Yfunc lets you browse current and predicted gene functions in yeast

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Prediction of GO:0004652 "polynucleotide adenylyltransferase activity"

GO branch: MF
Number of currently annotated genes: 5

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest Ho:S000002334Ho:S000001341IPR002934PF01909PF03828PF00098IPR002058PR00939IPR007010Ho:S000005475 S000005475PAP2YOL115WverifiedCatalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), anuclear poly (A) polymerase complex involved inRNA quality control; catalyzes polyadenylationof unmodified tRNAs, and snoRNA and rRNAprecursors; disputed role as a DNA polymerase &radic0.30470.93689&radic&radic&radic&radic&radic S000005243TRF5YNL299WverifiedPoly (A) polymerase involved in nuclear RNA quality controlbased on: homology with Trf4p, geneticinteractions with TRF4 mutants, physicalinteraction with Mtr4p (TRAMP subunit), and bydirect assay; disputed role as a sigma DNApolymerase &radic0.227010.92835&radic&radic&radic&radic S000001710PAP1YKR002WverifiedPoly(A) polymerase, one of three factors required for mRNA3'-end polyadenylation, forms multiproteincomplex with polyadenylation factor I (PF I),also required for mRNA nuclear export; may alsopolyadenylate rRNAs &radic0.045510.63168&radic&radic&radic S000001341AIR1YIL079CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p to regulate methylationof Npl3p, which modulates Npl3p function inmRNA processing and export; has similarity toAir2p &radic0.042120.6211&radic&radic&radic S000002334AIR2YDL175CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p; may regulatemethylation of Npl3p, which modulates Npl3pfunction in mRNA processing and export; hassimilarity to Air1p &radic0.030990.55033&radic&radic&radic S000005199GIS2YNL255CverifiedProtein with seven cysteine-rich CCHC zinc-finger motifs,similar to human CNBP, proposed to be involvedin the RAS/cAMP signaling pathway 0.02630.5185&radic&radic S000006311YTH1YPR107CverifiedEssential RNA-binding component of cleavage and polyadenylationfactor, contains five zinc fingers; requiredfor pre-mRNA 3'-end processing andpolyadenylation 0.026040.51702 S000004106MSL5YLR116WverifiedComponent of the commitment complex, which defines the firststep in the splicing pathway; essential proteinthat interacts with Mud2p and Prp40p, forming abridge between the intron ends; also involvedin nuclear retention of pre-mRNA 0.025230.51181&radic&radic S000002495SLU7YDR088CverifiedRNA splicing factor, required for ATP-independent portion of2nd catalytic step of spliceosomal RNAsplicing; interacts with Prp18p; contains zincknuckle domain 0.022930.49117&radic&radic S000001542MPE1YKL059CverifiedEssential conserved subunit of CPF (cleavage andpolyadenylation factor), plays a role in 3' endformation of mRNA via the specific cleavage andpolyadenylation of pre-mRNA, contains aputative RNA-binding zinc knuckle motif 0.019950.45981 S000000939YER137CUncharacterizedHypothetical protein 0.01090.34561&radic S000005898GPB1YOR371CverifiedProposed beta subunit of the heterotrimeric G protein;interacts with the receptor Grp1p, affectssignaling by altering the level ofphosphorylation of PKS substrates; regulatespseudohyphal growth through cAMP levels;homolog of Gpb2p 0.004720.21428 S000003586MTR4YJL050WverifiedDead-box family ATP dependent helicase required for mRNA exportfrom the nucleus; co-factor of the exosomecomplex, required for 3' end formation of 5.8SrRNA 3e-050.0019 S000004105CFT2YLR115WverifiedSubunit of the mRNA cleavage and polyadenlylation factor (CPF);required for pre-mRNA cleavage, polyadenylationand poly(A) site recognition, 43% similaritywith the mammalian CPSF-100 protein. 3e-050.00186 S000000041PTA1YAL043CverifiedSubunit of holo-CPF, a multiprotein complex and functionalhomolog of mammalian CPSF, required for thecleavage and polyadenylation of mRNA and snoRNA3' ends; involved in pre-tRNA processing; bindsto the phosphorylated CTD of RNAPII 3e-050.00185 S000000120NCL1YBL024WverifiedS-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase,methylates cytosine to m5C at several positionsin tRNAs and intron-containing pre-tRNAs;similar to Nop2p and human proliferationassociated nucleolar protein p120 2e-050.00177 S000003062PAN2YGL094CverifiedEssential subunit of the Pan2p-Pan3p poly(A)-ribonucleasecomplex, which acts to control poly(A) taillength and regulate the stoichiometry andactivity of postreplication repair complexes 2e-050.00174 S000003719MNN11YJL183WverifiedSubunit of a Golgi mannosyltransferase complex that alsocontains Anp1p, Mnn9p, Mnn10p, and Hoc1p, andmediates elongation of the polysaccharidemannan backbone; has homology to Mnn10p 2e-050.00174 S000000744EAF5YEL018WuncharacterizedEsa1p-associated factor, subunit of the NuA4 acetyltransferasecomplex 2e-050.00174 S000001234CTF8YHR191CverifiedSubunit of a complex with Ctf18p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion 2e-050.00174 S000005831ISW2YOR304WverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPasecomponent that, with Itc1p, forms a complexrequired for repression of a-specific genes,INO1, and early meiotic genes during mitoticgrowth 2e-050.00174 S000004181PEX13YLR191WverifiedIntegral peroxisomal membrane receptor for the PTS1 peroxisomalmatrix protein signal recognition factor Pex5p,required for the translocation of peroxisomalmatrix proteins, also interacts with Pex7p andPex14p, contains a C-terminal SH3 domain 2e-050.00174 S000004844PEP5YMR231WverifiedPeripheral vacuolar membrane protein required for proteintrafficking and vacuole biogenesis; formscomplex with Pep3p that promotes vesiculardocking/fusion reactions in conjunction withSNARE proteins, also interacts with Pep7p 2e-050.00174 S000004187SIK1YLR197WverifiedEssential evolutionarily-conserved nucleolar protein componentof the box C/D snoRNP complexes that direct2'-O-methylation of pre-rRNA during itsmaturation; overexpression causes spindleorientation defects 2e-050.00169 S000003280UFD1YGR048WverifiedProtein that interacts with Cdc48p and Npl4p, involved inrecognition of polyubiquitinated proteins andtheir presentation to the 26S proteasome fordegradation; involved in transporting proteinsfrom the ER to the cytosol 2e-050.00169 S000004949HRB1YNL004WverifiedPoly(A+) RNA-binding protein, involved in the export of mRNAsfrom the nucleus to the cytoplasm; similar toGbp2p and Npl3p 2e-050.00169 S000000631RRP43YCR035CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp41p, Rrp42p,Rrp4p and Dis3p; required for efficientmaturation of 5.8S, 18S and 25S rRNA 2e-050.00169 S000003095SOH1YGL127CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; involved in telomeremaintenance; conserved with other metazoanMED31 subunits 2e-050.00169 S000002430SES1YDR023WverifiedCytosolic seryl-tRNA synthetase, class II aminoacyl-tRNAsynthetase that aminoacylates tRNA(Ser),displays tRNA-dependent amino acid recognitionwhich enhances discrimination of the serinesubstrate, interacts with peroxin Pex21p 2e-050.00169 S000001927SMC2YFR031CverifiedComponent of the condensin complex, essential SMC chromosomalATPase family member that forms a complex withSmc4p to form the active ATPase; Smc2p/Smc4pcomplex binds DNA, possibly in the cleft formedby the coiled-coil of the folded dimer 2e-050.00169 S000005527RRP6YOR001WverifiedExonuclease component of the nuclear exosome; contributes tothe quality-control system that retains anddegrades aberrant mRNAs in the nucleus 2e-050.00169 S000000455MRPS5YBR251WverifiedMitochondrial ribosomal protein of the small subunit 2e-050.00169 S000006395QCR2YPR191WverifiedSubunit 2 of the ubiquinol cytochrome-c reductase complex,which is a component of the mitochondrial innermembrane electron transport chain;transcription is regulated by Hap1p,Hap2p/Hap3p, and heme 2e-050.00169 S000005552BUB3YOR026WverifiedKinetochore checkpoint WD40 repeat protein that localizes tokinetochores during prophase and metaphase,delays anaphase in the presence of unattachedkinetochores; forms complexes with Mad1p-Bub1pand with Cdc20p, binds Mad2p and Mad3p 2e-050.00166 S000001501SWD2YKL018WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lys 4 and is involved intelomeric silencing; subunit of CPF (cleavageand polyadenylation factor), a complex involvedin RNAP II transcription termination 2e-050.00166 S000002840NPL3YDR432WverifiedRNA-binding protein that carries poly(A)+ mRNA from the nucleusinto the cytoplasm; phosphorylation by Sky1p inthe cytoplasm may promote release of mRNAs 2e-050.00166 S000003797HUL4YJR036CverifiedProtein with similarity to hect domain E3 ubiquitin-proteinligases, not essential for viability 2e-050.00166 S000003853FIP1YJR093CverifiedSubunit of cleavage polyadenylation factor (CPF), interactsdirectly with poly(A) polymerase (Pap1p) toregulate its activity 2e-050.00166 S000004925PSE1YMR308CverifiedKaryopherin/importin that interacts with the nuclear porecomplex; acts as the nuclear import receptorfor specific proteins, including Pdr1p, Yap1p,Ste12p, and Aft1p 2e-050.00166 S000006111NAB3YPL190CverifiedSingle stranded DNA binding protein; acidic ribonucleoprotein;required for termination of non-poly(A)transcripts and efficient splicing; interactswith Nrd1p 2e-050.00164 S000004409VPS36YLR417WverifiedComponent of the ESCRT-II complex; contains the GLUE (GRAM LikeUbiquitin binding in EAP45) domain which isinvolved in interactions with ESCRT-I andubiquitin-dependent sorting of proteins intothe endosome 2e-050.00164 S000005372HTZ1YOL012CverifiedHistone variant H2AZ, exchanged for histone H2A in nucleosomesby the SWR1 complex; involved intranscriptional regulation through preventionof the spread of silent heterochromatin 2e-050.00164 S000000929LCP5YER127WverifiedEssential protein involved in maturation of 18S rRNA; depletionleads to inhibited pre-rRNA processing andreduced polysome levels; localizes primarily tothe nucleolus 2e-050.00164 S000004349RSC2YLR357WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; involvedin telomere maintenance 2e-050.00164 S000001123LRP1YHR081WverifiedSubstrate-specific nuclear cofactor for exosome activity in theprocessing of stable RNAs; required fortelomere length maintenance; homolog ofmammalian nuclear matrix protein C1D involvedin regulation of DNA repair and recombination 2e-050.00164 S000002536SAC6YDR129CverifiedFimbrin, actin-bundling protein; cooperates with Scp1p(calponin/transgelin) in the organization andmaintenance of the actin cytoskeleton 2e-050.00164 S000004520IMD4YML056CverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 2e-050.00164 S000004984BDP1YNL039WverifiedEssential subunit of RNA polymerase III transcription factor(TFIIIB), which is involved in transcription ofgenes encoding tRNAs, 5S rRNA, U6 snRNA, andother small RNAs 2e-050.0016 S000005366TOP1YOL006CverifiedTopoisomerase I, nuclear enzyme that relieves torsional strainin DNA by cleaving and re-sealing thephosphodiester backbone; relaxes bothpositively and negatively supercoiled DNA;functions in replication, transcription, andrecombination 2e-050.0016 S000005356YNR073CUncharacterizedHypothetical protein 2e-050.0016 S000002709CFT1YDR301WverifiedRNA-binding subunit of the mRNA cleavage and polyadenylationfactor; involved in poly(A) site recognitionand required for both pre-mRNA cleavage andpolyadenylation, 51% sequence similarity withmammalian AAUAA-binding subunit of CPSF 1e-050.00157 S000000514STP22YCL008CverifiedComponent of the ESCRT-I complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; homologous to the mouse and humanTsg101 tumor susceptibility gene; mutantsexhibit a Class E Vps phenotype 1e-050.00157 S000004267YSH1YLR277CverifiedPutative endonuclease, subunit of the mRNA cleavage andpolyadenylation specificity complex requiredfor 3' processing of mRNAs 1e-050.00157 S000005261PFS2YNL317WverifiedIntegral subunit of the pre-mRNA cleavage and polyadenylationfactor (CPF) complex; plays an essential rolein mRNA 3'-end formation by bridging differentprocessing factors and thereby promoting theassembly of the processing complex 1e-050.00157 S000002636PCF11YDR228CverifiedmRNA 3' end processing factor, essential component of cleavageand polyadenylation factor IA (CF IA), involvedin pre-mRNA 3' end processing and intranscription termination; binds C-terminaldomain of largest subunit of RNA pol II(Rpo21p) 1e-050.00155 S000003397MRPS35YGR165WverifiedMitochondrial ribosomal protein of the small subunit 1e-050.00155 S000004842RRP5YMR229CverifiedProtein required for the synthesis of both 18S and 5.8S rRNA;C-terminal region is crucial for the formationof 18S rRNA and N-terminal region is requiredfor the 5.8S rRNA; component of small ribosomalsubunit (SSU) processosome 1e-050.00155 S000004312MMS22YLR320WverifiedProtein involved in resistance to ionizing radiation; acts withMms1p in a repair pathway that may be involvedin resolving replication intermediates orpreventing the damage caused by blockedreplication forks 1e-050.00155 S000005206POL2YNL262WverifiedCatalytic subunit of DNA polymerase epsilon, one of the majorchromosomal DNA replication polymerasescharacterized by processivity and proofreadingexonuclease activity; also involved in DNAsynthesis during DNA repair 1e-050.00155 S000000818BIM1YER016WverifiedMicrotubule-binding protein that together with Kar9p makes upthe cortical microtubule capture site anddelays the exit from mitosis when the spindleis oriented abnormally 1e-050.00155 S000004918ADH2YMR303CverifiedGlucose-repressible alcohol dehydrogenase II, catalyzes theconversion of ethanol to acetaldehyde; involvedin the production of certain carboxylateesters; regulated by ADR1 1e-050.00155 S000002545HPR1YDR138WverifiedSubunit of THO/TREX complexes that couple transcriptionelongation with mitotic recombination and withmRNA metabolism and export, subunit of an RNAPol II complex; regulates lifespan; involved intelomere maintenance; similar to Top1p 1e-050.00152 S000000322TEF2YBR118WverifiedTranslational elongation factor EF-1 alpha; also encoded byTEF1; functions in the binding reaction ofaminoacyl-tRNA (AA-tRNA) to ribosomes 1e-050.00152 S000000673PAT1YCR077CverifiedTopoisomerase II-associated deadenylation-dependentmRNA-decapping factor; also required forfaithful chromosome transmission, maintenanceof rDNA locus stability, and protection of mRNA3'-UTRs from trimming; functionally linked toPab1p 1e-050.00152 S000005952PHO85YPL031CverifiedCyclin-dependent kinase, with ten cyclin partners; involved inenvironmental stress response; inphosphate-rich conditions, Pho85p-Pho80pcomplex phosphorylates Pho4p which in turnrepresses PHO5 1e-050.00152 S000005056DBP2YNL112WverifiedEssential ATP-dependent RNA helicase of the DEAD-box proteinfamily, involved in nonsense-mediated mRNAdecay and rRNA processing 1e-050.00152 S000006379DPB2YPR175WverifiedSecond largest subunit of DNA polymerase II (DNA polymeraseepsilon), required for normal yeast chromosomalreplication; expression peaks at the G1/S phaseboundary; potential Cdc28p substrate 1e-050.00152 S000000638TAF2YCR042CverifiedTFIID subunit (150 kDa), involved in RNA polymerase IItranscription initiation 1e-050.00152 S000005143GCR2YNL199CverifiedTranscriptional activator of genes involved in glycolysis;interacts and functions with the DNA-bindingprotein Gcr1p 1e-050.00152 S000001596RAD27YKL113Cverified5' to 3' exonuclease, 5' flap endonuclease, required forOkazaki fragment processing and maturation aswell as for long-patch base-excision repair;member of the S. pombe RAD2/FEN1 family 1e-050.00152 S000004577ZDS2YML109WverifiedProtein that interacts with silencing proteins at the telomere,involved in transcriptional silencing; paralogof Zds1p 1e-050.00152 S000004886ZDS1YMR273CverifiedProtein that interacts with silencing proteins at the telomere,involved in transcriptional silencing; has arole in localization of Bcy1p, a regulatorysubunit of protein kinase A; implicated in mRNAnuclear export 1e-050.00152 S000005051YAF9YNL107WverifiedSubunit of both the NuA4 histone H4 acetyltransferase complexand the SWR1 complex, may function toantagonize silencing near telomeres; interactsdirectly with Swc4p, has homology to humanleukemogenic protein AF9, contains a YEATSdomain 1e-050.00152 S000000770IES6YEL044WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 1e-050.00152 S000000301VPS15YBR097WverifiedMyristoylated serine/threonine protein kinase involved invacuolar protein sorting; functions as amembrane-associated complex with Vps34p; activeform recruits Vps34p to the Golgi membrane;interacts with the GDP-bound form of Gpa1p 1e-050.00152 S000002798UBA2YDR390CverifiedNuclear protein that acts as a heterodimer with Aos1p toactivate Smt3p (SUMO) before its conjugation toproteins (sumoylation), which may play a rolein protein targeting; essential for viability 1e-050.00145 S000003406CBP4YGR174CverifiedMitochondrial protein required for assembly of ubiquinolcytochrome-c reductase complex (cytochrome bc1complex); interacts with Cbp3p and function ispartially redundant with that of Cbp3p 1e-050.00145 S000003660LSM1YJL124CverifiedLsm (Like Sm) protein; forms heteroheptameric complex (withLsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p)involved in degradation of cytoplasmic mRNAs 1e-050.00145 S000003506TAF1YGR274CverifiedTFIID subunit (145 kDa), involved in RNA polymerase IItranscription initiation, has histoneacetyltransferase activity, involved inpromoter binding and G1/S progression 1e-050.00145 S000004045SPT8YLR055CverifiedSubunit of the SAGA transcriptional regulatory complex but notpresent in SAGA-like complex SLIK/SALSA,required for SAGA-mediated inhibition at somepromoters 1e-050.00143 S000002544RGP1YDR137WverifiedSubunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) thatcatalyzes nucleotide exchange on Ypt6p 1e-050.00143 S000003063VPS45YGL095CverifiedProtein of the Sec1p/Munc-18 family, essential for vacuolarprotein sorting; required for the function ofPep12p and the early endosome/late Golgi SNARETlg2p; essential for fusion of Golgi-derivedvesicles with the prevacuolar compartment 1e-050.00143 S000006392MLC2YPR188CuncharacterizedRegulatory light chain for the type II myosin, Myo1p; binds toan IQ motif of Myo1p, localization to the budneck depends on Myo1p; involved in thedisassembly of the Myo1p ring 1e-050.00143 S000001073RRM3YHR031CverifiedDNA helicase involved in rDNA replication and Ty1transposition; relieves replication fork pausesat telomeric regions; structurally andfunctionally related to Pif1p 1e-050.00143 S000002847LRS4YDR439WverifiedProtein involved in rDNA silencing; positively chargedcoiled-coil protein with limited similarity tomyosin 1e-050.00143 S000004252YPT6YLR262CverifiedGTPase, Ras-like GTP binding protein involved in the secretorypathway, required for fusion ofendosome-derived vesicles with the late Golgi,maturation of the vacuolar carboxypeptidase Y;has similarity to the human GTPase, Rab6 1e-050.00143 S000004467ERG6YML008CverifiedDelta(24)-sterol C-methyltransferase, converts zymosterol tofecosterol in the ergosterol biosyntheticpathway by methylating position C-24; localizedto both lipid particles and mitochondrial outermembrane 1e-050.00143 S000005133SRP1YNL189WverifiedKaryopherin alpha homolog, forms a dimer with karyopherin betaKap95p to mediate import of nuclear proteins,binds the nuclear localization signal of thesubstrate during import; may also play a rolein regulation of protein degradation 1e-050.00143 S000005730DED1YOR204WverifiedATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, requiredfor translation initiation of all yeast mRNAs;mutations in human DEAD-box DBY are a frequentcause of male infertility 1e-050.00143 S000005195NRD1YNL251CverifiedRNA-binding protein that interacts with the C-terminal domainof the RNA polymerase II large subunit(Rpo21p), required for transcriptiontermination and 3' end maturation ofnonpolyadenylated RNAs 1e-050.00143 S000004029RIC1YLR039CverifiedProtein involved in retrograde transport to the cis-Golginetwork; forms heterodimer with Rgp1p that actsas a GTP exchange factor for Ypt6p; involved intranscription of rRNA and ribosomal proteingenes 1e-050.00143 S000000238HMT1YBR034CverifiedNuclear SAM-dependent mono- and asymmetric argininedimethylating methyltransferase that modifieshnRNPs, including Npl3p and Hrp1p, thusfacilitating nuclear export of these proteins;required for viability of npl3 mutants 1e-050.00143 S000003088PRP43YGL120CverifiedRNA helicase in the DEAH-box family, functions in both RNApolymerase I and polymerase II transcriptmetabolism, involved in release of thelariat-intron from the spliceosome 1e-050.00141 S000003746PEX2YJL210WverifiedRING-finger peroxin, peroxisomal membrane protein with aC-terminal zinc-binding RING domain, formsputative translocation subcomplex with Pex10pand Pex12p which functions in peroxisomalmatrix protein import 1e-050.00141 S000006177CLN2YPL256CverifiedG1 cyclin involved in regulation of the cell cycle; activatesCdc28p kinase to promote the G1 to S phasetransition; late G1 specific expression dependson transcription factor complexes, MBF(Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) 1e-050.00141 S000004682VPS20YMR077CverifiedMyristoylated subunit of ESCRTIII, the endosomal sortingcomplex required for transport of transmembraneproteins into the multivesicular body pathwayto the lysosomal/vacuolar lumen; cytoplasmicprotein recruited to endosomal membranes 1e-050.00141 S000001508PAN3YKL025CverifiedEssential subunit of the Pan2p-Pan3p poly(A)-ribonucleasecomplex, which acts to control poly(A) taillength and regulate the stoichiometry andactivity of postreplication repair complexes 1e-050.00141 S000003388PTI1YGR156WverifiedPta1p Interacting protein 1e-050.00141 S000003566VPS53YJL029CverifiedComponent of the GARP (Golgi-associated retrograde protein)complex, Vps51p-Vps52p-Vps53p-Vps54p, which isrequired for the recycling of proteins fromendosomes to the late Golgi; required forvacuolar protein sorting 1e-050.00141 S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling 1e-050.00141 S000001756NAP1YKR048CverifiedProtein that interacts with mitotic cyclin Clb2p; required forthe regulation of microtubule dynamics duringmitosis; controls bud morphogenesis; involvedin the transport of H2A and H2B histones to thenucleus 1e-050.00141 S000002789YRA1YDR381WverifiedNuclear protein that binds to RNA and to Mex67p, required forexport of poly(A)+ mRNA from the nucleus;member of the REF (RNA and export factorbinding proteins) family; another familymember, Yra2p, can substitute for Yra1pfunction 1e-050.00141 S000002767VID21YDR359CverifiedComponent of the NuA4 histone acetyltransferase complex 1e-050.00141 S000006005BRO1YPL084WverifiedCytoplasmic class E vacuolar protein sorting (VPS) factor thatcoordinates deubiquitination in themultivesicular body (MVB) pathway by recruitingDoa4p to endosomes 1e-050.00141 S000005733RET1YOR207CverifiedSecond-largest subunit of RNA polymerase III, which isresponsible for the transcription of tRNA and5S RNA genes, and other low molecular weightRNAs 1e-050.00141 S000006067NOP53YPL146CverifiedNucleolar protein; involved in biogenesis of the 60S subunit ofthe ribosome; interacts with rRNA processingfactors Cbf5p and Nop2p; null mutant is viablebut growth is severely impaired 1e-050.00141 S000005166SSU72YNL222WverifiedTranscription/RNA-processing factor that associates with TFIIBand cleavage/polyadenylation factor Pta1p;exhibits phosphatase activity on serine-5 ofthe RNA polymerase II C-terminal domain;affects start site selection in vivo 1e-050.00141 S000005194RAD50YNL250WverifiedSubunit of MRX complex, with Mre11p and Xrs2p, involved inprocessing double-strand DNA breaks invegetative cells, initiation of meiotic DSBs,telomere maintenance, and nonhomologous endjoining 1e-050.00141 S000004837MRE11YMR224CverifiedSubunit of a complex with Rad50p and Xrs2p (RMX complex) thatfunctions in repair of DNA double-strand breaksand in telomere stability, exhibits nucleaseactivity that appears to be required for RMXfunction; widely conserved 1e-050.00141 S000004424IMD3YLR432WverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 1e-050.00141 S000004683CTF18YMR078CverifiedSubunit of a complex with Ctf8p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion; may have overlappingfunctions with Rad24p in the DNA damagereplication checkpoint 1e-050.00141 S000000286UBC4YBR082CverifiedUbiquitin-conjugating enzyme that mediates degradation ofshort-lived and abnormal proteins; interactswith E3-CaM in ubiquitinating calmodulin;interacts with many SCF ubiquitin proteinligases; component of the cellular stressresponse 1e-050.00141 S000004665RNA14YMR061WverifiedCleavage and polyadenylation factor I (CF I) component involvedin cleavage and polyadenylation of mRNA 3'ends; bridges interaction between Rna15p andHrp1p in the CF I complex 1e-050.00141 S000002603REF2YDR195WverifiedRNA-binding protein involved in the cleavage step of mRNA3'-end formation prior to polyadenylation, andin snoRNA maturation; part of holo-CPFsubcomplex APT, which associates with 3'-endsof snoRNA- and mRNA-encoding genes 1e-050.00141 S000004476TRM9YML014WverifiedtRNA methyltransferase, catalyzes the esterification ofmodified uridine nucleotides in tRNAs, creating5-methylcarbonylmethyluridine in tRNA(Arg3) and5-methylcarbonylmethyl-2-thiouridine intRNA(Glu); may have a role in stress response 1e-050.00141 S000003121PEX14YGL153WverifiedPeroxisomal membrane protein that is a central component of theperoxisomal protein import machinery, interactswith PTS1 (Pex5p) and PTS2 (Pex7p) peroxisomalmatrix protein signal recognition factors andmembrane receptor Pex13p 1e-050.00141 S000004138PEP3YLR148WverifiedVacuolar peripheral membrane protein that promotes vesiculardocking/fusion reactions in conjunction withSNARE proteins, required for vacuolarbiogenesis, forms complex with Pep5p thatmediates protein transport to the vacuole 1e-050.00141 S000002905ITR1YDR497CverifiedMyo-inositol transporter with strong similarity to the minormyo-inositol transporter Itr2p, member of thesugar transporter superfamily; expression isrepressed by inositol and choline via Opi1p andderepressed via Ino2p and Ino4p 1e-050.00141 S000002360TRM8YDL201WverifiedSubunit of a tRNA methyltransferase complex composed of Trm8pand Trm82p that catalyzes 7-methylguanosinemodification of tRNA 1e-050.00141 S000003651ASF1YJL115WverifiedNucleosome assembly factor, involved in chromatin assembly anddisassembly, anti-silencing protein that causesderepression of silent loci when overexpressed 1e-050.00141 S000000602RVS161YCR009CverifiedAmphiphysin-like lipid raft protein; subunit of a complex(Rvs161p-Rvs167p) that regulates polarizationof the actin cytoskeleton, endocytosis, cellpolarity, cell fusion and viability followingstarvation or osmotic stress 1e-050.00141 S000006082BEM4YPL161CverifiedProtein involved in establishment of cell polarity and budemergence; interacts with the Rho1p smallGTP-binding protein and with the Rho-typeGTPase Cdc42p; involved in maintenance ofproper telomere length 1e-050.00141 S000000935GLC7YER133WverifiedCatalytic subunit of type 1 serine/threonine proteinphosphatase, involved in many processesincluding glycogen metabolism, sporulation, andmitosis; interacts with multiple regulatorysubunits; predominantly isolated with Sds22p 1e-050.00141 S000004470SPT5YML010WverifiedProtein that forms a complex with Spt4p and mediates bothactivation and inhibition of transcriptionelongation; Spt4p-Spt5p complex also plays arole in pre-mRNA processing 1e-050.00141 S000003570HCA4YJL033WverifiedPutative nucleolar DEAD box RNA helicase; high-copy numbersuppression of a U14 snoRNA processing mutantsuggests an involvement in 18S rRNA synthesis 1e-050.00141 S000001886SMC1YFL008WverifiedSubunit of the multiprotein cohesin complex, essential proteininvolved in chromosome segregation and indouble-strand DNA break repair; SMC chromosomalATPase family member, binds DNA with apreference for DNA with secondary structure 1e-050.00141 S000004494RAD52YML032CverifiedProtein that stimulates strand exchange by facilitating Rad51pbinding to single-stranded DNA; annealscomplementary single-stranded DNA; involved inthe repair of double-strand breaks in DNAduring vegetative growth and meiosis 1e-050.00141 S000005606DIA2YOR080WverifiedOrigin-binding F-box protein that forms an SCF ubiquitin ligasecomplex with Skp1p and Cdc53p; plays a role inDNA replication, involved in invasive andpseudohyphal growth 1e-050.00141 S000001906UBP6YFR010WverifiedUbiquitin-specific protease situated in the base subcomplex ofthe 26S proteasome, releases free ubiquitinfrom branched polyubiquitin chains; deletioncauses hypersensitivity to cycloheximide andother toxic compounds 1e-050.00141 S000001025RPL8AYHL033CverifiedRibosomal protein L4 of the large (60S) ribosomal subunit,nearly identical to Rpl8Bp and has similarityto rat L7a ribosomal protein; mutation resultsin decreased amounts of free 60S subunits 1e-050.00141 S000002718SUM1YDR310CverifiedTranscriptional repressor required for mitotic repression ofmiddle sporulation-specific genes; involved intelomere maintenance, regulated by thepachytene checkpoint 1e-050.00141 S000004732STO1YMR125WverifiedLarge subunit of the nuclear mRNA cap-binding protein complex,interacts with Npl3p to carry nuclear poly(A)+mRNA to cytoplasm; also involved in nuclearmRNA degradation and telomere maintenance;orthologous to mammalian CBP80 1e-050.00141 S000004851DFG5YMR238WverifiedPutative mannosidase, essential glycosylphosphatidylinositol(GPI)-anchored membrane protein required forcell wall biogenesis in bud formation, involvedin filamentous growth, homologous to Dcw1p 1e-050.00136 S000003617ARP4YJL081CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes 1e-050.00136 S000028769YGL006W-AUncharacterizedIdentified by SAGE 1e-050.00136 S000003226MNT2YGL257CverifiedMannosyltransferase involved in adding the 4th and 5th mannoseresidues of O-linked glycans 1e-050.00136 S000000333OPY1YBR129CverifiedProtein of unknown function, overproduction blocks cell cyclearrest in the presence of mating pheromone; theauthentic, non-tagged protein is detected inhighly purified mitochondria in high-throughputstudies 1e-050.00136 S000003806SSC1YJR045CverifiedMitochondrial matrix ATPase that is a subunit of thepresequence translocase-associated proteinimport motor (PAM); involved in proteintranslocation into the matrix and proteinfolding; member of the heat shock protein 70(HSP70) family 1e-050.00136 S000004238RCK2YLR248WverifiedProtein kinase involved in the response to oxidative andosmotic stress; identified as suppressor of S.pombe cell cycle checkpoint mutations 1e-050.00136 S000006253ATG11YPR049CverifiedPeripheral membrane protein required for delivery ofaminopeptidase I (Lap4p) to the vacuole in thecytoplasm-to-vacuole targeting pathway; alsorequired for peroxisomal degradation(pexophagy) 1e-050.00136 S000005417GPM3YOL056WverifiedHomolog of Gpm1p phosphoglycerate mutase, which converts3-phosphoglycerate to 2-phosphoglycerate inglycolysis; may be non-functional derivative ofa gene duplication event 1e-050.00136 S000004848RNA1YMR235CverifiedGTPase activating protein (GAP) for Gsp1p, involved in nucleartransport 1e-050.00136 S000005028END3YNL084CverifiedEH domain-containing protein involved in endocytosis, actincytoskeletal organization and cell wallmorphogenesis; forms a complex with Sla1p andPan1p 1e-050.00136 S000028525YLR307C-AUncharacterizedPutative protein of unknown function 1e-050.00136 S000004794RGM1YMR182CverifiedPutative transcriptional repressor with proline-rich zincfingers; overproduction impairs cell growth 1e-050.00136 S000006398OPT2YPR194CverifiedOligopeptide transporter; member of the OPT family, withpotential orthologs in S. pombe and C. albicans 1e-050.00136 S000001204YAP1801YHR161CverifiedProtein involved in clathrin cage assembly; binds Pan1p andclathrin; homologous to Yap1802p, member of theAP180 protein family 1e-050.00136 S000000639YCR043CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene 1e-050.00136 S000004873TIF11YMR260CverifiedTranslation initiation factor eIF1A, essential protein thatforms a complex with Sui1p (eIF1) and the 40Sribosomal subunit and scans for the startcodon; C-terminus associates with Fun12p(eIF5B); N terminus interacts with eIF2 andeIF3 1e-050.00136 S000001570CYT2YKL087CverifiedCytochrome c1 heme lyase, involved in maturation of cytochromec1, which is a subunit of the mitochondrialubiquinol-cytochrome-c reductase; links hemecovalently to apocytochrome c1 1e-050.00136 S000005491YOL131WUncharacterizedPutative protein of unknown function 1e-050.00136 S000005021APJ1YNL077WverifiedPutative chaperone of the HSP40 (DNAJ) family; overexpressioninterferes with propagation of the [Psi+]prion; the authentic, non-tagged protein isdetected in highly purified mitochondria inhigh-throughput studies 1e-050.00136 S000001360FMC1YIL098CverifiedMitochondrial matrix protein, required for assembly orstability at high temperature of the F1 sectorof mitochondrial F1F0 ATP synthase; null mutanttemperature sensitive growth on glycerol issuppressed by multicopy expression of Odc1p 1e-050.00136 S000000971RPH1YER169WverifiedTranscriptional repressor of PHR1, which is a photolyaseinduced by DNA damage; binds to AG(4) (C(4)T)sequence upstream of PHR1; Rph1pphosphorylation during DNA damage is undercontrol of the MEC1-RAD53 pathway 1e-050.00136 S000005254ZIM17YNL310CverifiedHeat shock protein with a zinc finger motif; essential forprotein import into mitochondria; may act withPam18p to facilitate recognition and folding ofimported proteins by Ssc1p (mtHSP70) in themitochondrial matrix 1e-050.00136 S000004898NGL2YMR285CverifiedProtein involved in 5.8S rRNA processing; Ccr4p-like RNaserequired for correct 3'-end formation of 5.8SrRNA at site E; similar to Ngl1p and Ngl3p 1e-050.00136 S000001729ALY1YKR021WuncharacterizedPutative protein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to the cytoplasm 1e-050.00136 S000002637IVY1YDR229WverifiedPhospholipid-binding protein that interacts with both Ypt7p andVps33p, may partially counteract the action ofVps33p and vice versa, localizes to the rim ofthe vacuole as cells approach stationary phase 1e-050.00136 S000003631BCK1YJL095WverifiedMitogen-activated protein (MAP) kinase kinase kinase acting inthe protein kinase C signaling pathway, whichcontrols cell integrity; upon activation byPkc1p phosphorylates downstream kinases Mkk1pand Mkk2p 1e-050.00136 S000004961PUB1YNL016WverifiedPoly(A)+ RNA-binding protein, abundant mRNP-component proteinthat binds mRNA and is required for stabilityof a number of mRNAs; not reported to associatewith polyribosomes 1e-050.00136 S000003597NUP82YJL061WverifiedSubunit of the nuclear pore complex (NPC), forms a subcomplexwith Nup159p and Nsp1p, interacts with Nup116pand is required for proper localization ofNup116p in the NPC 1e-050.00136 S000000913SWI4YER111CverifiedDNA binding component of the SBF complex (Swi4p-Swi6p), atranscriptional activator that in concert withMBF (Mbp1-Swi6p) regulates late G1-specifictranscription of targets including cyclins andgenes required for DNA synthesis and repair 1e-050.00136 S000004375SMC6YLR383WverifiedProtein involved in structural maintenance of chromosomes;essential subunit of Mms21-Smc5-Smc6 complex;required for growth, DNA repair,interchromosomal and sister chromatidrecombination; homologous to S. pombe rad18 1e-050.00136 S000006337SPN1YPR133CverifiedProtein that interacts with Spt6p and copurifies with Spt5p andRNA polymerase II, probable transcriptionalelongation factor; metazoan homologs contain anacidic N terminus; mutations in the gene conferan Spt- phenotype 1e-050.00136 S000001908YFR012WUncharacterizedHypothetical protein 1e-050.00136 S000005238RIM21YNL294CverifiedComponent of the RIM101 pathway, has a role in cell wallconstruction and alkaline pH response; hassimilarity to A. nidulans PalH 1e-050.00136 S000002528DPB4YDR121WverifiedShared subunit of DNA polymerase epsilon and of ISW2/yCHRACchromatin accessibility complex; involved inboth chromosomal DNA replication and ininheritance of telomeric silencing 1e-050.00136 S000006069PPT2YPL148CverifiedPhosphopantetheine:protein transferase (PPTase), activatesmitochondrial acyl carrier protein (Acp1p) byphosphopantetheinylation 1e-050.00136 S000004535DAK1YML070WverifiedDihydroxyacetone kinase, required for detoxification ofdihydroxyacetone (DHA); involved in stressadaptation 1e-050.00136 S000006305SNT309YPR101WverifiedComponent of NineTeen complex (NTC) containing Prp19p involvedin mRNA splicing, interacts physically andgenetically with Prp19p 1e-050.00136 S000006363KRE6YPR159WverifiedProtein required for beta-1,6 glucan biosynthesis; putativebeta-glucan synthase; appears functionallyredundant with Skn1p 1e-050.00136 S000002740IRC3YDR332WuncharacterizedHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 1e-050.00136 S000006406YPR202WUncharacterizedPutative protein of unknown function with similarity to telomere-encoded helicases; YPR202W is not an essential gene; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo 1e-050.00136 S000004845FUS2YMR232WverifiedCytoplasmic protein localized to the shmoo tip; required forthe alignment of parental nuclei before nuclearfusion during mating 1e-050.00136 S000003527COS6YGR295CverifiedProtein of unknown function, member of the DUP380 subfamily ofconserved, often subtelomerically-encodedproteins 1e-050.00136 S000005702HEM15YOR176WverifiedFerrochelatase, a mitochondrial inner membrane protein,catalyzes the insertion of ferrous iron intoprotoporphyrin IX, the eighth and final step inthe heme biosynthetic pathway 1e-050.00136 S000000110RRN6YBL014CverifiedProtein involved in the transcription of 35S rRNA genes by RNApolymerase I; component of the core factor (CF)complex also composed of Rrn11p, Rrn7p andTATA-binding protein 1e-050.00136 S000004044OSW2YLR054CuncharacterizedProtein of unknown function proposed to be involved in theassembly of the spore wall 1e-050.00136 S000000307SIF2YBR103WverifiedWD40 repeat-containing subunit of the Set3C histone deacetylasecomplex, which represses early/middlesporulation genes; antagonizes telomericsilencing; binds specifically to the Sir4pN-terminus 1e-050.00136 S000004037FRE8YLR047CverifiedProtein with sequence similarity to iron/copper reductases,involved in iron homeostasis; deletion mutanthas iron deficiency/accumulation growthdefects; expression increased in the absence ofcopper-responsive transcription factor Mac1p 1e-050.00136 S000004712YKU80YMR106CverifiedSubunit of the telomeric Ku complex (Yku70p-Yku80p), involvedin telomere length maintenance, structure andtelomere position effect; relocates to sites ofdouble-strand cleavage to promote nonhomologousend joining during DSB repair 1e-050.00136 S000004422SEN1YLR430WverifiedPutative helicase required for RNA polymerase II transcriptiontermination and processing of RNAs; homolog ofSenataxin which causes Ataxia-OculomotorApraxia 2 and a dominant form of amyotrophiclateral sclerosis 1e-050.00136 S000003304UPF3YGR072WverifiedComponent of the nonsense-mediated mRNA decay (NMD) pathway,along with Nam7p and Nmd2p; involved in decayof mRNA containing nonsense codons; involved intelomere maintenance 1e-050.00136 S000001057MIP6YHR015WverifiedPutative RNA-binding protein, interacts with Mex67p, which is acomponent of the nuclear pore involved innuclear mRNA export 1e-050.00136 S000002643PRP42YDR235WverifiedU1 snRNP protein involved in splicing, required for U1 snRNPbiogenesis; contains multipletetriatricopeptide repeats 1e-050.00136 S000002279YDL121CUncharacterizedHypothetical protein 1e-050.00136 S000005577YOR051CUncharacterizedNuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts 1e-050.00136 S000000896PUP3YER094CverifiedBeta subunit of the 20S proteasome involved inubiquitin-dependent catabolism; human homologis subunit C10 1e-050.00136 S000003294COX18YGR062CverifiedMitochondrial inner membrane protein, required for export ofthe Cox2p C terminus from the mitochondrialmatrix to the intermembrane space during itsassembly into cytochrome c oxidase; similar toOxa2p of N. crassa 1e-050.00136 S000003979YLL056CUncharacterizedPutative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene 1e-050.00136 S000003209DOC1YGL240WverifiedProcessivity factor required for the ubiquitination activity ofthe anaphase promoting complex (APC), mediatesthe activity of the APC by contributing tosubstrate recognition; involved in cyclinproteolysis 1e-050.00136 S000001719YKR011CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus 1e-050.00136 S000000904RPS8BYER102WverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps8Ap and has similarity to ratS8 ribosomal protein 1e-050.00136 S000000007SPO7YAL009WverifiedIntegral nuclear/ER membrane protein of unknown function,required for normal nuclear envelope morphologyand sporulation 1e-050.00136 S000000523LEU2YCL018WverifiedBeta-isopropylmalate dehydrogenase, catalyzes the third step inthe leucine biosynthesis pathway 1e-050.00136 S000002187ARP2YDL029WverifiedEssential component of the Arp2/3 complex, which is a highlyconserved actin nucleation center required forthe motility and integrity of actin patches;involved in endocytosis and membrane growth andpolarity 1e-050.00136 S000003500HUA1YGR268CuncharacterizedCytoplasmic protein containing a zinc finger domain withsequence similarity to that of Type IJ-proteins; computational analysis oflarge-scale protein-protein interaction datasuggests a possible role in actin patchassembly 1e-050.00136 S000005264YNL320WUncharacterizedHypothetical protein 1e-050.00136 S000001677MST1YKL194CverifiedMitochondrial threonyl-tRNA synthetase 1e-050.00136 S000006117OXR1YPL196WverifiedProtein of unknown function required for normal levels ofresistance to oxidative damage, null mutantsare sensitive to hydrogen peroxide; member of aconserved family of proteins found ineukaryotes but not in prokaryotes 1e-050.00136 S000002843PPM1YDR435CverifiedCarboxyl methyl transferase, methylates the C terminus of theprotein phosphatase 2A catalytic subunit(Pph21p or Pph22p), which is important forcomplex formation with regulatory subunits 1e-050.00136 S000003154TPN1YGL186CverifiedPlasma membrane pyridoxine (vitamin B6) transporter; member ofthe purine-cytosine permease subfamily withinthe major facilitator superfamily; protonsymporter with similarity to Fcy21p, Fcy2p, andFcy22p 1e-050.00136 S000002625RAD9YDR217CverifiedDNA damage-dependent checkpoint protein, required forcell-cycle arrest in G1/S, intra-S, and G2/M;transmits checkpoint signal by activatingRad53p and Chk1p; hyperphosphorylated by Mec1pand Tel1p; potential Cdc28p substrate 1e-050.00136 S000003985MHT1YLL062CverifiedS-methylmethionine-homocysteine methyltransferase, functionsalong with Sam4p in the conversion ofS-adenosylmethionine (AdoMet) to methionine tocontrol the methionine/AdoMet ratio 1e-050.00136 S000005975LEE1YPL054WverifiedZinc-finger protein of unknown function 1e-050.00136 S000003314TOM20YGR082WverifiedComponent of the TOM (translocase of outer membrane) complexresponsible for recognition and initial importsteps for all mitochondrially directedproteins; acts as a receptor for incomingprecursor proteins 1e-050.00136 S000005271EGT2YNL327WverifiedGlycosylphosphatidylinositol (GPI)-anchored cell wallendoglucanase required for proper cellseparation after cytokinesis, expression isactivated by Swi5p and tightly regulated in acell cycle-dependent manner 1e-050.00136 S000001828YFL066CUncharacterizedHelicase-like protein encoded within the telomeric Y' element 1e-050.00136 S000001261YHR218WUncharacterizedHelicase-like protein encoded within the telomeric Y' element 1e-050.00136 S000000308YMC2YBR104WverifiedPutative mitochondrial inner membrane transporter, member ofthe mitochondrial carrier (MCF) family 1e-050.00136 S000004754TIF34YMR146CverifiedSubunit of the core complex of translation initiation factor3(eIF3), which is essential for translation 1e-050.00136 S000004978YNL033WUncharacterizedPutative protein of unknown function 1e-050.00136 S000028597YBL071C-BUncharacterizedPutative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 1e-050.00136 S000004603CDC5YMR001CverifiedPolo-like kinase with similarity to Xenopus Plx1 and S. pombePlo1p; found at bud neck, nucleus and SPBs; hasmultiple functions in mitosis and cytokinesisthrough phosphorylation of substrates; may be aCdc28p substrate 1e-050.00136 S000005933RRP12YPL012WverifiedProtein required for export of the ribosomal subunits;associates with the RNA components of thepre-ribosomes; contains HEAT-repeats 1e-050.00136 S000005421MAM3YOL060CverifiedProtein required for normal mitochondrial morphology, hassimilarity to hemolysins 1e-050.00136 S000006180APM1YPL259CverifiedMu1-like medium subunit of the clathrin-associated proteincomplex (AP-1); binds clathrin; involved inclathrin-dependent Golgi protein sorting 1e-050.00136 S000004487YML6YML025CverifiedMitochondrial ribosomal protein of the large subunit, hassimilarity to E. coli L4 ribosomal protein andhuman mitoribosomal MRP-L4 protein; essentialfor viability, unlike most other mitoribosomalproteins 1e-050.00136 S000002389PTP1YDL230WverifiedPhosphotyrosine-specific protein phosphatase thatdephosphorylates a broad range of substrates invivo, including Fpr3p; localized to thecytoplasm and the mitochondria 1e-050.00136 S000001104RPP1YHR062CverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends 1e-050.00136 S000004643YET2YMR040WverifiedProtein of unknown function that may interact with ribosomes,based on co-purification experiments; homologof human BAP31 protein 1e-050.00136 S000002953YRF1-1YDR545WverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p 1e-050.00136 S000001848FMP32YFL046WuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 1e-050.00136 S000005923SNF8YPL002CverifiedComponent of the ESCRT-II complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; appears to be functionallyrelated to SNF7; involved in glucosederepression 1e-050.00136 S000028662YJL077W-BUncharacterizedPutative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 1e-050.00136 S000003229YGL260WUncharacterizedPutative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium 1e-050.00136 S000007548YCL026C-BUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 1e-050.00136 S000004018ADE16YLR028CverifiedEnzyme of 'de novo' purine biosynthesis containing both5-aminoimidazole-4-carboxamide ribonucleotidetransformylase and inosine monophosphatecyclohydrolase activities, isozyme of Ade17p;ade16 ade17 mutants require adenine andhistidine 1e-050.00136 S000001304PKP1YIL042CverifiedMitochondrial kinase, phosphorylates pyruvate dehydrogenasealpha subunit Pda1p 1e-050.00136 S000004110YPS1YLR120CverifiedAspartic protease, attached to the plasma membrane via aglycosylphosphatidylinositol (GPI) anchor 1e-050.00136 S000000812YER010CVerifiedProtein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction 1e-050.00136 S000002935RBA50YDR527WverifiedProtein involved in transcription; interacts with RNApolymerase II subunits Rpb2p, Rpb3, and Rpb11p;has similarity to human RPAP1 1e-050.00136 S000003026RAD6YGL058WverifiedUbiquitin-conjugating enzyme (E2), involved in postreplicationrepair (with Rad18p), sporulation, telomeresilencing, and ubiquitin-mediated N-end ruleprotein degradation (with Ubr1p) 1e-050.00136 S000004284GSP1YLR293CverifiedGTP binding protein (mammalian Ranp homolog) involved in themaintenance of nuclear organization, RNAprocessing and transport; regulated by Prp20p,Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p andKap95p; yeast Gsp2p homolog 1e-050.00136 S000004069SIC1YLR079WverifiedInhibitor of Cdc28-Clb kinase complexes that controls G1/Sphase transition, preventing premature S phaseand ensuring genomic integrity; phosphorylationtargets Sic1p for SCF(CDC4)-dependent turnover;functional homolog of mammalian Kip1 1e-050.00136 S000002881PRP3YDR473CverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 1e-050.00136 S000004296STT4YLR305CverifiedPhosphatidylinositol-4-kinase that functions in the Pkc1pprotein kinase pathway; required for normalvacuole morphology, cell wall integrity, andactin cytoskeleton organization 1e-050.00136 S000005090YNL146WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene 1e-050.00136 S000003033ALG2YGL065CverifiedPresumed early mannosyltransferase involved in the N-linkedglycosylation pathway; alg2 mutants exhibittemperature-sensitive growth and abnormalaccumulation of the lipid-linkedoligosaccharide Man2GlcNAc2-PP-Dol 1e-050.00136 S000000048OAF1YAL051WverifiedOleate-activated transcription factor, acts alone and as aheterodimer with Pip2p; activates genesinvolved in beta-oxidation of fatty acids andperoxisome organization and biogenesis 1e-050.00136 S000005545YOR019WUncharacterizedHypothetical protein 1e-050.00136 S000003012RNA15YGL044CverifiedCleavage and polyadenylation factor I (CF I) component involvedin cleavage and polyadenylation of mRNA 3'ends; interacts with the A-rich polyadenylationsignal in complex with Rna14p and Hrp1p 1e-050.00136 S000003288RSC1YGR056WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; containstwo essential bromodomains, a bromo-adjacenthomology (BAH) domain, and an AT hook 1e-050.00136 S000002327SFA1YDL168WverifiedBifunctional enzyme containing both alcohol dehydrogenase andglutathione-dependent formaldehydedehydrogenase activities, functions informaldehyde detoxification and formation oflong chain and complex alcohols, regulated byHog1p-Sko1p 1e-050.00136 S000001696DOA1YKL213CverifiedWD repeat protein required for ubiquitin-mediated proteindegradation, forms complex with Cdc48p, plays arole in controlling cellular ubiquitinconcentration; also promotes efficient NHEJ inpostdiauxic/stationary phase 1e-050.00136 S000001602VPH2YKL119CverifiedIntegral membrane protein required for vacuolar H+-ATPase(V-ATPase) function, although not an actualcomponent of the V-ATPase complex; functions inthe assembly of the V-ATPase; localized to theendoplasmic reticulum (ER) 1e-050.00136 S000003161YGL193CUncharacterizedHaploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold 1e-050.00136 S000005822YOR296WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene 1e-050.00136 S000006120YPL199CUncharacterizedHypothetical protein 1e-050.00136 S000000984FMP10YER182WuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 1e-050.00136 S000004077CSF1YLR087CverifiedProtein required for fermentation at low temperature; theauthentic, non-tagged protein is detected inhighly purified mitochondria in high-throughputstudies 1e-050.00136 S000000787CIN8YEL061CverifiedKinesin motor protein involved in mitotic spindle assembly andchromosome segregation 1e-050.00136 S000004011IRC25YLR021WuncharacterizedPutative protein of unknown function; mutant accumulatesunusually high amounts of dityrosine in thesoluble fraction though spores appearwild-type; YLR021W is not an essential gene;null mutant displays increased levels ofspontaneous Rad52 foci 1e-050.00136 S000005384YOL024WUncharacterizedHypothetical protein 1e-050.00136 S000000237EDS1YBR033WuncharacterizedNon-essential protein of unknown function 1e-050.00136 S000005184NAR1YNL240CverifiedNuclear architecture related protein; component of thecytosolic iron-sulfur (FeS) protein assemblymachinery, required for maturation of cytosolicand nuclear FeS proteins; homologous to humanNarf 1e-050.00136 S000006378YPR174CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate 1e-050.00136 S000002889PHO8YDR481CverifiedRepressible alkaline phosphatase, a glycoprotein localized tothe vacuole; regulated by levels of inorganicphosphate and by a system consisting of Pho4p,Pho9p, Pho80p, Pho81p and Pho85p;dephosphorylates phosphotyrosyl peptides 1e-050.00136 S000002161MCD1YDL003WverifiedEssential protein required for sister chromatid cohesion inmitosis and meiosis; subunit of the cohesincomplex; expression is cell cycle regulated andpeaks in S phase 1e-050.00136 S000001702COS9YKL219WverifiedProtein of unknown function, member of the DUP380 subfamily ofconserved, often subtelomerically-encodedproteins 1e-050.00136 S000003625SIP4YJL089WverifiedC6 zinc cluster transcriptional activator that binds to thecarbon source-responsive element (CSRE) ofgluconeogenic genes; involved in the positiveregulation of gluconeogenesis; regulated bySnf1p protein kinase; localized to the nucleus 1e-050.00136 S000004694VBA1YMR088CverifiedPermease of basic amino acids in the vacuolar membrane 1e-050.00136 S000001789RPF2YKR081CverifiedEssential protein involved in the processing of pre-rRNA andthe assembly of the 60S ribosomal subunit;interacts with ribosomal protein L11; localizespredominantly to the nucleolus; constituent of66S pre-ribosomal particles 1e-050.00136 S000000890DOT6YER088CverifiedProtein of unknown function, involved in telomeric genesilencing and filamentation 1e-050.00136 S000003581YJL045WUncharacterizedMinor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner 1e-050.00136 S000005201SIP3YNL257CverifiedProtein that activates transcription through interaction withDNA-bound Snf1p, C-terminal region has aputative leucine zipper motif; potential Cdc28psubstrate 1e-050.00136 S000001803MLP1YKR095WverifiedMyosin-like protein associated with the nuclear envelope,connects the nuclear pore complex with thenuclear interior; involved with Tel1p intelomere length control; involved with Pml1pand Pml39p in nuclear retention of unsplicedmRNAs 1e-050.00136 S000000772GLY1YEL046CverifiedThreonine aldolase, catalyzes the cleavage of L-allo-threonineand L-threonine to glycine; involved in glycinebiosynthesis 1e-050.00136 S000002429CIS1YDR022CverifiedProtein of unknown function that may be involved in microtubuleorganization; high-copy suppressor of CIK1deletion 1e-050.00136 S000004388VPS33YLR396CverifiedATP-binding protein that is a subunit of the homotypic vacuolefusion and vacuole protein sorting (HOPS)complex; essential for membrane docking andfusion at both the Golgi-to-endosome andendosome-to-vacuole stages of protein transport 1e-050.00136 S000005626CRC1YOR100CverifiedMitochondrial inner membrane carnitine transporter, requiredfor carnitine-dependent transport of acetyl-CoAfrom peroxisomes to mitochondria during fattyacid beta-oxidation 1e-050.00136 S000000283RPG1YBR079CverifiedSubunit of the core complex of translation initiation factor3(eIF3), essential for translation; part of asubcomplex (Prt1p-Rpg1p-Nip1p) that stimulatesbinding of mRNA and tRNA(i)Met to ribosomes 1e-050.00136 S000006052RPL5YPL131WverifiedProtein component of the large (60S) ribosomal subunit withsimilarity to E. coli L18 and rat L5 ribosomalproteins; binds 5S rRNA and is required for 60Ssubunit assembly 1e-050.00136 S000004157RPS31YLR167WverifiedFusion protein that is cleaved to yield a ribosomal protein ofthe small (40S) subunit and ubiquitin;ubiquitin may facilitate assembly of theribosomal protein into ribosomes; interactsgenetically with translation factor eIF2B 1e-050.00136 S000003470KEL2YGR238CverifiedProtein that functions in a complex with Kel1p to negativelyregulate mitotic exit, interacts with Tem1p andLte1p; localizes to regions of polarizedgrowth; potential Cdc28p substrate 1e-050.00136 S000005029MKT1YNL085WverifiedProtein that forms a complex with Pbp1p that may mediateposttranscriptional regulation of HOendonuclease; involved in propagation of M2dsRNA satellite of L-A virus 1e-050.00136 S000006138BMS1YPL217CverifiedEssential conserved nucleolar GTP-binding protein required forsynthesis of 40S ribosomal subunits and forprocessing of the 35S pre-rRNA at sites A0, A1,and A2; interacts with Rcl1p, has similarity toTsr1p 1e-050.00136 S000003187MDM34YGL219CverifiedMitochondrial outer membrane protein, required for normalmitochondrial morphology and inheritance;localizes to dots on the mitochondrial surfacenear mtDNA nucleoids; interacts geneticallywith MDM31 and MDM32 1e-050.00136 S000003232COS12YGL263WverifiedProtein of unknown function, member of the DUP380 subfamily ofconserved, often subtelomerically-encodedproteins 1e-050.00136 S000005728HIS3YOR202WverifiedImidazoleglycerol-phosphate dehydratase, catalyzes the sixthstep in histidine biosynthesis; mutations causehistidine auxotrophy and sensitivity to Cu, Co,and Ni salts; transcription is regulated bygeneral amino acid control via Gcn4p 1e-050.00136 S000002690YDR282CUncharacterizedHypothetical protein 1e-050.00136 S000007267ATP8Q0080verifiedSubunit 8 of the F0 sector of mitochondrial inner membraneF1-F0 ATP synthase, encoded on themitochondrial genome 1e-050.00136 S000003130SUT1YGL162WverifiedTranscription factor of the Zn[II]2Cys6 family involved insterol uptake; involved in induction of hypoxicgene expression 1e-050.00136 S000028707YOL019W-AUncharacterizedIdentified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 1e-050.00136 S000005175PDR16YNL231CverifiedPhosphatidylinositol transfer protein (PITP) controlled by themultiple drug resistance regulator Pdr1p,localizes to lipid particles and microsomes,controls levels of various lipids, may regulatelipid synthesis, homologous to Pdr17p 1e-050.00136 S000005957PMA2YPL036WverifiedPlasma membrane H+-ATPase, isoform of Pma1p, involved inpumping protons out of the cell; regulator ofcytoplasmic pH and plasma membrane potential 1e-050.00136 S000002991PIB2YGL023CverifiedProtein binding phosphatidylinositol 3-phosphate, involved intelomere-proximal repression of geneexpression; similar to Fab1 and Vps27 1e-050.00136 S000005972ARL3YPL051WverifiedGTPase of the Ras superfamily required to recruit Arl1p to theGolgi; similar to ADP-ribosylation factor 1e-050.00136 S000004597MSC1YML128CverifiedProtein of unknown function; mutant is defective in directingmeiotic recombination events to homologouschromatids; the authentic, non-tagged proteinis detected in highly purified mitochondria inhigh-throughput studies 1e-050.00136 S000002140YAL064C-AUncharacterizedHypothetical protein 1e-050.00136 S000005292NRM1YNR009WverifiedTranscriptional co-repressor of MBF (MCB bindingfactor)-regulated gene expression; Nrm1passociates stably with promoters via MBF torepress transcription upon exit from G1 phase 1e-050.00136 S000002276YDL118WUncharacterizedNon-essential protein of unconfirmed function; mutants are defective in telomere maintenance, and are synthetically sick or lethal with alpha-synuclein 1e-050.00136 S000001156BZZ1YHR114WverifiedSH3 domain protein implicated in the regulation of actinpolymerization, able to recruit actinpolymerization machinery through its SH3domains, colocalizes with cortical actinpatches and Las17p, interacts with type Imyosins 1e-050.00136 S000003193VRG4YGL225WverifiedGolgi GDP-mannose transporter; regulates Golgi function andglycosylation in Golgi 1e-050.00136 S000005485TRM13YOL125WuncharacterizedHypothetical protein 1e-050.00136 S000006380BET2YPR176CverifiedBeta subunit of Type II geranylgeranyltransferase required forvesicular transport between the endoplasmicreticulum and the Golgi; provides a membraneattachment moiety to Rab-like proteins Ypt1pand Sec4p 1e-050.00136 S000000138FUI1YBL042CverifiedHigh affinity uridine permease, localized to the plasmamembrane; not involved in uracil transport 1e-050.00136 S000002731PEP7YDR323CverifiedMultivalent adaptor protein that facilitates vesicle-mediatedvacuolar protein sorting by ensuringhigh-fidelity vesicle docking and fusion, whichare essential for targeting of vesicles to theendosome; required for vacuole inheritance 1e-050.00136 S000005572DBP5YOR046CverifiedCytoplasmic ATP-dependent RNA helicase of the DEAD-box familyinvolved in mRNA export from the nucleus 1e-050.00136 S000004237IRC20YLR247CuncharacterizedPutative helicase; localized to mitochondria and the nucleus;YLR247C is not an essential gene; null mutantdisplays increased levels of spontaneous Rad52foci 1e-050.00136 S000006255MAK3YPR051WverifiedCatalytic subunit of N-terminal acetyltransferase of the NatCtype; required for replication of dsRNA virus 1e-050.00136 S000003704SET2YJL168CverifiedHistone methyltransferase with a role in transcriptionalelongation, methylates a lysine residue ofhistone H3; associates with the C-terminaldomain of Rpo21p; histone methylation activityis regulated by phosphorylation status ofRpo21p 1e-050.00136 S000002826RPL12BYDR418WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl12Ap; rpl12a rpl12b doublemutant exhibits slow growth and slowtranslation; has similarity to E. coli L11 andrat L12 ribosomal proteins 1e-050.00136 S000004016SED5YLR026Cverifiedcis-Golgi t-SNARE syntaxin required for vesicular transportbetween the ER and the Golgi complex, binds atleast 9 SNARE proteins 1e-050.00136 S000006228YME1YPR024WverifiedSubunit, with Mgr1p, of the mitochondrial inner membrane i-AAAprotease complex, which is responsible fordegradation of unfolded or misfoldedmitochondrial gene products; mutation causes anelevated rate of mitochondrial turnover 1e-050.00136 S000003479CPD1YGR247WverifiedCyclic nucleotide phosphodiesterase, hydrolyzes ADP-ribose 1'',2''-cyclic phosphate to ADP-ribose1''-phosphate; no detectable phenotype isconferred by null mutation or by overexpression 1e-050.00136 S000004830GUA1YMR217WverifiedGMP synthase, an enzyme that catalyzes the second step in thebiosynthesis of GMP from inosine 5'-phosphate(IMP); transcription is not subject toregulation by guanine but is negativelyregulated by nutrient starvation 1e-050.00136 S000005997GPI2YPL076WverifiedProtein involved in the synthesis of N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI), the firstintermediate in the synthesis ofglycosylphosphatidylinositol (GPI) anchors;homologous to the human PIG-C protein 1e-050.00136 S000004131RRN5YLR141WverifiedProtein involved in transcription of rDNA by RNA polymerase I;transcription factor, member of UAF (upstreamactivation factor) family along with Rrn9p andRrn10p 1e-050.00136 S000003715PFD1YJL179WverifiedSubunit of heterohexameric prefoldin, which binds cytosolicchaperonin and transfers target proteins to it;involved in the biogenesis of actin and ofalpha- and gamma-tubulin 1e-050.00136 S000002529KIN1YDR122WverifiedSerine/threonine protein kinase involved in regulation ofexocytosis; localizes to the cytoplasmic faceof the plasma membrane; closely related toKin2p 1e-050.00136 S000003487COQ6YGR255CverifiedPutative flavin-dependent monooxygenase, involved in ubiquinone(Coenzyme Q) biosynthesis; located on thematrix side of the mitochondrial inner membrane 1e-050.00136 S000003354YGR122WUncharacterizedPutative protein of unknown function; deletion mutants do not properly process Rim101p and have decreased resistance to rapamycin; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 1e-050.00136 S000002697RTT103YDR289CverifiedProtein that interacts with exonuclease Rat1p and Rai1p andplays a role in transcription termination byRNA polymerase II, has an RPR domain(carboxy-terminal domain interacting domain);also involved in regulation of Ty1transposition 1e-050.00136 S000004433RPS1AYLR441CverifiedRibosomal protein 10 (rp10) of the small (40S) subunit; nearlyidentical to Rps1Bp and has similarity to ratS3a ribosomal protein 1e-050.00136 S000003169MCM6YGL201CverifiedProtein involved in DNA replication; component of the Mcm2-7hexameric complex that binds chromatin as apart of the pre-replicative complex 1e-050.00136 S000004193MSS51YLR203CverifiedNuclear encoded protein required for translation of COX1 mRNA;binds to Cox1 protein 1e-050.00136 S000003699YJL163CUncharacterizedHypothetical protein 1e-050.00136 S000005980GRX5YPL059WverifiedHydroperoxide and superoxide-radical responsiveglutathione-dependent oxidoreductase;mitochondrial matrix protein involved in thesynthesis/assembly of iron-sulfur centers;monothiol glutaredoxin subfamily member alongwith Grx3p and Grx4p 1e-050.00136 S000003415QCR9YGR183CverifiedSubunit 9 of the ubiquinol cytochrome-c reductase complex,which is a component of the mitochondrial innermembrane electron transport chain; required forelectron transfer at the ubiquinol oxidase siteof the complex 1e-050.00136 S000000452HIS7YBR248CverifiedImidazole glycerol phosphate synthase (glutamineamidotransferase:cyclase), catalyzes the fifthand sixth steps of histidine biosynthesis andalso produces 5-aminoimidazole-4-carboxamideribotide (AICAR), a purine precursor 1e-050.00136 S000028562YLR154C-HUncharacterizedPutative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-2 1e-050.00136 S000004087HRT3YLR097CuncharacterizedPutative nuclear ubiquitin ligase, based on computationalanalysis of large-scale protein-proteininteraction data; has similarity to F-boxproteins; identified in association withCdc53p, Skp1p and Ubi4 in large-scale studies 1e-050.00136 S000000529KCC4YCL024WverifiedProtein kinase of the bud neck involved in the septincheckpoint, associates with septin proteins,negatively regulates Swe1p by phosphorylation,shows structural homology to bud neck kinasesGin4p and Hsl1p 1e-050.00136 S000003295SPT4YGR063CverifiedProtein that forms a complex with Spt5p and mediates bothactivation and inhibition of transcriptionelongation, and plays a role in pre-mRNAprocessing; in addition, Spt4p is involved inkinetochore function and gene silencing 1e-050.00136 S000000276HSP26YBR072WverifiedSmall heat shock protein with chaperone activity that isregulated by a heat induced transition from aninactive oligomeric (24-mer) complex to anactive dimer; induced by heat, upon entry intostationary phase, and during sporulation 1e-050.00136 S000002892VPS52YDR484WverifiedComponent of the GARP (Golgi-associated retrograde protein)complex, Vps51p-Vps52p-Vps53p-Vps54p, which isrequired for the recycling of proteins fromendosomes to the late Golgi; involved inlocalization of actin and chitin 1e-050.00136 S000006129RKM1YPL208WverifiedSET-domain lysine-N-methyltransferase, catalyzes the formationof dimethyllysine residues on the largeribsomal subunit protein L23a (RPL23A andRPL23B) 1e-050.00136 S000001400TPM2YIL138CverifiedMinor isoform of tropomyosin, binds to and stabilizes actincables and filaments, which direct polarizedcell growth and the distribution of severalorganelles; appears to have distinct and alsooverlapping functions with Tpm1p 1e-050.00136 S000000407COS111YBR203WverifiedProtein required for resistance to the antifungal drugciclopirox olamine; not related to thesubtelomerically-encoded COS family; theauthentic, non-tagged protein is detected inhighly purified mitochondria in high-throughputstudies 1e-050.00136 S000001550YNK1YKL067WverifiedNucleoside diphosphate kinase, catalyzes the transfer of gammaphosphates from nucleoside triphosphates,usually ATP, to nucleoside diphosphates by amechanism that involves formation of anautophosphorylated enzyme intermediate 1e-050.00136 S000004969YNL024CUncharacterizedPutative protein of unknown function with seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL024C is not an essential gene 1e-050.00136 S000003712SWI3YJL176CverifiedSubunit of the SWI/SNF chromatin remodeling complex, whichregulates transcription by remodelingchromosomes; required for transcription of manygenes, including ADH1, ADH2, GAL1, HO, INO1 andSUC2 1e-050.00136 S000003526PAU12YGR294WuncharacterizedHypothetical protein 1e-050.00136 S000005755WTM2YOR229WverifiedTranscriptional repressor involved in regulation of meiosis andsilencing; contains WD repeats 1e-050.00136 S000006362YPR158WUncharacterizedHypothetical protein 1e-050.00136 S000002448RSM10YDR041WverifiedMitochondrial ribosomal protein of the small subunit, hassimilarity to E. coli S10 ribosomal protein;essential for viability, unlike most othermitoribosomal proteins 1e-050.00136 S000004779ALD3YMR169CverifiedCytoplasmic aldehyde dehydrogenase, involved in beta-alaninesynthesis; uses NAD+ as the preferred coenzyme;very similar to Ald2p; expression is induced bystress and repressed by glucose 1e-050.00136 S000002860PPN1YDR452WverifiedVacuolar endopolyphosphatase with a role in phosphatemetabolism; functions as a homodimer 1e-050.00136 S000001070DAP2YHR028CverifiedDipeptidyl aminopeptidase, synthesized as a glycosylatedprecursor; localizes to the vacuolar membrane;similar to Ste13p 1e-050.00136 S000007223LUG1YCR087C-AuncharacterizedPutative protein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to thenucleolus; YCR087C-A is not an essential gene 1e-050.00136 S000000811NTF2YER009WverifiedNuclear envelope protein, interacts with GDP-bound Gsp1p andwith proteins of the nuclear pore to transportGsp1p into the nucleus where it is an essentialplayer in nucleocytoplasmic transport 1e-050.00136 S000002162ATP16YDL004WverifiedDelta subunit of the central stalk of mitochondrial F1F0 ATPsynthase, which is a large, evolutionarilyconserved enzyme complex required for ATPsynthesis 1e-050.00136 S000006315DBF20YPR111WverifiedSer/Thr kinase involved in late nuclear division, one of themitotic exit network (MEN) proteins; necessaryfor the execution of cytokinesis 1e-050.00136 S000002205SIT4YDL047WverifiedType 2A-related serine-threonine phosphatase that functions inthe G1/S transition of the mitotic cycle;cytoplasmic and nuclear protein that modulatesfunctions mediated by Pkc1p including cell walland actin cytoskeleton organization 1e-050.00136 S000004111YPS3YLR121CverifiedAspartic protease, attached to the plasma membrane via aglycosylphosphatidylinositol (GPI) anchor 1e-050.00136 S000000153PTH2YBL057CverifiedOne of two (see also PTH1) mitochondrially-localizedpeptidyl-tRNA hydrolases; negatively regulatesthe ubiquitin-proteasome pathway viainteractions with ubiquitin-likeubiquitin-associated proteins; dispensable forcell growth 1e-050.00136 S000004397DUS4YLR405WuncharacterizedDihydrouridine synthase, member of a widespread family ofconserved proteins including Smm1p, Dus1p, andDus3p 1e-050.00136 S000003692SSY5YJL156CverifiedProbable serine protease of the SPS plasma membrane amino acidsensor system (Ssy1p-Ptr3p-Ssy5p), which sensesexternal amino acid concentration and transmitsintracellular signals that regulate expressionof amino acid permease genes 1e-050.00136 S000001392ASG1YIL130WuncharacterizedProposed transcriptional activator, member of the Gal4p familyof zinc cluster proteins 1e-050.00136 S000004042IES3YLR052WverifiedSubunit of the INO80 chromatin remodeling complex 1e-050.00136 S000004362ARC18YLR370CverifiedSubunit of the ARP2/3 complex, which is required for themotility and integrity of cortical actinpatches 1e-050.00136 S000029704YHR199C-AUncharacterizedPutative protein of unknown function; transcribed sequence appears to contain an intron 1e-050.00136 S000005303YNR020CUncharacterizedHypothetical protein 1e-050.00136 S000001105PAN5YHR063Cverified2-dehydropantoate 2-reductase, part of the pantothenic acidpathway, structurally homologous to E. colipanE 1e-050.00136 S000003344SHY1YGR112WverifiedMitochondrial inner membrane protein required for normalrespiration, possible chaperone involved inassembly of cytochrome c oxidase; similar toSURF1 from mammals, chickens, and D.melanogaster 1e-050.00136 S000006095NIP100YPL174CverifiedLarge subunit of the dynactin complex, which is involved inpartitioning the mitotic spindle between motherand daughter cells; putative ortholog ofmammalian p150(glued) 1e-050.00136 S000028828YHL015W-AUncharacterizedPutative protein of unknown function 1e-050.00136 S000001833DDI2YFL061WuncharacterizedProtein whose expression is induced by DNA damage 1e-050.00136 S000001396FLX1YIL134WverifiedProtein required for transport of flavin adenine dinucleotide(FAD), a synthesis product of riboflavin,across the mitochondrial membrane 1e-050.00136 S000003601DLS1YJL065CverifiedSubunit of ISW2/yCHRAC chromatin accessibility complex alongwith Itc1p, Isw2p, and Dpb4p; involved ininheritance of telomeric silencing 1e-050.00136 S000003441TRX2YGR209CverifiedCytoplasmic thioredoxin isoenzyme of the thioredoxin systemwhich protects cells against both oxidative andreductive stress, forms LMA1 complex withPbi2p, acts as a cofactor for Tsa1p, requiredfor ER-Golgi transport and vacuole inheritance 1e-050.00136 S000000416NGR1YBR212WverifiedRNA binding protein that negatively regulates growth rate;interacts with the 3' UTR of the mitochondrialporin (POR1) mRNA and enhances its degradation;overexpression impairs mitochondrial function;expressed in stationary phase 1e-050.00136 S000028517YBL039W-BUncharacterizedPutative protein of unknown function 1e-050.00136 S000006014NOG1YPL093WverifiedPutative GTPase that associates with free 60S ribosomalsubunits in the nucleolus and is required for60S ribosomal subunit biogenesis; constituentof 66S pre-ribosomal particles; member of theODN family of nucleolar G-proteins 1e-050.00136 S000000598CIT2YCR005CverifiedCitrate synthase, catalyzes the condensation of acetyl coenzymeA and oxaloacetate to form citrate, peroxisomalisozyme involved in glyoxylate cycle;expression is controlled by Rtg1p and Rtg2ptranscription factors 1e-050.00136 S000005809YOR283WUncharacterizedPutative protein of unknown function with some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene 1e-050.00136 S000004550TUB1YML085CverifiedAlpha-tubulin; associates with beta-tubulin (Tub2p) to formtubulin dimer, which polymerizes to formmicrotubules 1e-050.00136 S000005001OCA2YNL056WuncharacterizedPutative protein with similarity to predicted tyrosinephosphatases Oca1p and Siw14p; greenfluorescent protein (GFP)-fusion proteinlocalizes to the cytoplasm; YNL056W is not anessential gene 1e-050.00136 S000004678YMR074CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR074C is not an essential gene 1e-050.00136 S000005653RGA1YOR127WverifiedGTPase-activating protein for the polarity-establishmentprotein Cdc42p; implicated in control of septinorganization, pheromone response, and haploidinvasive growth 1e-050.00136 S000001416IMP2'YIL154CverifiedTranscriptional activator involved in maintenance of ionhomeostasis and protection against DNA damagecaused by bleomycin and other oxidants,contains a C-terminal leucine-rich repeat 1e-050.00136 S000005937SWI1YPL016WverifiedSubunit of the SWI/SNF chromatin remodeling complex, whichregulates transcription by remodelingchromosomes; required for transcription of manygenes, including ADH1, ADH2, GAL1, HO, INO1 andSUC2 1e-050.00136 S000000894IES5YER092WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 1e-050.00136 S000006260TFB4YPR056WverifiedSubunit of TFIIH complex, involved in transcription initiation,similar to 34 kDa subunit of human TFIIH;interacts with Ssl1p 1e-050.00136 S000005376CMK2YOL016CverifiedCalmodulin-dependent protein kinase; may play a role in stressresponse, many CA++/calmodulan dependentphosphorylation substrates demonstrated invitro, amino acid sequence similar to Cmk1p andmammalian Cam Kinase II 1e-050.00136 S000002435REG1YDR028CverifiedRegulatory subunit of type 1 protein phosphatase Glc7p,involved in negative regulation ofglucose-repressible genes 1e-050.00136 S000004581DAT1YML113WverifiedDNA binding protein that recognizes oligo(dA).oligo(dT) tracts;Arg side chain in its N-terminal pentadGly-Arg-Lys-Pro-Gly repeat is required forDNA-binding; not essential for viability 1e-050.00136 S000028652YHR213W-BUncharacterizedPutative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 1e-050.00136 S000001457YAP5YIR018WverifiedBasic leucine zipper (bZIP) transcription factor 1e-050.00136 S000003782REC107YJR021CverifiedProtein involved in early stages of meiotic recombination;involved in altering chromatin structure at DNAdouble-stranded break sites and in coordinationbetween the initiation of recombination and thefirst division of meiosis 1e-050.00136 S000003986AYT1YLL063CverifiedAcetyltransferase; catalyzes trichothecene 3-O-acetylation,suggesting a possible role in trichothecenebiosynthesis 1e-050.00136 S000004985YNL040WUncharacterizedPutative protein of unknown function with strong similarity to alanyl-tRNA synthases from Eubacteria; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL040W is not an essential gene 1e-050.00136 S000003080TAF6YGL112CverifiedSubunit (60 kDa) of TFIID and SAGA complexes, involved intranscription initiation of RNA polymerase IIand in chromatin modification, similar tohistone H4 1e-050.00136 S000004462YML003WUncharacterizedHypothetical protein 1e-050.00136 S000028686YLR466C-BUncharacterizedDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data 1e-050.00136 S000001079PUT2YHR037WverifiedDelta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encodedmitochondrial protein involved in utilizationof proline as sole nitrogen source; deficiencyof the human homolog causes HPII, an autosomalrecessive inborn error of metabolism 1e-050.00136 S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 1e-050.00136 S000004972CRZ1YNL027WverifiedTranscription factor that activates transcription of genesinvolved in stress response; nuclearlocalization is positively regulated bycalcineurin-mediated dephosphorylation 1e-050.00136 S000002659PAM1YDR251WverifiedEssential protein of unknown function; exhibits variableexpression during colony morphogenesis;overexpression permits survival without proteinphosphatase 2A, inhibits growth, and induces afilamentous phenotype 1e-050.00136 S000005732NOC2YOR206WverifiedProtein that forms a nucleolar complex with Mak21p that bindsto 90S and 66S pre-ribosomes, as well as anuclear complex with Noc3p that binds to 66Spre-ribosomes; both complexes mediateintranuclear transport of ribosomal precursors 1e-050.00136 S000001170FUR1YHR128WverifiedUracil phosphoribosyltransferase, synthesizes UMP from uracil;involved in the pyrimidine salvage pathway 1e-050.00136 S000003435YGR203WUncharacterizedPutative protein with sequence similarity to protein tyrosine phosphatases of the CDC25-like phosphatase family; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 1e-050.00136 S000003499FOL2YGR267CverifiedGTP-cyclohydrolase I, catalyzes the first step in the folicacid biosynthetic pathway 1e-050.00136 S000001248SCH9YHR205WverifiedProtein kinase that regulates signal transduction activity andG1 progression, controls cAPK activity,required for nitrogen activation of the FGMpathway, involved in life span regulation,homologous to mammalian Akt/PKB 1e-050.00136 S000001603OAC1YKL120WverifiedMitochondrial inner membrane transporter, transportsoxaloacetate, sulfate, and thiosulfate; memberof the mitochondrial carrier family 1e-050.00136 S000005202DSL1YNL258CverifiedEndoplasmic reticulum (ER)-localized peripheral membraneprotein required for Golgi-to-ER retrogradetraffic; component of the ER target site thatinteracts with coatomer, the major component ofthe COPI vesicle protein coat 1e-050.00136 S000002128SBH1YER087C-BverifiedBeta subunit of the Sec61p ER translocation complex(Sec61p-Sss1p-Sbh1p); involved in proteintranslocation into the endoplasmic reticulum;interacts with the exocyst complex; homologousto Sbh2p 1e-050.00136 S000004365VID22YLR373CverifiedGlycosylated integral membrane protein localized to the plasmamembrane; plays a role infructose-1,6-bisphosphatase (FBPase)degradation; involved in FBPase transport fromthe cytosol to Vid (vacuole import anddegradation) vesicles 1e-050.00136 S000001016RIM4YHL024WverifiedPutative RNA-binding protein required for the expression ofearly and middle sporulation genes 1e-050.00136 S000002866HEH2YDR458CuncharacterizedProtein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to the nuclearperiphery 1e-050.00136 S000001923ECO1YFR027WverifiedAcetyltransferase required for the establishment of sisterchromatid cohesion during DNA replication, butnot for its maintenance during G2 and M phases;also required for postreplicative double-strandbreak repair; interacts with Chl1p 1e-050.00136 S000000762ANP1YEL036CverifiedSubunit of the alpha-1,6 mannosyltransferase complex; type IImembrane protein; has a role in retention ofglycosyltransferases in the Golgi; involved inosmotic sensitivity and resistance toaminonitrophenyl propanediol 1e-050.00136 S000003361SYF2YGR129WverifiedComponent of the spliceosome complex involved in pre-mRNAsplicing; involved in regulation of cell cycleprogression 1e-050.00136 S000028818YCR024C-BUncharacterizedPutative protein of unknown function; identified by expression profiling and mass spectrometry 1e-050.00136 S000002563RPA14YDR156WverifiedRNA polymerase I subunit A14 1e-050.00136 S000005225HCH1YNL281WverifiedHeat shock protein regulator that binds to Hsp90p and maystimulate ATPase activity; originallyidentified as a high-copy number suppressor ofa HSP90 loss-of-function mutation; GFP-fusionprotein localizes to the cytoplasm and nucleus 1e-050.00136 S000001507URA6YKL024CverifiedUridylate kinase, catalyzes the seventh enzymatic step in thede novo biosynthesis of pyrimidines, convertinguridine monophosphate (UMP) intouridine-5'-diphosphate (UDP) 1e-050.00136 S000004991YNL046WUncharacterizedPutative protein of unknown function; expression depends on Swi5p; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL046W is not an essential gene 1e-050.00136 S000003852BUD4YJR092WverifiedProtein involved in bud-site selection and required for axialbudding pattern; localizes with septins to budneck in mitosis and may constitute an axiallandmark for next round of budding; potentialCdc28p substrate 1e-050.00136 S000004640MSN2YMR037CverifiedTranscriptional activator related to Msn4p; activated in stressconditions, which results in translocation fromthe cytoplasm to the nucleus; binds DNA atstress response elements of responsive genes,inducing gene expression 1e-050.00136 S000002382HBT1YDL223CverifiedSubstrate of the Hub1p ubiquitin-like protein that localizes tothe shmoo tip (mating projection); mutants aredefective for mating projection formation,thereby implicating Hbt1p in polarized cellmorphogenesis 1e-050.00136 S000003744NUC1YJL208CverifiedMajor mitochondrial nuclease, has RNAse and DNA endo- andexonucleolytic activities; has a role inmitochondrial recombination 1e-050.00136 S000000547YCL042WUncharacterizedHypothetical protein 1e-050.00136 S000001568MDH1YKL085WverifiedMitochondrial malate dehydrogenase, catalyzes interconversionof malate and oxaloacetate; involved in thetricarboxylic acid (TCA) cycle 1e-050.00136 S000006306RPL11AYPR102CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl11Bp; involved in ribosomalassembly; depletion causes degradation ofproteins and RNA of the 60S subunit; hassimilarity to E. coli L5 and rat L11 1e-050.00136 S000001686TOR2YKL203CverifiedPIK-related protein kinase and rapamycin target; subunit ofTORC1, a complex that regulates growth inresponse to nutrients and TORC2, a complex thatregulates cell-cycle dependent polarization ofthe actin cytoskeleton; involved in meiosis 1e-050.00136 S000004075ARP6YLR085CverifiedActin-related protein that binds nucleosomes; a component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 1e-050.00136 S000000968DNF1YER166WverifiedAminophospholipid translocase (flippase) that localizesprimarily to the plasma membrane; contributesto endocytosis, protein transport and cellpolarity; type 4 P-type ATPase 1e-050.00136 S000004039YLR049CUncharacterizedHypothetical protein 1e-050.00136 S000002277YDL119CUncharacterizedPutative mitochondrial transport protein; localizes to the mitochondrion; YDL119C is not an essential gene 1e-050.00136 S000003178YPT32YGL210WverifiedGTPase of the Ypt/Rab family, very similar to Ypt31p; involvedin the exocytic pathway; mediates intra-Golgitraffic or the budding of post-Golgi vesiclesfrom the trans-Golgi 1e-050.00136 S000001059YSC83YHR017WverifiedNon-essential mitochondrial protein of unknown function; mRNAinduced during meiosis, peaking between mid tolate prophase of meiosis I; similar to S.douglasii YSD83 1e-050.00136 S000006235NTO1YPR031WuncharacterizedComponent of the histone acetyltransferase complex 1e-050.00136 S000001774CCP1YKR066CverifiedMitochondrial cytochrome-c peroxidase; degrades reactive oxygenspecies in mitochondria, involved in theresponse to oxidative stress 1e-050.00136 S000004298CDA1YLR307WverifiedChitin deacetylase, together with Cda2p involved in thebiosynthesis ascospore wall component,chitosan; required for proper rigidity of theascospore wall 1e-050.00136 S000006335NAT3YPR131CverifiedCatalytic subunit of the NatB N-terminal acetyltransferase,which catalyzes acetylation of theamino-terminal methionine residues of allproteins beginning with Met-Asp or Met-Glu andof some proteins beginning with Met-Asn orMet-Met 1e-050.00136 S000002736SKP1YDR328CverifiedEvolutionarily conserved kinetochore protein that is part ofmultiple protein complexes, including the SCFubiquitin ligase complex, the CBF3 complex thatbinds centromeric DNA, and the RAVE complexthat regulates assembly of the V-ATPase 1e-050.00136 S000001144KIC1YHR102WverifiedProtein kinase of the PAK/Ste20 kinase family, required forcell integrity possibly through regulating1,6-beta-glucan levels in the wall; physicallyinteracts with Cdc31p (centrin), which is acomponent of the spindle pole body 1e-050.00136 S000004315CWC24YLR323CverifiedEssential protein, component of a complex containing Cef1p; hassimilarity to S. pombe Cwf24p 1e-050.00136 S000000299RXT2YBR095CverifiedSubunit of the histone deacetylase Rpd3L complex; possiblyinvolved in cell fusion and invasive growth 1e-050.00136 S000005584ASE1YOR058CverifiedMember of a family of microtubule-associated proteins (MAPs)that function at the mitotic spindle midzone;required for spindle elongation; undergoes cellcycle-regulated degradation by anaphasepromoting complex; potential Cdc28p substrate 1e-050.00136 S000003067LSG1YGL099WverifiedPutative GTPase involved in 60S ribosomal subunit biogenesis;required for the release of Nmd3p from 60Ssubunits in the cytoplasm 1e-050.00136 S000006275YPR071WUncharacterizedHypothetical protein 1e-050.00136 S000001910CMK1YFR014CverifiedCalmodulin-dependent protein kinase; may play a role in stressresponse, many CA++/calmodulan dependentphosphorylation substrates demonstrated invitro, amino acid sequence similar to Cmk2p andmammalian Cam Kinase II 1e-050.00136 S000001397VHS2YIL135CverifiedCytoplasmic protein of unknown function; identified as ahigh-copy suppressor of the synthetic lethalityof a sis2 sit4 double mutant, suggesting a rolein G1/S phase progression; similar to Mlf3p 1e-050.00136 S000005678YOR152CUncharacterizedHypothetical protein 1e-050.00136 S000000112FUS3YBL016WverifiedMitogen-activated protein kinase involved in mating pheromoneresponse; activated by phosphorylation bySte7p; provides specificity during the matingvs. filamentous growth response byphosphorylating transcriptional and cytoplasmictargets 1e-050.00136 S000001610PGM1YKL127WverifiedPhosphoglucomutase, minor isoform; catalyzes the conversionfrom glucose-1-phosphate toglucose-6-phosphate, which is a key step inhexose metabolism 1e-050.00136 S000000492APM3YBR288CverifiedMu3-like subunit of the clathrin associated protein complex(AP-3); functions in transport of alkalinephosphatase to the vacuole via the alternatepathway 1e-050.00136 S000005379YOL019WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole 1e-050.00136 S000001415RRD1YIL153WverifiedActivator of the phosphotyrosyl phosphatase activity of PP2A;regulates G1 phase progression, the G2/M phasetransition, microtubule dynamics, theosmoresponse, bud morphogenesis and DNA repair;subunit of the Tap42p-Sit4p-Rrd1p complex 1e-050.00136 S000006349ASN1YPR145WverifiedAsparagine synthetase, isozyme of Asn2p; catalyzes thesynthesis of L-asparagine from L-aspartate inthe asparagine biosynthetic pathway 1e-050.00136 S000006179THI21YPL258CverifiedHydroxymethylpyrimidine phosphate kinase, involved in the laststeps in thiamine biosynthesis; member of agene family with THI20 and THI22; functionallyredundant with Thi20p 1e-050.00136 S000003716ATP12YJL180CverifiedConserved protein required for assembly of alpha and betasubunits into the F1 sector of mitochondrialF1F0 ATP synthase; mutation of human ATP12reduces active ATP synthase levels and isassociated with the disorder ATPAF2 deficiency 1e-050.00136 S000001129YHR087WVerifiedProtein involved in RNA metabolism, one of two yeast homologs (with Sdo1p/Ylr022cp) of the human protein SBDS responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome, also conserved in Archaea 1e-050.00136 S000001220YHR177WUncharacterized 1e-050.00136 S000005486MDH2YOL126CverifiedCytoplasmic malate dehydrogenase, one of the three isozymesthat catalyze interconversion of malate andoxaloacetate; involved in gluconeogenesisduring growth on ethanol or acetate as carbonsource; interacts with Pck1p and Fbp1p 1e-050.00136 S000002781FRQ1YDR373WverifiedN-myristoylated calcium-binding protein that may have a role inintracellular signaling through its regulationof the phosphatidylinositol 4-kinase Pik1p;member of the recoverin/frequenin branch of theEF-hand superfamily 1e-050.00136 S000000102LDB7YBL006CverifiedComponent of the RSC chromatin remodeling complex; interactswith Rsc3p, Rsc30p, Npl6p, and Htl1p to form amodule important for a broad range of RSCfunctions 1e-050.00136 S000001394CSM2YIL132CverifiedProtein required for accurate chromosome segregation duringmeiosis 1e-050.00136 S000005173URE2YNL229CverifiedNitrogen catabolite repression regulator that acts byinhibition of GLN3 transcription in goodnitrogen source; altered form of Ure2p creates[URE3] prion 1e-050.00136 S000005448MPD2YOL088CverifiedMember of the protein disulfide isomerase (PDI) family,exhibits chaperone activity; overexpressionsuppresses the lethality of a pdi1 deletion butdoes not complement all Pdi1p functions;undergoes oxidation by Ero1p 1e-050.00136 S000003252VMA7YGR020CverifiedSubunit F of the eight-subunit V1 peripheral membrane domain ofvacuolar H+-ATPase (V-ATPase), an electrogenicproton pump found throughout the endomembranesystem; required for the V1 domain to assembleonto the vacuolar membrane 1e-050.00136 S000002463YDR056CUncharacterizedHypothetical protein 1e-050.00136 S000005599SGO1YOR073WverifiedComponent of the spindle checkpoint, involved in sensing lackof tension on mitotic chromosomes; protectscentromeric Rec8p at meiosis I; required foraccurate chromosomal segregation at meiosis IIand for mitotic chromosome stability 1e-050.00136 S000005993UBP16YPL072WverifiedDeubiquitinating enzyme anchored to the outer mitochondrialmembrane, probably not important for generalmitochondrial functioning, but may perform amore specialized function at mitochondria 1e-050.00136 S000004824DML1YMR211WverifiedEssential protein involved in mtDNA inheritance, may alsofunction in the partitioning of themitochondrial organelle or in the segregationof chromosomes, exhibits regions similar tomembers of a GTPase family 1e-050.00136 S000000502MAL31YBR298CverifiedMaltose permease, high-affinity maltose transporter(alpha-glucoside transporter); encoded in theMAL3 complex locus; member of the 12transmembrane domain superfamily of sugartransporters; functional in genomic referencestrain S288C 1e-050.00136 S000002570CWC15YDR163WverifiedNon-essential protein involved in pre-mRNA splicing, componentof a complex containing Cef1p; has similarityto S. pombe Cwf15p 1e-050.00136 S000005499CDC33YOL139CverifiedCytoplasmic mRNA cap binding protein; the eIF4E-cap complex isresponsible for mediating cap-dependent mRNAtranslation via interactions with thetranslation initiation factor eIF4G (Tif4631por Tif4632p) 1e-050.00136 S000001471DAL3YIR032CverifiedUreidoglycolate hydrolase, converts ureidoglycolate toglyoxylate and urea in the third step ofallantoin degradation; expression sensitive tonitrogen catabolite repression 1e-050.00136 S000006384AOS1YPR180WverifiedNuclear protein that acts as a heterodimer with Uba2p toactivate Smt3p (SUMO) before its conjugation toproteins (sumoylation), which may play a rolein protein targeting; essential for viability 1e-050.00136 S000001712ECM9YKR004CverifiedNon-essential protein of unknown function 1e-050.00136 S000003814BFA1YJR053WverifiedComponent of the GTPase-activating Bfa1p-Bub2p complex involvedin multiple cell cycle checkpoint pathways thatcontrol exit from mitosis 1e-050.00136 S000003078CUE3YGL110CuncharacterizedProtein of unknown function; has a CUE domain that bindsubiquitin, which may facilitate intramolecularmonoubiquitination 1e-050.00136 S000007496IGO2YHR132W-AuncharacterizedPutative protein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to the cytoplasmand nucleus 1e-050.00136 S000003844CSN12YJR084WverifiedSubunit of the Cop9 signalosome, which is required fordeneddylation, or removal of the ubiquitin-likeprotein Rub1p from Cdc53p (cullin); involved inadaptation to pheromone signaling 1e-050.00136 S000006215YPR011CUncharacterizedHypothetical protein 1e-050.00136 S000002911LPP1YDR503CverifiedLipid phosphate phosphatase, catalyzes Mg(2+)-independentdephosphorylation of phosphatidic acid (PA),lysophosphatidic acid, and diacylglycerolpyrophosphate; involved in control of thecellular levels of phosphatidylinositol and PA 1e-050.00136 S000004097REX3YLR107WverifiedRNA exonuclease; required for maturation of the RNA componentof RNase MRP; functions redundantly with Rnh70pand Rex2p in processing of U5 snRNA and RNase PRNA; member of RNase D family of exonucleases 1e-050.00136 S000001792HBS1YKR084CverifiedGTP binding protein with sequence similarity to the elongationfactor class of G proteins, EF-1alpha andSup35p; associates with Dom34p, and shares asimilar genetic relationship with genes thatencode ribosomal protein components 1e-050.00136 S000001658ZRT3YKL175WverifiedVacuolar membrane zinc transporter, transports zinc fromstorage in the vacuole to the cytoplasm whenneeded; transcription is induced underconditions of zinc deficiency 1e-050.00136 S000004838MRPL44YMR225CverifiedMitochondrial ribosomal protein of the large subunit 1e-050.00136 S000000682CSM1YCR086WverifiedNucleolar protein that forms a complex with Lrs4p which bindsMam1p at kinetochores during meiosis I tomediate accurate chromosome segregation, may beinvolved in premeiotic DNA replication;possible role in telomere maintenance 1e-050.00136 S000004236ERF2YLR246WverifiedSubunit of a palmitoyltransferase, composed of Erf2p and Shr5p,that adds a palmitoyl lipid moiety toheterolipidated substrates such as Ras1p andRas2p through a thioester linkage; mutantspartially mislocalize Ras2p to the vacuole 1e-050.00136 S000004957SPO1YNL012WverifiedMeiosis-specific protein with similarity to phospholipase B,required for meiotic spindle pole bodyduplication and separation; required for sporeformation 1e-050.00136 S000028527YPL189C-AUncharacterizedIdentified by homology to Ashbya gossypii 1e-050.00136 S000002955YEL076C-AUncharacterizedHypothetical protein 1e-050.00136 S000000121RRN10YBL025WverifiedProtein involved in promoting high level transcription of rDNA,subunit of UAF (upstream activation factor) forRNA polymerase I 1e-050.00136 S000000994HSE1YHL002WverifiedSubunit of the endosomal Vps27p-Hse1p complex required forsorting of ubiquitinated membrane proteins intointralumenal vesicles prior to vacuolardegradation, as well as for recycling of Golgiproteins and formation of lumenal membranes 1e-050.00136 S000004659BUB2YMR055CverifiedMitotic exit network regulator, forms GTPase-activatingBfa1p-Bub2p complex that binds Tem1p andspindle pole bodies, blocks cell cycleprogression before anaphase in response tospindle and kinetochore damage 1e-050.00136 S000007232STF1YDL130W-AverifiedProtein involved in regulation of the mitochondrial F1F0-ATPsynthase; Stf1p and Stf2p act as stabilizingfactors that enhance inhibitory action of theInh1p protein 1e-050.00136 S000005026PMS1YNL082WverifiedATP-binding protein required for mismatch repair in mitosis andmeiosis; functions as a heterodimer with Mlh1p,binds double- and single-stranded DNA via itsN-terminal domain, similar to E. coli MutL 1e-050.00136 S000000417MET8YBR213WverifiedBifunctional dehydrogenase and ferrochelatase, involved in thebiosynthesis of siroheme; also involved in theexpression of PAPS reductase and sulfitereductase 1e-050.00136 S000003917THI11YJR156CverifiedProtein involved in synthesis of the thiamine precursorhydroxymethylpyrimidine (HMP); member of asubtelomeric gene family including THI5, THI11,THI12, and THI13 1e-050.00136 S000001365DPH1YIL103WverifiedProtein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p,for synthesis of diphthamide, which is amodified histidine residue of translationelongation factor 2 (Eft1p or Eft2p); may actin a complex with Dph2p and Kti11p 1e-050.00136 S000006247RPL43AYPR043WverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl43Bp and has similarity to ratL37a ribosomal protein; null mutation confers adominant lethal phenotype 1e-050.00136 S000003606YJL070CUncharacterizedPutative protein of unknown function with similarity to AMP deaminases; YJL070C is a non-essential gene 1e-050.00136 S000000630FEN1YCR034WverifiedFatty acid elongase, involved in sphingolipid biosynthesis;acts on fatty acids of up to 24 carbons inlength; mutations have regulatory effects on1,3-beta-glucan synthase, vacuolar ATPase, andthe secretory pathway 1e-050.00136 S000003387CYS4YGR155WverifiedCystathionine beta-synthase, catalyzes the synthesis ofcystathionine from serine and homocysteine, thefirst committed step in cysteine biosynthesis 1e-050.00136 S000000427TDP1YBR223CverifiedTyrosyl-DNA Phosphodiesterase I, hydrolyzes 3'-phosphotyrosylbonds to generate 3'-phosphate DNA andtyrosine, involved in the repair of DNA lesionscreated by topoisomerase I 1e-050.00136 S000006430MRP10YDL045W-AverifiedMitochondrial ribosomal protein of the small subunit 1e-050.00136 S000005382YOL022CUncharacterizedProtein required for cell viability 1e-050.00136 S000004899MRPL33YMR286WverifiedMitochondrial ribosomal protein of the large subunit 1e-050.00136 S000003440SER2YGR208WverifiedPhosphoserine phosphatase of the phosphoglycerate pathway,involved in serine and glycine biosynthesis,expression is regulated by the availablenitrogen source 1e-050.00136 S000000270NRG2YBR066CverifiedTranscriptional repressor that mediates glucose repression andnegatively regulates filamentous growth; hassimilarity to Nrg1p 1e-050.00136 S000002218TSR1YDL060WverifiedProtein required for processing of 20S pre-rRNA in thecytoplasm, associates with pre-40S ribosomalparticles 1e-050.00136 S000003831LIA1YJR070CverifiedDeoxyhypusine hydroxylase, a HEAT-repeat containingmetalloenzyme that catalyses hypusineformation; binds to and is required for themodification of Hyp2p (eIF5A); complements S.pombe mmd1 mutants defective in mitochondrialpositioning 1e-050.00136 S000001701SRY1YKL218Cverified3-hydroxyaspartate dehydratase, deaminatesL-threo-3-hydroxyaspartate to form oxaloacetateand ammonia; required for survival in thepresence of hydroxyaspartate 1e-050.00136 S000000696YCR099CUncharacterizedHypothetical protein 1e-050.00136 S000002341LYS20YDL182WverifiedHomocitrate synthase isozyme, catalyzes the condensation ofacetyl-CoA and alpha-ketoglutarate to formhomocitrate, which is the first step in thelysine biosynthesis pathway; highly similar tothe other isozyme, Lys21p 1e-050.00136 S000002320ENT1YDL161WverifiedEpsin-like protein involved in endocytosis and actin patchassembly and functionally redundant with Ent2p;binds clathrin via a clathrin-binding domainmotif at C-terminus 1e-050.00136 S000004821ERG12YMR208WverifiedMevalonate kinase, acts in the biosynthesis of isoprenoids andsterols, including ergosterol, from mevalonate 1e-050.00136 S000005361PHO80YOL001WverifiedCyclin, negatively regulates phosphate metabolism;Pho80p-Pho85p (cyclin-CDK complex)phosphorylates Pho4p and Swi5p; deletion ofPHO80 leads to aminoglycoside supersensitivity;truncated form of PHO80 affects vacuoleinheritance 1e-050.00136 S000001526PHD1YKL043WverifiedTranscriptional activator that enhances pseudohyphal growth;regulates expression of FLO11, an adhesinrequired for pseudohyphal filament formation;similar to StuA, an A. nidulans developmentalregulator; potential Cdc28p substrate 1e-050.00136 S000005557CRS5YOR031WverifiedCopper-binding metallothionein, required for wild-type copperresistance 1e-050.00136 S000005854SNC2YOR327CverifiedVesicle membrane receptor protein (v-SNARE) involved in thefusion between Golgi-derived secretory vesicleswith the plasma membrane; member of thesynaptobrevin/VAMP family of R-type v-SNAREproteins 1e-050.00136 S000003242NMA2YGR010WverifiedNicotinic acid mononucleotide adenylyltransferase, involved inNAD(+) salvage pathway 1e-050.00136 S000004784DDR48YMR173WverifiedDNA damage-responsive protein, expression is increased inresponse to heat-shock stress or treatmentsthat produce DNA lesions; contains multiplerepeats of the amino acid sequence NNNDSYGS 1e-050.00136 S000004519SPC2YML055WverifiedSubunit of signal peptidase complex (Spc1p, Spc2p, Spc3p,Sec11p), which catalyzes cleavage of N-terminalsignal sequences of proteins targeted to thesecretory pathway; homologous to mammalianSPC25 1e-050.00136 S000005663SIA1YOR137CverifiedProtein of unassigned function involved in activation of thePma1p plasma membrane H+-ATPase by glucose 1e-050.00136 S000002799YDR391CUncharacterizedHypothetical protein 1e-050.00136 S000004722ASC1YMR116CverifiedWD repeat protein (G-beta like protein) involved in translationregulation; required for repression of Gcn4pactivity in the absence of amino-acidstarvation; core component of the ribosome;ortholog of mammalian RACK1 1e-050.00136 S000004227THI7YLR237WverifiedPlasma membrane transporter responsible for the uptake ofthiamine, member of the major facilitatorsuperfamily of transporters; mutation of humanortholog causes thiamine-responsivemegaloblastic anemia 1e-050.00136 S000028654YHR214C-EUncharacterizedIdentified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 1e-050.00136 S000002413SOK1YDR006CverifiedProtein whose overexpression suppresses the growth defect ofmutants lacking protein kinase A activity;involved in cAMP-mediated signaling; localizedto the nucleus; similar to the mousetestis-specific protein PBS13 1e-050.00136 S000003119NUT1YGL151WverifiedComponent of the RNA polymerase II mediator complex, which isrequired for transcriptional activation andalso has a role in basal transcription 1e-050.00136 S000004442HMG2YLR450WverifiedOne of two isozymes of HMG-CoA reductase that convert HMG-CoAto mevalonate, a rate-limiting step in sterolbiosynthesis; overproduction induces assemblyof peripheral ER membrane arrays and shortnuclear-associated membrane stacks 1e-050.00136 S000000671ERS1YCR075CverifiedProtein with similarity to human cystinosin, which is aH(+)-driven transporter involved in L-cystineexport from lysosomes and implicated in thedisease cystinosis; contains seventransmembrane domains 1e-050.00136 S000004363ROM2YLR371WverifiedGDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutationsare synthetically lethal with mutations inrom1, which also encodes a GEP 1e-050.00136 S000003701HAL5YJL165CverifiedPutative protein kinase; overexpression increases sodium andlithium tolerance, whereas gene disruptionincreases cation and low pH sensitivity andimpairs potassium uptake, suggesting a role inregulation of Trk1p and/or Trk2p transporters 1e-050.00136 S000003664PBS2YJL128CverifiedMAP kinase kinase that plays a pivotal role in the osmosensingsignal-transduction pathway, activated undersevere osmotic stress 1e-050.00136 S000005430NUF2YOL069WverifiedComponent of the evolutionarily conservedkinetochore-associated Ndc80 complex(Ndc80p-Nuf2p-Spc24p-Spc25p); involved inchromosome segregation, spindle checkpointactivity and kinetochore clustering 1e-050.00136 S000005037YPT53YNL093WverifiedGTPase, similar to Ypt51p and Ypt52p and to mammalian rab5;required for vacuolar protein sorting andendocytosis 1e-050.00136 S000006008YDC1YPL087WverifiedAlkaline dihydroceramidase, involved in sphingolipidmetabolism; preferentially hydrolyzesdihydroceramide to a free fatty acid anddihydrosphingosine; has a minor reverseactivity 1e-050.00136 S000001534SFK1YKL051WverifiedPlasma membrane protein that may act together with or upstreamof Stt4p to generate normal levels of theessential phospholipid PI4P, at least partiallymediates proper localization of Stt4p to theplasma membrane 1e-050.00136 S000006371MET16YPR167Cverified3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylylsulfate to adenosine-3',5'-bisphosphate andfree sulfite using reduced thioredoxin ascosubstrate, involved in sulfate assimilationand methionine metabolism 1e-050.00136 S000003357YGR125WUncharacterizedPutative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole 1e-050.00136 S000004128NHA1YLR138WverifiedNa+/H+ antiporter involved in sodium and potassium effluxthrough the plasma membrane; required foralkali cation tolerance at acidic pH 1e-050.00136 S000005792PNT1YOR266WverifiedMitochondrial inner membrane protein involved in export ofproteins from the mitochondrial matrix;overexpression of PNT1 confers resistance tothe anti-Pneumocystis carinii drug pentamidine,and deletion confers increased sensitivity 1e-050.00136 S000005929CHL1YPL008WverifiedConserved nuclear protein required to establishsister-chromatid pairing during S-phase,probable DNA helicase with similarity to humanBACH1, which associates with tumor suppressorBRCA1; associates with acetyltransferase Ctf7p 1e-050.00136 S000001638RSM22YKL155CverifiedMitochondrial ribosomal protein of the small subunit 1e-050.00136 S000005316ABZ1YNR033WverifiedPara-aminobenzoate (PABA) synthase, has similarity toEscherichia coli PABA synthase components PabAand PabB 1e-050.00136 S000001621MRPL31YKL138CverifiedMitochondrial ribosomal protein of the large subunit 1e-050.00136 S000000836YER034WUncharacterizedHypothetical protein 1e-050.00136 S000005437BRX1YOL077CverifiedNucleolar protein, constituent of 66S pre-ribosomal particles;depletion leads to defects in rRNA processingand a block in the assembly of large ribosomalsubunits; possesses a sigma(70)-likeRNA-binding motif 1e-050.00136 S000003198SAP4YGL229CverifiedProtein required for function of the Sit4p protein phosphatase,member of a family of similar proteins thatform complexes with Sit4p, including Sap155p,Sap185p, and Sap190p 1e-050.00136 S000004590GTR1YML121WverifiedCytoplasmic GTP binding protein and negative regulator, withhomolog Gtr2p, of the Ran/Tc4 GTPase cycle;component of GSE complex, which is required forsorting of Gap1p; involved in phosphatetransport; has homology to human RagA and RagB 1e-050.00136 S000002299RPO21YDL140CverifiedRNA polymerase II largest subunit B220, part of central core;phosphorylation of C-terminal heptapeptiderepeat domain regulates association withtranscription and splicing factors; similar tobacterial beta-prime 1e-050.00136 S000003449CCH1YGR217WverifiedVoltage-gated high-affinity calcium channel involved in calciuminflux in response to some environmentalstresses as well as exposure to matingpheromones; interacts and co-localizes withMid1p, suggesting Cch1p and Mid1p functiontogether 1e-050.00136 S000007260COX1Q0045verifiedSubunit I of cytochrome c oxidase, which is the terminal memberof the mitochondrial inner membrane electrontransport chain; one of threemitochondrially-encoded subunits 1e-050.00136 S000002206STP4YDL048CverifiedProtein containing a Kruppel-type zinc-finger domain; hassimilarity to Stp1p, Stp2p, and Stp3p 1e-050.00136 S000004415ATG17YLR423CverifiedProtein that interacts with and is required for activation ofApg1p protein kinase; involved in autophagy butnot in the Cvt (cytoplasm to vacuole targeting)pathway 1e-050.00136 S000002232BRE1YDL074CverifiedE3 ubiquitin ligase for Rad6p, required for the ubiquitinationof histone H2B, recruitment of Rad6p topromoter chromatin and subsequent methylationof histone H3 (on L4 and L79), contains RINGfinger domain 1e-050.00136 S000000150YBL054WUncharacterizedHypothetical protein 1e-050.00136 S000006155TFP3YPL234CverifiedVacuolar ATPase V0 domain subunit c', involved in protontransport activity; hydrophobic integralmembrane protein (proteolipid) containing fourtransmembrane segments; N and C termini are inthe vacuolar lumen 1e-050.00136 S000003403MSM1YGR171CverifiedMitochondrial methionyl-tRNA synthetase (MetRS), functions as amonomer in mitochondrial protein synthesis;functions similarly to cytoplasmic MetRSalthough the cytoplasmic form contains azinc-binding domain not found in Msm1p 1e-050.00136 S000005916YOR389WUncharacterizedHypothetical protein 1e-050.00136 S000000319LYS2YBR115CverifiedAlpha aminoadipate reductase, catalyzes the reduction ofalpha-aminoadipate to alpha-aminoadipate6-semialdehyde, which is the fifth step inbiosynthesis of lysine; activation requiresposttranslational phosphopantetheinylation byLys5p 1e-050.00136 S000004551ALO1YML086CverifiedD-Arabinono-1,4-lactone oxidase, catalyzes the final step inbiosynthesis of D-erythroascorbic acid, whichis protective against oxidative stress 1e-050.00136 S000004478PPZ1YML016CverifiedSerine/threonine protein phosphatase Z, isoform of Ppz2p;involved in regulation of potassium transport,which affects osmotic stability, cell cycleprogression, and halotolerance 1e-050.00136 S000000745MMS21YEL019CverifiedSUMO ligase involved in chromosomal organization and DNArepair; essential subunit of theMms21-Smc5-Smc6 complex; mutants are sensitiveto methyl methanesulfonate and show increasedspontaneous mutation and mitotic recombination 1e-050.00136 S000004177SKG3YLR187WuncharacterizedProtein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to the cellperiphery, cytoplasm, bud, and bud neck;potential Cdc28p substrate; similar to Caf120pand Skg4p 1e-050.00136 S000002496YDR089WUncharacterizedHypothetical protein 1e-050.00136 S000004307NKP2YLR315WverifiedNon-essential kinetochore protein, subunit of the Ctf19 centralkinetochore complex(Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p) 1e-050.00136 S000000403KTR4YBR199WverifiedPutative mannosyltransferase involved in protein glycosylation;member of the KRE2/MNT1 mannosyltransferasefamily 1e-050.00136 S000001313MMF1YIL051CverifiedMitochondrial protein involved in maintenance of themitochondrial genome 1e-050.00136 S000028677YLR157W-DUncharacterizedPutative protein of unknown function identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 1e-050.00136 S000000508YCL002CUncharacterizedPutative protein of unknown function; YCL002C is not an essential gene 1e-050.00136 S000001285YKE4YIL023CverifiedZinc transporter; localizes to the ER; null mutant is sensitiveto calcofluor white, leads to zinc accumulationin cytosol; ortholog of the mouse KE4 andmember of the ZIP (ZRT, IRT-like Protein)family 1e-050.00136 S000003717YJL181WUncharacterizedHypothetical protein 1e-050.00136 S000002824SYF1YDR416WverifiedComponent of the spliceosome complex involved in pre-mRNAsplicing; involved in regulation of cell cycleprogression; similar to Drosophila crooked neckprotein 1e-050.00136 S000005298SMM1YNR015WverifiedDihydrouridine synthase, member of a family of dihydrouridinesynthases including Dus1p, Smm1p, Dus3p, andDus4p; modifies uridine residues at position 20of cytoplasmic tRNAs 1e-050.00136 S000000103SLA1YBL007CverifiedCytoskeletal protein binding protein required for assembly ofthe cortical actin cytoskeleton; contains 3 SH3domains; interacts with proteins regulatingactin dynamics and with proteins required forendocytosis 1e-050.00136 S000005839RPL20BYOR312CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl20Ap and has similarity to ratL18a ribosomal protein 1e-050.00136 S000005586YOR060CUncharacterizedProtein required for cell viability 1e-050.00136 S000005806FSH3YOR280CverifiedSerine hydrolase; sequence is similar to Fsh1p and Fsh2p 1e-050.00136 S000000657YCR061WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 1e-050.00136 S000002947YDR539WUncharacterizedHypothetical protein 1e-050.00136 S000005154MER1YNL210WverifiedProtein with RNA-binding motifs required for meiosis-specificmRNA splicing; required for chromosome pairingand meiotic recombination 1e-050.00136 S000000979BMH1YER177Wverified14-3-3 protein, major isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others 1e-050.00136 S000002976PMA1YGL008CverifiedPlasma membrane H+-ATPase, pumps protons out of the cell; majorregulator of cytoplasmic pH and plasma membranepotential; part of the P2 subgroup ofcation-transporting ATPases 1e-050.00136 S000000285SPT7YBR081CverifiedSubunit of the SAGA transcriptional regulatory complex,involved in proper assembly of the complex;also present as a C-terminally truncated formin the SLIK/SALSA transcriptional regulatorycomplex 1e-050.00136 S000004412URA4YLR420WverifiedDihydroorotase, catalyzes the third enzymatic step in the denovo biosynthesis of pyrimidines, convertingcarbamoyl-L-aspartate into dihydroorotate 1e-050.00136 S000000948LSM5YER146WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 1e-050.00136 S000001494CCE1YKL011CverifiedMitochondrial cruciform cutting endonuclease, cleaves Hollidayjunctions formed during recombination ofmitochondrial DNA 1e-050.00136 S000002459DBF4YDR052CverifiedRegulatory subunit of Cdc7p-Dbf4p kinase complex, required forCdc7p kinase activity and initiation of DNAreplication; phosphorylates the Mcm2-7 familyof proteins; cell cycle regulated 1e-050.00136 S000004299CDA2YLR308WverifiedChitin deacetylase, together with Cda1p involved in thebiosynthesis ascospore wall component,chitosan; required for proper rigidity of theascospore wall 1e-050.00136 S000005622RPS7AYOR096WverifiedProtein component of the small (40S) ribosomal subunit, nearlyidentical to Rps7Bp; interacts with Kti11p;deletion causes hypersensitivity to zymocin;has similarity to rat S7 and Xenopus S8ribosomal proteins 1e-050.00136 S000004329VRP1YLR337CverifiedProline-rich actin-associated protein involved in cytoskeletalorganization and cytokinesis; related tomammalian Wiskott-Aldrich syndrome protein(WASP)-interacting protein (WIP) 1e-050.00136 S000001269NAS2YIL007CverifiedProtein with similarity to the p27 subunit of mammalianproteasome modulator; not essential; interactswith Rpn4p 1e-050.00136 S000004935DIA1YMR316WverifiedProtein of unknown function, involved in invasive andpseudohyphal growth; green fluorescent protein(GFP)-fusion protein localizes to the cytoplasmin a punctate pattern 1e-050.00136 S000003635CHS6YJL099WverifiedMember of the Chs5p-Arf1p-binding proteins (ChAPs), a group of4 related, interacting proteins (Bch1p, Fmp50p,Bud7p, Chs6p) that mediate export of specificcargo proteins, including chitin synthaseChs3p, from the Golgi to plasma membrane 1e-050.00136 S000003089GPG1YGL121CverifiedProposed gamma subunit of the heterotrimeric G protein thatinteracts with the receptor Grp1p; involved inregulation of pseudohyphal growth; requiresGpb1p or Gpb2p to interact with Gpa2p 1e-050.00136 S000001844ALR2YFL050CverifiedProbable Mg(2+) transporter; overexpression confers increasedtolerance to Al(3+) and Ga(3+) ions 1e-050.00136 S000001588YKL105CUncharacterizedPutative protein of unknown function 1e-050.00136 S000004355NMD4YLR363CverifiedProtein interacting with Nam7p, may be involved in thenonsense-mediated mRNA decay pathway 1e-050.00136 S000005251MCK1YNL307CverifiedProtein serine/threonine/tyrosine (dual-specificity) kinaseinvolved in control of chromosome segregationand in regulating entry into meiosis; relatedto mammalian glycogen synthase kinases of theGSK-3 family 1e-050.00136 S000005403NTG2YOL043CverifiedDNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involvedin base excision repair, localizes to thenucleus 1e-050.00136 S000003518BIO2YGR286CverifiedBiotin synthase, catalyzes the conversion of dethiobiotin tobiotin, which is the last step of the biotinbiosynthesis pathway; complements E. coli bioBmutant 1e-050.00136 S000001510YKL027WVerifiedProtein of unknown function, localized to the mitochondrial outer membrane 1e-050.00136 S000002294RDI1YDL135CverifiedRho GDP dissociation inhibitor involved in the localization andregulation of Cdc42p 1e-050.00136 S000003398KRE11YGR166WverifiedProtein involved in biosynthesis of cell wall beta-glucans;subunit of the TRAPP (transport proteinparticle) complex, which is involved in thelate steps of endoplasmic reticulum to Golgitransport 1e-050.00136 S000003966FPS1YLL043WverifiedPlasma membrane glycerol channel, member of the major intrinsicprotein (MIP) family of channel proteins;involved in efflux of glycerol and in uptake ofthe trivalent metalloids arsenite andantimonite 1e-050.00136 S000007526YOR396WUncharacterizedHypothetical protein 1e-050.00136 S000005797FSF1YOR271CuncharacterizedPutative protein, predicted by computational methods to be analpha-isopropylmalate carrier; the authentic,non-tagged protein is detected in highlypurified mitochondria in high-throughputstudies 1e-050.00136 S000005119NOP13YNL175CverifiedProtein of unknown function, localizes to the nucleolus andnucleoplasm; contains an RNA recognition motif(RRM) and has similarity to Nop12p, which isrequired for processing of pre-18S rRNA 1e-050.00136 S000001644YKL161CVerifiedProtein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; associates with Rlm1p 1e-050.00136 S000006099CBC2YPL178WverifiedSmall subunit of the heterodimeric cap binding complex thatalso contains Sto1p, component of thespliceosomal commitment complex; interacts withNpl3p, possibly to package mRNA for export fromthe nucleus; contains an RNA-binding motif 1e-050.00136 S000002402AAD4YDL243CverifiedPutative aryl-alcohol dehydrogenase with similarity to P.chrysosporium aryl-alcohol dehydrogenase,involved in the oxidative stress response 1e-050.00136 S000003134CUP2YGL166WverifiedCopper-binding transcription factor; activates transcription ofthe metallothionein genes CUP1-1 and CUP1-2 inresponse to elevated copper concentrations 1e-050.00136 S000002432RPS11AYDR025WverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps11Bp and has similarity to E.coli S17 and rat S11 ribosomal proteins 1e-050.00136 S000004737YMR130WUncharacterizedHypothetical protein 1e-050.00136 S000003312TWF1YGR080WverifiedTwinfilin, highly conserved actin monomer-sequestering proteininvolved in regulation of the cortical actincytoskeleton, composed of two cofilin-likeregions, localizes actin monomers to sites ofrapid filament assembly 1e-050.00136 S000001472MGA2YIR033WverifiedER membrane protein involved in regulation of OLE1transcription, acts with homolog Spt23p;inactive ER form dimerizes and one subunit isthen activated byubiquitin/proteasome-dependent processingfollowed by nuclear targeting 1e-050.00136 S000004051RPL22AYLR061WverifiedProtein component of the large (60S) ribosomal subunit, hassimilarity to Rpl22Bp and to rat L22 ribosomalprotein 1e-050.00136 S000004456YLR464WUncharacterizedPutative protein of unknown function with similarity to helicases; YLR464W contains an intron and overlaps the verified gene YRF1-4/YLR466W and two dubious ORFs YLR463C and YLR465C 1e-050.00136 S000001100MED6YHR058CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation 1e-050.00136 S000003195YGL226WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion 1e-050.00136 S000001504MAK11YKL021CverifiedProtein essential for cell growth and replication of M dsRNAvirus; contains four beta-transducin repeats 1e-050.00136 S000005551HST3YOR025WverifiedMember of the Sir2 family of NAD(+)-dependent proteindeacetylases; involved along with Hst4p intelomeric silencing, cell cycle progression,radiation resistance, genomic stability andshort-chain fatty acid metabolism 1e-050.00136 S000003863VPS25YJR102CverifiedComponent of the ESCRT-II complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome 1e-050.00136 S000006382PRP4YPR178WverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 1e-050.00136 S000005074CPT1YNL130CverifiedCholinephosphotransferase, required for phosphatidylcholinebiosynthesis and for inositol-dependentregulation of EPT1 transcription 1e-050.00136 S000006020FMP14YPL099CuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 1e-050.00136 S000002197PRM7YDL039CverifiedPheromone-regulated protein, predicted to have onetransmembrane segment; promoter contains Gcn4pbinding elements 1e-050.00136 S000001115OSH3YHR073WverifiedMember of an oxysterol-binding protein family with sevenmembers in S. cerevisiae; family members haveoverlapping, redundant functions in sterolmetabolism and collectively perform a functionessential for viability 1e-050.00136 S000000844MXR1YER042WverifiedPeptide methionine sulfoxide reductase, reverses the oxidationof methionine residues; involved in oxidativedamage repair, providing resistance tooxidative stress and regulation of lifespan 1e-050.00136 S000000835ZRG8YER033CverifiedProtein of unknown function; authentic, non-tagged protein isdetected in highly purified mitochondria inhigh-throughput studies; GFP-fusion protein islocalized to the cytoplasm; transcriptioninduced under conditions of zinc deficiency 1e-050.00136 S000005134YNL190WUncharacterizedHypothetical protein 1e-050.00136 S000005284CIT1YNR001CverifiedCitrate synthase, catalyzes the condensation of acetyl coenzymeA and oxaloacetate to form citrate; therate-limiting enzyme of the TCA cycle; nuclearencoded mitochondrial protein 1e-050.00136 S000005070SPC98YNL126WverifiedComponent of the microtubule-nucleating Tub4p (gamma-tubulin)complex; interacts with Spc110p at the spindlepole body (SPB) inner plaque and with Spc72p atthe SPB outer plaque 1e-050.00136 S000003938BPT1YLL015WverifiedABC type transmembrane transporter of MRP/CFTR family, found invacuolar membrane, involved in the transport ofunconjugated bilirubin and in heavy metaldetoxification via glutathione conjugates,along with Ycf1p 1e-050.00136 S000005096YNL152WUncharacterizedProtein required for cell viability 1e-050.00136 S000001003PRS3YHL011Cverified5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involvedin nucleotide, histidine, and tryptophanbiosynthesis; one of a five related enzymes,which are active as heteromultimeric complexes 1e-050.00136 S000002395PHO13YDL236WverifiedAlkaline phosphatase specific for p-nitrophenyl phosphate,involved in dephosphorylation of histone II-Aand casein 1e-050.00136 S000002796RVS167YDR388WverifiedActin-associated protein, subunit of a complex(Rvs161p-Rvs167p) involved in regulation ofactin cytoskeleton, endocytosis, and viabilityfollowing starvation or osmotic stress; homologof mammalian amphiphysin 1e-050.00136 S000001455YIR016WUncharacterizedPutative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR016W is a non-essential gene 1e-050.00136 S000004746CIN4YMR138WverifiedGTP-binding protein involved in beta-tubulin (Tub2p) folding;isolated as mutant with increased chromosomeloss and sensitivity to benomyl 1e-050.00136 S000003049YGL081WUncharacterizedHypothetical protein 1e-050.00136 S000004203CRR1YLR213CverifiedPutative glycoside hydrolase of the spore wall envelope;required for normal spore wall assembly,possibly for cross-linking between the glucanand chitosan layers; expressed duringsporulation 1e-050.00136 S000000477UBX7YBR273CuncharacterizedUBX (ubiquitin regulatory X) domain-containing protein thatinteracts with Cdc48p 1e-050.00136 S000004612YMR010WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1 1e-050.00136 S000000111ACH1YBL015WverifiedAcetyl-coA hydrolase, primarily localized to mitochondria;required for acetate utilization and fordiploid pseudohyphal growth 1e-050.00136 S000003046DBP3YGL078CverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in ribosomal biogenesis 1e-050.00136 S000002288RPP1BYDL130WverifiedRibosomal protein P1 beta, component of the ribosomal stalk,which is involved in interaction oftranslational elongation factors with ribosome;accumulation is regulated by phosphorylationand interaction with the P2 stalk component 1e-050.00136 S000007243MDM35YKL053C-AverifiedMitochondrial intermembrane space cysteine motif protein;mutation affects mitochondrial distribution andmorphology 1e-050.00136 S000004258SEC22YLR268WverifiedR-SNARE protein; assembles into SNARE complex with Bet1p, Bos1pand Sed5p; cycles between the ER and Golgicomplex; involved in anterograde and retrogradetransport between the ER and Golgi;synaptobrevin homolog 1e-050.00136 S000001044LEU5YHR002WverifiedMitochondrial carrier protein involved in the accumulation ofCoA in the mitochondrial matrix; homolog ofhuman Graves disease protein; does not encodean isozyme of Leu4p, as first hypothesized 1e-050.00136 S000002973COG7YGL005CverifiedComponent of the conserved oligomeric Golgi complex (Cog1pthrough Cog8p), a cytosolic tethering complexthat functions in protein trafficking tomediate fusion of transport vesicles to Golgicompartments 1e-050.00136 S000004602YML133CUncharacterizedPutative protein of unknown function with similarity to helicases; localized to mitochondria; YML133C contains an intron 1e-050.00136 S000000874VTC1YER072WverifiedVacuolar transporter chaperon (VTC) involved in distributingV-ATPase and other membrane proteins; togetherwith other VTC proteins, forms aheterotetrameric complex that associates withthe SNARE Nyv1p and the V0 sector of theV-ATPase 1e-050.00136 S000005196MRPL17YNL252CverifiedMitochondrial ribosomal protein of the large subunit 1e-050.00136 S000007624YNL162W-AUncharacterizedHypothetical protein identified by homology. See FEBS Letters [2000] 487:31-36. 1e-050.00136 S000003663SPT10YJL127CverifiedPutative histone acetylase, sequence-specific activator ofhistone genes, binds specifically and highlycooperatively to pairs of UAS elements in corehistone promoters, functions at or near theTATA box 1e-050.00136 S000003812OSM1YJR051WverifiedFumarate reductase, catalyzes the reduction of fumarate tosuccinate, required for the reoxidation ofintracellular NADH under anaerobic conditions;mutations cause osmotic sensitivity 1e-050.00136 S000001152ERP5YHR110WverifiedProtein with similarity to Emp24p and Erv25p, member of the p24family involved in ER to Golgi transport 1e-050.00136 S000002358YDL199CUncharacterizedPutative protein of unknown function with sequence similarity to members of the sugar permease family 1e-050.00136 S000003356ASN2YGR124WverifiedAsparagine synthetase, isozyme of Asn1p; catalyzes thesynthesis of L-asparagine from L-aspartate inthe asparagine biosynthetic pathway 1e-050.00136 S000000186MRP21YBL090WverifiedMitochondrial ribosomal protein of the large subunit; MRP21exhibits genetic interactions with mutations inthe COX2 and COX3 mRNA 5'-untranslated leadersequences 1e-050.00136 S000003878STE24YJR117WverifiedHighly conserved zinc metalloprotease that functions in twosteps of a-factor maturation, C-terminal CAAXproteolysis and the first step of N-terminalproteolytic processing; contains multipletransmembrane spans 1e-050.00136 S000004763RIM13YMR154CverifiedCalpain-like protease involved in proteolytic activation ofRim101p in response to alkaline pH; hassimilarity to A. nidulans palB 1e-050.00136 S000000498SUL1YBR294WverifiedHigh affinity sulfate permease; sulfate uptake is mediated byspecific sulfate transporters Sul1p and Sul2p,which control the concentration of endogenousactivated sulfate intermediates 1e-050.00136 S000005629OST2YOR103CverifiedEpsilon subunit of the oligosaccharyltransferase complex of theER lumen, which catalyzes asparagine-linkedglycosylation of newly synthesized proteins 1e-050.00136 S000005163ALG9YNL219CverifiedMannosyltransferase, involved in N-linked glycosylation;catalyzes the transfer of mannose fromDol-P-Man to lipid-linked oligosaccharides;mutation of the human ortholog causes type 1congenital disorders of glycosylation 1e-050.00136 S000000059FLO9YAL063CverifiedLectin-like protein with similarity to Flo1p, thought to beexpressed and involved in flocculation 1e-050.00136 S000001489RPL14AYKL006WverifiedN-terminally acetylated protein component of the large (60S)ribosomal subunit, nearly identical to Rpl14Bpand has similarity to rat L14 ribosomalprotein; rpl14a csh5 double null mutantexhibits synthetic slow growth 1e-050.00136 S000000788NPR2YEL062WverifiedProtein with a possible role in regulating expression ofnitrogen permeases; transcription is induced inresponse to proline and urea; contains two PESTsequences; null mutant is resistant tocisplatin and doxorubicin 1e-050.00136 S000001543FBA1YKL060CverifiedFructose 1,6-bisphosphate aldolase, required for glycolysis andgluconeogenesis; catalyzes conversion offructose 1,6 bisphosphate to glyceraldehyde-3-Pand dihydroxyacetone-P; locates tomitochondrial outer surface upon oxidativestress 1e-050.00136 S000002504MSH6YDR097CverifiedProtein required for mismatch repair in mitosis and meiosis,forms a complex with Msh2p to repair bothsingle-base & insertion-deletion mispairs;potentially phosphorylated by Cdc28p 1e-050.00136 S000000769YEL043WUncharacterizedPredicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; contains fibronectin type III domain fold 1e-050.00136 S000003564YJL027CUncharacterizedHypothetical protein 1e-050.00136 S000003230PAU11YGL261CuncharacterizedPutative protein of unknown function; mRNA expression appearsto be regulated by SUT1 and UPC2 1e-050.00136 S000005815YOR289WUncharacterizedHypothetical protein 1e-050.00136 S000001402AXL2YIL140WverifiedIntegral plasma membrane protein required for axial budding inhaploid cells, localizes to the incipient budsite and bud neck; glycosylated by Pmt4p;potential Cdc28p substrate 1e-050.00136 S000005350DSE4YNR067CverifiedDaughter cell-specific secreted protein with similarity toglucanases, degrades cell wall from thedaughter side causing daughter to separate frommother 1e-050.00136 S000003774GPI14YJR013WuncharacterizedGlycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I,involved in GPI anchor biosynthesis, requiresPbn1p for function; homolog of mammalian PIG-M 1e-050.00136 S000006304MRPL51YPR100WverifiedMitochondrial ribosomal protein of the large subunit 1e-050.00136 S000028584YOR316C-AUncharacterizedIdentified by fungal homology and RT-PCR 1e-050.00136 S000001414YIL152WUncharacterizedHypothetical protein 1e-050.00136 S000005473SKM1YOL113WverifiedMember of the PAK family of serine/threonine protein kinaseswith similarity to Ste20p and Cla4p; proposedto be a downstream effector of Cdc42p duringpolarized growth 1e-050.00136 S000005369MDM12YOL009CverifiedMitochondrial outer membrane protein, required for transmissionof mitochondria to daughter cells; exists in acomplex with Mmm1p and Mdm10p 1e-050.00136 S000004271YLR281CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene 1e-050.00136 S000002443EHD3YDR036CverifiedProtein of unconfirmed function, plays an indirect role inendocytic membrane trafficking, member of afamily of enoyl-CoA hydratase/isomerases; thenon-tagged protein is detected in highlypurified mitochondria in high-throughputstudies 1e-050.00136 S000000122LSM2YBL026WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 1e-050.00136 S000004416SPP382YLR424WverifiedEssential protein that forms a dimer with Ntr2p; also forms atrimer, with Ntr2p and Prp43p, that is involvedin spliceosome disassembly; found also in amultisubunit complex with the splicing factorClf1p; suppressor of prp38-1 mutation 1e-050.00136 S000004657STB2YMR053CverifiedProtein that interacts with Sin3p in a two-hybrid assay and ispart of a large protein complex with Sin3p andStb1p 1e-050.00136 S000004778CEP3YMR168CverifiedEssential kinetochore protein, component of the CBF3 complexthat binds the CDEIII region of the centromere;contains an N-terminal Zn2Cys6 type zinc fingerdomain, a C-terminal acidic domain, and aputative coiled coil dimerization domain 1e-050.00136 S000003237TFG2YGR005CverifiedTFIIF (Transcription Factor II) middle subunit; involved inboth transcription initiation and elongation ofRNA polymerase II; homologous to human RAP30 1e-050.00136 S000001155YHR113WVerifiedCytoplasmic aspartyl aminopeptidase; cleaves unblocked N-terminal acidic amino acid residues from peptide substrates; forms a 12 subunit homo-oligomeric complex; inhibited by EDTA and 1,10-phenanthroline; M18 metalloprotease family member 1e-050.00136 S000002420PSF1YDR013WverifiedSubunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), whichis localized to DNA replication origins andimplicated in assembly of the DNA replicationmachinery 1e-050.00136 S000005519YOL159CUncharacterizedHypothetical protein 1e-050.00136 S000001215SPC97YHR172WverifiedComponent of the microtubule-nucleating Tub4p (gamma-tubulin)complex; interacts with Spc110p at the spindlepole body (SPB) inner plaque and with Spc72p atthe SPB outer plaque 1e-050.00136 S000000991YER189WUncharacterizedHypothetical protein 1e-050.00136 S000000070ADE1YAR015WverifiedN-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR)synthetase, required for 'de novo' purinenucleotide biosynthesis; red pigmentaccumulates in mutant cells deprived of adenine 1e-050.00136 S000005904ATF1YOR377WverifiedAlcohol acetyltransferase with potential roles in lipid andsterol metabolism; responsible for the majorpart of volatile acetate ester productionduring fermentation 1e-050.00136 S000001952IRC7YFR055WuncharacterizedPutative cystathionine beta-lyase; involved in copper ionhomeostasis and sulfur metabolism; null mutantdisplays increased levels of spontaneous Rad52foci 1e-050.00136 S000006059SPP1YPL138CverifiedSubunit of COMPASS (Set1C), a complex which methylates histoneH3 on lysine 4 and is required in telomerictranscriptional silencing; PHD finger domainprotein similar to human CGBP, an unmethylatedCpG binding protein 1e-050.00136 S000004497SRC1YML034WverifiedProtein with a putative role in sister chromatid segregation,potentially phosphorylated by Cdc28p; greenfluorescent protein (GFP)-fusion proteinlocalizes to the nuclear periphery 1e-050.00136 S000000131POL12YBL035CverifiedB subunit of DNA polymerase alpha-primase complex, required forinitiation of DNA replication during mitoticand premeiotic DNA synthesis; also functions intelomere capping and length regulation 1e-050.00136 S000002880TRS31YDR472WverifiedOne of 10 subunits of the transport protein particle (TRAPP)complex of the cis-Golgi which mediates vesicledocking and fusion; involved in endoplasmicreticulum (ER) to Golgi membrane traffic 1e-050.00136 S000003968RPL8BYLL045CverifiedRibosomal protein L4 of the large (60S) ribosomal subunit,nearly identical to Rpl8Ap and has similarityto rat L7a ribosomal protein; mutation resultsin decreased amounts of free 60S subunits 1e-050.00136 S000000611SRD1YCR018CverifiedProtein involved in the processing of pre-rRNA to mature rRNA;contains a C2/C2 zinc finger motif; srd1mutation suppresses defects caused by therrp1-1 mutation 1e-050.00136 S000001523NFU1YKL040CverifiedProtein involved in iron metabolism in mitochondria; similar toNifU, which is a protein required for thematuration of the Fe/S clusters of nitrogenasein nitrogen-fixing bacteria 1e-050.00136 S000000868YER066WUncharacterizedHypothetical protein 1e-050.00136 S000004425CNA1YLR433CverifiedCalcineurin A; one isoform (the other is CMP2) of the catalyticsubunit of calcineurin, aCa++/calmodulin-regulated protein phosphatasewhich regulates Crz1p (a stress-responsetranscription factor), the other calcineurinsubunit is CNB1 1e-050.00136 S000002784ARH1YDR376WverifiedOxidoreductase of the mitochondrial inner membrane, involved incytoplasmic and mitochondrial iron homeostasisand required for activity of Fe-Scluster-containing enzymes; one of the fewmitochondrial proteins essential for viability 1e-050.00136 S000005314SSK2YNR031CverifiedMAP kinase kinase kinase of the HOG1 mitogen-activatedsignaling pathway; interacts with Ssk1p,leading to autophosphorylation and activationof Ssk2p which phosphorylates Pbs2p; alsomediates actin cytoskeleton recovery fromosmotic stress 1e-050.00136 S000002523MRPL1YDR116CverifiedMitochondrial ribosomal protein of the large subunit 1e-050.00136 S000002222UBC9YDL064WverifiedSUMO-conjugating enzyme involved in the Smt3p conjugationpathway; nuclear protein required for S- andM-phase cyclin degradation and mitotic control;involved in proteolysis mediated by theanaphase-promoting complex cyclosome (APCC) 1e-050.00136 S000002378DTD1YDL219WverifiedD-Tyr-tRNA(Tyr) deacylase, functions in protein translation,may affect nonsense suppression via alterationof the protein synthesis machinery; ubiquitousamong eukaryotes 1e-050.00136 S000000421ATG12YBR217WverifiedUbiquitin-like modifier, conjugated via an isopeptide bond to alysine residue of Atg5p by the E1 enzyme,Atg7p, and the E2 enzyme, Atg10p, a step thatis essential for autophagy 1e-050.00136 S000004109SRN2YLR119WverifiedComponent of the ESCRT-I complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; suppressor of rna1-1 mutation;may be involved in RNA export from nucleus 1e-050.00136 S000004863GTO3YMR251WuncharacterizedOmega class glutathione transferase; putative cytosoliclocalization 1e-050.00136 S000002278YFH1YDL120WverifiedFrataxin, regulates mitochondrial iron accumulation; interactswith Isu1p which promotes Fe-S clusterassembly; interacts with electron transportchain components and may influence respiration;human homolog involved in Friedrich's ataxia 1e-050.00136 S000000026FRT2YAL028WverifiedTail-anchored endoplasmic reticulum membrane protein, interactswith homolog Frt1p but is not a substrate ofcalcineurin (unlike Frt1p), promotes growth inconditions of high Na+, alkaline pH, or cellwall stress; potential Cdc28p substrate 1e-050.00136 S000006030YPL109CUncharacterizedHypothetical protein 1e-050.00136 S000002351ARF1YDL192WverifiedADP-ribosylation factor, GTPase of the Ras superfamily involvedin regulation of coated formation vesicles inintracellular trafficking within the Golgi;functionally interchangeable with Arf2p 1e-050.00136 S000001840YFL054CUncharacterizedPutative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol 1e-050.00136 S000002609SPC19YDR201WverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; also localized tonuclear side of spindle pole body 1e-050.00136 S000002683BSC2YDR275WverifiedProtein of unknown function, ORF exhibits genomic organizationcompatible with a translationalreadthrough-dependent mode of expression 1e-050.00136 S000005006GCD10YNL062CverifiedSubunit of tRNA (1-methyladenosine) methyltransferase withGcd14p, required for the modification of theadenine at position 58 in tRNAs, especiallytRNAi-Met; first identified as a negativeregulator of GCN4 expression 1e-050.00136 S000003647CCT7YJL111WverifiedSubunit of the cytosolic chaperonin Cct ring complex, relatedto Tcp1p, required for the assembly of actinand tubulins in vivo 1e-050.00136 S000003291SPR3YGR059WverifiedSporulation-specific homolog of the yeast CDC3/10/11/12 familyof bud neck microfilament genes; septin proteininvolved in sporulation; regulated by ABFI 1e-050.00136 S000002438MIC14YDR031WverifiedMitochondrial intermembrane space cysteine motif protein of 14kDa 1e-050.00136 S000003005PNC1YGL037CverifiedNicotinamidase that converts nicotinamide to nicotinic acid aspart of the NAD(+) salvage pathway, requiredfor life span extension by calorie restriction;PNC1 expression responds to all known stimulithat extend replicative life span 1e-050.00136 S000003325YGR093WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus 1e-050.00136 S000001808SKG1YKR100CuncharacterizedTransmembrane protein of unknown function; localizes on theinner surface of the plasma membrane at the budand in the daughter cell; affects the cell wallpolymer composition 1e-050.00136 S000000802YEL076CUncharacterizedHypothetical protein 1e-050.00136 S000003099SNT2YGL131CverifiedDNA binding protein with similarity to the S. pombe Snt2protein 1e-050.00136 S000006409YEL077CUncharacterizedHelicase-like protein encoded within the telomeric Y' element 1e-050.00136 S000002270TRM3YDL112Wverified2'-O-ribose methyltransferase, catalyzes the ribose methylationof the guanosine nucleotide at position 18 oftRNAs 1e-050.00136 S000002717GIC2YDR309CverifiedProtein of unknown function involved in initiation of buddingand cellular polarization, interacts withCdc42p via the Cdc42/Rac-interactive binding(CRIB) domain 1e-050.00136 S000002822ERD1YDR414CverifiedPredicted membrane protein required for the retention oflumenal endoplasmic reticulum proteins; mutantssecrete the endogenous ER protein, BiP (Kar2p) 1e-050.00136 S000006191MDL2YPL270WverifiedHalf-type ATP-binding cassette (ABC) transporter of the innermitochondrial membrane 1e-050.00136 S000005953SVL3YPL032CverifiedProtein of unknown function, mutant phenotype suggests apotential role in vacuolar function; greenfluorescent protein (GFP)-fusion proteinlocalizes to the cell periphery, cytoplasm,bud, and bud neck 1e-050.00136 S000001045YHR003CVerifiedProtein of unknown function, localized to the mitochondrial outer membrane 1e-050.00136 S000002938APA2YDR530CverifiedDiadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4Aphosphorylase), involved in catabolism ofbis(5'-nucleosidyl) tetraphosphates; hassimilarity to Apa1p 1e-050.00136 S000005152YNL208WUncharacterizedHypothetical protein 1e-050.00136 S000005985CWC27YPL064CverifiedComponent of a complex containing Cef1p, putatively involved inpre-mRNA splicing; has similarity to S. pombeCwf27p 1e-050.00136 S000005297YNR014WUncharacterizedHypothetical protein 1e-050.00136 S000001318VHR1YIL056WuncharacterizedTranscriptional activator, required for the vitaminH-responsive element (VHRE) mediated inductionof VHT1 (Vitamin H transporter) and BIO5(biotin biosynthesis intermediate transporter)in response to low biotin concentrations 1e-050.00136 S000005355HXT17YNR072WverifiedHexose transporter, up-regulated in media containing raffinoseand galactose at pH 7.7 versus pH 4.7,repressed by high levels of glucose 1e-050.00136 S000003192SDT1YGL224CverifiedPyrimidine nucleotidase; overexpression suppresses the 6-AUsensitivity of transcription elongation factorS-II, as well as resistance to other pyrimidinederivatives 1e-050.00136 S000005425MET22YOL064CverifiedBisphosphate-3'-nucleotidase, involved in salt tolerance andmethionine biogenesis; dephosphorylates3'-phosphoadenosine-5'-phosphate and3'-phosphoadenosine-5'-phosphosulfate,intermediates of the sulfate assimilationpathway 1e-050.00136 S000006149CET1YPL228WverifiedBeta (RNA 5'-triphosphatase) subunit of the mRNA cappingenzyme, a heterodimer (the other subunit isCEG1, a guanylyltransferase) involved in addingthe 5' cap to mRNA; the mammalian enzyme is asingle bifunctional polypeptide 1e-050.00136 S000005500ARG8YOL140WverifiedAcetylornithine aminotransferase, catalyzes the fourth step inthe biosynthesis of the arginine precursorornithine 1e-050.00136 S000005357AIF1YNR074CverifiedMitochondrial cell death effector that translocates to thenucleus in response to apoptotic stimuli,homolog of mammalian Apoptosis-Inducing Factor,putative reductase 1e-050.00136 S000002813MRP20YDR405WverifiedMitochondrial ribosomal protein of the large subunit 1e-050.00136 S000001347KTR7YIL085CverifiedPutative mannosyltransferase involved in protein glycosylation;member of the KRE2/MNT1 mannosyltransferasefamily 1e-050.00136 S000005859VMA4YOR332WverifiedSubunit E of the eight-subunit V1 peripheral membrane domain ofthe vacuolar H+-ATPase (V-ATPase), anelectrogenic proton pump found throughout theendomembrane system; required for the V1 domainto assemble onto the vacuolar membrane 1e-050.00136 S000000775PAU2YEL049WverifiedPart of 23-member seripauperin multigene family encoded mainlyin subtelomeric regions, active duringalcoholic fermentation, regulated byanaerobiosis, negatively regulated by oxygen,repressed by heme 1e-050.00136 S000005770ESA1YOR244WverifiedHistone acetyltransferase catalytic subunit of the nativemultisubunit complex (NuA4) that acetylatesfour conserved internal lysines of histone H4N-terminal tail; required for cell cycleprogression 1e-050.00136 S000005257YNL313CUncharacterizedProtein required for cell viability 1e-050.00136 S000001408ECM37YIL146CverifiedNon-essential protein of unknown function 1e-050.00136 S000001539TMA19YKL056CverifiedProtein that associates with ribosomes; homolog oftranslationally controlled tumor protein; greenfluorescent protein (GFP)-fusion proteinlocalizes to the cytoplasm and relocates to themitochondrial outer surface upon oxidativestress 1e-050.00136 S000002491TVP23YDR084CuncharacterizedIntegral membrane protein localized to late Golgi vesiclesalong with the v-SNARE Tlg2p; green fluorescentprotein (GFP)-fusion protein localizes to thecytoplasm in a punctate pattern 1e-050.00136 S000004686ISF1YMR081CverifiedSerine-rich, hydrophilic protein with similarity to Mbr1p;overexpression suppresses growth defects ofhap2, hap3, and hap4 mutants; expression isunder glucose control; cotranscribed with NAM7in a cyp1 mutant 1e-050.00136 S000001669MTR2YKL186CverifiedmRNA transport regulator, essential nuclear protein; Mex67p andMtr2p form a mRNA export complex which binds toRNA 1e-050.00136 S000028849YMR247W-AUncharacterizedPutative protein of unknown function 1e-050.00136 S000028580YOL164W-AUncharacterizedIdentified by fungal homology and RT-PCR 1e-050.00136 S000001265CFD1YIL003WverifiedHighly conserved, putative P-loop ATPase localized in thecytoplasm; has a potential role in assembly ofiron-sulfur clusters in proteins 1e-050.00136 S000002449YDR042CUncharacterizedHypothetical protein 1e-050.00136 S000001466DAL1YIR027CverifiedAllantoinase, converts allantoin to allantoate in the firststep of allantoin degradation; expressionsensitive to nitrogen catabolite repression 1e-050.00136 S000005169CNM67YNL225CverifiedComponent of the spindle pole body outer plaque; required forspindle orientation and mitotic nuclearmigration 1e-050.00136 S000001922YFR026CUncharacterizedHypothetical protein 1e-050.00136 S000003244YGR012WVerifiedPutative cysteine synthase, localized to the mitochondrial outer membrane 1e-050.00136 S000000291RFC5YBR087WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon 1e-050.00136 S000003563RNR2YJL026WverifiedRibonucleotide-diphosphate reductase (RNR), small subunit; theRNR complex catalyzes the rate-limiting step indNTP synthesis and is regulated by DNAreplication and DNA damage checkpoint pathwaysvia localization of the small subunits 1e-050.00136 S000003247YGR015CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion