Yfunc lets you browse current and predicted gene functions in yeast

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Prediction of GO:0003677 "DNA binding"

GO branch: MF
Number of currently annotated genes: 221

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest Huh:cytoplasmHuh:nucleusKumar:nucleusHarbison:UGA3_YPDKumar:cyto.Lum:FlurbiprofenLum:SulfanilamideLum:CamptothecinTucker:perLum:Caffeine S000000688MSH3YCR092CverifiedMismatch repair protein, forms dimers with Msh2p that mediaterepair of insertion or deletion mutations andremoval of nonhomologous DNA ends, contains aPCNA (Pol30p) binding motif required for genomestability &radic0.59610.95765&radic&radic&radic&radic S000005450MSH2YOL090WverifiedProtein that forms heterodimers with Msh3p and Msh6p that bindto DNA mismatches to initiate the mismatchrepair process; contains a Walker ATP-bindingmotif required for repair activity; Msh2p-Msh6pbinds to and hydrolyzes ATP &radic0.603740.95765&radic&radic&radic&radic S000002504MSH6YDR097CverifiedProtein required for mismatch repair in mitosis and meiosis,forms a complex with Msh2p to repair bothsingle-base & insertion-deletion mispairs;potentially phosphorylated by Cdc28p &radic0.585020.95765&radic&radic&radic&radic S000005372HTZ1YOL012CverifiedHistone variant H2AZ, exchanged for histone H2A in nucleosomesby the SWR1 complex; involved intranscriptional regulation through preventionof the spread of silent heterochromatin 0.592420.95765&radic&radic&radic&radic&radic S000005454RFC4YOL094CverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon &radic0.564250.95765&radic S000005234RFC3YNL290WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon &radic0.556130.95765&radic&radic&radic&radic S000000213HHF1YBR009CverifiedOne of two identical histone H4 proteins (see also HHF2); corehistone required for chromatin assembly andchromosome function; contributes to telomericsilencing; N-terminal domain involved inmaintaining genomic integrity &radic0.619470.95765&radic S000004975HHF2YNL030WverifiedOne of two identical histone H4 proteins (see also HHF1); corehistone required for chromatin assembly andchromosome function; contributes to telomericsilencing; N-terminal domain involved inmaintaining genomic integrity &radic0.589440.95765&radic S000000214HHT1YBR010WverifiedOne of two identical histone H3 proteins (see also HHT2); corehistone required for chromatin assembly,involved in heterochromatin-mediated telomericand HM silencing; regulated by acetylation,methylation, and mitotic phosphorylation &radic0.5920.95765&radic&radic S000002633HTA1YDR225WverifiedOne of two nearly identical (see also HTA2) histone H2Asubtypes; core histone required for chromatinassembly and chromosome function; DNAdamage-dependent phosphorylation by Mec1pfacilitates DNA repair; acetylated by Nat4p &radic0.534580.95695&radic&radic&radic S000004976HHT2YNL031CverifiedOne of two identical histone H3 proteins (see also HHT1); corehistone required for chromatin assembly,involved in heterochromatin-mediated telomericand HM silencing; regulated by acetylation,methylation, and mitotic phosphorylation &radic0.513720.95304&radic S000006308FHL1YPR104CverifiedPutative transcriptional regulator with similarity toDNA-binding domain of Drosophila forkhead;required for rRNA processing &radic0.499390.94814&radic&radic S000002632HTB1YDR224CverifiedOne of two nearly identical (see HTB2) histone H2B subtypesrequired for chromatin assembly and chromosomefunction; Rad6p-Bre1p-Lge1p mediatedubiquitination regulates transcriptionalactivation, meiotic DSB formation and H3methylation &radic0.491620.94787&radic&radic&radic&radic S000000099HTA2YBL003CverifiedOne of two nearly identical (see also HTA1) histone H2Asubtypes; core histone required for chromatinassembly and chromosome function; DNAdamage-dependent phosphorylation by Mec1pfacilitates DNA repair; acetylated by Nat4p &radic0.477040.9465&radic&radic&radic S000003829RFC2YJR068WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon &radic0.481890.9465&radic&radic S000001532CSE4YKL049CverifiedCentromere protein that resembles histones, required for properkinetochore function; homolog of human CENP-A &radic0.481270.9465&radic&radic&radic&radic S000000098HTB2YBL002WverifiedOne of two nearly identical (see HTB1) histone H2B subtypesrequired for chromatin assembly and chromosomefunction; Rad6p-Bre1p-Lge1p mediatedubiquitination regulates transcriptionalactivation, meiotic DSB formation and H3methylation &radic0.471130.94117&radic S000001393FKH1YIL131CverifiedForkhead family transcription factor with a minor role in theexpression of G2/M phase genes; negativelyregulates transcriptional elongation; positiverole in chromatin silencing at HML and HMR;regulates donor preference during switching &radic0.463070.93854&radic S000005012FKH2YNL068CverifiedForkhead family transcription factor with a major role in theexpression of G2/M phase genes; positivelyregulates transcriptional elongation; negativerole in chromatin silencing at HML and HMR;substrate of the Cdc28p/Clb5p kinase &radic0.465870.93854&radic S000002259DUN1YDL101CverifiedCell-cycle checkpoint serine-threonine kinase required for DNAdamage-induced transcription of certain targetgenes, phosphorylation of Rad55p and Sml1p, andtransient G2/M arrest after DNA damage; alsoregulates postreplicative DNA repair 0.437770.9357&radic&radic&radic S000004646MCM1YMR043WverifiedTranscription factor involved in cell-type-specifictranscription and pheromone response; plays acentral role in the formation of both repressorand activator complexes &radic0.438440.9357&radic&radic S000000572HMLALPHA2YCL067CverifiedSilenced copy of ALPHA2 at HML; homeobox-domain protein thatassociates with Mcm1p in haploid cells torepress a-specific gene expression andinteracts with a1p in diploid cells to represshaploid-specific gene expression 0.428620.93241&radic S000000913SWI4YER111CverifiedDNA binding component of the SBF complex (Swi4p-Swi6p), atranscriptional activator that in concert withMBF (Mbp1-Swi6p) regulates late G1-specifictranscription of targets including cyclins andgenes required for DNA synthesis and repair &radic0.416470.92767&radic&radic S000002214MBP1YDL056WverifiedTranscription factor involved in regulation of cell cycleprogression from G1 to S phase, forms a complexwith Swi6p that binds to MluI cell cycle boxregulatory element in promoters of DNAsynthesis genes &radic0.412330.92767&radic&radic&radic&radic S000002530INO2YDR123CverifiedComponent of the heteromeric Ino2p/Ino4p basic helix-loop-helixtranscription activator that bindsinositol/choline-responsive elements (ICREs),required for derepression of phospholipidbiosynthetic genes in response to inositoldepletion 0.407780.92363&radic&radic&radic S000006010RLM1YPL089CverifiedMADS-box transcription factor, component of the protein kinaseC-mediated MAP kinase pathway involved in themaintenance of cell integrity; phosphorylatedand activated by the MAP-kinase Slt2p &radic0.392920.91693&radic&radic&radic&radic S000004778CEP3YMR168CverifiedEssential kinetochore protein, component of the CBF3 complexthat binds the CDEIII region of the centromere;contains an N-terminal Zn2Cys6 type zinc fingerdomain, a C-terminal acidic domain, and aputative coiled coil dimerization domain &radic0.391650.91644&radic&radic&radic&radic S000004618SOK2YMR016CverifiedNuclear protein that plays a regulatory role in the cyclic AMP(cAMP)-dependent protein kinase (PKA) signaltransduction pathway; negatively regulatespseudohyphal differentiation; homologous toseveral transcription factors &radic0.389230.91644&radic&radic&radic&radic&radic S000004645ARG80YMR042WverifiedTranscription factor involved in regulation ofarginine-responsive genes; acts with Arg81p andArg82p &radic0.37760.91246&radic&radic&radic S000001873GAT1YFL021WverifiedTranscriptional activator of genes involved in nitrogencatabolite repression, member of the GATAfamily of DNA binding proteins; activity andlocalization regulated by nitrogen limitationand Ure2p 0.377090.91244&radic&radic&radic&radic S000002981PDR1YGL013CverifiedZinc cluster protein that is a master regulator involved inrecruiting other zinc cluster proteins topleiotropic drug response elements (PDREs) tofine tune the regulation of multidrugresistance genes &radic0.37420.91136&radic&radic&radic&radic&radic S000000199RTG3YBL103CverifiedBasic helix-loop-helix-leucine zipper (bHLH/Zip) transcriptionfactor that forms a complex with anotherbHLH/Zip protein, Rtg1p, to activate theretrograde (RTG) and TOR pathways 0.371450.90748&radic&radic S000001668ASH1YKL185WverifiedZinc-finger inhibitor of HO transcription; mRNA is localizedand translated in the distal tip of anaphasecells, resulting in accumulation of Ash1p indaughter cell nuclei and inhibition of HOexpression; potential Cdc28p substrate 0.351020.89986&radic&radic&radic&radic&radic S000002711RSC3YDR303CverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; essential gene required forregulation of ribosomal protein genes and thecell wall/stress response; highly similar toRsc30p &radic0.350150.89797&radic&radic&radic&radic S000003610SMC3YJL074CverifiedSubunit of the multiprotein cohesin complex required for sisterchromatid cohesion in mitotic cells; alsorequired, with Rec8p, for cohesion andrecombination during meiosis; phylogeneticallyconserved SMC chromosomal ATPase family member 0.339830.89546&radic&radic S000001526PHD1YKL043WverifiedTranscriptional activator that enhances pseudohyphal growth;regulates expression of FLO11, an adhesinrequired for pseudohyphal filament formation;similar to StuA, an A. nidulans developmentalregulator; potential Cdc28p substrate &radic0.335830.89199&radic&radic&radic&radic&radic S000004494RAD52YML032CverifiedProtein that stimulates strand exchange by facilitating Rad51pbinding to single-stranded DNA; annealscomplementary single-stranded DNA; involved inthe repair of double-strand breaks in DNAduring vegetative growth and meiosis &radic0.333810.89028&radic&radic&radic&radic&radic&radic S000000386SMP1YBR182CverifiedPutative transcription factor involved in regulating theresponse to osmotic stress; member of theMADS-box family of transcription factors &radic0.327560.88888&radic&radic&radic S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling &radic0.32770.88888&radic&radic&radic&radic&radic&radic&radic S000005428RTG1YOL067CverifiedTranscription factor (bHLH) involved in interorganellecommunication between mitochondria,peroxisomes, and nucleus 0.333250.88888&radic&radic&radic&radic&radic&radic S000000975RAD24YER173WverifiedCheckpoint protein, involved in the activation of the DNAdamage and meiotic pachytene checkpoints;subunit of a clamp loader that loadsRad17p-Mec3p-Ddc1p onto DNA; homolog of humanand S. pombe Rad17 protein &radic0.324380.88698&radic&radic S000004897YKU70YMR284WverifiedSubunit of the telomeric Ku complex (Yku70p-Yku80p), involvedin telomere length maintenance, structure andtelomere position effect; relocates to sites ofdouble-strand cleavage to promote nonhomologousend joining during DSB repair &radic0.323560.88662&radic&radic&radic&radic&radic&radic S000000270NRG2YBR066CverifiedTranscriptional repressor that mediates glucose repression andnegatively regulates filamentous growth; hassimilarity to Nrg1p 0.323450.88662&radic&radic&radic S000001930PHO4YFR034CverifiedBasic helix-loop-helix (bHLH) transcription factor; bindscooperatively with Pho2p to the PHO5 promoter;function is regulated by phosphorylation atmultiple sites and by phosphate availability &radic0.323070.88649&radic&radic&radic&radic&radic&radic S000002625RAD9YDR217CverifiedDNA damage-dependent checkpoint protein, required forcell-cycle arrest in G1/S, intra-S, and G2/M;transmits checkpoint signal by activatingRad53p and Chk1p; hyperphosphorylated by Mec1pand Tel1p; potential Cdc28p substrate 0.320080.8851&radic&radic&radic&radic&radic S000004076SMC4YLR086WverifiedSubunit of the condensin complex, which reorganizes chromosomesduring cell division, forms a stable complexwith Smc2p that has ATP-hydrolyzing andDNA-binding activity and promotes knotting ofcircular DNA; potential Cdc28p substrate 0.318820.88478&radic&radic&radic S000002553SWI5YDR146CverifiedTranscription factor that activates transcription of genesexpressed at the M/G1 phase boundary and in G1phase; localization to the nucleus occursduring G1 and appears to be regulated byphosphorylation by Cdc28p kinase 0.309620.88081&radic&radic&radic S000005890PIP2YOR363CverifiedAutoregulatory oleate-specific transcriptional activator ofperoxisome proliferation, contains Zn(2)-Cys(6)cluster domain, forms heterodimer with Oaf1p,binds oleate response elements (OREs),activates beta-oxidation genes &radic0.305150.8786&radic&radic&radic&radic&radic S000001545MSN4YKL062WverifiedTranscriptional activator related to Msn2p; activated in stressconditions, which results in translocation fromthe cytoplasm to the nucleus; binds DNA atstress response elements of responsive genes,inducing gene expression &radic0.303230.87814&radic S000003821CBF1YJR060WverifiedHelix-loop-helix protein that binds the motif CACRTG, which ispresent at several sites including MET genepromoters and centromere DNA element I (CDEI);required for nucleosome positioning at thismotif; targets Isw1p to DNA &radic0.302090.87797&radic&radic S000002545HPR1YDR138WverifiedSubunit of THO/TREX complexes that couple transcriptionelongation with mitotic recombination and withmRNA metabolism and export, subunit of an RNAPol II complex; regulates lifespan; involved intelomere maintenance; similar to Top1p 0.302820.87797&radic&radic&radic&radic S000003003MIG1YGL035CverifiedTranscription factor involved in glucose repression; C2H2 zincfinger protein similar to mammalian Egr andWilms tumor proteins 0.298670.87708&radic&radic&radic&radic S000002313MSH5YDL154WverifiedProtein of the MutS family, forms a dimer with Msh4p thatfacilitates crossovers between homologs duringmeiosis; msh5-Y823H mutation confers toleranceto DNA alkylating agents; homologs present inC. elegans and humans 0.29730.87557&radic&radic&radic S000000048OAF1YAL051WverifiedOleate-activated transcription factor, acts alone and as aheterodimer with Pip2p; activates genesinvolved in beta-oxidation of fatty acids andperoxisome organization and biogenesis &radic0.294010.87395&radic&radic&radic&radic&radic S000000162SEF1YBL066CverifiedPutative transcription factor, has homolog in Kluyveromyceslactis 0.294640.87395&radic&radic&radic&radic S000004025MLH2YLR035CverifiedProtein required for DNA mismatch repair in mitosis andmeiosis; involved in the repair of mutationalintermediates; forms a complex with Pms1p andMsh1p to repair mismatched DNA 0.293660.87357&radic&radic S000004893CAT8YMR280CverifiedZinc cluster transcriptional activator necessary forderepression of a variety of genes undernon-fermentative growth conditions, activeafter diauxic shift, binds carbon sourceresponsive elements 0.290660.87202&radic&radic S000004712YKU80YMR106CverifiedSubunit of the telomeric Ku complex (Yku70p-Yku80p), involvedin telomere length maintenance, structure andtelomere position effect; relocates to sites ofdouble-strand cleavage to promote nonhomologousend joining during DSB repair &radic0.287540.87019&radic&radic S000003490RAD2YGR258CverifiedSingle-stranded DNA endonuclease, cleaves single-stranded DNAduring nucleotide excision repair to excisedamaged DNA; subunit of Nucleotide ExcisionRepair Factor 3 (NEF3); homolog of human XPGprotein 0.287690.87019&radic&radic S000002615UME6YDR207CverifiedKey transcriptional regulator of early meiotic genes, bindsURS1 upstream regulatory sequence, couplesmetabolic responses to nutritional cues withinitiation and progression of meiosis, formscomplex with Ime1p, and also with Sin3p-Rpd3p &radic0.284660.86966&radic&radic&radic&radic&radic&radic&radic&radic S000004802SGS1YMR190CverifiedNucleolar DNA helicase of the RecQ family involved inmaintenance of genome integrity, regulateschromosome synapsis and meiotic crossing over;has similarity to human BLM and WRN helicasesimplicated in Bloom and Werner syndromes 0.282640.86913&radic&radic&radic&radic&radic S000002624ADR1YDR216WverifiedCarbon source-responsive zinc-finger transcription factor,required for transcription of theglucose-repressed gene ADH2, of peroxisomalprotein genes, and of genes required forethanol, glycerol, and fatty acid utilization &radic0.282670.86913&radic&radic&radic&radic S000002264PHO2YDL106CverifiedHomeobox transcription factor; regulatory targets include genesinvolved in phosphate metabolism; bindscooperatively with Pho4p to the PHO5 promoter;phosphorylation of Pho2p facilitatesinteraction with Pho4p &radic0.273850.8627&radic&radic&radic S000005666SFL1YOR140WverifiedTranscription repressor involved in regulation offlocculation-related genes, inhibitstranscription by recruiting general corepressorCyc8p-Tup1p to different promoters; negativelyregulated by cAMP-dependent protein kinase Asubunit Tpk2p 0.27310.86187&radic&radic&radic&radic S000006256NHP6AYPR052CverifiedHigh-mobility group non-histone chromatin protein, functionallyredundant with Nhp6Bp; homologous to mammalianhigh mobility group proteins 1 and 2; acts torecruit transcription factor Rcs1p to certainpromoters 0.271950.86005&radic&radic S000004279MEC3YLR288CverifiedDNA damage and meiotic pachytene checkpoint protein; subunit ofa heterotrimeric complex (Rad17p-Mec3p-Ddc1p)that forms a sliding clamp, loaded onto partialduplex DNA by a clamp loader complex; homologof human and S. pombe Hus1 &radic0.271040.86005&radic&radic&radic S000004489YOX1YML027WverifiedHomeodomain-containing transcriptional repressor, binds toMcm1p and to early cell cycle boxes (ECBs) inthe promoters of cell cycle-regulated genesexpressed in M/G1 phase; expression is cellcycle-regulated; potential Cdc28p substrate &radic0.270850.86005&radic&radic S000003276RME1YGR044CverifiedZinc finger protein involved in control of meiosis; preventsmeiosis by repressing IME1 expression andpromotes mitosis by activating CLN2 expression;directly repressed by a1-a2 regulator; mediatescell type control of sporulation 0.272090.86005&radic&radic&radic&radic&radic S000000694HMRA1YCR097WverifiedSilenced copy of a1 at HMR; homeobox corepressor that interactswith Alpha2p to repress haploid-specific genetranscription in diploid cells 0.269640.85912 S000004640MSN2YMR037CverifiedTranscriptional activator related to Msn4p; activated in stressconditions, which results in translocation fromthe cytoplasm to the nucleus; binds DNA atstress response elements of responsive genes,inducing gene expression &radic0.269050.85892&radic&radic&radic S000004777MLH1YMR167WverifiedProtein required for mismatch repair in mitosis and meiosis,postmeiotic segregation, and spore viability;forms a complex with Pms1p and Msh2p to repairmismatched DNA; human homolog is associatedwith hereditary non-polyposis colon cancer &radic0.268040.85891&radic&radic&radic&radic&radic S000004565ARG81YML099CverifiedZinc-finger transcription factor of the Zn(2)-Cys(6) binuclearcluster domain type, involved in the regulationof arginine-responsive genes; acts with Arg80pand Arg82p 0.268580.85891&radic&radic&radic&radic S000001098RSC30YHR056CverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; non-essential gene required forregulation of ribosomal protein genes and thecell wall/stress response; highly similar toRsc3p; null mutants are osmosensitive &radic0.267440.85891 S000005026PMS1YNL082WverifiedATP-binding protein required for mismatch repair in mitosis andmeiosis; functions as a heterodimer with Mlh1p,binds double- and single-stranded DNA via itsN-terminal domain, similar to E. coli MutL &radic0.265520.8582&radic&radic S000006074RAD53YPL153CverifiedProtein kinase, required for cell-cycle arrest in response toDNA damage; activated by transautophosphorylation when interacting withhyperphosphorylated Rad9p; also interacts withARS1 and plays a role in initiation of DNAreplication &radic0.265180.85714&radic&radic&radic&radic&radic&radic S000006169GAL4YPL248CverifiedDNA-binding transcription factor required for the activation ofthe GAL genes in response to galactose;repressed by Gal80p and activated by Gal3p &radic0.262660.85634&radic&radic S000002859YHP1YDR451CverifiedOne of two homeobox transcriptional repressors (see alsoYox1p), that bind to Mcm1p and to early cellcycle box (ECB) elements of cell cycleregulated genes, thereby restrictingECB-mediated transcription to the M/G1 interval &radic0.260950.85574&radic S000002581HMO1YDR174WverifiedChromatin associated high mobility group (HMG) family memberinvolved in genome maintenance; rDNA-bindingcomponent of the Pol I transcription system;associates with a 5'-3' DNA helicase and Fpr1p,a prolyl isomerase &radic0.259590.85481&radic&radic S000004022RAD5YLR032WverifiedSingle-stranded DNA-dependent ATPase, involved inpostreplication repair; contains RING fingerdomain &radic0.258350.85344&radic&radic&radic S000002506BMH2YDR099Wverified14-3-3 protein, minor isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others &radic0.256840.85321&radic&radic&radic&radic S000005816SNF2YOR290CverifiedCatalytic subunit of the SWI/SNF chromatin remodeling complexinvolved in transcriptional regulation;contains DNA-stimulated ATPase activity;functions interdependently in transcriptionalactivation with Snf5p and Snf6p 0.253030.85098&radic&radic&radic&radic S000005885HAP5YOR358WverifiedSubunit of the heme-activated, glucose-repressed Hap2/3/4/5CCAAT-binding complex, a transcriptionalactivator and global regulator of respiratorygene expression; required for assembly and DNAbinding activity of the complex &radic0.25240.85089&radic&radic&radic&radic&radic&radic S000002160NHP10YDL002CverifiedProtein related to mammalian high mobility group proteins;likely component of the INO80 complex, which isan ATP-dependent chromatin-remodeling complex 0.251140.85005&radic&radic&radic S000001742DAL80YKR034WverifiedNegative regulator of genes in multiple nitrogen degradationpathways; expression is regulated by nitrogenlevels and by Gln3p; member of the GATA-bindingfamily, forms homodimers and heterodimers withDeh1p &radic0.250470.84929 S000000979BMH1YER177Wverified14-3-3 protein, major isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others &radic0.248630.84839&radic S000001249SKN7YHR206WverifiedNuclear response regulator and transcription factor, part of abranched two-component signaling system;required for optimal induction of heat-shockgenes in response to oxidative stress; involvedin osmoregulation &radic0.247990.84774&radic&radic&radic&radic&radic&radic S000003026RAD6YGL058WverifiedUbiquitin-conjugating enzyme (E2), involved in postreplicationrepair (with Rad18p), sporulation, telomeresilencing, and ubiquitin-mediated N-end ruleprotein degradation (with Ubr1p) 0.246420.84534&radic&radic&radic&radic&radic&radic&radic&radic S000005895RAD17YOR368WverifiedCheckpoint protein, involved in the activation of the DNAdamage and meiotic pachytene checkpoints; withMec3p and Ddc1p, forms a clamp that is loadedonto partial duplex DNA; homolog of human andS. pombe Rad1 and U. maydis Rec1 proteins &radic0.245180.84534&radic&radic&radic&radic&radic S000000842GLN3YER040WverifiedTranscriptional activator of genes regulated by nitrogencatabolite repression (NCR), localization andactivity regulated by quality of nitrogensource &radic0.246130.84534&radic&radic&radic&radic&radic S000003041HSF1YGL073WverifiedTrimeric heat shock transcription factor, activates multiplegenes in response to stresses that includehyperthermia; recognizes variable heat shockelements (HSEs) consisting of inverted NGAANrepeats; posttranslationally regulated &radic0.243510.84264&radic&radic&radic&radic&radic&radic S000002200SIR2YDL042CverifiedConserved NAD+ dependent histone deacetylase of the Sirtuinfamily involved in regulation of lifespan;plays roles in silencing at HML, HMR,telomeres, and the rDNA locus; negativelyregulates initiation of DNA replication 0.2440.84264&radic&radic S000000763RAD23YEL037CverifiedProtein with ubiquitin-like N terminus, recognizes and bindsdamaged DNA (with Rad4p) during nucleotideexcision repair; regulates Rad4p levels,subunit of Nuclear Excision Repair Factor 2(NEF2); homolog of human HR23A and HR23Bproteins &radic0.242940.84229&radic&radic&radic&radic&radic S000002856ADA2YDR448WverifiedTranscription coactivator, component of the ADA and SAGAtranscriptional adaptor/HAT (histoneacetyltransferase) complexes 0.242860.84134&radic&radic&radic S000005364SIN3YOL004WverifiedComponent of the Sin3p-Rpd3p histone deacetylase complex,involved in transcriptional repression andactivation of diverse processes, includingmating-type switching and meiosis; involved inthe maintenance of chromosomal integrity 0.241210.84065&radic&radic S000005111SKO1YNL167CverifiedBasic leucine zipper (bZIP) transcription factor of theATF/CREB family, forms a complex with Tup1p andSsn6p to both activate and represstranscription; cytosolic and nuclear proteininvolved in osmotic and oxidative stressresponses 0.240740.84048&radic&radic&radic&radic&radic S000004530ORC1YML065WverifiedLargest subunit of the origin recognition complex, whichdirects DNA replication by binding toreplication origins and is also involved intranscriptional silencing; may bephosphorylated by Cdc28p &radic0.240370.83976&radic&radic&radic S000005468INO4YOL108CverifiedTranscription factor required for derepression ofinositol-choline-regulated genes involved inphospholipid synthesis; forms a complex, withIno2p, that binds theinositol-choline-responsive element through abasic helix-loop-helix domain &radic0.239550.83947&radic&radic&radic S000003628HPR5YJL092WverifiedDNA helicase and DNA-dependent ATPase involved in DNA repair,required for proper timing of commitment tomeiotic recombination and the transition fromMeiosis I to Meiosis II; potential Cdc28psubstrate 0.236960.83706&radic S000002499UBC13YDR092WverifiedUbiquitin-conjugating enzyme involved in the error-free DNApostreplication repair pathway; interacts withMms2p to assemble ubiquitin chains at the UbLys-63 residue; DNA damage triggersredistribution from the cytoplasm to thenucleus 0.235980.83641&radic&radic&radic&radic S000004683CTF18YMR078CverifiedSubunit of a complex with Ctf8p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion; may have overlappingfunctions with Rad24p in the DNA damagereplication checkpoint 0.235760.83598&radic&radic&radic&radic S000000932YER130CUncharacterizedHypothetical protein 0.232730.8328 S000003712SWI3YJL176CverifiedSubunit of the SWI/SNF chromatin remodeling complex, whichregulates transcription by remodelingchromosomes; required for transcription of manygenes, including ADH1, ADH2, GAL1, HO, INO1 andSUC2 0.232680.8327&radic&radic&radic&radic&radic S000004246HAP1YLR256WverifiedZinc finger transcription factor involved in the complexregulation of gene expression in response tolevels of heme and oxygen; the S288C sequencediffers from other strain backgrounds due to aTy1 insertion in the carboxy terminus 0.232520.8326&radic&radic S000002831CAD1YDR423CverifiedAP-1-like bZIP transcriptional activator involved in multiplestress responses, iron metabolism, andpleiotropic drug resistance; controls a set ofgenes involved in stabilizing proteins, bindsconsensus sequence TTACTAA; 5' UTR containsuORFs 0.231610.83119&radic&radic&radic&radic&radic&radic&radic S000005205ORC5YNL261WverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing &radic0.230970.83109&radic&radic&radic&radic&radic S000004560RAD10YML095CverifiedSingle-stranded DNA endonuclease (with Rad1p), cleavessingle-stranded DNA during nucleotide excisionrepair and double-strand break repair; subunitof Nucleotide Excision Repair Factor 1 (NEF1);homolog of human ERCC1 protein &radic0.230930.83041&radic&radic&radic&radic S000003288RSC1YGR056WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; containstwo essential bromodomains, a bromo-adjacenthomology (BAH) domain, and an AT hook 0.230650.83026&radic&radic S000003646GZF3YJL110CverifiedGATA zinc finger protein and Dal80p homolog that negativelyregulates nitrogen catabolic gene expression bycompeting with Gat1p for GATA site binding;function requires a repressive carbon source;dimerizes with Dal80p and binds to Tor1p &radic0.226810.82994&radic&radic S000001221STB5YHR178WverifiedActivator of multidrug resistance genes, forms a heterodimerwith Pdr1p; contains a Zn(II)2Cys6 zinc fingerdomain that interacts with a PDRE (pleotropicdrug resistance element) in vitro; binds Sin3pin a two-hybrid assay &radic0.227970.82994&radic&radic&radic&radic S000002157NHP6BYBR089C-AverifiedHigh-mobility group non-histone chromatin protein, functionallyredundant with Nhp6Ap; homologous to mammalianhigh mobility group proteins 1 and 2; acts torecruit transcription factor Rcs1p to certainpromoters 0.228950.82994&radic&radic&radic S000000897RAD51YER095WverifiedStrand exchange protein, forms a helical filament with DNA thatsearches for homology; involved in therecombinational repair of double-strand breaksin DNA during vegetative growth and meiosis;homolog of Dmc1p and bacterial RecA protein 0.227030.82994&radic&radic S000000291RFC5YBR087WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon &radic0.227150.82994&radic S000004676ABF2YMR072WverifiedMitochondrial DNA-binding protein involved in mitochondrial DNAreplication and recombination, member of HMG1DNA-binding protein family; activity may beregulated by protein kinase A phosphorylation &radic0.228510.82994&radic S000006400YPR196WUncharacterizednuclear protein (putative) 0.230080.82994&radic&radic&radic S000000101PDR3YBL005WverifiedTranscriptional activator of the pleiotropic drug resistancenetwork, regulates expression of ATP-bindingcassette (ABC) transporters through binding tocis-acting sites known as PDREs (PDR responsiveelements) &radic0.225130.82974&radic&radic&radic&radic&radic S000000635MATALPHA2YCR039CverifiedHomeobox-domain protein that, with Mcm1p, represses a-specificgenes in haploids; acts with A1p to represstranscription of haploid-specific genes indiploids; one of two genes encoded by theMATalpha mating type cassette &radic0.225240.82974&radic&radic S000003813RAD7YJR052WverifiedProtein that recognizes and binds damaged DNA in anATP-dependent manner (with Rad16p) duringnucleotide excision repair; subunit ofNucleotide Excision Repair Factor 4 (NEF4) &radic0.222840.82956&radic&radic&radic S000002871STP1YDR463WverifiedTranscription factor, activated by proteolytic processing inresponse to signals from the SPS sensor systemfor external amino acids; activatestranscription of amino acid permease genes andmay have a role in tRNA processing &radic0.223610.82956&radic S000004972CRZ1YNL027WverifiedTranscription factor that activates transcription of genesinvolved in stress response; nuclearlocalization is positively regulated bycalcineurin-mediated dephosphorylation &radic0.223950.82956&radic S000004674MOT3YMR070WverifiedNuclear transcription factor with two Cys2-His2 zinc fingers;involved in repression of a subset of hypoxicgenes by Rox1p, repression of several DAN/TIRgenes during aerobic growth, and repression ofergosterol biosynthetic genes &radic0.224290.82956&radic&radic&radic S000001472MGA2YIR033WverifiedER membrane protein involved in regulation of OLE1transcription, acts with homolog Spt23p;inactive ER form dimerizes and one subunit isthen activated byubiquitin/proteasome-dependent processingfollowed by nuclear targeting 0.222560.82906&radic&radic&radic S000005256RFA2YNL312WverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination &radic0.222280.82906&radic&radic&radic&radic&radic S000005878MEK1YOR351CverifiedMeiosis-specific serine/threonine protein kinase, functions inmeiotic checkpoint, phosphorylates Red1p,interacts with Hop1p; required for meioticrecombination and normal spore viability 0.218670.82569&radic&radic S000005967ELC1YPL046CverifiedElongin C, forms heterodimer with Ela1p that participates intranscription elongation; expressiondramatically upregulated during sporulation;widely conserved among eukaryotes 0.218730.82569&radic&radic&radic&radic&radic S000001019RIM101YHL027WverifiedTranscriptional repressor involved in response to pH and incell wall construction; required for alkalinepH-stimulated haploid invasive growth andsporulation; activated by proteolyticprocessing; similar to A. nidulans PacC 0.219020.82569&radic&radic&radic&radic&radic&radic&radic&radic S000000119MCM2YBL023CverifiedProtein involved in DNA replication; component of the Mcm2-7hexameric complex that binds chromatin as apart of the pre-replicative complex 0.217130.82557&radic&radic&radic&radic&radic&radic S000002661MET32YDR253CverifiedZinc-finger DNA-binding protein, involved in regulatingexpression of the methionine biosyntheticgenes, similar to Met31p &radic0.216480.82513&radic&radic&radic&radic&radic S000005051YAF9YNL107WverifiedSubunit of both the NuA4 histone H4 acetyltransferase complexand the SWR1 complex, may function toantagonize silencing near telomeres; interactsdirectly with Swc4p, has homology to humanleukemogenic protein AF9, contains a YEATSdomain 0.215670.82381&radic&radic&radic&radic S000005698YRM1YOR172WverifiedZn2-Cys6 zinc-finger transcription factor that activates genesinvolved in multidrug resistance; paralog ofYrr1p, acting on an overlapping set of targetgenes 0.214810.82333&radic&radic&radic&radic&radic S000005639AZF1YOR113WverifiedZinc-finger transcription factor, involved in induction of CLN3transcription in response to glucose; geneticand physical interactions indicate a possiblerole in mitochondrial transcription or genomemaintenance &radic0.213470.82171&radic&radic&radic&radic S000000318RAD16YBR114WverifiedProtein that recognizes and binds damaged DNA in anATP-dependent manner (with Rad7p) duringnucleotide excision repair; subunit ofNucleotide Excision Repair Factor 4 (NEF4);member of the SWI/SNF family &radic0.213410.82171&radic&radic S000004814RAD14YMR201CverifiedProtein that recognizes and binds damaged DNA during nucleotideexcision repair; subunit of Nucleotide ExcisionRepair Factor 1 (NEF1); contains zinc fingermotif; homolog of human XPA protein &radic0.213020.82128&radic&radic&radic&radic&radic&radic&radic S000000866YER064CUncharacterizedNon-essential nuclear protein; null mutation has global effects on transcription 0.213280.82128&radic S000005274RPD3YNL330CverifiedHistone deacetylase; regulates transcription and silencing 0.213010.82109&radic&radic&radic S000005194RAD50YNL250WverifiedSubunit of MRX complex, with Mre11p and Xrs2p, involved inprocessing double-strand DNA breaks invegetative cells, initiation of meiotic DSBs,telomere maintenance, and nonhomologous endjoining &radic0.213010.82041&radic&radic S000005942ECM23YPL021WverifiedNon-essential protein of unconfirmed function; affects pre-rRNAprocessing, may act as a negative regulator ofthe transcription of genes involved inpseudohyphal growth; homologous to Srd1p 0.211350.81968&radic&radic&radic S000000444THI2YBR240CverifiedZinc finger protein of the Zn(II)2Cys6 type, probabletranscriptional activator of thiaminebiosynthetic genes 0.210.81748&radic&radic&radic&radic S000002772CDC40YDR364CverifiedPre-mRNA splicing factor, important for catalytic step II ofpre-mRNA splicing and plays a role in cellcycle progression; required for DNA synthesisduring mitosis and meiosis; has WD repeats 0.208710.8173&radic&radic&radic&radic&radic&radic S000005871TYE7YOR344CverifiedSerine-rich protein that contains a basic-helix-loop-helix(bHLH) DNA binding motif; binds E-boxes ofglycolytic genes and contributes to theiractivation; may function as a transcriptionalactivator in Ty1-mediated gene expression &radic0.207930.8172&radic&radic&radic&radic&radic S000001933RSC8YFR037CverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; essential for viability andmitotic growth; homolog of SWI/SNF subunitSwi3p, but unlike Swi3p, does not activatetranscription of reporters 0.208490.8172&radic&radic&radic&radic&radic S000001891MSH4YFL003CverifiedProtein involved in meiotic recombination, required for normallevels of crossing over, colocalizes with Zip2pto discrete foci on meiotic chromosomes, hashomology to bacterial MutS protein &radic0.20650.81527 S000004264CDC46YLR274WverifiedComponent of the hexameric MCM complex, which is important forpriming origins of DNA replication in G1 andbecomes an active ATP-dependent helicase thatpromotes DNA melting and elongation whenactivated by Cdc7p-Dbf4p in S-phase 0.206340.81525&radic&radic&radic S000000611SRD1YCR018CverifiedProtein involved in the processing of pre-rRNA to mature rRNA;contains a C2/C2 zinc finger motif; srd1mutation suppresses defects caused by therrp1-1 mutation 0.205770.81515&radic&radic S000005429HST1YOL068CverifiedNAD(+)-dependent histone deacetylase; essential subunit of theSum1p/Rfm1p/Hst1p complex required forORC-dependent silencing and mitotic repression;non-essential subunit of the Set3C deacetylasecomplex; involved in telomere maintenance 0.2040.81414&radic&radic&radic S000000065RFA1YAR007CverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination &radic0.200740.81307&radic&radic&radic S000002767VID21YDR359CverifiedComponent of the NuA4 histone acetyltransferase complex 0.200080.81235&radic&radic&radic&radic S000001705YKL222CUncharacterizedPutative protein of unknown function; similar to transcriptional regulators from the zinc cluster (binuclear cluster) protein family; null mutant is sensitive to caffeine 0.19930.81095&radic S000004434SIR3YLR442CverifiedSilencing protein that interacts with Sir2p and Sir4p, andhistone H3 and H4 tails, to establish atranscriptionally silent chromatin state;required for spreading of silenced chromatin;recruited to chromatin through interaction withRap1p 0.19910.81093 S000001162MSH1YHR120WverifiedDNA-binding protein of the mitochondria involved in repair ofmitochondrial DNA, has ATPase activity andbinds to DNA mismatches; has homology to E.coli MutS; transcription is induced duringmeiosis &radic0.199090.81093&radic&radic&radic&radic S000003908HMS2YJR147WverifiedProtein with similarity to heat shock transcription factors;overexpression suppresses the pseudohyphalfilamentation defect of a diploid mep1 mep2homozygous null mutant 0.197890.81022&radic&radic&radic&radic S000001298CST6YIL036WverifiedBasic leucine zipper (bZIP) transcription factor of theATF/CREB family, activates transcription ofgenes involved in utilization of non-optimalcarbon sources; involved in telomeremaintenance 0.197130.80967&radic&radic&radic S000004621STB4YMR019WverifiedProtein that binds Sin3p in a two-hybrid assay; contains aZn(II)2Cys6 zinc finger domain characteristicof DNA-binding proteins &radic0.196010.80945&radic&radic&radic&radic S000004395SFP1YLR403WverifiedTranscription factor that controls expression of many ribosomebiogenesis genes in response to nutrients andstress, regulates G2/M transitions duringmitotic cell cycle and DNA-damage response,involved in cell size modulation &radic0.195430.80945&radic&radic&radic S000001441MPH1YIR002CverifiedMember of the DEAH family of helicases, functions in anerror-free DNA damage bypass pathway thatinvolves homologous recombination, mutationsconfer a mutator phenotype 0.19510.80927&radic&radic S000000971RPH1YER169WverifiedTranscriptional repressor of PHR1, which is a photolyaseinduced by DNA damage; binds to AG(4) (C(4)T)sequence upstream of PHR1; Rph1pphosphorylation during DNA damage is undercontrol of the MEC1-RAD53 pathway 0.194720.80909&radic S000003038RPB9YGL070CverifiedRNA polymerase II subunit B12.6; contacts DNA; mutations affecttranscription start site; involved in telomeremaintenance 0.194680.80897&radic&radic&radic S000003520MAL13YGR288WverifiedMAL-activator protein, part of complex locus MAL1;nonfunctional in genomic reference strain S288C &radic0.193880.80868&radic&radic&radic&radic S000003177MIG2YGL209WverifiedProtein containing zinc fingers, involved in repression, alongwith Mig1p, of SUC2 (invertase) expression byhigh levels of glucose; binds to Mig1p-bindingsites in SUC2 promoter 0.194280.80868&radic&radic&radic&radic&radic&radic S000004443LEU3YLR451WverifiedZinc-finger transcription factor that regulates genes involvedin branched chain amino acid biosynthesis andammonia assimilation; positively regulated byalpha-isopropylmalate, an intermediate inleucine biosynthesis 0.194060.80868&radic&radic&radic&radic&radic S000005959MET31YPL038WverifiedZinc-finger DNA-binding protein, involved in regulatingexpression of the methionine biosyntheticgenes, similar to Met32p &radic0.193180.80839&radic&radic&radic&radic&radic&radic&radic S000001498PUT3YKL015WverifiedTranscriptional activator of proline utilization genes,constitutively binds PUT1 and PUT2 promotersequences and undergoes a conformational changeto form the active state; has a Zn(2)-Cys(6)binuclear cluster domain 0.190460.80698&radic&radic&radic&radic S000002503GIS1YDR096WverifiedTranscriptional factor, involved in the expression of genesduring nutrient limitation; also involved inthe negative regulation of DPP1 and PHR1 &radic0.189910.80603&radic&radic&radic&radic&radic S000001515IXR1YKL032CverifiedProtein that binds DNA containing intrastrand cross-linksformed by cisplatin, contains two HMG (highmobility group box) domains, which confer theability to bend cisplatin-modified DNA;mediates aerobic transcriptional repression ofCOX5b &radic0.189540.80569&radic&radic&radic S000006098CUP9YPL177CverifiedHomeodomain-containing transcriptional repressor of PTR2, whichencodes a major peptide transporter; importedpeptides activate ubiquitin-dependentproteolysis, resulting in degradation of Cup9pand de-repression of PTR2 transcription 0.189220.80552&radic&radic&radic&radic S000004166RFX1YLR176CverifiedProtein involved in DNA damage and replication checkpointpathway; recruits repressors Tup1p and Cyc8p topromoters of DNA damage-inducible genes;similar to a family of mammalian DNA bindingRFX1-4 proteins 0.188940.80424&radic&radic&radic&radic&radic&radic S000002835RPN9YDR427WverifiedNon-ATPase regulatory subunit of the 26S proteasome, hassimilarity to putative proteasomal subunits inother species; null mutant is temperaturesensitive and exhibits cell cycle andproteasome assembly defects 0.188030.80329&radic&radic S000000703RDS1YCR106WverifiedZinc cluster protein involved in conferring resistance tocycloheximide &radic0.188120.80329&radic&radic&radic&radic&radic S000006269ROX1YPR065WverifiedHeme-dependent repressor of hypoxic genes; contains an HMGdomain that is responsible for DNA bendingactivity &radic0.187860.80252&radic S000000918SLX8YER116CverifiedProtein containing a RING finger domain that interacts withHex3p; mutant phenotypes and geneticinteractions suggest a role in sumoylation andin genome stability 0.187290.8012&radic&radic S000004218ECM22YLR228CverifiedSterol regulatory element binding protein, regulatestranscription of the sterol biosynthetic genesERG2 and ERG3; member of the fungus-specificZn[2]-Cys[6] binuclear cluster family oftranscription factors; homologous to Upc2p 0.187150.8012&radic&radic&radic&radic&radic S000005743RFC1YOR217WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon &radic0.186740.8012&radic&radic S000004744GAT2YMR136WverifiedProtein containing GATA family zinc finger motifs; similar toGln3p and Dal80p; expression repressed byleucine &radic0.186450.80087&radic&radic S000005206POL2YNL262WverifiedCatalytic subunit of DNA polymerase epsilon, one of the majorchromosomal DNA replication polymerasescharacterized by processivity and proofreadingexonuclease activity; also involved in DNAsynthesis during DNA repair 0.186310.80076&radic&radic&radic&radic S000005770ESA1YOR244WverifiedHistone acetyltransferase catalytic subunit of the nativemultisubunit complex (NuA4) that acetylatesfour conserved internal lysines of histone H4N-terminal tail; required for cell cycleprogression 0.185840.80021&radic&radic S000004064BUD20YLR074CverifiedProtein involved in bud-site selection; diploid mutants displaya random budding pattern instead of thewild-type bipolar pattern 0.185110.79983&radic&radic&radic&radic&radic S000001807BAS1YKR099WverifiedMyb-related transcription factor involved in regulating basaland induced expression of genes of the purineand histidine biosynthesis pathways 0.184520.79793&radic S000003977YLL054CUncharacterizedPutative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene 0.183860.796&radic&radic&radic&radic S000003651ASF1YJL115WverifiedNucleosome assembly factor, involved in chromatin assembly anddisassembly, anti-silencing protein that causesderepression of silent loci when overexpressed 0.182530.7959&radic&radic&radic S000000406CDC47YBR202WverifiedComponent of the hexameric MCM complex, which is important forpriming origins of DNA replication in G1 andbecomes an active ATP-dependent helicase thatpromotes DNA melting and elongation whenactivated by Cdc7p-Dbf4p in S-phase 0.181940.79478&radic&radic&radic&radic&radic&radic S000001456MET28YIR017CverifiedTranscriptional activator in the Cbf1p-Met4p-Met28p complex,participates in the regulation of sulfurmetabolism &radic0.181350.79446&radic&radic S000002217RAD59YDL059CverifiedProtein involved in the repair of double-strand breaks in DNAduring vegetative growth via recombination andsingle-strand annealing; anneals complementarysingle-stranded DNA; homologous to Rad52p &radic0.181040.79441&radic&radic&radic&radic S000005922HAT1YPL001WverifiedCatalytic subunit of the Hat1p-Hat2p histone acetyltransferasecomplex that uses the cofactor acetyl coenzymeA, to acetylate free nuclear and cytoplasmichistone H4; involved in telomeric silencing andDNA double-strand break repair 0.179450.79246&radic&radic&radic&radic S000000692HMRA2YCR096CverifiedSilenced copy of a2 at HMR; similarity to Alpha2p; requiredalong with a1p for inhibiting expression of theHO endonuclease in a/alpha HO/HO diploid cellswith an active mating-type interconversionsystem 0.177990.79137&radic&radic S000001521RGT1YKL038WverifiedGlucose-responsive transcription factor that regulatesexpression of several glucose transporter (HXT)genes in response to glucose; binds topromoters and acts both as a transcriptionalactivator and repressor &radic0.177310.79043&radic&radic&radic&radic&radic&radic&radic&radic S000004349RSC2YLR357WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; involvedin telomere maintenance 0.177570.79043&radic&radic S000005047MET4YNL103WverifiedLecine-zipper transcriptional activator, responsible for theregulation of the sulfur amino acid pathway,requires different combinations of theauxiliary factors Cbf1p, Met28p, Met31p andMet32p 0.175940.78875&radic&radic&radic S000005688YRR1YOR162CverifiedZn2-Cys6 zinc-finger transcription factor that activates genesinvolved in multidrug resistance; paralog ofYrm1p, acting on an overlapping set of targetgenes 0.176450.78875&radic&radic&radic&radic&radic&radic&radic&radic S000000148SAS3YBL052CverifiedHistone acetyltransferase catalytic subunit of NuA3 complexthat acetylates histone H3, involved intranscriptional silencing; homolog of themammalian MOZ proto-oncogene; sas3 gcn5 doublemutation confers lethality 0.175590.78795&radic&radic&radic&radic&radic S000005864TEA1YOR337WverifiedTy1 enhancer activator required for full levels of Tyenhancer-mediated transcription; C6 zinccluster DNA-binding protein &radic0.175460.78795&radic&radic&radic&radic S000000661HCM1YCR065WverifiedForkhead transcription factor that drives S-phase specificexpression of genes involved in chromosomesegregation, spindle dynamics, and budding;suppressor of calmodulin mutants with specificSPB assembly defects; telomere maintenance role &radic0.174670.78667&radic&radic S000005083RLR1YNL139CverifiedSubunit of the THO complex, which is required for efficienttranscription elongation and involved intranscriptional elongation-associatedrecombination; required for LacZ RNA expressionfrom certain plasmids &radic0.17270.78343&radic&radic S000000830MIG3YER028CverifiedProbable transcriptional repressor involved in response totoxic agents such as hydroxyurea that inhibitribonucleotide reductase; phosphorylation bySnf1p or the Mec1p pathway inactivates Mig3p,allowing induction of damage response genes &radic0.171020.78307&radic&radic&radic&radic&radic S000006366ORC4YPR162CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing &radic0.171330.78307&radic&radic&radic&radic&radic S000004088CHA4YLR098CverifiedDNA binding transcriptional activator, mediatesserine/threonine activation of the catabolicL-serine (L-threonine) deaminase (CHA1);Zinc-finger protein with Zn[2]-Cys[6]fungal-type binuclear cluster domain &radic0.17050.78292&radic&radic&radic&radic&radic&radic S000000735GCN4YEL009CverifiedTranscriptional activator of amino acid biosynthetic genes inresponse to amino acid starvation; expressionis tightly regulated at both thetranscriptional and translational levels &radic0.170590.78292&radic&radic&radic&radic&radic S000004375SMC6YLR383WverifiedProtein involved in structural maintenance of chromosomes;essential subunit of Mms21-Smc5-Smc6 complex;required for growth, DNA repair,interchromosomal and sister chromatidrecombination; homologous to S. pombe rad18 0.168220.78146&radic&radic S000004225YLR235CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TOP3 0.167960.78103&radic&radic S000001842YFL052WUncharacterizedPutative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity &radic0.167870.78045&radic&radic S000001452GAT4YIR013CverifiedProtein containing GATA family zinc finger motifs &radic0.167470.78045 S000003709RFA3YJL173CverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination &radic0.167110.77934&radic&radic&radic S000003796RAD26YJR035WverifiedProtein involved in transcription-coupled repair nucleotideexcision repair of UV-induced DNA lesions;homolog of human CSB protein 0.16660.77743&radic&radic S000006226YPR022CUncharacterizedHypothetical protein 0.166330.77743&radic&radic S000003625SIP4YJL089WverifiedC6 zinc cluster transcriptional activator that binds to thecarbon source-responsive element (CSRE) ofgluconeogenic genes; involved in the positiveregulation of gluconeogenesis; regulated bySnf1p protein kinase; localized to the nucleus 0.164220.77491 S000001207DNA2YHR164CverifiedEssential tripartite DNA replication factor withsingle-stranded DNA-dependent ATPase,ATP-dependent nuclease, and helicaseactivities; required for Okazaki fragmentprocessing; involved in DNA repair pathways;potential Cdc28p substrate 0.164020.77491&radic&radic&radic&radic&radic S000004268YLR278CUncharacterizedZinc-cluster protein; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; YLR278C is not an essential gene 0.163770.77396&radic S000000253REB1YBR049CverifiedRNA polymerase I enhancer binding protein; DNA binding proteinwhich binds to genes transcribed by both RNApolymerase I and RNA polymerase II; requiredfor termination of RNA polymerase Itranscription 0.162910.77369&radic&radic S000007223LUG1YCR087C-AuncharacterizedPutative protein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to thenucleolus; YCR087C-A is not an essential gene 0.161520.77197 S000002621UPC2YDR213WverifiedSterol regulatory element binding protein, inducestranscription of sterol transport andbiosynthetic genes; involved in the anaerobicinduction of DAN/TIR mannoproteins andseripauperins; binucleate zinc cluster protein;Ecm22p homolog 0.161870.77197&radic&radic&radic&radic S000004004PPR1YLR014CverifiedZinc finger transcription factor containing a Zn(2)-Cys(6)binuclear cluster domain, positively regulatestranscription of genes involved in uracilbiosynthesis; activity may be modulated byinteraction with Tup1p &radic0.161030.77197&radic&radic&radic S000002840NPL3YDR432WverifiedRNA-binding protein that carries poly(A)+ mRNA from the nucleusinto the cytoplasm; phosphorylation by Sky1p inthe cytoplasm may promote release of mRNAs 0.16060.77092&radic&radic&radic&radic&radic&radic&radic&radic S000002344TFP1YDL185WverifiedVacuolar ATPase V1 domain subunit A containing the catalyticnucleotide binding sites; protein precursorundergoes self-catalyzed splicing to yield theextein Tfp1p and the intein Vde (PI-SceI),which is a site-specific endonuclease 0.160580.77092&radic&radic S000003730CDC6YJL194WverifiedEssential ATP-binding protein required for DNA replication,component of the pre-replicative complex(pre-RC) which requires ORC to associate withchromatin and is in turn required for Mcm2-7pDNA association; homologous to S. pombe Cdc18p &radic0.160190.7709&radic&radic&radic&radic&radic S000005160RAP1YNL216WverifiedDNA-binding protein involved in either activation or repressionof transcription, depending on binding sitecontext; also binds telomere sequences andplays a role in telomeric position effect(silencing) and telomere structure &radic0.160170.77&radic&radic&radic&radic&radic&radic S000006217YPR013CUncharacterizedPutative zinc finger protein; YPR013C is not an essential gene 0.160050.77&radic S000003592ZAP1YJL056CverifiedZinc-regulated transcription factor, binds to zinc-responsivepromoter elements to induce transcription ofcertain genes in the presence of zinc;regulates its own transcription; contains sevenzinc-finger domains &radic0.158960.76716&radic&radic S000004734SAS2YMR127CverifiedHistone acetyltransferase (HAT) catalytic subunit of the SAScomplex (Sas2p-Sas4p-Sas5p), which acetylatesfree histones and nucleosomes and regulatestranscriptional silencing; member of theMYSTacetyltransferase family 0.158560.76716&radic&radic&radic S000001048STP2YHR006WverifiedTranscription factor, activated by proteolytic processing inresponse to signals from the SPS sensor systemfor external amino acids; activatestranscription of amino acid permease genes 0.15870.76716&radic&radic&radic S000002178RPN4YDL020CverifiedTranscription factor that stimulates expression of proteasomegenes; Rpn4p levels are in turn regulated bythe 26S proteasome in a negative feedbackcontrol mechanism; RPN4 is transcriptionallyregulated by various stress responses &radic0.157780.76694&radic&radic S000004224TOP3YLR234WverifiedDNA Topoisomerase III, conserved protein that functions in acomplex with Sgs1p and Rmi1p to relaxsingle-stranded negatively-supercoiled DNApreferentially, involved in telomere stabilityand regulation of mitotic recombination &radic0.157250.76686&radic&radic&radic&radic&radic&radic S000000662RAD18YCR066WverifiedProtein involved in postreplication repair; bindssingle-stranded DNA and has single-stranded DNAdependent ATPase activity; forms heterodimerwith Rad6p; contains RING-finger motif &radic0.156430.76576&radic S000005558HMS1YOR032CverifiedBasic helix-loop-helix (bHLH) protein with similarity tomyc-family transcription factors;overexpression confers hyperfilamentous growthand suppresses the pseudohyphal filamentationdefect of a diploid mep1 mep2 homozygous nullmutant &radic0.155770.7648&radic&radic&radic&radic S000000264ORC2YBR060CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing; may be phosphorylated by Cdc28p &radic0.155060.76304&radic&radic S000004256PDR8YLR266CverifiedTranscription factor; targets include ATP-binding cassette(ABC) transporters, major facilitatorsuperfamily transporters, and other genesinvolved in the pleiotropic drug resistance(PDR) phenomenon &radic0.153740.76065&radic&radic&radic&radic&radic S000000501MAL33YBR297WverifiedMAL-activator protein, part of complex locus MAL3;nonfunctional in genomic reference strain S288C &radic0.153610.76065 S000004093CDC45YLR103CverifiedDNA replication initiation factor; recruited to MCM pre-RCcomplexes at replication origins; promotesrelease of MCM from Mcm10p, recruits elongationmachinery; mutants in human homolog may causevelocardiofacial and DiGeorge syndromes &radic0.154760.76065&radic&radic&radic&radic&radic S000000302MMS4YBR098WverifiedSubunit of the structure-specific Mms4p-Mus81p endonucleasethat cleaves branched DNA; involved inrecombination and DNA repair 0.154470.76065&radic&radic&radic S000005907RDR1YOR380WverifiedTranscriptional repressor involved in the control of multidrugresistance; negatively regulates expression ofthe PDR5 gene; member of the Gal4p family ofzinc cluster proteins &radic0.153480.75947&radic&radic&radic S000002315YDL156WUncharacterizedHypothetical protein 0.153210.75947&radic&radic&radic S000004546YML081WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YML081w is not an essential gene 0.15340.75947&radic S000002829ARO80YDR421WverifiedZinc finger transcriptional activator of the Zn2Cys6 family;activates transcription of aromatic amino acidcatabolic genes in the presence of aromaticamino acids 0.153190.75947&radic&radic&radic S000005831ISW2YOR304WverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPasecomponent that, with Itc1p, forms a complexrequired for repression of a-specific genes,INO1, and early meiotic genes during mitoticgrowth 0.151160.75806&radic&radic S000000443YBR239CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR239C is not an essential gene 0.150760.75739&radic&radic&radic S000002578HSP42YDR171WverifiedSmall cytosolic stress-induced chaperone that formsbarrel-shaped oligomers and suppresses theaggregation of non-native proteins; oligomerdissociation is not required for function;involved in cytoskeleton reorganization afterheat shock 0.150.755&radic&radic&radic&radic&radic S000004742GID8YMR135CverifiedProtein of unknown function, involved in proteasome-dependentcatabolite inactivation offructose-1,6-bisphosphatase; contains LisH andCTLH domains, like Vid30p; dosage-dependentregulator of START 0.149880.755&radic&radic&radic S000004541WAR1YML076CverifiedHomodimeric Zn2Cys6 zinc finger transcription factor; binds toa weak acid response element to inducetranscription of PDR12 and FUN34, encoding anacid transporter and a putative ammoniatransporter, respectively &radic0.149610.75452&radic S000006379DPB2YPR175WverifiedSecond largest subunit of DNA polymerase II (DNA polymeraseepsilon), required for normal yeast chromosomalreplication; expression peaks at the G1/S phaseboundary; potential Cdc28p substrate 0.149390.75421&radic&radic&radic&radic S000004006PML1YLR016CverifiedSubunit of the RES complex, which is required for nuclearretention of unspliced pre-mRNAs; acts in thesame pathway as Pml39p and Mlp1p 0.148850.75276&radic&radic&radic&radic&radic&radic S000006219YPR015CUncharacterizedPutative protein of unknown function 0.148760.75276&radic&radic S000001160ORC6YHR118CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing; may be phosphorylated by Cdc28p &radic0.148050.75233&radic&radic&radic&radic&radic S000000340MEC1YBR136WverifiedGenome integrity checkpoint protein and PI kinase superfamilymember; signal transducer required for cellcycle arrest and transcriptional responsesprompted by damaged or unreplicated DNA;monitors and participates in meioticrecombination 0.148080.75233 S000005346YNR063WUncharacterizedHypothetical protein 0.147530.75041&radic S000003299YGR067CUncharacterizedPutative protein of unknown function; contains a zinc finger motif similar to that of Adr1p 0.147350.75041&radic&radic&radic&radic&radic S000001863HAC1YFL031WverifiedbZIP transcription factor (ATF/CREB1 homolog) that regulatesthe unfolded protein response, via UPREbinding, and membrane biogenesis; ERstress-induced splicing pathway utilizingIre1p, Trl1p and Ada5p facilitates efficientHac1p synthesis &radic0.147150.75041&radic&radic&radic&radic S000001457YAP5YIR018WverifiedBasic leucine zipper (bZIP) transcription factor 0.146680.74952&radic&radic&radic&radic&radic S000001772OAF3YKR064WuncharacterizedZinc cluster protein of unknown function; the authentic,non-tagged protein is detected in highlypurified mitochondria in high-throughputstudies 0.146990.74952&radic&radic&radic S000004121ACE2YLR131CverifiedTranscription factor that activates expression of earlyG1-specific genes, localizes to daughter cellnuclei after cytokinesis and delays G1progression in daughters, localization isregulated by phosphorylation; potential Cdc28psubstrate 0.146310.74869&radic&radic&radic&radic&radic&radic&radic S000002441LYS14YDR034CverifiedTranscriptional activator involved in regulation of genes ofthe lysine biosynthesis pathway; requires2-aminoadipate semialdehyde as co-inducer 0.145290.74828&radic&radic S000006339CTF4YPR135WverifiedChromatin-associated protein, required for sister chromatidcohesion; interacts with DNA polymerase alpha(Pol1p) and may link DNA synthesis to sisterchromatid cohesion &radic0.143860.74698&radic&radic&radic&radic&radic S000003049YGL081WUncharacterizedHypothetical protein 0.143460.7464 S000001886SMC1YFL008WverifiedSubunit of the multiprotein cohesin complex, essential proteininvolved in chromosome segregation and indouble-strand DNA break repair; SMC chromosomalATPase family member, binds DNA with apreference for DNA with secondary structure &radic0.143360.7464&radic&radic&radic&radic&radic&radic S000002450NRG1YDR043CverifiedTranscriptional repressor that recruits the Cyc8p-Tup1p complexto promoters; mediates glucose repression andnegatively regulates a variety of processesincluding filamentous growth and alkaline pHresponse &radic0.141820.74402&radic&radic&radic S000000986YER184CUncharacterizedHypothetical protein 0.14140.74373 S000001392ASG1YIL130WuncharacterizedProposed transcriptional activator, member of the Gal4p familyof zinc cluster proteins 0.140590.74264&radic S000005171JJJ1YNL227CverifiedProtein that contains a 70 amino acid J-domain, may function asa co-chaperone to recruit Hsp70-like activityto specific sites; mutation causes defects influid-phase endocytosis 0.140570.74264&radic&radic&radic S000001234CTF8YHR191CverifiedSubunit of a complex with Ctf18p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion 0.140460.74253 S000000237EDS1YBR033WuncharacterizedNon-essential protein of unknown function 0.140010.74179 S000005335POP2YNR052CverifiedRNase of the DEDD superfamily, subunit of the Ccr4-Not complexthat mediates 3' to 5' mRNA deadenylation 0.140170.74179&radic&radic&radic&radic S000002722RAD34YDR314CverifiedProtein involved in nucleotide excision repair (NER);homologous to RAD4 0.140280.74179&radic&radic&radic&radic&radic S000005394SMC5YOL034WverifiedStructural maintenance of chromosomes (SMC) protein; essentialsubunit of the Mms21-Smc5-Smc6 complex;required for growth and DNA repair; S. pombehomolog forms a heterodimer with S. pombeRad18p that is involved in DNA repair 0.139760.73995&radic&radic&radic&radic S000001356LYS12YIL094CverifiedHomo-isocitrate dehydrogenase, an NAD-linked mitochondrialenzyme required for the fourth step in thebiosynthesis of lysine, in whichhomo-isocitrate is oxidatively decarboxylatedto alpha-ketoadipate 0.139790.73995 S000003169MCM6YGL201CverifiedProtein involved in DNA replication; component of the Mcm2-7hexameric complex that binds chromatin as apart of the pre-replicative complex 0.139320.73781&radic&radic&radic S000002794MUS81YDR386WverifiedHelix-hairpin-helix protein, involved in DNA repair andreplication fork stability; functions as anendonuclease in complex with Mms4p; interactswith Rad54p 0.139270.73781&radic&radic&radic S000006085MLH3YPL164CverifiedProtein involved in DNA mismatch repair; forms a complex withMlh1p to promote meiotic crossing-over;mammalian homolog is implicated mammalianmicrosatellite instability 0.137480.73477&radic&radic S000002928YDR520CUncharacterizedHypothetical protein 0.137870.73477&radic&radic&radic S000004391BDF1YLR399CverifiedProtein involved in transcription initiation at TATA-containingpromoters; associates with the basaltranscription factor TFIID; contains twobromodomains; corresponds to the C-terminalregion of mammalian TAF1; redundant with Bdf2p 0.137960.73477&radic&radic&radic&radic&radic&radic S000005060DMA2YNL116WverifiedProtein involved in regulating spindle position andorientation, functionally redundant with Dma1p;homolog of S. pombe Dma1 and H. sapiens Chfr 0.137170.73383&radic&radic S000001014SPO11YHL022CverifiedMeiosis-specific protein that initiates meiotic recombinationby catalyzing the formation of double-strandbreaks in DNA via a transesterificationreaction; required for homologous chromosomepairing and synaptonemal complex formation 0.137180.73383&radic&radic&radic S000001401REV7YIL139CverifiedProcessivity subunit of DNA polymerase zeta, which is involvedin DNA repair and translesion synthesis;required for mutagenesis induced by DNA damage 0.136440.73263 S000006054RDS2YPL133CverifiedZinc cluster protein involved in conferring resistance toketoconazole &radic0.136310.73263&radic&radic S000001462DAL81YIR023WverifiedPositive regulator of genes in multiple nitrogen degradationpathways; contains DNA binding domain but doesnot appear to bind the dodecanucleotidesequence present in the promoter region of manygenes involved in allantoin catabolism 0.135480.73081&radic&radic&radic S000003888RSF2YJR127CverifiedZinc-finger protein involved in transcriptional control of bothnuclear and mitochondrial genes, many of whichspecify products required for glycerol-basedgrowth, respiration, and other functions &radic0.135860.73081&radic S000003674TIF2YJL138CverifiedTranslation initiation factor eIF4A, identical to Tif1p;DEA(D/H)-box RNA helicase that couples ATPaseactivity to RNA binding and unwinding; forms adumbbell structure of two compact domainsconnected by a linker; interacts with eIF4G 0.134470.72912&radic&radic&radic S000003741YJL206CUncharacterizedPutative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment 0.134240.72803 S000004367STP3YLR375WuncharacterizedZinc-finger protein of unknown function, possibly involved inpre-tRNA splicing and in uptake ofbranched-chain amino acids 0.132140.72669&radic&radic&radic&radic S000004794RGM1YMR182CverifiedPutative transcriptional repressor with proline-rich zincfingers; overproduction impairs cell growth 0.131180.7253&radic&radic&radic&radic&radic&radic S000005508SPT20YOL148CverifiedSubunit of the SAGA transcriptional regulatory complex,involved in maintaining the integrity of thecomplex 0.131040.7253&radic&radic S000006003MOT1YPL082CverifiedEssential abundant protein involved in regulation oftranscription, removes Spt15p (TBP) from DNAvia its C-terminal ATPase activity, forms acomplex with TBP that binds TATA DNA with highaffinity but with altered specificity 0.131170.7253&radic&radic&radic&radic&radic S000006390PZF1YPR186CverifiedTranscription factor IIIA (TFIIIA), essential protein with nineC2H2 Zn-fingers, binds the 5S rRNA gene throughthe zinc finger domain and directs assembly ofa multiprotein initiation complex for RNApolymerase III; also binds DNA 0.130850.72406&radic&radic&radic&radic&radic&radic S000000629SNT1YCR033WverifiedSubunit of the Set3C deacetylase complex that interactsdirectly with the Set3C subunit, Sif2p;putative DNA-binding protein 0.130520.72406&radic&radic S000005217TOF1YNL273WverifiedSubunit of a replication-pausing checkpoint complex(Tof1p-Mrc1p-Csm3p) that acts at the stalledreplication fork to promote sister chromatidcohesion after DNA damage, facilitating gaprepair of damaged DNA; interacts with the MCMhelicase 0.129820.72386&radic&radic S000004003GAT3YLR013WverifiedProtein containing GATA family zinc finger motifs &radic0.129720.72328&radic&radic S000004966HDA1YNL021WverifiedPutative catalytic subunit of a class II histone deacetylasecomplex that also contains Hda2p and Hda3p;Hda1p interacts with the Hda2p-Hda3p subcomplexto form an active tetramer; deletion increaseshistone H2B, H3 and H4 acetylation 0.129140.72059&radic&radic&radic S000005873REV1YOR346WverifiedDeoxycytidyl transferase, forms a complex with the subunits ofDNA polymerase zeta, Rev3p and Rev7p; involvedin repair of abasic sites in damaged DNA 0.128580.72059&radic&radic&radic&radic&radic S000000449ISW1YBR245CverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPase thatforms a complex with Ioc2p and Ioc4p toregulate transcription elongation, and acomplex with Ioc3p to repress transcriptioninitiation 0.129710.72059&radic&radic&radic&radic&radic S000003927ORC3YLL004WverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing &radic0.128340.7205&radic&radic&radic S000004466YAP1YML007WverifiedBasic leucine zipper (bZIP) transcription factor required foroxidative stress tolerance; mediatespleiotropic drug and metal resistance;localized to the nucleus in response to thepresence of oxidants &radic0.127670.71978&radic&radic&radic&radic&radic&radic&radic&radic S000006049TBF1YPL128CverifiedTelobox-containing general regulatory factor; binds to TTAGGGrepeats within subtelomeric anti-silencingregions (STARs) and possibly throughout thegenome and mediates their insulating capacityby blocking silent chromatin propagation &radic0.126770.71932&radic&radic&radic&radic&radic S000003131RAD54YGL163CverifiedDNA-dependent ATPase, stimulates strand exchange by modifyingthe topology of double-stranded DNA; involvedin the recombinational repair of double-strandbreaks in DNA during vegetative growth andmeiosis; member of the SWI/SNF family &radic0.126470.71932&radic&radic S000004847RNH1YMR234WverifiedRibonuclease H1, removes RNA primers during Okazaki fragmentsynthesis; degrades RNA attached to the 5'-endof a DNA strand 0.125630.71807&radic&radic&radic&radic&radic S000005046POL1YNL102WverifiedCatalytic subunit of the DNA polymerase alpha-primase complex,required for the initiation of DNA replicationduring mitotic DNA synthesis and premeiotic DNAsynthesis 0.125760.71807&radic&radic&radic&radic S000003639GSM1YJL103CuncharacterizedPutative zinc cluster protein of unknown function; proposed tobe involved in the regulation of energymetabolism, based on patterns of expression andsequence analysis &radic0.125050.71782&radic&radic S000003484GCN5YGR252WverifiedHistone acetyltransferase, acetylates N-terminal lysines onhistones H2B and H3; catalytic subunit of theADA and SAGA histone acetyltransferasecomplexes; founding member of the Gcn5p-relatedN-acetyltransferase superfamily 0.123880.71491&radic&radic S000001388STH1YIL126WverifiedATPase component of the ATP-dependent RSC chromatin remodelingcomplex required for kinetochore function inchromosome segregation; required for expressionof early meiotic genes; essentialhelicase-related protein homologous to Snf2p 0.124440.71491&radic&radic S000005449HAL9YOL089CverifiedPutative transcription factor containing a zinc finger;overexpression increases salt tolerance throughincreased expression of the ENA1 (Na+/Li+extrusion pump) gene while gene disruptiondecreases both salt tolerance and ENA1expression 0.12260.71391&radic&radic S000000966CHD1YER164WverifiedNucleosome remodeling factor that functions in regulation oftranscription elongation; contains a chromodomain, a helicase domain and a DNA-bindingdomain; component of both the SAGA and SILKcomplexes 0.122190.71328&radic S000002329UGA3YDL170WverifiedTranscriptional activator necessary for gamma-aminobutyrate(GABA)-dependent induction of GABA genes (suchas UGA1, UGA2, UGA4); zinc-finger transcriptionfactor of the Zn(2)-Cys(6) binuclear clusterdomain type; localized to the nucleus &radic0.12140.71222&radic&radic&radic S000003118INO80YGL150CverifiedATPase that forms a large complex, containing actin and severalactin-related proteins, that has chromatinremodeling activity and 3' to 5' DNA helicaseactivity in vitro; shows similarity to theSnf2p family of ATPases 0.119720.70997&radic S000003223FZF1YGL254WverifiedTranscription factor involved in sulfite metabolism, soleidentified regulatory target is SSU1,overexpression suppresses sulfite-sensitivityof many unrelated mutants due tohyperactivation of SSU1, contains five zincfingers &radic0.119550.70972&radic&radic&radic&radic&radic S000002703HDA2YDR295CverifiedSubunit of a possibly tetrameric trichostatin A-sensitive classII histone deacetylase complex containing anHda1p homodimer and an Hda2p-Hda3p heterodimer;involved in telomere maintenance 0.118990.70939&radic&radic&radic S000005943RAD1YPL022WverifiedSingle-stranded DNA endonuclease (with Rad10p), cleavessingle-stranded DNA during nucleotide excisionrepair and double-strand break repair; subunitof Nucleotide Excision Repair Factor 1 (NEF1);homolog of human XPF protein &radic0.11890.70939&radic&radic&radic&radic S000000131POL12YBL035CverifiedB subunit of DNA polymerase alpha-primase complex, required forinitiation of DNA replication during mitoticand premeiotic DNA synthesis; also functions intelomere capping and length regulation 0.118780.70883&radic&radic&radic S000000354TBS1YBR150CverifiedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.118820.70883&radic&radic S000002262QRI7YDL104CuncharacterizedPutative metalloprotease, similar to O-sialoglycoproteinmetallopeptidase from P. haemolytica; theauthentic, non-tagged protein is detected inhighly purified mitochondria in high-throughputstudies 0.118360.70621&radic S000002731PEP7YDR323CverifiedMultivalent adaptor protein that facilitates vesicle-mediatedvacuolar protein sorting by ensuringhigh-fidelity vesicle docking and fusion, whichare essential for targeting of vesicles to theendosome; required for vacuole inheritance 0.118260.70621&radic&radic&radic S000001197RTT107YHR154WverifiedProtein implicated in Mms22-dependent DNA repair during Sphase, DNA damage induces phosphorylation byMec1p at one or more SQ/TQ motifs; interactswith Mms22p and Slx4p; has four BRCT domains;has a role in regulation of Ty1 transposition 0.118450.70621&radic&radic&radic S000001540NUP120YKL057CverifiedSubunit of the Nup84p subcomplex of the nuclear pore complex(NPC), required for even distribution of NPCsaround the nuclear envelope, involved inestablishment of a normal nucleocytoplasmicconcentration gradient of the GTPase Gsp1p 0.117420.70564&radic&radic&radic S000004798HSC82YMR186WverifiedCytoplasmic chaperone of the Hsp90 family, redundant infunction and nearly identical with Hsp82p, andtogether they are essential; expressedconstitutively at 10-fold higher basal levelsthat HSP82 and induced 2-3 fold by heat shock 0.116450.70398&radic&radic&radic&radic&radic&radic S000005162MGS1YNL218WverifiedProtein with DNA-dependent ATPase and ssDNA annealingactivities involved in maintenance of genome;interacts functionally with DNA polymerasedelta; homolog of human Werner helicaseinteracting protein (WHIP) 0.115990.70398&radic&radic&radic&radic&radic&radic&radic S000002718SUM1YDR310CverifiedTranscriptional repressor required for mitotic repression ofmiddle sporulation-specific genes; involved intelomere maintenance, regulated by thepachytene checkpoint 0.115960.70398&radic&radic&radic&radic S000006115DDC1YPL194WverifiedDNA damage checkpoint protein, part of a PCNA-like complexrequired for DNA damage response, required forpachytene checkpoint to inhibit cell cycle inresponse to unrepaired recombinationintermediates; potential Cdc28p substrate 0.115790.70311&radic&radic&radic S000004826CEF1YMR213WverifiedEssential splicing factor; associated with Prp19p and thespliceosome, contains an N-terminal c-Myb DNAbinding motif necessary for cell viability butnot for Prp19p association, evolutionarilyconserved and homologous to S. pombe Cdc5p 0.115660.70273&radic&radic&radic&radic&radic&radic S000006048HHO1YPL127CverifiedHistone H1, a linker histone required for nucleosome packagingat restricted sites; suppresses DNA repairinvolving homologous recombination; notrequired for telomeric silencing, basaltranscriptional repression, or efficientsporulation &radic0.113710.69917&radic&radic&radic&radic&radic S000004368PSY3YLR376CuncharacterizedProtein of unknown function; deletion results in a mutatorphenotype suggesting a role for this protein asa mutational suppressor; deletion increasessensitivity to anticancer drugs oxaliplatin andcisplatin but not mitomycin C 0.112520.69721&radic&radic&radic&radic&radic S000002411RAD57YDR004WverifiedProtein that stimulates strand exchange by stabilizing thebinding of Rad51p to single-stranded DNA;involved in the recombinational repair ofdouble-strand breaks in DNA during vegetativegrowth and meiosis; forms heterodimer withRad55p 0.112050.69689&radic&radic S000000150YBL054WUncharacterizedHypothetical protein 0.11150.696&radic&radic&radic&radic&radic&radic S000000605PGK1YCR012Wverified3-phosphoglycerate kinase, catalyzes transfer of high-energyphosphoryl groups from the acyl phosphate of1,3-bisphosphoglycerate to ADP to produce ATP;key enzyme in glycolysis and gluconeogenesis 0.111440.696&radic&radic&radic&radic&radic S000001157DMA1YHR115CverifiedProtein involved in regulating spindle position andorientation, functionally redundant with Dma2p;homolog of S. pombe Dma1 and H. sapiens Chfr 0.111350.69547&radic&radic S000006151YPL230WUncharacterizedPutative protein of unknown function 0.109450.69229&radic&radic&radic S000004228FAR10YLR238WverifiedProtein involved in G1 cell cycle arrest in response topheromone, in a pathway different from theFar1p-dependent pathway; interacts with Far3p,Far7p, Far8p, Far9p, and Far11p; potentialCdc28p substrate 0.10820.69137&radic S000004837MRE11YMR224CverifiedSubunit of a complex with Rad50p and Xrs2p (RMX complex) thatfunctions in repair of DNA double-strand breaksand in telomere stability, exhibits nucleaseactivity that appears to be required for RMXfunction; widely conserved &radic0.108210.69137&radic&radic&radic&radic&radic&radic&radic S000002488PDC2YDR081CverifiedTranscription factor required for the synthesis of theglycolytic enzyme pyruvate decarboxylase,required for high level expression of both theTHI and the PDC genes 0.10770.69021&radic&radic&radic&radic&radic S000002171HEX3YDL013WverifiedProtein containing a RING finger domain that interacts withSlx8p; mutant phenotypes and geneticinteractions suggest a role in sumoylation andin genome stability 0.10630.68844&radic S000003160IME4YGL192WverifiedProbable mRNA N6-adenosine methyltransferase that is requiredfor IME1 transcript accumulation and forsporulation; expression is induced in starvedMATa/MAT alpha diploid cells 0.106070.68765&radic S000003064TOS8YGL096WverifiedHomeodomain-containing transcription factor; SBF regulatedtarget gene that in turn regulates expressionof genes involved in G1/S phase events such asbud site selection, bud emergence and cellcycle progression; similarity to Cup9p &radic0.105080.68726&radic S000004984BDP1YNL039WverifiedEssential subunit of RNA polymerase III transcription factor(TFIIIB), which is involved in transcription ofgenes encoding tRNAs, 5S rRNA, U6 snRNA, andother small RNAs 0.104460.68574&radic&radic S000003583RTT101YJL047CverifiedCullin subunit of a Roc1p-dependent E3 ubiquitin ligasecomplex; deletion phenotype suggests a role inanaphase progression; interacts with Mms22p andimplicated in Mms22-dependent DNA repair;modified by the ubiquitin-like protein, Rub1p 0.103380.68496&radic&radic S000002330GLT1YDL171CverifiedNAD(+)-dependent glutamate synthase (GOGAT), synthesizesglutamate from glutamine andalpha-ketoglutarate; with Gln1p, forms thesecondary pathway for glutamate biosynthesisfrom ammonia; expression regulated by nitrogensource 0.102950.68439&radic S000005032TOP2YNL088WverifiedEssential type II topoisomerase, relieves torsional strain inDNA by cleaving and re-sealing thephosphodiester backbone of both positively andnegatively supercoiled DNA; cleavescomplementary strands; localizes to axial coresin meiosis &radic0.102280.6831&radic S000003335NOP7YGR103WverifiedNucleolar protein involved in rRNA processing and 60S ribosomalsubunit biogenesis; constituent of severaldifferent pre-ribosomal particles; required forexit from G0 and the initiation ofcell proliferation 0.10160.68192&radic&radic&radic&radic&radic&radic S000003143SAE2YGL175CverifiedProtein with a role in accurate meiotic and mitoticdouble-strand break repair; phosphorylated inresponse to DNA damage and required for normalresistance to DNA-damaging agents 0.101630.68192&radic&radic&radic S000004237IRC20YLR247CuncharacterizedPutative helicase; localized to mitochondria and the nucleus;YLR247C is not an essential gene; null mutantdisplays increased levels of spontaneous Rad52foci 0.101130.68121&radic&radic&radic S000003995SSL1YLR005WverifiedComponent of the core form of RNA polymerase transcriptionfactor TFIIH, which has both protein kinase andDNA-dependent ATPase/helicase activities and isessential for transcription and nucleotideexcision repair; interacts with Tfb4p 0.100660.68009&radic&radic&radic S000002552TAF12YDR145WverifiedSubunit (61/68 kDa) of TFIID and SAGA complexes, involved inRNA polymerase II transcription initiation andin chromatin modification, similar to histoneH2A 0.10080.68009&radic&radic S000003567MAD2YJL030WverifiedComponent of the spindle-assembly checkpoint complex, whichdelays the onset of anaphase in cells withdefects in mitotic spindle assembly; forms acomplex with Mad1p 0.100860.68009&radic&radic&radic S000000890DOT6YER088CverifiedProtein of unknown function, involved in telomeric genesilencing and filamentation 0.099360.67713&radic&radic&radic&radic S000000113PEP1YBL017CverifiedType I transmembrane sorting receptor for multiple vacuolarhydrolases; cycles between the late-Golgi andprevacuolar endosome-like compartments 0.099430.67713&radic&radic&radic&radic&radic S000004339KAP95YLR347CverifiedKaryopherin beta, forms a dimeric complex with Srp1p (Kap60p)that mediates nuclear import of cargo proteinsvia a nuclear localization signal (NLS),interacts with nucleoporins to guide transportacross the nuclear pore complex 0.098560.67713&radic&radic&radic&radic&radic S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.097360.67562&radic&radic&radic&radic&radic&radic&radic S000002348RBS1YDL189WverifiedProtein of unknown function, identified as a high copysuppressor of psk1 psk2 mutations that confertemperature-sensitivity for galactoseutilization; proposed to bind single-strandednucleic acids via its R3H domain 0.097350.67562&radic&radic S000005850PRO2YOR323CverifiedGamma-glutamyl phosphate reductase, catalyzes the second stepin proline biosynthesis 0.096060.67353&radic&radic&radic&radic&radic&radic S000001142YHR100CUncharacterizedPutative protein of unknown function; exhibits growth defect on a non-fermentable (respiratory) carbon source; YHR100C is not an essential gene 0.09660.67353&radic&radic&radic&radic&radic S000005565CKB2YOR039WverifiedBeta' regulatory subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKA2 and CKB1, the many substratesinclude transcription factors and all RNApolymerases 0.095340.67151&radic&radic&radic&radic&radic&radic&radic S000002667YAP6YDR259CverifiedPutative basic leucine zipper (bZIP) transcription factor;overexpression increases sodium and lithiumtolerance 0.095190.67151&radic&radic&radic S000000154SHP1YBL058WverifiedUBX (ubiquitin regulatory X) domain-containing protein thatregulates Glc7p phosphatase activity andinteracts with Cdc48p; interacts withubiquitylated proteins in vivo and is requiredfor degradation of a ubiquitylated modelsubstrate 0.094640.67103&radic&radic&radic&radic&radic&radic&radic S000001596RAD27YKL113Cverified5' to 3' exonuclease, 5' flap endonuclease, required forOkazaki fragment processing and maturation aswell as for long-patch base-excision repair;member of the S. pombe RAD2/FEN1 family 0.09410.67083&radic&radic&radic&radic&radic&radic S000002256SNU23YDL098CverifiedComponent of U4/U6.U5 snRNP involved in mRNA splicing viaspliceosome 0.093940.6697&radic&radic&radic&radic S000002604YDR196CUncharacterizedpredicted to catalyze the final step in synthesis of Coenzyme A 0.093870.6697&radic&radic&radic S000002608VPS64YDR200CverifiedCytoplasmic protein required for cytoplasm to vacuole targetingof proteins; forms a complex with Far3p, Far7p,Far10p, and Far11p that is involved inpheromone-induced cell cycle arrest; alsolocalized to the endoplasmic reticulum membrane 0.092780.66758&radic&radic S000002907LCD1YDR499WverifiedEssential protein required for the DNA integrity checkpointpathways; interacts physically with Mec1p;putative homolog of S. pombe Rad26 and humanATRIP &radic0.092530.66692&radic&radic&radic S000005945RMI1YPL024WverifiedInvolved in response to DNA damage; null mutants have increasedrates of recombination and delayed S phase;interacts physically and genetically with Sgs1p(RecQ family member) and Top3p (topoisomeraseIII) &radic0.092510.66686&radic&radic&radic&radic&radic&radic&radic S000002201PRP11YDL043CverifiedSubunit of the SF3a splicing factor complex, required forspliceosome assembly 0.092420.6664&radic&radic S000005936HST2YPL015CverifiedCytoplasmic member of the silencing information regulator 2(Sir2) family of NAD(+)-dependent proteindeacetylases; modulates nucleolar (rDNA) andtelomeric silencing; possesses NAD(+)-dependenthistone deacetylase activity in vitro 0.092480.6664&radic&radic&radic&radic&radic S000001852YFL042CUncharacterizedPutative protein of unknown function; YFL042C is not an essential gene 0.092360.6662&radic&radic S000000229YBR025CUncharacterizedHypothetical protein 0.091890.66561&radic&radic S000005603RTS2YOR077WverifiedBasic zinc-finger protein, similar to human and mouse Kin17proteins which are chromatin-associatedproteins involved in UV response and DNAreplication 0.091860.66555&radic&radic&radic&radic&radic S000005293CSE2YNR010WverifiedComponent of the Med9/10 module, which is a subcomplex withinthe RNA polymerase II Mediator complex;required for regulation of RNA polymerase IIactivity 0.091330.66405&radic&radic S000006383HDA3YPR179CverifiedSubunit of a possibly tetrameric trichostatin A-sensitive classII histone deacetylase complex that contains anHda1p homodimer and an Hda2p-Hda3p heterodimer;required for the activity of the complex; hassimilarity to Hda2p 0.09090.66062&radic&radic&radic&radic S000001069RPN1YHR027CverifiedNon-ATPase base subunit of the 19S regulatory particle of the26S proteasome; may participate in therecognition of several ligands of theproteasome; contains a leucine-rich repeat(LRR) domain, a site for protein?proteininteractions 0.091140.66062&radic&radic&radic&radic S000004172SWI6YLR182WverifiedTranscription cofactor, forms complexes with DNA-bindingproteins Swi4p and Mbp1p to regulatetranscription at the G1/S transition; involvedin meiotic gene expression; localizationregulated by phosphorylation; potential Cdc28psubstrate 0.090290.66062&radic&radic&radic&radic S000005411GAL11YOL051WverifiedComponent of the Mediator complex; interacts with RNApolymerase II and the general transcriptionfactors to form the RNA polymerase IIholoenzyme; affects transcription by acting astarget of activators and repressors 0.090470.66062&radic&radic&radic S000005554CIN5YOR028CverifiedBasic leucine zipper transcriptional factor of the yAP-1 familythat mediates pleiotropic drug resistance andsalt tolerance; localizes constitutively to thenucleus &radic0.089230.65992&radic&radic&radic&radic&radic&radic&radic S000003905MGM101YJR144WverifiedProtein involved in mitochondrial genome maintenance; componentof the mitochondrial nucleoid, required for therepair of oxidative mtDNA damage &radic0.089420.65992&radic S000005785RPT4YOR259CverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; required for spindlepole body duplication; localized mainly to thenucleus throughout the cell cycle 0.089080.65961&radic&radic&radic&radic&radic&radic&radic S000002384SHS1YDL225WverifiedOne of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p,Shs1p) that form a cortical filamentous collarat the mother-bud neck which is necessary fornormal morphogenesis and cytokinesis 0.089120.65961 S000002483RAD55YDR076WverifiedProtein that stimulates strand exchange by stabilizing thebinding of Rad51p to single-stranded DNA;involved in the recombinational repair ofdouble-strand breaks in DNA during vegetativegrowth and meiosis; forms heterodimer withRad57p 0.089120.65961&radic&radic&radic&radic&radic S000002800SPT3YDR392WverifiedSubunit of the SAGA and SAGA-like transcriptional regulatorycomplexes, interacts with Spt15p to activatetranscription of some RNA polymeraseII-dependent genes, also functions to inhibittranscription at some promoters 0.088480.65903&radic&radic&radic&radic&radic S000005551HST3YOR025WverifiedMember of the Sir2 family of NAD(+)-dependent proteindeacetylases; involved along with Hst4p intelomeric silencing, cell cycle progression,radiation resistance, genomic stability andshort-chain fatty acid metabolism &radic0.088430.65897&radic&radic&radic&radic&radic&radic S000006323CLB2YPR119WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the transition from G2 to Mphase; accumulates during G2 and M, thentargeted via a destruction box motif forubiquitin-mediated degradation by theproteasome 0.088090.65688&radic&radic&radic&radic S000001308MET30YIL046WverifiedF-box protein containing five copies of the WD40 motif,controls cell cycle function, sulfurmetabolism, and methionine biosynthesis as partof the ubiquitin ligase complex; interacts withand regulates Met4p, localizes within thenucleus 0.08840.65688&radic&radic&radic&radic&radic S000003481MGA1YGR249WverifiedProtein similar to heat shock transcription factor; multicopysuppressor of pseudohyphal growth defects ofammonium permease mutants &radic0.087630.65644&radic&radic&radic S000001709VPS1YKR001CverifiedGTPase required for vacuolar protein sorting, functions inactin cytoskeleton organization via itsinteraction with Sla1p; required for lateGolgi-retention of some proteins includingKex2p; involved in regulating peroxisomebiogenesis 0.087070.65461&radic&radic&radic&radic&radic S000002359MGT1YDL200CverifiedDNA repair methyltransferase (6-O-methylguanine-DNA methylase)involved in protection against DNA alkylationdamage 0.087180.65461&radic S000001083SRB2YHR041CverifiedGeneral transcription factor, subunit of the RNA polymerase IImediator complex; associates with corepolymerase subunits to form the RNA polymeraseII holoenzyme; involved in telomere maintenance 0.085910.65229&radic&radic&radic&radic&radic S000001001YAP3YHL009CverifiedBasic leucine zipper (bZIP) transcription factor &radic0.086240.65229&radic&radic&radic&radic&radic&radic&radic S000005169CNM67YNL225CverifiedComponent of the spindle pole body outer plaque; required forspindle orientation and mitotic nuclearmigration 0.085790.65229&radic&radic&radic S000000420YBP1YBR216CverifiedProtein required for oxidation of specific cysteine residues ofthe transcription factor Yap1p, resulting inthe nuclear localization of Yap1p in responseto stress 0.085290.65093&radic&radic&radic&radic&radic&radic S000002770TFC6YDR362CverifiedOne of six subunits of RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part ofTFIIIC TauB domain that binds BoxB promotersites of tRNA and other genes; cooperates withTfc3p in DNA binding; human homolog isTFIIIC-110 0.084240.65063&radic&radic&radic&radic&radic S000004363ROM2YLR371WverifiedGDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutationsare synthetically lethal with mutations inrom1, which also encodes a GEP 0.083310.64859&radic&radic&radic&radic&radic S000005388YAP7YOL028CverifiedPutative basic leucine zipper (bZIP) transcription factor 0.083380.64859&radic&radic&radic&radic&radic S000006156RVB2YPL235WverifiedEssential protein involved in transcription regulation;component of chromatin remodeling complexes;required for assembly and function of the INO80complex; member of the RUVB-like protein family 0.08270.64603&radic S000000961BUR6YER159CverifiedProtein that forms a heterodimeric histone-fold NC2 generaltranscription regulator complex with Ydr1p thatbinds to TBP and represses RNA pol IItranscription during assembly of thepreinitiation complex, homologous to humanNC2alpha 0.08070.6437&radic&radic&radic S000002789YRA1YDR381WverifiedNuclear protein that binds to RNA and to Mex67p, required forexport of poly(A)+ mRNA from the nucleus;member of the REF (RNA and export factorbinding proteins) family; another familymember, Yra2p, can substitute for Yra1pfunction 0.079980.64262&radic&radic&radic&radic&radic&radic S000004793YMR181CUncharacterizedProtein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene 0.079680.64161&radic S000003175SPT16YGL207WverifiedSubunit of the heterodimeric FACT complex (Spt16p-Pob3p),facilitates RNA Polymerase II transcriptionelongation through nucleosomes by destabilizingand then reassembling nucleosome structure 0.079860.64161&radic&radic&radic&radic&radic&radic S000000521DCC1YCL016CverifiedSubunit of a complex with Ctf8p and Ctf18p that shares somecomponents with Replication Factor C, requiredfor sister chromatid cohesion and telomerelength maintenance 0.079780.64161&radic&radic&radic&radic&radic&radic&radic S000004173TOS4YLR183CverifiedTranscription factor that binds to a number of promoterregions, particularly promoters of some genesinvolved in pheromone response and cell cycle;potential Cdc28p substrate; expression isinduced in G1 by bound SBF &radic0.079670.64071&radic&radic&radic&radic&radic S000004525OGG1YML060WverifiedMitochondrial glycosylase/lyase that specifically excises7,8-dihydro-8-oxoguanine residues locatedopposite cytosine or thymine residues in DNA,repairs oxidative damage to mitochondrial DNA 0.079350.64071&radic&radic S000000399MSI1YBR195CverifiedSubunit of chromatin assembly factor I (CAF-I), regulates theRAS/cAMP pathway via sequestration of Npr1pkinase; localizes to the nucleus and cytoplasm;homologous to human retinoblastoma bindingproteins RbAp48 and RbAp46 0.079170.64042&radic&radic&radic&radic&radic&radic S000003865SOD1YJR104CverifiedCytosolic superoxide dismutase; some mutations are analogous tothose that cause ALS (amyotrophic lateralsclerosis) in humans 0.078850.63985&radic&radic&radic S000003055MMS2YGL087CverifiedProtein involved in error-free postreplication DNA repair;forms a heteromeric complex with Ubc13p thathas a ubiquitin-conjugating activity;cooperates with chromatin-associated RINGfinger proteins, Rad18p and Rad5p 0.077770.63639&radic&radic&radic&radic S000004379REH1YLR387CverifiedProtein of unknown function, similar to Rei1p but not involvedin bud growth; contains dispersed C2H2 zincfinger domains 0.077140.63507&radic&radic&radic&radic S000003925RTT109YLL002WverifiedProtein with a role in regulation of Ty1 transposition 0.076480.63333&radic&radic&radic&radic&radic S000001305CBR1YIL043CverifiedMicrosomal cytochrome b reductase, not essential for viability;also detected in mitochondria; mutation inconserved NADH binding domain of the humanortholog results in type I methemoglobinemia 0.076320.63333&radic&radic&radic S000001335SPO22YIL073CverifiedMeiosis-specific protein essential for chromosome synapsis,similar to phospholipase A2, involved incompletion of nuclear divisions during meiosis;induced early in meiosis 0.076150.63333&radic&radic S000003899IML1YJR138WverifiedProtein of unknown function, green fluorescent protein(GFP)-fusion protein localizes to the vacuolarmembrane 0.076190.63333 S000002490RRP8YDR083WverifiedNucleolar protein involved in rRNA processing, pre-rRNAcleavage at site A2; also involved in telomeremaintenance; mutation is synthetically lethalwith a gar1 mutation 0.075960.63305&radic&radic&radic&radic&radic&radic&radic S000002764SPC110YDR356WverifiedInner plaque spindle pole body (SPB) component, ortholog ofhuman kendrin; involved in connecting nuclearmicrotubules to SPB; interacts withTub4p-complex and calmodulin; phosphorylated byMps1p in cell cycle-dependent manner 0.075950.63305&radic&radic&radic&radic&radic S000004626MRPL3YMR024WverifiedMitochondrial ribosomal protein of the large subunit 0.074970.63006 S000002969ERG26YGL001CverifiedC-3 sterol dehydrogenase, catalyzes the second of three stepsrequired to remove two C-4 methyl groups froman intermediate in ergosterol biosynthesis 0.07420.62784&radic&radic&radic&radic S000002524TMA64YDR117CverifiedProtein of unknown function that associates with ribosomes; hasa putative RNA binding domain 0.074780.62784&radic&radic&radic&radic S000004745PSO2YMR137CverifiedRequired for a post-incision step in the repair of DNA singleand double-strand breaks that result frominterstrand crosslinks produced by a variety ofmono- and bi-functional psoralen derivatives;induced by UV-irradiation &radic0.074050.62768&radic&radic&radic S000000772GLY1YEL046CverifiedThreonine aldolase, catalyzes the cleavage of L-allo-threonineand L-threonine to glycine; involved in glycinebiosynthesis 0.073720.62661&radic&radic&radic&radic&radic S000003234SWC4YGR002CverifiedProtein of unknown function, component of the Swr1p complexthat incorporates Htz1p into chromatin;component of the NuA4 histone acetyltransferasecomplex &radic0.073370.62661&radic&radic&radic&radic&radic S000003959PRP19YLL036CverifiedSplicing factor associated with the spliceosome; contains aU-box, a motif found in a class of ubiquitinligases 0.073640.62661&radic&radic&radic&radic S000003992NOC3YLR002CverifiedProtein that forms a nuclear complex with Noc2p that binds to66S ribosomal precursors to mediate theirintranuclear transport; also binds to chromatinto promote the association of DNA replicationfactors and replication initiation 0.072930.62441&radic&radic&radic&radic S000004849TAF9YMR236WverifiedSubunit (17 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification, similar to histone H3 0.071540.62263&radic&radic&radic S000002922YDR514CUncharacterizedHypothetical protein 0.06990.6169&radic S000004045SPT8YLR055CverifiedSubunit of the SAGA transcriptional regulatory complex but notpresent in SAGA-like complex SLIK/SALSA,required for SAGA-mediated inhibition at somepromoters 0.069270.61546&radic&radic&radic&radic&radic&radic&radic S000002599HST4YDR191WverifiedMember of the Sir2 family of NAD(+)-dependent proteindeacetylases; involved along with Hst3p insilencing at telomeres, cell cycle progression,radiation resistance, genomic stability andshort-chain fatty acid metabolism &radic0.069390.61546&radic&radic&radic&radic&radic&radic S000002456YDR049WUncharacterizedZinc finger protein; putative transcription factor that may interact with proteins involved in histone acetylation or deacetylation; may be involved in altering acetylation on histone lysines 0.068980.61488&radic&radic&radic&radic&radic S000001578YJU2YKL095WverifiedEssential nuclear protein; putative spliceosomal componentinvolved in mRNA splicing, based oncomputational analysis of large-scaleprotein-protein interaction data 0.068880.61488&radic S000002872SPP41YDR464WverifiedProtein involved in negative regulation of expression ofspliceosome components PRP4 and PRP3 0.06850.61219&radic&radic&radic&radic S000004812CLN1YMR199WverifiedG1 cyclin involved in regulation of the cell cycle; activatesCdc28p kinase to promote the G1 to S phasetransition; late G1 specific expression dependson transcription factor complexes, MBF(Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) 0.068180.61219&radic&radic&radic&radic&radic&radic S000000248TCM62YBR044CverifiedProtein involved in the assembly of the mitochondrial succinatedehydrogenase complex; putative chaperone 0.068350.61219 S000001847RGD2YFL047WverifiedGTPase-activating protein (RhoGAP) for Cdc42p and Rho5p 0.067920.61219&radic&radic&radic&radic&radic S000004846YMR233WUncharacterizedProtein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; YMR233W is not an essential gene 0.067970.61219&radic&radic&radic&radic&radic&radic S000006403ARR1YPR199CverifiedTranscriptional activator of the bZIP family, required fortranscription of genes involved in resistanceto arsenic compounds 0.067910.61219&radic S000000847ACA1YER045CverifiedBasic leucine zipper (bZIP) transcription factor of theATF/CREB family, may regulate transcription ofgenes involved in utilization of non-optimalcarbon sources 0.067230.61039&radic&radic&radic S000000106YBL010CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles 0.066940.6097&radic&radic S000003626DPB11YJL090CverifiedEssential BRCT repeat protein, required on the prereplicativecomplex at replication origins for loading DNApolymerases to initiate DNA synthesis, alsorequired for S/M checkpoint control 0.066330.60563&radic&radic S000005150RTT106YNL206CverifiedProtein with a role in regulation of Ty1 transposition 0.065940.60563&radic&radic&radic&radic&radic S000002918SMT3YDR510WverifiedUbiquitin-like protein of the SUMO family, conjugated to lysineresidues of target proteins; regulateschromatid cohesion, chromosome segregation,APC-mediated proteolysis, DNA replication andseptin ring dynamics 0.064930.60277&radic&radic&radic S000001608RRN3YKL125WverifiedProtein required for transcription of rDNA by RNA polymerase I;transcription factor independent of DNAtemplate; involved in recruitment of RNApolymerase I to rDNA 0.064670.60148&radic&radic&radic&radic S000001628RPT1YKL145WverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; required for optimalCDC20 transcription; interacts with Rpn12p andthe E3 ubiquitin-protein ligase Ubr1p 0.063890.59872&radic&radic&radic&radic S000005643RPT5YOR117WverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; recruited to theGAL1-10 promoter region upon induction oftranscription 0.063720.59872&radic&radic&radic&radic S000002580ARG82YDR173CverifiedInositol polyphosphate multikinase (IPMK), sequentiallyphosphorylates Ins(1,4,5)P3 to formIns(1,3,4,5,6)P5; putative nuclear lipidinositol PI3-kinase; regulates arginine-,phosphate-, and nitrogen-responsive genes 0.063290.59705&radic&radic&radic&radic&radic&radic&radic&radic&radic S000001602VPH2YKL119CverifiedIntegral membrane protein required for vacuolar H+-ATPase(V-ATPase) function, although not an actualcomponent of the V-ATPase complex; functions inthe assembly of the V-ATPase; localized to theendoplasmic reticulum (ER) 0.06320.59691&radic&radic&radic&radic S000003506TAF1YGR274CverifiedTFIID subunit (145 kDa), involved in RNA polymerase IItranscription initiation, has histoneacetyltransferase activity, involved inpromoter binding and G1/S progression 0.063180.59657&radic&radic&radic S000001243RPN10YHR200WverifiedNon-ATPase base subunit of the 19S regulatory particle (RP) ofthe 26S proteasome; N-terminus plays a role inmaintaining the structural integrity of the RP;binds selectively to polyubiquitin chains;homolog of the mammalian S5a protein 0.063030.59532&radic&radic&radic&radic&radic S000000471REI1YBR267WverifiedCytoplasmic pre-60S factor; required for the correct recyclingof shuttling factors Alb1, Arx1 and Tif6 at theend of the ribosomal large subunit biogenesis;involved in bud growth in the mitotic signalingnetwork 0.062320.59215&radic&radic&radic&radic S000001537DEF1YKL054CverifiedRNAPII degradation factor, forms a complex with Rad26p inchromatin, enables ubiquitination andproteolysis of RNAPII present in an elongationcomplex 0.061640.59215&radic&radic&radic&radic&radic S000004125SLX4YLR135WverifiedSubunit of a complex, with Slx1p, that hydrolyzes 5' branchesfrom duplex DNA in response to stalled orconverging replication forks; function overlapswith that of Sgs1p-Top3p 0.061490.59166&radic&radic&radic&radic S000002817SIZ1YDR409WverifiedSUMO ligase that promotes the attachment of sumo (Smt3p; smallubiquitin-related modifier) to proteins; bindsUbc9p and may bind septins; specificallyrequired for sumoylation of septins in vivo;localized to the septin ring 0.061330.5906&radic&radic&radic&radic S000004889DSK2YMR276WverifiedNuclear-enriched ubiquitin-like polyubiquitin-binding protein,required for spindle pole body (SPB)duplication and for transit through the G2/Mphase of the cell cycle, involved inproteolysis, interacts with the proteasome 0.061280.5906&radic&radic&radic&radic&radic&radic&radic&radic S000002736SKP1YDR328CverifiedEvolutionarily conserved kinetochore protein that is part ofmultiple protein complexes, including the SCFubiquitin ligase complex, the CBF3 complex thatbinds centromeric DNA, and the RAVE complexthat regulates assembly of the V-ATPase &radic0.061330.5906&radic&radic&radic&radic S000002805NCB2YDR397CverifiedBeta subunit of the NC2 dimeric histone-fold complex; repressesRNA polymerase II transcription through bindingto TBP and inhibition of TFIIA and TFIIB;homologous to the Dr1 subunit of the mammalianNC2 (negative cofactor2) 0.061130.5906&radic&radic&radic&radic&radic S000000121RRN10YBL025WverifiedProtein involved in promoting high level transcription of rDNA,subunit of UAF (upstream activation factor) forRNA polymerase I &radic0.061120.59027&radic&radic&radic&radic S000000964RAD4YER162CverifiedProtein that recognizes and binds damaged DNA (with Rad23p)during nucleotide excision repair; subunit ofNuclear Excision Repair Factor 2 (NEF2);homolog of human XPC protein &radic0.061040.59027&radic&radic S000005932TAF3YPL011CverifiedTFIID subunit (47 kDa), involved in promoter binding and RNApolymerase II transcription initiation 0.060760.58908&radic&radic&radic&radic S000003684RPA34YJL148WverifiedRNA polymerase I subunit A34.5 0.059860.58567&radic&radic&radic&radic&radic&radic S000000277RDH54YBR073WverifiedDNA-dependent ATPase, stimulates strand exchange by modifyingthe topology of double-stranded DNA; involvedin the recombinational repair of double-strandbreaks in DNA during mitosis and meiosis;proposed to be involved in crossoverinterference &radic0.059390.58473&radic S000000285SPT7YBR081CverifiedSubunit of the SAGA transcriptional regulatory complex,involved in proper assembly of the complex;also present as a C-terminally truncated formin the SLIK/SALSA transcriptional regulatorycomplex 0.059290.58451&radic&radic&radic S000001318VHR1YIL056WuncharacterizedTranscriptional activator, required for the vitaminH-responsive element (VHRE) mediated inductionof VHT1 (Vitamin H transporter) and BIO5(biotin biosynthesis intermediate transporter)in response to low biotin concentrations &radic0.059180.58451&radic&radic S000002433YDR026CUncharacterizedPutative transcription factor; Myb-like DNA-binding protein that may bind to the Ter region of rDNA; interacts physically with Fob1p, although this interaction is not involved in replication fork arrest &radic0.058860.58404 S000002284CDC48YDL126CverifiedATPase in ER, nuclear membrane and cytosol with homology tomammalian p97; in a complex with Npl4p andUfd1p participates in retrotranslocation ofubiquitinated proteins from the ER into thecytosol for degradation by the proteasome 0.058830.58333&radic&radic&radic&radic S000003372CBF2YGR140WverifiedEssential kinetochore protein, component of the CBF3multisubunit complex that binds to the CDEIIIregion of the centromere; Cbf2p also binds tothe CDEII region possibly forming a differentmultimeric complex, ubiquitinated in vivo &radic0.058370.58193&radic&radic&radic&radic&radic&radic S000001315RHR2YIL053WverifiedConstitutively expressed isoform of DL-glycerol-3-phosphatase;involved in glycerol biosynthesis, induced inresponse to both anaerobic and, along with theHor2p/Gpp2p isoform, osmotic stress 0.058220.58114&radic&radic&radic&radic&radic&radic S000004925PSE1YMR308CverifiedKaryopherin/importin that interacts with the nuclear porecomplex; acts as the nuclear import receptorfor specific proteins, including Pdr1p, Yap1p,Ste12p, and Aft1p 0.058270.58114&radic&radic S000000025YAL027WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YAL027W is a non-essential gene 0.058080.58074&radic&radic&radic S000001927SMC2YFR031CverifiedComponent of the condensin complex, essential SMC chromosomalATPase family member that forms a complex withSmc4p to form the active ATPase; Smc2p/Smc4pcomplex binds DNA, possibly in the cleft formedby the coiled-coil of the folded dimer &radic0.058070.58074&radic&radic S000001195SPO12YHR152WverifiedNucleolar protein of unknown function, positive regulator ofexit from mitosis; involved in regulating therelease of Cdc14p from the nucleolus in earlyanaphase; proposed to play similar role inmeiosis 0.057520.57556&radic S000002161MCD1YDL003WverifiedEssential protein required for sister chromatid cohesion inmitosis and meiosis; subunit of the cohesincomplex; expression is cell cycle regulated andpeaks in S phase 0.057850.57556&radic&radic&radic S000005173URE2YNL229CverifiedNitrogen catabolite repression regulator that acts byinhibition of GLN3 transcription in goodnitrogen source; altered form of Ure2p creates[URE3] prion 0.057240.57556&radic&radic&radic&radic S000000427TDP1YBR223CverifiedTyrosyl-DNA Phosphodiesterase I, hydrolyzes 3'-phosphotyrosylbonds to generate 3'-phosphate DNA andtyrosine, involved in the repair of DNA lesionscreated by topoisomerase I 0.057670.57556&radic&radic&radic&radic&radic S000001906UBP6YFR010WverifiedUbiquitin-specific protease situated in the base subcomplex ofthe 26S proteasome, releases free ubiquitinfrom branched polyubiquitin chains; deletioncauses hypersensitivity to cycloheximide andother toxic compounds 0.057240.57556&radic&radic&radic&radic&radic&radic&radic&radic&radic S000006175HFI1YPL254WverifiedAdaptor protein required for structural integrity of the SAGAcomplex, a histoneacetyltransferase-coactivator complex that isinvolved in global regulation of geneexpression through acetylation andtranscription functions 0.057250.57556&radic&radic&radic&radic&radic&radic&radic S000003130SUT1YGL162WverifiedTranscription factor of the Zn[II]2Cys6 family involved insterol uptake; involved in induction of hypoxicgene expression &radic0.056280.57319&radic&radic S000001381RPI1YIL119CverifiedPutative transcriptional regulator; overexpression suppressesthe heat shock sensitivity of wild-type RAS2overexpression and also suppresses the celllysis defect of an mpk1 mutation 0.056790.57319&radic&radic&radic S000001494CCE1YKL011CverifiedMitochondrial cruciform cutting endonuclease, cleaves Hollidayjunctions formed during recombination ofmitochondrial DNA 0.056020.57177&radic S000000516SGF29YCL010CverifiedSaGa associated Factor 29kDa; Probable 29kKDa Subunit of SAGAhistone acetyltransferase complex 0.056250.57177&radic&radic S000003213RTF1YGL244WverifiedSubunit of the RNA polymerase II-associated Paf1 complex;directly or indirectly regulates DNA-bindingproperties of Spt15p and relative activities ofdifferent TATA elements; involved in telomeremaintenance 0.055650.56997&radic&radic&radic&radic&radic&radic&radic S000002528DPB4YDR121WverifiedShared subunit of DNA polymerase epsilon and of ISW2/yCHRACchromatin accessibility complex; involved inboth chromosomal DNA replication and ininheritance of telomeric silencing 0.054990.56692&radic&radic&radic&radic&radic&radic S000002743MSN5YDR335WverifiedKaryopherin involved in nuclear import and export; shown to beresponsible for nuclear import of replicationprotein A and for export of several proteinsincluding Swi6p, Far1p, and Pho4p; cargodissociation involves binding to RanGTP 0.055390.56692&radic&radic&radic&radic S000002299RPO21YDL140CverifiedRNA polymerase II largest subunit B220, part of central core;phosphorylation of C-terminal heptapeptiderepeat domain regulates association withtranscription and splicing factors; similar tobacterial beta-prime 0.055160.56692&radic&radic S000000189ROX3YBL093CverifiedRNA polymerase II holoenzyme component 0.055290.56692&radic&radic&radic&radic S000001288IRR1YIL026CverifiedSubunit of the cohesin complex, which is required for sisterchromatid cohesion during mitosis and meiosisand interacts with centromeres and chromosomearms, essential for viability 0.055080.56692&radic&radic&radic&radic&radic S000002583NGG1YDR176WverifiedTranscriptional regulator involved in glucose repression ofGal4p-regulated genes; component oftranscriptional adaptor and histoneacetyltransferase complexes, the ADA complex,the SAGA complex, and the SLIK complex 0.054910.56692&radic&radic&radic S000000566MRC1YCL061CverifiedS-phase checkpoint protein found at replication forks, requiredfor DNA replication; also required for Rad53pactivation during DNA replication stress, whereit forms a replication-pausing complex withTof1p and is phosphorylated by Mec1p; proteininvolved in replication checkpoint 0.055090.56692&radic&radic&radic&radic&radic S000000912KAP123YER110CverifiedKaryopherin beta, mediates nuclear import of ribosomal proteinsprior to assembly into ribosomes and import ofhistones H3 and H4; localizes to the nuclearpore, nucleus, and cytoplasm; exhibits geneticinteractions with RAI1 0.05490.56692&radic&radic&radic&radic S000002461CDC34YDR054CverifiedUbiquitin-conjugating enzyme or E2; together with Skp1p, Rbx1p,Cdc53p, and an F-box protein, forms aubiquitin-protein ligase called the SCF complexwhich regulates cell cycle progression bytargeting key substrates for degradation 0.054050.56388&radic&radic&radic&radic S000002175CDC7YDL017WverifiedDDK (Dbf4-dependent kinase) catalytic subunit required forfiring origins and replication fork progressionin mitosis through phosphorylation of Mcm2-7pcomplexes and Cdc45p; kinase activitycorrelates with cyclical DBF4 expression 0.054670.56388&radic&radic&radic&radic&radic S000003237TFG2YGR005CverifiedTFIIF (Transcription Factor II) middle subunit; involved inboth transcription initiation and elongation ofRNA polymerase II; homologous to human RAP30 0.054130.56388&radic&radic S000003016RPT6YGL048CverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; bound byubiquitin-protein ligases Ubr1p and Ufd4p;localized mainly to the nucleus throughout thecell cycle 0.054460.56388&radic&radic&radic&radic&radic S000003303YGR071CUncharacterizedPutative protein of unknown function; deletion mutant has increased glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the nucleus 0.053920.56129&radic&radic&radic&radic&radic S000004651CSM3YMR048WverifiedProtein required for accurate chromosome segregation duringmeiosis 0.053260.56129&radic&radic S000004840TAF7YMR227CverifiedTFIID subunit (67 kDa), involved in RNA polymerase IItranscription initiation 0.05370.56129&radic&radic&radic&radic&radic&radic S000003210KAP114YGL241WverifiedKaryopherin, responsible for nuclear import of Spt15p, histonesH2A and H2B, and Nap1p; amino terminus showssimilarity to those of other importins,particularly Cse1p; localization is primarilynuclear 0.053620.56129&radic&radic&radic&radic S000005361PHO80YOL001WverifiedCyclin, negatively regulates phosphate metabolism;Pho80p-Pho85p (cyclin-CDK complex)phosphorylates Pho4p and Swi5p; deletion ofPHO80 leads to aminoglycoside supersensitivity;truncated form of PHO80 affects vacuoleinheritance 0.053920.56129&radic&radic&radic&radic S000000402TAF5YBR198CverifiedSubunit (90 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification 0.053710.56129&radic&radic&radic&radic&radic S000003080TAF6YGL112CverifiedSubunit (60 kDa) of TFIID and SAGA complexes, involved intranscription initiation of RNA polymerase IIand in chromatin modification, similar tohistone H4 0.053050.56038&radic S000002290CDC53YDL132WverifiedCullin, structural protein of SCF complexes (which also containSkp1p, Cdc34p, and an F-box protein) involvedin ubiquitination; SCF promotes the G1-Stransition by targeting G1 cyclins and theCln-CDK inhibitor Sic1p for degradation &radic0.052080.55792&radic&radic&radic&radic S000000004SSA1YAL005CverifiedATPase involved in protein folding and nuclear localizationsignal (NLS)-directed nuclear transport; memberof heat shock protein 70 (HSP70) family; formsa chaperone complex with Ydj1p; localized tothe nucleus, cytoplasm, and cell wall 0.052110.55792&radic&radic&radic&radic&radic&radic&radic S000005366TOP1YOL006CverifiedTopoisomerase I, nuclear enzyme that relieves torsional strainin DNA by cleaving and re-sealing thephosphodiester backbone; relaxes bothpositively and negatively supercoiled DNA;functions in replication, transcription, andrecombination &radic0.051940.55755&radic&radic&radic&radic&radic S000005553STI1YOR027WverifiedHsp90 cochaperone, interacts with the Ssa group of thecytosolic Hsp70 chaperones; activates theATPase activity of Ssa1p; homolog of mammalianHop protein 0.051450.55451&radic&radic&radic&radic S000001447PRI1YIR008CverifiedSubunit of DNA primase, which is required for DNA synthesis anddouble-strand break repair 0.051490.55451 S000001597APN1YKL114CverifiedMajor apurinic/apyrimidinic endonuclease, 3'-repair diesteraseinvolved in repair of DNA damage by oxidationand alkylating agents; also functions as a3'-5' exonuclease to repair7,8-dihydro-8-oxodeoxyguanosine 0.051780.55451&radic&radic&radic&radic&radic S000002674YDR266CUncharacterizedHypothetical protein 0.051360.55451&radic&radic&radic&radic&radic&radic S000005549AHC1YOR023CverifiedSubunit of the Ada histone acetyltransferase complex, requiredfor structural integrity of the complex 0.051810.55451&radic&radic&radic&radic&radic S000000115APN2YBL019WverifiedClass II abasic (AP) endonuclease involved in repair of DNAdamage; homolog of human HAP1 and E. coliexoIII 0.051750.55451&radic&radic&radic&radic&radic&radic&radic S000005939CTF19YPL018WverifiedOuter kinetochore protein, required for accurate mitoticchromosome segregation; component of thekinetochore sub-complex COMA (Ctf19p, Okp1p,Mcm21p, Ame1p) that functions as a platform forkinetochore assembly 0.051380.55451&radic&radic&radic&radic S000003850GRR1YJR090CverifiedF-box protein component of the SCF ubiquitin-ligase complex,required for Cln1p and Cln2p degradation;involved in carbon catabolite repression,glucose-dependent divalent cation transport,high-affinity glucose transport, andmorphogenesis 0.050970.5509 S000005602SKI7YOR076CverifiedAntiviral adaptor protein that mediates interactions via itsN-terminus between the exosome and Ski complex(Ski2p, Ski3p, Ski8p) which operate in the3'-to-5' mRNA-decay pathway; cytoplasmicprotein required for degrading nonstop mRNAs 0.05070.5509&radic S000000303YBR099CDubiousHypothetical protein 0.050640.5509&radic S000005670ELG1YOR144CverifiedProtein required for S phase progression and telomerehomeostasis, forms an alternative replicationfactor C complex important for DNA replicationand genome integrity; involved in homologousrecombination-mediated DNA repair 0.050890.5509&radic&radic&radic S000000288MIS1YBR084WverifiedMitochondrial C1-tetrahydrofolate synthase, involved ininterconversion between different oxidationstates of tetrahydrofolate (THF); providesactivities of formyl-THF synthetase,methenyl-THF cyclohydrolase, and methylene-THFdehydrogenase 0.050820.5509 S000003804POL32YJR043CverifiedThird subunit of DNA polymerase delta, involved in chromosomalDNA replication; required for error-prone DNAsynthesis in the presence of DNA damage andprocessivity; interacts with Hys2p, PCNA(Pol30p), and Pol1p 0.050790.5509&radic&radic&radic S000006373JIP5YPR169WuncharacterizedNucleolar protein of unknown function, exhibits a physicalinteraction with Bre1p 0.05030.54918&radic&radic&radic&radic&radic S000004165CBF5YLR175WverifiedPseudouridine synthase catalytic subunit of box H/ACA smallnucleolar ribonucleoprotein particles(snoRNPs), acts on both large and small rRNAsand on snRNA U2 0.050530.54918&radic&radic&radic&radic&radic&radic S000002812RPB7YDR404CverifiedRNA polymerase II subunit B16; forms two subunit dissociablecomplex with Rpb4p 0.050270.54918&radic&radic&radic S000004523SML1YML058WverifiedRibonucleotide reductase inhibitor involved in regulating dNTPproduction; regulated by Mec1p and Rad53pduring DNA damage and S phase 0.050110.54891&radic&radic&radic S000003963VPS13YLL040CverifiedProtein of unknown function; heterooligomeric or homooligomericcomplex; peripherally associated withmembranes; homologous to human COH1; involvedin sporulation, vacuolar protein sorting andprotein-Golgi retention 0.050090.54891&radic&radic S000000770IES6YEL044WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.050020.54822&radic&radic S000004582TAF8YML114CverifiedTFIID subunit (65 kDa), involved in RNA polymerase IItranscription initiation 0.049450.54517&radic&radic S000002993PGD1YGL025CverifiedSubunit of the Mediator global transcriptional cofactorcomplex, which is part of the RNA polymerase IIholoenzyme and plays an essential role in basaland activated transcription; direct target ofthe Cyc8p-Tup1p transcriptional corepressor 0.049810.54517&radic&radic&radic&radic&radic S000005192RPA49YNL248CverifiedRNA polymerase I subunit A49 0.049630.54517&radic&radic&radic&radic S000006345KAR3YPR141CverifiedMinus-end-directed microtubule motor that functions in mitosisand meiosis, localizes to the spindle pole bodyand localization is dependent on functionalCik1p, required for nuclear fusion duringmating; potential Cdc28p substrate 0.049840.54517&radic&radic&radic S000002482PPH3YDR075WverifiedCatalytic subunit of an evolutionarily conserved proteinphosphatase complex containing Psy2p and theregulatory subunit Psy4p; required forcisplatin resistance; involved in activation ofGln3p 0.049570.54517&radic&radic&radic&radic&radic&radic&radic S000004012SDO1YLR022CuncharacterizedEssential protein involved in RNA metabolism, one of two yeasthomologs (with Yhr087wp) of the human proteinSBDS responsible for autosomal recessiveShwachman-Bodian-Diamond Syndrome, alsoconserved in Archaea 0.049490.54517&radic&radic&radic&radic&radic S000004117APC2YLR127CverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition; similar tocullin Cdc53p 0.049920.54517&radic&radic&radic&radic&radic&radic&radic&radic S000001924CDC14YFR028CverifiedProtein phosphatase required for mitotic exit; located in thenucleolus until liberated by the FEAR andMitotic Exit Network in anaphase, enabling itto act on key substrates to effect a decreasein CDK/B-cyclin activity and mitotic exit 0.049480.54517&radic&radic&radic S000002732UTP4YDR324CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.049610.54517&radic&radic&radic&radic S000001923ECO1YFR027WverifiedAcetyltransferase required for the establishment of sisterchromatid cohesion during DNA replication, butnot for its maintenance during G2 and M phases;also required for postreplicative double-strandbreak repair; interacts with Chl1p 0.049320.54414&radic&radic&radic&radic&radic&radic S000002598RVB1YDR190CverifiedEssential protein involved in transcription regulation;component of chromatin remodeling complexes;required for assembly and function of the INO80complex; member of the RUVB-like protein family 0.049240.54414&radic&radic&radic&radic S000001789RPF2YKR081CverifiedEssential protein involved in the processing of pre-rRNA andthe assembly of the 60S ribosomal subunit;interacts with ribosomal protein L11; localizespredominantly to the nucleolus; constituent of66S pre-ribosomal particles 0.048960.54321&radic&radic&radic&radic S000000301VPS15YBR097WverifiedMyristoylated serine/threonine protein kinase involved invacuolar protein sorting; functions as amembrane-associated complex with Vps34p; activeform recruits Vps34p to the Golgi membrane;interacts with the GDP-bound form of Gpa1p 0.048960.54321&radic&radic S000001622CTK1YKL139WverifiedCatalytic (alpha) subunit of C-terminal domain kinase I(CTDK-I), which phosphorylates the C-terminalrepeated domain of the RNA polymerase II largesubunit (Rpo21p) to affect both transcriptionand pre-mRNA 3' end processing 0.048970.54321&radic&radic&radic&radic S000002987CKB1YGL019WverifiedBeta regulatory subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKA2 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.048830.53866&radic&radic&radic&radic&radic S000002520PDS1YDR113CverifiedSecurin that inhibits anaphase by binding separin Esp1p, alsoblocks cyclin destruction and mitotic exit,essential for cell cycle arrest in mitosis inthe presence of DNA damage or aberrant mitoticspindles; also present in meiotic nuclei 0.048680.53866&radic&radic&radic S000006314RPC40YPR110CverifiedRNA polymerase subunit, common to RNA polymerase I and III 0.048480.53866&radic&radic&radic&radic S000006290SUA7YPR086WverifiedTranscription factor TFIIB, a general transcription factorrequired for transcription initiation and startsite selection by RNA polymerase II 0.048730.53866&radic&radic&radic S000000419HPC2YBR215WverifiedHighly charged, basic protein required for normal cell-cycleregulation of histone gene transcription;mutants display strong synthetic defects withsubunits of FACT, a complex that allows RNA PolII to elongate through nucleosomes 0.047930.53866&radic&radic&radic&radic&radic S000002786LSM6YDR378CverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.048690.53866&radic&radic&radic&radic&radic&radic&radic S000001405SSL2YIL143CverifiedComponent of the holoenzyme form of RNA polymerasetranscription factor TFIIH, has DNA-dependentATPase/helicase activity and is required, withRad3p, for unwinding promoter DNA; involved inDNA repair; homolog of human ERCC3 0.048530.53866&radic&radic&radic S000000316CYC8YBR112CverifiedGeneral transcriptional co-repressor, acts together with Tup1p;also acts as part of a transcriptionalco-activator complex that recruits the SWI/SNFand SAGA complexes to promoters 0.048520.53866&radic&radic S000002242SUB2YDL084WverifiedComponent of the TREX complex required for nuclear mRNA export;member of the DEAD-box RNA helicase superfamilyand is involved in early and late steps ofspliceosome assembly; homolog of the humansplicing factor hUAP56 0.048250.53866&radic&radic S000004924GAS1YMR307WverifiedBeta-1.3-glucanosyltransferase, required for cell wallassembly; localizes to the cell surface via aglycosylphosphatidylinositol (GPI) anchor 0.047910.53866&radic&radic&radic&radic&radic S000004774MSS11YMR164CverifiedTranscription factor involved in regulation of invasive growthand starch degradation; controls the activationof MUC1 and STA2 in response to nutritionalsignals 0.048230.53866&radic&radic&radic&radic S000000292POL30YBR088CverifiedProliferating cell nuclear antigen (PCNA), functions as thesliding clamp for DNA polymerase delta; mayfunction as a docking site for other proteinsrequired for mitotic and meiotic chromosomalDNA replication and for DNA repair 0.048210.53866&radic&radic&radic S000000015PSK1YAL017WverifiedOne of two (see also PSK2) PAS domain containing S/T proteinkinases; coordinately regulates proteinsynthesis and carbohydrate metabolism andstorage in response to a unknown metabolitethat reflects nutritional status 0.047610.53775&radic S000001164YHR122WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; may be involved in transcription; YHR122W is an essential gene 0.047690.53775&radic&radic&radic&radic S000004041FCF2YLR051CverifiedEssential nucleolar protein involved in the early steps of 35SrRNA processing; interacts with Faf1p; memberof a transcriptionally co-regulated set ofgenes called the RRB regulon 0.047660.53775&radic&radic&radic S000003465PHO81YGR233CverifiedCyclin-dependent kinase (CDK) inhibitor, regulatesPho80p-Pho85p and Pcl7p-Pho85p cyclin-CDKcomplexes in response to phosphate levels;required for derepression of PHO5;transcriptionally regulated by Pho4p and Pho2p 0.04740.53464&radic&radic S000001497URB1YKL014CverifiedNucleolar protein required for the normal accumulation of 25Sand 5.8S rRNAs, associated with the 27SA2pre-ribosomal particle; proposed to be involvedin the biogenesis of the 60S ribosomal subunit 0.046920.53464 S000000017FUN30YAL019WverifiedProtein whose overexpression affects chromosome stability,potential Cdc28p substrate; homolog of Snf2p;the authentic, non-tagged protein is detectedin highly purified mitochondria inhigh-throughput studies 0.047090.53464&radic&radic&radic S000003207CSE1YGL238WverifiedNuclear envelope protein that mediates the nuclear export ofimportin alpha (Srp1p), homolog of metazoan CASprotein, required for accurate chromosomesegregation 0.046970.53464&radic&radic&radic&radic&radic&radic S000006050TAF14YPL129WverifiedSubunit (30 kDa) of TFIID, TFIIF, and SWI/SNF complexes,involved in RNA polymerase II transcriptioninitiation and in chromatin modification,contains a YEATS domain 0.046890.53464&radic&radic&radic&radic&radic&radic S000002408NTH1YDR001CverifiedNeutral trehalase, degrades trehalose; required forthermotolerance and may mediate resistance toother cellular stresses; may be phosphorylatedby Cdc28p 0.047430.53464&radic&radic S000002744YDR336WUncharacterizedPutative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene 0.047090.53464&radic&radic&radic&radic S000005649LEO1YOR123CverifiedComponent of the Paf1 complex, which associates with RNApolymerase II and is involved in histonemethylation 0.046790.53447&radic&radic S000005559EXO1YOR033Cverified5'-3' exonuclease and flap-endonuclease involved inrecombination, double-strand break repair andDNA mismatch repair; member of the Rad2pnuclease family, with conserved N and Inuclease domains 0.046470.53286&radic&radic&radic&radic&radic S000002802RPT3YDR394WverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; substrate ofN-acetyltransferase B 0.046410.53286&radic&radic&radic&radic&radic S000002796RVS167YDR388WverifiedActin-associated protein, subunit of a complex(Rvs161p-Rvs167p) involved in regulation ofactin cytoskeleton, endocytosis, and viabilityfollowing starvation or osmotic stress; homologof mammalian amphiphysin 0.046380.53286&radic&radic&radic S000004564TAF13YML098WverifiedTFIID subunit (19 kDa), involved in RNA polymerase IItranscription initiation, similar to histone H4with atypical histone fold motif of Spt3-liketranscription factors 0.046590.53286&radic&radic&radic S000002574TAF10YDR167WverifiedSubunit (145 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification 0.046580.53286&radic&radic&radic&radic&radic&radic S000003849BIR1YJR089WverifiedEssential chromosomal passenger protein involved incoordinating cell cycle events for properchromosome segregation; C-terminal region bindsSli15p, and the middle region, uponphosphorylation, localizes Cbf2p to the spindleat anaphase 0.046370.53277&radic&radic&radic S000005176CSL4YNL232WverifiedSubunit of the exosome, which is an essential complex presentin both nucleus and cytoplasm that mediates RNAprocessing and degradation 0.046120.53085&radic&radic&radic&radic&radic&radic&radic S000004131RRN5YLR141WverifiedProtein involved in transcription of rDNA by RNA polymerase I;transcription factor, member of UAF (upstreamactivation factor) family along with Rrn9p andRrn10p &radic0.045940.53085&radic&radic&radic S000002222UBC9YDL064WverifiedSUMO-conjugating enzyme involved in the Smt3p conjugationpathway; nuclear protein required for S- andM-phase cyclin degradation and mitotic control;involved in proteolysis mediated by theanaphase-promoting complex cyclosome (APCC) 0.046060.53085&radic&radic&radic&radic&radic S000002635SIR4YDR227WverifiedSilent information regulator that, together with SIR2 and SIR3,is involved in assembly of silent chromatindomains at telomeres and the silent mating-typeloci; potentially phosphorylated by Cdc28p;some alleles of SIR4 prolong lifespan 0.04630.53085&radic&radic S000001696DOA1YKL213CverifiedWD repeat protein required for ubiquitin-mediated proteindegradation, forms complex with Cdc48p, plays arole in controlling cellular ubiquitinconcentration; also promotes efficient NHEJ inpostdiauxic/stationary phase 0.045620.52942&radic&radic&radic&radic&radic&radic S000003221RTG2YGL252CverifiedSensor of mitochondrial dysfunction; regulates the subcellularlocation of Rtg1p and Rtg3p, transcriptionalactivators of the retrograde (RTG) and TORpathways; Rtg2p is inhibited by thephosphorylated form of Mks1p 0.045730.52942&radic&radic S000004187SIK1YLR197WverifiedEssential evolutionarily-conserved nucleolar protein componentof the box C/D snoRNP complexes that direct2'-O-methylation of pre-rRNA during itsmaturation; over