteins, including chitin synthaseChs3p, from the Golgi to plasma membrane 9e-050.00143 S000002860PPN1YDR452WverifiedVacuolar endopolyphosphatase with a role in phosphatemetabolism; functions as a homodimer 9e-050.00143 S000004526PIF1YML061CverifiedDNA helicase involved in telomere formation and elongation;acts as a catalytic inhibitor of telomerase;also plays a role in repair and recombinationof mitochondrial DNA 9e-050.00143 S000001079PUT2YHR037WverifiedDelta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encodedmitochondrial protein involved in utilizationof proline as sole nitrogen source; deficiencyof the human homolog causes HPII, an autosomalrecessive inborn error of metabolism 9e-050.00143 S000004725ASI1YMR119WverifiedPutative integral membrane E3 ubiquitin ligase; acts with Asi2pand Asi3p to ensure the fidelity of SPS-sensorsignalling by maintaining the dormant repressedstate of gene expression in the absence ofinducing signals 9e-050.00143 S000001568MDH1YKL085WverifiedMitochondrial malate dehydrogenase, catalyzes interconversionof malate and oxaloacetate; involved in thetricarboxylic acid (TCA) cycle 9e-050.00143 S000006016EEB1YPL095CverifiedAcyl-coenzymeA:ethanol O-acyltransferase responsible for themajor part of medium-chain fatty acid ethylester biosynthesis during fermentation;possesses short chain esterase activity; may beinvolved in lipid metabolism and detoxification 9e-050.00143 S000028513YJR112W-AUncharacterizedPutative protein of unknown function; identified based on homology to Ashbya gossypii 9e-050.00143 S000004516SUR7YML052WverifiedPutative integral membrane protein; component of eisosomes;associated with endocytosis, along with Pil1pand Lsp1p; sporulation and plasma membranesphingolipid content are altered in mutants 9e-050.00143 S000006408YPR204WUncharacterizedHelicase-like protein encoded within the telomeric Y' element 9e-050.00143 S000000239PDX3YBR035CverifiedPyridoxine (pyridoxamine) phosphate oxidase, has homologs in E.coli and Myxococcus xanthus; transcription isunder the general control of nitrogenmetabolism 9e-050.00143 S000000226POA1YBR022WverifiedPhosphatase that is highly specific for ADP-ribose1''-phosphate, a tRNA splicing metabolite; mayhave a role in regulation of tRNA splicing 9e-050.00143 S000028693YMR182W-AUncharacterizedPutative protein of unknown function 9e-050.00143 S000001776BET3YKR068CverifiedHydrophilic protein that acts in conjunction with SNAREproteins in targeting and fusion of ER to Golgitransport vesicles; component of the TRAPP(transport protein particle) complex 9e-050.00143 S000004202TUB4YLR212CverifiedGamma-tubulin, involved in nucleating microtubules from boththe cytoplasmic and nuclear faces of thespindle pole body 9e-050.00143 S000005074CPT1YNL130CverifiedCholinephosphotransferase, required for phosphatidylcholinebiosynthesis and for inositol-dependentregulation of EPT1 transcription 9e-050.00143 S000006169GAL4YPL248CverifiedDNA-binding transcription factor required for the activation ofthe GAL genes in response to galactose;repressed by Gal80p and activated by Gal3p 9e-050.00143 S000002156RPL19AYBR084C-AverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl19Bp and has similarity to ratL19 ribosomal protein; rpl19a and rpl19b singlenull mutations result in slow growth, while thedouble null mutation is lethal 9e-050.00143 S000004502YMD8YML038CverifiedPutative nucleotide sugar transporter, has similarity to Vrg4p 9e-050.00143 S000002641RTN1YDR233CverifiedER membrane protein that interacts with exocyst subunit Sec6pand with Yip3p; null mutant has an altered(mostly cisternal) ER morphology; hassimilarity to mammalian reticulon proteins andmember of the RTNLA (reticulon-like A)subfamily 9e-050.00143 S000002420PSF1YDR013WverifiedSubunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), whichis localized to DNA replication origins andimplicated in assembly of the DNA replicationmachinery 9e-050.00143 S000000218YBR014CUncharacterizedHypothetical protein 9e-050.00143 S000005637YOR111WUncharacterizedHypothetical protein 9e-050.00143 S000003769TDH2YJR009CverifiedGlyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involvedin glycolysis and gluconeogenesis; tetramerthat catalyzes the reaction ofglyceraldehyde-3-phosphate to 1,3bis-phosphoglycerate; detected in the cytoplasmand cell-wall 9e-050.00143 S000006409YEL077CUncharacterizedHelicase-like protein encoded within the telomeric Y' element 9e-050.00143 S000006040DBP1YPL119CverifiedPutative ATP-dependent RNA helicase of the DEAD-box proteinfamily; mutants show reduced stability of the40S ribosomal subunit scanning through 5'untranslated regions of mRNAs 9e-050.00143 S000004592PHO84YML123CverifiedHigh-affinity inorganic phosphate (Pi) transporter andlow-affinity manganese transporter; regulatedby Pho4p and Spt7p; mutation confers resistanceto arsenate; exit from the ER during maturationrequires Pho86p 9e-050.00143 S000000782HAT2YEL056WverifiedSubunit of the Hat1p-Hat2p histone acetyltransferase complex;required for high affinity binding of thecomplex to free histone H4, thereby enhancingHat1p activity; similar to human RbAp46 and 48;has a role in telomeric silencing 9e-050.00143 S000000908MAM1YER106WverifiedMonopolin, kinetochore associated protein involved inchromosome attachment to meiotic spindle 9e-050.00143 S000004179ATG26YLR189CverifiedUDP-glucose:sterol glucosyltransferase, conserved enzymeinvolved in synthesis of sterol glucosidemembrane lipids, involved in autophagy 9e-050.00143 S000002449YDR042CUncharacterizedHypothetical protein 9e-050.00143 S000000291RFC5YBR087WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon 9e-050.00143 S000001383QDR2YIL121WverifiedMultidrug transporter required for resistance to quinidine,barban, cisplatin, and bleomycin; member of themajor facilitator superfamily of transportersconferring multiple drug resistance (MFS-MDR) 9e-050.00143 S000006183FUM1YPL262WverifiedFumarase, converts fumaric acid to L-malic acid in the TCAcycle; cytosolic and mitochondrial localizationdetermined by the N-terminal mitochondrialtargeting sequence and protein conformation 9e-050.00143 S000002343RPL41AYDL184CverifiedRibosomal protein L47 of the large (60S) ribosomal subunit,identical to Rpl41Bp and has similarity to ratL41 ribosomal protein; comprised of only 25amino acids; rpl41a rpl41b double null mutantis viable 9e-050.00143 S000000195ATP1YBL099WverifiedAlpha subunit of the F1 sector of mitochondrial F1F0 ATPsynthase, which is a large, evolutionarilyconserved enzyme complex required for ATPsynthesis 9e-050.00143 S000000917SPR6YER115CverifiedProtein of unknown function, expressed during sporulation; notrequired for sporulation, but gene exhibitsgenetic interactions with other genes requiredfor sporulation 9e-050.00143 S000004322CHS5YLR330WverifiedProtein involved in export from the Golgi to plasma membrane;involved in chitin biosynthesis through itsrole in Chs3p localization; interacts withArf1p, Bch1p, Fmp50p, Bud7p, and Chs6p 9e-050.00143 S000000490APE3YBR286WverifiedVacuolar aminopeptidase Y, processed to mature form by Prb1p 9e-050.00143 S000007233YDR034C-AUncharacterizedSimilar to probable membrane protein YLR334C and ORF YOL106W 9e-050.00143 S000002211PBP4YDL053CverifiedPbp1p binding protein, interacts strongly with Pab1p-bindingprotein 1 (Pbp1p) in the yeast two-hybridsystem; also interacts with Lsm12p in acopurification assay 9e-050.00143 S000004833ERG8YMR220WverifiedPhosphomevalonate kinase, an essential cytosolic enzyme thatacts in the biosynthesis of isoprenoids andsterols, including ergosterol, from mevalonate 9e-050.00143 S000003752YJL216CUncharacterizedProtein of unknown function, similar to alpha-D-glucosidases; transcriptionally activated by both Pdr8p and Yrm1p, along with transporters and other genes involved in the pleiotropic drug resistance (PDR) phenomenon 9e-050.00143 S000004252YPT6YLR262CverifiedGTPase, Ras-like GTP binding protein involved in the secretorypathway, required for fusion ofendosome-derived vesicles with the late Golgi,maturation of the vacuolar carboxypeptidase Y;has similarity to the human GTPase, Rab6 9e-050.00143 S000001405SSL2YIL143CverifiedComponent of the holoenzyme form of RNA polymerasetranscription factor TFIIH, has DNA-dependentATPase/helicase activity and is required, withRad3p, for unwinding promoter DNA; involved inDNA repair; homolog of human ERCC3 9e-050.00143 S000001329YIL067CUncharacterizedHypothetical protein 9e-050.00143 S000006082BEM4YPL161CverifiedProtein involved in establishment of cell polarity and budemergence; interacts with the Rho1p smallGTP-binding protein and with the Rho-typeGTPase Cdc42p; involved in maintenance ofproper telomere length 9e-050.00143 S000005698YRM1YOR172WverifiedZn2-Cys6 zinc-finger transcription factor that activates genesinvolved in multidrug resistance; paralog ofYrr1p, acting on an overlapping set of targetgenes 9e-050.00143 S000003109HUL5YGL141WverifiedProtein with similarity to hect domain E3 ubiquitin-proteinligases, not essential for viability 9e-050.00143 S000004349RSC2YLR357WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; involvedin telomere maintenance 9e-050.00143 S000001868STE2YFL026WverifiedReceptor for alpha-factor pheromone; seven transmembrane-domainGPCR that interacts with both pheromone and aheterotrimeric G protein to initiate thesignaling response that leads to mating betweenhaploid a and alpha cells 9e-050.00143 S000003922COS5YJR161CverifiedProtein of unknown function, member the DUP380 subfamily ofconserved, often subtelomerically-encodedproteins 9e-050.00143 S000004932YMR315WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR315W is not an essential gene 9e-050.00143 S000005232CAF40YNL288WverifiedEvolutionarily conserved subunit of the CCR4-NOT complexinvolved in controlling mRNA initiation,elongation and degradation; binds Cdc39p 9e-050.00143 S000004667RIM9YMR063WverifiedProtein of unknown function, involved in the proteolyticactivation of Rim101p in response to alkalinepH; has similarity to A. nidulans PalI;putative membrane protein 9e-050.00143 S000004536COG8YML071CverifiedComponent of the conserved oligomeric Golgi complex (Cog1pthrough Cog8p), a cytosolic tethering complexthat functions in protein trafficking tomediate fusion of transport vesicles to Golgicompartments 9e-050.00143 S000001770TFA2YKR062WverifiedTFIIE small subunit, involved in RNA polymerase IItranscription initiation 9e-050.00143 S000001651KKQ8YKL168CverifiedPutative serine/threonine protein kinase with unknown cellularrole 9e-050.00143 S000005228MRPL10YNL284CverifiedMitochondrial ribosomal protein of the large subunit; appearsas two protein spots (YmL10 and YmL18) ontwo-dimensional SDS gels 9e-050.00143 S000004740REC114YMR133WverifiedProtein involved in early stages of meiotic recombination;possibly involved in the coordination ofrecombination and meiotic division; mutationslead to premature initiation of the firstmeiotic division 9e-050.00143 S000003455HSV2YGR223CverifiedPhosphatidylinositol 3,5-bisphosphate-binding protein,predicted to fold as a seven-bladedbeta-propeller; displays punctate cytoplasmiclocalization 9e-050.00143 S000005493HRT1YOL133WverifiedRING finger containing subunit of Skp1-Cullin-F-box ubiquitinprotein ligases (SCF); required for Gic2p,Far1p, Sic1p and Cln2p degradation; may tetherCdc34p (a ubiquitin conjugating enzyme or E2)and Cdc53p (a cullin) subunits of SCF 9e-050.00143 S000005825BUD7YOR299WverifiedMember of the Chs5p-Arf1p-binding proteins (ChAPs), a group of4 related, interacting proteins (Bch1p, Fmp50p,Bud7p, Chs6p) that mediate export of specificcargo proteins, including chitin synthaseChs3p, from the Golgi to plasma membrane 9e-050.00143 S000004598COX14YML129CverifiedMitochondrial membrane protein, required for assembly ofcytochrome c oxidase 9e-050.00143 S000028547YFL041W-AUncharacterizedPutative protein of unknown function; identified by fungal homology and RT-PCR 9e-050.00143 S000000107SCT1YBL011WverifiedGlycerol 3-phosphate/dihydroxyacetone phosphate dualsubstrate-specific sn-1 acyltransferase of theglycerolipid biosynthesis pathway, prefers16-carbon fatty acids, similar to Gpt2p, geneis constitutively transcribed 9e-050.00143 S000006258SMK1YPR054WverifiedMiddle sporulation-specific mitogen-activated protein kinase(MAPK) required for production of the outerspore wall layers; negatively regulatesactivity of the glucan synthase subunit Gsc2p 9e-050.00143 S000000357RIB7YBR153WverifiedDiaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzesthe second step of the riboflavin biosynthesispathway 9e-050.00143 S000000396RIM2YBR192WverifiedMitochondrial pyrimidine nucleotide transporter; importspyrimidine nucleoside triphosphates and exportspyrimidine nucleoside monophosphates; member ofthe mitochondrial carrier family 9e-050.00143 S000005987YPL066WUncharacterizedHypothetical protein 9e-050.00143 S000001547MNR2YKL064WverifiedPutative magnesium transporter; has similarity to Alr1p andAlr2p, which mediate influx of Mg2+ and otherdivalent cations 9e-050.00143 S000002511SPO71YDR104CverifiedMeiosis-specific protein of unknown function, required forspore wall formation during sporulation;dispensable for both nuclear divisions duringmeiosis 9e-050.00143 S000005542ERP4YOR016CverifiedProtein with similarity to Emp24p and Erv25p, member of the p24family involved in ER to Golgi transport 9e-050.00143 S000004464TRM12YML005WverifiedS-adenosylmethionine-dependent methyltransferase of the sevenbeta-strand family; required for wybutosineformation in phenylalanine-accepting tRNA 9e-050.00143 S000001874PAU5YFL020CverifiedPart of 23-member seripauperin multigene family encoded mainlyin subtelomeric regions, active duringalcoholic fermentation, regulated byanaerobiosis, negatively regulated by oxygen,repressed by heme 9e-050.00143 S000000223GAL10YBR019CverifiedUDP-glucose-4-epimerase, catalyzes the interconversion ofUDP-galactose and UDP-D-glucose in galactosemetabolism; also catalyzes the conversion ofalpha-D-glucose or alpha-D-galactose to theirbeta-anomers 9e-050.00143 S000001431YIL169CUncharacterizedPutative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene 9e-050.00143 S000003114YGL146CUncharacterizedHypothetical protein 9e-050.00143 S000003829RFC2YJR068WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon 9e-050.00143 S000004444SST2YLR452CverifiedGTPase-activating protein for Gpa1p, regulates desensitizationto alpha factor pheromone; also required toprevent receptor-independent signaling of themating pathway; member of the RGS (regulator ofG-protein signaling) family 9e-050.00143 S000005711GSP2YOR185CverifiedGTP binding protein (mammalian Ranp homolog) involved in themaintenance of nuclear organization, RNAprocessing and transport; interacts withKap121p, Kap123p and Pdr6p (karyophilin betas);Gsp1p homolog that is not required forviability 9e-050.00143 S000007264AI4Q0065verifiedEndonuclease I-SceII, encoded by a mobile group I intron withinthe mitochondrial COX1 gene; intron is normallyspliced by the BI4p maturase but AI4p canmutate to acquire the same maturase activity 9e-050.00143 S000000729GIM4YEL003WverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it