Yfunc lets you browse current and predicted gene functions in yeast

Enter a GO term ID (example: GO:0003723):
Enter a yeast gene name to browse (example:AIR1):

Prediction of GO:0006378 "mRNA polyadenylation"

GO branch: BP
Number of currently annotated genes: 18

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest Kumar:nucleusTAP:162Huh:nucleusTAP:111Lum:DaunorubicinLum:ClomipramineLum:TrifluoperazineIPR000504Lum:IbuprofenPF05843 S000003388PTI1YGR156WverifiedPta1p Interacting protein &radic0.384130.92364&radic&radic&radic&radic&radic&radic&radic&radic&radic S000004105CFT2YLR115WverifiedSubunit of the mRNA cleavage and polyadenlylation factor (CPF);required for pre-mRNA cleavage, polyadenylationand poly(A) site recognition, 43% similaritywith the mammalian CPSF-100 protein. &radic0.389860.92364&radic&radic&radic&radic&radic&radic&radic&radic S000004267YSH1YLR277CverifiedPutative endonuclease, subunit of the mRNA cleavage andpolyadenylation specificity complex requiredfor 3' processing of mRNAs &radic0.362560.9106&radic&radic&radic&radic&radic&radic&radic S000005166SSU72YNL222WverifiedTranscription/RNA-processing factor that associates with TFIIBand cleavage/polyadenylation factor Pta1p;exhibits phosphatase activity on serine-5 ofthe RNA polymerase II C-terminal domain;affects start site selection in vivo 0.354220.89757&radic&radic&radic&radic&radic S000000041PTA1YAL043CverifiedSubunit of holo-CPF, a multiprotein complex and functionalhomolog of mammalian CPSF, required for thecleavage and polyadenylation of mRNA and snoRNA3' ends; involved in pre-tRNA processing; bindsto the phosphorylated CTD of RNAPII &radic0.354890.89757&radic&radic&radic&radic&radic&radic&radic&radic S000000935GLC7YER133WverifiedCatalytic subunit of type 1 serine/threonine proteinphosphatase, involved in many processesincluding glycogen metabolism, sporulation, andmitosis; interacts with multiple regulatorysubunits; predominantly isolated with Sds22p 0.317050.85556&radic&radic&radic S000005261PFS2YNL317WverifiedIntegral subunit of the pre-mRNA cleavage and polyadenylationfactor (CPF) complex; plays an essential rolein mRNA 3'-end formation by bridging differentprocessing factors and thereby promoting theassembly of the processing complex &radic0.311340.8547&radic&radic&radic&radic&radic&radic S000003853FIP1YJR093CverifiedSubunit of cleavage polyadenylation factor (CPF), interactsdirectly with poly(A) polymerase (Pap1p) toregulate its activity &radic0.308630.85207&radic&radic&radic S000002636PCF11YDR228CverifiedmRNA 3' end processing factor, essential component of cleavageand polyadenylation factor IA (CF IA), involvedin pre-mRNA 3' end processing and intranscription termination; binds C-terminaldomain of largest subunit of RNA pol II(Rpo21p) &radic0.297460.83778&radic&radic&radic&radic&radic S000004665RNA14YMR061WverifiedCleavage and polyadenylation factor I (CF I) component involvedin cleavage and polyadenylation of mRNA 3'ends; bridges interaction between Rna15p andHrp1p in the CF I complex &radic0.257590.8079&radic&radic&radic&radic S000002603REF2YDR195WverifiedRNA-binding protein involved in the cleavage step of mRNA3'-end formation prior to polyadenylation, andin snoRNA maturation; part of holo-CPFsubcomplex APT, which associates with 3'-endsof snoRNA- and mRNA-encoding genes 0.239590.79958&radic&radic&radic&radic&radic S000002709CFT1YDR301WverifiedRNA-binding subunit of the mRNA cleavage and polyadenylationfactor; involved in poly(A) site recognitionand required for both pre-mRNA cleavage andpolyadenylation, 51% sequence similarity withmammalian AAUAA-binding subunit of CPSF &radic0.229070.78691&radic&radic&radic&radic&radic S000003012RNA15YGL044CverifiedCleavage and polyadenylation factor I (CF I) component involvedin cleavage and polyadenylation of mRNA 3'ends; interacts with the A-rich polyadenylationsignal in complex with Rna14p and Hrp1p &radic0.210340.76551&radic&radic&radic S000006311YTH1YPR107CverifiedEssential RNA-binding component of cleavage and polyadenylationfactor, contains five zinc fingers; requiredfor pre-mRNA 3'-end processing andpolyadenylation &radic0.210070.76551&radic&radic&radic&radic&radic S000005705SYC1YOR179CverifiedSubunit of the APT subcomplex of cleavage and polyadenylationfactor, may have a role in 3' end formation ofboth polyadenylated and non-polyadenylated RNAs 0.177740.74095&radic&radic&radic&radic S000005776CLP1YOR250CverifiedSubunit of cleavage factor I (CFI), involved in both theendonucleolyitc cleavage and polyadenylationsteps of mRNA 3'-end maturation &radic0.154340.70617&radic&radic&radic&radic&radic S000001542MPE1YKL059CverifiedEssential conserved subunit of CPF (cleavage andpolyadenylation factor), plays a role in 3' endformation of mRNA via the specific cleavage andpolyadenylation of pre-mRNA, contains aputative RNA-binding zinc knuckle motif &radic0.124090.66477&radic&radic&radic&radic&radic S000000221KAP104YBR017CverifiedTransportin, cytosolic karyopherin beta 2 involved in deliveryof heterogeneous nuclear ribonucleoproteins tothe nucleoplasm, binds rg-nuclear localizationsignals on Nab2p and Hrp1p, plays a role incell-cycle progression 0.123940.66477&radic S000000551YCL046WDubiousHypothetical protein 0.117960.65249&radic&radic&radic S000001855ACT1YFL039CverifiedActin, structural protein involved in cell polarization,endocytosis, and other cytoskeletal functions 0.099440.61668&radic&radic S000001297CKA1YIL035CverifiedAlpha catalytic subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA2, CKB1 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.063350.53953&radic&radic&radic&radic S000003017TIF4632YGL049CverifiedTranslation initiation factor eIF4G, subunit of the mRNAcap-binding protein complex (eIF4F) that alsocontains eIF4E (Cdc33p); associates with thepoly(A)-binding protein Pab1p, also interactswith eIF4A (Tif1p); homologous to Tif4631p 0.063290.53953&radic&radic&radic&radic S000004975HHF2YNL030WverifiedOne of two identical histone H4 proteins (see also HHF1); corehistone required for chromatin assembly andchromosome function; contributes to telomericsilencing; N-terminal domain involved inmaintaining genomic integrity 0.055150.51274&radic&radic&radic S000004198SEC13YLR208WverifiedComponent of both the Nup84 nuclear pore sub-complex and of theCOPII complex (Sar1p, Sec13p, Sec16p, Sec23p,Sec24p, Sec31p, Sfb2p, and Sfb3p) which isimportant for the formation of ER to Golgitransport vesicles 0.054580.51088&radic&radic&radic&radic S000005871TYE7YOR344CverifiedSerine-rich protein that contains a basic-helix-loop-helix(bHLH) DNA binding motif; binds E-boxes ofglycolytic genes and contributes to theiractivation; may function as a transcriptionalactivator in Ty1-mediated gene expression 0.05230.50243&radic&radic&radic&radic S000000967PAB1YER165WverifiedPoly(A) binding protein, part of the 3'-end RNA-processingcomplex, mediates interactions between the 5'cap structure and the 3' mRNA poly(A) tail,involved in control of poly(A) tail length,interacts with translation factor eIF-4G 0.045840.47296&radic&radic S000003472PFK1YGR240CverifiedAlpha subunit of heterooctameric phosphofructokinase involvedin glycolysis, indispensable for anaerobicgrowth, activated by fructose-2,6-bisphosphateand AMP, mutation inhibits glucose induction ofcell cycle-related genes 0.04580.47296&radic&radic&radic&radic S000002633HTA1YDR225WverifiedOne of two nearly identical (see also HTA2) histone H2Asubtypes; core histone required for chromatinassembly and chromosome function; DNAdamage-dependent phosphorylation by Mec1pfacilitates DNA repair; acetylated by Nat4p 0.045460.47048&radic&radic&radic S000004492YML030WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YML030W is not an essential gene 0.044640.46498&radic&radic&radic&radic S000003080TAF6YGL112CverifiedSubunit (60 kDa) of TFIID and SAGA complexes, involved intranscription initiation of RNA polymerase IIand in chromatin modification, similar tohistone H4 0.041190.44934&radic&radic S000004211RSA3YLR221CverifiedProtein with a likely role in ribosomal maturation, requiredfor accumulation of wild-type levels of large(60S) ribosomal subunits; binds to the helicaseDbp6p in pre-60S ribosomal particles in thenucleolus 0.040550.44607&radic S000000309VID24YBR105CverifiedPeripheral membrane protein located at Vid (vacuole import anddegradation) vesicles; regulatesfructose-1,6-bisphosphatase (FBPase) targetingto the vacuole; involved inproteasome-dependent catabolite degradation ofFBPase 0.040460.4457&radic&radic S000000171SSA3YBL075CverifiedATPase involved in protein folding and the response to stress;plays a role in SRP-dependent cotranslationalprotein-membrane targeting and translocation;member of the heat shock protein 70 (HSP70)family; localized to the cytoplasm 0.036360.42254&radic&radic&radic&radic S000001027VMR1YHL035CverifiedProtein of unknown function that may interact with ribosomes,based on co-purification experiments; member ofthe ATP-binding cassette (ABC) family;potential Cdc28p substrate; detected inpurified mitochondria in high-throughputstudies 0.034610.41317&radic&radic S000003566VPS53YJL029CverifiedComponent of the GARP (Golgi-associated retrograde protein)complex, Vps51p-Vps52p-Vps53p-Vps54p, which isrequired for the recycling of proteins fromendosomes to the late Golgi; required forvacuolar protein sorting 0.033860.4093&radic S000001217ENO2YHR174WverifiedEnolase II, a phosphopyruvate hydratase that catalyzes theconversion of 2-phosphoglycerate tophosphoenolpyruvate during glycolysis and thereverse reaction during gluconeogenesis;expression is induced in response to glucose 0.032680.40277&radic S000002840NPL3YDR432WverifiedRNA-binding protein that carries poly(A)+ mRNA from the nucleusinto the cytoplasm; phosphorylation by Sky1p inthe cytoplasm may promote release of mRNAs 0.03160.39659&radic&radic&radic&radic S000002354SEC31YDL195WverifiedEssential phosphoprotein component (p150) of the COPII coat ofsecretory pathway vesicles, in complex withSec13p; required for ER-derived transportvesicle formation 0.029070.38212&radic S000001710PAP1YKR002WverifiedPoly(A) polymerase, one of three factors required for mRNA3'-end polyadenylation, forms multiproteincomplex with polyadenylation factor I (PF I),also required for mRNA nuclear export; may alsopolyadenylate rRNAs &radic0.028750.37991&radic&radic&radic&radic&radic S000003450CRM1YGR218WverifiedMajor karyopherin, involved in export of proteins, RNAs, andribosomal subunits from the nucleus 0.028280.37669&radic&radic&radic&radic S000005483HRP1YOL123WverifiedSubunit of cleavage factor I, a five-subunit complex requiredfor the cleavage and polyadenylation ofpre-mRNA 3' ends; RRM-containing heteronuclearRNA binding protein and hnRNPA/B family memberthat binds to poly (A) signal sequences &radic0.027330.37083&radic&radic&radic S000002299RPO21YDL140CverifiedRNA polymerase II largest subunit B220, part of central core;phosphorylation of C-terminal heptapeptiderepeat domain regulates association withtranscription and splicing factors; similar tobacterial beta-prime 0.025020.35477&radic&radic S000002918SMT3YDR510WverifiedUbiquitin-like protein of the SUMO family, conjugated to lysineresidues of target proteins; regulateschromatid cohesion, chromosome segregation,APC-mediated proteolysis, DNA replication andseptin ring dynamics 0.023830.34603&radic&radic S000002218TSR1YDL060WverifiedProtein required for processing of 20S pre-rRNA in thecytoplasm, associates with pre-40S ribosomalparticles 0.022260.33145&radic S000002430SES1YDR023WverifiedCytosolic seryl-tRNA synthetase, class II aminoacyl-tRNAsynthetase that aminoacylates tRNA(Ser),displays tRNA-dependent amino acid recognitionwhich enhances discrimination of the serinesubstrate, interacts with peroxin Pex21p 0.021240.322 S000002789YRA1YDR381WverifiedNuclear protein that binds to RNA and to Mex67p, required forexport of poly(A)+ mRNA from the nucleus;member of the REF (RNA and export factorbinding proteins) family; another familymember, Yra2p, can substitute for Yra1pfunction 0.020470.3142&radic&radic&radic&radic&radic&radic S000004642SUB1YMR039CverifiedTranscriptional coactivator, facilitates elongation byinfluencing enzymes that modify RNAP II, actsin a peroxide resistance pathway involvingRad2p; suppressor of TFIIB mutations 0.019450.30345&radic&radic&radic S000004895AEP2YMR282CverifiedMitochondrial protein, likely involved in translation of themitochondrial OLI1 mRNA; exhibits geneticinteraction with the OLI1 mRNA 5'-untranslatedleader 0.018570.29179&radic S000000912KAP123YER110CverifiedKaryopherin beta, mediates nuclear import of ribosomal proteinsprior to assembly into ribosomes and import ofhistones H3 and H4; localizes to the nuclearpore, nucleus, and cytoplasm; exhibits geneticinteractions with RAI1 0.017010.27261&radic&radic S000002758ATP22YDR350CverifiedMitochondrial inner membrane protein required for assembly ofthe F0 sector of mitochondrial F1F0 ATPsynthase, which is a large, evolutionarilyconserved enzyme complex required for ATPsynthesis 0.016730.26932&radic&radic&radic&radic S000002349UFD2YDL190CverifiedUbiquitin chain assembly factor (E4) that cooperates with aubiquitin-activating enzyme (E1), aubiquitin-conjugating enzyme (E2), and aubiquitin protein ligase (E3) to conjugateubiquitin to substrates; also functions as an 0.01530.24816&radic S000004513RSE1YML049CverifiedProtein involved in pre-mRNA splicing; component of thepre-spliceosome; associates with U2 snRNA;involved in ER to Golgi transport 0.014570.23854 S000002453BAP3YDR046CverifiedAmino acid permease involved in the uptake of cysteine,leucine, isoleucine and valine 0.013750.22725&radic&radic S000003279TFC4YGR047CverifiedOne of six subunits of the RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part of theTauA domain of TFIIIC that binds BoxA DNApromoter sites of tRNA and similar genes; hasTPR motifs; human homolog is TFIIIC-102 0.012570.20895&radic&radic&radic&radic&radic S000004868GFD1YMR255WverifiedCoiled-coiled protein of unknown function, identified as ahigh-copy suppressor of a dbp5 mutation 0.010380.17982&radic&radic S000002697RTT103YDR289CverifiedProtein that interacts with exonuclease Rat1p and Rai1p andplays a role in transcription termination byRNA polymerase II, has an RPR domain(carboxy-terminal domain interacting domain);also involved in regulation of Ty1transposition 0.010350.1791&radic&radic&radic&radic S000000323MUD1YBR119WverifiedU1 snRNP A protein, homolog of human U1-A; involved in nuclearmRNA splicing 0.010130.17585&radic&radic&radic S000005195NRD1YNL251CverifiedRNA-binding protein that interacts with the C-terminal domainof the RNA polymerase II large subunit(Rpo21p), required for transcriptiontermination and 3' end maturation ofnonpolyadenylated RNAs 0.010080.17562&radic&radic&radic&radic&radic&radic S000001163LSM12YHR121WverifiedProtein of unknown function that interacts with Pbp1p and Pbp4pand associates with ribosomes; contains anRNA-binding LSM domain and an AD domain; mayplay a role in RNA processing 0.009990.17429&radic&radic&radic&radic S000005527RRP6YOR001WverifiedExonuclease component of the nuclear exosome; contributes tothe quality-control system that retains anddegrades aberrant mRNAs in the nucleus 0.009880.17264&radic&radic S000005952PHO85YPL031CverifiedCyclin-dependent kinase, with ten cyclin partners; involved inenvironmental stress response; inphosphate-rich conditions, Pho85p-Pho80pcomplex phosphorylates Pho4p which in turnrepresses PHO5 0.00970.16961&radic&radic&radic&radic&radic S000002798UBA2YDR390CverifiedNuclear protein that acts as a heterodimer with Aos1p toactivate Smt3p (SUMO) before its conjugation toproteins (sumoylation), which may play a rolein protein targeting; essential for viability 0.009040.15851&radic&radic&radic&radic&radic&radic S000001803MLP1YKR095WverifiedMyosin-like protein associated with the nuclear envelope,connects the nuclear pore complex with thenuclear interior; involved with Tel1p intelomere length control; involved with Pml1pand Pml39p in nuclear retention of unsplicedmRNAs 0.008930.15684&radic S000005475PAP2YOL115WverifiedCatalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), anuclear poly (A) polymerase complex involved inRNA quality control; catalyzes polyadenylationof unmodified tRNAs, and snoRNA and rRNAprecursors; disputed role as a DNA polymerase 0.00880.15455&radic S000001341AIR1YIL079CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p to regulate methylationof Npl3p, which modulates Npl3p function inmRNA processing and export; has similarity toAir2p 0.008820.15455&radic&radic S000004106MSL5YLR116WverifiedComponent of the commitment complex, which defines the firststep in the splicing pathway; essential proteinthat interacts with Mud2p and Prp40p, forming abridge between the intron ends; also involvedin nuclear retention of pre-mRNA 0.008480.14978&radic&radic&radic&radic S000003427SKI6YGR195Wverified3'-to-5' phosphorolytic exoribonuclease that is a subunit ofthe exosome; required for 3' processing of the5.8S rRNA; involved in 3' to 5' mRNAdegradation and translation inhibition ofnon-poly(A) mRNAs 0.008340.14815&radic&radic&radic&radic&radic S000005898GPB1YOR371CverifiedProposed beta subunit of the heterotrimeric G protein;interacts with the receptor Grp1p, affectssignaling by altering the level ofphosphorylation of PKS substrates; regulatespseudohyphal growth through cAMP levels;homolog of Gpb2p 0.008330.14786&radic&radic S000002334AIR2YDL175CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p; may regulatemethylation of Npl3p, which modulates Npl3pfunction in mRNA processing and export; hassimilarity to Air1p 0.008270.14711&radic&radic S000004961PUB1YNL016WverifiedPoly(A)+ RNA-binding protein, abundant mRNP-component proteinthat binds mRNA and is required for stabilityof a number of mRNAs; not reported to associatewith polyribosomes 0.008220.14623&radic&radic S000002495SLU7YDR088CverifiedRNA splicing factor, required for ATP-independent portion of2nd catalytic step of spliceosomal RNAsplicing; interacts with Prp18p; contains zincknuckle domain 0.008170.14535&radic&radic&radic&radic S000001411MLP2YIL149CverifiedMyosin-like protein associated with the nuclear envelope,connects the nuclear pore complex with thenuclear interior; involved in the Tel1p pathwaythat controls telomere length 0.008040.14363&radic S000003959PRP19YLL036CverifiedSplicing factor associated with the spliceosome; contains aU-box, a motif found in a class of ubiquitinligases 0.007730.13869&radic&radic&radic S000005243TRF5YNL299WverifiedPoly (A) polymerase involved in nuclear RNA quality controlbased on: homology with Trf4p, geneticinteractions with TRF4 mutants, physicalinteraction with Mtr4p (TRAMP subunit), and bydirect assay; disputed role as a sigma DNApolymerase 0.007350.13168&radic S000005199GIS2YNL255CverifiedProtein with seven cysteine-rich CCHC zinc-finger motifs,similar to human CNBP, proposed to be involvedin the RAS/cAMP signaling pathway 0.00730.13056&radic&radic S000001622CTK1YKL139WverifiedCatalytic (alpha) subunit of C-terminal domain kinase I(CTDK-I), which phosphorylates the C-terminalrepeated domain of the RNA polymerase II largesubunit (Rpo21p) to affect both transcriptionand pre-mRNA 3' end processing 0.00720.1293&radic&radic&radic S000003280UFD1YGR048WverifiedProtein that interacts with Cdc48p and Npl4p, involved inrecognition of polyubiquitinated proteins andtheir presentation to the 26S proteasome fordegradation; involved in transporting proteinsfrom the ER to the cytosol 0.007170.12906&radic S000005566GLO4YOR040WverifiedMitochondrial glyoxalase II, catalyzes the hydrolysis ofS-D-lactoylglutathione into glutathione andD-lactate 0.006920.1244&radic&radic&radic S000001501SWD2YKL018WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lys 4 and is involved intelomeric silencing; subunit of CPF (cleavageand polyadenylation factor), a complex involvedin RNAP II transcription termination 0.006450.11711&radic&radic&radic S000001450STS1YIR011CverifiedProtein that interacts with the karyopherin Srp1p; may have arole with Srp1p in ubiquitin-mediated proteindegradation 0.006430.11645&radic&radic S000002680GLO2YDR272WverifiedCytoplasmic glyoxalase II, catalyzes the hydrolysis ofS-D-lactoylglutathione into glutathione andD-lactate 0.006390.11583&radic&radic&radic&radic S000005401NOP12YOL041CverifiedNucleolar protein, required for pre-25S rRNA processing;contains an RNA recognition motif (RRM) and hassimilarity to Nop13p, Nsr1p, and putativeorthologs in Drosophila and S. pombe 0.006120.11148&radic&radic&radic&radic S000004685NAM7YMR080CverifiedATP-dependent RNA helicase of the SFI superfamily, required fornonsense mediated mRNA decay and for efficienttranslation termination at nonsense codons;involved in telomere maintenance 0.006110.1112 S000005524BDS1YOL164WverifiedBacterially-derived sulfatase required for use of alkyl- andaryl-sulfates as sulfur sources 0.006110.11083 S000005433THP1YOL072WverifiedNuclear pore-associated protein, forms a complex with Sac3pthat is involved in transcription and in mRNAexport from the nucleus; contains a PAM domainimplicated in protein-protein binding 0.005960.10837&radic&radic&radic S000005929CHL1YPL008WverifiedConserved nuclear protein required to establishsister-chromatid pairing during S-phase,probable DNA helicase with similarity to humanBACH1, which associates with tumor suppressorBRCA1; associates with acetyltransferase Ctf7p 0.005910.1071&radic&radic&radic&radic S000005133SRP1YNL189WverifiedKaryopherin alpha homolog, forms a dimer with karyopherin betaKap95p to mediate import of nuclear proteins,binds the nuclear localization signal of thesubstrate during import; may also play a rolein regulation of protein degradation 0.005820.10563&radic&radic&radic&radic&radic S000002432RPS11AYDR025WverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps11Bp and has similarity to E.coli S17 and rat S11 ribosomal proteins 0.005820.10495&radic S000006161HSP82YPL240CverifiedCytoplasmic chaperone (Hsp90 family) required for pheromonesignaling and negative regulation of Hsf1p;docks with the mitochondrial import receptorTom70p for preprotein delivery; interacts withco-chaperones Cns1p, Cpr6p, Cpr7p, and Sti1p 0.005770.10438&radic&radic&radic&radic S000006132NIP7YPL211WverifiedNucleolar protein required for 60S ribosome subunit biogenesis,constituent of 66S pre-ribosomal particles;physically interacts with Nop8p and the exosomesubunit Rrp43p 0.00570.10271&radic&radic&radic&radic S000003969RNP1YLL046CverifiedRibonucleoprotein that contains two RNA recognition motifs(RRM) 0.005640.10144&radic&radic&radic S000003506TAF1YGR274CverifiedTFIID subunit (145 kDa), involved in RNA polymerase IItranscription initiation, has histoneacetyltransferase activity, involved inpromoter binding and G1/S progression 0.005590.1005&radic&radic&radic&radic&radic&radic S000004668AEP1YMR064WverifiedProtein required for expression of the mitochondrial OLI1 geneencoding subunit 9 of F1-F0 ATP synthase 0.005580.1005 S000002506BMH2YDR099Wverified14-3-3 protein, minor isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others 0.005550.09956&radic&radic&radic&radic S000006141RPL1AYPL220WverifiedN-terminally acetylated protein component of the large (60S)ribosomal subunit, nearly identical to Rpl1Bpand has similarity to E. coli L1 and rat L10aribosomal proteins; rpl1a rpl1b double nullmutation is lethal 0.005550.09956&radic&radic&radic&radic S000004315CWC24YLR323CverifiedEssential protein, component of a complex containing Cef1p; hassimilarity to S. pombe Cwf24p 0.005520.09911&radic&radic&radic S000000979BMH1YER177Wverified14-3-3 protein, major isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others 0.00550.09866 S000005617TMA46YOR091WverifiedProtein of unknown function that associates with ribosomes;interacts with GTPase Rbg1p 0.00550.09866&radic S000001022ECM29YHL030WverifiedMajor component of the proteasome; tethers the proteasome coreparticle to the regulatory particle, andenhances the stability of the proteasome 0.00550.09866&radic&radic&radic&radic&radic&radic S000005823TIM18YOR297CverifiedComponent of the mitochondrial Tim54p-Tim22p complex involvedin insertion of polytopic proteins into theinner membrane; may function to stabilize thecomplex 0.005490.09838&radic S000002558CTH1YDR151CverifiedMember of the CCCH zinc finger family; has similarity tomammalian Tis11 protein, which activatestranscription and also has a role in mRNAdegradation; may function with Tis11p in ironhomeostasis 0.005290.0944&radic S000004140STM1YLR150WverifiedProtein that binds G4 quadruplex and purine motif triplexnucleic acid; acts with Cdc13p to maintaintelomere structure; interacts with ribosomesand subtelomeric Y' DNA; multicopy suppressorof tom1 and pop2 mutations 0.005230.09308&radic&radic&radic S000004614CLU1YMR012WverifiedeIF3 component of unknown function; deletion causes defects inmitochondrial organization but not in growth ortranslation initiation, can rescue cytokinesisand mitochondrial organization defects of theDictyostelium cluA- mutant 0.005190.09255&radic&radic S000000973RAD3YER171Wverified5' to 3' DNA helicase, involved in nucleotide excision repairand transcription; subunit of RNA polymerase IItranscription initiation factor TFIIH; subunitof Nucleotide Excision Repair Factor 3 (NEF3);homolog of human XPD protein 0.005140.09138&radic S000000638TAF2YCR042CverifiedTFIID subunit (150 kDa), involved in RNA polymerase IItranscription initiation 0.005110.09082&radic S000005733RET1YOR207CverifiedSecond-largest subunit of RNA polymerase III, which isresponsible for the transcription of tRNA and5S RNA genes, and other low molecular weightRNAs 0.005040.08976&radic&radic&radic&radic S000005076KRE33YNL132WverifiedEssential protein of unknown function; heterozygous mutantshows haploinsufficiency in K1 killer toxinresistance 0.005020.08942&radic S000004393DUS3YLR401CuncharacterizedDihydrouridine synthase, member of a widespread family ofconserved proteins including Smm1p, Dus1p, andDus4p; contains a consensus oleate responseelement (ORE) in its promoter region 0.004830.0855&radic&radic S000004911LCB1YMR296CverifiedComponent of serine palmitoyltransferase, responsible alongwith Lcb2p for the first committed step insphingolipid synthesis, which is thecondensation of serine with palmitoyl-CoA toform 3-ketosphinganine 0.004770.08405&radic&radic&radic S000004470SPT5YML010WverifiedProtein that forms a complex with Spt4p and mediates bothactivation and inhibition of transcriptionelongation; Spt4p-Spt5p complex also plays arole in pre-mRNA processing 0.004760.08405&radic&radic S000001025RPL8AYHL033CverifiedRibosomal protein L4 of the large (60S) ribosomal subunit,nearly identical to Rpl8Bp and has similarityto rat L7a ribosomal protein; mutation resultsin decreased amounts of free 60S subunits 0.004670.08252&radic S000004440RPL6BYLR448WverifiedProtein component of the large (60S) ribosomal subunit, hassimilarity to Rpl6Bp and to rat L6 ribosomalprotein; binds to 5.8S rRNA 0.00460.08151 S000004650NUP116YMR047CverifiedSubunit of the nuclear pore complex (NPC) that is localized toboth sides of the pore; contains a repetitiveGLFG motif that interacts with mRNA exportfactor Mex67p and with karyopherin Kap95p;homologous to Nup100p 0.004590.08134&radic&radic S000005337ESF2YNR054CverifiedEssential nucleolar protein involved in pre-18S rRNAprocessing; component of the small subunit(SSU) processome; has sequence similarity tomABT1, a mouse transcription activator 0.004540.08024&radic&radic S000004126TIS11YLR136CverifiedmRNA-binding protein expressed during iron starvation; binds toa sequence element in the 3'-untranslatedregions of specific mRNAs to mediate theirdegradation; involved in iron homeostasis 0.00450.07942&radic&radic&radic S000004332RPP0YLR340WverifiedConserved ribosomal protein P0 similar to rat P0, human P0, andE. coli L10e; shown to be phosphorylated onserine 302 0.004470.07894&radic&radic S000004134ACF2YLR144CverifiedIntracellular beta-1,3-endoglucanase, expression is inducedduring sporulation; may have a role in corticalactin cytoskeleton assembly 0.004320.07597&radic&radic&radic&radic&radic S000003163GCN1YGL195WverifiedPositive regulator of the Gcn2p kinase activity, forms acomplex with Gcn20p; proposed to stimulateGcn2p activation by an uncharged tRNA 0.00430.0757&radic S000001292SSM4YIL030CverifiedUbiquitin-protein ligase of the ER/nuclear envelope, requiredfor degradation of Alpha2p and other proteinscontaining a Deg1 degradation signal; ssm4mutation suppresses mRNA instability caused byan rna14 mutation 0.004260.07492 S000003484GCN5YGR252WverifiedHistone acetyltransferase, acetylates N-terminal lysines onhistones H2B and H3; catalytic subunit of theADA and SAGA histone acetyltransferasecomplexes; founding member of the Gcn5p-relatedN-acetyltransferase superfamily 0.004170.07295&radic&radic S000002910SAM2YDR502CverifiedS-adenosylmethionine synthetase, catalyzes transfer of theadenosyl group of ATP to the sulfur atom ofmethionine; one of two differentially regulatedisozymes (Sam1p and Sam2p) 0.004150.07262 S000006074RAD53YPL153CverifiedProtein kinase, required for cell-cycle arrest in response toDNA damage; activated by transautophosphorylation when interacting withhyperphosphorylated Rad9p; also interacts withARS1 and plays a role in initiation of DNAreplication 0.004160.07262&radic&radic&radic&radic S000000064SWD1YAR003WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres; WD40beta propeller superfamily member withsimilarity to mammalian Rbbp7 0.004060.07023&radic S000003570HCA4YJL033WverifiedPutative nucleolar DEAD box RNA helicase; high-copy numbersuppression of a U14 snoRNA processing mutantsuggests an involvement in 18S rRNA synthesis 0.004040.07023&radic S000002600NUP42YDR192CverifiedSubunit of the nuclear pore complex (NPC) that localizesexclusively to the cytoplasmic side; involvedin RNA export, most likely at a terminal step;interacts with Gle1p 0.004010.06974&radic S000001444IST3YIR005WverifiedComponent of the U2 snRNP, required for the first catalyticstep of splicing and for spliceosomal assembly;interacts with Rds3p and is required forMer1p-activated splicing 0.004020.06974&radic&radic S000001123LRP1YHR081WverifiedSubstrate-specific nuclear cofactor for exosome activity in theprocessing of stable RNAs; required fortelomere length maintenance; homolog ofmammalian nuclear matrix protein C1D involvedin regulation of DNA repair and recombination 0.003970.06884&radic S000000939YER137CUncharacterizedHypothetical protein 0.003920.06757 S000003968RPL8BYLL045CverifiedRibosomal protein L4 of the large (60S) ribosomal subunit,nearly identical to Rpl8Ap and has similarityto rat L7a ribosomal protein; mutation resultsin decreased amounts of free 60S subunits 0.00390.06735&radic&radic S000005366TOP1YOL006CverifiedTopoisomerase I, nuclear enzyme that relieves torsional strainin DNA by cleaving and re-sealing thephosphodiester backbone; relaxes bothpositively and negatively supercoiled DNA;functions in replication, transcription, andrecombination 0.003870.06651&radic&radic&radic&radic S000001331RPS24BYIL069CverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps24Ap and has similarity to ratS24 ribosomal protein 0.003850.06597 S000003202SEC15YGL233WverifiedEssential 113kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which mediates polarized targeting ofvesicles to active sites of exocytosis; Sec15passociates with Sec4p and vesicles 0.003830.06568&radic&radic&radic S000004424IMD3YLR432WverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 0.003820.06528 S000005054NOP15YNL110CverifiedConstituent of 66S pre-ribosomal particles, involved in 60Sribosomal subunit biogenesis; localizes to bothnucleolus and cytoplasm 0.003770.06405&radic&radic&radic S000002209LHP1YDL051WverifiedRNA binding protein required for maturation of tRNA and snRNAprecursors; acts as a molecular chaperone forRNAs transcribed by polymerase III; homologousto human La (SS-B) autoantigen 0.003760.06405&radic&radic S000004699UTP15YMR093WverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.003710.06303&radic&radic&radic S000000168RPS8AYBL072CverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps8Bp and has similarity to ratS8 ribosomal protein 0.003690.06268&radic&radic&radic&radic S000002620TCP1YDR212WverifiedAlpha subunit of chaperonin-containing T-complex, whichmediates protein folding in the cytosol;involved in maintenance of actin cytoskeleton;homolog to Drosophila melanogaster and mousetailless complex polypeptide 0.003680.06239&radic&radic&radic&radic S000005846HSH49YOR319WverifiedU2-snRNP associated splicing factor with similarity to themammalian splicing factor SAP49; proposed tofunction as a U2-snRNP assembly factor alongwith Hsh155p and binding partner Cus1p;contains two RNA recognition motifs (RRM) 0.003670.06225&radic&radic&radic&radic&radic&radic&radic S000001323SNP1YIL061CverifiedComponent of U1 snRNP required for mRNA splicing viaspliceosome; may interact with poly(A)polymerase to regulate polyadenylation; homologof human U1 70K protein 0.003660.06215&radic&radic&radic S000005589RPL3YOR063WverifiedProtein component of the large (60S) ribosomal subunit, hassimilarity to E. coli L3 and rat L3 ribosomalproteins; involved in the replication andmaintenance of killer double stranded RNA virus 0.003590.06082&radic&radic&radic&radic S000000172ILS1YBL076CverifiedCytoplasmic isoleucine-tRNA synthetase, target of theG1-specific inhibitor reveromycin A 0.00360.06082&radic&radic S000000929LCP5YER127WverifiedEssential protein involved in maturation of 18S rRNA; depletionleads to inhibited pre-rRNA processing andreduced polysome levels; localizes primarily tothe nucleolus 0.003610.06082&radic S000001259IMD2YHR216WverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, expression is induced bymycophenolic acid resulting in resistance tothe drug, expression is repressed by nutrientlimitation 0.003570.05968 S000003783LSM8YJR022WverifiedLsm (Like Sm) protein; forms heteroheptameric complex (withLsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p)that is part of spliceosomal U6 snRNP and isalso implicated in processing of pre-tRNA,pre-snoRNA, and pre-rRNA 0.003550.05968&radic&radic S000000748GEA2YEL022WverifiedGuanine nucleotide exchange factor for ADP ribosylation factors(ARFs), involved in vesicular transport betweenthe Golgi and ER, Golgi organization, and actincytoskeleton organization; similar to but notfunctionally redundant with Gea1p 0.003570.05968 S000003391NSR1YGR159CverifiedNucleolar protein that binds nuclear localization sequences,required for pre-rRNA processing and ribosomebiogenesis 0.003520.05925&radic&radic&radic&radic&radic S000001057MIP6YHR015WverifiedPutative RNA-binding protein, interacts with Mex67p, which is acomponent of the nuclear pore involved innuclear mRNA export 0.003490.05888&radic&radic&radic&radic S000006099CBC2YPL178WverifiedSmall subunit of the heterodimeric cap binding complex thatalso contains Sto1p, component of thespliceosomal commitment complex; interacts withNpl3p, possibly to package mRNA for export fromthe nucleus; contains an RNA-binding motif 0.00350.05888&radic&radic&radic&radic&radic&radic S000001026SBP1YHL034CverifiedNucleolar single-strand nucleic acid binding protein;associates with small nuclear RNAs 0.003460.05833&radic&radic&radic&radic&radic&radic S000001448MSL1YIR009WverifiedU2B component of U2 snRNP, involved in splicing, binds the U2snRNA stem-loop IV in vitro; does not containthe conserved C-terminal RNA binding domainfound in other family members 0.003450.05808&radic&radic S000004636ARP9YMR033WverifiedActin-related protein involved in transcriptional regulation;subunit of the chromatin remodeling Snf/Swicomplex 0.003430.05753 S000001928YFR032CUncharacterizedPutative protein of unknown function; transcribed during sporulation; YFR032C is not an essential gene 0.003420.05753&radic S000006316MRD1YPR112CverifiedEssential conserved protein that associates with 35S precursorrRNA and is required for its initial processingat the A(0)-A(2) cleavage sites, shows partialnucleolar localization, contains five consensusRNA-binding domains 0.003420.05753&radic&radic S000001071YHI9YHR029CverifiedProtein of unknown function that is a member of the PhzFsuperfamily, although unlike its bacterialhomolog, is most likely not involved inphenazine production; possibly involved in amembrane regulation metabolic pathway 0.00340.05728&radic&radic&radic S000002982PUF4YGL014WverifiedMember of the PUF protein family, which is defined by thepresence of Pumilio homology domains thatconfer RNA binding activity; preferentiallybinds mRNAs encoding nucleolar ribosomalRNA-processing factors 0.003380.05705&radic&radic&radic S000001440SGN1YIR001CverifiedCytoplasmic RNA-binding protein, contains an RNA recognitionmotif (RRM); may have a role in mRNAtranslation, as suggested by geneticinteractions with genes encoding proteinsinvolved in translational initiation 0.003380.05705&radic&radic S000001551NUP100YKL068WverifiedSubunit of the nuclear pore complex (NPC) that is localized toboth sides of the pore; contains a repetitiveGLFG motif that interacts with mRNA exportfactor Mex67p and with karyopherin Kap95p;homologous to Nup116p 0.003350.0565&radic&radic S000000870MOT2YER068WverifiedComponent of the CCR4-NOT complex, which has multiple roles intranscription regulation, mRNA degradation, andpost-transcriptional modifications; with Ubc4p,ubiquitylates subunits of the nascentpolypeptide-associated complex (NAC) 0.003340.0565&radic&radic&radic S000006002RPS9AYPL081WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps9Bp and has similarity to E.coli S4 and rat S9 ribosomal proteins 0.003320.05627&radic&radic&radic S000000029GIP4YAL031CverifiedCytoplasmic Glc7-interacting protein whose overexpressionrelocalizes Glc7p from the nucleus and preventschromosome segregation; potential Cdc28psubstrate 0.00330.05595&radic&radic&radic&radic S000004034PDC1YLR044CverifiedMajor of three pyruvate decarboxylase isozymes, key enzyme inalcoholic fermentation, decarboxylates pyruvateto acetaldehyde; subject to glucose-, ethanol-,and autoregulation; involved in amino acidcatabolism 0.003290.05549&radic&radic&radic&radic&radic S000004794RGM1YMR182CverifiedPutative transcriptional repressor with proline-rich zincfingers; overproduction impairs cell growth 0.003270.05519&radic&radic&radic&radic&radic&radic S000004294MET17YLR303WverifiedO-acetyl homoserine-O-acetyl serine sulfhydrylase, required forsulfur amino acid synthesis 0.003270.05519&radic S000002667YAP6YDR259CverifiedPutative basic leucine zipper (bZIP) transcription factor;overexpression increases sodium and lithiumtolerance 0.003270.05519&radic&radic&radic&radic S000003838MIR1YJR077CverifiedMitochondrial phosphate carrier, imports inorganic phosphateinto mitochondria; functionally redundant withPic2p but more abundant than Pic2 under normalconditions 0.003260.05515 S000003419HGH1YGR187CverifiedProtein of unknown function with similarity to human HMG1 andHMG2; localizes to the cytoplasm 0.003260.05515&radic&radic S000002837TIF35YDR429CverifiedSubunit of the core complex of translation initiation factor3(eIF3), which is essential for translation 0.003250.0551&radic&radic&radic S000004873TIF11YMR260CverifiedTranslation initiation factor eIF1A, essential protein thatforms a complex with Sui1p (eIF1) and the 40Sribosomal subunit and scans for the startcodon; C-terminus associates with Fun12p(eIF5B); N terminus interacts with eIF2 andeIF3 0.003240.05484&radic&radic&radic&radic S000004170SAM1YLR180WverifiedS-adenosylmethionine synthetase, catalyzes transfer of theadenosyl group of ATP to the sulfur atom ofmethionine; one of two differentially regulatedisozymes (Sam1p and Sam2p) 0.003220.05462&radic&radic S000002372NOP6YDL213CuncharacterizedProtein with similarity to hydrophilins, which are involved inthe adaptive response to hyperosmoticconditions; computational analysis oflarge-scale protein-protein interaction datasuggests a possible role in rRNA processing 0.003180.05395&radic&radic S000005888PRT1YOR361CverifiedSubunit of the core complex of translation initiation factor3(eIF3), essential for translation; part of asubcomplex (Prt1p-Rpg1p-Nip1p) that stimulatesbinding of mRNA and tRNA(i)Met to ribosomes 0.00320.05395&radic&radic&radic&radic S000001156BZZ1YHR114WverifiedSH3 domain protein implicated in the regulation of actinpolymerization, able to recruit actinpolymerization machinery through its SH3domains, colocalizes with cortical actinpatches and Las17p, interacts with type Imyosins 0.003130.05306&radic&radic&radic&radic S000001697YRA2YKL214CverifiedMember of the REF (RNA and export factor binding proteins)family; when overexpressed, can substitute forthe function of Yra1p in export of poly(A)+mRNA from the nucleus 0.003140.05306&radic&radic&radic S000003098CEG1YGL130WverifiedAlpha (guanylyltransferase) subunit of the mRNA capping enzyme,a heterodimer (the other subunit is CET1, anRNA 5'-triphophatase) involved in adding the 5'cap to mRNA; the mammalian enzyme is a singlebifunctional polypeptide 0.003160.05306&radic S000001587GFA1YKL104CverifiedGlutamine-fructose-6-phosphate amidotransferase, catalyzes theformation of glucosamine-6-P and glutamate fromfructose-6-P and glutamine in the first step ofchitin biosynthesis 0.003110.05278 S000006367TIF3YPR163CverifiedTranslation initiation factor eIF-4B, has RNA annealingactivity; contains an RNA recognition motif andbinds to single-stranded RNA 0.003110.05278&radic&radic&radic S000001557MUD2YKL074CverifiedProtein involved in early pre-mRNA splicing; component of thepre-mRNA-U1 snRNP complex, the commitmentcomplex; interacts with Msl5p/BBP splicingfactor and Sub2p; similar to metazoan splicingfactor U2AF65 0.00310.05269&radic&radic&radic&radic&radic&radic&radic S000000884UTP7YER082CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.003070.05211&radic&radic&radic&radic S000005619YOR093CUncharacterizedHypothetical protein 0.003090.05211&radic&radic&radic S000004883RRN9YMR270CverifiedProtein involved in promoting high level transcription of rDNA,subunit of UAF (upstream activation factor) forRNA polymerase I 0.003060.05211&radic&radic&radic&radic&radic S000001725YKR017CUncharacterizedPutative protein of unknown function; contains a RING finger motif 0.003080.05211&radic S000004334FKS1YLR342WverifiedCatalytic subunit of 1,3-beta-D-glucan synthase, functionallyredundant with alternate catalytic subunitGsc2p; binds to regulatory subunit Rho1p;involved in cell wall synthesis andmaintenance; localizes to sites of cell wallremodeling 0.003040.05175 S000005975LEE1YPL054WverifiedZinc-finger protein of unknown function 0.003020.05162&radic&radic&radic S000000532FUS1YCL027WverifiedMembrane protein localized to the shmoo tip, required for cellfusion; expression regulated by matingpheromone; proposed to coordinate signaling,fusion, and polarization events required forfusion; potential Cdc28p substrate 0.003030.05162&radic&radic&radic&radic S000000747URA3YEL021WverifiedOrotidine-5'-phosphate (OMP) decarboxylase, catalyzes the sixthenzymatic step in the de novo biosynthesis ofpyrimidines, converting OMP into uridinemonophosphate (UMP); converts 5-FOA into5-fluorouracil, a toxic compound 0.003030.05162 S000005334BRE5YNR051CverifiedUbiquitin protease cofactor, forms deubiquitination complexwith Ubp3p that coregulates anterograde andretrograde transport between the endoplasmicreticulum and Golgi compartments; null issensitive to brefeldin A 0.003010.05122&radic S000005257YNL313CUncharacterizedProtein required for cell viability 0.002990.051&radic S000005504NOP8YOL144WverifiedNucleolar protein required for 60S ribosomal subunit biogenesis 0.002980.0508&radic S000002412MAF1YDR005CverifiedNegative regulator of RNA polymerase III; component of severalsignaling pathways that repress polymerase IIItranscription in response to changes incellular environment; targets the initiationfactor TFIIIB 0.002980.0508&radic&radic S000002596CCT6YDR188WverifiedSubunit of the cytosolic chaperonin Cct ring complex, relatedto Tcp1p, essential protein that is requiredfor the assembly of actin and tubulins in vivo;contains an ATP-binding motif 0.002970.0508&radic&radic&radic&radic S000006105MRN1YPL184CuncharacterizedPutative RNA binding protein 0.002960.0506&radic&radic S000005119NOP13YNL175CverifiedProtein of unknown function, localizes to the nucleolus andnucleoplasm; contains an RNA recognition motif(RRM) and has similarity to Nop12p, which isrequired for processing of pre-18S rRNA 0.002960.0505&radic&radic&radic&radic&radic&radic S000002719TFB1YDR311WverifiedSubunit of TFIIH and nucleotide excision repair factor 3complexes, required for nucleotide excisionrepair, target for transcriptional activators 0.002940.05002&radic&radic&radic&radic S000006348NOC4YPR144CverifiedNucleolar protein, forms a complex with Nop14p that mediatesmaturation and nuclear export of 40S ribosomalsubunits 0.00290.04975&radic&radic&radic&radic&radic S000001062YHR020WUncharacterizedPutative protein of unknown function, has similarity to proline-tRNA ligase; YHR020W is an essential gene 0.00290.04968&radic&radic&radic S000004072SRL2YLR082CverifiedProtein of unknown function; overexpression suppresses thelethality caused by a rad53 null mutation 0.002890.04957&radic&radic&radic&radic S000005101IGO1YNL157WuncharacterizedHypothetical protein 0.002890.04957&radic&radic S000001404CCT2YIL142WverifiedSubunit beta of the cytosolic chaperonin Cct ring complex,related to Tcp1p, required for the assembly ofactin and tubulins in vivo 0.002880.04945 S000001876LPD1YFL018CverifiedDihydrolipoamide dehydrogenase, the lipoamide dehydrogenasecomponent (E3) of the pyruvate dehydrogenaseand 2-oxoglutarate dehydrogenase multi-enzymecomplexes 0.002870.04922&radic&radic&radic&radic S000002368CWC2YDL209CverifiedProtein involved in pre-mRNA splicing, component of a complexcontaining Cef1p; interacts with Prp19p;contains an RNA recognition motif; hassimilarity to S. pombe Cwf2p 0.002870.04922&radic&radic S000006111NAB3YPL190CverifiedSingle stranded DNA binding protein; acidic ribonucleoprotein;required for termination of non-poly(A)transcripts and efficient splicing; interactswith Nrd1p 0.002840.04864&radic&radic&radic S000001128NAM8YHR086WverifiedRNA binding protein, component of the U1 snRNP protein; mutantsare defective in meiotic recombination and information of viable spores, involved in theformation of DSBs through meiosis-specificsplicing of MER2 pre-mRNA 0.002840.04864&radic&radic&radic&radic&radic S000004762NUP53YMR153WverifiedSubunit of the nuclear pore complex (NPC), interacts withkaryopherin Kap121p or with Nup170p viaoverlapping regions of Nup53p, involved inactivation of the spindle checkpoint mediatedby the Mad1p-Mad2p complex 0.002830.04864&radic&radic&radic&radic S000006278TKL1YPR074CverifiedTransketolase, similar to Tkl2p; catalyzes conversion ofxylulose-5-phosphate and ribose-5-phosphate tosedoheptulose-7-phosphate andglyceraldehyde-3-phosphate in the pentosephosphate pathway; needed for synthesis ofaromatic amino acids 0.002860.04864&radic S000006284TEF1YPR080WverifiedTranslational elongation factor EF-1 alpha; also encoded byTEF2; functions in the binding reaction ofaminoacyl-tRNA (AA-tRNA) to ribosomes 0.002860.04864 S000004490TSA1YML028WverifiedUbiquitous housekeeping thioredoxin peroxidase, reducesreactive oxygen, nitrogen and sulfur speciesusing thioredoxin as hydrogen donor; mediatesredox regulation of the nuclear localization ofYap1p; deletion results in mutator phenotype 0.002830.04857&radic S000001016RIM4YHL024WverifiedPutative RNA-binding protein required for the expression ofearly and middle sporulation genes 0.002810.04843&radic S000003410PBP1YGR178CverifiedProtein interacting with poly(A)-binding protein Pab1p; likelyinvolved in controlling the extent of mRNApolyadenylation; forms a complex with Mkt1pthat may regulate HO translation; interactswith Lsm12p in a copurification assay &radic0.002810.04821&radic&radic&radic&radic&radic&radic S000002358YDL199CUncharacterizedPutative protein of unknown function with sequence similarity to members of the sugar permease family 0.002790.04779 S000000741EDC3YEL015WverifiedNon-essential conserved protein of unknown function, plays arole in mRNA decapping by specificallyaffecting the function of the decapping enzymeDcp1p; localizes to cytoplasmic mRNA processingbodies 0.002790.04779&radic&radic&radic&radic S000001356LYS12YIL094CverifiedHomo-isocitrate dehydrogenase, an NAD-linked mitochondrialenzyme required for the fourth step in thebiosynthesis of lysine, in whichhomo-isocitrate is oxidatively decarboxylatedto alpha-ketoadipate 0.002780.04779 S000000893MET6YER091CverifiedCobalamin-independent methionine synthase, involved in aminoacid biosynthesis; requires a minimum of twoglutamates on the methyltetrahydrofolatesubstrate, similar to bacterial metE homologs 0.002780.04779 S000002383WHI4YDL224CverifiedPutative RNA binding protein and partially redundant Whi3phomolog that regulates the cell sizerequirement for passage through Start andcommitment to cell division 0.002760.04763&radic&radic S000005036YNL092WUncharacterizedPutative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene 0.002760.04763&radic S000004949HRB1YNL004WverifiedPoly(A+) RNA-binding protein, involved in the export of mRNAsfrom the nucleus to the cytoplasm; similar toGbp2p and Npl3p 0.002760.04763&radic&radic S000003825CCT5YJR064WverifiedSubunit of the cytosolic chaperonin Cct ring complex, relatedto Tcp1p, required for the assembly of actinand tubulins in vivo 0.002750.04734 S000005964NOP4YPL043WverifiedNucleolar protein, essential for processing and maturation of27S pre-rRNA and large ribosomal subunitbiogenesis; constituent of 66S pre-ribosomalparticles; contains four RNA recognition motifs(RRMs) 0.002750.04734&radic&radic&radic&radic S000002319DHH1YDL160CverifiedCytoplasmic DExD/H-box helicase, stimulates mRNA decapping,coordinates distinct steps in mRNA function anddecay, interacts with both the decapping anddeadenylase complexes, may have a role in mRNAexport and translation 0.002710.04697&radic S000004421CRN1YLR429WverifiedCoronin, cortical actin cytoskeletal component that associateswith the Arp2p/Arp3p complex to regulate itsactivity 0.002730.04697 S000000106YBL010CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles 0.002690.04657&radic&radic&radic S000002591PLP1YDR183WverifiedProtein with a possible role in folding of beta-tubulin; hassimilarity to phosducins, which are GTPaseinhibitors 0.002680.04617&radic&radic&radic S000001195SPO12YHR152WverifiedNucleolar protein of unknown function, positive regulator ofexit from mitosis; involved in regulating therelease of Cdc14p from the nucleolus in earlyanaphase; proposed to play similar role inmeiosis 0.002660.04617&radic&radic&radic&radic S000002913PSP1YDR505CverifiedAsn and gln rich protein of unknown function; high-copysuppressor of POL1 (DNA polymerase alpha) andpartial suppressor of CDC2 (polymerase delta)and CDC6 (pre-RC loading factor) mutations;overexpression results in growth inhibition 0.002670.04617&radic S000000409KTR3YBR205WverifiedPutative alpha-1,2-mannosyltransferase involved in O- andN-linked protein glycosylation; member of theKRE2/MNT1 mannosyltransferase family 0.002660.04617&radic&radic&radic&radic S000004520IMD4YML056CverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 0.002650.04617 S000000030PRP45YAL032CverifiedProtein required for pre-mRNA splicing; associates with thespliceosome and interacts with splicing factorsPrp22p and Prp46p; orthologous to humantranscriptional coactivator SKIP and canactivate transcription of a reporter gene 0.002650.04615&radic&radic&radic&radic S000002292PPH21YDL134CverifiedCatalytic subunit of protein phosphatase 2A, functionallyredundant with Pph22p; methylated at Cterminus; forms alternate complexes withseveral regulatory subunits; involved in signaltransduction and regulation of mitosis 0.002640.04604&radic S000000517GBP2YCL011CverifiedPoly(A+) RNA-binding protein, involved in the export of mRNAsfrom the nucleus to the cytoplasm; similar toHrb1p and Npl3p; also binds single-strandedtelomeric repeat sequence in vitro 0.002640.04604&radic&radic&radic&radic&radic&radic S000005068NAF1YNL124WverifiedProtein required for the assembly of box H/ACA snoRNPs and forpre-rRNA processing, forms a complex with Shq1pand interacts with H/ACA snoRNP componentsNhp2p and Cbf5p; has similarity to Gar1p andother RNA-binding proteins 0.002640.04604&radic S000005141WHI3YNL197CverifiedRNA binding protein that sequesters CLN3 mRNA in cytoplasmicfoci; cytoplasmic retention factor for Cdc28pand associated cyclins; regulates cell fate anddose-dependently regulates the critical cellsize required for passage through Start 0.002640.04595&radic&radic&radic S000001734GCN3YKR026CverifiedAlpha subunit of the translation initiation factor eIF2B, theguanine-nucleotide exchange factor for eIF2;activity subsequently regulated byphosphorylated eIF2; first identified as apositive regulator of GCN4 expression 0.002640.04595&radic&radic&radic S000003608PSF2YJL072CverifiedSubunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), whichis localized to DNA replication origins andimplicated in assembly of the DNA replicationmachinery 0.002640.04595 S000002326NRP1YDL167CverifiedProtein of unknown function, rich in asparagine residues 0.002630.04584&radic S000000044YAL046CUncharacterizedHypothetical protein 0.002620.04584&radic S000000370TYR1YBR166CverifiedPrephenate dehydrogenase involved in tyrosine biosynthesis,expression is dependent on phenylalanine levels 0.002630.04584 S000002856ADA2YDR448WverifiedTranscription coactivator, component of the ADA and SAGAtranscriptional adaptor/HAT (histoneacetyltransferase) complexes 0.002610.04544&radic&radic S000005230CUS2YNL286WverifiedProtein that binds to U2 snRNA and Prp11p, may be involved inU2 snRNA folding; contains two RNA recognitionmotifs (RRMs) 0.00260.04544&radic&radic S000001447PRI1YIR008CverifiedSubunit of DNA primase, which is required for DNA synthesis anddouble-strand break repair 0.002610.04544 S000003482YGR250CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.002620.04544&radic S000000197ECM21YBL101CverifiedNon-essential protein of unknown function; promoter containsseveral Gcn4p binding elements 0.00260.04544 S000005013RPL16BYNL069CverifiedN-terminally acetylated protein component of the large (60S)ribosomal subunit, binds to 5.8 S rRNA; hassimilarity to Rpl16Ap, E. coli L13 and rat L13aribosomal proteins; transcriptionally regulatedby Rap1p 0.002580.04509 S000000993RPL14BYHL001WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl14Ap and has similarity to ratL14 ribosomal protein 0.002580.04509 S000001489RPL14AYKL006WverifiedN-terminally acetylated protein component of the large (60S)ribosomal subunit, nearly identical to Rpl14Bpand has similarity to rat L14 ribosomalprotein; rpl14a csh5 double null mutantexhibits synthetic slow growth 0.002570.04509 S000002491TVP23YDR084CuncharacterizedIntegral membrane protein localized to late Golgi vesiclesalong with the v-SNARE Tlg2p; green fluorescentprotein (GFP)-fusion protein localizes to thecytoplasm in a punctate pattern 0.002570.04509&radic&radic S000006246PUF2YPR042CverifiedMember of the PUF protein family, which is defined by thepresence of Pumilio homology domains thatconfer RNA binding activity; preferentiallybinds mRNAs encoding membrane-associatedproteins 0.002570.04509&radic S000004681PDS5YMR076CverifiedProtein required for establishment and maintenance of sisterchromatid condensation and cohesion,colocalizes with cohesin on chromosomes in aninterdependent manner, may function as aprotein-protein interaction scaffold 0.002560.04497&radic S000000416NGR1YBR212WverifiedRNA binding protein that negatively regulates growth rate;interacts with the 3' UTR of the mitochondrialporin (POR1) mRNA and enhances its degradation;overexpression impairs mitochondrial function;expressed in stationary phase 0.002570.04497&radic&radic&radic&radic S000004917YME2YMR302CverifiedIntegral inner mitochondrial membrane protein with similarityto exonucleases; mutants exhibit an increasedrate of mitochondrial DNA escape 0.002560.04463&radic S000002505GRX3YDR098CverifiedHydroperoxide and superoxide-radical responsiveglutathione-dependent oxidoreductase; monothiolglutaredoxin subfamily member along with Grx4pand Grx5p; protects cells from oxidative damage 0.002530.04439&radic&radic&radic S000005152YNL208WUncharacterizedHypothetical protein 0.002520.04439 S000003236PEX31YGR004WverifiedPeroxisomal integral membrane protein, involved in negativeregulation of peroxisome size; partiallyfunctionally redundant with Pex30p and Pex32p;probably acts at a step downstream of stepsmediated by Pex28p and Pex29p 0.002530.04439&radic&radic&radic S000000147PIN4YBL051CverifiedProtein involved in G2/M phase progression and response to DNAdamage, interacts with Rad53p; contains an RNArecognition motif, a nuclear localizationsignal, and several SQ/TQ cluster domains;hyperphosphorylated in response to DNA damage 0.00250.04402&radic&radic&radic S000002240RPL13AYDL082WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl13Bp; not essential forviability; has similarity to rat L13 ribosomalprotein 0.002490.04391 S000000945DDI1YER143WverifiedDNA damage-inducible v-SNARE binding protein, contains aubiquitin-associated (UBA) domain, may act as anegative regulator of constitutive exocytosis,may play a role in S-phase checkpoint control 0.002490.04391 S000004881PRP24YMR268CverifiedSplicing factor that reanneals U4 and U6 snRNPs duringspliceosome recycling 0.002480.04376&radic&radic&radic&radic&radic S000000322TEF2YBR118WverifiedTranslational elongation factor EF-1 alpha; also encoded byTEF1; functions in the binding reaction ofaminoacyl-tRNA (AA-tRNA) to ribosomes 0.002390.04208 S000002946PAD1YDR538WverifiedPhenylacrylic acid decarboxylase, confers resistance tocinnamic acid, decarboxylates aromaticcarboxylic acids to the corresponding vinylderivatives 0.002380.04208&radic S000005029MKT1YNL085WverifiedProtein that forms a complex with Pbp1p that may mediateposttranscriptional regulation of HOendonuclease; involved in propagation of M2dsRNA satellite of L-A virus 0.002360.04186 S000005711GSP2YOR185CverifiedGTP binding protein (mammalian Ranp homolog) involved in themaintenance of nuclear organization, RNAprocessing and transport; interacts withKap121p, Kap123p and Pdr6p (karyophilin betas);Gsp1p homolog that is not required forviability 0.002360.04186&radic&radic S000002469LCB2YDR062WverifiedComponent of serine palmitoyltransferase, responsible alongwith Lcb1p for the first committed step insphingolipid synthesis, which is thecondensation of serine with palmitoyl-CoA toform 3-ketosphinganine 0.002310.04098&radic&radic S000000160PRX1YBL064CverifiedMitochondrial peroxiredoxin (1-Cys Prx) with thioredoxinperoxidase activity, has a role in reduction ofhydroperoxides; induced during respiratorygrowth and under conditions of oxidative stress 0.00230.04077&radic&radic&radic&radic&radic S000002211PBP4YDL053CverifiedPbp1p binding protein, interacts strongly with Pab1p-bindingprotein 1 (Pbp1p) in the yeast two-hybridsystem; also interacts with Lsm12p in acopurification assay 0.002290.04077&radic S000003628HPR5YJL092WverifiedDNA helicase and DNA-dependent ATPase involved in DNA repair,required for proper timing of commitment tomeiotic recombination and the transition fromMeiosis I to Meiosis II; potential Cdc28psubstrate 0.002290.04064&radic S000004585NAB6YML117WuncharacterizedPutative RNA-binding protein, based on computational analysisof large-scale protein-protein interaction data 0.002280.04057&radic S000005487RPL25YOL127WverifiedPrimary rRNA-binding ribosomal protein component of the large(60S) ribosomal subunit, has similarity to E.coli L23 and rat L23a ribosomal proteins; bindsto 26S rRNA via a conserved C-terminal motif 0.002280.04055 S000003572TAD2YJL035CverifiedSubunit of tRNA-specific adenosine-34 deaminase, forms aheterodimer with Tad3p that converts adenosineto inosine at the wobble position of severaltRNAs 0.002250.04009&radic S000000307SIF2YBR103WverifiedWD40 repeat-containing subunit of the Set3C histone deacetylasecomplex, which represses early/middlesporulation genes; antagonizes telomericsilencing; binds specifically to the Sir4pN-terminus 0.002230.03944&radic S000003060NUP145YGL092WverifiedEssential nucleoporin, catalyzes its own cleavage in vivo togenerate a C-terminal fragment that assemblesinto the Nup84p subcomplex of the nuclear porecomplex, and an N-terminal fragment of unknownfunction that is homologous to Nup100p 0.002220.03944&radic S000004723SPC24YMR117CverifiedComponent of the evolutionarily conservedkinetochore-associated Ndc80 complex(Ndc80p-Nuf2p-Spc24p-Spc25p); involved inchromosome segregation, spindle checkpointactivity and kinetochore clustering 0.002190.03911 S000002773ESF1YDR365CverifiedNucleolar protein involved in pre-rRNA processing; depletioncauses severely decreased 18S rRNA levels 0.002170.03887&radic&radic&radic&radic&radic&radic&radic S000003062PAN2YGL094CverifiedEssential subunit of the Pan2p-Pan3p poly(A)-ribonucleasecomplex, which acts to control poly(A) taillength and regulate the stoichiometry andactivity of postreplication repair complexes 0.002170.03861 S000001919PES4YFR023WverifiedPoly(A) binding protein, suppressor of DNA polymerase epsilonmutation, similar to Mip6p 0.002170.03861&radic&radic&radic S000003639GSM1YJL103CuncharacterizedPutative zinc cluster protein of unknown function; proposed tobe involved in the regulation of energymetabolism, based on patterns of expression andsequence analysis 0.002170.03861&radic S000004416SPP382YLR424WverifiedEssential protein that forms a dimer with Ntr2p; also forms atrimer, with Ntr2p and Prp43p, that is involvedin spliceosome disassembly; found also in amultisubunit complex with the splicing factorClf1p; suppressor of prp38-1 mutation 0.002150.03858&radic S000003874RSM7YJR113CverifiedMitochondrial ribosomal protein of the small subunit, hassimilarity to E. coli S7 ribosomal protein 0.002150.03854 S000000542SRO9YCL037CverifiedCytoplasmic RNA-binding protein that associates withtranslating ribosomes; involved in hemeregulation of Hap1p as a component of the HMCcomplex, also involved in the organization ofactin filaments; contains a La motif 0.002130.0382&radic&radic&radic&radic S000005130UBP10YNL186WverifiedUbiquitin-specific protease that deubiquitinatesubiquitin-protein moieties; may regulatesilencing by acting on Sir4p; involved inposttranscriptionally regulating Gap1p andpossibly other transporters; primarily locatedin the nucleus 0.002120.03813&radic&radic S000004989YIP3YNL044WverifiedProtein localized to COPII vesicles, proposed to be involved inER to Golgi transport; interacts with membersof the Rab GTPase family and Yip1p; alsointeracts with Rtn1p 0.002110.03804 S000003454PET54YGR222WverifiedProtein required for splicing of the COX1 intron AI5 beta; alsospecifically required, together with Pet122pand Pet494p, for translation of the COX3 mRNA;located in the mitochondrial inner membrane 0.002110.03804 S000003851JSN1YJR091CverifiedMember of the Puf family of RNA-binding proteins, interactswith mRNAs encoding membrane-associatedproteins; overexpression suppresses a tub2-150mutation and causes increased sensitivity tobenomyl in wild-type cells 0.002110.0378&radic S000004415ATG17YLR423CverifiedProtein that interacts with and is required for activation ofApg1p protein kinase; involved in autophagy butnot in the Cvt (cytoplasm to vacuole targeting)pathway 0.002060.03696 S000004429YLR437CUncharacterizedPutative protein of unknown function; epitope tagged protein localizes to the cytoplasm 0.002060.03696 S000004041FCF2YLR051CverifiedEssential nucleolar protein involved in the early steps of 35SrRNA processing; interacts with Faf1p; memberof a transcriptionally co-regulated set ofgenes called the RRB regulon 0.002060.03696&radic&radic&radic S000000159KIP1YBL063WverifiedKinesin-related motor protein required for mitotic spindleassembly and chromosome segregation;functionally redundant with Cin8p 0.002050.03696&radic&radic&radic&radic S000002452RPC11YDR045CverifiedRNA polymerase III subunit C11; mediates pol III RNA cleavageactivity and is important for termination oftranscription 0.002040.03693 S000003557BBC1YJL020CverifiedProtein possibly involved in assembly of actin patches;interacts with an actin assembly factor Las17pand with the SH3 domains of Type I myosinsMyo3p and Myo5p; localized predominantly tocortical actin patches 0.002040.03666 S000003367PRE9YGR135Wverified20S proteasome beta-type subunit; the only nonessential 20Ssubunit 0.002030.03666&radic&radic&radic S000000238HMT1YBR034CverifiedNuclear SAM-dependent mono- and asymmetric argininedimethylating methyltransferase that modifieshnRNPs, including Npl3p and Hrp1p, thusfacilitating nuclear export of these proteins;required for viability of npl3 mutants 0.002040.03666&radic&radic S000004187SIK1YLR197WverifiedEssential evolutionarily-conserved nucleolar protein componentof the box C/D snoRNP complexes that direct2'-O-methylation of pre-rRNA during itsmaturation; overexpression causes spindleorientation defects 0.002020.03643&radic&radic&radic&radic&radic S000006253ATG11YPR049CverifiedPeripheral membrane protein required for delivery ofaminopeptidase I (Lap4p) to the vacuole in thecytoplasm-to-vacuole targeting pathway; alsorequired for peroxisomal degradation(pexophagy) 0.0020.03607 S000001406TID3YIL144WverifiedComponent of the evolutionarily conservedkinetochore-associated Ndc80 complex(Ndc80p-Nuf2p-Spc24p-Spc25p); conservedcoiled-coil protein involved in chromosomesegregation, spindle checkpoint activity,kinetochore assembly and clustering 0.0020.03607&radic S000000439YBR235WUncharacterizedPutative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene 0.001970.03581&radic&radic&radic&radic S000002377YDL218WUncharacterizedHypothetical protein 0.001970.03574 S000003090NAB2YGL122CverifiedNuclear polyadenylated RNA-binding protein; autoregulates mRNAlevels; related to human hnRNPs; has nuclearlocalization signal sequence that binds toKap104p; required for poly(A) tail lengthcontrol and nuclear mRNA export &radic0.001970.03553&radic&radic S000000834FIR1YER032WverifiedProtein involved in 3' mRNA processing, interacts with Ref2p;potential Cdc28p substrate &radic0.001940.03524&radic&radic&radic&radic S000004165CBF5YLR175WverifiedPseudouridine synthase catalytic subunit of box H/ACA smallnucleolar ribonucleoprotein particles(snoRNPs), acts on both large and small rRNAsand on snRNA U2 0.001930.03506&radic&radic&radic&radic&radic&radic S000003871YMR1YJR110WverifiedPhosphatidylinositol 3-phosphate [PI(3)P] phosphatase,regulates the localization and levels ofPI(3)P; involved in cytoplasm to vacuole (CVT)transport; has similarity to the conservedmyotubularin dual specificity phosphatasefamily 0.001890.03428 S000001354YIL092WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus 0.00190.03428&radic S000000920SHO1YER118CverifiedTransmembrane osmosensor, participates in activation of boththe Cdc42p- and MAP kinase-dependentfilamentous growth pathway and thehigh-osmolarity glycerol response pathway 0.001890.03428 S000003360UTP8YGR128CverifiedNucleolar protein required for export of tRNAs from thenucleus; also copurifies with the small subunit(SSU) processome containing the U3 snoRNA thatis involved in processing of pre-18S rRNA 0.001860.03324&radic&radic&radic&radic&radic S000002979SCL1YGL011CverifiedAlpha subunit of the 20S core complex of the 26S proteasomeinvolved in the degradation of ubiquitinatedsubstrates; essential for growth; detected inthe mitochondria 0.001850.03324&radic&radic&radic&radic S000006124TPK2YPL203WverifiedSubunit of cytoplasmic cAMP-dependent protein kinase, whichcontains redundant catalytic subunits Tpk1p,Tpk2p, and Tpk3p and regulatory subunit Bcy1p;promotes vegetative growth in response tonutrients; activates filamentous growth 0.001830.03324&radic&radic&radic&radic S000000776RML2YEL050CverifiedMitochondrial ribosomal protein of the large subunit, hassimilarity to E. coli L2 ribosomal protein;fat21 mutant allele causes inability to utilizeoleate and may interfere with activity of theAdr1p transcription factor 0.001850.03324&radic&radic&radic&radic S000002707BFR2YDR299WverifiedEssential protein possibly involved in secretion; multicopysuppressor of sensitivity to Brefeldin A 0.001820.03306&radic&radic&radic&radic&radic S000000100UTP20YBL004WverifiedComponent of the small-subunit (SSU) processome, which isinvolved in the biogenesis of the 18S rRNA 0.00180.03276&radic&radic&radic&radic S000005398PRE6YOL038Wverified20S proteasome alpha-type subunit; green fluorescent protein(GFP)-fusion protein relocates from the cytosolto the mitochondrial outer surface uponoxidative stress 0.001780.03229&radic&radic&radic S000004915ADE4YMR300CverifiedPhosphoribosylpyrophosphate amidotransferase (PRPPAT;amidophosphoribosyltransferase), catalyzesfirst step of the 'de novo' purine nucleotidebiosynthetic pathway 0.001790.03229&radic&radic S000001177YCK1YHR135CverifiedPalmitoylated, plasma membrane-bound casein kinase I isoform;shares redundant functions with Yck2p inmorphogenesis, proper septin assembly,endocytic trafficking; provides an essentialfunction overlapping with that of Yck2p 0.001770.03204&radic&radic S000005361PHO80YOL001WverifiedCyclin, negatively regulates phosphate metabolism;Pho80p-Pho85p (cyclin-CDK complex)phosphorylates Pho4p and Swi5p; deletion ofPHO80 leads to aminoglycoside supersensitivity;truncated form of PHO80 affects vacuoleinheritance 0.00170.0305&radic&radic&radic S000002716SRB7YDR308CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation; target of theglobal repressor Tup1p 0.001460.02097&radic&radic&radic&radic&radic&radic S000000680TUP1YCR084CverifiedGeneral repressor of transcription, forms complex with Cyc8p,involved in the establishment of repressivechromatin structure through interactions withhistones H3 and H4, appears to enhanceexpression of some genes 0.001430.02&radic&radic S000002769BCP1YDR361CverifiedEssential protein involved in nuclear export of Mss4p, which isa lipid kinase that generatesphosphatidylinositol 4,5-biphosphate and playsa role in actin cytoskeleton organization andvesicular transport 0.001420.01969&radic&radic&radic&radic&radic S000002599HST4YDR191WverifiedMember of the Sir2 family of NAD(+)-dependent proteindeacetylases; involved along with Hst3p insilencing at telomeres, cell cycle progression,radiation resistance, genomic stability andshort-chain fatty acid metabolism 0.00140.01883&radic&radic&radic&radic&radic S000006010RLM1YPL089CverifiedMADS-box transcription factor, component of the protein kinaseC-mediated MAP kinase pathway involved in themaintenance of cell integrity; phosphorylatedand activated by the MAP-kinase Slt2p 0.001390.01872&radic&radic&radic S000001870EPL1YFL024CverifiedComponent of NuA4, which is an essential histone H4/H2Aacetyltransferase complex; homologous toDrosophila Enhancer of Polycomb 0.001390.0185&radic&radic&radic S000004889DSK2YMR276WverifiedNuclear-enriched ubiquitin-like polyubiquitin-binding protein,required for spindle pole body (SPB)duplication and for transit through the G2/Mphase of the cell cycle, involved inproteolysis, interacts with the proteasome 0.001380.01838&radic&radic&radic&radic&radic&radic S000005256RFA2YNL312WverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 0.001360.01756&radic&radic&radic S000004166RFX1YLR176CverifiedProtein involved in DNA damage and replication checkpointpathway; recruits repressors Tup1p and Cyc8p topromoters of DNA damage-inducible genes;similar to a family of mammalian DNA bindingRFX1-4 proteins 0.001350.01724&radic&radic&radic&radic S000001239UTP9YHR196WverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.001350.01724&radic&radic&radic S000004045SPT8YLR055CverifiedSubunit of the SAGA transcriptional regulatory complex but notpresent in SAGA-like complex SLIK/SALSA,required for SAGA-mediated inhibition at somepromoters 0.001340.01685&radic&radic&radic&radic&radic S000000148SAS3YBL052CverifiedHistone acetyltransferase catalytic subunit of NuA3 complexthat acetylates histone H3, involved intranscriptional silencing; homolog of themammalian MOZ proto-oncogene; sas3 gcn5 doublemutation confers lethality 0.001340.01685&radic&radic&radic&radic&radic S000003712SWI3YJL176CverifiedSubunit of the SWI/SNF chromatin remodeling complex, whichregulates transcription by remodelingchromosomes; required for transcription of manygenes, including ADH1, ADH2, GAL1, HO, INO1 andSUC2 0.001340.01685&radic&radic&radic S000000735GCN4YEL009CverifiedTranscriptional activator of amino acid biosynthetic genes inresponse to amino acid starvation; expressionis tightly regulated at both thetranscriptional and translational levels 0.001340.01685&radic&radic&radic&radic&radic&radic S000002341LYS20YDL182WverifiedHomocitrate synthase isozyme, catalyzes the condensation ofacetyl-CoA and alpha-ketoglutarate to formhomocitrate, which is the first step in thelysine biosynthesis pathway; highly similar tothe other isozyme, Lys21p 0.001340.01685&radic&radic S000005198YNL254CUncharacterizedHypothetical protein 0.001340.01685&radic&radic&radic S000005677RPB2YOR151CverifiedRNA polymerase II second largest subunit B150, part of centralcore; similar to bacterial beta subunit 0.001330.01665&radic&radic&radic&radic S000005996GCR1YPL075WverifiedTranscriptional activator of genes involved in glycolysis;DNA-binding protein that interacts andfunctions with the transcriptional activatorGcr2p 0.001330.01665&radic&radic&radic&radic&radic S000003041HSF1YGL073WverifiedTrimeric heat shock transcription factor, activates multiplegenes in response to stresses that includehyperthermia; recognizes variable heat shockelements (HSEs) consisting of inverted NGAANrepeats; posttranslationally regulated 0.001330.01657&radic&radic&radic&radic&radic&radic S000002494RRP1YDR087CverifiedEssential evolutionarily conserved nucleolar protein necessaryfor biogenesis of 60S ribosomal subunits andprocessing of pre-rRNAs to mature rRNAs,associated with several distinct 66Spre-ribosomal particles 0.001330.01657&radic&radic&radic&radic S000004391BDF1YLR399CverifiedProtein involved in transcription initiation at TATA-containingpromoters; associates with the basaltranscription factor TFIID; contains twobromodomains; corresponds to the C-terminalregion of mammalian TAF1; redundant with Bdf2p 0.001330.01657&radic&radic&radic S000000122LSM2YBL026WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.001320.0164&radic&radic&radic&radic S000000842GLN3YER040WverifiedTranscriptional activator of genes regulated by nitrogencatabolite repression (NCR), localization andactivity regulated by quality of nitrogensource 0.001320.0164&radic&radic&radic&radic&radic S000005768SSP2YOR242CverifiedSporulation specific protein that localizes to the spore wall;required for sporulation at a point aftermeiosis II and during spore wall formation;SSP2 expression is induced midway in meiosis 0.001320.0164&radic&radic&radic S000006305SNT309YPR101WverifiedComponent of NineTeen complex (NTC) containing Prp19p involvedin mRNA splicing, interacts physically andgenetically with Prp19p 0.001320.0163&radic&radic S000005006GCD10YNL062CverifiedSubunit of tRNA (1-methyladenosine) methyltransferase withGcd14p, required for the modification of theadenine at position 58 in tRNAs, especiallytRNAi-Met; first identified as a negativeregulator of GCN4 expression 0.001320.01623&radic&radic S000002722RAD34YDR314CverifiedProtein involved in nucleotide excision repair (NER);homologous to RAD4 0.001320.01623&radic&radic&radic S000005150RTT106YNL206CverifiedProtein with a role in regulation of Ty1 transposition 0.001320.01623&radic&radic&radic&radic&radic&radic S000006331YPR127WUncharacterizedHypothetical protein 0.001320.01623&radic&radic&radic&radic&radic S000002711RSC3YDR303CverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; essential gene required forregulation of ribosomal protein genes and thecell wall/stress response; highly similar toRsc30p 0.001310.01611&radic&radic&radic&radic S000002413SOK1YDR006CverifiedProtein whose overexpression suppresses the growth defect ofmutants lacking protein kinase A activity;involved in cAMP-mediated signaling; localizedto the nucleus; similar to the mousetestis-specific protein PBS13 0.001310.01607&radic&radic S000004734SAS2YMR127CverifiedHistone acetyltransferase (HAT) catalytic subunit of the SAScomplex (Sas2p-Sas4p-Sas5p), which acetylatesfree histones and nucleosomes and regulatestranscriptional silencing; member of theMYSTacetyltransferase family 0.001310.01601&radic&radic S000001923ECO1YFR027WverifiedAcetyltransferase required for the establishment of sisterchromatid cohesion during DNA replication, butnot for its maintenance during G2 and M phases;also required for postreplicative double-strandbreak repair; interacts with Chl1p 0.00130.0158&radic&radic&radic S000005159IES2YNL215WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.00130.0158&radic&radic&radic&radic&radic S000005801RIM20YOR275CverifiedProtein involved in proteolytic activation of Rim101p inresponse to alkaline pH; member of thePalA/AIP1/Alix family; interacts with theESCRT-III subunits Snf7p, suggesting arelationship between the response to pH andmultivesicular body formation 0.00130.0158&radic&radic S000002661MET32YDR253CverifiedZinc-finger DNA-binding protein, involved in regulatingexpression of the methionine biosyntheticgenes, similar to Met31p 0.00130.0158&radic&radic&radic&radic&radic S000005756WTM1YOR230WverifiedTranscriptional repressor involved in regulation of meiosis andsilencing; contains WD repeats 0.00130.0158&radic&radic&radic S000001632DBR1YKL149CverifiedRNA lariat debranching enzyme, involved in intron turnover;required for efficient Ty1 transposition 0.00130.01576&radic&radic&radic&radic&radic S000001083SRB2YHR041CverifiedGeneral transcription factor, subunit of the RNA polymerase IImediator complex; associates with corepolymerase subunits to form the RNA polymeraseII holoenzyme; involved in telomere maintenance 0.001290.01564&radic&radic S000002886SNM1YDR478WverifiedSubunit of RNase MRP, which cleaves pre-rRNA; not sharedbetween Rnase MRP and nuclear Rnase P, incontrast to all other Rnase MRP proteinsubunits; binds to the NME1 RNA subunit ofRnase MRP 0.001290.01564&radic&radic S000005242CLA4YNL298WverifiedCdc42p activated signal transducing kinase of the PAK(p21-activated kinase) family, involved inseptin ring assembly and cytokinesis; directlyphosphorylates septins Cdc3p and Cdc10p; otheryeast PAK family members are Ste20p and Skm1p 0.001290.01556&radic&radic&radic&radic S000005785RPT4YOR259CverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; required for spindlepole body duplication; localized mainly to thenucleus throughout the cell cycle 0.001290.01547&radic&radic&radic&radic&radic&radic S000000427TDP1YBR223CverifiedTyrosyl-DNA Phosphodiesterase I, hydrolyzes 3'-phosphotyrosylbonds to generate 3'-phosphate DNA andtyrosine, involved in the repair of DNA lesionscreated by topoisomerase I 0.001290.01547&radic&radic&radic&radic&radic S000006373JIP5YPR169WuncharacterizedNucleolar protein of unknown function, exhibits a physicalinteraction with Bre1p 0.001280.01518&radic&radic&radic&radic&radic S000001001YAP3YHL009CverifiedBasic leucine zipper (bZIP) transcription factor 0.001280.01518&radic&radic&radic&radic S000004093CDC45YLR103CverifiedDNA replication initiation factor; recruited to MCM pre-RCcomplexes at replication origins; promotesrelease of MCM from Mcm10p, recruits elongationmachinery; mutants in human homolog may causevelocardiofacial and DiGeorge syndromes 0.001280.01518&radic&radic&radic&radic&radic S000005885HAP5YOR358WverifiedSubunit of the heme-activated, glucose-repressed Hap2/3/4/5CCAAT-binding complex, a transcriptionalactivator and global regulator of respiratorygene expression; required for assembly and DNAbinding activity of the complex 0.001280.01518&radic&radic&radic&radic&radic&radic S000006049TBF1YPL128CverifiedTelobox-containing general regulatory factor; binds to TTAGGGrepeats within subtelomeric anti-silencingregions (STARs) and possibly throughout thegenome and mediates their insulating capacityby blocking silent chromatin propagation 0.001280.01511&radic&radic&radic&radic&radic S000000678AHC2YCR082WuncharacterizedProtein of unknown function, putative transcriptionalregulator; proposed to be a Ada Histoneacetyltransferase complex component; GFP taggedprotein is localized to the cytoplasm andnucleus 0.001280.01511&radic&radic S000002580ARG82YDR173CverifiedInositol polyphosphate multikinase (IPMK), sequentiallyphosphorylates Ins(1,4,5)P3 to formIns(1,3,4,5,6)P5; putative nuclear lipidinositol PI3-kinase; regulates arginine-,phosphate-, and nitrogen-responsive genes 0.001280.0151&radic&radic&radic&radic&radic S000005508SPT20YOL148CverifiedSubunit of the SAGA transcriptional regulatory complex,involved in maintaining the integrity of thecomplex 0.001280.01506&radic&radic S000000449ISW1YBR245CverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPase thatforms a complex with Ioc2p and Ioc4p toregulate transcription elongation, and acomplex with Ioc3p to repress transcriptioninitiation 0.001280.01506&radic&radic&radic S000005233PCL1YNL289WverifiedPho85 cyclin of the Pcl1,2-like subfamily, involved in entryinto the mitotic cell cycle and regulation ofmorphogenesis, localizes to sites of polarizedcell growth 0.001280.01505&radic&radic&radic S000002621UPC2YDR213WverifiedSterol regulatory element binding protein, inducestranscription of sterol transport andbiosynthetic genes; involved in the anaerobicinduction of DAN/TIR mannoproteins andseripauperins; binucleate zinc cluster protein;Ecm22p homolog 0.001270.01502&radic&radic&radic&radic&radic&radic S000004088CHA4YLR098CverifiedDNA binding transcriptional activator, mediatesserine/threonine activation of the catabolicL-serine (L-threonine) deaminase (CHA1);Zinc-finger protein with Zn[2]-Cys[6]fungal-type binuclear cluster domain 0.001270.01488&radic&radic&radic&radic S000003925RTT109YLL002WverifiedProtein with a role in regulation of Ty1 transposition 0.001270.01488&radic&radic&radic S000006390PZF1YPR186CverifiedTranscription factor IIIA (TFIIIA), essential protein with nineC2H2 Zn-fingers, binds the 5S rRNA gene throughthe zinc finger domain and directs assembly ofa multiprotein initiation complex for RNApolymerase III; also binds DNA 0.001270.01488&radic&radic&radic S000003162HOS2YGL194CverifiedHistone deacetylase required for gene activation via specificdeacetylation of lysines in H3 and H4 histonetails; subunit of the Set3 complex, ameiotic-specific repressor of sporulationspecific genes that contains deacetylaseactivity 0.001270.01488&radic&radic&radic&radic&radic S000006003MOT1YPL082CverifiedEssential abundant protein involved in regulation oftranscription, removes Spt15p (TBP) from DNAvia its C-terminal ATPase activity, forms acomplex with TBP that binds TATA DNA with highaffinity but with altered specificity 0.001270.01488&radic&radic&radic&radic S000005755WTM2YOR229WverifiedTranscriptional repressor involved in regulation of meiosis andsilencing; contains WD repeats 0.001270.01482&radic&radic&radic&radic S000002997CGR1YGL029WverifiedProtein involved in nucleolar integrity and processing of thepre-rRNA for the 60S ribosome subunit;transcript is induced in response to cytotoxicstress but not genotoxic stress 0.001270.01482&radic&radic&radic&radic S000004096MDN1YLR106CverifiedHuge dynein-related AAA-type ATPase (midasin), forms extendedpre-60S particle with the Rix1 complex(Rix1p-Ipi1p-Ipi3p), may mediate ATP-dependentremodeling of 60S subunits and subsequentexport from nucleoplasm to cytoplasm 0.001260.01473&radic&radic&radic&radic S000004035STU2YLR045CverifiedMicrotubule-associated protein (MAP) of the XMAP215/Dis1family; regulates microtubule dynamics duringspindle orientation and metaphase chromosomealignment; interacts with spindle pole bodycomponent Spc72p 0.001270.01473&radic&radic&radic&radic S000005582NOB1YOR056CverifiedEssential nuclear protein involved in proteasome maturation andsynthesis of 40S ribosomal subunits; requiredfor cleavage of the 20S pre-rRNA to generatethe mature 18S rRNA 0.001260.01463&radic&radic&radic&radic&radic S000005176CSL4YNL232WverifiedSubunit of the exosome, which is an essential complex presentin both nucleus and cytoplasm that mediates RNAprocessing and degradation 0.001260.01463&radic&radic&radic&radic&radic S000006044RNY1YPL123CverifiedRNAse; member of the T(2) family of endoribonucleases 0.001260.01463&radic&radic&radic&radic S000000316CYC8YBR112CverifiedGeneral transcriptional co-repressor, acts together with Tup1p;also acts as part of a transcriptionalco-activator complex that recruits the SWI/SNFand SAGA complexes to promoters 0.001260.01461&radic&radic S000002803SXM1YDR395WverifiedNuclear transport factor (karyopherin) involved in proteintransport between the cytoplasm andnucleoplasm; similar to Nmd5p, Cse1p, Lph2p,and the human cellular apoptosis susceptibilityprotein, CAS1 0.001260.01456&radic&radic&radic&radic S000002264PHO2YDL106CverifiedHomeobox transcription factor; regulatory targets include genesinvolved in phosphate metabolism; bindscooperatively with Pho4p to the PHO5 promoter;phosphorylation of Pho2p facilitatesinteraction with Pho4p 0.001260.01456&radic&radic S000004735ECM16YMR128WverifiedEssential DEAH-box ATP-dependent RNA helicase specific to theU3 snoRNP, predominantly nucleolar indistribution, required for 18S rRNA synthesis 0.001260.01456&radic&radic S000002228BDF2YDL070WverifiedProtein involved in transcription initiation at TATA-containingpromoters; associates with the basaltranscription factor TFIID; contains twobromodomains; corresponds to the C-terminalregion of mammalian TAF1; redundant with Bdf1p 0.001260.01448&radic&radic S000005098YCK2YNL154CverifiedPalmitoylated, plasma membrane-bound casein kinase I isoform;shares redundant functions with Yck1p inmorphogenesis, proper septin assembly,endocytic trafficking; provides an essentialfunction overlapping with that of Yck1p 0.001250.0144&radic&radic&radic S000000175NUP170YBL079WverifiedAbundant subunit of the nuclear pore complex (NPC), requiredfor proper localization of specificnucleoporins within the NPC, involved innuclear envelope permeability and in chromosomesegregation, has similarity to Nup157p 0.001250.0144&radic&radic&radic&radic S000005621RKI1YOR095CverifiedRibose-5-phosphate ketol-isomerase, catalyzes theinterconversion of ribose 5-phosphate andribulose 5-phosphate in the pentose phosphatepathway; participates in pyridoxinebiosynthesis 0.001250.01437&radic&radic S000005551HST3YOR025WverifiedMember of the Sir2 family of NAD(+)-dependent proteindeacetylases; involved along with Hst4p intelomeric silencing, cell cycle progression,radiation resistance, genomic stability andshort-chain fatty acid metabolism 0.001250.01437&radic&radic&radic&radic S000000392NTC20YBR188CverifiedMember of a complex, including Prp19p, that binds to thespliceosome; required for pre-mRNA splicing 0.001250.01431&radic&radic&radic&radic&radic&radic S000003436ADE3YGR204WverifiedCytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase,involved in single carbon metabolism andrequired for biosynthesis of purines,thymidylate, methionine, and histidine 0.001250.01418&radic&radic S000003262POP6YGR030CverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends 0.001250.01418&radic&radic&radic&radic S000002786LSM6YDR378CverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.001250.01418&radic&radic&radic&radic&radic S000001492MRT4YKL009WverifiedProtein involved in mRNA turnover and ribosome assembly,localizes to the nucleolus 0.001250.01418&radic&radic&radic&radic&radic S000006050TAF14YPL129WverifiedSubunit (30 kDa) of TFIID, TFIIF, and SWI/SNF complexes,involved in RNA polymerase II transcriptioninitiation and in chromatin modification,contains a YEATS domain 0.001240.01412&radic&radic&radic&radic S000006312RPN7YPR108WverifiedEssential, non-ATPase regulatory subunit of the 26S proteasome,similar to another S. cerevisiae regulatorysubunit, Rpn5p, as well as to mammalianproteasome subunits 0.001240.01408&radic&radic&radic&radic&radic S000003908HMS2YJR147WverifiedProtein with similarity to heat shock transcription factors;overexpression suppresses the pseudohyphalfilamentation defect of a diploid mep1 mep2homozygous null mutant 0.001240.01408&radic&radic S000000560KAR4YCL055WverifiedTranscription factor required for gene regulation in repsonseto pheromones; also required during meiosis;exists in two forms, a slower-migrating formmore abundant during vegetative growth and afaster-migrating form induced by pheromone 0.001240.01408&radic&radic&radic&radic S000001933RSC8YFR037CverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; essential for viability andmitotic growth; homolog of SWI/SNF subunitSwi3p, but unlike Swi3p, does not activatetranscription of reporters 0.001240.01408&radic&radic&radic S000003050YGL082WUncharacterizedHypothetical protein 0.001240.01401&radic&radic&radic&radic S000004840TAF7YMR227CverifiedTFIID subunit (67 kDa), involved in RNA polymerase IItranscription initiation 0.001240.01395&radic&radic&radic&radic S000004076SMC4YLR086WverifiedSubunit of the condensin complex, which reorganizes chromosomesduring cell division, forms a stable complexwith Smc2p that has ATP-hydrolyzing andDNA-binding activity and promotes knotting ofcircular DNA; potential Cdc28p substrate 0.001240.01395&radic&radic&radic&radic&radic S000002676MSW1YDR268WverifiedMitochondrial tryptophanyl-tRNA synthetase 0.001240.01395&radic&radic&radic S000001505CDC16YKL022CverifiedSubunit of the anaphase-promoting complex/cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition; required forsporulation 0.001240.01395&radic&radic&radic&radic S000006337SPN1YPR133CverifiedProtein that interacts with Spt6p and copurifies with Spt5p andRNA polymerase II, probable transcriptionalelongation factor; metazoan homologs contain anacidic N terminus; mutations in the gene conferan Spt- phenotype 0.001230.01384&radic&radic&radic&radic&radic S000006372NUT2YPR168WverifiedComponent of the RNA polymerase II mediator complex, which isrequired for transcriptional activation andalso has a role in basal transcription 0.001230.01384&radic&radic&radic&radic&radic&radic S000005989YPL068CUncharacterizedHypothetical protein 0.001240.01384&radic&radic&radic&radic S000002981PDR1YGL013CverifiedZinc cluster protein that is a master regulator involved inrecruiting other zinc cluster proteins topleiotropic drug response elements (PDREs) tofine tune the regulation of multidrugresistance genes 0.001240.01384&radic&radic&radic&radic S000005140YNL196CUncharacterizedSporulation-specific protein with a leucine zipper motif 0.001230.01384&radic&radic S000004168TFS1YLR178CverifiedCarboxypeptidase Y inhibitor, function requires acetylation bythe NatB N-terminal acetyltransferase;phosphatidylethanolamine-binding proteininvolved in protein kinase A signaling pathway 0.001240.01384&radic&radic&radic&radic&radic&radic S000002665SET7YDR257CverifiedNuclear protein that contains a SET-domain, which have beenshown to mediate methyltransferase activity inother proteins 0.001240.01384&radic&radic&radic&radic&radic&radic S000003322UTP22YGR090WuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.001230.01374&radic&radic&radic&radic&radic&radic S000001208PRP8YHR165CverifiedComponent of the U4/U6-U5 snRNP complex, involved in the secondcatalytic step of splicing 0.001230.01374&radic&radic S000000961BUR6YER159CverifiedProtein that forms a heterodimeric histone-fold NC2 generaltranscription regulator complex with Ydr1p thatbinds to TBP and represses RNA pol IItranscription during assembly of thepreinitiation complex, homologous to humanNC2alpha 0.001230.01374&radic&radic S000004265SMD2YLR275WverifiedCore Sm protein Sm D2; part of heteroheptameric complex (withSmb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D2 0.001230.01374&radic&radic&radic&radic&radic S000005083RLR1YNL139CverifiedSubunit of the THO complex, which is required for efficienttranscription elongation and involved intranscriptional elongation-associatedrecombination; required for LacZ RNA expressionfrom certain plasmids 0.001230.01374&radic&radic S000002490RRP8YDR083WverifiedNucleolar protein involved in rRNA processing, pre-rRNAcleavage at site A2; also involved in telomeremaintenance; mutation is synthetically lethalwith a gar1 mutation 0.001230.01368&radic&radic&radic&radic&radic S000005959MET31YPL038WverifiedZinc-finger DNA-binding protein, involved in regulatingexpression of the methionine biosyntheticgenes, similar to Met32p 0.001230.01368&radic&radic&radic&radic&radic&radic S000006175HFI1YPL254WverifiedAdaptor protein required for structural integrity of the SAGAcomplex, a histoneacetyltransferase-coactivator complex that isinvolved in global regulation of geneexpression through acetylation andtranscription functions 0.001230.01368&radic&radic&radic S000006037HOS3YPL116WverifiedTrichostatin A-insensitive homodimeric histone deacetylase(HDAC) with specificity in vitro for histonesH3, H4, H2A, and H2B; similar to Hda1p, Rpd3p,Hos1p, and Hos2p; deletion results in increasedhistone acetylation at rDNA repeats 0.001220.01349&radic&radic&radic&radic S000005732NOC2YOR206WverifiedProtein that forms a nucleolar complex with Mak21p that bindsto 90S and 66S pre-ribosomes, as well as anuclear complex with Noc3p that binds to 66Spre-ribosomes; both complexes mediateintranuclear transport of ribosomal precursors 0.001230.01349&radic&radic&radic&radic S000004298CDA1YLR307WverifiedChitin deacetylase, together with Cda2p involved in thebiosynthesis ascospore wall component,chitosan; required for proper rigidity of theascospore wall 0.001230.01349&radic&radic&radic S000005787RPN8YOR261CverifiedEssential, non-ATPase regulatory subunit of the 26S proteasome;has similarity to the human p40 proteasomalsubunit and to another S. cerevisiae regulatorysubunit, Rpn11p 0.001220.01349&radic&radic&radic&radic&radic S000004085IOC2YLR095CverifiedMember of a complex (Isw1b) with Isw1p and Ioc4p that exhibitsnucleosome-stimulated ATPase activity and actswithin coding regions to coordinatetranscription elongation with termination andprocessing, contains a PHD finger motif 0.001230.01349&radic&radic&radic&radic&radic&radic S000000564KRR1YCL059CverifiedEssential nucleolar protein required for the synthesis of 18SrRNA and for the assembly of 40S ribosomalsubunit 0.001230.01349&radic&radic&radic S000006048HHO1YPL127CverifiedHistone H1, a linker histone required for nucleosome packagingat restricted sites; suppresses DNA repairinvolving homologous recombination; notrequired for telomeric silencing, basaltranscriptional repression, or efficientsporulation 0.001220.01349&radic&radic&radic&radic&radic S000002572TRM82YDR165WverifiedSubunit of a tRNA methyltransferase complex composed of Trm8pand Trm82p that catalyzes 7-methylguanosinemodification of tRNA 0.001220.01338&radic&radic&radic&radic S000004560RAD10YML095CverifiedSingle-stranded DNA endonuclease (with Rad1p), cleavessingle-stranded DNA during nucleotide excisionrepair and double-strand break repair; subunitof Nucleotide Excision Repair Factor 1 (NEF1);homolog of human ERCC1 protein 0.001220.01338&radic&radic S000000457SRB6YBR253WverifiedEssentital subunit of the RNA polymerase II mediator complex;associates with core polymerase subunits toform the RNA polymerase II holoenzyme;essential for transcriptional regulation 0.001220.01338&radic&radic&radic&radic&radic S000005205ORC5YNL261WverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing 0.001220.01338&radic&radic&radic S000005440REX4YOL080CverifiedPutative RNA exonuclease possibly involved in pre-rRNAprocessing and ribosome assembly 0.001220.01338&radic&radic&radic&radic&radic S000005721SLK19YOR195WverifiedKinetochore-associated protein required for normal segregationof chromosomes in meiosis and mitosis;component of the FEAR regulatory network, whichpromotes Cdc14p release from the nucleolusduring anaphase; potential Cdc28p substrate 0.001220.01338&radic&radic&radic&radic S000005381DIS3YOL021CverifiedNucleolar exosome component, involved in rRNA processing andRNA degradation, binds Gsp1p/Ran and enhancesthe GEF activity of Srm1p, implicated inmitotic control, homologous to the E. coliRNase R of the RNase II family 0.001220.01338&radic&radic&radic&radic&radic&radic S000005750RPB8YOR224CverifiedRNA polymerase subunit ABC14.5, common to RNA polymerases I,II, and III 0.001210.01322&radic&radic&radic&radic S000005590YNG1YOR064CverifiedSubunit of the NuA3 histone acetyltransferase complex thatacetylates histone H3; has similarity to thehuman tumor suppressor ING1 0.001210.01322&radic&radic&radic&radic&radic&radic S000005313ALG12YNR030WverifiedAlpha-1,6-mannosyltransferase localized to the ER; responsiblefor the addition of the alpha-1,6 mannose todolichol-linked Man7GlcNAc2, acts in thedolichol pathway for N-glycosylation 0.001220.01322&radic S000000763RAD23YEL037CverifiedProtein with ubiquitin-like N terminus, recognizes and bindsdamaged DNA (with Rad4p) during nucleotideexcision repair; regulates Rad4p levels,subunit of Nuclear Excision Repair Factor 2(NEF2); homolog of human HR23A and HR23Bproteins 0.001220.01322&radic&radic&radic S000006067NOP53YPL146CverifiedNucleolar protein; involved in biogenesis of the 60S subunit ofthe ribosome; interacts with rRNA processingfactors Cbf5p and Nop2p; null mutant is viablebut growth is severely impaired 0.001210.01322&radic&radic S000006382PRP4YPR178WverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.001210.01322&radic&radic S000006125HRR25YPL204WverifiedProtein kinase involved in regulating diverse events includingvesicular trafficking, gene expression, DNArepair, and chromosome segregation; binds theCTD of RNA pol II; homolog of mammalian caseinkinase 1delta (CK1delta) 0.001220.01322&radic&radic&radic&radic&radic S000002890CWC21YDR482CverifiedComponent of a complex containing Cef1p, putatively involved inpre-mRNA splicing; may bind RNA; has similarityto S. pombe Cwf21p 0.001220.01322&radic&radic S000005388YAP7YOL028CverifiedPutative basic leucine zipper (bZIP) transcription factor 0.001210.01322&radic&radic&radic&radic&radic&radic S000003197SHE10YGL228WverifiedPutative glycosylphosphatidylinositol (GPI)-anchored protein ofunknown function; overexpression causes growtharrest 0.001210.01322&radic&radic&radic&radic S000004752YMR144WUncharacterizedPutative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene 0.001210.01316&radic&radic&radic S000003024SDS23YGL056CverifiedOne of two S. cerevisiae homologs (Sds23p and Sds24p) of theSchizosaccharomyces pombe Sds23 protein, whichgenetic studies have implicated inAPC/cyclosome regulation 0.001210.01316&radic&radic&radic&radic S000003335NOP7YGR103WverifiedNucleolar protein involved in rRNA processing and 60S ribosomalsubunit biogenesis; constituent of severaldifferent pre-ribosomal particles; required forexit from G0 and the initiation ofcell proliferation 0.001210.01309&radic&radic&radic&radic&radic S000000851TPA1YER049WuncharacterizedProtein of unknown function; interacts with Sup45p (eRF1),Sup35p (eRF3) and Pab1p; has a role intranslation termination efficiency, mRNApoly(A) tail length and mRNA stability 0.001210.01309&radic&radic&radic S000002632HTB1YDR224CverifiedOne of two nearly identical (see HTB2) histone H2B subtypesrequired for chromatin assembly and chromosomefunction; Rad6p-Bre1p-Lge1p mediatedubiquitination regulates transcriptionalactivation, meiotic DSB formation and H3methylation 0.001210.01309&radic&radic&radic S000000419HPC2YBR215WverifiedHighly charged, basic protein required for normal cell-cycleregulation of histone gene transcription;mutants display strong synthetic defects withsubunits of FACT, a complex that allows RNA PolII to elongate through nucleosomes 0.001210.01309&radic&radic&radic&radic&radic S000002704MHR1YDR296WverifiedProtein involved in homologous recombination in mitochondriaand in transcription regulation in nucleus;binds to activation domains of acidicactivators; required forrecombination-dependent mtDNA partitioning 0.001210.01299&radic&radic&radic&radic S000004190YKE2YLR200WverifiedSubunit of the heterohexameric Gim/prefoldin protein complexinvolved in the folding of alpha-tubulin,beta-tubulin, and actin 0.001210.01299&radic&radic&radic&radic S000000534BIK1YCL029CverifiedMicrotubule-associated protein, component of the interfacebetween microtubules and kinetochore, involvedin sister chromatid separation; essential inpolyploid cells but not in haploid or diploidcells; ortholog of mammalian CLIP-170 0.001210.01299&radic&radic&radic&radic&radic S000005933RRP12YPL012WverifiedProtein required for export of the ribosomal subunits;associates with the RNA components of thepre-ribosomes; contains HEAT-repeats 0.00120.0129&radic&radic&radic&radic&radic S000004927YMR310CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene 0.00120.0129&radic&radic&radic&radic&radic S000002499UBC13YDR092WverifiedUbiquitin-conjugating enzyme involved in the error-free DNApostreplication repair pathway; interacts withMms2p to assemble ubiquitin chains at the UbLys-63 residue; DNA damage triggersredistribution from the cytoplasm to thenucleus 0.00120.0129&radic S000002703HDA2YDR295CverifiedSubunit of a possibly tetrameric trichostatin A-sensitive classII histone deacetylase complex containing anHda1p homodimer and an Hda2p-Hda3p heterodimer;involved in telomere maintenance 0.00120.01268&radic&radic&radic&radic&radic&radic S000005626CRC1YOR100CverifiedMitochondrial inner membrane carnitine transporter, requiredfor carnitine-dependent transport of acetyl-CoAfrom peroxisomes to mitochondria during fattyacid beta-oxidation 0.00120.01268&radic&radic&radic&radic S000001107RRP3YHR065CverifiedProtein involved in rRNA processing; required for maturation ofthe 35S primary transcript of pre-rRNA and forcleavage leading to mature 18S rRNA; homologousto eIF-4a, which is a DEAD box RNA-dependentATPase with helicase activity 0.00120.01268&radic&radic&radic&radic S000006365SGV1YPR161CverifiedCyclin (Bur2p)-dependent protein kinase that functions intranscriptional regulation; phosphorylates thecarboxy-terminal domain of Rpo21p, which is thelargest subunit of RNA polymerase II; regulatedby Cak1p 0.00120.01268&radic&radic S000005985CWC27YPL064CverifiedComponent of a complex containing Cef1p, putatively involved inpre-mRNA splicing; has similarity to S. pombeCwf27p 0.00120.01268&radic&radic&radic&radic&radic&radic S000005945RMI1YPL024WverifiedInvolved in response to DNA damage; null mutants have increasedrates of recombination and delayed S phase;interacts physically and genetically with Sgs1p(RecQ family member) and Top3p (topoisomeraseIII) 0.00120.01268&radic&radic&radic S000003384RSR1YGR152CverifiedGTP-binding protein of the ras superfamily required for budsite selection, morphological changes inresponse to mating pheromone, and efficientcell fusion; localized to the plasma membrane;significantly similar to mammalian Rap GTPases 0.00120.01268&radic&radic&radic&radic S000006115DDC1YPL194WverifiedDNA damage checkpoint protein, part of a PCNA-like complexrequired for DNA damage response, required forpachytene checkpoint to inhibit cell cycle inresponse to unrepaired recombinationintermediates; potential Cdc28p substrate 0.00120.01268&radic&radic S000001897LOC1YFR001WverifiedNuclear protein involved in asymmetric localization of ASH1mRNA; binds double-stranded RNA in vitro;constituent of 66S pre-ribosomal particles 0.00120.01268&radic&radic&radic&radic&radic&radic S000001457YAP5YIR018WverifiedBasic leucine zipper (bZIP) transcription factor 0.001190.01258&radic&radic&radic&radic S000005190VPS75YNL246WverifiedProtein of unknown function involved in vacuolar proteinsorting; detected in the nucleus 0.001190.01258&radic&radic&radic&radic S000004177SKG3YLR187WuncharacterizedProtein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to the cellperiphery, cytoplasm, bud, and bud neck;potential Cdc28p substrate; similar to Caf120pand Skg4p 0.001190.0125&radic&radic&radic&radic&radic S000004443LEU3YLR451WverifiedZinc-finger transcription factor that regulates genes involvedin branched chain amino acid biosynthesis andammonia assimilation; positively regulated byalpha-isopropylmalate, an intermediate inleucine biosynthesis 0.001190.0125&radic&radic&radic S000004607TAF4YMR005WverifiedTFIID subunit (48 kDa), involved in RNA polymerase IItranscription initiation; potential Cdc28psubstrate 0.001190.0125&radic S000004871YMR258CUncharacterizedProtein of unknown function with similarity to F-box proteins; physically interacts with Skp1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR258C is not an essential gene 0.001190.0125&radic&radic&radic&radic&radic S000004774MSS11YMR164CverifiedTranscription factor involved in regulation of invasive growthand starch degradation; controls the activationof MUC1 and STA2 in response to nutritionalsignals 0.001190.0125&radic&radic&radic&radic S000004718MED11YMR112CverifiedEssential subunit of the RNA polymerase II mediator complex;associates with core polymerase subunits toform the RNA polymerase II holoenzyme 0.001190.01243&radic&radic S000001462DAL81YIR023WverifiedPositive regulator of genes in multiple nitrogen degradationpathways; contains DNA binding domain but doesnot appear to bind the dodecanucleotidesequence present in the promoter region of manygenes involved in allantoin catabolism 0.001180.01236&radic&radic S000006047NAN1YPL126WverifiedU3 snoRNP protein, component of the small (ribosomal) subunit(SSU) processosome containing U3 snoRNA;required for the biogenesis of18S rRNA 0.001180.01236&radic S000005403NTG2YOL043CverifiedDNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involvedin base excision repair, localizes to thenucleus 0.001180.01236&radic&radic&radic&radic&radic S000002303YDL144CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene. 0.001180.01236&radic&radic S000001863HAC1YFL031WverifiedbZIP transcription factor (ATF/CREB1 homolog) that regulatesthe unfolded protein response, via UPREbinding, and membrane biogenesis; ERstress-induced splicing pathway utilizingIre1p, Trl1p and Ada5p facilitates efficientHac1p synthesis 0.001180.01236&radic&radic&radic&radic S000002574TAF10YDR167WverifiedSubunit (145 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification 0.001180.01236&radic&radic&radic&radic&radic S000002723IPK1YDR315CverifiedInositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear proteinrequired for synthesis of1,2,3,4,5,6-hexakisphosphate (phytate), whichis integral to cell function; has 2 motifsconserved in other fungi; ipk1 gle1 doublemutant is inviable 0.001180.01233&radic&radic S000002563RPA14YDR156WverifiedRNA polymerase I subunit A14 0.001180.01229&radic S000004466YAP1YML007WverifiedBasic leucine zipper (bZIP) transcription factor required foroxidative stress tolerance; mediatespleiotropic drug and metal resistance;localized to the nucleus in response to thepresence of oxidants 0.001180.01229&radic&radic&radic S000002450NRG1YDR043CverifiedTranscriptional repressor that recruits the Cyc8p-Tup1p complexto promoters; mediates glucose repression andnegatively regulates a variety of processesincluding filamentous growth and alkaline pHresponse 0.001180.01229&radic&radic S000001249SKN7YHR206WverifiedNuclear response regulator and transcription factor, part of abranched two-component signaling system;required for optimal induction of heat-shockgenes in response to oxidative stress; involvedin osmoregulation 0.001180.01229&radic&radic&radic&radic S000005226POP3YNL282WverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends 0.001180.01221&radic&radic&radic&radic&radic S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling 0.001180.01221&radic&radic&radic&radic&radic&radic S000002259DUN1YDL101CverifiedCell-cycle checkpoint serine-threonine kinase required for DNAdamage-induced transcription of certain targetgenes, phosphorylation of Rad55p and Sml1p, andtransient G2/M arrest after DNA damage; alsoregulates postreplicative DNA repair 0.001180.01214&radic&radic S000006059SPP1YPL138CverifiedSubunit of COMPASS (Set1C), a complex which methylates histoneH3 on lysine 4 and is required in telomerictranscriptional silencing; PHD finger domainprotein similar to human CGBP, an unmethylatedCpG binding protein 0.001180.01214&radic&radic&radic&radic&radic S000004645ARG80YMR042WverifiedTranscription factor involved in regulation ofarginine-responsive genes; acts with Arg81p andArg82p 0.001180.01214&radic&radic&radic&radic S000003003MIG1YGL035CverifiedTranscription factor involved in glucose repression; C2H2 zincfinger protein similar to mammalian Egr andWilms tumor proteins 0.001180.01214&radic&radic S000001104RPP1YHR062CverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends 0.001170.01208&radic&radic&radic&radic S000001498PUT3YKL015WverifiedTranscriptional activator of proline utilization genes,constitutively binds PUT1 and PUT2 promotersequences and undergoes a conformational changeto form the active state; has a Zn(2)-Cys(6)binuclear cluster domain 0.001170.01208&radic&radic&radic&radic S000000364CDC28YBR160WverifiedCatalytic subunit of the main cell cycle cyclin-dependentkinase (CDK); alternately associates with G1cyclins (CLNs) and G2/M cyclins (CLBs) whichdirect the CDK to specific substrates 0.001170.01208&radic S000001930PHO4YFR034CverifiedBasic helix-loop-helix (bHLH) transcription factor; bindscooperatively with Pho2p to the PHO5 promoter;function is regulated by phosphorylation atmultiple sites and by phosphate availability 0.001170.01208&radic&radic&radic&radic S000004261YLR271WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YLR271W is not an essential gene 0.001170.01208&radic&radic&radic&radic S000005783CDC31YOR257WverifiedComponent of the spindle pole body (SPB) half-bridge, requiredfor SPB duplication in mitosis and meiosis II;homolog of mammalian centrin; interacts withKar1p 0.001170.01208&radic&radic&radic&radic S000006308FHL1YPR104CverifiedPutative transcriptional regulator with similarity toDNA-binding domain of Drosophila forkhead;required for rRNA processing 0.001170.01208&radic&radic S000004826CEF1YMR213WverifiedEssential splicing factor; associated with Prp19p and thespliceosome, contains an N-terminal c-Myb DNAbinding motif necessary for cell viability butnot for Prp19p association, evolutionarilyconserved and homologous to S. pombe Cdc5p 0.001170.012&radic&radic&radic&radic S000005654ADE2YOR128CverifiedPhosphoribosylaminoimidazole carboxylase, catalyzes a step inthe 'de novo' purine nucleotide biosyntheticpathway; red pigment accumulates in mutantcells deprived of adenine 0.001170.012&radic&radic&radic S000001597APN1YKL114CverifiedMajor apurinic/apyrimidinic endonuclease, 3'-repair diesteraseinvolved in repair of DNA damage by oxidationand alkylating agents; also functions as a3'-5' exonuclease to repair7,8-dihydro-8-oxodeoxyguanosine 0.001170.012&radic&radic&radic&radic&radic&radic S000003372CBF2YGR140WverifiedEssential kinetochore protein, component of the CBF3multisubunit complex that binds to the CDEIIIregion of the centromere; Cbf2p also binds tothe CDEII region possibly forming a differentmultimeric complex, ubiquitinated in vivo 0.001170.012&radic&radic&radic&radic&radic S000001669MTR2YKL186CverifiedmRNA transport regulator, essential nuclear protein; Mex67p andMtr2p form a mRNA export complex which binds toRNA 0.001170.012&radic&radic S000004876SAP30YMR263WverifiedSubunit of a histone deacetylase complex, along with Rpd3p andSin3p, that is involved in silencing attelomeres, rDNA, and silent mating-type loci;involved in telomere maintenance 0.001170.012&radic&radic&radic&radic S000005218YNL274CUncharacterizedPutative hydroxyisocaproate dehydrogenase 0.001170.01188&radic&radic S000002545HPR1YDR138WverifiedSubunit of THO/TREX complexes that couple transcriptionelongation with mitotic recombination and withmRNA metabolism and export, subunit of an RNAPol II complex; regulates lifespan; involved intelomere maintenance; similar to Top1p 0.001170.01188&radic&radic&radic S000001714MRPL13YKR006CverifiedMitochondrial ribosomal protein of the large subunit, notessential for mitochondrial translation 0.001170.01188&radic&radic S000003412RNR4YGR180CverifiedRibonucleotide-diphosphate reductase (RNR), small subunit; theRNR complex catalyzes the rate-limiting step indNTP synthesis and is regulated by DNAreplication and DNA damage checkpoint pathwaysvia localization of the small subunits 0.001170.01188&radic&radic&radic&radic&radic S000001934IRC5YFR038WuncharacterizedPutative ATPase containing the DEAD/H helicase-related sequencemotif; null mutant displays increased levels ofspontaneous Rad52 foci 0.001160.0118&radic&radic&radic&radic S000004581DAT1YML113WverifiedDNA binding protein that recognizes oligo(dA).oligo(dT) tracts;Arg side chain in its N-terminal pentadGly-Arg-Lys-Pro-Gly repeat is required forDNA-binding; not essential for viability 0.001170.0118&radic&radic S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.001170.0118&radic&radic&radic&radic S000005298SMM1YNR015WverifiedDihydrouridine synthase, member of a family of dihydrouridinesynthases including Dus1p, Smm1p, Dus3p, andDus4p; modifies uridine residues at position 20of cytoplasmic tRNAs 0.001170.0118&radic&radic S000004872YMR259CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR259C is not an essential gene 0.001170.0118&radic&radic&radic&radic S000002283HNT1YDL125CverifiedAdenosine 5'-monophosphoramidase; interacts physically andgenetically with Kin28p, a CDK and TFIIKsubunit, and genetically with CAK1; member ofthe histidine triad (HIT) superfamily ofnucleotide-binding proteins and similar to Hint 0.001170.0118&radic&radic S000004157RPS31YLR167WverifiedFusion protein that is cleaved to yield a ribosomal protein ofthe small (40S) subunit and ubiquitin;ubiquitin may facilitate assembly of theribosomal protein into ribosomes; interactsgenetically with translation factor eIF2B 0.001160.01179&radic&radic&radic&radic&radic S000005428RTG1YOL067CverifiedTranscription factor (bHLH) involved in interorganellecommunication between mitochondria,peroxisomes, and nucleus 0.001160.01179&radic&radic&radic&radic S000002794MUS81YDR386WverifiedHelix-hairpin-helix protein, involved in DNA repair andreplication fork stability; functions as anendonuclease in complex with Mms4p; interactswith Rad54p 0.001160.01179&radic&radic&radic&radic&radic S000004647IOC4YMR044WverifiedMember of a complex (Isw1b) with Isw1p and Ioc2p that exhibitsnucleosome-stimulated ATPase activity and actswithin coding regions to coordinatetranscription elongation with termination andprocessing, contains a PWWP motif 0.001160.01173&radic&radic&radic&radic S000004616BUD22YMR014WverifiedProtein involved in bud-site selection; diploid mutants displaya random budding pattern instead of thewild-type bipolar pattern 0.001160.01173&radic&radic&radic&radic&radic S000005682NFI1YOR156CverifiedSUMO ligase, catalyzes the covalent attachment of SUMO (Smt3p)to proteins; involved in maintenance of propertelomere length 0.001160.01173&radic&radic&radic S000006077PRM4YPL156CverifiedPheromone-regulated protein, predicted to have 1 transmembranesegment; transcriptionally regulated by Ste12pduring mating and by Cat8p during the diauxicshift 0.001160.01173&radic&radic&radic S000001119NMD2YHR077CverifiedProtein involved in the nonsense-mediated mRNA decay (NMD)pathway; interacts with Nam7p and Upf3p;involved in telomere maintenance 0.001160.01171&radic&radic S000004092APC9YLR102CverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 0.001160.01161&radic&radic&radic&radic&radic S000005667ARP8YOR141CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes 0.001160.01161&radic&radic&radic&radic&radic S000004449NBP1YLR457CverifiedSpindle pole body (SPB) component, required for the insertionof the duplication plaque into the nuclearmembrane during SPB duplication; essential forbipolar spindle formation; component of theMps2p-Bbp1p complex 0.001160.01161&radic S000003190EDC1YGL222CverifiedRNA-binding protein, activates mRNA decapping directly bybinding to the mRNA substrate and enhancing theactivity of the decapping proteins Dcp1p andDcp2p 0.001160.01161&radic&radic&radic S000003820PTK2YJR059WverifiedPutative serine/threonine protein kinase involved in regulationof ion transport across plasma membrane;enhances spermine uptake 0.001160.01161 S000000076YAR028WUncharacterizedPutative integral membrane protein, member of DUP240 gene family 0.001160.01159&radic&radic&radic&radic S000000119MCM2YBL023CverifiedProtein involved in DNA replication; component of the Mcm2-7hexameric complex that binds chromatin as apart of the pre-replicative complex 0.001160.01159&radic&radic&radic&radic S000001906UBP6YFR010WverifiedUbiquitin-specific protease situated in the base subcomplex ofthe 26S proteasome, releases free ubiquitinfrom branched polyubiquitin chains; deletioncauses hypersensitivity to cycloheximide andother toxic compounds 0.001160.01159&radic&radic&radic&radic&radic S000002488PDC2YDR081CverifiedTranscription factor required for the synthesis of theglycolytic enzyme pyruvate decarboxylase,required for high level expression of both theTHI and the PDC genes 0.001160.01153&radic&radic&radic&radic S000002290CDC53YDL132WverifiedCullin, structural protein of SCF complexes (which also containSkp1p, Cdc34p, and an F-box protein) involvedin ubiquitination; SCF promotes the G1-Stransition by targeting G1 cyclins and theCln-CDK inhibitor Sic1p for degradation 0.001150.01153&radic&radic S000002657YDR249CUncharacterizedHypothetical protein 0.001150.01153&radic&radic&radic&radic&radic S000004674MOT3YMR070WverifiedNuclear transcription factor with two Cys2-His2 zinc fingers;involved in repression of a subset of hypoxicgenes by Rox1p, repression of several DAN/TIRgenes during aerobic growth, and repression ofergosterol biosynthetic genes 0.001160.01153&radic&radic S000001625MRP8YKL142WverifiedPutative mitochondrial ribosomal protein, has similarity to E.coli ribosomal protein S2 0.001160.01153&radic&radic&radic S000005578YOR052CUncharacterizedHypothetical protein 0.001150.01148&radic&radic&radic&radic&radic S000004842RRP5YMR229CverifiedProtein required for the synthesis of both 18S and 5.8S rRNA;C-terminal region is crucial for the formationof 18S rRNA and N-terminal region is requiredfor the 5.8S rRNA; component of small ribosomalsubunit (SSU) processosome 0.001150.01143&radic&radic&radic&radic&radic S000001749YKR041WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 0.001150.01143&radic&radic S000005372HTZ1YOL012CverifiedHistone variant H2AZ, exchanged for histone H2A in nucleosomesby the SWR1 complex; involved intranscriptional regulation through preventionof the spread of silent heterochromatin 0.001150.01143&radic&radic&radic S000005396YOL036WUncharacterizedProtein of unknown function; potential Cdc28p substrate 0.001150.01143&radic&radic&radic S000001942CNN1YFR046CverifiedKinetochore protein of unknown function; associated with theessential kinetochore proteins Nnf1p andSpc24p; phosphorylated by both Clb5-Cdk1 and,to a lesser extent, Clb2-Cdk1. 0.001150.01143&radic&radic&radic&radic&radic S000004367STP3YLR375WuncharacterizedZinc-finger protein of unknown function, possibly involved inpre-tRNA splicing and in uptake ofbranched-chain amino acids 0.001150.01143&radic&radic&radic&radic&radic S000003206HAP2YGL237CverifiedSubunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5pCCAAT-binding complex, a transcriptionalactivator and global regulator of respiratorygene expression; contains sequences sufficientfor both complex assembly and DNA binding 0.001150.01141&radic&radic S000005125YNL181WUncharacterizedProtein required for cell viability 0.001150.01137&radic S000005806FSH3YOR280CverifiedSerine hydrolase; sequence is similar to Fsh1p and Fsh2p 0.001150.01137&radic&radic S000004980YNL035CUncharacterizedPutative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene 0.001150.01137&radic&radic S000005162MGS1YNL218WverifiedProtein with DNA-dependent ATPase and ssDNA annealingactivities involved in maintenance of genome;interacts functionally with DNA polymerasedelta; homolog of human Werner helicaseinteracting protein (WHIP) 0.001150.01137&radic&radic&radic S000000124YBL028CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis 0.001150.01137&radic&radic S000005056DBP2YNL112WverifiedEssential ATP-dependent RNA helicase of the DEAD-box proteinfamily, involved in nonsense-mediated mRNAdecay and rRNA processing 0.001150.01135&radic&radic S000001582UTP11YKL099CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.001150.01135&radic&radic S000006366ORC4YPR162CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing 0.001150.01135&radic&radic S000002568YDR161WUncharacterizedinteracts with PP2C 0.001150.01132&radic&radic&radic S000005163ALG9YNL219CverifiedMannosyltransferase, involved in N-linked glycosylation;catalyzes the transfer of mannose fromDol-P-Man to lipid-linked oligosaccharides;mutation of the human ortholog causes type 1congenital disorders of glycosylation 0.001150.01132&radic&radic&radic&radic&radic S000003804POL32YJR043CverifiedThird subunit of DNA polymerase delta, involved in chromosomalDNA replication; required for error-prone DNAsynthesis in the presence of DNA damage andprocessivity; interacts with Hys2p, PCNA(Pol30p), and Pol1p 0.001150.01132&radic&radic S000002713HNT2YDR305CverifiedDinucleoside triphosphate hydrolase; has similarity to thetumor suppressor FHIT and belongs to thehistidine triad (HIT) superfamily ofnucleotide-binding proteins 0.001150.01132&radic&radic&radic&radic S000005253STB1YNL309WverifiedProtein with a role in regulation of MBF-specific transcriptionat Start, phosphorylated by Cln-Cdc28p kinasesin vitro; unphosphorylated form binds Swi6p andbinding is required for Stb1p function;expression is cell-cycle regulated 0.001140.0112&radic&radic&radic&radic S000005609WHI5YOR083WverifiedRepressor of G1 transcription that binds to SCB binding factor(SBF) at SCB target promoters in early G1;phosphorylation of Whi5p by the CDK,Cln3p/Cdc28p relieves repression and promoterbinding by Whi5; periodically expressed in G1 0.001140.0112&radic&radic&radic S000003306SMD1YGR074WverifiedCore Sm protein Sm D1; part of heteroheptameric complex (withSmb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D1 0.001140.0112&radic&radic&radic S000004565ARG81YML099CverifiedZinc-finger transcription factor of the Zn(2)-Cys(6) binuclearcluster domain type, involved in the regulationof arginine-responsive genes; acts with Arg80pand Arg82p 0.001140.0112&radic&radic S000001139YHR097CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus 0.001140.0112&radic&radic&radic&radic&radic&radic S000001516YKL033WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YKL033W is an essential gene 0.001140.0112&radic&radic&radic S000002256SNU23YDL098CverifiedComponent of U4/U6.U5 snRNP involved in mRNA splicing viaspliceosome 0.001140.01118&radic&radic S000001017SNF6YHL025WverifiedSubunit of the SWI/SNF chromatin remodeling complex involved intranscriptional regulation; functionsinterdependently in transcriptional activationwith Snf2p and Snf5p 0.001140.01118&radic&radic S000000752SNU13YEL026WverifiedRNA binding protein, part of U3 snoRNP involved in rRNAprocessing, part of U4/U6-U5 tri-snRNP involvedin mRNA splicing, similar to human 15.5Kprotein 0.001140.01118&radic&radic&radic&radic S000005051YAF9YNL107WverifiedSubunit of both the NuA4 histone H4 acetyltransferase complexand the SWR1 complex, may function toantagonize silencing near telomeres; interactsdirectly with Swc4p, has homology to humanleukemogenic protein AF9, contains a YEATSdomain 0.001140.01118&radic&radic S000002579SUP35YDR172WverifiedTranslation termination factor eRF3; altered proteinconformation creates the [PSI(+)] prion, adominant cytoplasmically inherited proteinaggregate that alters translational fidelityand creates a nonsense suppressor phenotype 0.001140.01106&radic&radic&radic&radic S000002157NHP6BYBR089C-AverifiedHigh-mobility group non-histone chromatin protein, functionallyredundant with Nhp6Ap; homologous to mammalianhigh mobility group proteins 1 and 2; acts torecruit transcription factor Rcs1p to certainpromoters 0.001140.01106&radic&radic S000004289YHC1YLR298CverifiedComponent of the U1 snRNP complex required for pre-mRNAsplicing; putative ortholog of human U1Cprotein, which is involved in formation of acomplex between U1 snRNP and the pre-mRNA 5'splice site 0.001140.01106&radic&radic&radic S000001526PHD1YKL043WverifiedTranscriptional activator that enhances pseudohyphal growth;regulates expression of FLO11, an adhesinrequired for pseudohyphal filament formation;similar to StuA, an A. nidulans developmentalregulator; potential Cdc28p substrate 0.001140.01106&radic&radic&radic S000000189ROX3YBL093CverifiedRNA polymerase II holoenzyme component 0.001140.01106&radic&radic&radic&radic S000004064BUD20YLR074CverifiedProtein involved in bud-site selection; diploid mutants displaya random budding pattern instead of thewild-type bipolar pattern 0.001140.01106&radic&radic&radic S000004232ARV1YLR242CverifiedProtein required for normal intracellular sterol distributionand for sphingolipid metabolism; similar toNup120p and C. elegans R05H5.5 protein 0.001140.01106&radic&radic&radic&radic S000001924CDC14YFR028CverifiedProtein phosphatase required for mitotic exit; located in thenucleolus until liberated by the FEAR andMitotic Exit Network in anaphase, enabling itto act on key substrates to effect a decreasein CDK/B-cyclin activity and mitotic exit 0.001140.01106&radic S000005047MET4YNL103WverifiedLecine-zipper transcriptional activator, responsible for theregulation of the sulfur amino acid pathway,requires different combinations of theauxiliary factors Cbf1p, Met28p, Met31p andMet32p 0.001140.01097&radic&radic S000005316ABZ1YNR033WverifiedPara-aminobenzoate (PABA) synthase, has similarity toEscherichia coli PABA synthase components PabAand PabB 0.001140.01097&radic S000000403KTR4YBR199WverifiedPutative mannosyltransferase involved in protein glycosylation;member of the KRE2/MNT1 mannosyltransferasefamily 0.001140.01097&radic&radic&radic&radic S000002725HIM1YDR317WverifiedProtein of unknown function involved in DNA repair 0.001140.01097&radic&radic&radic&radic S000002618YDR210WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery 0.001140.01097&radic&radic&radic&radic S000006314RPC40YPR110CverifiedRNA polymerase subunit, common to RNA polymerase I and III 0.001130.01089&radic&radic&radic&radic&radic S000006323CLB2YPR119WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the transition from G2 to Mphase; accumulates during G2 and M, thentargeted via a destruction box motif forubiquitin-mediated degradation by theproteasome 0.001130.01089&radic&radic&radic&radic S000003403MSM1YGR171CverifiedMitochondrial methionyl-tRNA synthetase (MetRS), functions as amonomer in mitochondrial protein synthesis;functions similarly to cytoplasmic MetRSalthough the cytoplasmic form contains azinc-binding domain not found in Msm1p 0.001130.01089&radic&radic&radic S000000047YAL049CUncharacterizedHypothetical protein 0.001130.01089&radic&radic&radic&radic&radic S000004814RAD14YMR201CverifiedProtein that recognizes and binds damaged DNA during nucleotideexcision repair; subunit of Nucleotide ExcisionRepair Factor 1 (NEF1); contains zinc fingermotif; homolog of human XPA protein 0.001130.01089&radic&radic&radic&radic S000002635SIR4YDR227WverifiedSilent information regulator that, together with SIR2 and SIR3,is involved in assembly of silent chromatindomains at telomeres and the silent mating-typeloci; potentially phosphorylated by Cdc28p;some alleles of SIR4 prolong lifespan 0.001130.01089&radic&radic&radic S000002175CDC7YDL017WverifiedDDK (Dbf4-dependent kinase) catalytic subunit required forfiring origins and replication fork progressionin mitosis through phosphorylation of Mcm2-7pcomplexes and Cdc45p; kinase activitycorrelates with cyclical DBF4 expression 0.001130.01087&radic&radic S000005869YOR342CUncharacterizedHypothetical protein 0.001130.01087&radic&radic&radic S000003341CLB6YGR109CverifiedB-type cyclin involved in DNA replication during S phase;activates Cdc28p to promote initiation of DNAsynthesis; functions in formation of mitoticspindles along with Clb3p and Clb4p; mostabundant during late G1 0.001130.01087&radic&radic&radic&radic S000001768UTP30YKR060WuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.001130.01087&radic&radic&radic S000001721PRY2YKR013WverifiedProtein of unknown function, has similarity to Pry1p and Pry3pand to the plant PR-1 class of pathogen relatedproteins 0.001130.01083&radic&radic S000004901HSH155YMR288WverifiedU2-snRNP associated splicing factor that forms extensiveassociations with the branch site-3' splicesite-3' exon region upon prespliceosomeformation; similarity to the mammalian U2snRNP-associated splicing factor SAP155 0.001130.01083&radic&radic&radic&radic&radic&radic S000003368LSB1YGR136WverifiedProtein containing an N-terminal SH3 domain; binds Las17p,which is a homolog of human Wiskott-AldrichSyndrome protein involved in actin patchassembly and actin polymerization 0.001130.01083&radic&radic&radic&radic&radic S000004173TOS4YLR183CverifiedTranscription factor that binds to a number of promoterregions, particularly promoters of some genesinvolved in pheromone response and cell cycle;potential Cdc28p substrate; expression isinduced in G1 by bound SBF 0.001130.0108&radic&radic&radic&radic S000005565CKB2YOR039WverifiedBeta' regulatory subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKA2 and CKB1, the many substratesinclude transcription factors and all RNApolymerases 0.001130.0108&radic&radic S000005464NDJ1YOL104CverifiedMeiosis-specific telomere protein, required for bouquetformation, effective homolog pairing, orderedcross-over distribution (interference), sisterchromatid cohesion at meiotic telomeres, andsegregation of small chromosomes 0.001130.0108&radic S000003026RAD6YGL058WverifiedUbiquitin-conjugating enzyme (E2), involved in postreplicationrepair (with Rad18p), sporulation, telomeresilencing, and ubiquitin-mediated N-end ruleprotein degradation (with Ubr1p) 0.001120.01062&radic&radic&radic&radic&radic S000002263NSE4YDL105WverifiedNuclear protein that plays a role in the function of theSmc5p-Rhc18p complex 0.001130.01062&radic&radic S000002993PGD1YGL025CverifiedSubunit of the Mediator global transcriptional cofactorcomplex, which is part of the RNA polymerase IIholoenzyme and plays an essential role in basaland activated transcription; direct target ofthe Cyc8p-Tup1p transcriptional corepressor 0.001130.01062&radic&radic&radic&radic&radic S000005160RAP1YNL216WverifiedDNA-binding protein involved in either activation or repressionof transcription, depending on binding sitecontext; also binds telomere sequences andplays a role in telomeric position effect(silencing) and telomere structure 0.001130.01062&radic&radic&radic&radic&radic&radic S000000820SPC25YER018CverifiedComponent of the evolutionarily conservedkinetochore-associated Ndc80 complex(Ndc80p-Nuf2p-Spc24p-Spc25p); involved inchromosome segregation, spindle checkpointactivity and kinetochore clustering 0.001130.01062&radic&radic S000003030PYC1YGL062WverifiedPyruvate carboxylase isoform, cytoplasmic enzyme that convertspyruvate to oxaloacetate; highly similar toisoform Pyc2p but differentially regulated;mutations in the human homolog are associatedwith lactic acidosis 0.001130.01062&radic&radic&radic&radic S000006341RRP9YPR137WverifiedProtein involved in pre-rRNA processing, associated with U3snRNP; component of small ribosomal subunit(SSU) processosome; ortholog of the humanU3-55k protein 0.001120.01062&radic&radic&radic&radic&radic S000001191IMP3YHR148WverifiedComponent of the SSU processome, which is required for pre-18SrRNA processing, essential protein thatinteracts with Mpp10p and mediates interactionsof Imp4p and Mpp10p with U3 snoRNA 0.001130.01062&radic&radic&radic&radic S000000398SOY1YBR194WuncharacterizedProtein proposed to be associated with the nuclear pore complex 0.001130.01062&radic&radic&radic&radic&radic&radic S000001785YKR077WUncharacterizedPutative transcriptional activator, identified by high-throughput two-hybrid experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YKR077W is not an essential gene 0.001120.01062&radic&radic&radic S000001515IXR1YKL032CverifiedProtein that binds DNA containing intrastrand cross-linksformed by cisplatin, contains two HMG (highmobility group box) domains, which confer theability to bend cisplatin-modified DNA;mediates aerobic transcriptional repression ofCOX5b 0.001120.01062&radic&radic&radic&radic S000002847LRS4YDR439WverifiedProtein involved in rDNA silencing; positively chargedcoiled-coil protein with limited similarity tomyosin 0.001120.01062&radic S000000808NUG1YER006WverifiedGTPase that associates with nuclear 60S pre-ribosomes, requiredfor export of 60S ribosomal subunits from thenucleus 0.001130.01062&radic&radic&radic&radic S000004260DCS1YLR270WverifiedNon-essential hydrolase involved in mRNA decapping, mayfunction in a feedback mechanism to regulatedeadenylation, contains pyrophosphataseactivity and a HIT (histidine triad) motif;interacts with neutral trehalase Nth1p 0.001120.01062&radic&radic&radic&radic S000001019RIM101YHL027WverifiedTranscriptional repressor involved in response to pH and incell wall construction; required for alkalinepH-stimulated haploid invasive growth andsporulation; activated by proteolyticprocessing; similar to A. nidulans PacC 0.001130.01062&radic&radic&radic S000005743RFC1YOR217WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon 0.001120.01062&radic&radic&radic&radic S000000865THO1YER063WverifiedProtein of unknown function; overproduction suppresses thetranscriptional defect caused by an hpr1mutation 0.001120.01062&radic&radic S000003958GRC3YLL035WverifiedProtein of unknown function, required for cell growth andpossibly involved in rRNA processing; mRNA iscell cycle regulated 0.001120.01059&radic&radic S000004079ALT1YLR089CuncharacterizedPutative alanine transaminase (glutamic pyruvic transaminase);the authentic, non-tagged protein is detectedin highly purified mitochondria inhigh-throughput studies 0.001120.01059&radic&radic&radic&radic S000002562CPR1YDR155CverifiedCytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin),catalyzes the cis-trans isomerization ofpeptide bonds N-terminal to proline residues;binds the drug cyclosporin A 0.001120.01055&radic&radic&radic&radic S000002720SSF2YDR312WverifiedProtein required for ribosomal large subunit maturation,functionally redundant with Ssf1p; member ofthe Brix family 0.001120.01055&radic&radic&radic&radic&radic S000001533YKL050CUncharacterizedPutative protein of unknown function 0.001120.01055&radic&radic&radic S000002615UME6YDR207CverifiedKey transcriptional regulator of early meiotic genes, bindsURS1 upstream regulatory sequence, couplesmetabolic responses to nutritional cues withinitiation and progression of meiosis, formscomplex with Ime1p, and also with Sin3p-Rpd3p 0.001120.01055&radic&radic&radic&radic&radic S000000402TAF5YBR198CverifiedSubunit (90 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification 0.001120.01055&radic&radic&radic&radic&radic&radic S000001770TFA2YKR062WverifiedTFIIE small subunit, involved in RNA polymerase IItranscription initiation 0.001120.01055&radic&radic&radic&radic&radic&radic S000005020MKS1YNL076WverifiedPleiotropic regulatory factor involved in Ras-CAMP and lysinebiosynthetic pathways and nitrogen regulation;involved in retrograde (RTG)mitochondria-to-nucleus signaling 0.001120.01055&radic S000006066KES1YPL145CverifiedMember of the oxysterol binding protein family, which includesseven yeast homologs; involved in negativeregulation of Sec14p-dependent Golgi complexsecretory functions, peripheral membraneprotein that localizes to the Golgi complex 0.001120.01051&radic&radic&radic&radic S000002797SAC7YDR389WverifiedGTPase activating protein (GAP) for Rho1p, involved insignaling to the actin cytoskeleton, nullmutations suppress tor2 mutations andtemperature sensitive mutations in actin;potential Cdc28p substrate 0.001120.01051&radic&radic&radic&radic&radic S000005842SFG1YOR315WverifiedNuclear protein, putative transcription factor required forgrowth of superficial pseudohyphae (which donot invade the agar substrate) but not forinvasive pseudohyphal growth; may act togetherwith Phd1p; potential Cdc28p substrate 0.001120.01051&radic&radic&radic S000004788ECM5YMR176WverifiedNon-essential protein of unknown function, containsATP/GTP-binding site motif A; null mutantexhibits cellular volume up to four timesgreater than wild-type, also large droopingbuds with elongated necks 0.001120.01051&radic&radic&radic&radic&radic S000005429HST1YOL068CverifiedNAD(+)-dependent histone deacetylase; essential subunit of theSum1p/Rfm1p/Hst1p complex required forORC-dependent silencing and mitotic repression;non-essential subunit of the Set3C deacetylasecomplex; involved in telomere maintenance 0.001120.01044&radic&radic&radic&radic S000000703RDS1YCR106WverifiedZinc cluster protein involved in conferring resistance tocycloheximide 0.001120.01044&radic&radic S000000103SLA1YBL007CverifiedCytoskeletal protein binding protein required for assembly ofthe cortical actin cytoskeleton; contains 3 SH3domains; interacts with proteins regulatingactin dynamics and with proteins required forendocytosis 0.001120.01044&radic&radic&radic S000004099AHP1YLR109WverifiedThiol-specific peroxiredoxin, reduces hydroperoxides to protectagainst oxidative damage; function in vivorequires covalent conjugation to Urm1p 0.001120.01044&radic&radic&radic&radic&radic S000003276RME1YGR044CverifiedZinc finger protein involved in control of meiosis; preventsmeiosis by repressing IME1 expression andpromotes mitosis by activating CLN2 expression;directly repressed by a1-a2 regulator; mediatescell type control of sporulation 0.001120.01044&radic&radic&radic S000002575CDC37YDR168WverifiedEssential Hsp90p co-chaperone; necessary for passage throughthe START phase of the cell cycle 0.001120.01044&radic&radic&radic&radic S000001800SRP40YKR092CverifiedNucleolar, serine-rich protein with a role in preribosomeassembly or transport; may function as achaperone of small nucleolar ribonucleoproteinparticles (snoRNPs); immunologically andstructurally to rat Nopp140 0.001120.01044&radic S000003175SPT16YGL207WverifiedSubunit of the heterodimeric FACT complex (Spt16p-Pob3p),facilitates RNA Polymerase II transcriptionelongation through nucleosomes by destabilizingand then reassembling nucleosome structure 0.001120.01044&radic&radic&radic&radic&radic S000000823RPN3YER021WverifiedEssential, non-ATPase regulatory subunit of the 26S proteasomelid, similar to the p58 subunit of the human26S proteasome; temperature-sensitive allelescause metaphase arrest, suggesting a role forthe proteasome in cell cycle control 0.001120.01044&radic&radic&radic S000000112FUS3YBL016WverifiedMitogen-activated protein kinase involved in mating pheromoneresponse; activated by phosphorylation bySte7p; provides specificity during the matingvs. filamentous growth response byphosphorylating transcriptional and cytoplasmictargets 0.001120.01041&radic&radic&radic S000003390MTR3YGR158Cverified3'5' exoribonuclease, exosome subunit; nucleolar proteininvolved in export of mRNA and ribosomalsubunits; homologous to the E. coli exonucleaseRNase PH 0.001120.01041&radic&radic&radic&radic&radic S000004121ACE2YLR131CverifiedTranscription factor that activates expression of earlyG1-specific genes, localizes to daughter cellnuclei after cytokinesis and delays G1progression in daughters, localization isregulated by phosphorylation; potential Cdc28psubstrate 0.001120.01041&radic&radic&radic&radic S000001656SNU114YKL173WverifiedGTPase component of U5 snRNP involved in mRNA splicing viaspliceosome; binds directly to U5 snRNA;proposed to be involved in conformationalchanges of the spliceosome; similarity toribosomal translocation factor EF-2 0.001120.01041&radic&radic&radic&radic S000001082BCD1YHR040WverifiedEssential protein required for the accumulation of box C/DsnoRNA 0.001120.01041&radic&radic&radic&radic&radic S000001608RRN3YKL125WverifiedProtein required for transcription of rDNA by RNA polymerase I;transcription factor independent of DNAtemplate; involved in recruitment of RNApolymerase I to rDNA 0.001120.01041&radic&radic&radic&radic&radic S000006060UME1YPL139CverifiedNegative regulator of meiosis, required for repression of asubset of meiotic genes during vegetativegrowth, binding of histone deacetylase Rpd3prequired for activity, contains a NEE box and aWD repeat motif; homologous with Wtm1p, Wtm2p 0.001120.01036&radic&radic&radic&radic S000005805RFM1YOR279CverifiedDNA-binding protein required for vegetative repression ofmiddle sporulation genes; specificity factorthat directs the Hst1p histone deacetylase tosome of the promoters regulated by Sum1p;involved in telomere maintenance 0.001120.01036&radic&radic S000003739PRP21YJL203WverifiedSubunit of the SF3a splicing factor complex, required forspliceosome assembly 0.001120.01036&radic&radic&radic&radic&radic S000005835SNU66YOR308CverifiedComponent of the U4/U6.U5 snRNP complex involved in pre-mRNAsplicing via spliceosome; has homology to humanSART-1 and to an S. pombe protein; snu66 nullmutation confers cold-sensitivity but is notlethal at normal growth temperatures 0.001120.01036&radic&radic&radic&radic S000004802SGS1YMR190CverifiedNucleolar DNA helicase of the RecQ family involved inmaintenance of genome integrity, regulateschromosome synapsis and meiotic crossing over;has similarity to human BLM and WRN helicasesimplicated in Bloom and Werner syndromes 0.001110.01031&radic&radic&radic S000001212DBP8YHR169WverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in biogenesis of the 40S ribosomalsubunit 0.001110.01031&radic&radic S000001935YFR039CUncharacterizedPutative protein of unknown function; YFR039C is not an essential gene 0.001110.01031&radic S000002737PEX3YDR329CverifiedPeroxisomal membrane protein (PMP) required to recruit Pex19pchaperone to peroxisomes; plays selective,essential, direct role in PMP import as adocking factor for Pex19p 0.001110.01031&radic&radic&radic S000005577YOR051CUncharacterizedNuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts 0.001110.01027&radic&radic&radic S000004223EST1YLR233CverifiedTLC1 RNA-associated factor involved in telomere lengthregulation as the recruitment subunit of thetelomerase holoenzyme, has a possible role inactivating Est2p-TLC1-RNA bound to the telomere 0.001110.01027&radic S000002552TAF12YDR145WverifiedSubunit (61/68 kDa) of TFIID and SAGA complexes, involved inRNA polymerase II transcription initiation andin chromatin modification, similar to histoneH2A 0.001110.01027&radic&radic&radic&radic&radic S000004697NPL6YMR091CverifiedComponent of the RSC chromatin remodeling complex; interactswith Rsc3p, Rsc30p, Ldb7p, and Htl1p to form amodule important for a broad range of RSCfunctions; involved in nuclear protein importand maintenance of proper telomere length 0.001110.01027&radic&radic S000005092ALF1YNL148CverifiedAlpha-tubulin folding protein, similar to mammalian cofactor B;Alf1p-GFP localizes to cytoplasmicmicrotubules; required for the folding ofalpha-tubulin and may play an additional rolein microtubule maintenance 0.001110.01027&radic&radic&radic&radic S000005685SME1YOR159CverifiedCore Sm protein Sm E; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm E 0.001110.01027&radic&radic&radic&radic&radic S000000521DCC1YCL016CverifiedSubunit of a complex with Ctf8p and Ctf18p that shares somecomponents with Replication Factor C, requiredfor sister chromatid cohesion and telomerelength maintenance 0.001110.01023&radic&radic&radic&radic S000003815YJR054WUncharacterizedVacuolar protein of unknown function; potential Cdc28p substrate 0.001110.01023&radic S000004264CDC46YLR274WverifiedComponent of the hexameric MCM complex, which is important forpriming origins of DNA replication in G1 andbecomes an active ATP-dependent helicase thatpromotes DNA melting and elongation whenactivated by Cdc7p-Dbf4p in S-phase 0.001110.01023&radic&radic&radic S000002307NOP14YDL148CverifiedNucleolar protein, forms a complex with Noc4p that mediatesmaturation and nuclear export of 40S ribosomalsubunits; also present in the small subunitprocessome complex, which is required forprocessing of pre-18S rRNA 0.001110.01022&radic S000005542ERP4YOR016CverifiedProtein with similarity to Emp24p and Erv25p, member of the p24family involved in ER to Golgi transport 0.001110.01022&radic&radic&radic&radic S000003849BIR1YJR089WverifiedEssential chromosomal passenger protein involved incoordinating cell cycle events for properchromosome segregation; C-terminal region bindsSli15p, and the middle region, uponphosphorylation, localizes Cbf2p to the spindleat anaphase 0.001110.0102&radic&radic S000005138YNL194CVerifiedIntegral membrane protein localized to eisosomes, large immobile protein structures at the cell cortex associated with endocytosis; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45 0.001110.0102&radic&radic&radic S000004480YML018CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; YML018C is not an essential gene 0.001110.00996&radic&radic&radic&radic&radic S000003288RSC1YGR056WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; containstwo essential bromodomains, a bromo-adjacenthomology (BAH) domain, and an AT hook 0.001110.00996&radic&radic&radic S000002606RKM2YDR198CverifiedRibosomal protein lysine methyltransferase, responsible forepsilon-trimethylation of the lysine residue atposition 10 of Rpl12Ap and Rpl12Bp 0.00110.00996&radic&radic&radic&radic S000003212TAD1YGL243WverifiedtRNA-specific adenosine deaminase, deaminates adenosine-37 toinosine in tRNA-Ala 0.00110.00996&radic&radic&radic&radic S000005949ERG10YPL028WverifiedAcetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase),cytosolic enzyme that transfers an acetyl groupfrom one acetyl-CoA molecule to another,forming acetoacetyl-CoA; involved in the firststep in mevalonate biosynthesis 0.001110.00996&radic&radic&radic&radic S000003361SYF2YGR129WverifiedComponent of the spliceosome complex involved in pre-mRNAsplicing; involved in regulation of cell cycleprogression 0.001110.00996&radic&radic&radic&radic S000002781FRQ1YDR373WverifiedN-myristoylated calcium-binding protein that may have a role inintracellular signaling through its regulationof the phosphatidylinositol 4-kinase Pik1p;member of the recoverin/frequenin branch of theEF-hand superfamily 0.00110.00996&radic&radic&radic&radic S000002743MSN5YDR335WverifiedKaryopherin involved in nuclear import and export; shown to beresponsible for nuclear import of replicationprotein A and for export of several proteinsincluding Swi6p, Far1p, and Pho4p; cargodissociation involves binding to RanGTP 0.00110.00996&radic&radic&radic&radic S000002570CWC15YDR163WverifiedNon-essential protein involved in pre-mRNA splicing, componentof a complex containing Cef1p; has similarityto S. pombe Cwf15p 0.001110.00996&radic&radic&radic&radic S000001764TRM2YKR056WverifiedtRNA methyltransferase, 5-methylates the uridine residue atposition 54 of tRNAs and may also have a rolein tRNA stabilization or maturation; previouslythought to be an endo-exonuclease 0.001110.00996&radic S000000270NRG2YBR066CverifiedTranscriptional repressor that mediates glucose repression andnegatively regulates filamentous growth; hassimilarity to Nrg1p 0.00110.00996&radic&radic S000004478PPZ1YML016CverifiedSerine/threonine protein phosphatase Z, isoform of Ppz2p;involved in regulation of potassium transport,which affects osmotic stability, cell cycleprogression, and halotolerance 0.001110.00996&radic&radic&radic S000002802RPT3YDR394WverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; substrate ofN-acetyltransferase B 0.00110.00996&radic&radic&radic&radic&radic S000004664SAM37YMR060CverifiedComponent of the mitochondrial outer membrane sorting andassembly machinery (SAM) complex; required forthe sorting of some proteins to the outermembrane after import by the TOM complex 0.001110.00996&radic S000002323CDC9YDL164CverifiedDNA ligase found in the nucleus and mitochondria, an essentialenzyme that joins Okazaki fragments during DNAreplication; also acts in nucleotide excisionrepair, base excision repair, and recombination 0.001110.00996&radic&radic S000002691GCN2YDR283CverifiedProtein kinase, phosphorylates the alpha-subunit of translationinitiation factor eIF2 (Sui2p) in response tostarvation; activated by uncharged tRNAs andthe Gcn1p-Gcn20p complex 0.00110.00996&radic&radic&radic S000001490CAP1YKL007WverifiedAlpha subunit of the capping protein (CP) heterodimer (Cap1pand Cap2p) which binds to the barbed ends ofactin filaments preventing furtherpolymerization; localized predominantly tocortical actin patches 0.001110.00996&radic S000006322YPR118WVerifiedMethylthioribose-1-phosphate isomerase, catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway 0.00110.00996&radic&radic S000002749YDR341CVerifiedCytoplasmic arginyl-tRNA synthetase 0.00110.00996&radic&radic&radic&radic S000003358YGR126WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 0.001110.00996&radic&radic&radic&radic S000000803MNN1YER001WverifiedAlpha-1,3-mannosyltransferase, integral membrane glycoproteinof the Golgi complex, required for addition ofalpha1,3-mannose linkages to N-linked andO-linked oligosaccharides, one of five S.cerevisiae proteins of the MNN1 family 0.001110.00996&radic&radic&radic&radic S000002747FCF1YDR339CverifiedEssential nucleolar protein that is a component of the SSU(small subunit) processome involved in thepre-rRNA processing steps of 40S ribosomalsubunit biogenesis; contains a PINc domain;copurifies with Faf1p 0.001110.00996&radic&radic&radic&radic&radic S000002708PRO1YDR300CverifiedGamma-glutamyl kinase, catalyzes the first step in prolinebiosynthesis 0.001110.00996&radic&radic S000004433RPS1AYLR441CverifiedRibosomal protein 10 (rp10) of the small (40S) subunit; nearlyidentical to Rps1Bp and has similarity to ratS3a ribosomal protein 0.00110.00983&radic&radic S000002214MBP1YDL056WverifiedTranscription factor involved in regulation of cell cycleprogression from G1 to S phase, forms a complexwith Swi6p that binds to MluI cell cycle boxregulatory element in promoters of DNAsynthesis genes 0.00110.00983&radic&radic S000004257BOP2YLR267WuncharacterizedProtein of unknown function, overproduction suppresses a pam1slv3 double null mutation 0.00110.00983&radic&radic S000003520MAL13YGR288WverifiedMAL-activator protein, part of complex locus MAL1;nonfunctional in genomic reference strain S288C 0.00110.00983&radic&radic&radic&radic S000003007YGL039WVerifiedOxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol) 0.00110.00983&radic&radic&radic&radic S000001002YHL010CUncharacterizedPutative protein of unknown function, contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences 0.00110.00983&radic&radic S000002329UGA3YDL170WverifiedTranscriptional activator necessary for gamma-aminobutyrate(GABA)-dependent induction of GABA genes (suchas UGA1, UGA2, UGA4); zinc-finger transcriptionfactor of the Zn(2)-Cys(6) binuclear clusterdomain type; localized to the nucleus 0.00110.00983&radic&radic S000003736ACO2YJL200CuncharacterizedPutative mitochondrial aconitase isozyme; similarity to Aco1p,an aconitase required for the TCA cycle;expression induced during growth on glucose, byamino acid starvation via Gcn4p, and repressedon ethanol 0.00110.00983&radic S000005571TOM6YOR045WverifiedComponent of the TOM (translocase of outer membrane) complexresponsible for recognition and initial importsteps for all mitochondrially directedproteins; promotes assembly and stability ofthe TOM complex 0.00110.00983&radic&radic&radic&radic S000005426INP54YOL065CverifiedPhosphatidylinositol 4,5-bisphosphate 5-phosphatase with a rolein secretion, localizes to the endoplasmicreticulum via the C-terminal tail; lacks theSac1 domain and proline-rich region found inthe other 3 INP proteins 0.00110.0098&radic&radic&radic&radic S000003018TYW3YGL050WuncharacterizedHypothetical protein 0.00110.0098&radic&radic&radic&radic S000002458YDR051CUncharacterizedHypothetical protein 0.00110.0098&radic&radic S000001243RPN10YHR200WverifiedNon-ATPase base subunit of the 19S regulatory particle (RP) ofthe 26S proteasome; N-terminus plays a role inmaintaining the structural integrity of the RP;binds selectively to polyubiquitin chains;homolog of the mammalian S5a protein 0.00110.0098&radic&radic&radic&radic&radic S000003984MMP1YLL061WverifiedHigh-affinity S-methylmethionine permease, required forutilization of S-methylmethionine as a sulfursource; has similarity to S-adenosylmethioninepermease Sam3p 0.00110.0098&radic S000001355RSM25YIL093CverifiedMitochondrial ribosomal protein of the small subunit 0.00110.0098&radic&radic S000001857TUB2YFL037WverifiedBeta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p)to form tubulin dimer, which polymerizes toform microtubules 0.00110.00976&radic&radic&radic&radic S000000764UTR4YEL038WverifiedProtein of unknown function, found in both the cytoplasm andnucleus 0.00110.00976&radic&radic&radic&radic&radic S000003397MRPS35YGR165WverifiedMitochondrial ribosomal protein of the small subunit 0.00110.00976&radic&radic&radic&radic S000004216BUR2YLR226WverifiedCyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2pcomprise a CDK-cyclin complex involved intranscriptional regulation through itsphosphorylation of the carboxy-terminal domainof the largest subunit of RNA polymerase II 0.00110.00976&radic&radic&radic S000003188YGL220WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus 0.00110.00976&radic&radic&radic&radic&radic S000000451ENP1YBR247CverifiedProtein associated with U3 and U14 snoRNAs, required forpre-rRNA processing and 40S ribosomal subunitsynthesis; localized in the nucleus andconcentrated in the nucleolus 0.00110.00976&radic&radic&radic&radic&radic S000004456YLR464WUncharacterizedPutative protein of unknown function with similarity to helicases; YLR464W contains an intron and overlaps the verified gene YRF1-4/YLR466W and two dubious ORFs YLR463C and YLR465C 0.00110.00976&radic S000003510CWC22YGR278WverifiedEssential protein, component of a complex containing Cef1p, hassimilarity to S. pombe Cwf22p; putativespliceosomal component, based on computationalanalysis of large-scale protein-proteininteraction data 0.00110.00976&radic&radic&radic&radic S000002217RAD59YDL059CverifiedProtein involved in the repair of double-strand breaks in DNAduring vegetative growth via recombination andsingle-strand annealing; anneals complementarysingle-stranded DNA; homologous to Rad52p 0.00110.00976&radic&radic S000004888BUL1YMR275CverifiedUbiquitin-binding component of the Rsp5p E3-ubiquitin ligasecomplex, functional homolog of Bul2p,disruption causes temperature-sensitive growth,overexpression causes missorting of amino acidpermeases 0.00110.00976&radic&radic&radic&radic S000001662COY1YKL179CverifiedGolgi membrane protein with similarity to mammalian CASP;genetic interactions with GOS1 (encoding aGolgi snare protein) suggest a role in Golgifunction 0.00110.00976&radic&radic&radic S000003651ASF1YJL115WverifiedNucleosome assembly factor, involved in chromatin assembly anddisassembly, anti-silencing protein that causesderepression of silent loci when overexpressed 0.00110.00976&radic&radic S000002684PMP3YDR276CverifiedSmall plasma membrane protein related to a family of plantpolypeptides that are overexpressed under highsalt concentration or low temperature, notessential for viability, deletion causeshyperpolarization of the plasma membranepotential 0.00110.00976&radic&radic&radic S000006332ANT1YPR128CverifiedPeroxisomal adenine nucleotide transporter; involved inbeta-oxidation of medium-chain fatty acid;required for peroxisome proliferation 0.00110.00976&radic&radic S000003531ECM12YHR021W-AuncharacterizedNon-essential protein of unknown function 0.00110.00976&radic&radic S000003835MOG1YJR074WverifiedConserved nuclear protein that interacts with GTP-Gsp1p, whichis a Ran homolog of the Ras GTPase family, andstimulates nucleotide release, involved innuclear protein import, nucleotide release isinhibited by Yrb1p 0.00110.00976&radic S000005004ARP5YNL059CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes 0.00110.00976&radic S000002527TRM1YDR120CverifiedtRNA methyltransferase, localizes to both the nucleus andmitochondrion to produce the modified baseN2,N2-dimethylguanosine in tRNAs in bothcompartments 0.00110.00976&radic&radic&radic&radic S000003181SKI8YGL213CverifiedProtein involved in exosome mediated 3' to 5' mRNA degradationand translation inhibition of non-poly(A) mRNAsas well as double-strand break formation duringmeiotic recombination; required for repressingpropagation of dsRNA viruses 0.00110.00976&radic&radic&radic&radic S000005412SPE2YOL052CverifiedS-adenosylmethionine decarboxylase, required for thebiosynthesis of spermidine and spermine; cellslacking Spe2p require spermine or spermidinefor growth in the presence of oxygen but notwhen grown anaerobically 0.00110.00976&radic&radic S000001869BST1YFL025CverifiedGPI inositol deacylase of the ER that negatively regulatesCOPII vesicle formation, prevents production ofvesicles with defective subunits, required forproper discrimination between resident ERproteins and Golgi-bound cargo molecules 0.001090.00973&radic&radic&radic S000005788YOR262WUncharacterizedProtein required for cell viability 0.001090.00973&radic&radic&radic S000003034SGF73YGL066Wverified73 kDa subunit of SAGA histone acetyltransferase complex;involved in formation of the preinitiationcomplex assembly at promoters 0.001090.00973&radic&radic&radic&radic&radic S000004494RAD52YML032CverifiedProtein that stimulates strand exchange by facilitating Rad51pbinding to single-stranded DNA; annealscomplementary single-stranded DNA; involved inthe repair of double-strand breaks in DNAduring vegetative growth and meiosis 0.001090.00973&radic&radic&radic S000003088PRP43YGL120CverifiedRNA helicase in the DEAH-box family, functions in both RNApolymerase I and polymerase II transcriptmetabolism, involved in release of thelariat-intron from the spliceosome 0.001090.00952&radic S000002188PRP9YDL030WverifiedSubunit of the SF3a splicing factor complex, required forspliceosome assembly; acts after the formationof the U1 snRNP-pre-mRNA complex 0.001090.00952&radic&radic S000000743GTT3YEL017WuncharacterizedProtein of unknown function with a possible role in glutathionemetabolism, as suggested by computationalanalysis of large-scale protein-proteininteraction data; GFP-fusion protein localizesto the nuclear periphery 0.001090.00952&radic&radic&radic S000006290SUA7YPR086WverifiedTranscription factor TFIIB, a general transcription factorrequired for transcription initiation and startsite selection by RNA polymerase II 0.001090.00952&radic&radic S000001070DAP2YHR028CverifiedDipeptidyl aminopeptidase, synthesized as a glycosylatedprecursor; localizes to the vacuolar membrane;similar to Ste13p 0.001090.00952&radic&radic&radic&radic S000000097ECM15YBL001CverifiedNon-essential protein of unknown function, likely exists astetramer, may be regulated by the binding ofsmall-molecule ligands (possibly sulfate ions),may have a role in yeast cell-wall biogenesis 0.001090.00952&radic&radic&radic S000005639AZF1YOR113WverifiedZinc-finger transcription factor, involved in induction of CLN3transcription in response to glucose; geneticand physical interactions indicate a possiblerole in mitochondrial transcription or genomemaintenance 0.001090.00952&radic&radic&radic S000003698JJJ2YJL162CuncharacterizedProtein of unknown function, contains a J-domain, which is aregion with homology to the E. coli DnaJprotein 0.001090.00952&radic&radic&radic&radic&radic S000004928GLC8YMR311CverifiedRegulatory subunit of protein phosphatase 1 (Glc7p), involvedin glycogen metabolism and chromosomesegregation; proposed to regulate Glc7pactivity via conformational alteration;ortholog of the mammalian protein phosphataseinhibitor 2 0.001090.00952&radic&radic S000000836YER034WUncharacterizedHypothetical protein 0.001090.00952&radic&radic&radic S000000437PBP2YBR233WverifiedRNA binding protein with similarity to mammalian heterogeneousnuclear RNP K protein, involved in theregulation of telomere position effect andtelomere length 0.001090.00952&radic&radic&radic&radic S000001160ORC6YHR118CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing; may be phosphorylated by Cdc28p 0.001090.00952&radic&radic&radic&radic S000005041PHO23YNL097CverifiedProbable component of the Rpd3 histone deacetylase complex,involved in transcriptional regulation of PHO5;C-terminus has similarity to human candidatetumor suppressor p33(ING1) 0.001090.00952&radic&radic