Yfunc lets you browse current and predicted gene functions in yeast

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Prediction of GO:0004386 "helicase activity"

GO branch: MF
Number of currently annotated genes: 91

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest Huh:nucleusPF00176PF00270IPR011545IPR000330TAP:116IPR001650PS51192PF00271Dudley:HU S000005572DBP5YOR046CverifiedCytoplasmic ATP-dependent RNA helicase of the DEAD-box familyinvolved in mRNA export from the nucleus &radic0.765431&radic&radic&radic&radic&radic S000004903HAS1YMR290CverifiedATP-dependent RNA helicase; localizes to both the nuclearperiphery and nucleolus; highly enriched innuclear pore complex fractions; constituent of66S pre-ribosomal particles &radic0.795851&radic&radic&radic&radic&radic S000001767TIF1YKR059WverifiedTranslation initiation factor eIF4A, identical to Tif2p;DEA(D/H)-box RNA helicase that couples ATPaseactivity to RNA binding and unwinding; forms adumbbell structure of two compact domainsconnected by a linker; interacts with eIF4G &radic0.767991&radic&radic&radic&radic&radic S000003570HCA4YJL033WverifiedPutative nucleolar DEAD box RNA helicase; high-copy numbersuppression of a U14 snoRNA processing mutantsuggests an involvement in 18S rRNA synthesis &radic0.760941&radic&radic&radic&radic&radic S000003674TIF2YJL138CverifiedTranslation initiation factor eIF4A, identical to Tif1p;DEA(D/H)-box RNA helicase that couples ATPaseactivity to RNA binding and unwinding; forms adumbbell structure of two compact domainsconnected by a linker; interacts with eIF4G &radic0.762351&radic&radic&radic&radic&radic S000004802SGS1YMR190CverifiedNucleolar DNA helicase of the RecQ family involved inmaintenance of genome integrity, regulateschromosome synapsis and meiotic crossing over;has similarity to human BLM and WRN helicasesimplicated in Bloom and Werner syndromes &radic0.720480.98165&radic&radic&radic&radic&radic&radic&radic S000004266DBP9YLR276CverifiedATP-dependent RNA helicase of the DEAD-box family involved inbiogenesis of the 60S ribosomal subunit &radic0.756670.98165&radic&radic&radic&radic&radic S000002428FAL1YDR021WverifiedNucleolar protein required for maturation of 18S rRNA, memberof the eIF4A subfamily of DEAD-boxATP-dependent RNA helicases &radic0.72820.98165&radic&radic&radic&radic&radic&radic S000001732DBP7YKR024CverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in ribosomal biogenesis &radic0.719990.98165&radic&radic&radic&radic&radic&radic S000005730DED1YOR204WverifiedATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, requiredfor translation initiation of all yeast mRNAs;mutations in human DEAD-box DBY are a frequentcause of male infertility &radic0.754510.98165&radic&radic&radic&radic&radic S000002319DHH1YDL160CverifiedCytoplasmic DExD/H-box helicase, stimulates mRNA decapping,coordinates distinct steps in mRNA function anddecay, interacts with both the decapping anddeadenylase complexes, may have a role in mRNAexport and translation &radic0.758740.98165&radic&radic&radic&radic&radic&radic S000001894SPB4YFL002CverifiedPutative ATP-dependent RNA helicase, nucleolar protein requiredfor synthesis of 60S ribosomal subunits at alate step in the pathway; sediments with 66Spre-ribosomes in sucrose gradients &radic0.71990.98165&radic&radic&radic&radic&radic&radic S000000346MAK5YBR142WverifiedEssential nucleolar protein, putative DEAD-box RNA helicaserequired for maintenance of M1 dsRNA virus;involved in biogenesis of large (60S) ribosomalsubunits &radic0.755430.98165&radic&radic&radic&radic&radic&radic S000002651PRP28YDR243CverifiedRNA helicase in the DEAD-box family, involved in RNAisomerization at the 5' splice site &radic0.685780.98165&radic&radic&radic&radic&radic&radic S000002602MSS116YDR194CverifiedDEAD-box protein required for efficient splicing ofmitochondrial Group I and II introns; non-polarRNA helicase that also facilities strandannealing &radic0.726360.98165&radic&radic&radic&radic&radic S000005321DBP6YNR038WverifiedEssential protein involved in ribosome biogenesis; putativeATP-dependent RNA helicase of the DEAD-boxprotein family &radic0.745480.98165&radic&radic&radic&radic&radic&radic S000002242SUB2YDL084WverifiedComponent of the TREX complex required for nuclear mRNA export;member of the DEAD-box RNA helicase superfamilyand is involved in early and late steps ofspliceosome assembly; homolog of the humansplicing factor hUAP56 &radic0.719430.98165&radic&radic&radic&radic&radic&radic S000003503SLH1YGR271WverifiedPutative RNA helicase related to Ski2p, involved in translationinhibition of non-poly(A) mRNAs; required forrepressing propagation of dsRNA viruses &radic0.677820.98165&radic&radic&radic&radic&radic S000000974BRR2YER172CverifiedRNA-dependent ATPase RNA helicase involved in the facilitationand disruption of snRNA interactions, requiredfor disruption of U4/U6 base-pairing in nativesnRNPs to activate the spliceosome forcatalysis &radic0.673150.9752&radic&radic&radic&radic&radic&radic S000003586MTR4YJL050WverifiedDead-box family ATP dependent helicase required for mRNA exportfrom the nucleus; co-factor of the exosomecomplex, required for 3' end formation of 5.8SrRNA &radic0.675730.9752&radic&radic&radic&radic&radic&radic S000001794PRP16YKR086WverifiedRNA helicase in the DEAH-box family involved in the secondcatalytic step of splicing, exhibitsATP-dependent RNA unwinding activity &radic0.645530.95823&radic&radic&radic&radic&radic&radic S000000406CDC47YBR202WverifiedComponent of the hexameric MCM complex, which is important forpriming origins of DNA replication in G1 andbecomes an active ATP-dependent helicase thatpromotes DNA melting and elongation whenactivated by Cdc7p-Dbf4p in S-phase &radic0.610740.95823&radic S000006223CDC54YPR019WverifiedEssential helicase component of heterohexameric MCM2-7complexes which bind pre-replication complexeson DNA and melt the DNA prior to replication;accumulates in the nucleus in G1; homolog of S.pombe Cdc21p &radic0.616970.95823&radic S000002740IRC3YDR332WuncharacterizedHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci &radic0.637990.95823&radic&radic&radic&radic&radic S000005056DBP2YNL112WverifiedEssential ATP-dependent RNA helicase of the DEAD-box proteinfamily, involved in nonsense-mediated mRNAdecay and rRNA processing &radic0.642450.95823&radic&radic&radic&radic&radic&radic S000001212DBP8YHR169WverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in biogenesis of the 40S ribosomalsubunit &radic0.60130.95823&radic&radic&radic&radic&radic&radic S000004390SKI2YLR398CverifiedPutative RNA helicase, involved in exosome mediated 3' to 5'mRNA degradation and translation inhibition ofnon-poly(A) mRNAs; forms complex with Ski3p andSki8p; required for repressing propagation ofdsRNA viruses &radic0.669070.95823&radic&radic&radic&radic&radic S000001441MPH1YIR002CverifiedMember of the DEAH family of helicases, functions in anerror-free DNA damage bypass pathway thatinvolves homologous recombination, mutationsconfer a mutator phenotype &radic0.641660.95823&radic&radic&radic&radic&radic&radic S000003139ROK1YGL171WverifiedATP-dependent RNA helicase of the DEAD box family; required for18S rRNA synthesis &radic0.61470.95823&radic&radic&radic&radic&radic S000003169MCM6YGL201CverifiedProtein involved in DNA replication; component of the Mcm2-7hexameric complex that binds chromatin as apart of the pre-replicative complex &radic0.577360.95823&radic S000003032MRH4YGL064CverifiedMitochondrial RNA helicase of the DEAD-box family, plays anessential role in mitochondrial function &radic0.541160.95823&radic&radic&radic&radic&radic S000002189DBP10YDL031WverifiedPutative ATP-dependent RNA helicase of the DEAD-box proteinfamily, constituent of 66S pre-ribosomalparticles; essential protein involved inribosome biogenesis &radic0.589510.95823&radic&radic&radic&radic&radic S000000119MCM2YBL023CverifiedProtein involved in DNA replication; component of the Mcm2-7hexameric complex that binds chromatin as apart of the pre-replicative complex &radic0.634430.95823&radic S000003046DBP3YGL078CverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in ribosomal biogenesis &radic0.590210.95823&radic&radic&radic&radic&radic&radic S000001107RRP3YHR065CverifiedProtein involved in rRNA processing; required for maturation ofthe 35S primary transcript of pre-rRNA and forcleavage leading to mature 18S rRNA; homologousto eIF-4a, which is a DEAD box RNA-dependentATPase with helicase activity &radic0.601240.95823&radic&radic&radic&radic&radic S000006040DBP1YPL119CverifiedPutative ATP-dependent RNA helicase of the DEAD-box proteinfamily; mutants show reduced stability of the40S ribosomal subunit scanning through 5'untranslated regions of mRNAs &radic0.563040.95823&radic&radic&radic&radic&radic S000000758MCM3YEL032WverifiedProtein involved in DNA replication; component of the Mcm2-7hexameric complex that binds chromatin as apart of the pre-replicative complex &radic0.60540.95823 S000000441PRP5YBR237WverifiedRNA helicase in the DEAD-box family, necessary forprespliceosome formation, bridges U1 and U2snRNPs and enables stable U2 snRNP associationwith intron RNA &radic0.587220.95823&radic&radic&radic&radic&radic&radic S000003931DRS1YLL008WverifiedNucleolar DEAD-box protein required for ribosome assembly andfunction, including synthesis of 60S ribosomalsubunits; constituent of 66S pre-ribosomalparticles &radic0.60480.95823&radic&radic&radic&radic&radic&radic S000004264CDC46YLR274WverifiedComponent of the hexameric MCM complex, which is important forpriming origins of DNA replication in G1 andbecomes an active ATP-dependent helicase thatpromotes DNA melting and elongation whenactivated by Cdc7p-Dbf4p in S-phase &radic0.560760.95823 S000003760YJL225CUncharacterizedPutative protein of unknown function; similarity to DNA helicases that are also encoded within subtelomeric Y' elements and induced in telomerase deficient survivors &radic0.520120.95196&radic&radic&radic&radic&radic S000003990YLL067CUncharacterizedPutative protein of unknown function with similarity to helicases &radic0.515480.95157&radic&radic&radic&radic&radic S000004411YLR419WUncharacterizedPutative helicase with limited sequence similarity to human Rb protein; localized to the cytoplasm and the mitochondria; YLR419W is not an essential gene &radic0.511580.95141&radic&radic&radic&radic&radic S000004458YRF1-4YLR466WverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p &radic0.502660.94881&radic&radic&radic&radic&radic S000003528YRF1-3YGR296WverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p &radic0.497590.94666&radic&radic&radic&radic&radic S000003989YLL066CUncharacterizedPutative protein of unknown function with similarity to helicases; YLL066C is not an essential gene &radic0.497640.94666&radic&radic&radic&radic&radic S000004459YRF1-5YLR467WverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p &radic0.496880.94666&radic&radic&radic&radic&radic S000001439YIL177CUncharacterizedPutative protein of unknown function; similarity to DNA helicases that are encoded within subtelomeric Y' elements and induced in telomerase deficient survivors &radic0.494890.94505&radic&radic&radic&radic&radic S000002699HRQ1YDR291WuncharacterizedPutative DNA helicase &radic0.496110.94505&radic&radic&radic&radic&radic&radic S000007526YOR396WUncharacterizedHypothetical protein &radic0.494780.94505&radic&radic&radic&radic&radic S000004602YML133CUncharacterizedPutative protein of unknown function with similarity to helicases; localized to mitochondria; YML133C contains an intron &radic0.482450.94406&radic&radic&radic&radic&radic S000003088PRP43YGL120CverifiedRNA helicase in the DEAH-box family, functions in both RNApolymerase I and polymerase II transcriptmetabolism, involved in release of thelariat-intron from the spliceosome &radic0.475210.94051&radic&radic&radic S000001561DHR2YKL078WverifiedPredominantly nucleolar DEAH-box RNA helicase, required for 18SrRNA synthesis &radic0.466350.93944&radic&radic&radic&radic&radic S000006204YRF1-7YPL283CverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p &radic0.47010.93944&radic&radic&radic&radic&radic S000005283YRF1-6YNL339CverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p &radic0.416820.93469&radic&radic&radic&radic&radic S000002953YRF1-1YDR545WverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p &radic0.451910.93469&radic&radic&radic&radic&radic S000000992YRF1-2YER190WverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p &radic0.445810.93469&radic&radic&radic&radic&radic S000001405SSL2YIL143CverifiedComponent of the holoenzyme form of RNA polymerasetranscription factor TFIIH, has DNA-dependentATPase/helicase activity and is required, withRad3p, for unwinding promoter DNA; involved inDNA repair; homolog of human ERCC3 &radic0.403150.93469&radic&radic&radic&radic S000003220HFM1YGL251CverifiedMeiosis specific DNA helicase involved in the conversion ofdouble-stranded breaks to later recombinationintermediates and in crossover control;catalyzes the unwinding of Holliday junctions;has ssDNA and dsDNA stimulated ATPase activity &radic0.455930.93469&radic&radic&radic&radic&radic S000000973RAD3YER171Wverified5' to 3' DNA helicase, involved in nucleotide excision repairand transcription; subunit of RNA polymerase IItranscription initiation factor TFIIH; subunitof Nucleotide Excision Repair Factor 3 (NEF3);homolog of human XPD protein &radic0.378770.93218&radic S000001828YFL066CUncharacterizedHelicase-like protein encoded within the telomeric Y' element 0.362680.92589&radic&radic&radic&radic&radic S000005950SUV3YPL029WverifiedATP-dependent RNA helicase, component of the mitochondrialdegradosome along with the RNase Dss1p; thedegradosome associates with the ribosome andmediates turnover of aberrant or unprocessedRNAs &radic0.335010.91286&radic&radic&radic S000003118INO80YGL150CverifiedATPase that forms a large complex, containing actin and severalactin-related proteins, that has chromatinremodeling activity and 3' to 5' DNA helicaseactivity in vitro; shows similarity to theSnf2p family of ATPases &radic0.333540.91286&radic&radic&radic&radic&radic&radic&radic S000005294PRP2YNR011CverifiedRNA-dependent ATPase in the DEAH-box family, required foractivation of the spliceosome before the firsttransesterification step in RNA splicing &radic0.333650.91286&radic&radic&radic&radic S000004735ECM16YMR128WverifiedEssential DEAH-box ATP-dependent RNA helicase specific to theU3 snoRNP, predominantly nucleolar indistribution, required for 18S rRNA synthesis &radic0.329470.90808&radic&radic&radic S000000815PRP22YER013WverifiedDEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase,associates with lariat intermediates before thesecond catalytic step of splicing; mediatesATP-dependent mRNA release from the spliceosomeand unwinds RNA duplexes &radic0.326560.90486&radic&radic&radic&radic S000006409YEL077CUncharacterizedHelicase-like protein encoded within the telomeric Y' element &radic0.326160.90476&radic&radic&radic&radic&radic S000000318RAD16YBR114WverifiedProtein that recognizes and binds damaged DNA in anATP-dependent manner (with Rad7p) duringnucleotide excision repair; subunit ofNucleotide Excision Repair Factor 4 (NEF4);member of the SWI/SNF family 0.313970.90031&radic&radic&radic&radic&radic&radic S000001855ACT1YFL039CverifiedActin, structural protein involved in cell polarization,endocytosis, and other cytoskeletal functions 0.313060.89981&radic S000003796RAD26YJR035WverifiedProtein involved in transcription-coupled repair nucleotideexcision repair of UV-induced DNA lesions;homolog of human CSB protein 0.303590.89607&radic&radic&radic&radic&radic&radic S000006408YPR204WUncharacterizedHelicase-like protein encoded within the telomeric Y' element &radic0.302010.89373&radic&radic&radic&radic&radic S000006238ARP7YPR034WverifiedActin-related protein involved in transcriptional regulation;subunit of the chromatin remodeling Snf/Swicomplex 0.294630.8876&radic S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A &radic0.293190.8876&radic&radic&radic&radic&radic&radic S000000449ISW1YBR245CverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPase thatforms a complex with Ioc2p and Ioc4p toregulate transcription elongation, and acomplex with Ioc3p to repress transcriptioninitiation 0.284640.88539&radic&radic&radic&radic&radic&radic&radic S000003628HPR5YJL092WverifiedDNA helicase and DNA-dependent ATPase involved in DNA repair,required for proper timing of commitment tomeiotic recombination and the transition fromMeiosis I to Meiosis II; potential Cdc28psubstrate &radic0.282880.88523&radic&radic S000005816SNF2YOR290CverifiedCatalytic subunit of the SWI/SNF chromatin remodeling complexinvolved in transcriptional regulation;contains DNA-stimulated ATPase activity;functions interdependently in transcriptionalactivation with Snf5p and Snf6p 0.262370.87828&radic&radic&radic&radic&radic&radic&radic S000006156RVB2YPL235WverifiedEssential protein involved in transcription regulation;component of chromatin remodeling complexes;required for assembly and function of the INO80complex; member of the RUVB-like protein family &radic0.250390.87272&radic S000000966CHD1YER164WverifiedNucleosome remodeling factor that functions in regulation oftranscription elongation; contains a chromodomain, a helicase domain and a DNA-bindingdomain; component of both the SAGA and SILKcomplexes 0.249620.87133&radic&radic&radic&radic&radic&radic S000004022RAD5YLR032WverifiedSingle-stranded DNA-dependent ATPase, involved inpostreplication repair; contains RING fingerdomain 0.245990.86759&radic&radic&radic&radic&radic&radic&radic S000006003MOT1YPL082CverifiedEssential abundant protein involved in regulation oftranscription, removes Spt15p (TBP) from DNAvia its C-terminal ATPase activity, forms acomplex with TBP that binds TATA DNA with highaffinity but with altered specificity 0.233620.85876&radic&radic&radic&radic&radic&radic&radic S000003131RAD54YGL163CverifiedDNA-dependent ATPase, stimulates strand exchange by modifyingthe topology of double-stranded DNA; involvedin the recombinational repair of double-strandbreaks in DNA during vegetative growth andmeiosis; member of the SWI/SNF family 0.225020.8518&radic&radic&radic&radic&radic&radic&radic S000002151YBL111CUncharacterizedHelicase-like protein encoded within the telomeric Y' element 0.222840.8498&radic&radic&radic S000005929CHL1YPL008WverifiedConserved nuclear protein required to establishsister-chromatid pairing during S-phase,probable DNA helicase with similarity to humanBACH1, which associates with tumor suppressorBRCA1; associates with acetyltransferase Ctf7p &radic0.192390.81769&radic S000001261YHR218WUncharacterizedHelicase-like protein encoded within the telomeric Y' element 0.179020.80186&radic&radic S000002152YBL112CUncharacterizedPutative protein of unknown function; YBL112C is contained within TEL02L 0.166740.79096&radic&radic S000005743RFC1YOR217WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon 0.165740.78829&radic S000004075ARP6YLR085CverifiedActin-related protein that binds nucleosomes; a component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.163480.78511&radic S000000017FUN30YAL019WverifiedProtein whose overexpression affects chromosome stability,potential Cdc28p substrate; homolog of Snf2p;the authentic, non-tagged protein is detectedin highly purified mitochondria inhigh-throughput studies 0.162250.78317&radic&radic&radic&radic&radic&radic S000002598RVB1YDR190CverifiedEssential protein involved in transcription regulation;component of chromatin remodeling complexes;required for assembly and function of the INO80complex; member of the RUVB-like protein family &radic0.15850.77928&radic S000000277RDH54YBR073WverifiedDNA-dependent ATPase, stimulates strand exchange by modifyingthe topology of double-stranded DNA; involvedin the recombinational repair of double-strandbreaks in DNA during mitosis and meiosis;proposed to be involved in crossoverinterference 0.153620.77381&radic&radic&radic&radic&radic&radic S000005831ISW2YOR304WverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPasecomponent that, with Itc1p, forms a complexrequired for repression of a-specific genes,INO1, and early meiotic genes during mitoticgrowth 0.146870.76299&radic&radic&radic&radic&radic&radic&radic S000001934IRC5YFR038WuncharacterizedPutative ATPase containing the DEAD/H helicase-related sequencemotif; null mutant displays increased levels ofspontaneous Rad52 foci &radic0.145190.76&radic&radic&radic&radic&radic S000001500HCS1YKL017CverifiedHexameric DNA polymerase alpha-associated DNA helicase Ainvolved in lagging strand DNA synthesis;contains single-stranded DNA stimulated ATPaseand dATPase activities; replication protein Astimulates helicase and ATPase activities &radic0.145080.76 S000002187ARP2YDL029WverifiedEssential component of the Arp2/3 complex, which is a highlyconserved actin nucleation center required forthe motility and integrity of actin patches;involved in endocytosis and membrane growth andpolarity 0.141960.7555 S000005667ARP8YOR141CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes &radic0.134850.74407&radic&radic S000004237IRC20YLR247CuncharacterizedPutative helicase; localized to mitochondria and the nucleus;YLR247C is not an essential gene; null mutantdisplays increased levels of spontaneous Rad52foci &radic0.133350.74199&radic&radic&radic&radic&radic&radic S000004636ARP9YMR033WverifiedActin-related protein involved in transcriptional regulation;subunit of the chromatin remodeling Snf/Swicomplex 0.12910.73582 S000002952YDR544CDubiousHypothetical protein 0.128920.73377 S000005281YNL337WDubiousHypothetical protein 0.128920.73377 S000003617ARP4YJL081CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes &radic0.127150.7311&radic&radic S000001388STH1YIL126WverifiedATPase component of the ATP-dependent RSC chromatin remodelingcomplex required for kinetochore function inchromosome segregation; required for expressionof early meiotic genes; essentialhelicase-related protein homologous to Snf2p &radic0.125270.72874&radic&radic&radic&radic&radic&radic S000005455HMI1YOL095CverifiedMitochondrial inner membrane localized ATP-dependent DNAhelicase, required for the maintenance of themitochondrial genome; not required formitochondrial transcription; has homology to E.coli helicase uvrD &radic0.119970.71916 S000002150YBL109WDubiousHypothetical protein 0.11850.71623 S000001042YHL050CUncharacterizedPutative protein of unknown function, potential Cdc28p substrate &radic0.11490.70935&radic&radic S000004685NAM7YMR080CverifiedATP-dependent RNA helicase of the SFI superfamily, required fornonsense mediated mRNA decay and for efficienttranslation termination at nonsense codons;involved in telomere maintenance &radic0.111990.70262 S000003988YLL065WDubiousgrowth inhibitor 0.098320.67973 S000005282YNL338WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV 0.094710.66793 S000000978ECM32YER176WverifiedDNA dependent ATPase/DNA helicase belonging to the Dna2p- andNam7p-like family of helicases that is involvedin modulating translation termination;interacts with the translation terminationfactors, localized to polysomes &radic0.087030.64696 S000004455YLR463CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORFs YLR462W and YLR464W 0.075920.61411 S000004457BSC3YLR465CdubiousDubious open reading frame, unlikely to encode a protein; notconserved in closely related Saccharomycesspecies; 100% of YLR465C overlaps theuncharacterized ORF YLR464W and 86% of YLR465Coverlaps the verified gene YRF1-4 0.075920.61411 S000001133MSR1YHR091CverifiedMitochondrial arginyl-tRNA synthetase 0.066410.58004 S000001171ARP1YHR129CverifiedActin-related protein of the dynactin complex; required forspindle orientation and nuclear migration;putative ortholog of mammalian centractin 0.065430.577 S000005004ARP5YNL059CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes &radic0.063890.57159&radic&radic S000004494RAD52YML032CverifiedProtein that stimulates strand exchange by facilitating Rad51pbinding to single-stranded DNA; annealscomplementary single-stranded DNA; involved inthe repair of double-strand breaks in DNAduring vegetative growth and meiosis 0.062180.56404&radic S000003826ARP3YJR065CverifiedEssential component of the Arp2/3 complex, which is a highlyconserved actin nucleation center required forthe motility and integrity of actin patches;involved in endocytosis and membrane growth andpolarity 0.061140.56176 S000000784PCM1YEL058WverifiedEssential N-acetylglucosamine-phosphate mutase, ahexosephosphate mutase involved in thebiosynthesis of chitin 0.059520.55476&radic S000002951YDR543CDubiousHypothetical protein 0.053660.52762 S000005871TYE7YOR344CverifiedSerine-rich protein that contains a basic-helix-loop-helix(bHLH) DNA binding motif; binds E-boxes ofglycolytic genes and contributes to theiractivation; may function as a transcriptionalactivator in Ty1-mediated gene expression 0.051080.51355&radic S000001069RPN1YHR027CverifiedNon-ATPase base subunit of the 19S regulatory particle of the26S proteasome; may participate in therecognition of several ligands of theproteasome; contains a leucine-rich repeat(LRR) domain, a site for protein?proteininteractions 0.049660.50576&radic S000000065RFA1YAR007CverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 0.047960.49777&radic S000005450MSH2YOL090WverifiedProtein that forms heterodimers with Msh3p and Msh6p that bindto DNA mismatches to initiate the mismatchrepair process; contains a Walker ATP-bindingmotif required for repair activity; Msh2p-Msh6pbinds to and hydrolyzes ATP 0.047680.49643&radic S000002767VID21YDR359CverifiedComponent of the NuA4 histone acetyltransferase complex 0.044050.48165 S000003016RPT6YGL048CverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; bound byubiquitin-protein ligases Ubr1p and Ufd4p;localized mainly to the nucleus throughout thecell cycle 0.045070.48165&radic S000000897RAD51YER095WverifiedStrand exchange protein, forms a helical filament with DNA thatsearches for homology; involved in therecombinational repair of double-strand breaksin DNA during vegetative growth and meiosis;homolog of Dmc1p and bacterial RecA protein 0.043030.47713&radic S000001933RSC8YFR037CverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; essential for viability andmitotic growth; homolog of SWI/SNF subunitSwi3p, but unlike Swi3p, does not activatetranscription of reporters 0.03960.46451&radic&radic S000005162MGS1YNL218WverifiedProtein with DNA-dependent ATPase and ssDNA annealingactivities involved in maintenance of genome;interacts functionally with DNA polymerasedelta; homolog of human Werner helicaseinteracting protein (WHIP) &radic0.03950.464&radic S000000118PIM1YBL022CverifiedMitochondrial ATP-dependent protease involved inintramitochondrial proteolysis; involved indegradation of misfolded proteins inmitochondria; required for bigenesis andmaintenance of mitochondria 0.038570.45954 S000002411RAD57YDR004WverifiedProtein that stimulates strand exchange by stabilizing thebinding of Rad51p to single-stranded DNA;involved in the recombinational repair ofdouble-strand breaks in DNA during vegetativegrowth and meiosis; forms heterodimer withRad55p 0.038210.45822&radic&radic S000002157NHP6BYBR089C-AverifiedHigh-mobility group non-histone chromatin protein, functionallyredundant with Nhp6Ap; homologous to mammalianhigh mobility group proteins 1 and 2; acts torecruit transcription factor Rcs1p to certainpromoters 0.037690.45598&radic S000005845YOR318CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo 0.037290.45377 S000002504MSH6YDR097CverifiedProtein required for mismatch repair in mitosis and meiosis,forms a complex with Msh2p to repair bothsingle-base & insertion-deletion mispairs;potentially phosphorylated by Cdc28p 0.035620.44556&radic S000005558HMS1YOR032CverifiedBasic helix-loop-helix (bHLH) protein with similarity tomyc-family transcription factors;overexpression confers hyperfilamentous growthand suppresses the pseudohyphal filamentationdefect of a diploid mep1 mep2 homozygous nullmutant 0.035440.44465 S000000491ZSP1YBR287WuncharacterizedProtein of unknown function; mutation results in a zincsensitive phenotype 0.035330.44465 S000000291RFC5YBR087WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon 0.033090.43352&radic S000004224TOP3YLR234WverifiedDNA Topoisomerase III, conserved protein that functions in acomplex with Sgs1p and Rmi1p to relaxsingle-stranded negatively-supercoiled DNApreferentially, involved in telomere stabilityand regulation of mitotic recombination 0.033080.43352&radic S000000147PIN4YBL051CverifiedProtein involved in G2/M phase progression and response to DNAdamage, interacts with Rad53p; contains an RNArecognition motif, a nuclear localizationsignal, and several SQ/TQ cluster domains;hyperphosphorylated in response to DNA damage 0.033080.43352 S000002802RPT3YDR394WverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; substrate ofN-acetyltransferase B 0.031940.42819 S000000682CSM1YCR086WverifiedNucleolar protein that forms a complex with Lrs4p which bindsMam1p at kinetochores during meiosis I tomediate accurate chromosome segregation, may beinvolved in premeiotic DNA replication;possible role in telomere maintenance 0.030990.42412 S000005846HSH49YOR319WverifiedU2-snRNP associated splicing factor with similarity to themammalian splicing factor SAP49; proposed tofunction as a U2-snRNP assembly factor alongwith Hsh155p and binding partner Cus1p;contains two RNA recognition motifs (RRM) 0.028680.40929&radic S000005643RPT5YOR117WverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; recruited to theGAL1-10 promoter region upon induction oftranscription 0.029240.40929&radic S000002719TFB1YDR311WverifiedSubunit of TFIIH and nucleotide excision repair factor 3complexes, required for nucleotide excisionrepair, target for transcriptional activators 0.027940.40479&radic S000005527RRP6YOR001WverifiedExonuclease component of the nuclear exosome; contributes tothe quality-control system that retains anddegrades aberrant mRNAs in the nucleus 0.028160.40479&radic S000004683CTF18YMR078CverifiedSubunit of a complex with Ctf8p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion; may have overlappingfunctions with Rad24p in the DNA damagereplication checkpoint 0.027550.40169&radic S000000838ARB1YER036CverifiedATPase of the ATP-binding cassette (ABC) family involved in 40Sand 60S ribosome biogenesis, has similarity toGcn20p; shuttles from nucleus to cytoplasm,physically interacts with Tif6p, Lsg1p 0.027330.39963 S000003730CDC6YJL194WverifiedEssential ATP-binding protein required for DNA replication,component of the pre-replicative complex(pre-RC) which requires ORC to associate withchromatin and is in turn required for Mcm2-7pDNA association; homologous to S. pombe Cdc18p 0.025960.39108&radic S000000702ADH7YCR105WverifiedNADPH-dependent cinnamyl alcohol dehydrogenase family memberwith broad substrate specificity; may beinvolved in fusel alcohol synthesis 0.025750.38911 S000004530ORC1YML065WverifiedLargest subunit of the origin recognition complex, whichdirects DNA replication by binding toreplication origins and is also involved intranscriptional silencing; may bephosphorylated by Cdc28p 0.025790.38911 S000004339KAP95YLR347CverifiedKaryopherin beta, forms a dimeric complex with Srp1p (Kap60p)that mediates nuclear import of cargo proteinsvia a nuclear localization signal (NLS),interacts with nucleoporins to guide transportacross the nuclear pore complex 0.025960.38911 S000000008MDM10YAL010CverifiedSubunit of the mitochondrial sorting and assembly machinery(SAM complex); has a role in assembly of theTOM complex, which mediates protein importthrough the outer membrane; required for normalmitochondrial morphology and inheritance 0.024620.37639 S000003829RFC2YJR068WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon 0.024610.37639&radic S000004777MLH1YMR167WverifiedProtein required for mismatch repair in mitosis and meiosis,postmeiotic segregation, and spore viability;forms a complex with Pms1p and Msh2p to repairmismatched DNA; human homolog is associatedwith hereditary non-polyposis colon cancer 0.023830.37374&radic S000000340MEC1YBR136WverifiedGenome integrity checkpoint protein and PI kinase superfamilymember; signal transducer required for cellcycle arrest and transcriptional responsesprompted by damaged or unreplicated DNA;monitors and participates in meioticrecombination 0.023740.37365 S000004211RSA3YLR221CverifiedProtein with a likely role in ribosomal maturation, requiredfor accumulation of wild-type levels of large(60S) ribosomal subunits; binds to the helicaseDbp6p in pre-60S ribosomal particles in thenucleolus 0.022740.3663 S000001022ECM29YHL030WverifiedMajor component of the proteasome; tethers the proteasome coreparticle to the regulatory particle, andenhances the stability of the proteasome 0.021960.35988&radic S000000849SAP1YER047CverifiedPutative ATPase of the AAA family, interacts with the Sin1ptranscriptional repressor in the two-hybridsystem 0.021650.3569 S000003709RFA3YJL173CverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 0.020390.34643&radic S000004349RSC2YLR357WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; involvedin telomere maintenance 0.020110.34365&radic&radic S000003995SSL1YLR005WverifiedComponent of the core form of RNA polymerase transcriptionfactor TFIIH, which has both protein kinase andDNA-dependent ATPase/helicase activities and isessential for transcription and nucleotideexcision repair; interacts with Tfb4p 0.019740.34096&radic S000001680PEX1YKL197CverifiedAAA-family ATPase peroxin required for peroxisome biogenesis,contains two 230 amino acid ATP-binding AAAcassettes, upregulated in anaerobiosis; Pex1pand Pex6p interact via their N-terminalAAA-cassettes 0.019720.34096 S000000763RAD23YEL037CverifiedProtein with ubiquitin-like N terminus, recognizes and bindsdamaged DNA (with Rad4p) during nucleotideexcision repair; regulates Rad4p levels,subunit of Nuclear Excision Repair Factor 2(NEF2); homolog of human HR23A and HR23Bproteins 0.019540.33959&radic S000002969ERG26YGL001CverifiedC-3 sterol dehydrogenase, catalyzes the second of three stepsrequired to remove two C-4 methyl groups froman intermediate in ergosterol biosynthesis 0.019430.33852 S000003956IRC19YLL033WuncharacterizedPutative protein of unknown function; YLL033W is not anessential gene but mutant is defective in sporeformation; null mutant displays increasedlevels of spontaneous Rad52 foci 0.019410.33852 S000001709VPS1YKR001CverifiedGTPase required for vacuolar protein sorting, functions inactin cytoskeleton organization via itsinteraction with Sla1p; required for lateGolgi-retention of some proteins includingKex2p; involved in regulating peroxisomebiogenesis 0.019290.33745&radic S000004798HSC82YMR186WverifiedCytoplasmic chaperone of the Hsp90 family, redundant infunction and nearly identical with Hsp82p, andtogether they are essential; expressedconstitutively at 10-fold higher basal levelsthat HSP82 and induced 2-3 fold by heat shock 0.019280.33745 S000002552TAF12YDR145WverifiedSubunit (61/68 kDa) of TFIID and SAGA complexes, involved inRNA polymerase II transcription initiation andin chromatin modification, similar to histoneH2A 0.019180.33646&radic S000003957RIX7YLL034CverifiedPutative ATPase of the AAA family, required for export ofpre-ribosomal large subunits from the nucleus;distributed between the nucleolus, nucleoplasm,and nuclear periphery depending on growthconditions &radic0.018880.3342&radic S000005234RFC3YNL290WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon 0.017440.32076&radic S000004420YLR428CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1 0.017460.32076 S000000819AFG3YER017CverifiedComponent, with Yta12p, of the mitochondrial inner membranem-AAA protease that mediates degradation ofmisfolded or unassembled proteins and is alsorequired for correct assembly of mitochondrialenzyme complexes 0.017070.31766 S000004096MDN1YLR106CverifiedHuge dynein-related AAA-type ATPase (midasin), forms extendedpre-60S particle with the Rix1 complex(Rix1p-Ipi1p-Ipi3p), may mediate ATP-dependentremodeling of 60S subunits and subsequentexport from nucleoplasm to cytoplasm 0.017060.31766&radic S000000667IMG2YCR071CverifiedMitochondrial ribosomal protein of the small subunit 0.017030.31751 S000001930PHO4YFR034CverifiedBasic helix-loop-helix (bHLH) transcription factor; bindscooperatively with Pho2p to the PHO5 promoter;function is regulated by phosphorylation atmultiple sites and by phosphate availability 0.016930.31684&radic S000003394TIF4631YGR162WverifiedTranslation initiation factor eIF4G, subunit of the mRNAcap-binding protein complex (eIF4F) that alsocontains eIF4E (Cdc33p); associates with thepoly(A)-binding protein Pab1p, also interactswith eIF4A (Tif1p); homologous to Tif4632p 0.016770.31427 S000002910SAM2YDR502CverifiedS-adenosylmethionine synthetase, catalyzes transfer of theadenosyl group of ATP to the sulfur atom ofmethionine; one of two differentially regulatedisozymes (Sam1p and Sam2p) 0.016520.31278 S000002744YDR336WUncharacterizedPutative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene 0.016410.31161 S000004239YEF3YLR249WverifiedTranslational elongation factor, stimulates the binding ofaminoacyl-tRNA (AA-tRNA) to ribosomes byreleasing EF-1 alpha from the ribosomalcomplex; contains two ABC cassettes; binds andhydrolyses ATP 0.016340.31017 S000002700SRP101YDR292CverifiedSignal recognition particle (SRP) receptor - alpha subunit;contain GTPase domains; involved inSRP-dependent protein targeting; interacts withSRP102p 0.015990.3056 S000004601COS3YML132WverifiedProtein involved in salt resistance; interacts withsodium:hydrogen antiporter Nha1p; member of theDUP380 subfamily of conserved, oftensubtelomerically-encoded proteins 0.015730.30353 S000004847RNH1YMR234WverifiedRibonuclease H1, removes RNA primers during Okazaki fragmentsynthesis; degrades RNA attached to the 5'-endof a DNA strand 0.015840.30353&radic S000000294YBR090CUncharacterizedHypothetical protein 0.015770.30353&radic S000001866CAF16YFL028CverifiedPart of the evolutionarily-conserved CCR4-NOT transcriptionalregulatory complex involved in controlling mRNAinitiation, elongation, and degradation;putative ABC ATPase; interacts with Ssn2p,Ssn3p, and Ssn8p 0.015740.30353&radic S000002814PDR15YDR406WverifiedATP binding cassette (ABC) transporter of the plasma membrane;general stress response factor implicated incellular detoxification; target of Pdr1p, Pdr3pand Pdr8p transcription regulators; promotercontains a PDR responsive element 0.015670.30353 S000005256RFA2YNL312WverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 0.015630.30226&radic S000001905GCN20YFR009WverifiedPositive regulator of the Gcn2p kinase activity, forms acomplex with Gcn1p; proposed to stimulate Gcn2pactivation by an uncharged tRNA 0.01560.30226 S000006406YPR202WUncharacterizedPutative protein of unknown function with similarity to telomere-encoded helicases; YPR202W is not an essential gene; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo 0.015420.3002 S000000637YCR041WDubiousHypothetical protein 0.015490.3002 S000001207DNA2YHR164CverifiedEssential tripartite DNA replication factor withsingle-stranded DNA-dependent ATPase,ATP-dependent nuclease, and helicaseactivities; required for Okazaki fragmentprocessing; involved in DNA repair pathways;potential Cdc28p substrate &radic0.015260.29918&radic S000003949HSP104YLL026WverifiedHeat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p(Hsp70) to refold and reactivate previouslydenatured, aggregated proteins; responsive tostresses including: heat, ethanol, and sodiumarsenite; involved in [PSI+] propagation 0.015140.29715 S000001040COS8YHL048WverifiedNuclear membrane protein, member of the DUP380 subfamily ofconserved, often subtelomerically-encodedproteins; regulation suggests a potential rolein the unfolded protein response 0.015010.29715 S000000636MATALPHA1YCR040WverifiedTranscriptional co-activator involved in regulation ofmating-type-specific gene expression; targetsthe transcription factor Mcm1p to the promotersof alpha-specific genes; one of two genesencoded by the MATalpha mating type cassette 0.014990.29625 S000005850PRO2YOR323CverifiedGamma-glutamyl phosphate reductase, catalyzes the second stepin proline biosynthesis 0.014590.28925&radic S000003805VPS55YJR044CverifiedLate endosomal protein involved in late endosome to vacuoletrafficking; functional homolog of humanobesity receptor gene-related protein (OB-RGRP) 0.014550.28925 S000001948RPN12YFR052WverifiedSubunit of the 19S regulatory particle of the 26S proteasomelid; synthetically lethal with RPT1, which isan ATPase component of the 19S regulatoryparticle; physically interacts with Nob1p andRpn3p 0.014240.28728&radic S000002498RLI1YDR091CverifiedEssential iron-sulfur protein required for ribosome biogenesisand translation initiation; facilitates bindingof a multifactor complex (MFC) of translationinitiation factors to the small ribosomalsubunit; predicted ABC family ATPase 0.014210.28728 S000005280COS1YNL336WverifiedProtein of unknown function, member of the DUP380 subfamily ofconserved, often subtelomerically-encodedproteins 0.014270.28728 S000002384SHS1YDL225WverifiedOne of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p,Shs1p) that form a cortical filamentous collarat the mother-bud neck which is necessary fornormal morphogenesis and cytokinesis 0.014180.28728 S000000261MUM2YBR057CverifiedCytoplasmic protein essential for meiotic DNA replication andsporulation; interacts with Orc2p, which is acomponent of the origin recognition complex 0.014130.28682 S000002783BCS1YDR375CverifiedProtein of the mitochondrial inner membrane that functions asan ATP-dependent chaperone, required for theassembly of the cytochrome bc(1) complex fromthe Rip1p and Qcr10p proteins; member of theCDC48/PAS1/SEC18 ATPase family 0.014050.28601 S000006256NHP6AYPR052CverifiedHigh-mobility group non-histone chromatin protein, functionallyredundant with Nhp6Bp; homologous to mammalianhigh mobility group proteins 1 and 2; acts torecruit transcription factor Rcs1p to certainpromoters 0.013880.28429&radic S000000981DMC1YER179WverifiedMeiosis-specific protein required for repair of double-strandbreaks and pairing between homologouschromosomes; homolog of Rad51p and thebacterial RecA protein 0.014010.28429 S000005787RPN8YOR261CverifiedEssential, non-ATPase regulatory subunit of the 26S proteasome;has similarity to the human p40 proteasomalsubunit and to another S. cerevisiae regulatorysubunit, Rpn11p 0.013830.28351&radic S000005995YTA6YPL074WverifiedPutative ATPase of the CDC48/PAS1/SEC18 (AAA) family, localizedto the cortex of mother cells but not todaughter cells 0.013830.28351 S000001811NFT1YKR103WverifiedPutative transporter of the multidrug resistance-associatedprotein (MRP) subfamily; adjacent ORFs YKR103Wand YKR104W are merged in different strainbackgrounds. 0.013790.28107&radic S000005312YNR029CUncharacterizedHypothetical protein 0.013440.27697 S000006407YPR203WUncharacterizedHypothetical protein 0.013410.27697 S000000635MATALPHA2YCR039CverifiedHomeobox-domain protein that, with Mcm1p, represses a-specificgenes in haploids; acts with A1p to represstranscription of haploid-specific genes indiploids; one of two genes encoded by theMATalpha mating type cassette 0.013530.27697 S000002284CDC48YDL126CverifiedATPase in ER, nuclear membrane and cytosol with homology tomammalian p97; in a complex with Npl4p andUfd1p participates in retrotranslocation ofubiquitinated proteins from the ER into thecytosol for degradation by the proteasome 0.013480.27697&radic S000004389AFG2YLR397CverifiedATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexamericcomplex; may be involved in degradation ofaberrant mRNAs 0.013410.27697 S000001511TFA1YKL028WverifiedTFIIE large subunit, involved in recruitment of RNA polymeraseII to the promoter, activation of TFIIH, andpromoter opening 0.013140.27519&radic S000005785RPT4YOR259CverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; required for spindlepole body duplication; localized mainly to thenucleus throughout the cell cycle 0.013120.27519&radic S000006383HDA3YPR179CverifiedSubunit of a possibly tetrameric trichostatin A-sensitive classII histone deacetylase complex that contains anHda1p homodimer and an Hda2p-Hda3p heterodimer;required for the activity of the complex; hassimilarity to Hda2p 0.01310.27483&radic S000001812YKR104WVerifiedPutative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds 0.013020.27397 S000006260TFB4YPR056WverifiedSubunit of TFIIH complex, involved in transcription initiation,similar to 34 kDa subunit of human TFIIH;interacts with Ssl1p 0.012970.27334&radic S000005679PDR5YOR153WverifiedShort-lived membrane ABC (ATP-binding cassette) transporter,actively exports various drugs, expressionregulated by Pdr1p; also involved in steroidtransport, cation resistance, and cellulardetoxification during exponential growth 0.01290.27231 S000006377VPS4YPR173CverifiedAAA-type ATPase required for efficient late endosome to vacuoletransport; catalyzes the release of anendosomal membrane-associated class E VPSprotein complex; regulates cellular sterolmetabolism; cytoplasmic and endosomallocalization 0.012790.26994 S000004816TOM40YMR203WverifiedComponent of the TOM (translocase of outer membrane) complexresponsible for recognition and initial importsteps for all mitochondrially directedproteins; constitutes the core element of theprotein conducting pore 0.012840.26994 S000000559SPB1YCL054WverifiedAdoMet-dependent methyltransferase involved in rRNA processingand 60S ribosomal subunit maturation;methylates G2922 in the tRNA docking site ofthe large subunit rRNA and in the absence ofsnR52, U2921; suppressor of PAB1 mutants 0.012230.26492 S000005185ZWF1YNL241CverifiedGlucose-6-phosphate dehydrogenase (G6PD), catalyzes the firststep of the pentose phosphate pathway; involvedin adapting to oxidatve stress; homolog of thehuman G6PD which is deficient in patients withhemolytic anemia 0.012230.26492 S000002703HDA2YDR295CverifiedSubunit of a possibly tetrameric trichostatin A-sensitive classII histone deacetylase complex containing anHda1p homodimer and an Hda2p-Hda3p heterodimer;involved in telomere maintenance 0.011950.26147&radic S000003502YTA7YGR270WverifiedProtein of unknown function, member of CDC48/PAS1/SEC18 familyof ATPases, potentially phosphorylated byCdc28p 0.011970.26147&radic S000005313ALG12YNR030WverifiedAlpha-1,6-mannosyltransferase localized to the ER; responsiblefor the addition of the alpha-1,6 mannose todolichol-linked Man7GlcNAc2, acts in thedolichol pathway for N-glycosylation 0.01190.26066 S000002217RAD59YDL059CverifiedProtein involved in the repair of double-strand breaks in DNAduring vegetative growth via recombination andsingle-strand annealing; anneals complementarysingle-stranded DNA; homologous to Rad52p 0.011920.26066&radic S000002764SPC110YDR356WverifiedInner plaque spindle pole body (SPB) component, ortholog ofhuman kendrin; involved in connecting nuclearmicrotubules to SPB; interacts withTub4p-complex and calmodulin; phosphorylated byMps1p in cell cycle-dependent manner 0.011830.2592 S000000605PGK1YCR012Wverified3-phosphoglycerate kinase, catalyzes transfer of high-energyphosphoryl groups from the acyl phosphate of1,3-bisphosphoglycerate to ADP to produce ATP;key enzyme in glycolysis and gluconeogenesis 0.01180.2592&radic S000005454RFC4YOL094CverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon 0.011840.2592&radic S000002243NDE2YDL085WverifiedMitochondrial external NADH dehydrogenase, catalyzes theoxidation of cytosolic NADH; Nde1p and Nde2pare involved in providing the cytosolic NADH tothe mitochondrial respiratory chain 0.011740.25795 S000002344TFP1YDL185WverifiedVacuolar ATPase V1 domain subunit A containing the catalyticnucleotide binding sites; protein precursorundergoes self-catalyzed splicing to yield theextein Tfp1p and the intein Vde (PI-SceI),which is a site-specific endonuclease 0.011720.25795 S000000648RSC6YCR052WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; essential for mitotic growth;homolog of SWI/SNF subunit Swp73p 0.011470.25513&radic S000006166YPL245WUncharacterizedHypothetical protein 0.011450.25513&radic S000006228YME1YPR024WverifiedSubunit, with Mgr1p, of the mitochondrial inner membrane i-AAAprotease complex, which is responsible fordegradation of unfolded or misfoldedmitochondrial gene products; mutation causes anelevated rate of mitochondrial turnover 0.011230.25117 S000003326VAS1YGR094WverifiedMitochondrial and cytoplasmic valyl-tRNA synthetase 0.01130.25117 S000000431MCX1YBR227CverifiedMitochondrial ATP-binding protein, possibly a mitochondrialchaperone with non-proteolytic function;similar to bacterial ClpX proteins 0.011380.25117 S000005442ATG19YOL082WverifiedProtein involved in the cytoplasm-to-vacuole targeting pathwayand in autophagy, recognizes cargo proteins anddelivers them to the preautophagosomalstructure for eventual engulfment by theautophagosome and degradation 0.011350.25117 S000002160NHP10YDL002CverifiedProtein related to mammalian high mobility group proteins;likely component of the INO80 complex, which isan ATP-dependent chromatin-remodeling complex 0.011250.25117&radic&radic S000005477RRI2YOL117WverifiedSubunit of the COP9 signalosome (CSN) complex that cleaves theubiquitin-like protein Nedd8 from SCF ubiquitinligases; plays a role in the mating pheromoneresponse 0.011150.25067 S000005205ORC5YNL261WverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing 0.011080.24916&radic S000005364SIN3YOL004WverifiedComponent of the Sin3p-Rpd3p histone deacetylase complex,involved in transcriptional repression andactivation of diverse processes, includingmating-type switching and meiosis; involved inthe maintenance of chromosomal integrity 0.011080.24916&radic S000004961PUB1YNL016WverifiedPoly(A)+ RNA-binding protein, abundant mRNP-component proteinthat binds mRNA and is required for stabilityof a number of mRNAs; not reported to associatewith polyribosomes 0.010940.24793 S000001832COS4YFL062WverifiedProtein of unknown function, member of the DUP380 subfamily ofconserved, often subtelomerically-encodedproteins 0.011010.24793 S000003017TIF4632YGL049CverifiedTranslation initiation factor eIF4G, subunit of the mRNAcap-binding protein complex (eIF4F) that alsocontains eIF4E (Cdc33p); associates with thepoly(A)-binding protein Pab1p, also interactswith eIF4A (Tif1p); homologous to Tif4631p 0.010990.24793 S000003602MPM1YJL066CverifiedMitochondrial membrane protein of unknown function, contains nohydrophobic stretches 0.010910.247 S000005273PEX6YNL329CverifiedPeroxisomal membrane AAA-family ATPase peroxin required forperoxisome assembly, contains two 230 aminoacid ATP-binding AAA cassettes, interacts withPex1p 0.010780.24542 S000005435YOL075CUncharacterizedHypothetical protein 0.010720.24488 S000003927ORC3YLL004WverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing 0.010720.24488 S000000633PHO87YCR037CverifiedLow-affinity inorganic phosphate (Pi) transporter, involved inactivation of PHO pathway; expression isindependent of Pi concentration and Pho4pactivity; contains 12 membrane-spanningsegments 0.010660.24336 S000004695YTA12YMR089CverifiedComponent, with Afg3p, of the mitochondrial inner membranem-AAA protease that mediates degradation ofmisfolded or unassembled proteins and is alsorequired for correct assembly of mitochondrialenzyme complexes 0.010450.24093 S000001164YHR122WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; may be involved in transcription; YHR122W is an essential gene 0.010040.23472 S000006434LSM3YLR438C-AverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.010160.23472&radic S000000284SEC18YBR080CverifiedATPase required for the release of Sec17p during the 'priming'step in homotypic vacuole fusion and for ER toGolgi transport; homolog of the mammalian NSF 0.010010.23407 S000001160ORC6YHR118CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing; may be phosphorylated by Cdc28p 0.009970.23286&radic S000003922COS5YJR161CverifiedProtein of unknown function, member the DUP380 subfamily ofconserved, often subtelomerically-encodedproteins 0.009970.23286 S000001807BAS1YKR099WverifiedMyb-related transcription factor involved in regulating basaland induced expression of genes of the purineand histidine biosynthesis pathways 0.00990.23225&radic S000002165RPT2YDL007WverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; required for normalpeptide hydrolysis by the core 20S particle 0.00980.23051 S000004959HEF3YNL014WverifiedTranslational elongation factor EF-3; paralog of YEF3 andmember of the ABC superfamily; stimulates EF-1alpha-dependent binding of aminoacyl-tRNA bythe ribosome; normally expressed in zincdeficient cells 0.009820.23051 S000002578HSP42YDR171WverifiedSmall cytosolic stress-induced chaperone that formsbarrel-shaped oligomers and suppresses theaggregation of non-native proteins; oligomerdissociation is not required for function;involved in cytoskeleton reorganization afterheat shock 0.00980.23051 S000002907LCD1YDR499WverifiedEssential protein required for the DNA integrity checkpointpathways; interacts physically with Mec1p;putative homolog of S. pombe Rad26 and humanATRIP 0.009670.22804&radic S000000894IES5YER092WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.009640.2279&radic&radic S000005621RKI1YOR095CverifiedRibose-5-phosphate ketol-isomerase, catalyzes theinterconversion of ribose 5-phosphate andribulose 5-phosphate in the pentose phosphatepathway; participates in pyridoxinebiosynthesis 0.009630.22785&radic S000003882ATP2YJR121WverifiedBeta subunit of the F1 sector of mitochondrial F1F0 ATPsynthase, which is a large, evolutionarilyconserved enzyme complex required for ATPsynthesis 0.009550.22647 S000001275PDR11YIL013CverifiedMembrane protein of the ATP-binding cassette (ABC) transportersuperfamily, involved in multiple drugresistance, mediates sterol uptake when sterolbiosynthesis is compromised, regulated byPdr1p, required for anaerobic growth 0.009360.22348 S000004021YLR031WUncharacterizedHypothetical protein 0.009330.22287 S000003778ESS1YJR017CverifiedPeptidylprolyl-cis/trans-isomerase (PPIase) specific forphosphorylated serine and threonine residuesN-terminal to proline; regulatesphosphorylation of the RNA polymerase II largesubunit (Rpo21p) C-terminal domain 0.009190.22059&radic S000001243RPN10YHR200WverifiedNon-ATPase base subunit of the 19S regulatory particle (RP) ofthe 26S proteasome; N-terminus plays a role inmaintaining the structural integrity of the RP;binds selectively to polyubiquitin chains;homolog of the mammalian S5a protein 0.009220.22059&radic S000005922HAT1YPL001WverifiedCatalytic subunit of the Hat1p-Hat2p histone acetyltransferasecomplex that uses the cofactor acetyl coenzymeA, to acetylate free nuclear and cytoplasmichistone H4; involved in telomeric silencing andDNA double-strand break repair 0.00910.21882 S000003260MSP1YGR028WverifiedMitochondrial protein involved in sorting of proteins in themitochondria; putative membrane-spanning ATPase 0.009120.21882 S000001628RPT1YKL145WverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; required for optimalCDC20 transcription; interacts with Rpn12p andthe E3 ubiquitin-protein ligase Ubr1p 0.009050.21791&radic S000000991YER189WUncharacterizedHypothetical protein 0.009040.21633 S000004844PEP5YMR231WverifiedPeripheral vacuolar membrane protein required for proteintrafficking and vacuole biogenesis; formscomplex with Pep3p that promotes vesiculardocking/fusion reactions in conjunction withSNARE proteins, also interacts with Pep7p 0.008990.21633 S000000604ADP1YCR011CverifiedPutative ATP-dependent permease of the ABC transporter familyof proteins 0.008930.21542 S000000704AAD3YCR107WverifiedPutative aryl-alcohol dehydrogenase with similarity to P.chrysosporium aryl-alcohol dehydrogenase;mutational analysis has not yet revealed aphysiological role 0.008710.21024 S000005372HTZ1YOL012CverifiedHistone variant H2AZ, exchanged for histone H2A in nucleosomesby the SWR1 complex; involved intranscriptional regulation through preventionof the spread of silent heterochromatin 0.008670.21024&radic&radic S000000570YCL065WDubiousHypothetical protein 0.008720.21024 S000002330GLT1YDL171CverifiedNAD(+)-dependent glutamate synthase (GOGAT), synthesizesglutamate from glutamine andalpha-ketoglutarate; with Gln1p, forms thesecondary pathway for glutamate biosynthesisfrom ammonia; expression regulated by nitrogensource 0.008610.20969 S000001671PXA2YKL188CverifiedSubunit of a heterodimeric peroxisomal ATP-binding cassettetransporter complex (Pxa1p-Pxa2p), required forimport of long-chain fatty acids intoperoxisomes; similarity to humanadrenoleukodystrophy transporter andALD-related proteins 0.008560.20873 S000000823RPN3YER021WverifiedEssential, non-ATPase regulatory subunit of the 26S proteasomelid, similar to the p58 subunit of the human26S proteasome; temperature-sensitive allelescause metaphase arrest, suggesting a role forthe proteasome in cell cycle control 0.008460.20686&radic S000006191MDL2YPL270WverifiedHalf-type ATP-binding cassette (ABC) transporter of the innermitochondrial membrane 0.008410.20607 S000000229YBR025CUncharacterizedHypothetical protein 0.008440.20607 S000006111NAB3YPL190CverifiedSingle stranded DNA binding protein; acidic ribonucleoprotein;required for termination of non-poly(A)transcripts and efficient splicing; interactswith Nrd1p 0.008230.20284&radic S000002786LSM6YDR378CverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.008160.20192&radic S000000535HIS4YCL030CverifiedMultifunctional enzyme containing phosphoribosyl-ATPpyrophosphatase, phosphoribosyl-AMPcyclohydrolase, and histidinol dehydrogenaseactivities; catalyzes the second, third, ninthand tenth steps in histidine biosynthesis 0.008160.20192 S000001692STE6YKL209CverifiedATP-binding cassette (ABC) transporter required for the exportof a-factor, catalyzes ATP hydrolysis coupledto a-factor transport, contains 12transmembrane domains and two ATP bindingdomains, expressed only in MATa cells 0.008160.20192 S000001881IES1YFL013CverifiedSubunit of the INO80 chromatin remodeling complex 0.00810.20061&radic&radic S000000264ORC2YBR060CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing; may be phosphorylated by Cdc28p 0.007990.19915&radic S000002666HSP78YDR258CverifiedOligomeric mitochondrial matrix chaperone that cooperates withSsc1p in mitochondrial thermotolerance afterheat shock; prevents the aggregation ofmisfolded matrix proteins; component of themitochondrial proteolysis system 0.007940.19862 S000005026PMS1YNL082WverifiedATP-binding protein required for mismatch repair in mitosis andmeiosis; functions as a heterodimer with Mlh1p,binds double- and single-stranded DNA via itsN-terminal domain, similar to E. coli MutL 0.007970.19862&radic S000002468YDR061WUncharacterizedMitochondrial protein, member of the ATP-binding cassette (ABC) transporter family; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance 0.007950.19862 S000005485TRM13YOL125WuncharacterizedHypothetical protein 0.007940.19861&radic S000004178MDL1YLR188WverifiedHalf-type ATP-binding cassette (ABC) transporter of the innermitochondrial membrane, mediates export ofpeptides generated upon proteolysis ofmitochondrial proteins, plays a role in theregulation of cellular resistance to oxidativestress 0.007920.198 S000003971YBT1YLL048CverifiedTransporter of the ATP-binding cassette (ABC) family involvedin bile acid transport; similar to mammalianbile transporters 0.007920.198 S000005353YNR070WUncharacterizedPutative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance 0.007840.19683 S000006068PXA1YPL147WverifiedSubunit of a heterodimeric peroxisomal ATP-binding cassettetransporter complex (Pxa1p-Pxa2p), required forimport of long-chain fatty acids intoperoxisomes; similarity to humanadrenoleukodystrophy transporter andALD-related proteins 0.007740.19466 S000000688MSH3YCR092CverifiedMismatch repair protein, forms dimers with Msh2p that mediaterepair of insertion or deletion mutations andremoval of nonhomologous DNA ends, contains aPCNA (Pol30p) binding motif required for genomestability 0.007710.19463&radic S000003938BPT1YLL015WverifiedABC type transmembrane transporter of MRP/CFTR family, found invacuolar membrane, involved in the transport ofunconjugated bilirubin and in heavy metaldetoxification via glutathione conjugates,along with Ycf1p 0.007680.1942 S000000393RPS9BYBR189WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps9Ap and has similarity to E.coli S4 and rat S9 ribosomal proteins 0.007620.19301 S000006230ATH1YPR026WverifiedAcid trehalase required for utilization of extracellulartrehalose 0.007530.19111 S000001716RSC4YKR008WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; found in close proximity tonucleosomal DNA; displaced from the surface ofnucleosomal DNA after chromatin remodeling 0.007470.19046&radic&radic S000000964RAD4YER162CverifiedProtein that recognizes and binds damaged DNA (with Rad23p)during nucleotide excision repair; subunit ofNuclear Excision Repair Factor 2 (NEF2);homolog of human XPC protein 0.007460.19018&radic S000001381RPI1YIL119CverifiedPutative transcriptional regulator; overexpression suppressesthe heat shock sensitivity of wild-type RAS2overexpression and also suppresses the celllysis defect of an mpk1 mutation 0.007450.19018&radic S000002835RPN9YDR427WverifiedNon-ATPase regulatory subunit of the 26S proteasome, hassimilarity to putative proteasomal subunits inother species; null mutant is temperaturesensitive and exhibits cell cycle andproteasome assembly defects 0.00740.18924&radic S000004916ATM1YMR301CverifiedMitochondrial inner membrane transporter, exportsmitochondrially synthesized precursors ofiron-sulfur (Fe/S) clusters to the cytosol;member of the ATP-binding cassette (ABC)transporter family 0.007310.18734 S000002418SNQ2YDR011WverifiedABC transporter protein involved in multidrug resistance andresistance to singlet oxygen species 0.007260.18582 S000001027VMR1YHL035CverifiedProtein of unknown function that may interact with ribosomes,based on co-purification experiments; member ofthe ATP-binding cassette (ABC) family;potential Cdc28p substrate; detected inpurified mitochondria in high-throughputstudies 0.007260.18582 S000001762DYN1YKR054CverifiedCytoplasmic heavy chain dynein, microtubule motor protein,required for anaphase spindle elongation;involved in spindle assembly, chromosomemovement, and spindle orientation during celldivision, targeted to microtubule tips by Pac1p 0.007080.18314 S000006147NEW1YPL226WverifiedATP binding cassette family member; Asn/Gln-rich rich regionsupports [NU+] prion formation, susceptibilityto [PSI+] prion induction and aggregation of afragment of the human Machado-Joseph Diseaseprotein 0.007050.18264 S000003959PRP19YLL036CverifiedSplicing factor associated with the spliceosome; contains aU-box, a motif found in a class of ubiquitinligases 0.007030.18219&radic S000002745MRPS28YDR337WverifiedMitochondrial ribosomal protein of the small subunit 0.007020.18177 S000000683YCR087WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene 0.006990.18016 S000000183RPL23AYBL087CverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl23Bp and has similarity to E.coli L14 and rat L23 ribosomal proteins 0.006980.18016&radic S000000572HMLALPHA2YCL067CverifiedSilenced copy of ALPHA2 at HML; homeobox-domain protein thatassociates with Mcm1p in haploid cells torepress a-specific gene expression andinteracts with a1p in diploid cells to represshaploid-specific gene expression 0.0070.18016 S000006172YPL251WDubiousHypothetical protein; open reading frame overlaps 5' end of essential YAH1 gene required for iron-sulfur protein biogenesis 0.00690.17959 S000001909IOC3YFR013WverifiedMember of a complex (Isw1a) with Isw1p that hasnucleosome-stimulated ATPase activity andrepresses transcription initiation by specificpositioning of a promoter proximaldinucleosome; has homology to Esc8p, which isinvolved in silencing 0.006840.17829&radic&radic S000003548RPC17YJL011CverifiedRNA polymerase III subunit C17; physically interacts with C31,C11, and TFIIIB70; may be involved in therecruitment of pol III by the preinitiationcomplex 0.006840.17829&radic S000004732STO1YMR125WverifiedLarge subunit of the nuclear mRNA cap-binding protein complex,interacts with Npl3p to carry nuclear poly(A)+mRNA to cytoplasm; also involved in nuclearmRNA degradation and telomere maintenance;orthologous to mammalian CBP80 0.006830.17829&radic S000000302MMS4YBR098WverifiedSubunit of the structure-specific Mms4p-Mus81p endonucleasethat cleaves branched DNA; involved inrecombination and DNA repair 0.006840.17829&radic S000006314RPC40YPR110CverifiedRNA polymerase subunit, common to RNA polymerase I and III 0.006810.17733&radic&radic S000002315YDL156WUncharacterizedHypothetical protein 0.006760.17666&radic S000002398ADY3YDL239CverifiedProtein required for spore wall formation, thought to mediateassembly of a Don1p-containing structure at theleading edge of the prospore membrane viainteraction with spindle pole body components;potentially phosphorylated by Cdc28p 0.006750.17666 S000000571HMLALPHA1YCL066WverifiedSilenced copy of ALPHA1 at HML, encoding a transcriptionalcoactivator involved in the regulation ofmating-type alpha-specific gene expression 0.006730.17605 S000005855PDR10YOR328WverifiedABC (ATP-binding cassette) membrane pump involved in thepleiotropic drug resistance network, regulatedby Pdr1p and Pdr3p, similar to Pdr5p 0.006710.1755 S000005060DMA2YNL116WverifiedProtein involved in regulating spindle position andorientation, functionally redundant with Dma1p;homolog of S. pombe Dma1 and H. sapiens Chfr 0.006680.1752 S000003224ZRT1YGL255WverifiedHigh-affinity zinc transporter of the plasma membrane,responsible for the majority of zinc uptake;transcription is induced under low-zincconditions by the Zap1p transcription factor 0.006570.17302 S000000122LSM2YBL026WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.006670.17302&radic S000004137SMD3YLR147CverifiedCore Sm protein Sm D3; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D3 0.006580.17302 S000005335POP2YNR052CverifiedRNase of the DEDD superfamily, subunit of the Ccr4-Not complexthat mediates 3' to 5' mRNA deadenylation 0.006550.1724&radic S000002840NPL3YDR432WverifiedRNA-binding protein that carries poly(A)+ mRNA from the nucleusinto the cytoplasm; phosphorylation by Sky1p inthe cytoplasm may promote release of mRNAs 0.006520.17149&radic S000004071GAL2YLR081WverifiedGalactose permease, required for utilization of galactose; alsoable to transport glucose 0.006470.17044 S000003660LSM1YJL124CverifiedLsm (Like Sm) protein; forms heteroheptameric complex (withLsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p)involved in degradation of cytoplasmic mRNAs 0.006480.17044&radic S000006292SRP54YPR088CverifiedSignal recognition particle (SRP) subunit (homolog of mammalianSRP54); contains the signal sequence-bindingactivity of SRP, interacts with the SRP RNA,and mediates binding of SRP to signal receptor;contains GTPase domain 0.006470.17044 S000002484SED1YDR077WverifiedMajor stress-induced structural GPI-cell wall glycoprotein instationary-phase cells, associates withtranslating ribosomes, possible role inmitochondrial genome maintenance; ORF containstwo distinct variable minisatellites 0.006410.16989 S000004093CDC45YLR103CverifiedDNA replication initiation factor; recruited to MCM pre-RCcomplexes at replication origins; promotesrelease of MCM from Mcm10p, recruits elongationmachinery; mutants in human homolog may causevelocardiofacial and DiGeorge syndromes 0.006410.16913&radic S000005351YNR068CUncharacterizedHypothetical protein 0.006340.1685 S000001019RIM101YHL027WverifiedTranscriptional repressor involved in response to pH and incell wall construction; required for alkalinepH-stimulated haploid invasive growth andsporulation; activated by proteolyticprocessing; similar to A. nidulans PacC 0.00630.16738 S000002416GAL3YDR009WverifiedTranscriptional regulator involved in activation of the GALgenes in response to galactose; forms a complexwith Gal80p to relieve Gal80p inhibition ofGal4p; binds galactose and ATP but does nothave galactokinase activity 0.006240.16627 S000003905MGM101YJR144WverifiedProtein involved in mitochondrial genome maintenance; componentof the mitochondrial nucleoid, required for therepair of oxidative mtDNA damage 0.006240.16627 S000004658STV1YMR054WverifiedSubunit of vacuolar-ATPase V0 domain, one of two isoforms(Stv1p and Vph1p); Stv1p is located in V-ATPasecomplexes of the Golgi and endosomes whileVph1p is located in V-ATPase complexes of thevacuole 0.006160.16432 S000002774YDR366CUncharacterizedHypothetical protein 0.006070.16123 S000000847ACA1YER045CverifiedBasic leucine zipper (bZIP) transcription factor of theATF/CREB family, may regulate transcription ofgenes involved in utilization of non-optimalcarbon sources 0.006070.16123 S000003513YOR1YGR281WverifiedPlasma membrane transporter of the ATP-binding cassette (ABC)family, mediates export of many differentorganic anions including oligomycin 0.006120.16123 S000002776YPR1YDR368Wverified2-methylbutyraldehyde reductase, may be involved in isoleucinecatabolism 0.006050.16123&radic S000002240RPL13AYDL082WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl13Bp; not essential forviability; has similarity to rat L13 ribosomalprotein 0.006020.16099 S000003207CSE1YGL238WverifiedNuclear envelope protein that mediates the nuclear export ofimportin alpha (Srp1p), homolog of metazoan CASprotein, required for accurate chromosomesegregation 0.006020.16099&radic S000005377ESC8YOL017WverifiedProtein involved in telomeric and mating-type locus silencing,interacts with Sir2p and also interacts withthe Gal11p, which is a component of the RNA polII mediator complex 0.0060.16031&radic&radic S000006174VIK1YPL253CverifiedProtein that forms a complex with Kar3p at the spindle polebody, possible regulator of Kar3p function inmicrotubule-mediated processes; required forsister chromatid cohesion; has similarity toCik1p 0.005980.16025 S000004650NUP116YMR047CverifiedSubunit of the nuclear pore complex (NPC) that is localized toboth sides of the pore; contains a repetitiveGLFG motif that interacts with mRNA exportfactor Mex67p and with karyopherin Kap95p;homologous to Nup100p 0.005960.15958&radic S000002255RPN6YDL097CverifiedEssential, non-ATPase regulatory subunit of the 26S proteasomelid required for the assembly and activity ofthe 26S proteasome; the human homolog (S9protein) partially rescues Rpn6p depletion 0.005930.15814&radic S000004515GAL80YML051WverifiedTranscriptional regulator involved in the repression of GALgenes in the absence of galactose; inhibitstranscriptional activation by Gal4p; inhibitionrelieved by Gal3p or Gal1p binding 0.00590.15796&radic S000001586LAP4YKL103CverifiedVacuolar aminopeptidase, often used as a marker protein instudies of autophagy and cytosol to vacuoletargeting (CVT) pathway 0.005860.15708 S000004657STB2YMR053CverifiedProtein that interacts with Sin3p in a two-hybrid assay and ispart of a large protein complex with Sin3p andStb1p 0.005860.15708 S000001208PRP8YHR165CverifiedComponent of the U4/U6-U5 snRNP complex, involved in the secondcatalytic step of splicing 0.005840.15669&radic S000004897YKU70YMR284WverifiedSubunit of the telomeric Ku complex (Yku70p-Yku80p), involvedin telomere length maintenance, structure andtelomere position effect; relocates to sites ofdouble-strand cleavage to promote nonhomologousend joining during DSB repair 0.005830.15654&radic S000000222GAL7YBR018CverifiedGalactose-1-phosphate uridyl transferase, synthesizesglucose-1-phosphate and UDP-galactose fromUDP-D-glucose and alpha-D-galactose-1-phosphatein the second step of galactose catabolism 0.00580.15567 S000000998SHU1YHL006CuncharacterizedProtein of unassigned function involved in mutationsuppression, important for error-free repair ofspontaneous and induced DNA lesions to protectthe genome from mutation; associates withShu2p, Psy3p, and Csm2p 0.005730.15421 S000000390PCH2YBR186WverifiedNucleolar component of the pachytene checkpoint, which preventschromosome segregation when recombination andchromosome synapsis are defective; alsorepresses meiotic interhomolog recombination inthe rDNA 0.005630.15084 S000000752SNU13YEL026WverifiedRNA binding protein, part of U3 snoRNP involved in rRNAprocessing, part of U4/U6-U5 tri-snRNP involvedin mRNA splicing, similar to human 15.5Kprotein 0.005620.15084 S000002722RAD34YDR314CverifiedProtein involved in nucleotide excision repair (NER);homologous to RAD4 0.005610.15084&radic S000004846YMR233WUncharacterizedProtein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; YMR233W is not an essential gene 0.005590.15009&radic S000006386SMX3YPR182WverifiedCore Sm protein Sm F; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm F 0.005560.14999&radic S000003427SKI6YGR195Wverified3'-to-5' phosphorolytic exoribonuclease that is a subunit ofthe exosome; required for 3' processing of the5.8S rRNA; involved in 3' to 5' mRNAdegradation and translation inhibition ofnon-poly(A) mRNAs 0.005540.14922&radic S000001656SNU114YKL173WverifiedGTPase component of U5 snRNP involved in mRNA splicing viaspliceosome; binds directly to U5 snRNA;proposed to be involved in conformationalchanges of the spliceosome; similarity toribosomal translocation factor EF-2 0.005530.14922&radic S000005955YPL034WUncharacterizedHypothetical protein 0.005530.14922 S000005051YAF9YNL107WverifiedSubunit of both the NuA4 histone H4 acetyltransferase complexand the SWR1 complex, may function toantagonize silencing near telomeres; interactsdirectly with Swc4p, has homology to humanleukemogenic protein AF9, contains a YEATSdomain 0.005530.14922&radic S000004966HDA1YNL021WverifiedPutative catalytic subunit of a class II histone deacetylasecomplex that also contains Hda2p and Hda3p;Hda1p interacts with the Hda2p-Hda3p subcomplexto form an active tetramer; deletion increaseshistone H2B, H3 and H4 acetylation 0.00550.1479&radic S000005195NRD1YNL251CverifiedRNA-binding protein that interacts with the C-terminal domainof the RNA polymerase II large subunit(Rpo21p), required for transcriptiontermination and 3' end maturation ofnonpolyadenylated RNAs 0.005520.1479&radic S000001073RRM3YHR031CverifiedDNA helicase involved in rDNA replication and Ty1transposition; relieves replication fork pausesat telomeric regions; structurally andfunctionally related to Pif1p &radic0.005470.14757&radic S000000914LSM4YER112WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.005470.14757&radic S000003910YJR149WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.005460.14592 S000005943RAD1YPL022WverifiedSingle-stranded DNA endonuclease (with Rad10p), cleavessingle-stranded DNA during nucleotide excisionrepair and double-strand break repair; subunitof Nucleotide Excision Repair Factor 1 (NEF1);homolog of human XPF protein 0.005410.14592&radic S000003726RPS22AYJL190CverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps22Bp and has similarity to E.coli S8 and rat S15a ribosomal proteins 0.005360.14468&radic S000006240VMA13YPR036WverifiedSubunit H of the eight-subunit V1 peripheral membrane domain ofthe vacuolar H+-ATPase (V-ATPase), anelectrogenic proton pump found throughout theendomembrane system; serves as an activator ora structural stabilizer of the V-ATPase 0.005360.14468 S000005642RPO31YOR116CverifiedRNA polymerase III subunit C160, part of core enzyme; similarto bacterial beta-prime subunit 0.005330.14409&radic S000000619PMP1YCR024C-AverifiedSmall single-membrane span proteolipid that functions as aregulatory subunit of the plasma membraneH(+)-ATPase Pma1p, forms unique helix andpositively charged cytoplasmic domain that isable to specifically segregatephosphatidylserines 0.005320.14322 S000006236SRO7YPR032WverifiedPutative effector of Rab GTPase Sec4p, forms a complex withSec4p and t-SNARE Sec9p; involved in exocytosisand docking and fusion of post-Golgi vesicleswith plasma membrane; homolog of Sro77p andDrosophila lgl tumor suppressor 0.00530.14322 S000004853CUS1YMR240CverifiedProtein required for assembly of U2 snRNP into the spliceosome,forms a complex with Hsh49p and Hsh155p 0.005310.14322&radic S000005083RLR1YNL139CverifiedSubunit of the THO complex, which is required for efficienttranscription elongation and involved intranscriptional elongation-associatedrecombination; required for LacZ RNA expressionfrom certain plasmids 0.005310.14322&radic&radic S000005770ESA1YOR244WverifiedHistone acetyltransferase catalytic subunit of the nativemultisubunit complex (NuA4) that acetylatesfour conserved internal lysines of histone H4N-terminal tail; required for cell cycleprogression 0.005280.14244&radic S000004023RSC58YLR033WverifiedRemodels the structure of chromatin complex 58KDa subunit;Chromatin Remodeling Complex subunit 0.005280.14244&radic&radic S000005835SNU66YOR308CverifiedComponent of the U4/U6.U5 snRNP complex involved in pre-mRNAsplicing via spliceosome; has homology to humanSART-1 and to an S. pombe protein; snu66 nullmutation confers cold-sensitivity but is notlethal at normal growth temperatures 0.005290.14244&radic S000002711RSC3YDR303CverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; essential gene required forregulation of ribosomal protein genes and thecell wall/stress response; highly similar toRsc30p 0.005260.14218&radic S000000673PAT1YCR077CverifiedTopoisomerase II-associated deadenylation-dependentmRNA-decapping factor; also required forfaithful chromosome transmission, maintenanceof rDNA locus stability, and protection of mRNA3'-UTRs from trimming; functionally linked toPab1p 0.005250.14178&radic S000001949HXK1YFR053CverifiedHexokinase isoenzyme 1, a cytosolic protein that catalyzesphosphorylation of glucose during glucosemetabolism; expression is highest during growthon non-glucose carbon sources; glucose-inducedrepression involves the hexokinase Hxk2p 0.005240.14162 S000000252RPS11BYBR048WverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps11Ap and has similarity to E.coli S17 and rat S11 ribosomal proteins 0.00520.14033 S000000831SMB1YER029CverifiedCore Sm protein Sm B; part of heteroheptameric complex (withSmd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm B and Sm B' 0.005170.13984&radic S000005537AUS1YOR011WverifiedTransporter of the ATP-binding cassette family, involved inuptake of sterols and anaerobic growth 0.005170.13984 S000005206POL2YNL262WverifiedCatalytic subunit of DNA polymerase epsilon, one of the majorchromosomal DNA replication polymerasescharacterized by processivity and proofreadingexonuclease activity; also involved in DNAsynthesis during DNA repair 0.005150.13915&radic S000002625RAD9YDR217CverifiedDNA damage-dependent checkpoint protein, required forcell-cycle arrest in G1/S, intra-S, and G2/M;transmits checkpoint signal by activatingRad53p and Chk1p; hyperphosphorylated by Mec1pand Tel1p; potential Cdc28p substrate 0.005120.13718&radic S000003026RAD6YGL058WverifiedUbiquitin-conjugating enzyme (E2), involved in postreplicationrepair (with Rad18p), sporulation, telomeresilencing, and ubiquitin-mediated N-end ruleprotein degradation (with Ubr1p) 0.005080.13718&radic&radic S000002229IRC1YDL071CdubiousHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 0.00510.13718 S000002226YDL068WDubiousHypothetical protein 0.005110.13718 S000002881PRP3YDR473CverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.005050.13624&radic S000003335NOP7YGR103WverifiedNucleolar protein involved in rRNA processing and 60S ribosomalsubunit biogenesis; constituent of severaldifferent pre-ribosomal particles; required forexit from G0 and the initiation ofcell proliferation 0.005030.13534&radic S000003323PRP31YGR091WverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.005020.13534&radic S000001926MET10YFR030WverifiedSubunit alpha of assimilatory sulfite reductase, which isresponsible for the conversion of sulfite intosulfide 0.005010.13511 S000000613PET18YCR020CverifiedProtein required for respiratory growth and stability of themitochondrial genome 0.004990.13433 S000002545HPR1YDR138WverifiedSubunit of THO/TREX complexes that couple transcriptionelongation with mitotic recombination and withmRNA metabolism and export, subunit of an RNAPol II complex; regulates lifespan; involved intelomere maintenance; similar to Top1p 0.0050.13433&radic&radic S000005091LSM7YNL147WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.005010.13433 S000002259DUN1YDL101CverifiedCell-cycle checkpoint serine-threonine kinase required for DNAdamage-induced transcription of certain targetgenes, phosphorylation of Rad55p and Sml1p, andtransient G2/M arrest after DNA damage; alsoregulates postreplicative DNA repair 0.004980.13416&radic&radic S000000975RAD24YER173WverifiedCheckpoint protein, involved in the activation of the DNAdamage and meiotic pachytene checkpoints;subunit of a clamp loader that loadsRad17p-Mec3p-Ddc1p onto DNA; homolog of humanand S. pombe Rad17 protein 0.004980.13416&radic S000000221KAP104YBR017CverifiedTransportin, cytosolic karyopherin beta 2 involved in deliveryof heterogeneous nuclear ribonucleoproteins tothe nucleoplasm, binds rg-nuclear localizationsignals on Nab2p and Hrp1p, plays a role incell-cycle progression 0.004970.13329&radic S000006382PRP4YPR178WverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.004910.13197&radic S000005670ELG1YOR144CverifiedProtein required for S phase progression and telomerehomeostasis, forms an alternative replicationfactor C complex important for DNA replicationand genome integrity; involved in homologousrecombination-mediated DNA repair 0.004910.13197&radic S000004335GAS2YLR343WuncharacterizedPutative 1,3-beta-glucanosyltransferase, has similarity toGas1p 0.004920.13197 S000003783LSM8YJR022WverifiedLsm (Like Sm) protein; forms heteroheptameric complex (withLsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p)that is part of spliceosomal U6 snRNP and isalso implicated in processing of pre-tRNA,pre-snoRNA, and pre-rRNA 0.004880.13141&radic S000002415YDR008CDubiousHypothetical protein 0.004880.13122 S000002789YRA1YDR381WverifiedNuclear protein that binds to RNA and to Mex67p, required forexport of poly(A)+ mRNA from the nucleus;member of the REF (RNA and export factorbinding proteins) family; another familymember, Yra2p, can substitute for Yra1pfunction 0.004870.13122&radic S000006229CCL1YPR025CverifiedCyclin associated with protein kinase Kin28p, which is theTFIIH-associated carboxy-terminal domain (CTD)kinase involved in transcription initiation atRNA polymerase II promoters 0.004840.12939&radic S000002256SNU23YDL098CverifiedComponent of U4/U6.U5 snRNP involved in mRNA splicing viaspliceosome 0.004810.12939&radic S000003490RAD2YGR258CverifiedSingle-stranded DNA endonuclease, cleaves single-stranded DNAduring nucleotide excision repair to excisedamaged DNA; subunit of Nucleotide ExcisionRepair Factor 3 (NEF3); homolog of human XPGprotein 0.004850.12939&radic S000003307PRP38YGR075CverifiedUnique component of the U4/U6.U5 tri-snRNP particle,dispensable for spliceosome assembly, butrequired for conformational changes which leadto catalytic activation of the spliceosome 0.004820.12939&radic S000005274RPD3YNL330CverifiedHistone deacetylase; regulates transcription and silencing 0.004810.12939&radic S000002473YDR066CUncharacterizedHypothetical protein 0.004820.12939 S000002965SMX2YFL017W-AverifiedCore Sm protein Sm G; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm G 0.004850.12939&radic S000003804POL32YJR043CverifiedThird subunit of DNA polymerase delta, involved in chromosomalDNA replication; required for error-prone DNAsynthesis in the presence of DNA damage andprocessivity; interacts with Hys2p, PCNA(Pol30p), and Pol1p 0.004810.12934&radic&radic S000004042IES3YLR052WverifiedSubunit of the INO80 chromatin remodeling complex 0.004740.12744&radic S000005475PAP2YOL115WverifiedCatalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), anuclear poly (A) polymerase complex involved inRNA quality control; catalyzes polyadenylationof unmodified tRNAs, and snoRNA and rRNAprecursors; disputed role as a DNA polymerase 0.004760.12744&radic S000003772YJR011CUncharacterizedHypothetical protein 0.004760.12744 S000002175CDC7YDL017WverifiedDDK (Dbf4-dependent kinase) catalytic subunit required forfiring origins and replication fork progressionin mitosis through phosphorylation of Mcm2-7pcomplexes and Cdc45p; kinase activitycorrelates with cyclical DBF4 expression 0.004760.12744&radic S000002773ESF1YDR365CverifiedNucleolar protein involved in pre-rRNA processing; depletioncauses severely decreased 18S rRNA levels 0.004770.12744&radic S000000703RDS1YCR106WverifiedZinc cluster protein involved in conferring resistance tocycloheximide 0.004740.12735 S000003189NIF3YGL221CverifiedProtein of unknown function, similar to Listeria monocytogenesmajor sigma factor (rpoD gene product); theauthentic, non-tagged protein is detected inhighly purified mitochondria in high-throughputstudies 0.004720.12665 S000002796RVS167YDR388WverifiedActin-associated protein, subunit of a complex(Rvs161p-Rvs167p) involved in regulation ofactin cytoskeleton, endocytosis, and viabilityfollowing starvation or osmotic stress; homologof mammalian amphiphysin 0.004710.12576&radic S000003306SMD1YGR074WverifiedCore Sm protein Sm D1; part of heteroheptameric complex (withSmb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D1 0.00470.12576&radic S000005945RMI1YPL024WverifiedInvolved in response to DNA damage; null mutants have increasedrates of recombination and delayed S phase;interacts physically and genetically with Sgs1p(RecQ family member) and Top3p (topoisomeraseIII) 0.004690.12576&radic S000004107CLF1YLR117CverifiedEssential splicesome assembly factor; contains multipletetratricopeptide repeat (TPR) protein-bindingmotifs and interacts specifically with manyspliceosome components, may serve as a scaffoldduring splicesome assembly 0.004680.12515&radic S000006088REV3YPL167CverifiedCatalytic subunit of DNA polymerase zeta, which is involved inDNA repair and translesion synthesis; requiredfor mutagenesis induced by DNA damage 0.004690.12515 S000000948LSM5YER146WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.004660.12474 S000004704YMR098CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR098C is not an essential gene 0.004660.12474 S000002551MKC7YDR144CverifiedGPI-anchored aspartyl protease (yapsin) involved in proteinprocessing; shares functions with Yap3p andKex2p 0.004660.12474 S000002633HTA1YDR225WverifiedOne of two nearly identical (see also HTA2) histone H2Asubtypes; core histone required for chromatinassembly and chromosome function; DNAdamage-dependent phosphorylation by Mec1pfacilitates DNA repair; acetylated by Nat4p 0.004610.1232 S000003899IML1YJR138WverifiedProtein of unknown function, green fluorescent protein(GFP)-fusion protein localizes to the vacuolarmembrane 0.004610.12299 S000002868TFB3YDR460WverifiedSubunit of TFIIH and nucleotide excision repair factor 3complexes, involved in transcriptioninitiation, required for nucleotide excisionrepair; ring finger protein similar tomammalian CAK and TFIIH subunit 0.00460.12251&radic S000002266KIN28YDL108WverifiedSerine/threonine protein kinase, subunit of the transcriptionfactor TFIIH; involved in transcriptioninitiation at RNA polymerase II promoters 0.004590.12251&radic S000005622RPS7AYOR096WverifiedProtein component of the small (40S) ribosomal subunit, nearlyidentical to Rps7Bp; interacts with Kti11p;deletion causes hypersensitivity to zymocin;has similarity to rat S7 and Xenopus S8ribosomal proteins 0.004580.12201 S000004313SFH1YLR321CverifiedSubunit of the RSC chromatin remodeling complex required forkinetochore function in chromosome segregation;essential gene required for cell cycleprogression; phosphorylated in the G1 phase ofthe cell cycle; Snf5p paralog 0.004580.12201&radic S000004265SMD2YLR275WverifiedCore Sm protein Sm D2; part of heteroheptameric complex (withSmb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D2 0.004570.12201&radic S000000944MAG1YER142Cverified3-methyl-adenine DNA glycosylase involved in protecting DNAagainst alkylating agents; initiates baseexcision repair by removing damaged bases tocreate abasic sites that are subsequentlyrepaired 0.004580.12201&radic S000005194RAD50YNL250WverifiedSubunit of MRX complex, with Mre11p and Xrs2p, involved inprocessing double-strand DNA breaks invegetative cells, initiation of meiotic DSBs,telomere maintenance, and nonhomologous endjoining 0.004560.12105&radic S000004596RSC9YML127WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; DNA-binding protein involved inthe synthesis of rRNA and in transcriptionalrepression and activation of genes regulated bythe Target of Rapamycin (TOR) pathway 0.004540.12063&radic S000004082SUL2YLR092WverifiedHigh affinity sulfate permease; sulfate uptake is mediated byspecific sulfate transporters Sul1p and Sul2p,which control the concentration of endogenousactivated sulfate intermediates 0.004540.12063 S000001764TRM2YKR056WverifiedtRNA methyltransferase, 5-methylates the uridine residue atposition 54 of tRNAs and may also have a rolein tRNA stabilization or maturation; previouslythought to be an endo-exonuclease 0.004530.12053 S000003651ASF1YJL115WverifiedNucleosome assembly factor, involved in chromatin assembly anddisassembly, anti-silencing protein that causesderepression of silent loci when overexpressed 0.004520.12004&radic S000006074RAD53YPL153CverifiedProtein kinase, required for cell-cycle arrest in response toDNA damage; activated by transautophosphorylation when interacting withhyperphosphorylated Rad9p; also interacts withARS1 and plays a role in initiation of DNAreplication 0.004480.11865&radic S000002686YDR278CDubiousHypothetical protein 0.004490.11865 S000002632HTB1YDR224CverifiedOne of two nearly identical (see HTB2) histone H2B subtypesrequired for chromatin assembly and chromosomefunction; Rad6p-Bre1p-Lge1p mediatedubiquitination regulates transcriptionalactivation, meiotic DSB formation and H3methylation 0.004490.11865&radic S000000808NUG1YER006WverifiedGTPase that associates with nuclear 60S pre-ribosomes, requiredfor export of 60S ribosomal subunits from thenucleus 0.004490.11865&radic S000004655YMR052C-ADubiousHypothetical protein 0.00450.11865 S000004697NPL6YMR091CverifiedComponent of the RSC chromatin remodeling complex; interactswith Rsc3p, Rsc30p, Ldb7p, and Htl1p to form amodule important for a broad range of RSCfunctions; involved in nuclear protein importand maintenance of proper telomere length 0.004510.11865&radic&radic S000002542YCF1YDR135CverifiedVacuolar glutathione S-conjugate transporter of the ATP-bindingcassette family, has a role in detoxifyingmetals such as cadmium, mercury, and arsenite;also transports unconjugated bilirubin; similarto human cystic fibrosis protein CFTR 0.004490.11865 S000002334AIR2YDL175CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p; may regulatemethylation of Npl3p, which modulates Npl3pfunction in mRNA processing and export; hassimilarity to Air1p 0.00450.11865&radic S000000483PAF1YBR279WverifiedRNA polymerase II-associated protein, defines a large complexthat is biochemically and functionally distinctfrom the Srb-Mediator form of Pol II holoenzymeand is required for full expression of a subsetof cell cycle-regulated genes 0.004470.11846&radic&radic S000001346SDS3YIL084CverifiedComponent of the Rpd3p/Sin3p deacetylase complex required forits structural integrity and catalyticactivity, involved in transcriptional silencingand required for sporulation; cells defectivein SDS3 display pleiotropic phenotypes 0.004450.11776&radic S000000356SPP381YBR152WverifiedmRNA splicing factor, component of U4/U6.U5 tri-snRNP;interacts genetically and physically withPrp38p 0.004450.11776&radic S000005221MET2YNL277WverifiedL-homoserine-O-acetyltransferase, catalyzes the conversion ofhomoserine to O-acetyl homoserine which is thefirst step of the methionine biosyntheticpathway 0.004450.11776&radic S000005937SWI1YPL016WverifiedSubunit of the SWI/SNF chromatin remodeling complex, whichregulates transcription by remodelingchromosomes; required for transcription of manygenes, including ADH1, ADH2, GAL1, HO, INO1 andSUC2 0.004440.11754&radic S000006050TAF14YPL129WverifiedSubunit (30 kDa) of TFIID, TFIIF, and SWI/SNF complexes,involved in RNA polymerase II transcriptioninitiation and in chromatin modification,contains a YEATS domain 0.004440.11754&radic&radic S000002372NOP6YDL213CuncharacterizedProtein with similarity to hydrophilins, which are involved inthe adaptive response to hyperosmoticconditions; computational analysis oflarge-scale protein-protein interaction datasuggests a possible role in rRNA processing 0.004440.11721 S000005895RAD17YOR368WverifiedCheckpoint protein, involved in the activation of the DNAdamage and meiotic pachytene checkpoints; withMec3p and Ddc1p, forms a clamp that is loadedonto partial duplex DNA; homolog of human andS. pombe Rad1 and U. maydis Rec1 proteins 0.004410.11665 S000003141KEM1YGL173CverifiedEvolutionarily-conserved 5'-3' exonuclease component ofcytoplasmic processing (P) bodies involved inmRNA decay; plays a role inmicrotubule-mediated processes, filamentousgrowth, ribosomal RNA maturation, and telomeremaintenance 0.004410.11652 S000003948PAU17YLL025WuncharacterizedPutative protein of unknown function; YLL025W is not anessential gene 0.004410.11652 S000003695HSP150YJL159WverifiedO-mannosylated heat shock protein that is secreted andcovalently attached to the cell wall viabeta-1,3-glucan and disulfide bridges; requiredfor cell wall stability; induced by heat shock,oxidative stress, and nitrogen limitation 0.004390.116 S000002918SMT3YDR510WverifiedUbiquitin-like protein of the SUMO family, conjugated to lysineresidues of target proteins; regulateschromatid cohesion, chromosome segregation,APC-mediated proteolysis, DNA replication andseptin ring dynamics 0.004370.11524&radic S000004814RAD14YMR201CverifiedProtein that recognizes and binds damaged DNA during nucleotideexcision repair; subunit of Nucleotide ExcisionRepair Factor 1 (NEF1); contains zinc fingermotif; homolog of human XPA protein 0.004370.11524&radic S000003288RSC1YGR056WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; containstwo essential bromodomains, a bromo-adjacenthomology (BAH) domain, and an AT hook 0.004340.11417 S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling 0.004360.11417&radic&radic S000001240RIX1YHR197WverifiedEssential protein involved in the processing of the ITS2 regionof the rRNA locus; required for the maturationand nuclear export of the 60S ribosomal subunit 0.004340.11417&radic S000004837MRE11YMR224CverifiedSubunit of a complex with Rad50p and Xrs2p (RMX complex) thatfunctions in repair of DNA double-strand breaksand in telomere stability, exhibits nucleaseactivity that appears to be required for RMXfunction; widely conserved 0.004340.11417&radic S000002904PUF6YDR496CverifiedPumilio-homology domain protein that binds ASH1 mRNA at PUFconsensus sequences in the 3' UTR and repressesits translation, resulting in proper asymmetriclocalization of ASH1 mRNA 0.004360.11417&radic S000001412MCM10YIL150CverifiedEssential, chromatin-associated protein involved in theinitiation of DNA replication; required for theassociation of the MCM2-7 complex withreplication origins 0.004330.11417&radic S000000214HHT1YBR010WverifiedOne of two identical histone H3 proteins (see also HHT2); corehistone required for chromatin assembly,involved in heterochromatin-mediated telomericand HM silencing; regulated by acetylation,methylation, and mitotic phosphorylation 0.004330.11391&radic S000000292POL30YBR088CverifiedProliferating cell nuclear antigen (PCNA), functions as thesliding clamp for DNA polymerase delta; mayfunction as a docking site for other proteinsrequired for mitotic and meiotic chromosomalDNA replication and for DNA repair 0.004330.11391&radic S000004752YMR144WUncharacterizedPutative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene 0.004310.11313&radic S000005979PDR12YPL058CverifiedPlasma membrane weak-acid-inducible ATP-binding cassette (ABC)transporter, required for weak organic acidresistance, strongly induced by sorbate andbenzoate, regulated by War1p, mutants exhibitsorbate hypersensitivity 0.004310.11313 S000005243TRF5YNL299WverifiedPoly (A) polymerase involved in nuclear RNA quality controlbased on: homology with Trf4p, geneticinteractions with TRF4 mutants, physicalinteraction with Mtr4p (TRAMP subunit), and bydirect assay; disputed role as a sigma DNApolymerase 0.004310.11313 S000000099HTA2YBL003CverifiedOne of two nearly identical (see also HTA1) histone H2Asubtypes; core histone required for chromatinassembly and chromosome function; DNAdamage-dependent phosphorylation by Mec1pfacilitates DNA repair; acetylated by Nat4p 0.00430.1131&radic S000000259PRP6YBR055CverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.004280.11219&radic S000000950SPT15YER148WverifiedTATA-binding protein, general transcription factor thatinteracts with other factors to form thepreinitiation complex at promoters, essentialfor viability 0.004280.11219&radic S000000223GAL10YBR019CverifiedUDP-glucose-4-epimerase, catalyzes the interconversion ofUDP-galactose and UDP-D-glucose in galactosemetabolism; also catalyzes the conversion ofalpha-D-glucose or alpha-D-galactose to theirbeta-anomers 0.004280.11219 S000001341AIR1YIL079CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p to regulate methylationof Npl3p, which modulates Npl3p function inmRNA processing and export; has similarity toAir2p 0.004270.11127&radic S000000217YBR013CUncharacterizedHypothetical protein 0.004260.11127 S000005685SME1YOR159CverifiedCore Sm protein Sm E; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm E 0.004270.11127 S000000213HHF1YBR009CverifiedOne of two identical histone H4 proteins (see also HHF2); corehistone required for chromatin assembly andchromosome function; contributes to telomericsilencing; N-terminal domain involved inmaintaining genomic integrity 0.004230.11066&radic S000003992NOC3YLR002CverifiedProtein that forms a nuclear complex with Noc2p that binds to66S ribosomal precursors to mediate theirintranuclear transport; also binds to chromatinto promote the association of DNA replicationfactors and replication initiation 0.004220.11016&radic S000000692HMRA2YCR096CverifiedSilenced copy of a2 at HMR; similarity to Alpha2p; requiredalong with a1p for inhibiting expression of theHO endonuclease in a/alpha HO/HO diploid cellswith an active mating-type interconversionsystem 0.004220.11016 S000006043TFB2YPL122CverifiedSubunit of TFIIH and nucleotide excision repair factor 3complexes, involved in transcriptioninitiation, required for nucleotide excisionrepair, similar to 52 kDa subunit of humanTFIIH 0.00420.10971&radic S000001697YRA2YKL214CverifiedMember of the REF (RNA and export factor binding proteins)family; when overexpressed, can substitute forthe function of Yra1p in export of poly(A)+mRNA from the nucleus 0.004180.10908&radic S000005446ADH1YOL086CverifiedAlcohol dehydrogenase, fermentative isozyme active as homo- orheterotetramers; required for the reduction ofacetaldehyde to ethanol, the last step in theglycolytic pathway 0.004180.10908&radic S000001108SSF1YHR066WverifiedConstituent of 66S pre-ribosomal particles, required forribosomal large subunit maturation;functionally redundant with Ssf2p; member ofthe Brix family 0.004170.1085&radic S000003626DPB11YJL090CverifiedEssential BRCT repeat protein, required on the prereplicativecomplex at replication origins for loading DNApolymerases to initiate DNA synthesis, alsorequired for S/M checkpoint control 0.004160.10838&radic S000000307SIF2YBR103WverifiedWD40 repeat-containing subunit of the Set3C histone deacetylasecomplex, which represses early/middlesporulation genes; antagonizes telomericsilencing; binds specifically to the Sir4pN-terminus 0.004130.10771&radic S000001141TRA1YHR099WverifiedSubunit of SAGA and NuA4 histone acetyltransferase complexes;interacts with acidic activators (e.g., Gal4p)which leads to transcription activation;similar to human TRRAP, which is a cofactor forc-Myc mediated oncogenic transformation 0.004140.10771 S000004300IMH1YLR309CverifiedProtein involved in vesicular transport, mediates transportbetween an endosomal compartment and the Golgi,contains a Golgi-localization (GRIP) domainthat interacts with activated Arl1p-GTP tolocalize Imh1p to the Golgi 0.004130.10767 S000004693YMR087WVerifiedPutative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain 0.004130.10767 S000005499CDC33YOL139CverifiedCytoplasmic mRNA cap binding protein; the eIF4E-cap complex isresponsible for mediating cap-dependent mRNAtranslation via interactions with thetranslation initiation factor eIF4G (Tif4631por Tif4632p) 0.004090.10608 S000002241RPS16BYDL083CverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps16Ap and has similarity to E.coli S9 and rat S16 ribosomal proteins 0.004080.10569 S000004712YKU80YMR106CverifiedSubunit of the telomeric Ku complex (Yku70p-Yku80p), involvedin telomere length maintenance, structure andtelomere position effect; relocates to sites ofdouble-strand cleavage to promote nonhomologousend joining during DSB repair 0.004060.10507&radic S000005732NOC2YOR206WverifiedProtein that forms a nucleolar complex with Mak21p that bindsto 90S and 66S pre-ribosomes, as well as anuclear complex with Noc3p that binds to 66Spre-ribosomes; both complexes mediateintranuclear transport of ribosomal precursors 0.004070.10507&radic S000001484MET14YKL001CverifiedAdenylylsulfate kinase, required for sulfate assimilation andinvolved in methionine metabolism 0.004060.10507 S000004886ZDS1YMR273CverifiedProtein that interacts with silencing proteins at the telomere,involved in transcriptional silencing; has arole in localization of Bcy1p, a regulatorysubunit of protein kinase A; implicated in mRNAnuclear export 0.004060.10507 S000006439HTL1YCR020W-BverifiedSubunit of the RSC chromatin remodeling complex, a multisubunitcomplex that functions in transcriptionalregulation, chromosome stability andestablishing sister chromatid cohesion;involved in telomere maintenance 0.004050.10489&radic&radic S000005119NOP13YNL175CverifiedProtein of unknown function, localizes to the nucleolus andnucleoplasm; contains an RNA recognition motif(RRM) and has similarity to Nop12p, which isrequired for processing of pre-18S rRNA 0.004050.10489&radic S000003322UTP22YGR090WuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.004040.10459&radic S000000201PKC1YBL105CverifiedProtein serine/threonine kinase essential for cell wallremodeling during growth; localized to sites ofpolarized growth and the mother-daughter budneck; homolog of the alpha, beta, and gammaisoforms of mammalian protein kinase C (PKC) 0.004050.10459 S000002618YDR210WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery 0.004050.10459 S000005252KRI1YNL308CverifiedEssential nucleolar protein required for 40S ribosomebiogenesis; physically and functionallyinteracts with Krr1p 0.004030.10402 S000005798YTM1YOR272WverifiedConstituent of 66S pre-ribosomal particles, required formaturation of the large ribosomal subunit 0.004030.10402&radic S000001870EPL1YFL024CverifiedComponent of NuA4, which is an essential histone H4/H2Aacetyltransferase complex; homologous toDrosophila Enhancer of Polycomb 0.004020.10402&radic S000001377NUP159YIL115CverifiedSubunit of the nuclear pore complex that is found exclusivelyon the cytoplasmic side, forms a subcomplexwith Nup82p and Nsp1p, required for mRNA export 0.004010.10321 S000006286DIB1YPR082Cverified17-kDa component of the U4/U6aU5 tri-snRNP, plays an essentialrole in pre-mRNA splicing, orthologue of hDIM1,the human U5-specific 15-kDa protein 0.004010.10321 S000005437BRX1YOL077CverifiedNucleolar protein, constituent of 66S pre-ribosomal particles;depletion leads to defects in rRNA processingand a block in the assembly of large ribosomalsubunits; possesses a sigma(70)-likeRNA-binding motif 0.004020.10321&radic S000000225FUR4YBR021WverifiedUracil permease, localized to the plasma membrane; expressionis tightly regulated by uracil levels andenvironmental cues 0.003990.10219 S000003055MMS2YGL087CverifiedProtein involved in error-free postreplication DNA repair;forms a heteromeric complex with Ubc13p thathas a ubiquitin-conjugating activity;cooperates with chromatin-associated RINGfinger proteins, Rad18p and Rad5p 0.003980.10219&radic S000005964NOP4YPL043WverifiedNucleolar protein, essential for processing and maturation of27S pre-rRNA and large ribosomal subunitbiogenesis; constituent of 66S pre-ribosomalparticles; contains four RNA recognition motifs(RRMs) 0.003980.10219&radic S000001805PCK1YKR097WverifiedPhosphoenolpyruvate carboxykinase, key enzyme ingluconeogenesis, catalyzes early reaction incarbohydrate biosynthesis, glucose repressestranscription and accelerates mRNA degradation,regulated by Mcm1p and Cat8p, located in thecytosol 0.003990.10219 S000005401NOP12YOL041CverifiedNucleolar protein, required for pre-25S rRNA processing;contains an RNA recognition motif (RRM) and hassimilarity to Nop13p, Nsr1p, and putativeorthologs in Drosophila and S. pombe 0.003950.10036 S000005013RPL16BYNL069CverifiedN-terminally acetylated protein component of the large (60S)ribosomal subunit, binds to 5.8 S rRNA; hassimilarity to Rpl16Ap, E. coli L13 and rat L13aribosomal proteins; transcriptionally regulatedby Rap1p 0.003930.10036 S000001056SPO13YHR014WverifiedMeiosis-specific protein, involved in maintaining sisterchromatid cohesion during meiosis I as well aspromoting proper attachment of kinetochores tothe spindle during meiosis I and meiosis II 0.003930.10036 S000006393SKI3YPR189WverifiedProtein involved in exosome mediated 3' to 5' mRNA degradationand translation inhibition of non-poly(A)mRNAs; forms complex with Ski2p and Ski8p;required for repressing propagation of dsRNAviruses 0.003940.10036 S000006284TEF1YPR080WverifiedTranslational elongation factor EF-1 alpha; also encoded byTEF2; functions in the binding reaction ofaminoacyl-tRNA (AA-tRNA) to ribosomes 0.003930.10036 S000004585NAB6YML117WuncharacterizedPutative RNA-binding protein, based on computational analysisof large-scale protein-protein interaction data 0.003930.10036 S000004722ASC1YMR116CverifiedWD repeat protein (G-beta like protein) involved in translationregulation; required for repression of Gcn4pactivity in the absence of amino-acidstarvation; core component of the ribosome;ortholog of mammalian RACK1 0.003920.10029&radic S000002772CDC40YDR364CverifiedPre-mRNA splicing factor, important for catalytic step II ofpre-mRNA splicing and plays a role in cellcycle progression; required for DNA synthesisduring mitosis and meiosis; has WD repeats 0.003910.09928&radic&radic S000001132YNG2YHR090CverifiedSubunit of the NuA4 histone acetyltransferase complex thatacetylates histone H4 and H2A; has similarityto the human tumor suppressor ING1 0.003870.09869&radic S000001234CTF8YHR191CverifiedSubunit of a complex with Ctf18p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion 0.003870.09836 S000004410CDC73YLR418CverifiedConstituent of Paf1 complex with RNA polymerase II, Paf1p,Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinctfrom Srb-containing Pol II complexes; requiredfor expression of certain genes, modificationof some histones, and telomere maintenance 0.003870.09836&radic&radic S000004751RPS16AYMR143WverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps16Bp and has similarity to E.coli S9 and rat S16 ribosomal proteins 0.003870.09836 S000000230ETR1YBR026Cverified2-enoyl thioester reductase, member of the medium chaindehydrogenase/reductase family; localized to inmitochondria, where it has a probable role infatty acid synthesis 0.003860.09707 S000000735GCN4YEL009CverifiedTranscriptional activator of amino acid biosynthetic genes inresponse to amino acid starvation; expressionis tightly regulated at both thetranscriptional and translational levels 0.003840.09707&radic S000005602SKI7YOR076CverifiedAntiviral adaptor protein that mediates interactions via itsN-terminus between the exosome and Ski complex(Ski2p, Ski3p, Ski8p) which operate in the3'-to-5' mRNA-decay pathway; cytoplasmicprotein required for degrading nonstop mRNAs 0.003860.09707 S000004523SML1YML058WverifiedRibonucleotide reductase inhibitor involved in regulating dNTPproduction; regulated by Mec1p and Rad53pduring DNA damage and S phase 0.003850.09707&radic S000005873REV1YOR346WverifiedDeoxycytidyl transferase, forms a complex with the subunits ofDNA polymerase zeta, Rev3p and Rev7p; involvedin repair of abasic sites in damaged DNA 0.003830.09671&radic S000001210THP2YHR167WverifiedSubunit of the THO complex, which connects transcriptionelongation and mitotic recombination, and ofthe TREX complex, which is recruited toactivated genes and couples transcription tomRNA export; involved in telomere maintenance 0.003820.09624&radic S000005197TEX1YNL253WverifiedProtein involved in mRNA export, component of the transcriptionexport (TREX) complex 0.00380.09599 S000001596RAD27YKL113Cverified5' to 3' exonuclease, 5' flap endonuclease, required forOkazaki fragment processing and maturation aswell as for long-patch base-excision repair;member of the S. pombe RAD2/FEN1 family 0.003810.09599&radic S000001806UBP11YKR098CverifiedUbiquitin-specific protease that cleaves ubiquitin fromubiquitinated proteins 0.00380.09576 S000002893VPS72YDR485CverifiedHtz1p-binding component of the SWR1 complex, which exchangeshistone variant H2AZ (Htz1p) forchromatin-bound histone H2A; required forvacuolar protein sorting 0.003780.09479&radic S000002467MAK21YDR060WverifiedConstituent of 66S pre-ribosomal particles, required for large(60S) ribosomal subunit biogenesis; involved innuclear export of pre-ribosomes; required formaintenance of dsRNA virus; homolog of humanCAATT-binding protein 0.003780.09479 S000004140STM1YLR150WverifiedProtein that binds G4 quadruplex and purine motif triplexnucleic acid; acts with Cdc13p to maintaintelomere structure; interacts with ribosomesand subtelomeric Y' DNA; multicopy suppressorof tom1 and pop2 mutations 0.003740.09384 S000004651CSM3YMR048WverifiedProtein required for accurate chromosome segregation duringmeiosis 0.003750.09384&radic S000000804NOP16YER002WverifiedConstituent of 66S pre-ribosomal particles, involved in 60Sribosomal subunit biogenesis 0.003760.09384&radic S000000653PWP2YCR057CverifiedConserved 90S pre-ribosomal component essential for properendonucleolytic cleavage of the 35 S rRNAprecursor at A0, A1, and A2 sites; containseight WD-repeats; PWP2 deletion leads todefects in cell cycle and bud morphogenesis 0.003750.09384 S000004852RNT1YMR239CverifiedRNAase III; cleaves a stem-loop structure at the 3' end of U2snRNA to ensure formation of the correct U2 3'end 0.003750.09384&radic S000001083SRB2YHR041CverifiedGeneral transcription factor, subunit of the RNA polymerase IImediator complex; associates with corepolymerase subunits to form the RNA polymeraseII holoenzyme; involved in telomere maintenance 0.003730.09314&radic&radic S000006119RPL7BYPL198WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl7Ap and has similarity to E.coli L30 and rat L7 ribosomal proteins;contains a conserved C-terminal Nucleic acidBinding Domain (NDB2) 0.003730.09314 S000004279MEC3YLR288CverifiedDNA damage and meiotic pachytene checkpoint protein; subunit ofa heterotrimeric complex (Rad17p-Mec3p-Ddc1p)that forms a sliding clamp, loaded onto partialduplex DNA by a clamp loader complex; homologof human and S. pombe Hus1 0.003720.09265 S000001789RPF2YKR081CverifiedEssential protein involved in the processing of pre-rRNA andthe assembly of the 60S ribosomal subunit;interacts with ribosomal protein L11; localizespredominantly to the nucleolus; constituent of66S pre-ribosomal particles 0.003720.09265&radic S000004165CBF5YLR175WverifiedPseudouridine synthase catalytic subunit of box H/ACA smallnucleolar ribonucleoprotein particles(snoRNPs), acts on both large and small rRNAsand on snRNA U2 0.003720.09265 S000001312PCL7YIL050WverifiedPho85p cyclin of the Pho80p subfamily, forms a functionalkinase complex with Pho85p which phosphorylatesMmr1p and is regulated by Pho81p; involved inglycogen metabolism, expression is cell-cycleregulated 0.003710.09265 S000006132NIP7YPL211WverifiedNucleolar protein required for 60S ribosome subunit biogenesis,constituent of 66S pre-ribosomal particles;physically interacts with Nop8p and the exosomesubunit Rrp43p 0.003710.09265&radic S000000780RPL12AYEL054CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl12Bp; rpl12a rpl12b doublemutant exhibits slow growth and slowtranslation; has similarity to E. coli L11 andrat L12 ribosomal proteins 0.00370.09218 S000004842RRP5YMR229CverifiedProtein required for the synthesis of both 18S and 5.8S rRNA;C-terminal region is crucial for the formationof 18S rRNA and N-terminal region is requiredfor the 5.8S rRNA; component of small ribosomalsubunit (SSU) processosome 0.00370.09218 S000002566SAC3YDR159WverifiedNuclear pore-associated protein, forms a complex with Thp1pthat is involved in transcription and in mRNAexport from the nucleus 0.003710.09218 S000001183RPL42BYHR141CverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl42Ap and has similarity to ratL44; required for propagation of the killertoxin-encoding M1 double-stranded RNA satelliteof the L-A double-stranded RNA virus 0.003690.09176 S000005226POP3YNL282WverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends 0.003690.09176&radic S000000009SWC3YAL011WverifiedProtein of unknown function, component of the SWR1 complex,which exchanges histone variant H2AZ (Htz1p)for chromatin-bound histone H2A; required forformation of nuclear-associated array of smoothendoplasmic reticulum known as karmellae 0.00370.09176&radic S000006220TIF6YPR016CverifiedConstituent of 66S pre-ribosomal particles, has similarity tohuman translation initiation factor 6 (eIF6);may be involved in the biogenesis and orstability of 60S ribosomal subunits 0.00370.09176&radic S000002688RRP45YDR280WverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex 0.003690.09176&radic S000002517FOB1YDR110WverifiedNucleolar protein required for DNA replication fork blockingand recombinational hotspot activities; bindsto the replication fork barrier site in therDNA region; related to retroviral integrases 0.003680.09105 S000001897LOC1YFR001WverifiedNuclear protein involved in asymmetric localization of ASH1mRNA; binds double-stranded RNA in vitro;constituent of 66S pre-ribosomal particles 0.003670.09105&radic S000000379SWD3YBR175WverifiedEssential subunit of the COMPASS (Set1C) complex, whichmethylates histone H3 on lysine 4 and isrequired in transcriptional silencing neartelomeres; WD40 beta propeller superfamilymember and ortholog of mammalian WDR5 0.003660.09079&radic S000005366TOP1YOL006CverifiedTopoisomerase I, nuclear enzyme that relieves torsional strainin DNA by cleaving and re-sealing thephosphodiester backbone; relaxes bothpositively and negatively supercoiled DNA;functions in replication, transcription, andrecombination 0.003630.0896&radic S000001052RPL27AYHR010WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl27Bp and has similarity to ratL27 ribosomal protein 0.003630.0896 S000001297CKA1YIL035CverifiedAlpha catalytic subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA2, CKB1 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.003640.0896&radic S000004470SPT5YML010WverifiedProtein that forms a complex with Spt4p and mediates bothactivation and inhibition of transcriptionelongation; Spt4p-Spt5p complex also plays arole in pre-mRNA processing 0.003630.0896&radic S000004040YLR050CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene 0.003640.0896 S000000689CDC39YCR093WverifiedComponent of the CCR4-NOT complex, which has multiple roles inregulating mRNA levels including regulation oftranscription and destabilizing mRNAs bydeadenylation; basal transcription factor 0.003650.0896 S000004441FPR4YLR449WverifiedPeptidyl-prolyl cis-trans isomerase (PPIase) (prolineisomerase) localized to the nucleus; catalyzesisomerization of proline residues in histonesH3 and H4, which affects lysine methylation ofthose histones 0.003620.08925&radic S000000184TEL1YBL088CverifiedProtein kinase primarily involved in telomere lengthregulation; contributes to cell cyclecheckpoint control in response to DNA damage;functionally redundant with Mec1p; homolog ofhuman ataxia telangiectasia (ATM) gene 0.00360.08866 S000001953YFR057WUncharacterizedHypothetical protein 0.003610.08866 S000004421CRN1YLR429WverifiedCoronin, cortical actin cytoskeletal component that associateswith the Arp2p/Arp3p complex to regulate itsactivity 0.00360.08866 S000004527MFT1YML062CverifiedSubunit of the THO complex, which is a nuclear complexcomprised of Hpr1p, Mft1p, Rlr1p, and Thp2p,that is involved in transcription elongationand mitotic recombination; involved in telomeremaintenance 0.003590.08791&radic S000006161HSP82YPL240CverifiedCytoplasmic chaperone (Hsp90 family) required for pheromonesignaling and negative regulation of Hsf1p;docks with the mitochondrial import receptorTom70p for preprotein delivery; interacts withco-chaperones Cns1p, Cpr6p, Cpr7p, and Sti1p 0.00360.08791 S000002172NOP1YDL014WverifiedNucleolar protein, component of the small subunit processomecomplex, which is required for processing ofpre-18S rRNA; has similarity to mammalianfibrillarin 0.003590.08791 S000002476DOA4YDR069CverifiedUbiquitin hydrolase, required for recycling ubiquitin fromproteasome-bound ubiquitinated intermediates,acts at the late endosome/prevacuolarcompartment to recover ubiquitin fromubiquitinated membrane proteins en route to thevacuole 0.003590.08791&radic S000002858RPS18AYDR450WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps18Bp and has similarity to E.coli S13 and rat S18 ribosomal proteins 0.003590.08791 S000002299RPO21YDL140CverifiedRNA polymerase II largest subunit B220, part of central core;phosphorylation of C-terminal heptapeptiderepeat domain regulates association withtranscription and splicing factors; similar tobacterial beta-prime 0.003570.0877&radic S000004400YLR408CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene 0.003570.0877 S000005534SLG1YOR008CverifiedSensor-transducer of the stress-activated PKC1-MPK1 kinasepathway involved in maintenance of cell wallintegrity; involved in organization of theactin cytoskeleton; secretory pathway Wsc1p isrequired for the arrest of secretion response 0.003570.08749 S000001597APN1YKL114CverifiedMajor apurinic/apyrimidinic endonuclease, 3'-repair diesteraseinvolved in repair of DNA damage by oxidationand alkylating agents; also functions as a3'-5' exonuclease to repair7,8-dihydro-8-oxodeoxyguanosine 0.003560.0872&radic S000000801YEL075CUncharacterizedHypothetical protein 0.003560.0872 S000002495SLU7YDR088CverifiedRNA splicing factor, required for ATP-independent portion of2nd catalytic step of spliceosomal RNAsplicing; interacts with Prp18p; contains zincknuckle domain 0.003550.08664&radic S000000770IES6YEL044WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.003550.08664&radic&radic S000000662RAD18YCR066WverifiedProtein involved in postreplication repair; bindssingle-stranded DNA and has single-stranded DNAdependent ATPase activity; forms heterodimerwith Rad6p; contains RING-finger motif 0.003550.08664 S000001394CSM2YIL132CverifiedProtein required for accurate chromosome segregation duringmeiosis 0.003540.08644&radic S000003181SKI8YGL213CverifiedProtein involved in exosome mediated 3' to 5' mRNA degradationand translation inhibition of non-poly(A) mRNAsas well as double-strand break formation duringmeiotic recombination; required for repressingpropagation of dsRNA viruses 0.003530.08608 S000003610SMC3YJL074CverifiedSubunit of the multiprotein cohesin complex required for sisterchromatid cohesion in mitotic cells; alsorequired, with Rec8p, for cohesion andrecombination during meiosis; phylogeneticallyconserved SMC chromosomal ATPase family member 0.003530.08605&radic S000005582NOB1YOR056CverifiedEssential nuclear protein involved in proteasome maturation andsynthesis of 40S ribosomal subunits; requiredfor cleavage of the 20S pre-rRNA to generatethe mature 18S rRNA 0.003510.08537 S000006014NOG1YPL093WverifiedPutative GTPase that associates with free 60S ribosomalsubunits in the nucleolus and is required for60S ribosomal subunit biogenesis; constituentof 66S pre-ribosomal particles; member of theODN family of nucleolar G-proteins 0.003510.08537&radic S000005080EAF7YNL136WverifiedSubunit of the NuA4 histone acetyltransferase complex, whichacetylates the N-terminal tails of histones H4and H2A 0.003510.08537&radic S000005715IES4YOR189WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.003510.08537&radic S000006339CTF4YPR135WverifiedChromatin-associated protein, required for sister chromatidcohesion; interacts with DNA polymerase alpha(Pol1p) and may link DNA synthesis to sisterchromatid cohesion 0.003510.08537&radic S000006438RPL36BYPL249C-AverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl36Ap and has similarity to ratL36 ribosomal protein; binds to 5.8 S rRNA 0.00350.08494 S000002200SIR2YDL042CverifiedConserved NAD+ dependent histone deacetylase of the Sirtuinfamily involved in regulation of lifespan;plays roles in silencing at HML, HMR,telomeres, and the rDNA locus; negativelyregulates initiation of DNA replication 0.00350.08494 S000002581HMO1YDR174WverifiedChromatin associated high mobility group (HMG) family memberinvolved in genome maintenance; rDNA-bindingcomponent of the Pol I transcription system;associates with a 5'-3' DNA helicase and Fpr1p,a prolyl isomerase 0.003490.08441 S000003930YLL007CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene 0.003490.08441 S000000885GET2YER083CverifiedSubunit of the GET complex; required for meiotic nucleardivision and for the retrieval of HDEL proteinsfrom the Golgi to the ER in an ERD2 dependentfashion; may be involved in cell wall function 0.003480.08441&radic S000004560RAD10YML095CverifiedSingle-stranded DNA endonuclease (with Rad1p), cleavessingle-stranded DNA during nucleotide excisionrepair and double-strand break repair; subunitof Nucleotide Excision Repair Factor 1 (NEF1);homolog of human ERCC1 protein 0.003440.08279&radic S000005054NOP15YNL110CverifiedConstituent of 66S pre-ribosomal particles, involved in 60Sribosomal subunit biogenesis; localizes to bothnucleolus and cytoplasm 0.003460.08279&radic S000003188YGL220WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus 0.003450.08279&radic S000003234SWC4YGR002CverifiedProtein of unknown function, component of the Swr1p complexthat incorporates Htz1p into chromatin;component of the NuA4 histone acetyltransferasecomplex 0.003470.08279&radic S000002366GLE1YDL207WverifiedCytoplasmic nucleoporin required for polyadenylated RNA exportbut not for protein import; component of Nup82pnuclear pore subcomplex; contains a nuclearexport signal 0.003440.08279 S000000818BIM1YER016WverifiedMicrotubule-binding protein that together with Kar9p makes upthe cortical microtubule capture site anddelays the exit from mitosis when the spindleis oriented abnormally 0.003440.08279 S000000961BUR6YER159CverifiedProtein that forms a heterodimeric histone-fold NC2 generaltranscription regulator complex with Ydr1p thatbinds to TBP and represses RNA pol IItranscription during assembly of thepreinitiation complex, homologous to humanNC2alpha 0.003450.08279&radic S000000912KAP123YER110CverifiedKaryopherin beta, mediates nuclear import of ribosomal proteinsprior to assembly into ribosomes and import ofhistones H3 and H4; localizes to the nuclearpore, nucleus, and cytoplasm; exhibits geneticinteractions with RAI1 0.003440.08279&radic S000005005NOP2YNL061WverifiedProbable RNA m(5)C methyltransferase, essential for processingand maturation of 27S pre-rRNA and largeribosomal subunit biogenesis; localized to thenucleolus; constituent of 66S pre-ribosomalparticles 0.003460.08279&radic S000002998RPL30YGL030WverifiedProtein component of the large (60S) ribosomal subunit, hassimilarity to rat L30 ribosomal protein;involved in pre-rRNA processing in thenucleolus; autoregulates splicing of itstranscript 0.003430.08256 S000001849SEC53YFL045CverifiedPhosphomannomutase, involved in synthesis of GDP-mannose anddolichol-phosphate-mannose; required forfolding and glycosylation of secretory proteinsin the ER lumen 0.003430.08256&radic S000002459DBF4YDR052CverifiedRegulatory subunit of Cdc7p-Dbf4p kinase complex, required forCdc7p kinase activity and initiation of DNAreplication; phosphorylates the Mcm2-7 familyof proteins; cell cycle regulated 0.003420.0822&radic S000000694HMRA1YCR097WverifiedSilenced copy of a1 at HMR; homeobox corepressor that interactswith Alpha2p to repress haploid-specific genetranscription in diploid cells 0.003430.0822 S000003391NSR1YGR159CverifiedNucleolar protein that binds nuclear localization sequences,required for pre-rRNA processing and ribosomebiogenesis 0.003430.0822 S000004505VPS71YML041Cverifiednucleosome-binding component of the SWR1 complex, whichexchanges histone variant H2AZ (Htz1p) forchromatin-bound histone H2A; required forvacuolar protein sorting 0.003420.0822&radic S000000224GAL1YBR020WverifiedGalactokinase, phosphorylates alpha-D-galactose toalpha-D-galactose-1-phosphate in the first stepof galactose catabolism; expression regulatedby Gal4p 0.003410.08177 S000004036YLR046CUncharacterizedPutative membrane protein, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance 0.003420.08177 S000002794MUS81YDR386WverifiedHelix-hairpin-helix protein, involved in DNA repair andreplication fork stability; functions as anendonuclease in complex with Mms4p; interactswith Rad54p 0.003410.08177&radic S000003149GTS1YGL181WverifiedProtein containing a zinc-finger in the N-terminus and a longGln-rich region in the C-terminus; regulatesultradian rhythm, cell size, cell cycle,lifespan, sporulation, heat tolerance, andmultidrug transport 0.003410.08177 S000002272YDL114WUncharacterizedPutative protein of unknown function with similarity to acyl-carrier-protein reductases; YDL114W is not an essential gene 0.003410.08177 S000000521DCC1YCL016CverifiedSubunit of a complex with Ctf8p and Ctf18p that shares somecomponents with Replication Factor C, requiredfor sister chromatid cohesion and telomerelength maintenance 0.003420.08177&radic S000007260COX1Q0045verifiedSubunit I of cytochrome c oxidase, which is the terminal memberof the mitochondrial inner membrane electrontransport chain; one of threemitochondrially-encoded subunits 0.003390.08136 S000000235RPL4AYBR031WverifiedN-terminally acetylated protein component of the large (60S)ribosomal subunit, nearly identical to Rpl4Bpand has similarity to E. coli L4 and rat L4ribosomal proteins 0.003380.08073 S000003807TAH11YJR046WverifiedDNA replication licensing factor, required for pre-replicationcomplex assembly 0.003380.08073&radic S000001197RTT107YHR154WverifiedProtein implicated in Mms22-dependent DNA repair during Sphase, DNA damage induces phosphorylation byMec1p at one or more SQ/TQ motifs; interactswith Mms22p and Slx4p; has four BRCT domains;has a role in regulation of Ty1 transposition 0.003380.08073&radic&radic S000004652ERB1YMR049CverifiedProtein required for maturation of the 25S and 5.8S ribosomalRNAs; constituent of 66S pre-ribosomalparticles; homologous to mammalian Bop1 0.003380.08073&radic S000001094CIC1YHR052WverifiedEssential protein that interacts with proteasome components andhas a potential role in proteasome substratespecificity; also copurifies with 66Spre-ribosomal particles 0.003380.08073&radic S000000168RPS8AYBL072CverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps8Bp and has similarity to ratS8 ribosomal protein 0.003370.08073 S000000435SWC5YBR231CuncharacterizedProtein of unknown function, component of the SWR1 complex,which exchanges histone variant H2AZ (Htz1p)for chromatin-bound histone H2A 0.003380.08073&radic S000003238PRP18YGR006WverifiedSplicing factor involved in the positioning of the 3' splicesite during the second catalytic step ofsplicing, recruited to the spliceosome by Slu7p 0.003370.08071 S000000015PSK1YAL017WverifiedOne of two (see also PSK2) PAS domain containing S/T proteinkinases; coordinately regulates proteinsynthesis and carbohydrate metabolism andstorage in response to a unknown metabolitethat reflects nutritional status 0.003370.08052 S000005159IES2YNL215WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.003370.08052&radic S000001195SPO12YHR152WverifiedNucleolar protein of unknown function, positive regulator ofexit from mitosis; involved in regulating therelease of Cdc14p from the nucleolus in earlyanaphase; proposed to play similar role inmeiosis 0.003340.07959&radic S000004826CEF1YMR213WverifiedEssential splicing factor; associated with Prp19p and thespliceosome, contains an N-terminal c-Myb DNAbinding motif necessary for cell viability butnot for Prp19p association, evolutionarilyconserved and homologous to S. pombe Cdc5p 0.003320.0786&radic S000001497URB1YKL014CverifiedNucleolar protein required for the normal accumulation of 25Sand 5.8S rRNAs, associated with the 27SA2pre-ribosomal particle; proposed to be involvedin the biogenesis of the 60S ribosomal subunit 0.003320.0786 S000005133SRP1YNL189WverifiedKaryopherin alpha homolog, forms a dimer with karyopherin betaKap95p to mediate import of nuclear proteins,binds the nuclear localization signal of thesubstrate during import; may also play a rolein regulation of protein degradation 0.003310.0786 S000000030PRP45YAL032CverifiedProtein required for pre-mRNA splicing; associates with thespliceosome and interacts with splicing factorsPrp22p and Prp46p; orthologous to humantranscriptional coactivator SKIP and canactivate transcription of a reporter gene 0.003310.0786&radic S000001111RRP4YHR069CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp41p, Rrp42p,Rrp43p and Dis3p 0.003320.0786&radic S000001176WSS1YHR134WverifiedSumoylated protein of unknown function, identified based ongenetic interactions with SMT3; UV-sensitivemutant phenotype and genetic interactionssuggest a role in the DNA damage response,processing stalled or collapsed replicationforks 0.003320.0786 S000001131GAR1YHR089CverifiedProtein component of the H/ACA snoRNP pseudouridylase complex,involved in the modification and cleavage ofthe 18S pre-rRNA 0.003310.0786 S000006323CLB2YPR119WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the transition from G2 to Mphase; accumulates during G2 and M, thentargeted via a destruction box motif forubiquitin-mediated degradation by theproteasome 0.00330.07829&radic S000002209LHP1YDL051WverifiedRNA binding protein required for maturation of tRNA and snRNAprecursors; acts as a molecular chaperone forRNAs transcribed by polymerase III; homologousto human La (SS-B) autoantigen 0.003310.07829&radic S000001323SNP1YIL061CverifiedComponent of U1 snRNP required for mRNA splicing viaspliceosome; may interact with poly(A)polymerase to regulate polyadenylation; homologof human U1 70K protein 0.00330.07829&radic S000003336SRB5YGR104CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation; involved intelomere maintenance 0.003290.07761&radic S000001185RPC10YHR143W-AverifiedRNA polymerase subunit, found in RNA polymerase complexes I,II, and III 0.003290.07761 S000006125HRR25YPL204WverifiedProtein kinase involved in regulating diverse events includingvesicular trafficking, gene expression, DNArepair, and chromosome segregation; binds theCTD of RNA pol II; homolog of mammalian caseinkinase 1delta (CK1delta) 0.003290.07761&radic S000004868GFD1YMR255WverifiedCoiled-coiled protein of unknown function, identified as ahigh-copy suppressor of a dbp5 mutation 0.003290.07761 S000002897SLD5YDR489WverifiedSubunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), whichis localized to DNA replication origins andimplicated in assembly of the DNA replicationmachinery 0.003290.07761 S000000872RNR1YER070WverifiedRibonucleotide-diphosphate reductase (RNR), large subunit; theRNR complex catalyzes the rate-limiting step indNTP synthesis and is regulated by DNAreplication and DNA damage checkpoint pathwaysvia localization of the small subunits 0.003290.07761 S000003666URA2YJL130CverifiedBifunctional carbamoylphosphate synthetase (CPSase)-aspartatetranscarbamylase (ATCase), catalyzes the firsttwo enzymatic steps in the de novo biosynthesisof pyrimidines; both activities are subject tofeedback inhibition by UTP 0.003280.07689 S000002419RPL4BYDR012WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl4Ap and has similarity to E.coli L4 and rat L4 ribosomal proteins 0.003270.07689 S000003152STR3YGL184CverifiedCystathionine beta-lyase, converts cystathionine intohomocysteine 0.003270.07689&radic S000003968RPL8BYLL045CverifiedRibosomal protein L4 of the large (60S) ribosomal subunit,nearly identical to Rpl8Ap and has similarityto rat L7a ribosomal protein; mutation resultsin decreased amounts of free 60S subunits 0.003280.07689 S000003828YAE1YJR067CverifiedEssential protein of unknown function 0.003270.07689&radic S000004377SWC7YLR385CverifiedProtein of unknown function, component of the Swr1p complexthat incorporates Htz1p into chromatin 0.003270.07689&radic S000004538RPL6AYML073CverifiedN-terminally acetylated protein component of the large (60S)ribosomal subunit, has similarity to Rpl6Bp andto rat L6 ribosomal protein; binds to 5.8S rRNA 0.003270.07689 S000002368CWC2YDL209CverifiedProtein involved in pre-mRNA splicing, component of a complexcontaining Cef1p; interacts with Prp19p;contains an RNA recognition motif; hassimilarity to S. pombe Cwf2p 0.003270.07689&radic S000006257YPR053CDubiousHypothetical protein 0.003270.07689 S000006222RLF2YPR018WverifiedLargest subunit (p90) of the Chromatin Assembly Complex (CAF-I)with Cac2p and Msi1p that assembles newlysynthesized histones onto recently replicatedDNA; involved in the maintenance oftranscriptionally silent chromatin 0.003260.07684 S000000612MAK32YCR019WverifiedProtein necessary for structural stability of L-Adouble-stranded RNA-containing particles 0.003260.07626 S000003388PTI1YGR156WverifiedPta1p Interacting protein 0.003250.07626&radic S000004187SIK1YLR197WverifiedEssential evolutionarily-conserved nucleolar protein componentof the box C/D snoRNP complexes that direct2'-O-methylation of pre-rRNA during itsmaturation; overexpression causes spindleorientation defects 0.003260.07626 S000000451ENP1YBR247CverifiedProtein associated with U3 and U14 snoRNAs, required forpre-rRNA processing and 40S ribosomal subunitsynthesis; localized in the nucleus andconcentrated in the nucleolus 0.003250.07626&radic S000003506TAF1YGR274CverifiedTFIID subunit (145 kDa), involved in RNA polymerase IItranscription initiation, has histoneacetyltransferase activity, involved inpromoter binding and G1/S progression 0.003260.07626&radic S000000010CYS3YAL012WverifiedCystathionine gamma-lyase, catalyzes one of the two reactionsinvolved in the transsulfuration pathway thatyields cysteine from homocysteine with theintermediary formation of cystathionine 0.003260.07626 S000001886SMC1YFL008WverifiedSubunit of the multiprotein cohesin complex, essential proteininvolved in chromosome segregation and indouble-strand DNA break repair; SMC chromosomalATPase family member, binds DNA with apreference for DNA with secondary structure 0.003250.07626&radic S000004529TEM1YML064CverifiedGTP-binding protein of the ras superfamily involved intermination of M-phase; controls actomyosin andseptin dynamics during cytokinesis 0.003250.07626 S000004550TUB1YML085CverifiedAlpha-tubulin; associates with beta-tubulin (Tub2p) to formtubulin dimer, which polymerizes to formmicrotubules 0.003240.07614 S000004855RPL20AYMR242CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl20Bp and has similarity to ratL18a ribosomal protein 0.003230.07547 S000003452MRPL9YGR220CverifiedMitochondrial ribosomal protein of the large subunit 0.003230.07547 S000006365SGV1YPR161CverifiedCyclin (Bur2p)-dependent protein kinase that functions intranscriptional regulation; phosphorylates thecarboxy-terminal domain of Rpo21p, which is thelargest subunit of RNA polymerase II; regulatedby Cak1p 0.003220.07547&radic S000002198NAT1YDL040CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.003230.07547 S000001540NUP120YKL057CverifiedSubunit of the Nup84p subcomplex of the nuclear pore complex(NPC), required for even distribution of NPCsaround the nuclear envelope, involved inestablishment of a normal nucleocytoplasmicconcentration gradient of the GTPase Gsp1p 0.003230.07547&radic S000007283COX3Q0275verifiedSubunit III of cytochrome c oxidase, which is the terminalmember of the mitochondrial inner membraneelectron transport chain; one of threemitochondrially-encoded subunits 0.003220.07547 S000003767SUI2YJR007WverifiedAlpha subunit of the translation initiation factor eIF2,involved in the identification of the startcodon; phosphorylation of Ser51 is required forregulation of translation by inhibiting theexchange of GDP for GTP 0.003230.07547 S000000517GBP2YCL011CverifiedPoly(A+) RNA-binding protein, involved in the export of mRNAsfrom the nucleus to the cytoplasm; similar toHrb1p and Npl3p; also binds single-strandedtelomeric repeat sequence in vitro 0.003220.07547&radic S000002260CDC2YDL102WverifiedCatalytic subunit of DNA polymerase delta; required forchromosomal DNA replication during mitosis andmeiosis, intragenic recombination, repair ofdouble strand DNA breaks, and DNA replicationduring nucleotide excision repair (NER) 0.003230.07547&radic S000000019CCR4YAL021CverifiedComponent of the CCR4-NOT transcriptional complex, which isinvolved in regulation of gene expression;component of the major cytoplasmic deadenylase,which is involved in mRNA poly(A) tailshortening 0.003210.07526 S000001532CSE4YKL049CverifiedCentromere protein that resembles histones, required for properkinetochore function; homolog of human CENP-A 0.003210.07526&radic S000005674SPP2YOR148CverifiedEssential protein that promotes the first step of splicing andis required for the final stages of spliceosomematuration; interacts with Prp2p, which mayrelease Spp2p from the spliceosome followingthe first cleavage reaction 0.003190.07428&radic S000003193VRG4YGL225WverifiedGolgi GDP-mannose transporter; regulates Golgi function andglycosylation in Golgi 0.00320.07428 S000000631RRP43YCR035CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp41p, Rrp42p,Rrp4p and Dis3p; required for efficientmaturation of 5.8S, 18S and 25S rRNA 0.00320.07428&radic S000001440SGN1YIR001CverifiedCytoplasmic RNA-binding protein, contains an RNA recognitionmotif (RRM); may have a role in mRNAtranslation, as suggested by geneticinteractions with genes encoding proteinsinvolved in translational initiation 0.003210.07428 S000003206HAP2YGL237CverifiedSubunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5pCCAAT-binding complex, a transcriptionalactivator and global regulator of respiratorygene expression; contains sequences sufficientfor both complex assembly and DNA binding 0.00320.07428&radic S000000967PAB1YER165WverifiedPoly(A) binding protein, part of the 3'-end RNA-processingcomplex, mediates interactions between the 5'cap structure and the 3' mRNA poly(A) tail,involved in control of poly(A) tail length,interacts with translation factor eIF-4G 0.003190.07428 S000000417MET8YBR213WverifiedBifunctional dehydrogenase and ferrochelatase, involved in thebiosynthesis of siroheme; also involved in theexpression of PAPS reductase and sulfitereductase 0.003180.07415 S000000392NTC20YBR188CverifiedMember of a complex, including Prp19p, that binds to thespliceosome; required for pre-mRNA splicing 0.003180.07415&radic S000005509DCP1YOL149WverifiedSubunit of the Dcp1p-Dcp2p decapping enzyme complex, whichremoves the 5' cap structure from mRNAs priorto their degradation; enhances the activity ofcatalytic subunit Dcp2p; regulated by DEAD boxprotein Dhh1p 0.003170.07357 S000002827RAD30YDR419WverifiedDNA polymerase eta, involved in the predominantly error-freebypass replication of DNA lesions, catalyzesthe efficient and accurate synthesis of DNAopposite cyclobutane pyrimidine dimers; homologof human POLH and bacterial DinB proteins 0.003170.07357&radic S000001622CTK1YKL139WverifiedCatalytic (alpha) subunit of C-terminal domain kinase I(CTDK-I), which phosphorylates the C-terminalrepeated domain of the RNA polymerase II largesubunit (Rpo21p) to affect both transcriptionand pre-mRNA 3' end processing 0.003170.07357&radic S000006085MLH3YPL164CverifiedProtein involved in DNA mismatch repair; forms a complex withMlh1p to promote meiotic crossing-over;mammalian homolog is implicated mammalianmicrosatellite instability 0.003150.07235 S000005062DCP2YNL118CverifiedCatalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex,which removes the 5' cap structure from mRNAsprior to their degradation; member of the Nudixhydrolase family 0.003160.07235 S000002104RPL2AYFR031C-AverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl2Bp and has similarity to E.coli L2 and rat L8 ribosomal proteins 0.003140.07235 S000003318PIL1YGR086CverifiedPrimary component of eisosomes, which are large immobile patchstructures at the cell cortex associated withendocytosis, along with Lsp1p and Sur7p; nullmutants show activation of Pkc1p/Ypk1p stressresistance pathways 0.003130.07235 S000002603REF2YDR195WverifiedRNA-binding protein involved in the cleavage step of mRNA3'-end formation prior to polyadenylation, andin snoRNA maturation; part of holo-CPFsubcomplex APT, which associates with 3'-endsof snoRNA- and mRNA-encoding genes 0.003140.07235&radic S000004310EST2YLR318WverifiedReverse transcriptase subunit of the telomerase holoenzyme,essential for telomerase core catalyticactivity, involved in other aspects oftelomerase assembly and function; mutations inhuman homolog are associated with aplasticanemia 0.003130.07235 S000004033TRX1YLR043CverifiedCytoplasmic thioredoxin isoenzyme of the thioredoxin systemwhich protects cells against both oxidative andreductive stress, forms LMA1 complex withPbi2p, acts as a cofactor for Tsa1p, requiredfor ER-Golgi transport and vacuole inheritance 0.003130.07235&radic S000000935GLC7YER133WverifiedCatalytic subunit of type 1 serine/threonine proteinphosphatase, involved in many processesincluding glycogen metabolism, sporulation, andmitosis; interacts with multiple regulatorysubunits; predominantly isolated with Sds22p 0.003150.07235&radic S000004806MRPL24YMR193WverifiedMitochondrial ribosomal protein of the large subunit 0.003130.07235 S000001331RPS24BYIL069CverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps24Ap and has similarity to ratS24 ribosomal protein 0.003140.07235 S000000566MRC1YCL061CverifiedS-phase checkpoint protein found at replication forks, requiredfor DNA replication; also required for Rad53pactivation during DNA replication stress, whereit forms a replication-pausing complex withTof1p and is phosphorylated by Mec1p; proteininvolved in replication checkpoint 0.003160.07235&radic S000001025RPL8AYHL033CverifiedRibosomal protein L4 of the large (60S) ribosomal subunit,nearly identical to Rpl8Bp and has similarityto rat L7a ribosomal protein; mutation resultsin decreased amounts of free 60S subunits 0.003140.07235 S000003287MUP1YGR055WverifiedHigh affinity methionine permease, integral membrane proteinwith 13 putative membrane-spanning regions;also involved in cysteine uptake 0.003150.07235 S000002447ENA1YDR040CverifiedP-type ATPase sodium pump, involved in Na+ and Li+ efflux toallow salt tolerance 0.00310.07126 S000000036CDC19YAL038WverifiedPyruvate kinase, functions as a homotetramer in glycolysis toconvert phosphoenolpyruvate to pyruvate, theinput for aerobic (TCA cycle) or anaerobic(glucose fermentation) respiration 0.003110.07126 S000003163GCN1YGL195WverifiedPositive regulator of the Gcn2p kinase activity, forms acomplex with Gcn20p; proposed to stimulateGcn2p activation by an uncharged tRNA 0.00310.07126 S000000802YEL076CUncharacterizedHypothetical protein 0.003120.07126 S000005554CIN5YOR028CverifiedBasic leucine zipper transcriptional factor of the yAP-1 familythat mediates pleiotropic drug resistance andsalt tolerance; localizes constitutively to thenucleus 0.003120.07126&radic S000001537DEF1YKL054CverifiedRNAPII degradation factor, forms a complex with Rad26p inchromatin, enables ubiquitination andproteolysis of RNAPII present in an elongationcomplex 0.003120.07126 S000002701SSD1YDR293CverifiedProtein with a role in maintenance of cellular integrity,interacts with components of the TOR pathway;ssd1 mutant of a clinical S. cerevisiae straindisplays elevated virulence 0.003110.07126 S000003272KSS1YGR040WverifiedMitogen-activated protein kinase (MAPK) involved in signaltransduction pathways that control filamentousgrowth and pheromone response 0.003120.07126&radic S000005217TOF1YNL273WverifiedSubunit of a replication-pausing checkpoint complex(Tof1p-Mrc1p-Csm3p) that acts at the stalledreplication fork to promote sister chromatidcohesion after DNA damage, facilitating gaprepair of damaged DNA; interacts with the MCMhelicase 0.003120.07126&radic S000000381EHT1YBR177CverifiedAcyl-coenzymeA:ethanol O-acyltransferase that plays a minorrole in medium-chain fatty acid ethyl esterbiosynthesis; contains esterase activity;localizes to lipid particles and themitochondrial outer membrane 0.00310.07113 S000006141RPL1AYPL220WverifiedN-terminally acetylated protein component of the large (60S)ribosomal subunit, nearly identical to Rpl1Bpand has similarity to E. coli L1 and rat L10aribosomal proteins; rpl1a rpl1b double nullmutation is lethal 0.003090.07097 S000005480RPL18AYOL120CverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl18Bp and has similarity to ratL18 ribosomal protein; intron of RPL18Apre-mRNA forms stem-loop structures that are atarget for Rnt1p cleavage leading todegradation 0.003090.07097 S000003098CEG1YGL130WverifiedAlpha (guanylyltransferase) subunit of the mRNA capping enzyme,a heterodimer (the other subunit is CET1, anRNA 5'-triphophatase) involved in adding the 5'cap to mRNA; the mammalian enzyme is a singlebifunctional polypeptide 0.003090.07097&radic S000005820RRS1YOR294WverifiedEssential protein that binds ribosomal protein L11 and isrequired for nuclear export of the 60Spre-ribosomal subunit during ribosomebiogenesis; mouse homolog shows alteredexpression in Huntington's disease model mice 0.003090.07076 S000005837NOP58YOR310CverifiedProtein involved in pre-rRNA processing, 18S rRNA synthesis,and snoRNA synthesis; component of the smallsubunit processome complex, which is requiredfor processing of pre-18S rRNA 0.003080.07076 S000003096CWC23YGL128CverifiedComponent of a complex containing Cef1p, putatively involved inpre-mRNA splicing; has similarity to E. coliDnaJ and other DnaJ-like proteins and to S.pombe Cwf23p 0.003090.07076&radic S000003781YJR020WDubiousHypothetical protein 0.003080.07047 S000006379DPB2YPR175WverifiedSecond largest subunit of DNA polymerase II (DNA polymeraseepsilon), required for normal yeast chromosomalreplication; expression peaks at the G1/S phaseboundary; potential Cdc28p substrate 0.003080.07047&radic S000007235SEM1YDR363W-AverifiedComponent of the lid subcomplex of the regulatory subunit ofthe 26S proteasome; ortholog of human DSS1 0.003070.07032&radic S000003135PMR1YGL167CverifiedHigh affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ andMn2+ transport into Golgi; involved in Ca2+dependent protein sorting and processing;mutations in human homolog ATP2C1 causeacantholytic skin condition Hailey-Haileydisease 0.003070.07032 S000001076PIH1YHR034CverifiedProtein of unresolved function; may function in protein foldingand/or rRNA processing, interacts with achaperone (Hsp82p), two chromatin remodelingfactors (Rvb1p, Rvb2p) and two rRNA processingfactors (Rrp43p, Nop58p) 0.003070.07032&radic S000004691YMR086C-ADubiousHypothetical protein 0.003070.07032 S000005552BUB3YOR026WverifiedKinetochore checkpoint WD40 repeat protein that localizes tokinetochores during prophase and metaphase,delays anaphase in the presence of unattachedkinetochores; forms complexes with Mad1p-Bub1pand with Cdc20p, binds Mad2p and Mad3p 0.003060.06956&radic S000001587GFA1YKL104CverifiedGlutamine-fructose-6-phosphate amidotransferase, catalyzes theformation of glucosamine-6-P and glutamate fromfructose-6-P and glutamine in the first step ofchitin biosynthesis 0.003060.06956 S000003856SFC1YJR095WverifiedMitochondrial succinate-fumarate transporter, transportssuccinate into and fumarate out of themitochondrion; required for ethanol and acetateutilization 0.003060.06956 S000003079NSA1YGL111WverifiedConstituent of 66S pre-ribosomal particles, involved in 60Sribosomal subunit biogenesis 0.003050.06956&radic S000004947RLP7YNL002CverifiedNucleolar protein with similarity to large ribosomal subunit L7proteins; constituent of 66S pre-ribosomalparticles; plays an essential role inprocessing of precursors to the large ribosomalsubunit RNAs 0.003060.06956 S000005483HRP1YOL123WverifiedSubunit of cleavage factor I, a five-subunit complex requiredfor the cleavage and polyadenylation ofpre-mRNA 3' ends; RRM-containing heteronuclearRNA binding protein and hnRNPA/B family memberthat binds to poly (A) signal sequences 0.003050.06956&radic S000005097GIM3YNL153CverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.003040.06925 S000005487RPL25YOL127WverifiedPrimary rRNA-binding ribosomal protein component of the large(60S) ribosomal subunit, has similarity to E.coli L23 and rat L23a ribosomal proteins; bindsto 26S rRNA via a conserved C-terminal motif 0.003040.06925 S000001410RPL40AYIL148WverifiedFusion protein, identical to Rpl40Bp, that is cleaved to yieldubiquitin and a ribosomal protein of the large(60S) ribosomal subunit with similarity to ratL40; ubiquitin may facilitate assembly of theribosomal protein into ribosomes 0.003040.06925&radic S000005606DIA2YOR080WverifiedOrigin-binding F-box protein that forms an SCF ubiquitin ligasecomplex with Skp1p and Cdc53p; plays a role inDNA replication, involved in invasive andpseudohyphal growth 0.003040.06925 S000001280RPL2BYIL018WverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl2Ap and has similarity to E.coli L2 and rat L8 ribosomal proteins;expression is upregulated at low temperatures 0.003040.06925<