Yfunc lets you browse current and predicted gene functions in yeast

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Prediction of GO:0006399 "tRNA metabolism"

GO branch: BP
Number of currently annotated genes: 112

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest Lum:MenadioneLum:TerbinafineLum:DoxycyclineLum:ChlorpromazineHuh:cytoplasmLum:Valproic AcidLum:PentamidineHuh:nucleusLum:NicardipineLum:DMSO S000003432ELP2YGR200CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;target of Kluyveromyces lactis zymocin &radic0.910331&radic&radic&radic&radic&radic S000006007ELP3YPL086CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;exhibits histone acetyltransferase activitythat is directed to histones H3 and H4;disruption confers resistance to K. lactiszymotoxin &radic0.892831&radic&radic&radic&radic&radic S000001104RPP1YHR062CverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends &radic0.809840.95833&radic&radic&radic&radic S000004376IKI3YLR384CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;maintains structural integrity of Elongator;homolog of human IKAP, mutations in which causefamilial dysautonomia (FD) &radic0.82610.95833&radic&radic&radic&radic&radic S000000371POP7YBR167CverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends &radic0.806150.95833&radic S000001230IKI1YHR187WverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;iki1 mutations confer resistance to the K.lactis toxin zymocin &radic0.826510.95833&radic S000000461POP4YBR257WverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends; binds to the RPR1 RNAsubunit in Rnase P &radic0.781920.95652&radic&radic&radic S000005165POP1YNL221CverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends; binds to the RPR1 RNAsubunit in Rnase P &radic0.767480.95004&radic&radic&radic&radic&radic S000006022ELP4YPL101WverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;required for Elongator structural integrity &radic0.751450.93975 S000000031POP5YAL033WverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends &radic0.725260.93455&radic&radic&radic&radic&radic S000005226POP3YNL282WverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends &radic0.714070.93143&radic&radic&radic S000003262POP6YGR030CverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends &radic0.712120.93088&radic&radic&radic&radic&radic&radic&radic S000003214GUS1YGL245WverifiedGlutamyl-tRNA synthetase (GluRS), forms a complex withmethionyl-tRNA synthetase (Mes1p) and Arc1p;complex formation increases the catalyticefficiency of both tRNA synthetases and ensurestheir correct localization to the cytoplasm &radic0.626820.88607&radic&radic&radic&radic&radic&radic S000000172ILS1YBL076CverifiedCytoplasmic isoleucine-tRNA synthetase, target of theG1-specific inhibitor reveromycin A 0.58290.86158&radic&radic&radic&radic S000000114POP8YBL018CverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends &radic0.567490.85332&radic&radic&radic&radic&radic S000003496MES1YGR264CverifiedMethionyl-tRNA synthetase, forms a complex with glutamyl-tRNAsynthetase (Gus1p) and Arc1p, which increasesthe catalytic efficiency of both tRNAsynthetases; also has a role in nuclear exportof tRNAs &radic0.544590.83569&radic&radic&radic&radic&radic S000002886SNM1YDR478WverifiedSubunit of RNase MRP, which cleaves pre-rRNA; not sharedbetween Rnase MRP and nuclear Rnase P, incontrast to all other Rnase MRP proteinsubunits; binds to the NME1 RNA subunit ofRnase MRP 0.53720.83347&radic S000004393DUS3YLR401CuncharacterizedDihydrouridine synthase, member of a widespread family ofconserved proteins including Smm1p, Dus1p, andDus4p; contains a consensus oleate responseelement (ORE) in its promoter region &radic0.496780.81205&radic&radic&radic&radic&radic S000005298SMM1YNR015WverifiedDihydrouridine synthase, member of a family of dihydrouridinesynthases including Dus1p, Smm1p, Dus3p, andDus4p; modifies uridine residues at position 20of cytoplasmic tRNAs &radic0.48260.80273&radic&radic S000001551NUP100YKL068WverifiedSubunit of the nuclear pore complex (NPC) that is localized toboth sides of the pore; contains a repetitiveGLFG motif that interacts with mRNA exportfactor Mex67p and with karyopherin Kap95p;homologous to Nup116p 0.47760.79902&radic&radic&radic S000004545DUS1YML080WverifiedDihydrouridine synthase, member of a widespread family ofconserved proteins including Smm1p, Dus3p, andDus4p; modifies pre-tRNA(Phe) at U17 &radic0.467070.79216&radic S000005243TRF5YNL299WverifiedPoly (A) polymerase involved in nuclear RNA quality controlbased on: homology with Trf4p, geneticinteractions with TRF4 mutants, physicalinteraction with Mtr4p (TRAMP subunit), and bydirect assay; disputed role as a sigma DNApolymerase 0.457150.78738&radic&radic&radic&radic&radic S000002334AIR2YDL175CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p; may regulatemethylation of Npl3p, which modulates Npl3pfunction in mRNA processing and export; hassimilarity to Air1p &radic0.450210.78445&radic S000001341AIR1YIL079CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p to regulate methylationof Npl3p, which modulates Npl3p function inmRNA processing and export; has similarity toAir2p &radic0.440530.77732&radic&radic&radic&radic S000004095SEN2YLR105CverifiedSubunit of the tRNA splicing endonuclease, which is composed ofSen2p, Sen15p, Sen34p, and Sen54p; Sen2pcontains the active site for tRNA 5' splicesite cleavage and has similarity to Sen34p andto Archaeal tRNA splicing endonuclease &radic0.433330.77078 S000003417TYS1YGR185CverifiedCytoplasmic tyrosyl-tRNA synthetase, class I aminoacyl-tRNAsynthetase that aminoacylates tRNA(Tyr),required for cytoplasmic protein synthesis,interacts with positions 34 and 35 of theanticodon of tRNATyr &radic0.404410.74895&radic&radic&radic&radic&radic&radic S000005427RIB2YOL066CverifiedDRAP deaminase, catalyzes the third step of the riboflavinbiosynthesis pathway; cytoplasmic tRNApseudouridine synthase involved inpseudouridylation of cytoplasmic tRNAs atposition 32 &radic0.398170.74468&radic&radic&radic&radic&radic S000004650NUP116YMR047CverifiedSubunit of the nuclear pore complex (NPC) that is localized toboth sides of the pore; contains a repetitiveGLFG motif that interacts with mRNA exportfactor Mex67p and with karyopherin Kap95p;homologous to Nup100p &radic0.39720.74442&radic&radic S000002691GCN2YDR283CverifiedProtein kinase, phosphorylates the alpha-subunit of translationinitiation factor eIF2 (Sui2p) in response tostarvation; activated by uncharged tRNAs andthe Gcn1p-Gcn20p complex 0.394330.74118&radic&radic&radic&radic&radic S000002430SES1YDR023WverifiedCytosolic seryl-tRNA synthetase, class II aminoacyl-tRNAsynthetase that aminoacylates tRNA(Ser),displays tRNA-dependent amino acid recognitionwhich enhances discrimination of the serinesubstrate, interacts with peroxin Pex21p &radic0.369850.71898&radic S000001340THS1YIL078WverifiedThreonyl-tRNA synthetase, essential cytoplasmic protein 0.364240.71135&radic&radic&radic&radic&radic&radic S000002194PUS9YDL036CverifiedMitochondrial tRNA pseudouridine synthase involved inpseudouridylation of mitochondrial tRNAs atposition 32 &radic0.3620.70912&radic&radic S000003060NUP145YGL092WverifiedEssential nucleoporin, catalyzes its own cleavage in vivo togenerate a C-terminal fragment that assemblesinto the Nup84p subcomplex of the nuclear porecomplex, and an N-terminal fragment of unknownfunction that is homologous to Nup100p &radic0.34510.68642&radic&radic&radic&radic S000000066SEN34YAR008WverifiedSubunit of the tRNA splicing endonuclease, which is composed ofSen2p, Sen15p, Sen34p, and Sen54p; Sen34pcontains the active site for tRNA 3' splicesite cleavage and has similarity to Sen2p andto Archaeal tRNA splicing endonuclease &radic0.341770.68342&radic&radic&radic S000005191YNL247WUncharacterizedProtein required for cell viability &radic0.312980.64747&radic&radic&radic&radic&radic&radic S000003450CRM1YGR218WverifiedMajor karyopherin, involved in export of proteins, RNAs, andribosomal subunits from the nucleus 0.309790.64326&radic&radic&radic&radic&radic S000005333LYS9YNR050CverifiedSaccharopine dehydrogenase (NADP+, L-glutamate-forming);catalyzes the formation of saccharopine fromalpha-aminoadipate 6-semialdehyde, which is theseventh step in lysine biosynthesis pathway 0.294220.62568&radic S000002749YDR341CVerifiedCytoplasmic arginyl-tRNA synthetase 0.289950.62039&radic&radic&radic&radic S000005457WRS1YOL097CverifiedCytoplasmic tryptophanyl-tRNA synthetase, aminoacylatestryptophanyl-tRNA &radic0.286610.61817&radic S000006133PUS1YPL212CverifiedtRNA:pseudouridine synthase, introduces pseudouridines atpositions 26-28, 34-36, 65, and 67 of tRNA;nuclear protein that appears to be involved intRNA export; also acts on U2 snRNA &radic0.281720.61124&radic&radic&radic&radic S000005317SOL1YNR034WverifiedProtein with a possible role in tRNA export; shows similarityto 6-phosphogluconolactonase non-catalyticdomains but does not exhibit this enzymaticactivity; homologous to Sol2p, Sol3p, and Sol4p &radic0.280580.61042&radic&radic S000001053DIA4YHR011WverifiedProbable mitochondrial seryl-tRNA synthetase, mutant displaysincreased invasive and pseudohyphal growth &radic0.27480.60347&radic&radic&radic S000002676MSW1YDR268WverifiedMitochondrial tryptophanyl-tRNA synthetase &radic0.258660.58226&radic&radic&radic&radic&radic S000001062YHR020WUncharacterizedPutative protein of unknown function, has similarity to proline-tRNA ligase; YHR020W is an essential gene &radic0.257090.58037&radic&radic&radic&radic S000005694GLN4YOR168WverifiedGlutamine tRNA synthetase, monomeric class I tRNA synthetasethat catalyzes the specific glutaminylation oftRNA(Glu); N-terminal domain proposed to beinvolved in enzyme-tRNA interactions &radic0.256550.57983&radic&radic&radic&radic&radic S000005393MSE1YOL033WverifiedMitochondrial glutamyl-tRNA synthetase, encoded by a nucleargene &radic0.256390.57962&radic&radic&radic&radic S000006018MSY1YPL097WverifiedMitochondrial tyrosyl-tRNA synthetase &radic0.256060.5792&radic&radic S000000889YER087WUncharacterizedHypothetical protein 0.254740.57712&radic&radic&radic&radic&radic&radic S000003403MSM1YGR171CverifiedMitochondrial methionyl-tRNA synthetase (MetRS), functions as amonomer in mitochondrial protein synthesis;functions similarly to cytoplasmic MetRSalthough the cytoplasmic form contains azinc-binding domain not found in Msm1p &radic0.254380.57699&radic&radic&radic S000004397DUS4YLR405WuncharacterizedDihydrouridine synthase, member of a widespread family ofconserved proteins including Smm1p, Dus1p, andDus3p &radic0.25210.57428&radic&radic&radic&radic&radic&radic S000005484TRM11YOL124CverifiedCatalytic subunit of an adoMet-dependent tRNA methyltransferasecomplex (Trm11p-Trm112p), required for themethylation of the guanosine nucleotide atposition 10 (m2G10) in tRNAs; contains a THUMPdomain and a methyltransferase domain &radic0.251590.57327&radic S000003744NUC1YJL208CverifiedMajor mitochondrial nuclease, has RNAse and DNA endo- andexonucleolytic activities; has a role inmitochondrial recombination 0.250280.5708&radic&radic&radic&radic S000003577NSP1YJL041WverifiedEssential component of the nuclear pore complex, which mediatesnuclear import and export 0.247080.56562 S000006081CDC60YPL160WverifiedCytosolic leucyl tRNA synthetase, ligates leucine to theappropriate tRNA &radic0.236460.55126&radic&radic&radic&radic S000000325GRS1YBR121CverifiedCytoplasmic and mitochondrial glycyl-tRNA synthase that ligatesglycine to the cognate anticodon bearing tRNA;transcription termination factor that mayinteract with the 3'-end of pre-mRNA to promote3'-end formation &radic0.235350.55051&radic S000006285GRS2YPR081CverifiedProtein with sequence similarity to Grs1p, which is aglycyl-tRNA synthetase; cannot substitute forGrs1p; possible pseudogene that is expressed atvery low levels &radic0.233730.54867&radic S000005329TRM112YNR046WverifiedSubunit of an adoMet-dependent tRNA methyltransferase (MTase)complex (Trm11p-Trm112p), required for themethylation of the guanosine nucleotide atposition 10 (m2G10) in tRNAs; putative zincbinding subunit of other MTase-related proteins &radic0.231170.54527&radic&radic S000003326VAS1YGR094WverifiedMitochondrial and cytoplasmic valyl-tRNA synthetase &radic0.228060.54104&radic&radic&radic&radic S000001133MSR1YHR091CverifiedMitochondrial arginyl-tRNA synthetase &radic0.224190.53506&radic&radic&radic&radic&radic S000001872FRS2YFL022CverifiedAlpha subunit of cytoplasmic phenylalanyl-tRNA synthetase,forms a tetramer with Frs1p to form activeenzyme; evolutionarily distant frommitochondrial phenylalanyl-tRNA synthetasebased on protein sequence, but substratebinding is similar &radic0.221840.53153&radic&radic&radic&radic&radic S000004374NAM2YLR382CverifiedMitochondrial leucyl-tRNA synthetase, also has a direct role insplicing of several mitochondrial group Iintrons; indirectly required for mitochondrialgenome maintenance &radic0.218590.52692 S000006237HTS1YPR033CverifiedCytoplasmic and mitochondrial histidine tRNA synthetase;encoded by a single nuclear gene that specifiestwo messages; efficient mitochondriallocalization requires both a presequence and anamino-terminal sequence &radic0.215650.52217&radic S000003065SRM1YGL097WverifiedNucleotide exchange factor for Gsp1p, localizes to the nucleus,required for nucleocytoplasmic trafficking ofmacromolecules; potentially phosphorylated byCdc28p 0.210790.51386&radic S000003436ADE3YGR204WverifiedCytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase,involved in single carbon metabolism andrequired for biosynthesis of purines,thymidylate, methionine, and histidine 0.210810.51386&radic&radic S000005961ISM1YPL040CverifiedMitochondrial isoleucyl-tRNA synthetase, null mutant isdeficient in respiratory growth &radic0.206380.50658&radic&radic&radic&radic&radic S000001895DEG1YFL001WverifiedNon-essential tRNA:pseudouridine synthase, introducespseudouridines at position 38 or 39 in tRNA,important for maintenance of translationefficiency and normal cell growth, localizes toboth the nucleus and cytoplasm 0.20560.50483&radic S000001677MST1YKL194CverifiedMitochondrial threonyl-tRNA synthetase &radic0.200530.49753 S000003401PUS6YGR169CverifiedPseudouridine synthase responsible for modification ofcytoplasmic and mitochondrial tRNAs at position31; mutation of Asp168 to Ala abolishes enzymeactivity; not essential for viability &radic0.197650.49228&radic&radic S000001710PAP1YKR002WverifiedPoly(A) polymerase, one of three factors required for mRNA3'-end polyadenylation, forms multiproteincomplex with polyadenylation factor I (PF I),also required for mRNA nuclear export; may alsopolyadenylate rRNAs 0.183280.46793&radic&radic&radic&radic&radic&radic S000000618SLM5YCR024CverifiedMitochondrial asparaginyl-tRNA synthetase 0.176590.4576 S000002790RPP2BYDR382WverifiedRibosomal protein P2 beta, a component of the ribosomal stalk,which is involved in the interaction betweentranslational elongation factors and theribosome; regulates the accumulation of P1(Rpp1Ap and Rpp1Bp) in the cytoplasm 0.175940.45637&radic&radic S000002274NUP84YDL116WverifiedSubunit of the nuclear pore complex (NPC), forms a subcomplexwith Nup85p, Nup120p, Nup145p-C, Sec13p, andSeh1p that plays a role in nuclear mRNA exportand NPC biogenesis 0.171560.44774 S000005686MTR10YOR160WverifiedNuclear import receptor, mediates the nuclear localization ofproteins involved in mRNA-nucleus export 0.171150.44712&radic&radic&radic&radic&radic S000004339KAP95YLR347CverifiedKaryopherin beta, forms a dimeric complex with Srp1p (Kap60p)that mediates nuclear import of cargo proteinsvia a nuclear localization signal (NLS),interacts with nucleoporins to guide transportacross the nuclear pore complex 0.169880.44516&radic&radic&radic&radic&radic S000005228MRPL10YNL284CverifiedMitochondrial ribosomal protein of the large subunit; appearsas two protein spots (YmL10 and YmL18) ontwo-dimensional SDS gels 0.168820.44292 S000001061DED81YHR019CverifiedCytosolic asparaginyl-tRNA synthetase, required for proteinsynthesis, catalyzes the specific attachment ofasparagine to its cognate tRNA &radic0.16630.43882&radic&radic S000004155PUS5YLR165CverifiedPseudouridine synthase, catalyzes only the formation ofpseudouridine (Psi)-2819 in mitochondrial 21SrRNA; not essential for viability 0.164380.43495&radic&radic&radic&radic&radic S000002444KRS1YDR037WverifiedLysyl-tRNA synthetase; also identified as a negative regulatorof general control of amino acid biosynthesis &radic0.162060.43098 S000006251MSF1YPR047WverifiedMitochondrial phenylalanyl-tRNA synthetase alpha subunit,active as a monomer, unlike the cytoplasmicsubunit which is active as a dimer complexed toa beta subunit dimer; similar to the alphasubunit of E. coli phenylalanyl-tRNA synthetase 0.161310.42974 S000003858JJJ3YJR097WverifiedProtein of unknown function, contains a J-domain, which is aregion with homology to the E. coli DnaJprotein 0.159180.42546&radic&radic S000006111NAB3YPL190CverifiedSingle stranded DNA binding protein; acidic ribonucleoprotein;required for termination of non-poly(A)transcripts and efficient splicing; interactswith Nrd1p 0.158750.42451&radic&radic&radic&radic S000005017MSK1YNL073WverifiedMitochondrial lysine-tRNA synthetase, required for import ofboth aminoacylated and deacylated forms oftRNA(Lys) into mitochondria &radic0.153750.41463 S000004165CBF5YLR175WverifiedPseudouridine synthase catalytic subunit of box H/ACA smallnucleolar ribonucleoprotein particles(snoRNPs), acts on both large and small rRNAsand on snRNA U2 0.152580.41262&radic&radic&radic&radic S000000226POA1YBR022WverifiedPhosphatase that is highly specific for ADP-ribose1''-phosphate, a tRNA splicing metabolite; mayhave a role in regulation of tRNA splicing &radic0.149580.40794 S000004235CDD1YLR245CverifiedCytidine deaminase; catalyzes the modification of cytidine touridine in vitro but native RNA substrates havenot been identified, localizes to both thenucleus and cytoplasm 0.147240.40301&radic&radic S000003941DPS1YLL018CverifiedCytoplasmic aspartyl-tRNA synthetase, homodimeric enzyme thatcatalyzes the specific aspartylation oftRNA(Asp); class II aminoacyl tRNA synthetase;binding to its own mRNA may conferautoregulation 0.146260.40105&radic&radic&radic S000002816ADE8YDR408CverifiedPhosphoribosyl-glycinamide transformylase, catalyzes a step inthe 'de novo' purine nucleotide biosyntheticpathway 0.142970.3948&radic&radic&radic&radic&radic S000004929ELP6YMR312WverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;required for Elongator structural integrity &radic0.14180.39231 S000000117HAP3YBL021CverifiedSubunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5pCCAAT-binding complex, a transcriptionalactivator and global regulator of respiratorygene expression; contains sequencescontributing to both complex assembly and DNAbinding 0.140270.38928&radic&radic&radic&radic&radic&radic&radic S000001790NUP133YKR082WverifiedSubunit of the Nup84p subcomplex of the nuclear pore complex(NPC), localizes to both sides of the NPC,required to establish a normalnucleocytoplasmic concentration gradient of theGTPase Gsp1p 0.140.3888 S000005527RRP6YOR001WverifiedExonuclease component of the nuclear exosome; contributes tothe quality-control system that retains anddegrades aberrant mRNAs in the nucleus 0.139090.38701&radic&radic&radic&radic&radic S000003586MTR4YJL050WverifiedDead-box family ATP dependent helicase required for mRNA exportfrom the nucleus; co-factor of the exosomecomplex, required for 3' end formation of 5.8SrRNA &radic0.138730.38639&radic S000004464TRM12YML005WverifiedS-adenosylmethionine-dependent methyltransferase of the sevenbeta-strand family; required for wybutosineformation in phenylalanine-accepting tRNA &radic0.133990.37784&radic&radic&radic&radic&radic S000006025MSD1YPL104WverifiedMitochondrial aspartyl-tRNA synthetase, required for acylationof aspartyl-tRNA; yeast and bacterialaspartyl-, asparaginyl-, and lysyl-tRNAsynthetases contain regions with high sequencesimilarity, suggesting a common ancestral gene 0.133720.37702&radic&radic&radic S000005475PAP2YOL115WverifiedCatalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), anuclear poly (A) polymerase complex involved inRNA quality control; catalyzes polyadenylationof unmodified tRNAs, and snoRNA and rRNAprecursors; disputed role as a DNA polymerase &radic0.133570.37701&radic S000001187DCD1YHR144CverifiedDeoxycytidine monophosphate (dCMP) deaminase required for dCTPand dTTP synthesis; expression is NOT cellcycle regulated 0.131320.37255&radic S000006266FCY1YPR062WverifiedCytosine deaminase, zinc metalloenzyme that catalyzes thehydrolytic deamination of cytosine to uracil;of biomedical interest because it alsocatalyzes the deamination of 5-fluorocytosine(5FC) to form anticancer drug 5-fluorouracil(5FU) 0.131210.37214&radic&radic S000000718SOL2YCR073W-AverifiedProtein with a possible role in tRNA export; shows similarityto 6-phosphogluconolactonase non-catalyticdomains but does not exhibit this enzymaticactivity; homologous to Sol1p, Sol3p, and Sol4p &radic0.129260.36839&radic S000002923SLF1YDR515WverifiedRNA binding protein that associates with polysomes; proposed tobe involved in regulating mRNA translation;involved in the copper-dependent mineralizationof copper sulfide complexes on cell surface incells cultured in copper salts 0.129280.36839&radic S000002988GET1YGL020CverifiedSubunit of the GET complex; required for the retrieval of HDELproteins from the Golgi to the ER in an ERD2dependent fashion and for normal mitochondrialmorphology and inheritance 0.12880.36762 S000004476TRM9YML014WverifiedtRNA methyltransferase, catalyzes the esterification ofmodified uridine nucleotides in tRNAs, creating5-methylcarbonylmethyluridine in tRNA(Arg3) and5-methylcarbonylmethyl-2-thiouridine intRNA(Glu); may have a role in stress response &radic0.127450.3644&radic&radic&radic&radic&radic&radic S000003163GCN1YGL195WverifiedPositive regulator of the Gcn2p kinase activity, forms acomplex with Gcn20p; proposed to stimulateGcn2p activation by an uncharged tRNA 0.12710.36391&radic S000000120NCL1YBL024WverifiedS-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase,methylates cytosine to m5C at several positionsin tRNAs and intron-containing pre-tRNAs;similar to Nop2p and human proliferationassociated nucleolar protein p120 &radic0.123450.35649&radic&radic&radic&radic S000003104MRM2YGL136CverifiedMitochondrial 21S rRNA methyltransferase, required formethylation of U(2791) in 21S rRNA; MRM2deletion confers thermosensitive respirationand loss of mitochondrial DNA; has similarityto Spb1p and Trm7p, and to E. coli FtsJ/RrmJ 0.122520.35459 S000002495SLU7YDR088CverifiedRNA splicing factor, required for ATP-independent portion of2nd catalytic step of spliceosomal RNAsplicing; interacts with Prp18p; contains zincknuckle domain 0.12070.35024&radic&radic&radic&radic&radic&radic&radic S000005005NOP2YNL061WverifiedProbable RNA m(5)C methyltransferase, essential for processingand maturation of 27S pre-rRNA and largeribosomal subunit biogenesis; localized to thenucleolus; constituent of 66S pre-ribosomalparticles 0.120740.35024&radic S000004732STO1YMR125WverifiedLarge subunit of the nuclear mRNA cap-binding protein complex,interacts with Npl3p to carry nuclear poly(A)+mRNA to cytoplasm; also involved in nuclearmRNA degradation and telomere maintenance;orthologous to mammalian CBP80 0.11920.34711&radic S000000559SPB1YCL054WverifiedAdoMet-dependent methyltransferase involved in rRNA processingand 60S ribosomal subunit maturation;methylates G2922 in the tRNA docking site ofthe large subunit rRNA and in the absence ofsnR52, U2921; suppressor of PAB1 mutants 0.118870.3464&radic&radic&radic S000004467ERG6YML008CverifiedDelta(24)-sterol C-methyltransferase, converts zymosterol tofecosterol in the ergosterol biosyntheticpathway by methylating position C-24; localizedto both lipid particles and mitochondrial outermembrane 0.11720.34301&radic&radic&radic&radic S000003322UTP22YGR090WuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.116890.34233&radic&radic&radic&radic&radic S000001112TRM5YHR070WverifiedtRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacentto the anticodon that has a role in preventionof frameshifting; highly conserved acrossArchaea, Bacteria, and Eukarya &radic0.111280.32988&radic&radic&radic&radic&radic&radic&radic S000003803NUP85YJR042WverifiedSubunit of the Nup84p subcomplex of the nuclear pore complex(NPC), required for assembly of the subcomplexand also for formation of the nucleocytoplasmicGsp1p concentration gradient that plays a rolein nuclear trafficking 0.110170.32704 S000001217ENO2YHR174WverifiedEnolase II, a phosphopyruvate hydratase that catalyzes theconversion of 2-phosphoglycerate tophosphoenolpyruvate during glycolysis and thereverse reaction during gluconeogenesis;expression is induced in response to glucose 0.110090.32692&radic S000001377NUP159YIL115CverifiedSubunit of the nuclear pore complex that is found exclusivelyon the cytoplasmic side, forms a subcomplexwith Nup82p and Nsp1p, required for mRNA export 0.108870.32418 S000005883YOR356WUncharacterizedHypothetical protein 0.10870.32383&radic&radic&radic S000004327NUP2YLR335WverifiedProtein involved in nucleocytoplasmic transport, binds toeither the nucleoplasmic or cytoplasmic facesof the nuclear pore complex depending onRan-GTP levels; also has a role in chromatinorganization 0.108330.323&radic&radic&radic S000004693YMR087WVerifiedPutative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain &radic0.102450.30891 S000000288MIS1YBR084WverifiedMitochondrial C1-tetrahydrofolate synthase, involved ininterconversion between different oxidationstates of tetrahydrofolate (THF); providesactivities of formyl-THF synthetase,methenyl-THF cyclohydrolase, and methylene-THFdehydrogenase &radic0.098080.29754 S000000542SRO9YCL037CverifiedCytoplasmic RNA-binding protein that associates withtranslating ribosomes; involved in hemeregulation of Hap1p as a component of the HMCcomplex, also involved in the organization ofactin filaments; contains a La motif 0.097840.29711&radic&radic&radic&radic&radic S000005230CUS2YNL286WverifiedProtein that binds to U2 snRNA and Prp11p, may be involved inU2 snRNA folding; contains two RNA recognitionmotifs (RRMs) 0.097180.29564&radic&radic&radic&radic&radic S000004106MSL5YLR116WverifiedComponent of the commitment complex, which defines the firststep in the splicing pathway; essential proteinthat interacts with Mud2p and Prp40p, forming abridge between the intron ends; also involvedin nuclear retention of pre-mRNA 0.096190.29315&radic&radic&radic&radic&radic S000005199GIS2YNL255CverifiedProtein with seven cysteine-rich CCHC zinc-finger motifs,similar to human CNBP, proposed to be involvedin the RAS/cAMP signaling pathway 0.095830.29205&radic&radic&radic&radic&radic&radic&radic S000003597NUP82YJL061WverifiedSubunit of the nuclear pore complex (NPC), forms a subcomplexwith Nup159p and Nsp1p, interacts with Nup116pand is required for proper localization ofNup116p in the NPC 0.095730.29191 S000003031PUS2YGL063WverifiedPutative pseudouridine synthase &radic0.095270.29064&radic&radic&radic&radic S000004390SKI2YLR398CverifiedPutative RNA helicase, involved in exosome mediated 3' to 5'mRNA degradation and translation inhibition ofnon-poly(A) mRNAs; forms complex with Ski3p andSki8p; required for repressing propagation ofdsRNA viruses 0.093580.28571&radic&radic&radic&radic&radic&radic S000005577YOR051CUncharacterizedNuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts 0.09340.28528&radic&radic&radic&radic&radic&radic&radic S000003388PTI1YGR156WverifiedPta1p Interacting protein 0.092180.28202&radic&radic&radic&radic&radic&radic S000005336NOG2YNR053CverifiedPutative GTPase that associates with pre-60S ribosomal subunitsin the nucleolus and is required for theirnuclear export and maturation 0.091830.28112&radic S000003480SOL4YGR248Wverified6-phosphogluconolactonase with similarity to Sol3p 0.091570.28042&radic&radic S000007587KTI11YBL071W-AverifiedProtein required for synthesis of diphthamide, a modifiedhistidine residue of translation elongationfactor 2; functions with Dph1p, Dph2p, Jjj3p,and Dph5p; required, with Elongator complex,for modification of wobble nucleosides in tRNA &radic0.090450.27738&radic&radic S000004067FMP25YLR077WuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.089030.2735&radic&radic&radic&radic&radic S000001898NIC96YFR002WverifiedComponent of the nuclear pore complex, required for nuclearpore formation; forms a subcomplex with Nsp1p,Nup57p, and Nup49p 0.088550.27191 S000000808NUG1YER006WverifiedGTPase that associates with nuclear 60S pre-ribosomes, requiredfor export of 60S ribosomal subunits from thenucleus 0.085560.26424&radic&radic&radic&radic&radic&radic S000001206SOL3YHR163Wverified6-phosphogluconolactonase, catalyzes the second step of thepentose phosphate pathway; weak multicopysuppressor of los1-1 mutation; homologous toSol2p and Sol1p 0.085360.26347&radic&radic S000004018ADE16YLR028CverifiedEnzyme of 'de novo' purine biosynthesis containing both5-aminoimidazole-4-carboxamide ribonucleotidetransformylase and inosine monophosphatecyclohydrolase activities, isozyme of Ade17p;ade16 ade17 mutants require adenine andhistidine 0.084760.26216&radic&radic&radic&radic&radic S000003563RNR2YJL026WverifiedRibonucleotide-diphosphate reductase (RNR), small subunit; theRNR complex catalyzes the rate-limiting step indNTP synthesis and is regulated by DNAreplication and DNA damage checkpoint pathwaysvia localization of the small subunits 0.084740.26216&radic&radic&radic&radic&radic&radic&radic S000005062DCP2YNL118CverifiedCatalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex,which removes the 5' cap structure from mRNAsprior to their degradation; member of the Nudixhydrolase family 0.084080.2604 S000004308TAD3YLR316CverifiedSubunit of tRNA-specific adenosine-34 deaminase, forms aheterodimer with Tad2p that converts adenosineto inosine at the wobble position of severaltRNAs &radic0.082470.25591&radic&radic&radic&radic&radic&radic&radic&radic&radic S000001542MPE1YKL059CverifiedEssential conserved subunit of CPF (cleavage andpolyadenylation factor), plays a role in 3' endformation of mRNA via the specific cleavage andpolyadenylation of pre-mRNA, contains aputative RNA-binding zinc knuckle motif 0.081850.25392&radic&radic&radic&radic&radic&radic&radic S000004050FRS1YLR060WverifiedBeta subunit of cytoplasmic phenylalanyl-tRNA synthetase, formsa tetramer with Frs2p to generate activeenzyme; sequence is evolutionarily distant frommitochondrial phenylalanyl-tRNA synthetase(Msf1p), but substrate binding is similar &radic0.081050.25149&radic&radic S000005133SRP1YNL189WverifiedKaryopherin alpha homolog, forms a dimer with karyopherin betaKap95p to mediate import of nuclear proteins,binds the nuclear localization signal of thesubstrate during import; may also play a rolein regulation of protein degradation 0.080950.25149&radic&radic&radic&radic S000006311YTH1YPR107CverifiedEssential RNA-binding component of cleavage and polyadenylationfactor, contains five zinc fingers; requiredfor pre-mRNA 3'-end processing andpolyadenylation 0.080630.25079&radic&radic&radic&radic S000004967YNL022CUncharacterizedPutative protein of unknown function with seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to a single spot in the nucleus; YNL022C is not an essential gene 0.079360.24709&radic&radic S000000398SOY1YBR194WuncharacterizedProtein proposed to be associated with the nuclear pore complex 0.077570.24248&radic&radic&radic&radic S000005195NRD1YNL251CverifiedRNA-binding protein that interacts with the C-terminal domainof the RNA polymerase II large subunit(Rpo21p), required for transcriptiontermination and 3' end maturation ofnonpolyadenylated RNAs 0.076810.24019&radic&radic&radic&radic S000002840NPL3YDR432WverifiedRNA-binding protein that carries poly(A)+ mRNA from the nucleusinto the cytoplasm; phosphorylation by Sky1p inthe cytoplasm may promote release of mRNAs 0.076230.23874&radic&radic&radic&radic&radic S000000909GLE2YER107CverifiedComponent of the nuclear pore complex required forpolyadenylated RNA export but not for proteinimport, homologous to S. pombe Rae1p 0.075970.23806&radic S000002366GLE1YDL207WverifiedCytoplasmic nucleoporin required for polyadenylated RNA exportbut not for protein import; component of Nup82pnuclear pore subcomplex; contains a nuclearexport signal 0.073890.23223 S000003572TAD2YJL035CverifiedSubunit of tRNA-specific adenosine-34 deaminase, forms aheterodimer with Tad3p that converts adenosineto inosine at the wobble position of severaltRNAs &radic0.072270.22799&radic&radic S000000221KAP104YBR017CverifiedTransportin, cytosolic karyopherin beta 2 involved in deliveryof heterogeneous nuclear ribonucleoproteins tothe nucleoplasm, binds rg-nuclear localizationsignals on Nab2p and Hrp1p, plays a role incell-cycle progression 0.071260.22512&radic&radic S000000682CSM1YCR086WverifiedNucleolar protein that forms a complex with Lrs4p which bindsMam1p at kinetochores during meiosis I tomediate accurate chromosome segregation, may beinvolved in premeiotic DNA replication;possible role in telomere maintenance 0.071220.22489 S000001669MTR2YKL186CverifiedmRNA transport regulator, essential nuclear protein; Mex67p andMtr2p form a mRNA export complex which binds toRNA 0.07050.22302&radic&radic&radic&radic S000000063NUP60YAR002WverifiedSubunit of the nuclear pore complex (NPC), functions to anchorNup2p to the NPC in a process controlled by thenucleoplasmic concentration of Gsp1p-GTP;potential Cdc28p substrate; involved intelomere maintenance 0.070140.22201&radic&radic&radic&radic S000000484SAF1YBR280CverifiedF-Box protein involved in proteasome-dependent degradation ofAah1p during entry of cells into quiescence;interacts with Skp1 0.069560.22036 S000002299RPO21YDL140CverifiedRNA polymerase II largest subunit B220, part of central core;phosphorylation of C-terminal heptapeptiderepeat domain regulates association withtranscription and splicing factors; similar tobacterial beta-prime 0.068040.21631&radic S000004614CLU1YMR012WverifiedeIF3 component of unknown function; deletion causes defects inmitochondrial organization but not in growth ortranslation initiation, can rescue cytokinesisand mitochondrial organization defects of theDictyostelium cluA- mutant 0.067990.21619&radic&radic S000002360TRM8YDL201WverifiedSubunit of a tRNA methyltransferase complex composed of Trm8pand Trm82p that catalyzes 7-methylguanosinemodification of tRNA &radic0.066850.21285&radic S000005509DCP1YOL149WverifiedSubunit of the Dcp1p-Dcp2p decapping enzyme complex, whichremoves the 5' cap structure from mRNAs priorto their degradation; enhances the activity ofcatalytic subunit Dcp2p; regulated by DEAD boxprotein Dhh1p 0.066780.21261 S000004985YNL040WUncharacterizedPutative protein of unknown function with strong similarity to alanyl-tRNA synthases from Eubacteria; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL040W is not an essential gene 0.066490.21176&radic S000006158SUI3YPL237WverifiedBeta subunit of the translation initiation factor eIF2,involved in the identification of the startcodon; proposed to be involved in mRNA binding 0.065770.20976&radic&radic S000001695SAC1YKL212WverifiedLipid phosphoinositide phosphatase of the ER and Golgi,involved in protein trafficking and secretion 0.065390.2088&radic&radic&radic&radic S000002271ATG20YDL113CverifiedProtein required for transport of aminopeptidase I (Lap4p)through the cytoplasm-to-vacuole targetingpathway; bindsphosphatidylinositol-3-phosphate, involved inlocalization of membranes to thepreautophagosome, potential Cdc28p substrate 0.065280.20848 S000001788MTD1YKR080WverifiedNAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase,plays a catalytic role in oxidation ofcytoplasmic one-carbon units; expression isregulated by Bas1p and Bas2p, repressed byadenine, and may be induced by inositol andcholine 0.063340.20284&radic&radic&radic&radic&radic&radic&radic&radic S000002547MTQ2YDR140WuncharacterizedS-adenosylmethionine-dependent methyltransferase of the sevenbeta-strand family; methylates release factoreRF1 (Sup45p) in vitro; is not an essentialgene; similar to E.coli PrmC 0.062110.1992&radic&radic&radic&radic&radic&radic&radic S000001593KTI12YKL110CverifiedProtein that plays a role, with Elongator complex, inmodification of wobble nucleosides in tRNA;involved in sensitivity to G1 arrest induced byzymocin; interacts with chromatin throughoutthe genome; also interacts with Cdc19p &radic0.061820.19826&radic&radic&radic&radic&radic&radic&radic S000004924GAS1YMR307WverifiedBeta-1.3-glucanosyltransferase, required for cell wallassembly; localizes to the cell surface via aglycosylphosphatidylinositol (GPI) anchor 0.061670.19776&radic&radic&radic&radic S000001540NUP120YKL057CverifiedSubunit of the Nup84p subcomplex of the nuclear pore complex(NPC), required for even distribution of NPCsaround the nuclear envelope, involved inestablishment of a normal nucleocytoplasmicconcentration gradient of the GTPase Gsp1p 0.061590.19746&radic&radic&radic&radic&radic S000003306SMD1YGR074WverifiedCore Sm protein Sm D1; part of heteroheptameric complex (withSmb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D1 0.061320.19677&radic&radic&radic&radic&radic S000002636PCF11YDR228CverifiedmRNA 3' end processing factor, essential component of cleavageand polyadenylation factor IA (CF IA), involvedin pre-mRNA 3' end processing and intranscription termination; binds C-terminaldomain of largest subunit of RNA pol II(Rpo21p) 0.061260.19641&radic&radic&radic S000002566SAC3YDR159WverifiedNuclear pore-associated protein, forms a complex with Thp1pthat is involved in transcription and in mRNAexport from the nucleus 0.060740.19507&radic&radic&radic&radic&radic&radic S000004045SPT8YLR055CverifiedSubunit of the SAGA transcriptional regulatory complex but notpresent in SAGA-like complex SLIK/SALSA,required for SAGA-mediated inhibition at somepromoters 0.060690.19487&radic&radic&radic&radic&radic S000000939YER137CUncharacterizedHypothetical protein 0.060340.19396 S000004571NUP188YML103CverifiedSubunit of the nuclear pore complex (NPC), involved in thestructural organization of the complex and ofthe nuclear envelope, also involved in nuclearenvelope permeability, interacts with Pom152pand Nic96p 0.06010.19323 S000003073ARC1YGL105WverifiedProtein that binds tRNA and methionyl- and glutamyl-tRNAsynthetases (Mes1p and Gus1p), delivering tRNAto them, stimulating catalysis, and ensuringtheir localization to the cytoplasm; also bindsquadruplex nucleic acids &radic0.058620.18885&radic S000003661GCD14YJL125CverifiedSubunit of tRNA (1-methyladenosine) methyltransferase, withGcd10p, required for the modification of theadenine at position 58 in tRNAs, especiallytRNAi-Met; first identified as a negativeregulator of GCN4 expression &radic0.057270.18476&radic S000000741EDC3YEL015WverifiedNon-essential conserved protein of unknown function, plays arole in mRNA decapping by specificallyaffecting the function of the decapping enzymeDcp1p; localizes to cytoplasmic mRNA processingbodies 0.05710.1842&radic&radic&radic&radic S000000643BUD23YCR047CverifiedProtein involved in bud-site selection; diploid mutants displaya random budding pattern instead of thewild-type bipolar pattern 0.056920.18355&radic&radic S000003067LSG1YGL099WverifiedPutative GTPase involved in 60S ribosomal subunit biogenesis;required for the release of Nmd3p from 60Ssubunits in the cytoplasm 0.056520.18256&radic S000000912KAP123YER110CverifiedKaryopherin beta, mediates nuclear import of ribosomal proteinsprior to assembly into ribosomes and import ofhistones H3 and H4; localizes to the nuclearpore, nucleus, and cytoplasm; exhibits geneticinteractions with RAI1 0.056160.18163&radic&radic S000003351NUP57YGR119CverifiedEssential subunit of the nuclear pore complex (NPC), functionsas the organizing center of an NPC subcomplexcontaining Nsp1p, Nup49p, Nup57p, and Nic96p 0.056150.18161&radic&radic&radic&radic&radic S000003201TAN1YGL232WverifiedPutative tRNA acetyltransferase, RNA-binding protein requiredfor the formation of the modified nucleosideN(4)-acetylcytidine in serine and leucine tRNAsbut not required for the same modification in18S rRNA &radic0.055690.1802&radic&radic&radic&radic S000003394TIF4631YGR162WverifiedTranslation initiation factor eIF4G, subunit of the mRNAcap-binding protein complex (eIF4F) that alsocontains eIF4E (Cdc33p); associates with thepoly(A)-binding protein Pab1p, also interactswith eIF4A (Tif1p); homologous to Tif4632p 0.055550.1797&radic S000003215RAI1YGL246CverifiedNuclear protein that binds to and stabilizes theexoribonuclease Rat1p, required for pre-rRNAprocessing 0.055010.1782&radic&radic&radic&radic&radic&radic S000004216BUR2YLR226WverifiedCyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2pcomprise a CDK-cyclin complex involved intranscriptional regulation through itsphosphorylation of the carboxy-terminal domainof the largest subunit of RNA polymerase II 0.054550.17703&radic&radic&radic&radic&radic&radic S000000175NUP170YBL079WverifiedAbundant subunit of the nuclear pore complex (NPC), requiredfor proper localization of specificnucleoporins within the NPC, involved innuclear envelope permeability and in chromosomesegregation, has similarity to Nup157p 0.053910.17525&radic&radic&radic S000002572TRM82YDR165WverifiedSubunit of a tRNA methyltransferase complex composed of Trm8pand Trm82p that catalyzes 7-methylguanosinemodification of tRNA &radic0.053410.17386&radic&radic&radic&radic&radic&radic&radic S000000017FUN30YAL019WverifiedProtein whose overexpression affects chromosome stability,potential Cdc28p substrate; homolog of Snf2p;the authentic, non-tagged protein is detectedin highly purified mitochondria inhigh-throughput studies 0.053180.17313&radic&radic&radic&radic&radic S000004736POM152YMR129WverifiedNuclear pore membrane glycoprotein; may be involved induplication of nuclear pores and nuclear porecomplexes during S-phase; 0.05280.17206 S000000302MMS4YBR098WverifiedSubunit of the structure-specific Mms4p-Mus81p endonucleasethat cleaves branched DNA; involved inrecombination and DNA repair 0.052590.17133&radic&radic S000004421CRN1YLR429WverifiedCoronin, cortical actin cytoskeletal component that associateswith the Arp2p/Arp3p complex to regulate itsactivity 0.051180.16702 S000000229YBR025CUncharacterizedHypothetical protein 0.051010.16649&radic S000003272KSS1YGR040WverifiedMitogen-activated protein kinase (MAPK) involved in signaltransduction pathways that control filamentousgrowth and pheromone response 0.050650.16556&radic&radic S000002205SIT4YDL047WverifiedType 2A-related serine-threonine phosphatase that functions inthe G1/S transition of the mitotic cycle;cytoplasmic and nuclear protein that modulatesfunctions mediated by Pkc1p including cell walland actin cytoskeleton organization 0.050510.16521&radic&radic S000005006GCD10YNL062CverifiedSubunit of tRNA (1-methyladenosine) methyltransferase withGcd14p, required for the modification of theadenine at position 58 in tRNAs, especiallytRNAi-Met; first identified as a negativeregulator of GCN4 expression &radic0.050510.16521&radic S000005676MRPL23YOR150WverifiedMitochondrial ribosomal protein of the large subunit 0.050080.1639&radic&radic&radic&radic&radic S000002984KAP122YGL016WverifiedKaryopherin beta, responsible for import of the Toa1p-Toa2pcomplex into the nucleus; binds to nucleoporinsNup1p and Nup2p; may play a role in regulationof pleiotropic drug resistance 0.050080.1639&radic&radic&radic&radic&radic&radic&radic S000000214HHT1YBR010WverifiedOne of two identical histone H3 proteins (see also HHT2); corehistone required for chromatin assembly,involved in heterochromatin-mediated telomericand HM silencing; regulated by acetylation,methylation, and mitotic phosphorylation 0.049770.16297&radic S000000184TEL1YBL088CverifiedProtein kinase primarily involved in telomere lengthregulation; contributes to cell cyclecheckpoint control in response to DNA damage;functionally redundant with Mec1p; homolog ofhuman ataxia telangiectasia (ATM) gene 0.04930.16139&radic&radic&radic&radic&radic&radic S000004836UBP8YMR223WverifiedUbiquitin-specific protease that is a component of the SAGA(Spt-Ada-Gcn5-Acetyltransferase) acetylationcomplex; required for SAGA-mediateddeubiquitination of histone H2B 0.04830.15831&radic&radic&radic S000001688LOS1YKL205WverifiedNuclear pore protein involved in nuclear export of pre-tRNA &radic0.048150.15783&radic&radic&radic&radic&radic S000004410CDC73YLR418CverifiedConstituent of Paf1 complex with RNA polymerase II, Paf1p,Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinctfrom Srb-containing Pol II complexes; requiredfor expression of certain genes, modificationof some histones, and telomere maintenance 0.048150.15783&radic&radic&radic&radic&radic&radic&radic S000005335POP2YNR052CverifiedRNase of the DEDD superfamily, subunit of the Ccr4-Not complexthat mediates 3' to 5' mRNA deadenylation 0.047930.15714&radic S000003412RNR4YGR180CverifiedRibonucleotide-diphosphate reductase (RNR), small subunit; theRNR complex catalyzes the rate-limiting step indNTP synthesis and is regulated by DNAreplication and DNA damage checkpoint pathwaysvia localization of the small subunits 0.047620.15608&radic&radic&radic&radic&radic S000004494RAD52YML032CverifiedProtein that stimulates strand exchange by facilitating Rad51pbinding to single-stranded DNA; annealscomplementary single-stranded DNA; involved inthe repair of double-strand breaks in DNAduring vegetative growth and meiosis 0.047270.15485&radic&radic&radic&radic&radic S000005722LIP5YOR196CverifiedProtein involved in biosynthesis of the coenzyme lipoic acid,has similarity to E. coli lipoic acid synthase 0.047110.15434&radic&radic&radic&radic&radic&radic S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling 0.046580.15257&radic&radic&radic&radic&radic&radic&radic&radic S000000213HHF1YBR009CverifiedOne of two identical histone H4 proteins (see also HHF2); corehistone required for chromatin assembly andchromosome function; contributes to telomericsilencing; N-terminal domain involved inmaintaining genomic integrity 0.046580.15257&radic S000002743MSN5YDR335WverifiedKaryopherin involved in nuclear import and export; shown to beresponsible for nuclear import of replicationprotein A and for export of several proteinsincluding Swi6p, Far1p, and Pho4p; cargodissociation involves binding to RanGTP 0.046480.15231&radic&radic&radic&radic S000005968SGF11YPL047WverifiedIntegral subunit of SAGA histone acetyltransferase complex,regulates transcription of a subset ofSAGA-regulated genes, required for the Ubp8passociation with SAGA and for H2Bdeubiquitylation 0.046370.15189&radic&radic&radic&radic&radic&radic&radic S000002243NDE2YDL085WverifiedMitochondrial external NADH dehydrogenase, catalyzes theoxidation of cytosolic NADH; Nde1p and Nde2pare involved in providing the cytosolic NADH tothe mitochondrial respiratory chain 0.046270.15163 S000001454RPR2YIR015WverifiedSubunit of nuclear RNase P, which cleaves tRNA precursors togenerate mature 5' ends; not shared betweenRNase MRP and RNase P, in contrast to all otherRNase P protein subunits &radic0.046180.15138&radic S000004172SWI6YLR182WverifiedTranscription cofactor, forms complexes with DNA-bindingproteins Swi4p and Mbp1p to regulatetranscription at the G1/S transition; involvedin meiotic gene expression; localizationregulated by phosphorylation; potential Cdc28psubstrate 0.045860.1504&radic&radic&radic&radic&radic S000005677RPB2YOR151CverifiedRNA polymerase II second largest subunit B150, part of centralcore; similar to bacterial beta subunit 0.045650.14972&radic&radic&radic&radic&radic&radic&radic&radic S000003175SPT16YGL207WverifiedSubunit of the heterodimeric FACT complex (Spt16p-Pob3p),facilitates RNA Polymerase II transcriptionelongation through nucleosomes by destabilizingand then reassembling nucleosome structure 0.045610.14949&radic&radic&radic&radic S000004363ROM2YLR371WverifiedGDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutationsare synthetically lethal with mutations inrom1, which also encodes a GEP 0.045340.14871&radic&radic&radic&radic&radic S000005651CAT5YOR125CverifiedMitochondrial inner membrane protein directly involved inubiquinone biosynthesis, essential for severalother metabolic pathways including respirationand gluconeogenic gene activation 0.04530.14859&radic&radic&radic&radic&radic&radic S000001252CRG1YHR209WuncharacterizedPutative S-adenosylmethionine-dependent methyltransferase;mediates cantharidin resistance 0.045290.14854&radic&radic&radic&radic S000000128HEK2YBL032WverifiedRNA binding protein with similarity to hnRNP-K that localizesto the cytoplasm and to subtelomeric DNA;required for the proper localization of ASH1mRNA; involved in the regulation of telomereposition effect and telomere length 0.045060.14771&radic&radic&radic S000004493NDC1YML031WverifiedNuclear envelope protein with multiple putative transmembranedomains, required for nuclear pore complexassembly and spindle pole body duplication;required for meiosis II 0.045060.14771 S000003576NUP192YJL039CverifiedEssential structural subunit of the nuclear pore complex (NPC),localizes to the nuclear periphery of nuclearpores, homologous to human p205 0.044920.14739 S000004021YLR031WUncharacterizedHypothetical protein 0.044680.14665 S000002209LHP1YDL051WverifiedRNA binding protein required for maturation of tRNA and snRNAprecursors; acts as a molecular chaperone forRNAs transcribed by polymerase III; homologousto human La (SS-B) autoantigen &radic0.04460.14637&radic S000003518BIO2YGR286CverifiedBiotin synthase, catalyzes the conversion of dethiobiotin tobiotin, which is the last step of the biotinbiosynthesis pathway; complements E. coli bioBmutant 0.044420.14581&radic&radic&radic&radic S000000935GLC7YER133WverifiedCatalytic subunit of type 1 serine/threonine proteinphosphatase, involved in many processesincluding glycogen metabolism, sporulation, andmitosis; interacts with multiple regulatorysubunits; predominantly isolated with Sds22p 0.044360.14567&radic&radic S000003207CSE1YGL238WverifiedNuclear envelope protein that mediates the nuclear export ofimportin alpha (Srp1p), homolog of metazoan CASprotein, required for accurate chromosomesegregation 0.044320.1455&radic&radic&radic&radic S000004096MDN1YLR106CverifiedHuge dynein-related AAA-type ATPase (midasin), forms extendedpre-60S particle with the Rix1 complex(Rix1p-Ipi1p-Ipi3p), may mediate ATP-dependentremodeling of 60S subunits and subsequentexport from nucleoplasm to cytoplasm 0.044160.14509&radic&radic&radic&radic&radic S000005216SEC2YNL272CverifiedGuanyl-nucleotide exchange factor for the small G-proteinSec4p, located on cytoplasmic vesicles;essential for post-Golgi vesicle transport 0.044050.14471&radic&radic&radic&radic&radic&radic S000004105CFT2YLR115WverifiedSubunit of the mRNA cleavage and polyadenlylation factor (CPF);required for pre-mRNA cleavage, polyadenylationand poly(A) site recognition, 43% similaritywith the mammalian CPSF-100 protein. 0.044090.14471&radic&radic&radic&radic&radic S000004849TAF9YMR236WverifiedSubunit (17 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification, similar to histone H3 0.044050.14471&radic&radic&radic&radic&radic&radic S000002831CAD1YDR423CverifiedAP-1-like bZIP transcriptional activator involved in multiplestress responses, iron metabolism, andpleiotropic drug resistance; controls a set ofgenes involved in stabilizing proteins, bindsconsensus sequence TTACTAA; 5' UTR containsuORFs 0.043950.14434&radic&radic&radic&radic&radic S000006090MEX67YPL169CverifiedPoly(A)RNA binding protein involved in nuclear mRNA export,component of the nuclear pore; ortholog ofhuman TAP 0.043880.14403&radic&radic S000004925PSE1YMR308CverifiedKaryopherin/importin that interacts with the nuclear porecomplex; acts as the nuclear import receptorfor specific proteins, including Pdr1p, Yap1p,Ste12p, and Aft1p 0.043880.14403&radic&radic S000001939IRC6YFR043CuncharacterizedHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 0.04350.14299&radic&radic&radic&radic&radic S000005885HAP5YOR358WverifiedSubunit of the heme-activated, glucose-repressed Hap2/3/4/5CCAAT-binding complex, a transcriptionalactivator and global regulator of respiratorygene expression; required for assembly and DNAbinding activity of the complex 0.043260.14172&radic&radic&radic&radic&radic&radic&radic&radic&radic S000004814RAD14YMR201CverifiedProtein that recognizes and binds damaged DNA during nucleotideexcision repair; subunit of Nucleotide ExcisionRepair Factor 1 (NEF1); contains zinc fingermotif; homolog of human XPA protein 0.042880.14074&radic&radic&radic&radic&radic S000003189NIF3YGL221CverifiedProtein of unknown function, similar to Listeria monocytogenesmajor sigma factor (rpoD gene product); theauthentic, non-tagged protein is detected inhighly purified mitochondria in high-throughputstudies 0.042720.14025&radic&radic&radic&radic S000004008POM34YLR018CverifiedIntegral membrane protein of the nuclear pore; has an importantrole in maintaining the architecture of thepore complex 0.042540.13973&radic&radic&radic&radic&radic S000000015PSK1YAL017WverifiedOne of two (see also PSK2) PAS domain containing S/T proteinkinases; coordinately regulates proteinsynthesis and carbohydrate metabolism andstorage in response to a unknown metabolitethat reflects nutritional status 0.042350.13914&radic&radic&radic S000004134ACF2YLR144CverifiedIntracellular beta-1,3-endoglucanase, expression is inducedduring sporulation; may have a role in corticalactin cytoskeleton assembly 0.042330.1391&radic&radic&radic&radic&radic&radic&radic&radic S000002776YPR1YDR368Wverified2-methylbutyraldehyde reductase, may be involved in isoleucinecatabolism 0.042230.13864&radic&radic&radic&radic&radic&radic&radic&radic S000000347SUP45YBR143CverifiedPolypeptide release factor involved in translation termination;mutant form acts as a recessive omnipotentsuppressor 0.042080.1383&radic S000002269RRP42YDL111CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp4p, Rrp41p,Rrp43p and Dis3p 0.042060.13824&radic&radic S000000065RFA1YAR007CverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 0.042050.13822&radic&radic&radic&radic&radic&radic&radic S000003778ESS1YJR017CverifiedPeptidylprolyl-cis/trans-isomerase (PPIase) specific forphosphorylated serine and threonine residuesN-terminal to proline; regulatesphosphorylation of the RNA polymerase II largesubunit (Rpo21p) C-terminal domain 0.041980.138&radic&radic S000001069RPN1YHR027CverifiedNon-ATPase base subunit of the 19S regulatory particle of the26S proteasome; may participate in therecognition of several ligands of theproteasome; contains a leucine-rich repeat(LRR) domain, a site for protein?proteininteractions 0.041680.13712&radic&radic S000005505CTR9YOL145CverifiedComponent of the Paf1p complex, which is a large complex thatbinds to and modulates the activity of RNApolymerase II and is required for expression ofa subset of genes, including cyclin genes;contains TPR repeats 0.041610.13689&radic S000005624NUP1YOR098CverifiedNuclear pore complex (NPC) subunit, involved in proteinimport/export and in export of RNAs, possiblekaryopherin release factor that acceleratesrelease of karyopherin-cargo complexes aftertransport across NPC; potential Cdc28psubstrate 0.041520.13655&radic&radic&radic&radic&radic S000003026RAD6YGL058WverifiedUbiquitin-conjugating enzyme (E2), involved in postreplicationrepair (with Rad18p), sporulation, telomeresilencing, and ubiquitin-mediated N-end ruleprotein degradation (with Ubr1p) 0.041380.13608&radic&radic&radic&radic&radic&radic S000006046KAP120YPL125WverifiedKaryopherin with a role in the assembly or export of 60Sribosomal subunits 0.041380.13608&radic&radic&radic&radic S000004229LIP2YLR239CverifiedLipoyl ligase, involved in the modification of mitochondrialenzymes by the attachment of lipoic acid groups 0.041010.13497&radic&radic&radic&radic&radic S000002533SWF1YDR126WverifiedPalmitoyltransferase that acts on the SNAREs Snc1p, Syn8p,Tlg1p and likely on all SNAREs; member of afamily of putative palmitoyltransferasescontaining an Asp-His-His-Cys-cysteine rich(DHHC-CRD) domain; may have a role in vacuolefusion 0.040990.13485&radic&radic&radic&radic S000000891PTC2YER089CverifiedType 2C protein phosphatase; dephosphorylates Hog1p to limitmaximal osmostress induced kinase activity;dephosphorylates Ire1p to downregulate theunfolded protein response; dephosphorylatesCdc28p; role in DNA checkpoint inactivation 0.040930.13472&radic&radic S000000285SPT7YBR081CverifiedSubunit of the SAGA transcriptional regulatory complex,involved in proper assembly of the complex;also present as a C-terminally truncated formin the SLIK/SALSA transcriptional regulatorycomplex 0.04060.13361&radic S000000564KRR1YCL059CverifiedEssential nucleolar protein required for the synthesis of 18SrRNA and for the assembly of 40S ribosomalsubunit 0.040260.13245&radic&radic&radic&radic&radic S000002583NGG1YDR176WverifiedTranscriptional regulator involved in glucose repression ofGal4p-regulated genes; component oftranscriptional adaptor and histoneacetyltransferase complexes, the ADA complex,the SAGA complex, and the SLIK complex 0.040260.13245&radic&radic&radic&radic&radic&radic S000003188YGL220WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus 0.040120.13204&radic&radic&radic&radic&radic S000004550TUB1YML085CverifiedAlpha-tubulin; associates with beta-tubulin (Tub2p) to formtubulin dimer, which polymerizes to formmicrotubules 0.039850.13121&radic S000002910SAM2YDR502CverifiedS-adenosylmethionine synthetase, catalyzes transfer of theadenosyl group of ATP to the sulfur atom ofmethionine; one of two differentially regulatedisozymes (Sam1p and Sam2p) 0.039750.13092 S000000111ACH1YBL015WverifiedAcetyl-coA hydrolase, primarily localized to mitochondria;required for acetate utilization and fordiploid pseudohyphal growth 0.039640.13049&radic&radic&radic&radic&radic S000005206POL2YNL262WverifiedCatalytic subunit of DNA polymerase epsilon, one of the majorchromosomal DNA replication polymerasescharacterized by processivity and proofreadingexonuclease activity; also involved in DNAsynthesis during DNA repair 0.039570.13028&radic&radic&radic&radic&radic&radic S000005188SUI1YNL244CverifiedTranslation initiation factor eIF1; component of a complexinvolved in recognition of the initiator codon;modulates translation accuracy at theinitiation phase 0.039550.13006 S000003200YGL231CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum 0.03950.13002&radic&radic&radic&radic&radic S000001326YIL064WUncharacterizedPutative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family 0.03940.12966&radic&radic&radic&radic&radic S000006125HRR25YPL204WverifiedProtein kinase involved in regulating diverse events includingvesicular trafficking, gene expression, DNArepair, and chromosome segregation; binds theCTD of RNA pol II; homolog of mammalian caseinkinase 1delta (CK1delta) 0.039370.12957&radic&radic&radic&radic&radic&radic&radic&radic&radic S000000744EAF5YEL018WuncharacterizedEsa1p-associated factor, subunit of the NuA4 acetyltransferasecomplex 0.039130.12874&radic&radic&radic&radic&radic S000004284GSP1YLR293CverifiedGTP binding protein (mammalian Ranp homolog) involved in themaintenance of nuclear organization, RNAprocessing and transport; regulated by Prp20p,Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p andKap95p; yeast Gsp2p homolog 0.0390.12821&radic&radic&radic S000001346SDS3YIL084CverifiedComponent of the Rpd3p/Sin3p deacetylase complex required forits structural integrity and catalyticactivity, involved in transcriptional silencingand required for sporulation; cells defectivein SDS3 display pleiotropic phenotypes 0.038890.12795&radic&radic&radic&radic S000003080TAF6YGL112CverifiedSubunit (60 kDa) of TFIID and SAGA complexes, involved intranscription initiation of RNA polymerase IIand in chromatin modification, similar tohistone H4 0.038840.1277&radic S000001649TPK3YKL166CverifiedSubunit of cAMP-dependent protein kinase, which contains Tpk1p,Tpk2p, Tpk3p, and regulatory subunit Bcy1p;promotes growth in response to nutrients;mediates induction of apoptosis due toactin-mediated hyperactivation of Ras signaling 0.038620.12692&radic&radic&radic&radic&radic&radic S000002232BRE1YDL074CverifiedE3 ubiquitin ligase for Rad6p, required for the ubiquitinationof histone H2B, recruitment of Rad6p topromoter chromatin and subsequent methylationof histone H3 (on L4 and L79), contains RINGfinger domain 0.038270.12587&radic S000002579SUP35YDR172WverifiedTranslation termination factor eRF3; altered proteinconformation creates the [PSI(+)] prion, adominant cytoplasmically inherited proteinaggregate that alters translational fidelityand creates a nonsense suppressor phenotype 0.038210.12569&radic&radic&radic&radic&radic&radic S000002527TRM1YDR120CverifiedtRNA methyltransferase, localizes to both the nucleus andmitochondrion to produce the modified baseN2,N2-dimethylguanosine in tRNAs in bothcompartments &radic0.0380.1249&radic&radic&radic&radic&radic&radic&radic S000002800SPT3YDR392WverifiedSubunit of the SAGA and SAGA-like transcriptional regulatorycomplexes, interacts with Spt15p to activatetranscription of some RNA polymeraseII-dependent genes, also functions to inhibittranscription at some promoters 0.037790.12416&radic&radic&radic&radic&radic&radic&radic S000001249SKN7YHR206WverifiedNuclear response regulator and transcription factor, part of abranched two-component signaling system;required for optimal induction of heat-shockgenes in response to oxidative stress; involvedin osmoregulation 0.037550.12361&radic&radic&radic&radic&radic S000005784HNT3YOR258WverifiedMember of the third branch of the histidine triad (HIT)superfamily of nucleotide-binding proteins;similar to Aprataxin, a Hint related proteinthat is mutated in individuals with ataxia withoculomotor apraxia 0.03750.12348&radic&radic&radic&radic&radic&radic&radic S000005616PTC5YOR090CverifiedMitochondrially localized type 2C protein phosphatase involvedin regulation of pyruvate dehydrogenaseactivity; contains Mg2+/Mn2+-dependent caseinphosphatase activity in vitro 0.037170.12237&radic&radic&radic&radic&radic S000001325YRB2YIL063CverifiedProtein of unknown function involved in nuclear processes ofthe Ran-GTPase cycle; involved in nuclearprotein export; contains Ran Binding Domain andFxFG repeats; interacts with Srm1p, GTP-Gsp1p,Rna1p and Crm1p; is not essential 0.037150.1223&radic&radic&radic&radic&radic S000002814PDR15YDR406WverifiedATP binding cassette (ABC) transporter of the plasma membrane;general stress response factor implicated incellular detoxification; target of Pdr1p, Pdr3pand Pdr8p transcription regulators; promotercontains a PDR responsive element 0.037030.12192&radic&radic S000002744YDR336WUncharacterizedPutative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene 0.036960.12168&radic&radic&radic&radic S000002993PGD1YGL025CverifiedSubunit of the Mediator global transcriptional cofactorcomplex, which is part of the RNA polymerase IIholoenzyme and plays an essential role in basaland activated transcription; direct target ofthe Cyc8p-Tup1p transcriptional corepressor 0.036760.12106&radic&radic&radic&radic&radic S000002789YRA1YDR381WverifiedNuclear protein that binds to RNA and to Mex67p, required forexport of poly(A)+ mRNA from the nucleus;member of the REF (RNA and export factorbinding proteins) family; another familymember, Yra2p, can substitute for Yra1pfunction 0.036460.12021&radic&radic&radic&radic&radic&radic S000005041PHO23YNL097CverifiedProbable component of the Rpd3 histone deacetylase complex,involved in transcriptional regulation of PHO5;C-terminus has similarity to human candidatetumor suppressor p33(ING1) 0.036280.11947&radic S000001149CDC12YHR107CverifiedComponent of the septin ring of the mother-bud neck that isrequired for cytokinesis; septins recruitproteins to the neck and can act as a barrierto diffusion at the membrane, and they comprisethe 10nm filaments seen with EM 0.036160.11923&radic&radic&radic&radic&radic S000004075ARP6YLR085CverifiedActin-related protein that binds nucleosomes; a component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.036050.11889&radic&radic&radic&radic&radic&radic S000000483PAF1YBR279WverifiedRNA polymerase II-associated protein, defines a large complexthat is biochemically and functionally distinctfrom the Srb-Mediator form of Pol II holoenzymeand is required for full expression of a subsetof cell cycle-regulated genes 0.035980.11869&radic S000002774YDR366CUncharacterizedHypothetical protein 0.035920.11845 S000003335NOP7YGR103WverifiedNucleolar protein involved in rRNA processing and 60S ribosomalsubunit biogenesis; constituent of severaldifferent pre-ribosomal particles; required forexit from G0 and the initiation ofcell proliferation 0.035880.11834&radic&radic&radic S000002163MED2YDL005CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation 0.035860.11832&radic S000004876SAP30YMR263WverifiedSubunit of a histone deacetylase complex, along with Rpd3p andSin3p, that is involved in silencing attelomeres, rDNA, and silent mating-type loci;involved in telomere maintenance 0.03580.11809&radic&radic&radic&radic S000000913SWI4YER111CverifiedDNA binding component of the SBF complex (Swi4p-Swi6p), atranscriptional activator that in concert withMBF (Mbp1-Swi6p) regulates late G1-specifictranscription of targets including cyclins andgenes required for DNA synthesis and repair 0.035790.11806&radic&radic S000000851TPA1YER049WuncharacterizedProtein of unknown function; interacts with Sup45p (eRF1),Sup35p (eRF3) and Pab1p; has a role intranslation termination efficiency, mRNApoly(A) tail length and mRNA stability 0.035690.11776&radic&radic&radic&radic&radic&radic&radic S000003506TAF1YGR274CverifiedTFIID subunit (145 kDa), involved in RNA polymerase IItranscription initiation, has histoneacetyltransferase activity, involved inpromoter binding and G1/S progression 0.035610.11746&radic&radic&radic&radic&radic S000001473LYS1YIR034CverifiedSaccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzesthe conversion of saccharopine to L-lysine,which is the final step in the lysinebiosynthesis pathway 0.035550.1173&radic&radic&radic&radic&radic&radic S000000323MUD1YBR119WverifiedU1 snRNP A protein, homolog of human U1-A; involved in nuclearmRNA splicing 0.035540.11713&radic S000006347RRP15YPR143WverifiedNucleolar protein, constituent of pre-60S ribosomal particles;required for processing of the 27S pre-rRNA atthe A2 site to yield 5.8S and 25S rRNA 0.035480.11702&radic&radic S000004762NUP53YMR153WverifiedSubunit of the nuclear pore complex (NPC), interacts withkaryopherin Kap121p or with Nup170p viaoverlapping regions of Nup53p, involved inactivation of the spindle checkpoint mediatedby the Mad1p-Mad2p complex 0.035480.11698&radic&radic&radic&radic&radic S000001596RAD27YKL113Cverified5' to 3' exonuclease, 5' flap endonuclease, required forOkazaki fragment processing and maturation aswell as for long-patch base-excision repair;member of the S. pombe RAD2/FEN1 family 0.035270.11627&radic&radic&radic&radic&radic S000001526PHD1YKL043WverifiedTranscriptional activator that enhances pseudohyphal growth;regulates expression of FLO11, an adhesinrequired for pseudohyphal filament formation;similar to StuA, an A. nidulans developmentalregulator; potential Cdc28p substrate 0.035170.11592&radic&radic&radic&radic&radic&radic&radic S000005769PUS7YOR243CverifiedPseudouridine synthase, catalyzes pseudouridylation at position35 in U2 snRNA, position 13 in cytoplasmictRNAs, and position 35 in pre-tRNA(Tyr);Asp(256) mutation abolishes activity; conservedin archaea, some bacteria, and vertebrates &radic0.035170.11579&radic&radic&radic&radic&radic&radic S000000907NUP157YER105CverifiedAbundant subunit of the nuclear pore complex (NPC), present onboth sides of the NPC, has similarity toNup170p 0.03510.11547 S000001083SRB2YHR041CverifiedGeneral transcription factor, subunit of the RNA polymerase IImediator complex; associates with corepolymerase subunits to form the RNA polymeraseII holoenzyme; involved in telomere maintenance 0.035010.11537&radic&radic S000002803SXM1YDR395WverifiedNuclear transport factor (karyopherin) involved in proteintransport between the cytoplasm andnucleoplasm; similar to Nmd5p, Cse1p, Lph2p,and the human cellular apoptosis susceptibilityprotein, CAS1 0.034990.1152&radic&radic&radic&radic&radic S000004663SEN15YMR059WverifiedSubunit of the tRNA splicing endonuclease, which is composed ofSen2p, Sen15p, Sen34p, and Sen54p &radic0.034920.11508 S000001725YKR017CUncharacterizedPutative protein of unknown function; contains a RING finger motif 0.034880.11496&radic&radic&radic&radic S000000322TEF2YBR118WverifiedTranslational elongation factor EF-1 alpha; also encoded byTEF1; functions in the binding reaction ofaminoacyl-tRNA (AA-tRNA) to ribosomes 0.03480.11465&radic S000004738RRB1YMR131CverifiedEssential nuclear protein involved in early steps of ribosomebiogenesis; physically interacts with theribosomal protein Rpl3p 0.034740.11447&radic S000006382PRP4YPR178WverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.034720.11437&radic&radic&radic&radic&radic&radic S000003484GCN5YGR252WverifiedHistone acetyltransferase, acetylates N-terminal lysines onhistones H2B and H3; catalytic subunit of theADA and SAGA histone acetyltransferasecomplexes; founding member of the Gcn5p-relatedN-acetyltransferase superfamily 0.034690.11423&radic S000002764SPC110YDR356WverifiedInner plaque spindle pole body (SPB) component, ortholog ofhuman kendrin; involved in connecting nuclearmicrotubules to SPB; interacts withTub4p-complex and calmodulin; phosphorylated byMps1p in cell cycle-dependent manner 0.034570.11386&radic&radic&radic&radic S000004470SPT5YML010WverifiedProtein that forms a complex with Spt4p and mediates bothactivation and inhibition of transcriptionelongation; Spt4p-Spt5p complex also plays arole in pre-mRNA processing 0.034550.11376&radic&radic&radic&radic&radic&radic&radic S000001756NAP1YKR048CverifiedProtein that interacts with mitotic cyclin Clb2p; required forthe regulation of microtubule dynamics duringmitosis; controls bud morphogenesis; involvedin the transport of H2A and H2B histones to thenucleus 0.034480.11357&radic&radic&radic&radic&radic S000003054MAD1YGL086WverifiedCoiled-coil protein involved in the spindle-assemblycheckpoint; phosphorylated by Mps1p uponcheckpoint activation which leads to inhibitionof the activity of the anaphase promotingcomplex; forms a complex with Mad2p 0.034460.11343 S000000329PTC4YBR125CverifiedCytoplasmic type 2C protein phosphatase; identified as ahigh-copy number suppressor of the syntheticlethality of a cnb1 mpk1 double deletion;overexpression decreases high-osmolarityinduced Hog1p phosphorylation and kinaseactivity 0.034280.11274&radic S000005294PRP2YNR011CverifiedRNA-dependent ATPase in the DEAH-box family, required foractivation of the spliceosome before the firsttransesterification step in RNA splicing 0.034290.11274&radic&radic S000001028MUP3YHL036WverifiedLow affinity methionine permease, similar to Mup1p 0.034030.11193&radic&radic S000005261PFS2YNL317WverifiedIntegral subunit of the pre-mRNA cleavage and polyadenylationfactor (CPF) complex; plays an essential rolein mRNA 3'-end formation by bridging differentprocessing factors and thereby promoting theassembly of the processing complex 0.033910.11161&radic&radic&radic&radic&radic S000004198SEC13YLR208WverifiedComponent of both the Nup84 nuclear pore sub-complex and of theCOPII complex (Sar1p, Sec13p, Sec16p, Sec23p,Sec24p, Sec31p, Sfb2p, and Sfb3p) which isimportant for the formation of ER to Golgitransport vesicles 0.033790.11115&radic&radic&radic S000001505CDC16YKL022CverifiedSubunit of the anaphase-promoting complex/cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition; required forsporulation 0.033640.11066&radic&radic&radic&radic&radic S000000379SWD3YBR175WverifiedEssential subunit of the COMPASS (Set1C) complex, whichmethylates histone H3 on lysine 4 and isrequired in transcriptional silencing neartelomeres; WD40 beta propeller superfamilymember and ortholog of mammalian WDR5 0.033630.11063&radic&radic&radic&radic&radic&radic S000002571SEC1YDR164CverifiedSm-like protein involved in docking and fusion of exocyticvesicles through binding to assembled SNAREcomplexes at the membrane; localization tosites of secretion (bud neck and bud tip) isdependent on SNARE function 0.033520.1102&radic&radic&radic&radic S000004138PEP3YLR148WverifiedVacuolar peripheral membrane protein that promotes vesiculardocking/fusion reactions in conjunction withSNARE proteins, required for vacuolarbiogenesis, forms complex with Pep5p thatmediates protein transport to the vacuole 0.033520.1102&radic&radic&radic&radic&radic&radic S000006074RAD53YPL153CverifiedProtein kinase, required for cell-cycle arrest in response toDNA damage; activated by transautophosphorylation when interacting withhyperphosphorylated Rad9p; also interacts withARS1 and plays a role in initiation of DNAreplication 0.03320.10915&radic&radic&radic&radic S000005815YOR289WUncharacterizedHypothetical protein 0.03320.10915&radic&radic&radic&radic&radic&radic&radic&radic S000005724BFR1YOR198CverifiedComponent of mRNP complexes associated with polyribosomes;implicated in secretion and nuclearsegregation; multicopy suppressor of BFA(Brefeldin A) sensitivity 0.033190.10915&radic&radic&radic&radic&radic S000002447ENA1YDR040CverifiedP-type ATPase sodium pump, involved in Na+ and Li+ efflux toallow salt tolerance 0.033140.10901 S000001608RRN3YKL125WverifiedProtein required for transcription of rDNA by RNA polymerase I;transcription factor independent of DNAtemplate; involved in recruitment of RNApolymerase I to rDNA 0.033130.10894&radic&radic&radic S000003213RTF1YGL244WverifiedSubunit of the RNA polymerase II-associated Paf1 complex;directly or indirectly regulates DNA-bindingproperties of Spt15p and relative activities ofdifferent TATA elements; involved in telomeremaintenance 0.033110.10891&radic&radic&radic&radic S000000340MEC1YBR136WverifiedGenome integrity checkpoint protein and PI kinase superfamilymember; signal transducer required for cellcycle arrest and transcriptional responsesprompted by damaged or unreplicated DNA;monitors and participates in meioticrecombination 0.033040.10868 S000002918SMT3YDR510WverifiedUbiquitin-like protein of the SUMO family, conjugated to lysineresidues of target proteins; regulateschromatid cohesion, chromosome segregation,APC-mediated proteolysis, DNA replication andseptin ring dynamics 0.0330.10853&radic&radic S000005364SIN3YOL004WverifiedComponent of the Sin3p-Rpd3p histone deacetylase complex,involved in transcriptional repression andactivation of diverse processes, includingmating-type switching and meiosis; involved inthe maintenance of chromosomal integrity 0.033020.10853&radic&radic&radic&radic&radic S000005976LGE1YPL055CverifiedProtein of unknown function; null mutant forms abnormally largecells 0.032970.10847&radic&radic&radic&radic&radic&radic&radic S000002284CDC48YDL126CverifiedATPase in ER, nuclear membrane and cytosol with homology tomammalian p97; in a complex with Npl4p andUfd1p participates in retrotranslocation ofubiquitinated proteins from the ER into thecytosol for degradation by the proteasome 0.032890.10821&radic&radic S000004389AFG2YLR397CverifiedATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexamericcomplex; may be involved in degradation ofaberrant mRNAs 0.032850.10808&radic&radic&radic&radic&radic S000005383IFM1YOL023WverifiedMitochondrial translation initiation factor 2 0.032820.10805&radic&radic&radic&radic S000000064SWD1YAR003WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres; WD40beta propeller superfamily member withsimilarity to mammalian Rbbp7 0.032770.10784&radic&radic&radic&radic&radic&radic S000000818BIM1YER016WverifiedMicrotubule-binding protein that together with Kar9p makes upthe cortical microtubule capture site anddelays the exit from mitosis when the spindleis oriented abnormally 0.032650.10743&radic&radic&radic&radic S000006130IPL1YPL209CverifiedAurora kinase involved in regulating kinetochore-microtubuleattachments; helps maintain condensedchromosomes during anaphase and earlytelophase; associates with Sli15p, whichpromotes Ipl1p association with mitotic spindle 0.032570.10714&radic&radic&radic S000001049ERG11YHR007CverifiedLanosterol 14-alpha-demethylase, catalyzes the C-14demethylation of lanosterol to form4,4''-dimethylcholesta-8,14,24-triene-3-beta-ol in theergosterol biosynthesis pathway; member of thecytochrome P450 family 0.032560.10714&radic&radic&radic&radic S000004378VAC14YLR386WverifiedProtein involved in regulated synthesis of PtdIns(3,5)P(2), incontrol of trafficking of some proteins to thevacuole lumen via the MVB, and in maintenanceof vacuole size and acidity; activator of Fab1p 0.032330.10641&radic&radic&radic S000003068SEH1YGL100WverifiedNuclear pore protein that is part of the evolutionarilyconserved Nup84p complex (Nup84p, Nup85p,Nup120p, Nup145p, and Seh1p); homologous toSec13p 0.032320.10631 S000005440REX4YOL080CverifiedPutative RNA exonuclease possibly involved in pre-rRNAprocessing and ribosome assembly 0.032180.1058&radic&radic&radic S000003461SMI1YGR229CverifiedProtein involved in the regulation of cell wall synthesis;proposed to be involved in coordinating cellcycle progression with cell wall integrity 0.032070.1056&radic&radic&radic&radic&radic&radic&radic S000005537AUS1YOR011WverifiedTransporter of the ATP-binding cassette family, involved inuptake of sterols and anaerobic growth 0.031990.10535&radic&radic&radic&radic S000005572DBP5YOR046CverifiedCytoplasmic ATP-dependent RNA helicase of the DEAD-box familyinvolved in mRNA export from the nucleus 0.031950.10523&radic&radic&radic&radic S000005732NOC2YOR206WverifiedProtein that forms a nucleolar complex with Mak21p that bindsto 90S and 66S pre-ribosomes, as well as anuclear complex with Noc3p that binds to 66Spre-ribosomes; both complexes mediateintranuclear transport of ribosomal precursors 0.03190.10507&radic&radic&radic&radic&radic S000003676RPB4YJL140WverifiedRNA polymerase II subunit B32; forms two subunit dissociablecomplex with Rpb7p; dispensable under someenvironmental conditions; involved in export ofmRNA to cytoplasm under stress conditions;involved in telomere maintenance 0.031830.10487&radic S000003140NUP49YGL172WverifiedSubunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of thenuclear pore complex (NPC), required fornuclear export of ribosomes &radic0.031790.10479 S000004976HHT2YNL031CverifiedOne of two identical histone H3 proteins (see also HHT1); corehistone required for chromatin assembly,involved in heterochromatin-mediated telomericand HM silencing; regulated by acetylation,methylation, and mitotic phosphorylation 0.031750.10464 S000003245SNU71YGR013WverifiedComponent of U1 snRNP required for mRNA splicing viaspliceosome; yeast specific, no metazoancounterpart 0.031730.1046&radic&radic&radic&radic&radic S000002264PHO2YDL106CverifiedHomeobox transcription factor; regulatory targets include genesinvolved in phosphate metabolism; bindscooperatively with Pho4p to the PHO5 promoter;phosphorylation of Pho2p facilitatesinteraction with Pho4p 0.031530.10393&radic S000003664PBS2YJL128CverifiedMAP kinase kinase that plays a pivotal role in the osmosensingsignal-transduction pathway, activated undersevere osmotic stress 0.031540.10393&radic S000003853FIP1YJR093CverifiedSubunit of cleavage polyadenylation factor (CPF), interactsdirectly with poly(A) polymerase (Pap1p) toregulate its activity 0.031540.10393 S000000633PHO87YCR037CverifiedLow-affinity inorganic phosphate (Pi) transporter, involved inactivation of PHO pathway; expression isindependent of Pi concentration and Pho4pactivity; contains 12 membrane-spanningsegments 0.031290.10315 S000005783CDC31YOR257WverifiedComponent of the spindle pole body (SPB) half-bridge, requiredfor SPB duplication in mitosis and meiosis II;homolog of mammalian centrin; interacts withKar1p 0.031210.1029&radic&radic&radic S000004642SUB1YMR039CverifiedTranscriptional coactivator, facilitates elongation byinfluencing enzymes that modify RNAP II, actsin a peroxide resistance pathway involvingRad2p; suppressor of TFIIB mutations 0.031060.10237&radic&radic&radic&radic&radic S000000313CMD1YBR109CverifiedCalmodulin; Ca++ binding protein that regulates Ca++independent processes (mitosis, bud growth,actin organization, endocytosis, etc.) and Ca++dependent processes (stress-activatedpathways), targets include Nuf1p, Myo2p andcalcineurin 0.031060.10237 S000005411GAL11YOL051WverifiedComponent of the Mediator complex; interacts with RNApolymerase II and the general transcriptionfactors to form the RNA polymerase IIholoenzyme; affects transcription by acting astarget of activators and repressors 0.031060.10237&radic&radic&radic&radic&radic&radic S000004064BUD20YLR074CverifiedProtein involved in bud-site selection; diploid mutants displaya random budding pattern instead of thewild-type bipolar pattern 0.030840.10158&radic&radic&radic&radic&radic S000005354YNR071CUncharacterizedHypothetical protein 0.030750.10124 S000000058GDH3YAL062WverifiedNADP(+)-dependent glutamate dehydrogenase, synthesizesglutamate from ammonia and alpha-ketoglutarate;rate of alpha-ketoglutarate utilization differsfrom Gdh1p; expression regulated by nitrogenand carbon sources 0.030680.10103&radic&radic&radic&radic S000001123LRP1YHR081WverifiedSubstrate-specific nuclear cofactor for exosome activity in theprocessing of stable RNAs; required fortelomere length maintenance; homolog ofmammalian nuclear matrix protein C1D involvedin regulation of DNA repair and recombination 0.030650.10091&radic&radic&radic&radic S000004975HHF2YNL030WverifiedOne of two identical histone H4 proteins (see also HHF1); corehistone required for chromatin assembly andchromosome function; contributes to telomericsilencing; N-terminal domain involved inmaintaining genomic integrity 0.030570.10065&radic S000005046POL1YNL102WverifiedCatalytic subunit of the DNA polymerase alpha-primase complex,required for the initiation of DNA replicationduring mitotic DNA synthesis and premeiotic DNAsynthesis 0.03050.10037&radic&radic&radic&radic&radic S000000259PRP6YBR055CverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.030480.10029&radic&radic S000001308MET30YIL046WverifiedF-box protein containing five copies of the WD40 motif,controls cell cycle function, sulfurmetabolism, and methionine biosynthesis as partof the ubiquitin ligase complex; interacts withand regulates Met4p, localizes within thenucleus 0.030420.10016&radic&radic&radic&radic&radic&radic&radic S000004190YKE2YLR200WverifiedSubunit of the heterohexameric Gim/prefoldin protein complexinvolved in the folding of alpha-tubulin,beta-tubulin, and actin 0.030380.10002&radic&radic&radic&radic S000005705SYC1YOR179CverifiedSubunit of the APT subcomplex of cleavage and polyadenylationfactor, may have a role in 3' end formation ofboth polyadenylated and non-polyadenylated RNAs 0.030330.09982&radic&radic&radic&radic&radic&radic S000002793EFT2YDR385WverifiedElongation factor 2 (EF-2), also encoded by EFT1; catalyzesribosomal translocation during proteinsynthesis; contains diphthamide, the uniqueposttranslationally modified histidine residuespecifically ADP-ribosylated by diphtheriatoxin 0.030150.09921&radic&radic&radic&radic S000003199YGL230CUncharacterizedHypothetical protein 0.030070.09898&radic&radic&radic S000005256RFA2YNL312WverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 0.030010.09874&radic&radic&radic&radic S000003180VAM7YGL212WverifiedComponent of the vacuole SNARE complex involved in vacuolarmorphogenesis; SNAP-25 homolog; functions witha syntaxin homolog Vam3p in vacuolar proteintrafficking 0.029990.09859&radic&radic&radic&radic&radic S000004103HOG1YLR113WverifiedMitogen-activated protein kinase involved in osmoregulation viathree independent osmosensors; mediates therecruitment and activation of RNA Pol II atHot1p-dependent promoters; localizationregulated by Ptp2p and Ptp3p 0.029910.09828&radic&radic&radic&radic&radic&radic S000004135RMP1YLR145WverifiedEssential component of RNase MRP, which processes pre-rRNA inthe nucleolus and also processes mitochondrialRNAs to create RNA primers for DNA replication &radic0.029880.09822&radic&radic&radic&radic&radic S000002709CFT1YDR301WverifiedRNA-binding subunit of the mRNA cleavage and polyadenylationfactor; involved in poly(A) site recognitionand required for both pre-mRNA cleavage andpolyadenylation, 51% sequence similarity withmammalian AAUAA-binding subunit of CPSF 0.029830.09792&radic&radic&radic&radic&radic&radic&radic S000002740IRC3YDR332WuncharacterizedHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 0.029780.09785&radic&radic&radic&radic&radic S000005622RPS7AYOR096WverifiedProtein component of the small (40S) ribosomal subunit, nearlyidentical to Rps7Bp; interacts with Kti11p;deletion causes hypersensitivity to zymocin;has similarity to rat S7 and Xenopus S8ribosomal proteins 0.029750.09773 S000004560RAD10YML095CverifiedSingle-stranded DNA endonuclease (with Rad1p), cleavessingle-stranded DNA during nucleotide excisionrepair and double-strand break repair; subunitof Nucleotide Excision Repair Factor 1 (NEF1);homolog of human ERCC1 protein 0.029690.09753&radic&radic S000004219CDC42YLR229CverifiedSmall rho-like GTPase, essential for establishment andmaintenance of cell polarity; mutants havedefects in the organization of actin andseptins 0.029720.09753 S000005853MYO2YOR326WverifiedOne of two type V myosin motors (along with MYO4) involved inactin-based transport of cargos; required forthe polarized delivery of secretory vesicles,the vacuole, late Golgi elements, peroxisomes,and the mitotic spindle 0.029680.09749&radic&radic&radic&radic&radic&radic S000004068BOS1YLR078Cverifiedv-SNARE (vesicle specific SNAP receptor), localized to theendoplasmic reticulum membrane and necessaryfor vesicular transport from the ER to theGolgi 0.029630.09731&radic&radic&radic&radic&radic&radic S000002198NAT1YDL040CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.029480.09675&radic S000005499CDC33YOL139CverifiedCytoplasmic mRNA cap binding protein; the eIF4E-cap complex isresponsible for mediating cap-dependent mRNAtranslation via interactions with thetranslation initiation factor eIF4G (Tif4631por Tif4632p) 0.029410.09629&radic S000004651CSM3YMR048WverifiedProtein required for accurate chromosome segregation duringmeiosis 0.029250.09588&radic S000005274RPD3YNL330CverifiedHistone deacetylase; regulates transcription and silencing 0.029190.09578&radic&radic&radic&radic&radic&radic&radic S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.029080.09542&radic&radic&radic&radic&radic&radic&radic&radic S000005079FPR1YNL135CverifiedPeptidyl-prolyl cis-trans isomerase (PPIase), binds to thedrugs FK506 and rapamycin; also binds to thenonhistone chromatin binding protein Hmo1p andmay regulate its assembly or function 0.029070.09535&radic&radic S000001365DPH1YIL103WverifiedProtein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p,for synthesis of diphthamide, which is amodified histidine residue of translationelongation factor 2 (Eft1p or Eft2p); may actin a complex with Dph2p and Kti11p 0.029030.09516&radic S000000885GET2YER083CverifiedSubunit of the GET complex; required for meiotic nucleardivision and for the retrieval of HDEL proteinsfrom the Golgi to the ER in an ERD2 dependentfashion; may be involved in cell wall function 0.029020.09516&radic&radic&radic&radic&radic S000003783LSM8YJR022WverifiedLsm (Like Sm) protein; forms heteroheptameric complex (withLsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p)that is part of spliceosomal U6 snRNP and isalso implicated in processing of pre-tRNA,pre-snoRNA, and pre-rRNA 0.029020.09516&radic&radic S000005056DBP2YNL112WverifiedEssential ATP-dependent RNA helicase of the DEAD-box proteinfamily, involved in nonsense-mediated mRNAdecay and rRNA processing 0.029010.09513&radic&radic S000000967PAB1YER165WverifiedPoly(A) binding protein, part of the 3'-end RNA-processingcomplex, mediates interactions between the 5'cap structure and the 3' mRNA poly(A) tail,involved in control of poly(A) tail length,interacts with translation factor eIF-4G 0.028990.09509&radic S000001094CIC1YHR052WverifiedEssential protein that interacts with proteasome components andhas a potential role in proteasome substratespecificity; also copurifies with 66Spre-ribosomal particles 0.028990.09507&radic S000004267YSH1YLR277CverifiedPutative endonuclease, subunit of the mRNA cleavage andpolyadenylation specificity complex requiredfor 3' processing of mRNAs 0.028890.09459&radic&radic&radic&radic&radic S000000421ATG12YBR217WverifiedUbiquitin-like modifier, conjugated via an isopeptide bond to alysine residue of Atg5p by the E1 enzyme,Atg7p, and the E2 enzyme, Atg10p, a step thatis essential for autophagy 0.028860.09459&radic&radic&radic&radic&radic S000000152PTC3YBL056WverifiedType 2C protein phosphatase; dephosphorylates Hog1p (see alsoPtc2p) to limit maximal kinase activity inducedby osmotic stress; dephosphorylates T169phosphorylated Cdc28p (see also Ptc2p); role inDNA checkpoint inactivation 0.028750.09418&radic&radic&radic&radic&radic S000001504MAK11YKL021CverifiedProtein essential for cell growth and replication of M dsRNAvirus; contains four beta-transducin repeats 0.028690.0939&radic&radic&radic&radic&radic S000004852RNT1YMR239CverifiedRNAase III; cleaves a stem-loop structure at the 3' end of U2snRNA to ensure formation of the correct U2 3'end 0.02870.0939&radic&radic&radic&radic&radic&radic S000006128TYW1YPL207WuncharacterizedHypothetical protein 0.028590.09357&radic&radic&radic&radic&radic S000006214RPA135YPR010CverifiedRNA polymerase I subunit A135 0.028590.09355 S000004368PSY3YLR376CuncharacterizedProtein of unknown function; deletion results in a mutatorphenotype suggesting a role for this protein asa mutational suppressor; deletion increasessensitivity to anticancer drugs oxaliplatin andcisplatin but not mitomycin C 0.028440.09297&radic&radic&radic&radic&radic&radic S000000667IMG2YCR071CverifiedMitochondrial ribosomal protein of the small subunit 0.028420.09294 S000005171JJJ1YNL227CverifiedProtein that contains a 70 amino acid J-domain, may function asa co-chaperone to recruit Hsp70-like activityto specific sites; mutation causes defects influid-phase endocytosis 0.028420.09294&radic&radic&radic S000005215BNI1YNL271CverifiedFormin, nucleates the formation of linear actin filaments,involved in cell processes such as budding andmitotic spindle orientation which require theformation of polarized actin cables,functionally redundant with BNR1 0.028390.09271&radic&radic&radic&radic&radic&radic&radic S000004890FCP1YMR277WverifiedCarboxy-terminal domain (CTD) phosphatase, essential fordephosphorylation of the repeated C-terminaldomain of the RNA polymerase II large subunit(Rpo21p) 0.028350.09264&radic&radic&radic&radic&radic&radic S000005483HRP1YOL123WverifiedSubunit of cleavage factor I, a five-subunit complex requiredfor the cleavage and polyadenylation ofpre-mRNA 3' ends; RRM-containing heteronuclearRNA binding protein and hnRNPA/B family memberthat binds to poly (A) signal sequences 0.028340.09264&radic S000002835RPN9YDR427WverifiedNon-ATPase regulatory subunit of the 26S proteasome, hassimilarity to putative proteasomal subunits inother species; null mutant is temperaturesensitive and exhibits cell cycle andproteasome assembly defects 0.028230.0922&radic S000001734GCN3YKR026CverifiedAlpha subunit of the translation initiation factor eIF2B, theguanine-nucleotide exchange factor for eIF2;activity subsequently regulated byphosphorylated eIF2; first identified as apositive regulator of GCN4 expression 0.028130.09179&radic&radic&radic&radic&radic&radic&radic S000006373JIP5YPR169WuncharacterizedNucleolar protein of unknown function, exhibits a physicalinteraction with Bre1p 0.028110.09166&radic S000001051YHR009CUncharacterizedPutative protein of unknown function; not an essential gene 0.027940.09116&radic&radic S000000100UTP20YBL004WverifiedComponent of the small-subunit (SSU) processome, which isinvolved in the biogenesis of the 18S rRNA 0.027960.09116&radic&radic&radic&radic&radic S000005166SSU72YNL222WverifiedTranscription/RNA-processing factor that associates with TFIIBand cleavage/polyadenylation factor Pta1p;exhibits phosphatase activity on serine-5 ofthe RNA polymerase II C-terminal domain;affects start site selection in vivo 0.027910.09107&radic&radic&radic&radic&radic S000001111RRP4YHR069CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp41p, Rrp42p,Rrp43p and Dis3p 0.027870.09089&radic&radic&radic&radic&radic S000003093MET13YGL125WverifiedIsozyme of methylenetetrahydrofolate reductase, catalyzes thereduction of 5,10-methylenetetrahydrofolate to5-methyltetrahydrofolate in the methioninebiosynthesis pathway 0.02780.09061&radic&radic S000005366TOP1YOL006CverifiedTopoisomerase I, nuclear enzyme that relieves torsional strainin DNA by cleaving and re-sealing thephosphodiester backbone; relaxes bothpositively and negatively supercoiled DNA;functions in replication, transcription, andrecombination 0.027760.09042&radic&radic&radic&radic&radic&radic S000001411MLP2YIL149CverifiedMyosin-like protein associated with the nuclear envelope,connects the nuclear pore complex with thenuclear interior; involved in the Tel1p pathwaythat controls telomere length 0.027620.08987 S000003212TAD1YGL243WverifiedtRNA-specific adenosine deaminase, deaminates adenosine-37 toinosine in tRNA-Ala &radic0.027560.08972&radic&radic&radic&radic S000000099HTA2YBL003CverifiedOne of two nearly identical (see also HTA1) histone H2Asubtypes; core histone required for chromatinassembly and chromosome function; DNAdamage-dependent phosphorylation by Mec1pfacilitates DNA repair; acetylated by Nat4p 0.027560.08972&radic&radic&radic&radic&radic&radic S000002247YDL089WUncharacterizedProtein of unknown function; interacts with meiotic division protein Csm1p; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery, potential Cdc28p substrate 0.027550.08965 S000000264ORC2YBR060CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing; may be phosphorylated by Cdc28p 0.027520.08961&radic&radic S000000011DEP1YAL013WverifiedTranscriptional modulator involved in regulation of structuralphospholipid biosynthesis genes andmetabolically unrelated genes, as well asmaintenance of telomeres, mating efficiency,and sporulation 0.027440.08933&radic&radic&radic&radic&radic S000005882GDS1YOR355WverifiedProtein of unknown function, required for growth on glycerol asa carbon source; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.027320.08875&radic&radic&radic&radic&radic S000000631RRP43YCR035CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp41p, Rrp42p,Rrp4p and Dis3p; required for efficientmaturation of 5.8S, 18S and 25S rRNA 0.027220.0884&radic S000002323CDC9YDL164CverifiedDNA ligase found in the nucleus and mitochondria, an essentialenzyme that joins Okazaki fragments during DNAreplication; also acts in nucleotide excisionrepair, base excision repair, and recombination 0.027210.0884&radic S000006314RPC40YPR110CverifiedRNA polymerase subunit, common to RNA polymerase I and III 0.027130.08808&radic&radic&radic&radic S000006339CTF4YPR135WverifiedChromatin-associated protein, required for sister chromatidcohesion; interacts with DNA polymerase alpha(Pol1p) and may link DNA synthesis to sisterchromatid cohesion 0.027140.08808&radic&radic&radic&radic&radic S000000201PKC1YBL105CverifiedProtein serine/threonine kinase essential for cell wallremodeling during growth; localized to sites ofpolarized growth and the mother-daughter budneck; homolog of the alpha, beta, and gammaisoforms of mammalian protein kinase C (PKC) 0.027030.08766&radic S000006002RPS9AYPL081WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps9Bp and has similarity to E.coli S4 and rat S9 ribosomal proteins 0.026930.0873&radic&radic&radic&radic&radic S000001728VPS51YKR020WverifiedComponent of the GARP (Golgi-associated retrograde protein)complex, Vps51p-Vps52p-Vps53p-Vps54p, which isrequired for the recycling of proteins fromendosomes to the late Golgi; links the(VFT/GARP) complex to the SNARE Tlg1p 0.026870.0871&radic&radic&radic&radic S000002994TRP5YGL026CverifiedTryptophan synthase involved in tryptophan biosynthesis,regulated by the general control system ofamino acid biosynthesis 0.026860.08702&radic&radic S000001674DPH2YKL191WverifiedProtein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p,for synthesis of diphthamide, which is amodified histidine residue of translationelongation factor 2 (Eft1p or Eft2p); may actin a complex with Dph1p and Kti11p 0.02680.08685&radic&radic&radic&radic&radic&radic S000004903HAS1YMR290CverifiedATP-dependent RNA helicase; localizes to both the nuclearperiphery and nucleolus; highly enriched innuclear pore complex fractions; constituent of66S pre-ribosomal particles 0.026790.08681&radic&radic&radic S000005454RFC4YOL094CverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon 0.026720.08659&radic S000000307SIF2YBR103WverifiedWD40 repeat-containing subunit of the Set3C histone deacetylasecomplex, which represses early/middlesporulation genes; antagonizes telomericsilencing; binds specifically to the Sir4pN-terminus 0.026690.08648&radic S000003490RAD2YGR258CverifiedSingle-stranded DNA endonuclease, cleaves single-stranded DNAduring nucleotide excision repair to excisedamaged DNA; subunit of Nucleotide ExcisionRepair Factor 3 (NEF3); homolog of human XPGprotein 0.026550.08582&radic&radic S000004673NAT4YMR069WverifiedN alpha-acetyl-transferase, involved in acetylation of theN-terminal residues of histones H4 and H2A 0.026560.08582&radic&radic S000000883SER3YER081Wverified3-phosphoglycerate dehydrogenase, catalyzes the first step inserine and glycine biosynthesis; isozyme ofSer33p 0.026570.08582&radic&radic&radic&radic&radic&radic&radic S000005606DIA2YOR080WverifiedOrigin-binding F-box protein that forms an SCF ubiquitin ligasecomplex with Skp1p and Cdc53p; plays a role inDNA replication, involved in invasive andpseudohyphal growth 0.026570.08582&radic&radic&radic&radic&radic S000004520IMD4YML056CverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 0.02660.08582&radic S000002773ESF1YDR365CverifiedNucleolar protein involved in pre-rRNA processing; depletioncauses severely decreased 18S rRNA levels 0.026520.08577&radic&radic&radic&radic&radic S000001207DNA2YHR164CverifiedEssential tripartite DNA replication factor withsingle-stranded DNA-dependent ATPase,ATP-dependent nuclease, and helicaseactivities; required for Okazaki fragmentprocessing; involved in DNA repair pathways;potential Cdc28p substrate 0.026510.08577&radic&radic&radic&radic&radic S000000360SLI15YBR156CverifiedSubunit of the Ipl1p-Sli15p-Bir1p complex that regulateskinetochore-microtubule attachments, activationof the spindle tension checkpoint, and mitoticspindle disassembly; regulates the activity andlocalization of the Ipl1p aurora kinase 0.02650.08566&radic S000001057MIP6YHR015WverifiedPutative RNA-binding protein, interacts with Mex67p, which is acomponent of the nuclear pore involved innuclear mRNA export 0.026470.08546&radic&radic&radic&radic&radic S000000897RAD51YER095WverifiedStrand exchange protein, forms a helical filament with DNA thatsearches for homology; involved in therecombinational repair of double-strand breaksin DNA during vegetative growth and meiosis;homolog of Dmc1p and bacterial RecA protein 0.026470.08546&radic&radic S000006345KAR3YPR141CverifiedMinus-end-directed microtubule motor that functions in mitosisand meiosis, localizes to the spindle pole bodyand localization is dependent on functionalCik1p, required for nuclear fusion duringmating; potential Cdc28p substrate 0.026420.08537&radic&radic&radic&radic&radic&radic S000000450YBR246WUncharacterizedHypothetical protein 0.026360.08511&radic&radic&radic&radic&radic S000004683CTF18YMR078CverifiedSubunit of a complex with Ctf8p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion; may have overlappingfunctions with Rad24p in the DNA damagereplication checkpoint 0.02630.08489&radic&radic S000004012SDO1YLR022CuncharacterizedEssential protein involved in RNA metabolism, one of two yeasthomologs (with Yhr087wp) of the human proteinSBDS responsible for autosomal recessiveShwachman-Bodian-Diamond Syndrome, alsoconserved in Archaea 0.026280.08478&radic&radic&radic&radic&radic S000006284TEF1YPR080WverifiedTranslational elongation factor EF-1 alpha; also encoded byTEF2; functions in the binding reaction ofaminoacyl-tRNA (AA-tRNA) to ribosomes 0.026220.08457&radic S000005730DED1YOR204WverifiedATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, requiredfor translation initiation of all yeast mRNAs;mutations in human DEAD-box DBY are a frequentcause of male infertility 0.026160.08437&radic&radic&radic&radic S000001807BAS1YKR099WverifiedMyb-related transcription factor involved in regulating basaland induced expression of genes of the purineand histidine biosynthesis pathways 0.026160.08436&radic S000001747GAP1YKR039WverifiedGeneral amino acid permease; localization to the plasmamembrane is regulated by nitrogen source 0.026010.08375 S000000752SNU13YEL026WverifiedRNA binding protein, part of U3 snoRNP involved in rRNAprocessing, part of U4/U6-U5 tri-snRNP involvedin mRNA splicing, similar to human 15.5Kprotein 0.025940.08347&radic&radic&radic&radic&radic S000003274YGR042WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 0.025920.0834&radic&radic&radic&radic&radic&radic S000004868GFD1YMR255WverifiedCoiled-coiled protein of unknown function, identified as ahigh-copy suppressor of a dbp5 mutation 0.02590.08339&radic&radic&radic&radic&radic S000005621RKI1YOR095CverifiedRibose-5-phosphate ketol-isomerase, catalyzes theinterconversion of ribose 5-phosphate andribulose 5-phosphate in the pentose phosphatepathway; participates in pyridoxinebiosynthesis 0.025890.08321&radic&radic&radic&radic&radic&radic S000006067NOP53YPL146CverifiedNucleolar protein; involved in biogenesis of the 60S subunit ofthe ribosome; interacts with rRNA processingfactors Cbf5p and Nop2p; null mutant is viablebut growth is severely impaired 0.025850.08319&radic S000000122LSM2YBL026WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.025820.08306&radic&radic&radic&radic&radic S000000393RPS9BYBR189WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps9Ap and has similarity to E.coli S4 and rat S9 ribosomal proteins 0.02580.08302&radic S000002300BPL1YDL141WverifiedBiotin:apoprotein ligase, covalently modifies proteins with theaddition of biotin, required for acetyl-CoAcarboxylase (Acc1p) holoenzyme formation 0.025790.08298&radic&radic S000003507RTT102YGR275WverifiedComponent of both the SWI/SNF and RSC chromatin remodelingcomplexes, suggested role in chromosomemaintenance; possible weak regulator of Ty1transposition 0.025680.08254&radic&radic&radic&radic S000005755WTM2YOR229WverifiedTranscriptional repressor involved in regulation of meiosis andsilencing; contains WD repeats 0.025590.08226&radic&radic&radic&radic S000002520PDS1YDR113CverifiedSecurin that inhibits anaphase by binding separin Esp1p, alsoblocks cyclin destruction and mitotic exit,essential for cell cycle arrest in mitosis inthe presence of DNA damage or aberrant mitoticspindles; also present in meiotic nuclei 0.025570.0822&radic&radic&radic&radic&radic&radic S000001334HOP1YIL072WverifiedMeiosis-specific DNA binding protein that displays Red1pdependent localization to the unsynapsedaxial-lateral elements of the synaptonemalcomplex; required for homologous chromosomesynapsis and chiasma formation 0.025560.08202&radic&radic&radic&radic&radic&radic&radic S000004017AAT2YLR027CverifiedCytosolic aspartate aminotransferase, involved in nitrogenmetabolism; localizes to peroxisomes inoleate-grown cells 0.025470.08181&radic&radic&radic&radic&radic S000005257YNL313CUncharacterizedProtein required for cell viability 0.025470.08181&radic&radic&radic&radic&radic&radic&radic S000004783HOT1YMR172WverifiedTranscription factor required for the transient induction ofglycerol biosynthetic genes GPD1 and GPP2 inresponse to high osmolarity; targets Hog1p toosmostress responsive promoters; has similarityto Msn1p and Gcr1p 0.025440.08172&radic S000006348NOC4YPR144CverifiedNucleolar protein, forms a complex with Nop14p that mediatesmaturation and nuclear export of 40S ribosomalsubunits 0.025420.08163&radic&radic&radic&radic&radic S000003340CLB1YGR108WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the transition from G2 to Mphase; accumulates during G2 and M, thentargeted via a destruction box motif forubiquitin-mediated degradation by theproteasome 0.025430.08163&radic&radic&radic&radic&radic&radic&radic S000004081YLR091WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR091W is not an esssential gene 0.025390.08146&radic&radic&radic&radic S000004256PDR8YLR266CverifiedTranscription factor; targets include ATP-binding cassette(ABC) transporters, major facilitatorsuperfamily transporters, and other genesinvolved in the pleiotropic drug resistance(PDR) phenomenon 0.02530.08114&radic&radic&radic&radic&radic&radic S000005051YAF9YNL107WverifiedSubunit of both the NuA4 histone H4 acetyltransferase complexand the SWR1 complex, may function toantagonize silencing near telomeres; interactsdirectly with Swc4p, has homology to humanleukemogenic protein AF9, contains a YEATSdomain 0.025270.08113&radic&radic S000000238HMT1YBR034CverifiedNuclear SAM-dependent mono- and asymmetric argininedimethylating methyltransferase that modifieshnRNPs, including Npl3p and Hrp1p, thusfacilitating nuclear export of these proteins;required for viability of npl3 mutants 0.025210.08083&radic&radic S000002699HRQ1YDR291WuncharacterizedPutative DNA helicase 0.025160.08069&radic&radic&radic&radic&radic S000002600NUP42YDR192CverifiedSubunit of the nuclear pore complex (NPC) that localizesexclusively to the cytoplasmic side; involvedin RNA export, most likely at a terminal step;interacts with Gle1p 0.025150.08069&radic&radic&radic&radic S000005192RPA49YNL248CverifiedRNA polymerase I subunit A49 0.025160.08069&radic&radic&radic&radic S000006014NOG1YPL093WverifiedPutative GTPase that associates with free 60S ribosomalsubunits in the nucleolus and is required for60S ribosomal subunit biogenesis; constituentof 66S pre-ribosomal particles; member of theODN family of nucleolar G-proteins 0.025130.08064&radic&radic&radic S000005145PSY2YNL201CverifiedPutative subunit of an evolutionarily conserved proteinphosphatase complex containing the catalyticsubunit Pph3p and the regulatory subunit Psy4p;required for cisplatin and oxaliplatinresistance; localizes to nucleus 0.025120.08064&radic&radic&radic&radic&radic&radic&radic S000006379DPB2YPR175WverifiedSecond largest subunit of DNA polymerase II (DNA polymeraseepsilon), required for normal yeast chromosomalreplication; expression peaks at the G1/S phaseboundary; potential Cdc28p substrate 0.025080.08043&radic&radic S000005372HTZ1YOL012CverifiedHistone variant H2AZ, exchanged for histone H2A in nucleosomesby the SWR1 complex; involved intranscriptional regulation through preventionof the spread of silent heterochromatin 0.025090.08043&radic&radic S000005933RRP12YPL012WverifiedProtein required for export of the ribosomal subunits;associates with the RNA components of thepre-ribosomes; contains HEAT-repeats 0.024980.08017&radic&radic&radic&radic&radic S000004158YLR168CUncharacterizedPutative protein of unknown function that may be involved in intramitochondrial sorting; has similarity to Ups1p and to human PRELI; the green fluorescent protein (GFP)-tagged protein localizes to mitochondria 0.024960.08011 S000003730CDC6YJL194WverifiedEssential ATP-binding protein required for DNA replication,component of the pre-replicative complex(pre-RC) which requires ORC to associate withchromatin and is in turn required for Mcm2-7pDNA association; homologous to S. pombe Cdc18p 0.024860.07972&radic&radic&radic&radic&radic&radic S000005373HRD1YOL013CverifiedUbiquitin-protein ligase required for endoplasmicreticulum-associated degradation (ERAD) ofmisfolded proteins; genetically linked to theunfolded protein response (UPR); regulatedthrough association with Hrd3p; contains an H2ring finger 0.024850.07969&radic&radic&radic&radic S000005081NAM9YNL137CverifiedMitochondrial ribosomal component of the small subunit 0.024830.07963 S000002490RRP8YDR083WverifiedNucleolar protein involved in rRNA processing, pre-rRNAcleavage at site A2; also involved in telomeremaintenance; mutation is synthetically lethalwith a gar1 mutation 0.024810.07955&radic&radic&radic&radic S000002211PBP4YDL053CverifiedPbp1p binding protein, interacts strongly with Pab1p-bindingprotein 1 (Pbp1p) in the yeast two-hybridsystem; also interacts with Lsm12p in acopurification assay 0.024750.07934&radic&radic S000001789RPF2YKR081CverifiedEssential protein involved in the processing of pre-rRNA andthe assembly of the 60S ribosomal subunit;interacts with ribosomal protein L11; localizespredominantly to the nucleolus; constituent of66S pre-ribosomal particles 0.02470.07921&radic&radic&radic S000003623TRL1YJL087CverifiedtRNA ligase, required for tRNA splicing; composed of threeessential domains containing thephosphodiesterase, polynucleotide kinase, andligase activities required for ligation;localized at the inner membrane of the nuclearenvelope &radic0.02470.07921&radic S000002796RVS167YDR388WverifiedActin-associated protein, subunit of a complex(Rvs161p-Rvs167p) involved in regulation ofactin cytoskeleton, endocytosis, and viabilityfollowing starvation or osmotic stress; homologof mammalian amphiphysin 0.024680.07907&radic&radic&radic&radic&radic S000004914DYN3YMR299CverifiedDynein light intermediate chain (LIC); localizes with dynein,null mutant is defective in nuclear migration 0.024620.07892&radic&radic&radic&radic&radic S000000018ATS1YAL020CverifiedProtein required, with Elongator complex, Kti11p, and Kti12p,for modification of wobble nucleosides in tRNA;has a potential role in regulatory interactionsbetween microtubules and the cell cycle &radic0.024570.07875&radic&radic&radic&radic S000002598RVB1YDR190CverifiedEssential protein involved in transcription regulation;component of chromatin remodeling complexes;required for assembly and function of the INO80complex; member of the RUVB-like protein family 0.024510.07838&radic&radic&radic&radic S000003557BBC1YJL020CverifiedProtein possibly involved in assembly of actin patches;interacts with an actin assembly factor Las17pand with the SH3 domains of Type I myosinsMyo3p and Myo5p; localized predominantly tocortical actin patches 0.024460.0783 S000002769BCP1YDR361CverifiedEssential protein involved in nuclear export of Mss4p, which isa lipid kinase that generatesphosphatidylinositol 4,5-biphosphate and playsa role in actin cytoskeleton organization andvesicular transport 0.024460.0783&radic&radic&radic&radic&radic&radic&radic S000005497BSC6YOL137WverifiedProtein of unknown function containing 8 putative transmembraneseqments; ORF exhibits genomic organizationcompatible with a translationalreadthrough-dependent mode of expression 0.024340.07788 S000004069SIC1YLR079WverifiedInhibitor of Cdc28-Clb kinase complexes that controls G1/Sphase transition, preventing premature S phaseand ensuring genomic integrity; phosphorylationtargets Sic1p for SCF(CDC4)-dependent turnover;functional homolog of mammalian Kip1 0.024310.07781&radic&radic&radic&radic&radic&radic S000003038RPB9YGL070CverifiedRNA polymerase II subunit B12.6; contacts DNA; mutations affecttranscription start site; involved in telomeremaintenance 0.024290.07774&radic&radic&radic&radic&radic&radic S000005743RFC1YOR217WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon 0.024290.07774&radic&radic&radic&radic&radic&radic S000005481RPS19AYOL121CverifiedProtein component of the small (40S) ribosomal subunit,required for assembly and maturation of pre-40S particles; mutations in human RPS19 areassociated with Diamond Blackfan anemia; nearlyidentical to Rps19Bp 0.024270.07766&radic S000006161HSP82YPL240CverifiedCytoplasmic chaperone (Hsp90 family) required for pheromonesignaling and negative regulation of Hsf1p;docks with the mitochondrial import receptorTom70p for preprotein delivery; interacts withco-chaperones Cns1p, Cpr6p, Cpr7p, and Sti1p 0.024250.07759&radic&radic&radic S000002562CPR1YDR155CverifiedCytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin),catalyzes the cis-trans isomerization ofpeptide bonds N-terminal to proline residues;binds the drug cyclosporin A 0.024240.07759&radic&radic&radic&radic&radic S000004109SRN2YLR119WverifiedComponent of the ESCRT-I complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; suppressor of rna1-1 mutation;may be involved in RNA export from nucleus 0.024230.07759&radic&radic&radic&radic S000004322CHS5YLR330WverifiedProtein involved in export from the Golgi to plasma membrane;involved in chitin biosynthesis through itsrole in Chs3p localization; interacts withArf1p, Bch1p, Fmp50p, Bud7p, and Chs6p 0.024240.07759&radic&radic&radic&radic S000003957RIX7YLL034CverifiedPutative ATPase of the AAA family, required for export ofpre-ribosomal large subunits from the nucleus;distributed between the nucleolus, nucleoplasm,and nuclear periphery depending on growthconditions 0.024230.0775&radic&radic&radic&radic&radic&radic&radic S000001220YHR177WUncharacterized 0.02420.07745&radic&radic&radic&radic S000001803MLP1YKR095WverifiedMyosin-like protein associated with the nuclear envelope,connects the nuclear pore complex with thenuclear interior; involved with Tel1p intelomere length control; involved with Pml1pand Pml39p in nuclear retention of unsplicedmRNAs 0.024110.077 S000003704SET2YJL168CverifiedHistone methyltransferase with a role in transcriptionalelongation, methylates a lysine residue ofhistone H3; associates with the C-terminaldomain of Rpo21p; histone methylation activityis regulated by phosphorylation status ofRpo21p 0.024130.077&radic&radic&radic&radic&radic&radic&radic S000000132YBL036CVerifiedSingle-domain racemase, possibly non-specific due to the lack of the second domain, which presumably determines specificity 0.024130.077&radic&radic S000004255NEJ1YLR265CverifiedProtein involved in regulation of nonhomologous end joining;repressed by MAT heterozygosity; associateswith Lif1p and regulates its cellulardistribution 0.02410.077&radic&radic&radic&radic&radic&radic&radic&radic S000005756WTM1YOR230WverifiedTranscriptional repressor involved in regulation of meiosis andsilencing; contains WD repeats 0.024130.077&radic&radic&radic&radic&radic S000004097REX3YLR107WverifiedRNA exonuclease; required for maturation of the RNA componentof RNase MRP; functions redundantly with Rnh70pand Rex2p in processing of U5 snRNA and RNase PRNA; member of RNase D family of exonucleases 0.024070.07696&radic&radic&radic&radic&radic&radic&radic S000000377UMP1YBR173CverifiedShort-lived chaperone required for correct maturation of the20S proteasome; degraded by proteasome uponcompletion of its assembly; involved inubiquitin-mediated proteolysis; mutantdefective in degradation of short-livedproteins 0.024060.07693&radic&radic&radic&radic&radic S000004137SMD3YLR147CverifiedCore Sm protein Sm D3; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D3 0.024030.0768&radic&radic&radic&radic&radic S000003628HPR5YJL092WverifiedDNA helicase and DNA-dependent ATPase involved in DNA repair,required for proper timing of commitment tomeiotic recombination and the transition fromMeiosis I to Meiosis II; potential Cdc28psubstrate 0.023990.07667&radic S000000358RPB5YBR154CverifiedRNA polymerase subunit ABC27, common to RNA polymerases I, II,and III; contacts DNA and affectstransactivation 0.023970.07648 S000000729GIM4YEL003WverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.023910.07634&radic&radic&radic&radic&radic&radic S000003553YJL016WUncharacterizedPutative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species 0.023890.0762&radic S000002307NOP14YDL148CverifiedNucleolar protein, forms a complex with Noc4p that mediatesmaturation and nuclear export of 40S ribosomalsubunits; also present in the small subunitprocessome complex, which is required forprocessing of pre-18S rRNA 0.02390.0762 S000003842EAF6YJR082CuncharacterizedEsa1p-associated factor, subunit of the NuA4 acetyltransferasecomplex 0.023860.07615&radic S000000162SEF1YBL066CverifiedPutative transcription factor, has homolog in Kluyveromyceslactis 0.023850.0761&radic&radic&radic S000002335YDL176WUncharacterizedHypothetical protein 0.023830.07602 S000000227CHS3YBR023CverifiedChitin synthase III, catalyzes the transfer ofN-acetylglucosamine (GlcNAc) to chitin;required for synthesis of the majority of cellwall chitin, the chitin ring during budemergence, and spore wall chitosan 0.023760.0758 S000001458MUC1YIR019CverifiedGPI-anchored cell surface glycoprotein required for diploidpseudohyphal formation and haploid invasivegrowth, transcriptionally regulated by the MAPKpathway (via Ste12p and Tec1p) and the cAMPpathway (via Flo8p) 0.023740.07574&radic S000005180SIN4YNL236WverifiedSubunit of the Mediator complex; interacts with the RNApolymerase II holoenzyme to postively ornegatively regulate transcription; dispensiblefor basal transcription 0.023680.07551&radic&radic&radic&radic&radic&radic S000003463PHB2YGR231CverifiedSubunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDaring-shaped inner mitochondrial membranechaperone that stabilizes newly synthesizedproteins; determinant of replicative life span;involved in mitochondrial segregation 0.023670.07551&radic&radic&radic&radic&radic S000001246RPS4BYHR203CverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps4Ap and has similarity to ratS4 ribosomal protein 0.023650.07546&radic&radic&radic&radic S000000540GRX1YCL035CverifiedHydroperoxide and superoxide-radical responsive heat-stableglutathione-dependent disulfide oxidoreductasewith active site cysteine pair; protects cellsfrom oxidative damage 0.023650.07542&radic&radic S000003202SEC15YGL233WverifiedEssential 113kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which mediates polarized targeting ofvesicles to active sites of exocytosis; Sec15passociates with Sec4p and vesicles 0.023640.07542&radic&radic&radic S000005485TRM13YOL125WuncharacterizedHypothetical protein 0.023620.07535&radic&radic S000001586LAP4YKL103CverifiedVacuolar aminopeptidase, often used as a marker protein instudies of autophagy and cytosol to vacuoletargeting (CVT) pathway 0.023630.07535&radic&radic&radic&radic&radic&radic&radic&radic S000000781POL5YEL055CverifiedProtein with sequence similarity to the human MybBP1A and weaksequence similar to B-type DNA polymerases, notrequired for chromosomal DNA replication;required for the synthesis of rRNA 0.023610.07523&radic&radic&radic&radic&radic S000002545HPR1YDR138WverifiedSubunit of THO/TREX complexes that couple transcriptionelongation with mitotic recombination and withmRNA metabolism and export, subunit of an RNAPol II complex; regulates lifespan; involved intelomere maintenance; similar to Top1p 0.023560.07515&radic&radic&radic&radic&radic&radic&radic S000001591SLD2YKL108WverifiedProtein required for DNA replication, phosphorylated in S phaseby S-phase cyclin-dependent kinases (Cdks),phosphorylation is essential for DNAreplication and for complex formation withDpb11p; potential Cdc28p substrate 0.023570.07515&radic&radic&radic&radic&radic S000001191IMP3YHR148WverifiedComponent of the SSU processome, which is required for pre-18SrRNA processing, essential protein thatinteracts with Mpp10p and mediates interactionsof Imp4p and Mpp10p with U3 snoRNA 0.023530.07503&radic&radic&radic&radic S000002279YDL121CUncharacterizedHypothetical protein 0.023480.07484 S000001052RPL27AYHR010WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl27Bp and has similarity to ratL27 ribosomal protein 0.023470.0748&radic&radic&radic&radic&radic S000001283RPB3YIL021WverifiedRNA polymerase II third largest subunit B44, part of centralcore; similar to prokaryotic alpha subunit 0.023450.0747&radic&radic&radic&radic S000002838CYM1YDR430CverifiedLysine-specific metalloprotease of the mitochondrialintermembrane space, member of the pitrilysinfamily; degrades proteins and presequencepeptides cleaved from imported proteins;required for normal mitochondrial morphology 0.023450.0747&radic&radic&radic&radic&radic S000002820RRP17YDR412WuncharacterizedProtein required for cell viability 0.023450.0747&radic&radic&radic&radic S000006305SNT309YPR101WverifiedComponent of NineTeen complex (NTC) containing Prp19p involvedin mRNA splicing, interacts physically andgenetically with Prp19p 0.02340.07454&radic S000001335SPO22YIL073CverifiedMeiosis-specific protein essential for chromosome synapsis,similar to phospholipase A2, involved incompletion of nuclear divisions during meiosis;induced early in meiosis 0.023370.07446&radic&radic&radic&radic&radic S000001871BUD27YFL023WverifiedProtein involved in bud-site selection, nutrient signaling, andgene expression controlled by the TOR kinase;diploid mutants display a random buddingpattern instead of the wild-type bipolarpattern 0.023370.07446&radic&radic&radic&radic&radic&radic S000003906RPS4AYJR145CverifiedProtein component of the small (40S) ribosomal subunit;mutation affects 20S pre-rRNA processing;identical to Rps4Bp and has similarity to ratS4 ribosomal protein 0.023360.07444&radic S000002336YDL177CUncharacterizedHypothetical protein 0.023340.07436 S000004029RIC1YLR039CverifiedProtein involved in retrograde transport to the cis-Golginetwork; forms heterodimer with Rgp1p that actsas a GTP exchange factor for Ypt6p; involved intranscription of rRNA and ribosomal proteingenes 0.023350.07436 S000000455MRPS5YBR251WverifiedMitochondrial ribosomal protein of the small subunit 0.023340.07436&radic&radic S000000406CDC47YBR202WverifiedComponent of the hexameric MCM complex, which is important forpriming origins of DNA replication in G1 andbecomes an active ATP-dependent helicase thatpromotes DNA melting and elongation whenactivated by Cdc7p-Dbf4p in S-phase 0.023320.07423&radic&radic&radic&radic&radic&radic&radic S000006138BMS1YPL217CverifiedEssential conserved nucleolar GTP-binding protein required forsynthesis of 40S ribosomal subunits and forprocessing of the 35S pre-rRNA at sites A0, A1,and A2; interacts with Rcl1p, has similarity toTsr1p 0.023310.07423 S000000124YBL028CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis 0.023140.07369&radic S000002172NOP1YDL014WverifiedNucleolar protein, component of the small subunit processomecomplex, which is required for processing ofpre-18S rRNA; has similarity to mammalianfibrillarin 0.023130.07359 S000006312RPN7YPR108WverifiedEssential, non-ATPase regulatory subunit of the 26S proteasome,similar to another S. cerevisiae regulatorysubunit, Rpn5p, as well as to mammalianproteasome subunits 0.023080.07344&radic&radic&radic&radic S000004312MMS22YLR320WverifiedProtein involved in resistance to ionizing radiation; acts withMms1p in a repair pathway that may be involvedin resolving replication intermediates orpreventing the damage caused by blockedreplication forks 0.023070.07344&radic&radic&radic&radic S000001131GAR1YHR089CverifiedProtein component of the H/ACA snoRNP pseudouridylase complex,involved in the modification and cleavage ofthe 18S pre-rRNA 0.023050.07338 S000005072TEP1YNL128WverifiedHomolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that haslipid phosphatase activity and is linked to thephosphatidylinositol signaling pathway; plays arole in normal sporulation 0.023050.07337 S000001463YIR024CUncharacterizedPutative protein of unknown function; GFP-fusion protein localizes to mitochondria and native protein copurifies with mitochondria; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect 0.022940.07296&radic&radic&radic&radic&radic S000004252YPT6YLR262CverifiedGTPase, Ras-like GTP binding protein involved in the secretorypathway, required for fusion ofendosome-derived vesicles with the late Golgi,maturation of the vacuolar carboxypeptidase Y;has similarity to the human GTPase, Rab6 0.022910.07287&radic&radic&radic&radic&radic&radic S000000866YER064CUncharacterizedNon-essential nuclear protein; null mutation has global effects on transcription 0.022910.07287&radic S000005097GIM3YNL153CverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.022890.0728&radic&radic&radic&radic S000002569NBP2YDR162CverifiedProtein involved in the HOG (high osmolarity glycerol) pathway,negatively regulates Hog1p by recruitment ofphosphatase Ptc1p the Pbs2p-Hog1p complex,found in the nucleus and cytoplasm, contains anSH3 domain that binds Pbs2p 0.022810.07259&radic&radic&radic&radic&radic S000005617TMA46YOR091WverifiedProtein of unknown function that associates with ribosomes;interacts with GTPase Rbg1p 0.022830.07259&radic&radic&radic&radic&radic S000005480RPL18AYOL120CverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl18Bp and has similarity to ratL18 ribosomal protein; intron of RPL18Apre-mRNA forms stem-loop structures that are atarget for Rnt1p cleavage leading todegradation 0.022820.07259 S000001198YSP1YHR155WuncharacterizedMitochondrial protein with a potential role in promotingmitochondrial fragmentation during programmedcell death in response to high levels ofalpha-factor mating pheromone or the drugamiodarone 0.02280.07258&radic&radic&radic&radic&radic&radic&radic S000006132NIP7YPL211WverifiedNucleolar protein required for 60S ribosome subunit biogenesis,constituent of 66S pre-ribosomal particles;physically interacts with Nop8p and the exosomesubunit Rrp43p 0.022770.07246&radic&radic&radic S000004722ASC1YMR116CverifiedWD repeat protein (G-beta like protein) involved in translationregulation; required for repression of Gcn4pactivity in the absence of amino-acidstarvation; core component of the ribosome;ortholog of mammalian RACK1 0.022760.0724 S000000824SRB4YER022WverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation 0.022750.07238&radic&radic&radic&radic&radic&radic&radic&radic S000006236SRO7YPR032WverifiedPutative effector of Rab GTPase Sec4p, forms a complex withSec4p and t-SNARE Sec9p; involved in exocytosisand docking and fusion of post-Golgi vesicleswith plasma membrane; homolog of Sro77p andDrosophila lgl tumor suppressor 0.022740.07237&radic S000004685NAM7YMR080CverifiedATP-dependent RNA helicase of the SFI superfamily, required fornonsense mediated mRNA decay and for efficienttranslation termination at nonsense codons;involved in telomere maintenance 0.022740.07236&radic S000001578YJU2YKL095WverifiedEssential nuclear protein; putative spliceosomal componentinvolved in mRNA splicing, based oncomputational analysis of large-scaleprotein-protein interaction data 0.022690.07221&radic&radic&radic&radic&radic&radic S000005498YOL138CUncharacterizedHypothetical protein 0.022690.0721 S000005355HXT17YNR072WverifiedHexose transporter, up-regulated in media containing raffinoseand galactose at pH 7.7 versus pH 4.7,repressed by high levels of glucose 0.02260.07183 S000005671PNO1YOR145CverifiedEssential nucleolar protein required for pre-18S rRNAprocessing, interacts with Dim1p, an 18S rRNAdimethyltransferase, and also with Nob1p, whichis involved in proteasome biogenesis; containsa KH domain 0.022580.07179&radic&radic S000004173TOS4YLR183CverifiedTranscription factor that binds to a number of promoterregions, particularly promoters of some genesinvolved in pheromone response and cell cycle;potential Cdc28p substrate; expression isinduced in G1 by bound SBF 0.022550.07167&radic&radic&radic&radic&radic&radic S000000743GTT3YEL017WuncharacterizedProtein of unknown function with a possible role in glutathionemetabolism, as suggested by computationalanalysis of large-scale protein-proteininteraction data; GFP-fusion protein localizesto the nuclear periphery 0.022520.07157&radic&radic&radic&radic&radic S000000243ATP3YBR039WverifiedGamma subunit of the F1 sector of mitochondrial F1F0 ATPsynthase, which is a large, evolutionarilyconserved enzyme complex required for ATPsynthesis 0.022510.07153 S000001234CTF8YHR191CverifiedSubunit of a complex with Ctf18p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion 0.022460.07134 S000002577SEC7YDR170CverifiedGuanine nucleotide exchange factor (GEF) for ADP ribosylationfactors involved in proliferation of the Golgi,intra-Golgi transport and ER-to-Golgitransport; found in the cytoplasm and onGolgi-associated coated vesicles 0.022450.07134&radic&radic&radic&radic S000002482PPH3YDR075WverifiedCatalytic subunit of an evolutionarily conserved proteinphosphatase complex containing Psy2p and theregulatory subunit Psy4p; required forcisplatin resistance; involved in activation ofGln3p 0.022470.07134&radic&radic&radic&radic&radic&radic&radic&radic S000001946PRE4YFR050Cverified20S proteasome beta-type subunit 0.022450.0713&radic&radic&radic&radic&radic S000004927YMR310CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene 0.022420.07122&radic&radic&radic&radic&radic S000000638TAF2YCR042CverifiedTFIID subunit (150 kDa), involved in RNA polymerase IItranscription initiation 0.022390.07111&radic S000003616SCP160YJL080CverifiedEssential RNA-binding G protein effector of mating responsepathway, predominantly associated with nuclearenvelope and ER, interacts in mRNA-dependentmanner with translating ribosomes via multipleKH domains, similar to vertebrate vigilins 0.022390.07111 S000002200SIR2YDL042CverifiedConserved NAD+ dependent histone deacetylase of the Sirtuinfamily involved in regulation of lifespan;plays roles in silencing at HML, HMR,telomeres, and the rDNA locus; negativelyregulates initiation of DNA replication 0.022360.07097 S000002303YDL144CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene. 0.022380.07097&radic&radic S000001607SSH4YKL124WverifiedProtein whose overexpression confers resistance to the growthinhibitor leflunomide; suppressor of shr3mutation 0.022380.07097&radic&radic&radic&radic S000001409SLN1YIL147CverifiedHistidine kinase osmosensor that regulates a MAP kinasecascade; transmembrane protein with anintracellular kinase domain that signals toYpd1p and Ssk1p, thereby forming a phosphorelaysystem similar to bacterial two-componentregulators 0.022260.07065 S000004754TIF34YMR146CverifiedSubunit of the core complex of translation initiation factor3(eIF3), which is essential for translation 0.022260.07058&radic&radic&radic&radic S000001243RPN10YHR200WverifiedNon-ATPase base subunit of the 19S regulatory particle (RP) ofthe 26S proteasome; N-terminus plays a role inmaintaining the structural integrity of the RP;binds selectively to polyubiquitin chains;homolog of the mammalian S5a protein 0.022240.07056&radic&radic&radic&radic&radic S000005888PRT1YOR361CverifiedSubunit of the core complex of translation initiation factor3(eIF3), essential for translation; part of asubcomplex (Prt1p-Rpg1p-Nip1p) that stimulatesbinding of mRNA and tRNA(i)Met to ribosomes 0.022230.07048&radic&radic&radic&radic&radic S000000968DNF1YER166WverifiedAminophospholipid translocase (flippase) that localizesprimarily to the plasma membrane; contributesto endocytosis, protein transport and cellpolarity; type 4 P-type ATPase 0.022180.0702 S000005820RRS1YOR294WverifiedEssential protein that binds ribosomal protein L11 and isrequired for nuclear export of the 60Spre-ribosomal subunit during ribosomebiogenesis; mouse homolog shows alteredexpression in Huntington's disease model mice 0.022180.0702&radic&radic&radic&radic&radic S000002419RPL4BYDR012WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl4Ap and has similarity to E.coli L4 and rat L4 ribosomal proteins 0.022170.0702&radic S000001012OPI1YHL020CverifiedTranscriptional regulator of a variety of genes;phosphorylation by protein kinase A stimulatesOpi1p function in negative regulation ofphospholipid biosynthetic genes; involved intelomere maintenance 0.022170.0702&radic&radic&radic&radic&radic S000000520BUD3YCL014WverifiedProtein involved in bud-site selection and required for axialbudding pattern; localizes with septins to budneck in mitosis and may constitute an axiallandmark for next round of budding 0.022160.0702&radic&radic&radic&radic&radic S000003088PRP43YGL120CverifiedRNA helicase in the DEAH-box family, functions in both RNApolymerase I and polymerase II transcriptmetabolism, involved in release of thelariat-intron from the spliceosome 0.022110.07006 S000000928NSA2YER126CverifiedConstituent of 66S pre-ribosomal particles, involved in 60Sribosomal subunit biogenesis 0.022080.06992&radic S000003310PAC10YGR078CverifiedPart of the heteromeric co-chaperone GimC/prefoldin complex,which promotes efficient protein folding 0.022050.06984&radic&radic&radic&radic S000002536SAC6YDR129CverifiedFimbrin, actin-bundling protein; cooperates with Scp1p(calponin/transgelin) in the organization andmaintenance of the actin cytoskeleton 0.022040.06979&radic&radic&radic&radic&radic S000001297CKA1YIL035CverifiedAlpha catalytic subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA2, CKB1 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.022020.06976&radic&radic&radic&radic&radic&radic S000004559GIM5YML094WverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.0220.06967&radic S000001953YFR057WUncharacterizedHypothetical protein 0.021970.06955&radic&radic&radic&radic S000004070EMP46YLR080WverifiedIntegral membrane component of endoplasmic reticulum-derivedCOPII-coated vesicles, which function in ER toGolgi transport 0.021970.0695&radic&radic&radic&radic&radic&radic&radic S000005242CLA4YNL298WverifiedCdc42p activated signal transducing kinase of the PAK(p21-activated kinase) family, involved inseptin ring assembly and cytokinesis; directlyphosphorylates septins Cdc3p and Cdc10p; otheryeast PAK family members are Ste20p and Skm1p 0.021910.06932&radic&radic&radic&radic S000002189DBP10YDL031WverifiedPutative ATP-dependent RNA helicase of the DEAD-box proteinfamily, constituent of 66S pre-ribosomalparticles; essential protein involved inribosome biogenesis 0.02190.06926 S000003440SER2YGR208WverifiedPhosphoserine phosphatase of the phosphoglycerate pathway,involved in serine and glycine biosynthesis,expression is regulated by the availablenitrogen source 0.021880.0692&radic&radic&radic&radic&radic S000001108SSF1YHR066WverifiedConstituent of 66S pre-ribosomal particles, required forribosomal large subunit maturation;functionally redundant with Ssf2p; member ofthe Brix family 0.021880.0692&radic&radic&radic&radic S000000004SSA1YAL005CverifiedATPase involved in protein folding and nuclear localizationsignal (NLS)-directed nuclear transport; memberof heat shock protein 70 (HSP70) family; formsa chaperone complex with Ydj1p; localized tothe nucleus, cytoplasm, and cell wall 0.021830.06906&radic&radic&radic&radic&radic&radic&radic S000006322YPR118WVerifiedMethylthioribose-1-phosphate isomerase, catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway 0.021850.06906&radic&radic S000000950SPT15YER148WverifiedTATA-binding protein, general transcription factor thatinteracts with other factors to form thepreinitiation complex at promoters, essentialfor viability 0.021830.06901&radic S000003973COF1YLL050CverifiedCofilin, promotes actin filament depolarization in apH-dependent manner; binds both actin monomersand filaments and severs filaments , thought tobe regulated by phosphorylation at SER4,ubiquitous and essential in eukaryotes 0.021810.06892&radic&radic&radic&radic S000004282GCD7YLR291CverifiedBeta subunit of the translation initiation factor eIF2B, theguanine-nucleotide exchange factor for eIF2;activity subsequently regulated byphosphorylated eIF2; first identified as anegative regulator of GCN4 expression 0.021770.06884&radic&radic&radic&radic S000004497SRC1YML034WverifiedProtein with a putative role in sister chromatid segregation,potentially phosphorylated by Cdc28p; greenfluorescent protein (GFP)-fusion proteinlocalizes to the nuclear periphery 0.021780.06884&radic&radic&radic S000006290SUA7YPR086WverifiedTranscription factor TFIIB, a general transcription factorrequired for transcription initiation and startsite selection by RNA polymerase II 0.021750.06874&radic S000002719TFB1YDR311WverifiedSubunit of TFIIH and nucleotide excision repair factor 3complexes, required for nucleotide excisionrepair, target for transcriptional activators 0.021640.06841&radic&radic&radic&radic&radic S000002612COQ4YDR204WverifiedProtein with a role in ubiquinone (Coenzyme Q) biosynthesis,possibly functioning in stabilization of Coq7p;located on the matrix face of the mitochondrialinner membrane; component of a mitochondrialubiquinone-synthesizing complex 0.021610.06831&radic&radic&radic&radic&radic&radic S000000294YBR090CUncharacterizedHypothetical protein 0.021540.06805&radic&radic S000005580VHS3YOR054CverifiedFunctionally redundant (see also SIS2) inhibitory subunit ofPpz1p, a PP1c-related ser/thr proteinphosphatase Z isoform; synthetically lethalwith sis2; putative phosphopantothenoylcysteinedecarboxylase involved in coenzyme Abiosynthesis 0.021540.06805&radic&radic&radic S000001622CTK1YKL139WverifiedCatalytic (alpha) subunit of C-terminal domain kinase I(CTDK-I), which phosphorylates the C-terminalrepeated domain of the RNA polymerase II largesubunit (Rpo21p) to affect both transcriptionand pre-mRNA 3' end processing 0.021540.06805&radic&radic&radic&radic&radic S000002656YDR248CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.021520.06788&radic&radic&radic S000001924CDC14YFR028CverifiedProtein phosphatase required for mitotic exit; located in thenucleolus until liberated by the FEAR andMitotic Exit Network in anaphase, enabling itto act on key substrates to effect a decreasein CDK/B-cyclin activity and mitotic exit 0.021470.06773 S000004424IMD3YLR432WverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 0.021370.06749&radic S000001356LYS12YIL094CverifiedHomo-isocitrate dehydrogenase, an NAD-linked mitochondrialenzyme required for the fourth step in thebiosynthesis of lysine, in whichhomo-isocitrate is oxidatively decarboxylatedto alpha-ketoadipate 0.021380.06749 S000000165AST1YBL069WverifiedPeripheral membrane protein that interacts with the plasmamembrane ATPase Pma1p and has a role in itstargeting to the plasma membrane, possibly byinfluencing its incorporation into lipid rafts 0.02130.06713&radic&radic&radic&radic&radic&radic&radic&radic S000000301VPS15YBR097WverifiedMyristoylated serine/threonine protein kinase involved invacuolar protein sorting; functions as amembrane-associated complex with Vps34p; activeform recruits Vps34p to the Golgi membrane;interacts with the GDP-bound form of Gpa1p 0.021260.06699 S000004865YMR252CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene 0.021220.06694&radic&radic S000004681PDS5YMR076CverifiedProtein required for establishment and maintenance of sisterchromatid condensation and cohesion,colocalizes with cohesin on chromosomes in aninterdependent manner, may function as aprotein-protein interaction scaffold 0.021230.06694&radic S000002246ASM4YDL088CverifiedNuclear pore complex subunit, part of a subcomplex alsocontaining Nup53p, Nup170p, and Pse1p 0.02120.06687 S000002865TOM1YDR457WverifiedE3 ubiquitin ligase of the hect-domain class; has a role inmRNA export from the nucleus and may regulatetranscriptional coactivators 0.021190.06684&radic S000001072SLT2YHR030CverifiedSerine/threonine MAP kinase involved in regulating themaintenance of cell wall integrity andprogression through the cell cycle; regulatedby the PKC1-mediated signaling pathway 0.021170.0668&radic&radic&radic&radic&radic&radic S000000452HIS7YBR248CverifiedImidazole glycerol phosphate synthase (glutamineamidotransferase:cyclase), catalyzes the fifthand sixth steps of histidine biosynthesis andalso produces 5-aminoimidazole-4-carboxamideribotide (AICAR), a purine precursor 0.021140.0667&radic&radic&radic&radic&radic S000002861TSA2YDR453CverifiedStress inducible cytoplasmic thioredoxin peroxidase; cooperateswith Tsa1p in the removal of reactive oxygen,nitrogen and sulfur species using thioredoxinas hydrogen donor; deletion enhances themutator phenotype of tsa1 mutants 0.021110.06659&radic S000004332RPP0YLR340WverifiedConserved ribosomal protein P0 similar to rat P0, human P0, andE. coli L10e; shown to be phosphorylated onserine 302 0.021090.06655&radic&radic S000001889SEC4YFL005WverifiedSecretory vesicle-associated Rab GTPase essential forexocytosis; associates with the exocystcomponent Sec15p and may regulate polarizeddelivery of transport vesicles to the exocystat the plasma membrane 0.021040.06642 S000004427TSR2YLR435WverifiedProtein with a potential role in pre-rRNA processing 0.021010.0663&radic&radic S000005314SSK2YNR031CverifiedMAP kinase kinase kinase of the HOG1 mitogen-activatedsignaling pathway; interacts with Ssk1p,leading to autophosphorylation and activationof Ssk2p which phosphorylates Pbs2p; alsomediates actin cytoskeleton recovery fromosmotic stress 0.0210.06613&radic S000004577ZDS2YML109WverifiedProtein that interacts with silencing proteins at the telomere,involved in transcriptional silencing; paralogof Zds1p 0.020950.06613&radic S000004170SAM1YLR180WverifiedS-adenosylmethionine synthetase, catalyzes transfer of theadenosyl group of ATP to the sulfur atom ofmethionine; one of two differentially regulatedisozymes (Sam1p and Sam2p) 0.020950.06612&radic&radic&radic&radic S000003288RSC1YGR056WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; containstwo essential bromodomains, a bromo-adjacenthomology (BAH) domain, and an AT hook 0.020930.06606&radic&radic&radic&radic&radic&radic S000005831ISW2YOR304WverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPasecomponent that, with Itc1p, forms a complexrequired for repression of a-specific genes,INO1, and early meiotic genes during mitoticgrowth 0.020940.06606&radic&radic&radic&radic S000002213PSA1YDL055CverifiedGDP-mannose pyrophosphorylase (mannose-1-phosphateguanyltransferase), synthesizes GDP-mannosefrom GTP and mannose-1-phosphate in cell wallbiosynthesis; required for normal cell wallstructure 0.02090.06596&radic S000004294MET17YLR303WverifiedO-acetyl homoserine-O-acetyl serine sulfhydrylase, required forsulfur amino acid synthesis 0.020890.06591&radic&radic&radic&radic S000005750RPB8YOR224CverifiedRNA polymerase subunit ABC14.5, common to RNA polymerases I,II, and III 0.020850.0658&radic&radic&radic&radic S000003095SOH1YGL127CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; involved in telomeremaintenance; conserved with other metazoanMED31 subunits 0.020860.0658&radic S000004065RPL10YLR075WverifiedProtein component of the large (60S) ribosomal subunit,responsible for joining the 40S and 60Ssubunits; regulates translation initiation; hassimilarity to rat L10 ribosomal protein and tomembers of the QM gene family 0.020850.0658&radic&radic&radic&radic S000000263AKL1YBR059CverifiedSer-Thr protein kinase, member (with Ark1p and Prk1p) of theArk kinase family; involved in endocytosis andactin cytoskeleton organization 0.020810.06563&radic S000004966HDA1YNL021WverifiedPutative catalytic subunit of a class II histone deacetylasecomplex that also contains Hda2p and Hda3p;Hda1p interacts with the Hda2p-Hda3p subcomplexto form an active tetramer; deletion increaseshistone H2B, H3 and H4 acetylation 0.020780.06554&radic S000004992SLM2YNL047CverifiedPhosphoinositide PI4,5P(2) binding protein, forms a complexwith Slm1p; acts downstream of Mss4p in apathway regulating actin cytoskeletonorganization in response to stress; subunit ofand phosphorylated by the TORC2 complex 0.020770.06554 S000003651ASF1YJL115WverifiedNucleosome assembly factor, involved in chromatin assembly anddisassembly, anti-silencing protein that causesderepression of silent loci when overexpressed 0.020720.06537&radic S000007273BI4Q0120verifiedMitochondrial mRNA maturase, forms a complex with Nam2p tomediate splicing of the bI4 intron of the COBgene; encoded by both exon and intron sequencesof partially processed COB mRNA 0.020710.06533 S000005779NAT5YOR253WverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.02070.06531&radic&radic&radic&radic&radic S000000745MMS21YEL019CverifiedSUMO ligase involved in chromosomal organization and DNArepair; essential subunit of theMms21-Smc5-Smc6 complex; mutants are sensitiveto methyl methanesulfonate and show increasedspontaneous mutation and mitotic recombination 0.020690.06528&radic&radic&radic&radic&radic S000002160NHP10YDL002CverifiedProtein related to mammalian high mobility group proteins;likely component of the INO80 complex, which isan ATP-dependent chromatin-remodeling complex 0.020690.06528&radic S000001055ARD1YHR013CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.020660.06519&radic&radic&radic&radic&radic&radic S000000970CCA1YER168CverifiedATP (CTP):tRNA-specific tRNA nucleotidyltransferase; differentforms targeted to the nucleus, cytosol, andmitochondrion are generated via the use ofmultiple transcriptional and translationalstart sites &radic0.020640.06512&radic S000000763RAD23YEL037CverifiedProtein with ubiquitin-like N terminus, recognizes and bindsdamaged DNA (with Rad4p) during nucleotideexcision repair; regulates Rad4p levels,subunit of Nuclear Excision Repair Factor 2(NEF2); homolog of human HR23A and HR23Bproteins 0.020590.06494&radic&radic&radic&radic S000000131POL12YBL035CverifiedB subunit of DNA polymerase alpha-primase complex, required forinitiation of DNA replication during mitoticand premeiotic DNA synthesis; also functions intelomere capping and length regulation 0.020630.06494&radic&radic&radic&radic&radic S000000888ILV1YER086WverifiedThreonine deaminase, catalyzes the first step in isoleucinebiosynthesis; expression is under general aminoacid control; ILV1 locus exhibits highlypositioned nucleosomes whose organization isindependent of known ILV1 regulation 0.020570.06491 S000002289LYS21YDL131WverifiedHomocitrate synthase isozyme, catalyzes the condensation ofacetyl-CoA and alpha-ketoglutarate to formhomocitrate, which is the first step in thelysine biosynthesis pathway; highly similar tothe other isozyme, Lys20p 0.020540.06476&radic S000004048SHM2YLR058CverifiedCytosolic serine hydroxymethyltransferase, involved inone-carbon metabolism 0.020540.06476&radic&radic&radic&radic&radic&radic&radic&radic&radic S000004949HRB1YNL004WverifiedPoly(A+) RNA-binding protein, involved in the export of mRNAsfrom the nucleus to the cytoplasm; similar toGbp2p and Npl3p 0.02050.06467&radic S000002506BMH2YDR099Wverified14-3-3 protein, minor isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others 0.02050.0646&radic&radic&radic&radic&radic&radic&radic S000001129YHR087WVerifiedProtein involved in RNA metabolism, one of two yeast homologs (with Sdo1p/Ylr022cp) of the human protein SBDS responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome, also conserved in Archaea 0.020460.06446&radic&radic&radic&radic S000004652ERB1YMR049CverifiedProtein required for maturation of the 25S and 5.8S ribosomalRNAs; constituent of 66S pre-ribosomalparticles; homologous to mammalian Bop1 0.020440.06443&radic S000004837MRE11YMR224CverifiedSubunit of a complex with Rad50p and Xrs2p (RMX complex) thatfunctions in repair of DNA double-strand breaksand in telomere stability, exhibits nucleaseactivity that appears to be required for RMXfunction; widely conserved 0.020430.06441&radic&radic&radic&radic&radic&radic S000000569CHA1YCL064CverifiedCatabolic L-serine (L-threonine) deaminase, catalyzes thedegradation of both L-serine and L-threonine;required to use serine or threonine as the solenitrogen source, transcriptionally induced byserine and threonine 0.020390.06425&radic&radic&radic&radic&radic S000005190VPS75YNL246WverifiedProtein of unknown function involved in vacuolar proteinsorting; detected in the nucleus 0.020390.06425&radic&radic S000006115DDC1YPL194WverifiedDNA damage checkpoint protein, part of a PCNA-like complexrequired for DNA damage response, required forpachytene checkpoint to inhibit cell cycle inresponse to unrepaired recombinationintermediates; potential Cdc28p substrate 0.020350.06411&radic&radic S000006177CLN2YPL256CverifiedG1 cyclin involved in regulation of the cell cycle; activatesCdc28p kinase to promote the G1 to S phasetransition; late G1 specific expression dependson transcription factor complexes, MBF(Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) 0.020280.0638&radic&radic&radic&radic&radic&radic S000003737ECM25YJL201WverifiedNon-essential protein of unknown function; promoter contains aconsensus binding sequence for factor Abf1p 0.020290.0638&radic S000000203YBL107CUncharacterizedHypothetical protein 0.020320.0638&radic S000006238ARP7YPR034WverifiedActin-related protein involved in transcriptional regulation;subunit of the chromatin remodeling Snf/Swicomplex 0.02020.06352&radic S000002435REG1YDR028CverifiedRegulatory subunit of type 1 protein phosphatase Glc7p,involved in negative regulation ofglucose-repressible genes 0.020180.06352&radic S000005405PSK2YOL045WverifiedOne of two (see also PSK1) PAS domain containing S/T proteinkinases; regulates sugar flux and translationin response to an unknown metabolite byphosphorylating Ugp1p and Gsy2p (sugar flux)and Caf20p, Tif11p and Sro9p (translation) 0.020190.06352&radic&radic&radic&radic&radic&radic&radic S000005007MTQ1YNL063WuncharacterizedS-adenosylmethionine-dependent Methyltransferase; methylatestranslational release factor Mrf1p; similar toE.coli PrmC; is not an essential gene 0.020130.0633 S000000602RVS161YCR009CverifiedAmphiphysin-like lipid raft protein; subunit of a complex(Rvs161p-Rvs167p) that regulates polarizationof the actin cytoskeleton, endocytosis, cellpolarity, cell fusion and viability followingstarvation or osmotic stress 0.020110.0631&radic&radic&radic&radic&radic&radic&radic&radic S000006220TIF6YPR016CverifiedConstituent of 66S pre-ribosomal particles, has similarity tohuman translation initiation factor 6 (eIF6);may be involved in the biogenesis and orstability of 60S ribosomal subunits 0.020.06287&radic S000003233YGR001CUncharacterizedPutative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae 0.019980.06279&radic&radic&radic&radic S000006323CLB2YPR119WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the transition from G2 to Mphase; accumulates during G2 and M, thentargeted via a destruction box motif forubiquitin-mediated degradation by theproteasome 0.019990.06279&radic&radic&radic&radic&radic S000003079NSA1YGL111WverifiedConstituent of 66S pre-ribosomal particles, involved in 60Sribosomal subunit biogenesis 0.019990.06279&radic S000002245LUC7YDL087CverifiedEssential protein associated with the U1 snRNP complex;splicing factor involved in recognition of 5'splice site 0.019960.06273&radic S000006141RPL1AYPL220WverifiedN-terminally acetylated protein component of the large (60S)ribosomal subunit, nearly identical to Rpl1Bpand has similarity to E. coli L1 and rat L10aribosomal proteins; rpl1a rpl1b double nullmutation is lethal 0.019950.06265&radic&radic&radic&radic S000003058LIF1YGL090WverifiedProtein involved in DNA double-strand break repair; physicallyinteracts with DNA ligase 4 (Lig4p); homologousto mammalian XRCC4 protein 0.019940.06265&radic&radic&radic&radic&radic&radic&radic&radic S000001022ECM29YHL030WverifiedMajor component of the proteasome; tethers the proteasome coreparticle to the regulatory particle, andenhances the stability of the proteasome 0.019940.06265&radic&radic&radic S000005552BUB3YOR026WverifiedKinetochore checkpoint WD40 repeat protein that localizes tokinetochores during prophase and metaphase,delays anaphase in the presence of unattachedkinetochores; forms complexes with Mad1p-Bub1pand with Cdc20p, binds Mad2p and Mad3p 0.019850.0624&radic&radic&radic&radic&radic&radic&radic&radic S000000827GCD11YER025WverifiedGamma subunit of the translation initiation factor eIF2,involved in the identification of the startcodon; binds GTP when forming the ternarycomplex with GTP and tRNAi-Met 0.019830.06232&radic&radic S000006260TFB4YPR056WverifiedSubunit of TFIIH complex, involved in transcription initiation,similar to 34 kDa subunit of human TFIIH;interacts with Ssl1p 0.019790.06214&radic S000000286UBC4YBR082CverifiedUbiquitin-conjugating enzyme that mediates degradation ofshort-lived and abnormal proteins; interactswith E3-CaM in ubiquitinating calmodulin;interacts with many SCF ubiquitin proteinligases; component of the cellular stressresponse 0.019730.062&radic&radic S000003464NAS6YGR232WverifiedRegulatory, non-ATPase subunit of the 26S proteasome; homologof the human oncoprotein gankyrin, whichinteracts with the retinoblastoma tumorsuppressor (Rb) and cyclin-dependent kinase 4/6 0.01970.06191&radic&radic&radic&radic&radic&radic&radic&radic S000001564TEF4YKL081WverifiedTranslation elongation factor EF-1 gamma 0.01970.06191&radic&radic&radic&radic&radic&radic S000003945HIF1YLL022CverifiedNon-essential component of the HAT-B histone acetyltransferasecomplex (Hat1p-Hat2p-Hif1p), localized to thenucleus; has a role in telomeric silencing 0.019660.0617&radic S000001224SVP26YHR181WverifiedIntegral membrane protein of the early Golgi apparatus andendoplasmic reticulum, involved in COP IIvesicle transport; may also function to promoteretention of proteins in the early Golgicompartment 0.019650.0617 S000004595ERG13YML126Cverified3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzesthe formation of HMG-CoA from acetyl-CoA andacetoacetyl-CoA; involved in the second step inmevalonate biosynthesis 0.019620.06161&radic S000000141COR1YBL045CverifiedCore subunit of the ubiquinol-cytochrome c reductase complex(bc1 complex), which is a component of themitochondrial inner membrane electron transportchain 0.019620.06161 S000002207KNH1YDL049CverifiedProtein with similarity to Kre9p, which is involved in cellwall beta 1,6-glucan synthesis; overproductionsuppresses growth defects of a kre9 null mutant 0.019610.06161 S000004816TOM40YMR203WverifiedComponent of the TOM (translocase of outer membrane) complexresponsible for recognition and initial importsteps for all mitochondrially directedproteins; constitutes the core element of theprotein conducting pore 0.01960.0616&radic&radic&radic&radic&radic S000000364CDC28YBR160WverifiedCatalytic subunit of the main cell cycle cyclin-dependentkinase (CDK); alternately associates with G1cyclins (CLNs) and G2/M cyclins (CLBs) whichdirect the CDK to specific substrates 0.019590.06155&radic&radic S000001323SNP1YIL061CverifiedComponent of U1 snRNP required for mRNA splicing viaspliceosome; may interact with poly(A)polymerase to regulate polyadenylation; homologof human U1 70K protein 0.019590.06155&radic&radic S000005943RAD1YPL022WverifiedSingle-stranded DNA endonuclease (with Rad10p), cleavessingle-stranded DNA during nucleotide excisionrepair and double-strand break repair; subunitof Nucleotide Excision Repair Factor 1 (NEF1);homolog of human XPF protein 0.019560.06144&radic&radic&radic&radic&radic&radic S000000479RIF1YBR275CverifiedProtein that binds to the Rap1p C-terminus and actssynergistically with Rif2p to help controltelomere length and establish telomericsilencing; deletion results in telomereelongation 0.019510.0613&radic S000002601YDR193WDubiousHypothetical protein 0.019510.06123&radic&radic&radic&radic&radic&radic S000004725ASI1YMR119WverifiedPutative integral membrane E3 ubiquitin ligase; acts with Asi2pand Asi3p to ensure the fidelity of SPS-sensorsignalling by maintaining the dormant repressedstate of gene expression in the absence ofinducing signals 0.019470.0611 S000003888RSF2YJR127CverifiedZinc-finger protein involved in transcriptional control of bothnuclear and mitochondrial genes, many of whichspecify products required for glycerol-basedgrowth, respiration, and other functions 0.019460.0611&radic S000001493UFD4YKL010CverifiedUbiquitin-protein ligase (E3) that interacts with Rpt4p andRpt6p, two subunits of the 19S particle of the26S proteasome; cytoplasmic E3 involved in thedegradation of ubiquitin fusion proteins 0.019470.0611&radic&radic&radic&radic&radic&radic&radic S000004953ASI3YNL008CverifiedPutative integral membrane E3 ubiquitin ligase; acts with Asi1pand Asi2p to ensure the fidelity of SPS-sensorsignalling by maintaining the dormant repressedstate of gene expression in the absence ofinducing signals 0.019460.0611 S000004072SRL2YLR082CverifiedProtein of unknown function; overexpression suppresses thelethality caused by a rad53 null mutation 0.019440.06101&radic&radic&radic&radic S000002603REF2YDR195WverifiedRNA-binding protein involved in the cleavage step of mRNA3'-end formation prior to polyadenylation, andin snoRNA maturation; part of holo-CPFsubcomplex APT, which associates with 3'-endsof snoRNA- and mRNA-encoding genes 0.019410.06089&radic&radic&radic&radic&radic&radic S000003627GWT1YJL091CverifiedProtein involved in the inositol acylation of glucosaminylphosphatidylinositol (GlcN-PI) to formglucosaminyl(acyl)phosphatidylinositol(GlcN(acyl)PI), an intermediate in thebiosynthesis of glycosylphosphatidylinositol(GPI) anchors 0.01940.06089 S000003074MLC1YGL106WverifiedEssential light chain for myosin Myo2p; may stabilize Myo2p bybinding to the neck region; may interact withMyo1p, Iqg1p, and Myo2p to coordinate formationand contraction of the actomyosin ring withtargeted membrane deposition 0.019430.06089 S000004349RSC2YLR357WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; involvedin telomere maintenance 0.019380.06083&radic&radic&radic&radic&radic S000003781YJR020WDubiousHypothetical protein 0.019350.06071 S000002178RPN4YDL020CverifiedTranscription factor that stimulates expression of proteasomegenes; Rpn4p levels are in turn regulated bythe 26S proteasome in a negative feedbackcontrol mechanism; RPN4 is transcriptionallyregulated by various stress responses 0.019370.06071&radic&radic S000003584UBX6YJL048CuncharacterizedUBX (ubiquitin regulatory X) domain-containing protein thatinteracts with Cdc48p, transcription isrepressed when cells are grown in mediacontaining inositol and choline 0.019330.06059 S000004564TAF13YML098WverifiedTFIID subunit (19 kDa), involved in RNA polymerase IItranscription initiation, similar to histone H4with atypical histone fold motif of Spt3-liketranscription factors 0.019330.06059&radic&radic S000002688RRP45YDR280WverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex 0.019340.06059&radic&radic&radic S000000101PDR3YBL005WverifiedTranscriptional activator of the pleiotropic drug resistancenetwork, regulates expression of ATP-bindingcassette (ABC) transporters through binding tocis-acting sites known as PDREs (PDR responsiveelements) 0.019290.06044&radic&radic S000006062YPL141CUncharacterizedHypothetical protein 0.019270.06044&radic&radic S000003622YJL086CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1 0.019230.06034 S000006378YPR174CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate 0.019190.06018&radic S000005022NIS1YNL078WverifiedProtein localized in the bud neck at G2/M phase; physicallyinteracts with septins; possibly involved in amitotic signaling network 0.019150.06007 S000004705YMR099CVerifiedGlucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to the nucleus and cytoplasm; mutants show increased resistance to fluconazole 0.019140.06004&radic&radic S000005667ARP8YOR141CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes 0.01910.05991&radic&radic&radic S000002635SIR4YDR227WverifiedSilent information regulator that, together with SIR2 and SIR3,is involved in assembly of silent chromatindomains at telomeres and the silent mating-typeloci; potentially phosphorylated by Cdc28p;some alleles of SIR4 prolong lifespan 0.01910.05987&radic&radic&radic&radic S000002718SUM1YDR310CverifiedTranscriptional repressor required for mitotic repression ofmiddle sporulation-specific genes; involved intelomere maintenance, regulated by thepachytene checkpoint 0.019070.05982&radic&radic&radic&radic&radic S000005098YCK2YNL154CverifiedPalmitoylated, plasma membrane-bound casein kinase I isoform;shares redundant functions with Yck1p inmorphogenesis, proper septin assembly,endocytic trafficking; provides an essentialfunction overlapping with that of Yck1p 0.019050.05971&radic&radic&radic&radic&radic&radic&radic S000004641CCS1YMR038CverifiedCopper chaperone for superoxide dismutase Sod1p, involved inoxidative stress protection; Met-X-Cys-X2-Cysmotif within the N-terminal portion is involvedin insertion of copper into Sod1p underconditions of copper deprivation 0.018990.05954&radic&radic&radic&radic&radic&radic&radic S000001073RRM3YHR031CverifiedDNA helicase involved in rDNA replication and Ty1transposition; relieves replication fork pausesat telomeric regions; structurally andfunctionally related to Pif1p 0.018990.05954&radic&radic&radic&radic&radic&radic S000003992NOC3YLR002CverifiedProtein that forms a nuclear complex with Noc2p that binds to66S ribosomal precursors to mediate theirintranuclear transport; also binds to chromatinto promote the association of DNA replicationfactors and replication initiation 0.018950.0594&radic&radic&radic&radic S000005713TUF1YOR187WverifiedMitochondrial translation elongation factor Tu; comprises bothGTPase and guanine nucleotide exchange factoractivities, while these activities are found inseparate proteins in S. pombe and humans 0.018960.0594&radic&radic&radic&radic S000000456DUT1YBR252WverifieddUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, therebypreventing in