Yfunc lets you browse current and predicted gene functions in yeast

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Prediction of GO:0006402 "mRNA catabolism"

GO branch: BP
Number of currently annotated genes: 59

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest TAP:128Huh:nucleusHuh:cytoplasmHuh:nucleolusLum:ChlorpromazineKumar:nucleusLum:5-FULum:MetoclopramideTAP:142Lum:Carbendazim S000003427SKI6YGR195Wverified3'-to-5' phosphorolytic exoribonuclease that is a subunit ofthe exosome; required for 3' processing of the5.8S rRNA; involved in 3' to 5' mRNAdegradation and translation inhibition ofnon-poly(A) mRNAs &radic0.692070.9589&radic&radic&radic&radic&radic&radic&radic S000005091LSM7YNL147WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA &radic0.668870.9589&radic&radic&radic S000001300NOT3YIL038CverifiedSubunit of the CCR4-NOT complex, which is a globaltranscriptional regulator with roles intranscription initiation and elongation and inmRNA degradation &radic0.640790.95673&radic S000006434LSM3YLR438C-AverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA &radic0.639160.95673&radic&radic&radic S000003660LSM1YJL124CverifiedLsm (Like Sm) protein; forms heteroheptameric complex (withLsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p)involved in degradation of cytoplasmic mRNAs &radic0.611950.95031&radic&radic&radic S000000948LSM5YER146WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA &radic0.608760.95014&radic&radic S000001111RRP4YHR069CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp41p, Rrp42p,Rrp43p and Dis3p &radic0.596610.94793&radic&radic&radic&radic&radic&radic&radic&radic S000006276NOT5YPR072WverifiedSubunit of the CCR4-NOT complex, which is a globaltranscriptional regulator with roles intranscription initiation and elongation and inmRNA degradation &radic0.596790.94793&radic S000005527RRP6YOR001WverifiedExonuclease component of the nuclear exosome; contributes tothe quality-control system that retains anddegrades aberrant mRNAs in the nucleus &radic0.589590.94793&radic&radic&radic&radic&radic&radic&radic S000000122LSM2YBL026WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA &radic0.565460.92739&radic&radic&radic&radic&radic S000004390SKI2YLR398CverifiedPutative RNA helicase, involved in exosome mediated 3' to 5'mRNA degradation and translation inhibition ofnon-poly(A) mRNAs; forms complex with Ski3p andSki8p; required for repressing propagation ofdsRNA viruses &radic0.552760.91942&radic&radic&radic&radic&radic S000003783LSM8YJR022WverifiedLsm (Like Sm) protein; forms heteroheptameric complex (withLsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p)that is part of spliceosomal U6 snRNP and isalso implicated in processing of pre-tRNA,pre-snoRNA, and pre-rRNA 0.552630.91845&radic&radic&radic S000005381DIS3YOL021CverifiedNucleolar exosome component, involved in rRNA processing andRNA degradation, binds Gsp1p/Ran and enhancesthe GEF activity of Srm1p, implicated inmitotic control, homologous to the E. coliRNase R of the RNase II family &radic0.541790.91009&radic&radic&radic&radic&radic&radic&radic&radic S000002688RRP45YDR280WverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex &radic0.516620.89725&radic&radic&radic&radic&radic&radic S000005509DCP1YOL149WverifiedSubunit of the Dcp1p-Dcp2p decapping enzyme complex, whichremoves the 5' cap structure from mRNAs priorto their degradation; enhances the activity ofcatalytic subunit Dcp2p; regulated by DEAD boxprotein Dhh1p &radic0.49690.88749 S000005062DCP2YNL118CverifiedCatalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex,which removes the 5' cap structure from mRNAsprior to their degradation; member of the Nudixhydrolase family &radic0.491190.8863&radic&radic S000004265SMD2YLR275WverifiedCore Sm protein Sm D2; part of heteroheptameric complex (withSmb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D2 0.491580.8863&radic&radic&radic&radic&radic S000006393SKI3YPR189WverifiedProtein involved in exosome mediated 3' to 5' mRNA degradationand translation inhibition of non-poly(A)mRNAs; forms complex with Ski2p and Ski8p;required for repressing propagation of dsRNAviruses &radic0.478480.88363&radic&radic&radic S000002786LSM6YDR378CverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA &radic0.485640.88363&radic&radic&radic&radic&radic S000001123LRP1YHR081WverifiedSubstrate-specific nuclear cofactor for exosome activity in theprocessing of stable RNAs; required fortelomere length maintenance; homolog ofmammalian nuclear matrix protein C1D involvedin regulation of DNA repair and recombination &radic0.474040.88285&radic&radic&radic&radic&radic S000000914LSM4YER112WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA &radic0.470610.88194&radic&radic&radic&radic S000005602SKI7YOR076CverifiedAntiviral adaptor protein that mediates interactions via itsN-terminus between the exosome and Ski complex(Ski2p, Ski3p, Ski8p) which operate in the3'-to-5' mRNA-decay pathway; cytoplasmicprotein required for degrading nonstop mRNAs &radic0.463030.87986&radic&radic&radic S000000831SMB1YER029CverifiedCore Sm protein Sm B; part of heteroheptameric complex (withSmd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm B and Sm B' 0.460520.87846&radic&radic S000002324CDC36YDL165WverifiedComponent of the CCR4-NOT complex, which has multiple roles inregulating mRNA levels including regulation oftranscription and destabilizing mRNAs bydeadenylation; basal transcription factor &radic0.455380.87254&radic S000003390MTR3YGR158Cverified3'5' exoribonuclease, exosome subunit; nucleolar proteininvolved in export of mRNA and ribosomalsubunits; homologous to the E. coli exonucleaseRNase PH &radic0.450130.86919&radic&radic&radic&radic&radic&radic&radic S000002269RRP42YDL111CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp4p, Rrp41p,Rrp43p and Dis3p &radic0.428520.86019&radic&radic&radic&radic S000000631RRP43YCR035CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp41p, Rrp42p,Rrp4p and Dis3p; required for efficientmaturation of 5.8S, 18S and 25S rRNA &radic0.414850.8494&radic&radic&radic S000003327RRP46YGR095CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex &radic0.401130.84184&radic&radic&radic&radic&radic&radic&radic S000003394TIF4631YGR162WverifiedTranslation initiation factor eIF4G, subunit of the mRNAcap-binding protein complex (eIF4F) that alsocontains eIF4E (Cdc33p); associates with thepoly(A)-binding protein Pab1p, also interactswith eIF4A (Tif1p); homologous to Tif4632p 0.400350.84152&radic S000000741EDC3YEL015WverifiedNon-essential conserved protein of unknown function, plays arole in mRNA decapping by specificallyaffecting the function of the decapping enzymeDcp1p; localizes to cytoplasmic mRNA processingbodies &radic0.331180.78565&radic&radic&radic S000003146MPT5YGL178WverifiedMember of the Puf family of RNA-binding proteins; binds tomRNAs encoding chromatin modifiers and spindlepole body components; involved in longevity,maintenance of cell wall integrity, andsensitivity to and recovery from pheromonearrest &radic0.330010.78426&radic S000005176CSL4YNL232WverifiedSubunit of the exosome, which is an essential complex presentin both nucleus and cytoplasm that mediates RNAprocessing and degradation &radic0.326330.78061&radic&radic&radic&radic&radic&radic&radic S000005335POP2YNR052CverifiedRNase of the DEDD superfamily, subunit of the Ccr4-Not complexthat mediates 3' to 5' mRNA deadenylation &radic0.297320.7584&radic&radic S000003017TIF4632YGL049CverifiedTranslation initiation factor eIF4G, subunit of the mRNAcap-binding protein complex (eIF4F) that alsocontains eIF4E (Cdc33p); associates with thepoly(A)-binding protein Pab1p, also interactswith eIF4A (Tif1p); homologous to Tif4631p 0.28810.74958&radic&radic&radic S000000019CCR4YAL021CverifiedComponent of the CCR4-NOT transcriptional complex, which isinvolved in regulation of gene expression;component of the major cytoplasmic deadenylase,which is involved in mRNA poly(A) tailshortening &radic0.287360.7494&radic&radic&radic S000002319DHH1YDL160CverifiedCytoplasmic DExD/H-box helicase, stimulates mRNA decapping,coordinates distinct steps in mRNA function anddecay, interacts with both the decapping anddeadenylase complexes, may have a role in mRNAexport and translation &radic0.28650.74798&radic&radic&radic S000003322UTP22YGR090WuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.277550.74019&radic&radic&radic&radic&radic&radic&radic S000000100UTP20YBL004WverifiedComponent of the small-subunit (SSU) processome, which isinvolved in the biogenesis of the 18S rRNA 0.262280.72462&radic&radic&radic&radic S000005195NRD1YNL251CverifiedRNA-binding protein that interacts with the C-terminal domainof the RNA polymerase II large subunit(Rpo21p), required for transcriptiontermination and 3' end maturation ofnonpolyadenylated RNAs 0.237970.6967&radic&radic&radic&radic&radic S000002982PUF4YGL014WverifiedMember of the PUF protein family, which is defined by thepresence of Pumilio homology domains thatconfer RNA binding activity; preferentiallybinds mRNAs encoding nucleolar ribosomalRNA-processing factors &radic0.237470.6966&radic S000000689CDC39YCR093WverifiedComponent of the CCR4-NOT complex, which has multiple roles inregulating mRNA levels including regulation oftranscription and destabilizing mRNAs bydeadenylation; basal transcription factor &radic0.237580.6966&radic&radic&radic S000003645UTP10YJL109CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.233370.69172&radic&radic S000004735ECM16YMR128WverifiedEssential DEAH-box ATP-dependent RNA helicase specific to theU3 snoRNP, predominantly nucleolar indistribution, required for 18S rRNA synthesis 0.230790.6892&radic&radic&radic S000001119NMD2YHR077CverifiedProtein involved in the nonsense-mediated mRNA decay (NMD)pathway; interacts with Nam7p and Upf3p;involved in telomere maintenance &radic0.230130.68893&radic&radic&radic&radic S000005502RRP40YOL142WverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex &radic0.225780.68595&radic&radic&radic S000002965SMX2YFL017W-AverifiedCore Sm protein Sm G; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm G 0.224050.68362&radic S000002840NPL3YDR432WverifiedRNA-binding protein that carries poly(A)+ mRNA from the nucleusinto the cytoplasm; phosphorylation by Sky1p inthe cytoplasm may promote release of mRNAs 0.216060.67223&radic&radic&radic S000000870MOT2YER068WverifiedComponent of the CCR4-NOT complex, which has multiple roles intranscription regulation, mRNA degradation, andpost-transcriptional modifications; with Ubc4p,ubiquitylates subunits of the nascentpolypeptide-associated complex (NAC) &radic0.200890.65098&radic&radic&radic S000003586MTR4YJL050WverifiedDead-box family ATP dependent helicase required for mRNA exportfrom the nucleus; co-factor of the exosomecomplex, required for 3' end formation of 5.8SrRNA 0.195990.6453&radic&radic S000004842RRP5YMR229CverifiedProtein required for the synthesis of both 18S and 5.8S rRNA;C-terminal region is crucial for the formationof 18S rRNA and N-terminal region is requiredfor the 5.8S rRNA; component of small ribosomalsubunit (SSU) processosome 0.1940.64222&radic&radic&radic S000004137SMD3YLR147CverifiedCore Sm protein Sm D3; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D3 0.19380.64217&radic S000004556RPM2YML091CverifiedProtein component of mitochondrial RNase P, along with themitochondrially-encoded RNA subunit RPM1; RnaseP removes 5' extensions from tRNA precursors;Rpm2p is also involved in maturation of RPM1and in translation of mitochondrial mRNAs 0.176730.61873 S000001474YIR035CUncharacterizedHypothetical protein 0.17640.61848&radic&radic&radic S000005232CAF40YNL288WverifiedEvolutionarily conserved subunit of the CCR4-NOT complexinvolved in controlling mRNA initiation,elongation and degradation; binds Cdc39p 0.174790.61658&radic&radic S000004685NAM7YMR080CverifiedATP-dependent RNA helicase of the SFI superfamily, required fornonsense mediated mRNA decay and for efficienttranslation termination at nonsense codons;involved in telomere maintenance &radic0.170850.61045&radic&radic S000002701SSD1YDR293CverifiedProtein with a role in maintenance of cellular integrity,interacts with components of the TOR pathway;ssd1 mutant of a clinical S. cerevisiae straindisplays elevated virulence 0.162870.5966&radic&radic&radic&radic&radic S000002789YRA1YDR381WverifiedNuclear protein that binds to RNA and to Mex67p, required forexport of poly(A)+ mRNA from the nucleus;member of the REF (RNA and export factorbinding proteins) family; another familymember, Yra2p, can substitute for Yra1pfunction 0.160960.59495&radic&radic&radic&radic&radic S000004260DCS1YLR270WverifiedNon-essential hydrolase involved in mRNA decapping, mayfunction in a feedback mechanism to regulatedeadenylation, contains pyrophosphataseactivity and a HIT (histidine triad) motif;interacts with neutral trehalase Nth1p &radic0.149220.57585&radic&radic&radic&radic&radic&radic S000006382PRP4YPR178WverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.141790.56515&radic&radic&radic&radic&radic&radic S000003851JSN1YJR091CverifiedMember of the Puf family of RNA-binding proteins, interactswith mRNAs encoding membrane-associatedproteins; overexpression suppresses a tub2-150mutation and causes increased sensitivity tobenomyl in wild-type cells &radic0.140220.56277 S000005853MYO2YOR326WverifiedOne of two type V myosin motors (along with MYO4) involved inactin-based transport of cargos; required forthe polarized delivery of secretory vesicles,the vacuole, late Golgi elements, peroxisomes,and the mitotic spindle 0.130630.54765&radic&radic&radic S000003306SMD1YGR074WverifiedCore Sm protein Sm D1; part of heteroheptameric complex (withSmb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D1 0.126130.54018&radic&radic&radic&radic S000003510CWC22YGR278WverifiedEssential protein, component of a complex containing Cef1p, hassimilarity to S. pombe Cwf22p; putativespliceosomal component, based on computationalanalysis of large-scale protein-proteininteraction data 0.123460.53196&radic&radic&radic&radic S000005699DCS2YOR173WverifiedNon-essential, stress induced regulatory protein containing aHIT (histidine triad) motif; modulatesm7G-oligoribonucleotide metabolism; inhibitsDcs1p; regulated by Msn2p, Msn4p, and theRas-cAMP-cAPK signaling pathway, similar toDcs1p. &radic0.122430.53062&radic&radic&radic&radic S000004881PRP24YMR268CverifiedSplicing factor that reanneals U4 and U6 snRNPs duringspliceosome recycling 0.116190.51687&radic&radic&radic&radic&radic&radic S000005499CDC33YOL139CverifiedCytoplasmic mRNA cap binding protein; the eIF4E-cap complex isresponsible for mediating cap-dependent mRNAtranslation via interactions with thetranslation initiation factor eIF4G (Tif4631por Tif4632p) &radic0.114210.5122&radic&radic S000002209LHP1YDL051WverifiedRNA binding protein required for maturation of tRNA and snRNAprecursors; acts as a molecular chaperone forRNAs transcribed by polymerase III; homologousto human La (SS-B) autoantigen 0.102980.48912&radic S000004732STO1YMR125WverifiedLarge subunit of the nuclear mRNA cap-binding protein complex,interacts with Npl3p to carry nuclear poly(A)+mRNA to cytoplasm; also involved in nuclearmRNA degradation and telomere maintenance;orthologous to mammalian CBP80 &radic0.099640.481&radic&radic S000002904PUF6YDR496CverifiedPumilio-homology domain protein that binds ASH1 mRNA at PUFconsensus sequences in the 3' UTR and repressesits translation, resulting in proper asymmetriclocalization of ASH1 mRNA 0.098520.47802&radic&radic S000001557MUD2YKL074CverifiedProtein involved in early pre-mRNA splicing; component of thepre-mRNA-U1 snRNP complex, the commitmentcomplex; interacts with Msl5p/BBP splicingfactor and Sub2p; similar to metazoan splicingfactor U2AF65 0.098340.4776&radic&radic&radic&radic S000000323MUD1YBR119WverifiedU1 snRNP A protein, homolog of human U1-A; involved in nuclearmRNA splicing 0.095840.47054&radic&radic S000003936PUF3YLL013CverifiedProtein that regulates degradation of specific mRNAs such asCOX17, binds almost exclusively to cytoplasmicmRNAs encoding mitochondrial proteins, memberof the PUF protein family that contains Pumiliohomology domains &radic0.095230.46934&radic&radic S000006246PUF2YPR042CverifiedMember of the PUF protein family, which is defined by thepresence of Pumilio homology domains thatconfer RNA binding activity; preferentiallybinds mRNAs encoding membrane-associatedproteins &radic0.093730.46622&radic S000000103SLA1YBL007CverifiedCytoskeletal protein binding protein required for assembly ofthe cortical actin cytoskeleton; contains 3 SH3domains; interacts with proteins regulatingactin dynamics and with proteins required forendocytosis 0.093270.46518&radic&radic&radic&radic S000003088PRP43YGL120CverifiedRNA helicase in the DEAH-box family, functions in both RNApolymerase I and polymerase II transcriptmetabolism, involved in release of thelariat-intron from the spliceosome 0.09310.46481&radic&radic S000000542SRO9YCL037CverifiedCytoplasmic RNA-binding protein that associates withtranslating ribosomes; involved in hemeregulation of Hap1p as a component of the HMCcomplex, also involved in the organization ofactin filaments; contains a La motif 0.092420.46258&radic&radic&radic S000004170SAM1YLR180WverifiedS-adenosylmethionine synthetase, catalyzes transfer of theadenosyl group of ATP to the sulfur atom ofmethionine; one of two differentially regulatedisozymes (Sam1p and Sam2p) 0.088540.45104&radic&radic&radic&radic S000004722ASC1YMR116CverifiedWD repeat protein (G-beta like protein) involved in translationregulation; required for repression of Gcn4pactivity in the absence of amino-acidstarvation; core component of the ribosome;ortholog of mammalian RACK1 0.08810.45015&radic S000002344TFP1YDL185WverifiedVacuolar ATPase V1 domain subunit A containing the catalyticnucleotide binding sites; protein precursorundergoes self-catalyzed splicing to yield theextein Tfp1p and the intein Vde (PI-SceI),which is a site-specific endonuclease 0.088030.44983 S000006284TEF1YPR080WverifiedTranslational elongation factor EF-1 alpha; also encoded byTEF2; functions in the binding reaction ofaminoacyl-tRNA (AA-tRNA) to ribosomes 0.083570.43604&radic S000002812RPB7YDR404CverifiedRNA polymerase II subunit B16; forms two subunit dissociablecomplex with Rpb4p 0.083250.43493&radic&radic&radic S000004802SGS1YMR190CverifiedNucleolar DNA helicase of the RecQ family involved inmaintenance of genome integrity, regulateschromosome synapsis and meiotic crossing over;has similarity to human BLM and WRN helicasesimplicated in Bloom and Werner syndromes 0.082830.43358&radic&radic&radic&radic&radic S000006111NAB3YPL190CverifiedSingle stranded DNA binding protein; acidic ribonucleoprotein;required for termination of non-poly(A)transcripts and efficient splicing; interactswith Nrd1p 0.082280.43169&radic&radic&radic&radic S000002256SNU23YDL098CverifiedComponent of U4/U6.U5 snRNP involved in mRNA splicing viaspliceosome 0.081790.42953&radic&radic&radic S000003674TIF2YJL138CverifiedTranslation initiation factor eIF4A, identical to Tif1p;DEA(D/H)-box RNA helicase that couples ATPaseactivity to RNA binding and unwinding; forms adumbbell structure of two compact domainsconnected by a linker; interacts with eIF4G 0.081550.42897&radic&radic&radic S000000974BRR2YER172CverifiedRNA-dependent ATPase RNA helicase involved in the facilitationand disruption of snRNA interactions, requiredfor disruption of U4/U6 base-pairing in nativesnRNPs to activate the spliceosome forcatalysis 0.079850.4238&radic&radic&radic S000004585NAB6YML117WuncharacterizedPutative RNA-binding protein, based on computational analysisof large-scale protein-protein interaction data 0.077550.41696&radic S000000967PAB1YER165WverifiedPoly(A) binding protein, part of the 3'-end RNA-processingcomplex, mediates interactions between the 5'cap structure and the 3' mRNA poly(A) tail,involved in control of poly(A) tail length,interacts with translation factor eIF-4G 0.076740.41489&radic&radic S000005685SME1YOR159CverifiedCore Sm protein Sm E; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm E 0.076090.41282&radic&radic&radic&radic S000003899IML1YJR138WverifiedProtein of unknown function, green fluorescent protein(GFP)-fusion protein localizes to the vacuolarmembrane 0.075940.41229 S000004153MAS1YLR163CverifiedSmaller subunit of the mitochondrial processing protease (MPP),essential processing enzyme that cleaves theN-terminal targeting sequences frommitochondrially imported proteins 0.075790.4118&radic&radic S000001440SGN1YIR001CverifiedCytoplasmic RNA-binding protein, contains an RNA recognitionmotif (RRM); may have a role in mRNAtranslation, as suggested by geneticinteractions with genes encoding proteinsinvolved in translational initiation 0.075480.41038&radic&radic S000002172NOP1YDL014WverifiedNucleolar protein, component of the small subunit processomecomplex, which is required for processing ofpre-18S rRNA; has similarity to mammalianfibrillarin 0.074930.40874&radic S000006286DIB1YPR082Cverified17-kDa component of the U4/U6aU5 tri-snRNP, plays an essentialrole in pre-mRNA splicing, orthologue of hDIM1,the human U5-specific 15-kDa protein 0.074620.4073&radic S000001026SBP1YHL034CverifiedNucleolar single-strand nucleic acid binding protein;associates with small nuclear RNAs 0.074620.4073&radic&radic&radic&radic S000000614MAK31YCR020C-AverifiedNon-catalytic subunit of N-terminal acetyltransferase of theNatC type; required for replication of dsRNAvirus; member of the Sm protein family 0.07260.40128&radic&radic S000003366CAF130YGR134WverifiedPart of the evolutionarily-conserved CCR4-NOT transcriptionalregulatory complex involved in controlling mRNAinitiation, elongation, and degradation 0.072460.40085&radic S000004470SPT5YML010WverifiedProtein that forms a complex with Spt4p and mediates bothactivation and inhibition of transcriptionelongation; Spt4p-Spt5p complex also plays arole in pre-mRNA processing 0.071760.39913&radic&radic&radic&radic S000005206POL2YNL262WverifiedCatalytic subunit of DNA polymerase epsilon, one of the majorchromosomal DNA replication polymerasescharacterized by processivity and proofreadingexonuclease activity; also involved in DNAsynthesis during DNA repair 0.071390.39748&radic&radic&radic&radic&radic S000000259PRP6YBR055CverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.06990.3926&radic&radic&radic S000005259ATP11YNL315CverifiedMolecular chaperone, required for the assembly of alpha andbeta subunits into the F1 sector ofmitochondrial F1F0 ATP synthase 0.069380.39075 S000000813TIR1YER011WverifiedCell wall mannoprotein of the Srp1p/Tip1p family ofserine-alanine-rich proteins; expression isdownregulated at acidic pH and induced by coldshock and anaerobiosis; abundance is increasedin cells cultured without shaking 0.0690.3896&radic&radic&radic S000003547NOP9YJL010CuncharacterizedEssential nucleolar protein required for 18S rRNA synthesis 0.067870.38524&radic&radic S000002326NRP1YDL167CverifiedProtein of unknown function, rich in asparagine residues 0.067280.38237&radic S000004593TUB3YML124CverifiedAlpha-tubulin; associates with beta-tubulin (Tub2p) to formtubulin dimer, which polymerizes to formmicrotubules; expressed at lower level thanTub1p 0.067220.38214&radic&radic S000000346MAK5YBR142WverifiedEssential nucleolar protein, putative DEAD-box RNA helicaserequired for maintenance of M1 dsRNA virus;involved in biogenesis of large (60S) ribosomalsubunits 0.067140.38171&radic&radic S000006099CBC2YPL178WverifiedSmall subunit of the heterodimeric cap binding complex thatalso contains Sto1p, component of thespliceosomal commitment complex; interacts withNpl3p, possibly to package mRNA for export fromthe nucleus; contains an RNA-binding motif 0.066980.38145&radic&radic&radic&radic S000002242SUB2YDL084WverifiedComponent of the TREX complex required for nuclear mRNA export;member of the DEAD-box RNA helicase superfamilyand is involved in early and late steps ofspliceosome assembly; homolog of the humansplicing factor hUAP56 0.066930.38128&radic&radic S000001128NAM8YHR086WverifiedRNA binding protein, component of the U1 snRNP protein; mutantsare defective in meiotic recombination and information of viable spores, involved in theformation of DSBs through meiosis-specificsplicing of MER2 pre-mRNA 0.066860.38115&radic&radic&radic&radic S000002545HPR1YDR138WverifiedSubunit of THO/TREX complexes that couple transcriptionelongation with mitotic recombination and withmRNA metabolism and export, subunit of an RNAPol II complex; regulates lifespan; involved intelomere maintenance; similar to Top1p 0.066050.37838&radic&radic&radic&radic S000000808NUG1YER006WverifiedGTPase that associates with nuclear 60S pre-ribosomes, requiredfor export of 60S ribosomal subunits from thenucleus 0.064940.37511&radic&radic&radic&radic&radic&radic S000006386SMX3YPR182WverifiedCore Sm protein Sm F; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm F 0.062250.36667&radic&radic S000003105SEC27YGL137WverifiedEssential beta'-coat protein of the COPI coatomer, involved inER-to-Golgi and Golgi-to-ER transport; containsWD40 domains that mediate cargo selectiveinteractions; 45% sequence identity tomammalian beta'-COP 0.061830.365 S000003181SKI8YGL213CverifiedProtein involved in exosome mediated 3' to 5' mRNA degradationand translation inhibition of non-poly(A) mRNAsas well as double-strand break formation duringmeiotic recombination; required for repressingpropagation of dsRNA viruses &radic0.061460.36367&radic&radic&radic S000000535HIS4YCL030CverifiedMultifunctional enzyme containing phosphoribosyl-ATPpyrophosphatase, phosphoribosyl-AMPcyclohydrolase, and histidinol dehydrogenaseactivities; catalyzes the second, third, ninthand tenth steps in histidine biosynthesis 0.061330.36337&radic&radic&radic S000001656SNU114YKL173WverifiedGTPase component of U5 snRNP involved in mRNA splicing viaspliceosome; binds directly to U5 snRNA;proposed to be involved in conformationalchanges of the spliceosome; similarity toribosomal translocation factor EF-2 0.061140.36294&radic&radic&radic&radic S000003139ROK1YGL171WverifiedATP-dependent RNA helicase of the DEAD box family; required for18S rRNA synthesis 0.061030.36268&radic S000005294PRP2YNR011CverifiedRNA-dependent ATPase in the DEAH-box family, required foractivation of the spliceosome before the firsttransesterification step in RNA splicing 0.06080.36217&radic&radic S000003767SUI2YJR007WverifiedAlpha subunit of the translation initiation factor eIF2,involved in the identification of the startcodon; phosphorylation of Ser51 is required forregulation of translation by inhibiting theexchange of GDP for GTP 0.060490.36098&radic S000003570HCA4YJL033WverifiedPutative nucleolar DEAD box RNA helicase; high-copy numbersuppression of a U14 snoRNA processing mutantsuggests an involvement in 18S rRNA synthesis 0.060320.36088&radic S000000673PAT1YCR077CverifiedTopoisomerase II-associated deadenylation-dependentmRNA-decapping factor; also required forfaithful chromosome transmission, maintenanceof rDNA locus stability, and protection of mRNA3'-UTRs from trimming; functionally linked toPab1p &radic0.059480.35738&radic&radic S000005730DED1YOR204WverifiedATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, requiredfor translation initiation of all yeast mRNAs;mutations in human DEAD-box DBY are a frequentcause of male infertility 0.058530.3541&radic&radic S000002283HNT1YDL125CverifiedAdenosine 5'-monophosphoramidase; interacts physically andgenetically with Kin28p, a CDK and TFIIKsubunit, and genetically with CAK1; member ofthe histidine triad (HIT) superfamily ofnucleotide-binding proteins and similar to Hint 0.057780.35105&radic&radic&radic S000001767TIF1YKR059WverifiedTranslation initiation factor eIF4A, identical to Tif2p;DEA(D/H)-box RNA helicase that couples ATPaseactivity to RNA binding and unwinding; forms adumbbell structure of two compact domainsconnected by a linker; interacts with eIF4G 0.057760.35086&radic&radic&radic&radic&radic S000006040DBP1YPL119CverifiedPutative ATP-dependent RNA helicase of the DEAD-box proteinfamily; mutants show reduced stability of the40S ribosomal subunit scanning through 5'untranslated regions of mRNAs 0.05660.34519&radic&radic&radic S000004165CBF5YLR175WverifiedPseudouridine synthase catalytic subunit of box H/ACA smallnucleolar ribonucleoprotein particles(snoRNPs), acts on both large and small rRNAsand on snRNA U2 0.055170.34023&radic&radic&radic&radic&radic S000004332RPP0YLR340WverifiedConserved ribosomal protein P0 similar to rat P0, human P0, andE. coli L10e; shown to be phosphorylated onserine 302 0.05480.33854&radic&radic S000004034PDC1YLR044CverifiedMajor of three pyruvate decarboxylase isozymes, key enzyme inalcoholic fermentation, decarboxylates pyruvateto acetaldehyde; subject to glucose-, ethanol-,and autoregulation; involved in amino acidcatabolism 0.054550.33785&radic&radic&radic S000002444KRS1YDR037WverifiedLysyl-tRNA synthetase; also identified as a negative regulatorof general control of amino acid biosynthesis 0.053490.33327&radic S000004328SGD1YLR336CverifiedEssential nuclear protein with a possible role in theosmoregulatory glycerol response; interactswith phospholipase C (Plc1p); putative homologof human NOM1 which is implicated in acutemyeloid leukemia 0.052270.32772&radic&radic S000003506TAF1YGR274CverifiedTFIID subunit (145 kDa), involved in RNA polymerase IItranscription initiation, has histoneacetyltransferase activity, involved inpromoter binding and G1/S progression 0.051930.32564&radic&radic&radic&radic&radic S000005816SNF2YOR290CverifiedCatalytic subunit of the SWI/SNF chromatin remodeling complexinvolved in transcriptional regulation;contains DNA-stimulated ATPase activity;functions interdependently in transcriptionalactivation with Snf5p and Snf6p 0.051880.3256&radic&radic&radic&radic S000004140STM1YLR150WverifiedProtein that binds G4 quadruplex and purine motif triplexnucleic acid; acts with Cdc13p to maintaintelomere structure; interacts with ribosomesand subtelomeric Y' DNA; multicopy suppressorof tom1 and pop2 mutations 0.05180.32507&radic&radic&radic&radic S000005937SWI1YPL016WverifiedSubunit of the SWI/SNF chromatin remodeling complex, whichregulates transcription by remodelingchromosomes; required for transcription of manygenes, including ADH1, ADH2, GAL1, HO, INO1 andSUC2 0.050690.31941&radic&radic&radic S000001448MSL1YIR009WverifiedU2B component of U2 snRNP, involved in splicing, binds the U2snRNA stem-loop IV in vitro; does not containthe conserved C-terminal RNA binding domainfound in other family members 0.050530.31864&radic&radic S000005888PRT1YOR361CverifiedSubunit of the core complex of translation initiation factor3(eIF3), essential for translation; part of asubcomplex (Prt1p-Rpg1p-Nip1p) that stimulatesbinding of mRNA and tRNA(i)Met to ribosomes 0.049730.31452&radic&radic&radic S000004107CLF1YLR117CverifiedEssential splicesome assembly factor; contains multipletetratricopeptide repeat (TPR) protein-bindingmotifs and interacts specifically with manyspliceosome components, may serve as a scaffoldduring splicesome assembly 0.049160.31138&radic&radic&radic&radic&radic S000005056DBP2YNL112WverifiedEssential ATP-dependent RNA helicase of the DEAD-box proteinfamily, involved in nonsense-mediated mRNAdecay and rRNA processing &radic0.048930.31101&radic&radic&radic S000006391RPO26YPR187WverifiedRNA polymerase subunit ABC23, common to RNA polymerases I, II,and III; part of central core; similar tobacterial omega subunit 0.048340.30843&radic&radic&radic S000004652ERB1YMR049CverifiedProtein required for maturation of the 25S and 5.8S ribosomalRNAs; constituent of 66S pre-ribosomalparticles; homologous to mammalian Bop1 0.04810.30732&radic&radic&radic S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.04760.30535&radic&radic&radic&radic&radic&radic S000003324DBF2YGR092WverifiedSer/Thr kinase involved in transcription and stress response;functions as part of a network of genes in exitfrom mitosis; localization is cell cycleregulated; activated by Cdc15p during the exitfrom mitosis 0.046630.2999&radic S000003141KEM1YGL173CverifiedEvolutionarily-conserved 5'-3' exonuclease component ofcytoplasmic processing (P) bodies involved inmRNA decay; plays a role inmicrotubule-mediated processes, filamentousgrowth, ribosomal RNA maturation, and telomeremaintenance &radic0.046410.29894&radic S000000913SWI4YER111CverifiedDNA binding component of the SBF complex (Swi4p-Swi6p), atranscriptional activator that in concert withMBF (Mbp1-Swi6p) regulates late G1-specifictranscription of targets including cyclins andgenes required for DNA synthesis and repair 0.046320.29839&radic&radic S000002622AHA1YDR214WverifiedCo-chaperone that binds to Hsp82p and activates its ATPaseactivity; similar to Hch1p; expression isregulated by stresses such as heat shock 0.045990.29681&radic&radic S000005835SNU66YOR308CverifiedComponent of the U4/U6.U5 snRNP complex involved in pre-mRNAsplicing via spliceosome; has homology to humanSART-1 and to an S. pombe protein; snu66 nullmutation confers cold-sensitivity but is notlethal at normal growth temperatures 0.044990.29098&radic&radic&radic&radic&radic S000005732NOC2YOR206WverifiedProtein that forms a nucleolar complex with Mak21p that bindsto 90S and 66S pre-ribosomes, as well as anuclear complex with Noc3p that binds to 66Spre-ribosomes; both complexes mediateintranuclear transport of ribosomal precursors 0.043680.28466&radic&radic&radic&radic&radic&radic S000003304UPF3YGR072WverifiedComponent of the nonsense-mediated mRNA decay (NMD) pathway,along with Nam7p and Nmd2p; involved in decayof mRNA containing nonsense codons; involved intelomere maintenance &radic0.043380.2831&radic&radic&radic S000002579SUP35YDR172WverifiedTranslation termination factor eRF3; altered proteinconformation creates the [PSI(+)] prion, adominant cytoplasmically inherited proteinaggregate that alters translational fidelityand creates a nonsense suppressor phenotype &radic0.042950.28121&radic&radic&radic&radic&radic S000004800MRPS17YMR188CverifiedMitochondrial ribosomal protein of the small subunit 0.04290.28066&radic&radic S000004284GSP1YLR293CverifiedGTP binding protein (mammalian Ranp homolog) involved in themaintenance of nuclear organization, RNAprocessing and transport; regulated by Prp20p,Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p andKap95p; yeast Gsp2p homolog 0.042790.28017&radic&radic&radic&radic S000005574RAT1YOR048CverifiedNuclear 5' to 3' single-stranded RNA exonuclease, involved inRNA metabolism, including rRNA and snRNAprocessing as well as mRNA transcriptiontermination 0.041470.2742&radic&radic&radic&radic&radic S000003074MLC1YGL106WverifiedEssential light chain for myosin Myo2p; may stabilize Myo2p bybinding to the neck region; may interact withMyo1p, Iqg1p, and Myo2p to coordinate formationand contraction of the actomyosin ring withtargeted membrane deposition 0.041460.27395 S000006158SUI3YPL237WverifiedBeta subunit of the translation initiation factor eIF2,involved in the identification of the startcodon; proposed to be involved in mRNA binding 0.041270.27309&radic&radic S000004410CDC73YLR418CverifiedConstituent of Paf1 complex with RNA polymerase II, Paf1p,Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinctfrom Srb-containing Pol II complexes; requiredfor expression of certain genes, modificationof some histones, and telomere maintenance 0.041060.27192&radic&radic S000004494RAD52YML032CverifiedProtein that stimulates strand exchange by facilitating Rad51pbinding to single-stranded DNA; annealscomplementary single-stranded DNA; involved inthe repair of double-strand breaks in DNAduring vegetative growth and meiosis 0.040530.26873&radic&radic&radic S000002800SPT3YDR392WverifiedSubunit of the SAGA and SAGA-like transcriptional regulatorycomplexes, interacts with Spt15p to activatetranscription of some RNA polymeraseII-dependent genes, also functions to inhibittranscription at some promoters 0.040330.26796&radic&radic S000006072PRP46YPL151CverifiedSplicing factor that is found in the Cef1p subcomplex of thespliceosome 0.040020.26657&radic&radic&radic&radic&radic S000005505CTR9YOL145CverifiedComponent of the Paf1p complex, which is a large complex thatbinds to and modulates the activity of RNApolymerase II and is required for expression ofa subset of genes, including cyclin genes;contains TPR repeats 0.040010.26649&radic S000006314RPC40YPR110CverifiedRNA polymerase subunit, common to RNA polymerase I and III 0.039360.26311&radic&radic&radic S000004961PUB1YNL016WverifiedPoly(A)+ RNA-binding protein, abundant mRNP-component proteinthat binds mRNA and is required for stabilityof a number of mRNAs; not reported to associatewith polyribosomes &radic0.039290.26277&radic&radic S000003190EDC1YGL222CverifiedRNA-binding protein, activates mRNA decapping directly bybinding to the mRNA substrate and enhancing theactivity of the decapping proteins Dcp1p andDcp2p &radic0.039250.26275&radic&radic&radic&radic&radic S000006156RVB2YPL235WverifiedEssential protein involved in transcription regulation;component of chromatin remodeling complexes;required for assembly and function of the INO80complex; member of the RUVB-like protein family 0.03920.26217&radic&radic&radic&radic S000003237TFG2YGR005CverifiedTFIIF (Transcription Factor II) middle subunit; involved inboth transcription initiation and elongation ofRNA polymerase II; homologous to human RAP30 0.038970.26149&radic&radic&radic&radic S000003684RPA34YJL148WverifiedRNA polymerase I subunit A34.5 0.038270.25745&radic&radic&radic S000000950SPT15YER148WverifiedTATA-binding protein, general transcription factor thatinteracts with other factors to form thepreinitiation complex at promoters, essentialfor viability 0.038190.25723&radic S000005483HRP1YOL123WverifiedSubunit of cleavage factor I, a five-subunit complex requiredfor the cleavage and polyadenylation ofpre-mRNA 3' ends; RRM-containing heteronuclearRNA binding protein and hnRNPA/B family memberthat binds to poly (A) signal sequences 0.038160.25714&radic&radic S000001025RPL8AYHL033CverifiedRibosomal protein L4 of the large (60S) ribosomal subunit,nearly identical to Rpl8Bp and has similarityto rat L7a ribosomal protein; mutation resultsin decreased amounts of free 60S subunits 0.038090.25653&radic&radic S000000918SLX8YER116CverifiedProtein containing a RING finger domain that interacts withHex3p; mutant phenotypes and geneticinteractions suggest a role in sumoylation andin genome stability 0.037850.25556&radic&radic S000003466YHB1YGR234WverifiedNitric oxide oxidoreductase, flavohemoglobin involved in nitricoxide detoxification; plays a role in theoxidative and nitrosative stress responses 0.037640.25448&radic&radic&radic S000004356YLR364WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR364W is not an essential gene 0.037630.25433&radic&radic&radic S000005336NOG2YNR053CverifiedPutative GTPase that associates with pre-60S ribosomal subunitsin the nucleolus and is required for theirnuclear export and maturation 0.037260.25251&radic&radic S000000128HEK2YBL032WverifiedRNA binding protein with similarity to hnRNP-K that localizesto the cytoplasm and to subtelomeric DNA;required for the proper localization of ASH1mRNA; involved in the regulation of telomereposition effect and telomere length 0.036890.25069&radic&radic&radic S000001323SNP1YIL061CverifiedComponent of U1 snRNP required for mRNA splicing viaspliceosome; may interact with poly(A)polymerase to regulate polyadenylation; homologof human U1 70K protein 0.036810.25029&radic&radic&radic S000000004SSA1YAL005CverifiedATPase involved in protein folding and nuclear localizationsignal (NLS)-directed nuclear transport; memberof heat shock protein 70 (HSP70) family; formsa chaperone complex with Ydj1p; localized tothe nucleus, cytoplasm, and cell wall 0.036790.25024&radic&radic&radic&radic S000006125HRR25YPL204WverifiedProtein kinase involved in regulating diverse events includingvesicular trafficking, gene expression, DNArepair, and chromosome segregation; binds theCTD of RNA pol II; homolog of mammalian caseinkinase 1delta (CK1delta) 0.036640.24953&radic&radic&radic&radic&radic S000002259DUN1YDL101CverifiedCell-cycle checkpoint serine-threonine kinase required for DNAdamage-induced transcription of certain targetgenes, phosphorylation of Rad55p and Sml1p, andtransient G2/M arrest after DNA damage; alsoregulates postreplicative DNA repair 0.03630.24691&radic&radic S000001163LSM12YHR121WverifiedProtein of unknown function that interacts with Pbp1p and Pbp4pand associates with ribosomes; contains anRNA-binding LSM domain and an AD domain; mayplay a role in RNA processing 0.035220.24084&radic&radic&radic&radic&radic&radic S000000069BUD14YAR014CverifiedProtein involved in bud-site selection, Bud14p-Glc7p complexfunctions as a cortical regulator of dynein;diploid mutants display a random buddingpattern instead of the wild-type bipolarpattern 0.035140.24009&radic&radic&radic&radic&radic S000002467MAK21YDR060WverifiedConstituent of 66S pre-ribosomal particles, required for large(60S) ribosomal subunit biogenesis; involved innuclear export of pre-ribosomes; required formaintenance of dsRNA virus; homolog of humanCAATT-binding protein 0.034670.23802&radic&radic&radic&radic&radic S000005194RAD50YNL250WverifiedSubunit of MRX complex, with Mre11p and Xrs2p, involved inprocessing double-strand DNA breaks invegetative cells, initiation of meiotic DSBs,telomere maintenance, and nonhomologous endjoining 0.034630.23759&radic&radic S000003503SLH1YGR271WverifiedPutative RNA helicase related to Ski2p, involved in translationinhibition of non-poly(A) mRNAs; required forrepressing propagation of dsRNA viruses 0.03440.23663&radic S000005366TOP1YOL006CverifiedTopoisomerase I, nuclear enzyme that relieves torsional strainin DNA by cleaving and re-sealing thephosphodiester backbone; relaxes bothpositively and negatively supercoiled DNA;functions in replication, transcription, andrecombination 0.03420.23543&radic&radic&radic&radic&radic S000003163GCN1YGL195WverifiedPositive regulator of the Gcn2p kinase activity, forms acomplex with Gcn20p; proposed to stimulateGcn2p activation by an uncharged tRNA 0.0340.2343&radic S000003323PRP31YGR091WverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.033890.23353&radic&radic&radic S000003959PRP19YLL036CverifiedSplicing factor associated with the spliceosome; contains aU-box, a motif found in a class of ubiquitinligases 0.033780.23283&radic&radic&radic S000000827GCD11YER025WverifiedGamma subunit of the translation initiation factor eIF2,involved in the identification of the startcodon; binds GTP when forming the ternarycomplex with GTP and tRNAi-Met 0.033510.23136&radic&radic S000000131POL12YBL035CverifiedB subunit of DNA polymerase alpha-primase complex, required forinitiation of DNA replication during mitoticand premeiotic DNA synthesis; also functions intelomere capping and length regulation 0.033030.22828&radic&radic S000003454PET54YGR222WverifiedProtein required for splicing of the COX1 intron AI5 beta; alsospecifically required, together with Pet122pand Pet494p, for translation of the COX3 mRNA;located in the mitochondrial inner membrane 0.032510.22536&radic&radic S000004650NUP116YMR047CverifiedSubunit of the nuclear pore complex (NPC) that is localized toboth sides of the pore; contains a repetitiveGLFG motif that interacts with mRNA exportfactor Mex67p and with karyopherin Kap95p;homologous to Nup100p 0.032130.22296&radic&radic&radic S000004900DSS1YMR287CverifiedRNase, component of the mitochondrial degradosome along withthe ATP-dependent RNA helicase Suv3p; thedegradosome associates with the ribosome andmediates turnover of aberrant or unprocessedRNAs 0.032180.22296&radic&radic S000005636TFC7YOR110WverifiedOne of six subunits of the RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part of theTauA globular domain of TFIIIC that binds DNAat the BoxA promoter sites of tRNA and similargenes 0.031990.22231&radic&radic&radic&radic&radic S000002304COP1YDL145CverifiedAlpha subunit of COPI vesicle coatomer complex, which surroundstransport vesicles in the early secretorypathway 0.031750.22042 S000003012RNA15YGL044CverifiedCleavage and polyadenylation factor I (CF I) component involvedin cleavage and polyadenylation of mRNA 3'ends; interacts with the A-rich polyadenylationsignal in complex with Rna14p and Hrp1p 0.031670.21967&radic S000003698JJJ2YJL162CuncharacterizedProtein of unknown function, contains a J-domain, which is aregion with homology to the E. coli DnaJprotein 0.031450.2183&radic&radic&radic&radic&radic S000000483PAF1YBR279WverifiedRNA polymerase II-associated protein, defines a large complexthat is biochemically and functionally distinctfrom the Srb-Mediator form of Pol II holoenzymeand is required for full expression of a subsetof cell cycle-regulated genes 0.031390.2183&radic S000003038RPB9YGL070CverifiedRNA polymerase II subunit B12.6; contacts DNA; mutations affecttranscription start site; involved in telomeremaintenance 0.031320.21771&radic&radic&radic S000000039CDC24YAL041WverifiedGuanine nucleotide exchange factor (GEF or GDP-release factor)for Cdc42p; required for polarity establishmentand maintenance, and mutants have morphologicaldefects in bud formation and shmooing 0.030870.21502&radic&radic&radic S000006367TIF3YPR163CverifiedTranslation initiation factor eIF-4B, has RNA annealingactivity; contains an RNA recognition motif andbinds to single-stranded RNA 0.030750.2141&radic&radic&radic&radic S000005185ZWF1YNL241CverifiedGlucose-6-phosphate dehydrogenase (G6PD), catalyzes the firststep of the pentose phosphate pathway; involvedin adapting to oxidatve stress; homolog of thehuman G6PD which is deficient in patients withhemolytic anemia 0.030540.21268&radic&radic S000001183RPL42BYHR141CverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl42Ap and has similarity to ratL44; required for propagation of the killertoxin-encoding M1 double-stranded RNA satelliteof the L-A double-stranded RNA virus 0.030480.21204&radic S000000347SUP45YBR143CverifiedPolypeptide release factor involved in translation termination;mutant form acts as a recessive omnipotentsuppressor 0.030350.21151&radic S000000414ERV15YBR210WverifiedProtein of unknown function, has similarity to Erv14p 0.030060.2095&radic&radic&radic S000002510STE5YDR103WverifiedPheromone-responsive scaffold protein; shuttles from thenucleus to the plasma membrane and assembleskinases Ste11p, Ste7p, and Fus3p into aspecific signaling complex; active oligomericform interacts with Ste4p-Ste18p complex 0.030020.2091&radic&radic&radic&radic&radic&radic S000002198NAT1YDL040CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.029470.20619&radic&radic S000002747FCF1YDR339CverifiedEssential nucleolar protein that is a component of the SSU(small subunit) processome involved in thepre-rRNA processing steps of 40S ribosomalsubunit biogenesis; contains a PINc domain;copurifies with Faf1p 0.028850.20243&radic&radic&radic S000000763RAD23YEL037CverifiedProtein with ubiquitin-like N terminus, recognizes and bindsdamaged DNA (with Rad4p) during nucleotideexcision repair; regulates Rad4p levels,subunit of Nuclear Excision Repair Factor 2(NEF2); homolog of human HR23A and HR23Bproteins 0.028790.20192&radic&radic&radic&radic&radic S000001221STB5YHR178WverifiedActivator of multidrug resistance genes, forms a heterodimerwith Pdr1p; contains a Zn(II)2Cys6 zinc fingerdomain that interacts with a PDRE (pleotropicdrug resistance element) in vitro; binds Sin3pin a two-hybrid assay 0.028580.20052&radic&radic&radic&radic S000002558CTH1YDR151CverifiedMember of the CCCH zinc finger family; has similarity tomammalian Tis11 protein, which activatestranscription and also has a role in mRNAdegradation; may function with Tis11p in ironhomeostasis 0.028210.19838&radic&radic S000004045SPT8YLR055CverifiedSubunit of the SAGA transcriptional regulatory complex but notpresent in SAGA-like complex SLIK/SALSA,required for SAGA-mediated inhibition at somepromoters 0.027780.19582&radic&radic&radic S000002648SNU56YDR240CverifiedComponent of U1 snRNP required for mRNA splicing viaspliceosome; yeast specific, no metazoancounterpart; interacts with mRNA in commitmentcomplex 0.027720.19549&radic&radic&radic&radic S000002299RPO21YDL140CverifiedRNA polymerase II largest subunit B220, part of central core;phosphorylation of C-terminal heptapeptiderepeat domain regulates association withtranscription and splicing factors; similar tobacterial beta-prime 0.02770.19506&radic&radic S000002713HNT2YDR305CverifiedDinucleoside triphosphate hydrolase; has similarity to thetumor suppressor FHIT and belongs to thehistidine triad (HIT) superfamily ofnucleotide-binding proteins 0.027650.19478&radic&radic&radic S000005692SWT1YOR166CuncharacterizedPutative protein of unknown function; predicted to contain aPINc domain (PilT N terminus) 0.027530.19407&radic&radic&radic S000000815PRP22YER013WverifiedDEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase,associates with lariat intermediates before thesecond catalytic step of splicing; mediatesATP-dependent mRNA release from the spliceosomeand unwinds RNA duplexes 0.027440.19346&radic&radic&radic&radic&radic S000002796RVS167YDR388WverifiedActin-associated protein, subunit of a complex(Rvs161p-Rvs167p) involved in regulation ofactin cytoskeleton, endocytosis, and viabilityfollowing starvation or osmotic stress; homologof mammalian amphiphysin 0.027170.19161&radic&radic&radic S000002973COG7YGL005CverifiedComponent of the conserved oligomeric Golgi complex (Cog1pthrough Cog8p), a cytosolic tethering complexthat functions in protein trafficking tomediate fusion of transport vesicles to Golgicompartments 0.0270.19086&radic&radic S000001076PIH1YHR034CverifiedProtein of unresolved function; may function in protein foldingand/or rRNA processing, interacts with achaperone (Hsp82p), two chromatin remodelingfactors (Rvb1p, Rvb2p) and two rRNA processingfactors (Rrp43p, Nop58p) 0.026940.19054&radic&radic&radic S000005784HNT3YOR258WverifiedMember of the third branch of the histidine triad (HIT)superfamily of nucleotide-binding proteins;similar to Aprataxin, a Hint related proteinthat is mutated in individuals with ataxia withoculomotor apraxia 0.026920.19017&radic&radic&radic&radic S000005975LEE1YPL054WverifiedZinc-finger protein of unknown function 0.026780.1894&radic&radic S000001332MAM33YIL070CverifiedAcidic protein of the mitochondrial matrix involved inoxidative phosphorylation; related to the humancomplement receptor gC1q-R 0.02680.1894 S000005738STE4YOR212WverifiedG protein beta subunit, forms a dimer with Ste18p to activatethe mating signaling pathway, forms aheterotrimer with Gpa1p and Ste18p to dampensignaling; may recruit Rho1p to the polarizedgrowth site during mating; contains WD40repeats 0.026730.18882&radic&radic&radic S000004393DUS3YLR401CuncharacterizedDihydrouridine synthase, member of a widespread family ofconserved proteins including Smm1p, Dus1p, andDus4p; contains a consensus oleate responseelement (ORE) in its promoter region 0.026730.18882&radic&radic&radic&radic S000006161HSP82YPL240CverifiedCytoplasmic chaperone (Hsp90 family) required for pheromonesignaling and negative regulation of Hsf1p;docks with the mitochondrial import receptorTom70p for preprotein delivery; interacts withco-chaperones Cns1p, Cpr6p, Cpr7p, and Sti1p 0.026670.18853&radic&radic&radic&radic S000002508ARX1YDR101CverifiedShuttling pre-60S factor; involved in the biogenesis ofribosomal large subunit biogenesis; interactsdirectly with Alb1; responsible for Tif6recycling defects in absence of Rei1;associated with the ribosomal export complex 0.026480.18727&radic&radic S000001697YRA2YKL214CverifiedMember of the REF (RNA and export factor binding proteins)family; when overexpressed, can substitute forthe function of Yra1p in export of poly(A)+mRNA from the nucleus 0.026390.18641&radic&radic&radic&radic&radic S000001504MAK11YKL021CverifiedProtein essential for cell growth and replication of M dsRNAvirus; contains four beta-transducin repeats 0.026320.18599&radic&radic&radic&radic&radic S000001792HBS1YKR084CverifiedGTP binding protein with sequence similarity to the elongationfactor class of G proteins, EF-1alpha andSup35p; associates with Dom34p, and shares asimilar genetic relationship with genes thatencode ribosomal protein components 0.026240.18559&radic&radic&radic S000004389AFG2YLR397CverifiedATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexamericcomplex; may be involved in degradation ofaberrant mRNAs 0.026180.18508&radic&radic&radic&radic S000001236EGD2YHR193CverifiedAlpha subunit of the heteromeric nascent polypeptide-associatedcomplex (NAC) involved in protein sorting andtranslocation, associated with cytoplasmicribosomes 0.02610.18453&radic S000005119NOP13YNL175CverifiedProtein of unknown function, localizes to the nucleolus andnucleoplasm; contains an RNA recognition motif(RRM) and has similarity to Nop12p, which isrequired for processing of pre-18S rRNA 0.025980.1839&radic&radic&radic&radic&radic&radic S000005617TMA46YOR091WverifiedProtein of unknown function that associates with ribosomes;interacts with GTPase Rbg1p 0.025990.1839&radic&radic&radic&radic S000000449ISW1YBR245CverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPase thatforms a complex with Ioc2p and Ioc4p toregulate transcription elongation, and acomplex with Ioc3p to repress transcriptioninitiation 0.025860.18309&radic&radic&radic S000002793EFT2YDR385WverifiedElongation factor 2 (EF-2), also encoded by EFT1; catalyzesribosomal translocation during proteinsynthesis; contains diphthamide, the uniqueposttranslationally modified histidine residuespecifically ADP-ribosylated by diphtheriatoxin 0.025870.18309&radic&radic S000001377NUP159YIL115CverifiedSubunit of the nuclear pore complex that is found exclusivelyon the cytoplasmic side, forms a subcomplexwith Nup82p and Nsp1p, required for mRNA export 0.025780.18262 S000003307PRP38YGR075CverifiedUnique component of the U4/U6.U5 tri-snRNP particle,dispensable for spliceosome assembly, butrequired for conformational changes which leadto catalytic activation of the spliceosome 0.025790.18262&radic&radic&radic&radic S000002614EBS1YDR206WverifiedCytoplasmic protein of unknown function, involved in inhibitionof translation; interacts with cap bindingprotein Cdc33; contains an RNA recognitionmotif and similarity to Est1p; mRNA abundanceregulated by mRNA decay factors 0.02570.18214&radic S000004970SSN8YNL025CverifiedCyclin-like component of the RNA polymerase II holoenzyme,involved in phosphorylation of the RNApolymerase II C-terminal domain; involved inglucose repression and telomere maintenance 0.025670.1819&radic&radic S000002245LUC7YDL087CverifiedEssential protein associated with the U1 snRNP complex;splicing factor involved in recognition of 5'splice site 0.025620.18166&radic S000003131RAD54YGL163CverifiedDNA-dependent ATPase, stimulates strand exchange by modifyingthe topology of double-stranded DNA; involvedin the recombinational repair of double-strandbreaks in DNA during vegetative growth andmeiosis; member of the SWI/SNF family 0.02550.18096&radic&radic S000000201PKC1YBL105CverifiedProtein serine/threonine kinase essential for cell wallremodeling during growth; localized to sites ofpolarized growth and the mother-daughter budneck; homolog of the alpha, beta, and gammaisoforms of mammalian protein kinase C (PKC) 0.025330.17968&radic S000006014NOG1YPL093WverifiedPutative GTPase that associates with free 60S ribosomalsubunits in the nucleolus and is required for60S ribosomal subunit biogenesis; constituentof 66S pre-ribosomal particles; member of theODN family of nucleolar G-proteins 0.025320.17949&radic&radic&radic S000005561SHE4YOR035CverifiedProtein containing a UCS (UNC-45/CRO1/SHE4) domain, binds tomyosin motor domains to regulate myosinfunction; involved in endocytosis, polarizationof the actin cytoskeleton, and asymmetric mRNAlocalization 0.025320.17949&radic S000005029MKT1YNL085WverifiedProtein that forms a complex with Pbp1p that may mediateposttranscriptional regulation of HOendonuclease; involved in propagation of M2dsRNA satellite of L-A virus 0.025250.17887&radic S000000298PBY1YBR094WuncharacterizedP-body associated protein 0.025160.17826&radic S000004837MRE11YMR224CverifiedSubunit of a complex with Rad50p and Xrs2p (RMX complex) thatfunctions in repair of DNA double-strand breaksand in telomere stability, exhibits nucleaseactivity that appears to be required for RMXfunction; widely conserved 0.024940.17676&radic&radic&radic&radic S000006152FAS2YPL231WverifiedAlpha subunit of fatty acid synthetase, which catalyzes thesynthesis of long-chain saturated fatty acids;contains beta-ketoacyl reductase andbeta-ketoacyl synthase activities 0.024820.17585&radic&radic&radic S000004354STE11YLR362WverifiedSignal transducing MEK kinase involved in pheromone responseand pseudohyphal/invasive growth pathways whereit phosphorylates Ste7p, and the highosmolarity response pathway, viaphosphorylation of Pbs2p; regulated by Ste20pand Ste50p 0.024790.1756&radic&radic&radic&radic S000005802CAF20YOR276WverifiedPhosphoprotein of the mRNA cap-binding complex involved intranslational control, repressor ofcap-dependent translation initiation, competeswith eIF4G for binding to eIF4E 0.024810.1756&radic S000001804YKR096WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and to the cytoplasm; predicted to contain a PINc (PilT N terminus) domain; YKR096W is not an essential gene 0.024690.17453&radic&radic S000001447PRI1YIR008CverifiedSubunit of DNA primase, which is required for DNA synthesis anddouble-strand break repair 0.024420.17271 S000000786PRB1YEL060CverifiedVacuolar proteinase B (yscB), a serine protease of thesubtilisin family; involved in proteindegradation in the vacuole and required forfull protein degradation during sporulation 0.024450.17271&radic&radic S000005713TUF1YOR187WverifiedMitochondrial translation elongation factor Tu; comprises bothGTPase and guanine nucleotide exchange factoractivities, while these activities are found inseparate proteins in S. pombe and humans 0.024110.17078&radic S000002552TAF12YDR145WverifiedSubunit (61/68 kDa) of TFIID and SAGA complexes, involved inRNA polymerase II transcription initiation andin chromatin modification, similar to histoneH2A 0.024010.16997&radic&radic&radic&radic S000004312MMS22YLR320WverifiedProtein involved in resistance to ionizing radiation; acts withMms1p in a repair pathway that may be involvedin resolving replication intermediates orpreventing the damage caused by blockedreplication forks 0.023860.16871&radic&radic S000001066MAS2YHR024CverifiedLarger subunit of the mitochondrial processing protease (MPP),essential processing enzyme that cleaves theN-terminal targeting sequences frommitochondrially imported proteins 0.023710.16779&radic&radic&radic S000001528PRI2YKL045WverifiedSubunit of DNA primase, which is required for DNA synthesis anddouble-strand break repair 0.023680.16779&radic&radic&radic S000003548RPC17YJL011CverifiedRNA polymerase III subunit C17; physically interacts with C31,C11, and TFIIIB70; may be involved in therecruitment of pol III by the preinitiationcomplex 0.023330.16514&radic&radic S000000897RAD51YER095WverifiedStrand exchange protein, forms a helical filament with DNA thatsearches for homology; involved in therecombinational repair of double-strand breaksin DNA during vegetative growth and meiosis;homolog of Dmc1p and bacterial RecA protein 0.023240.16457&radic&radic S000001930PHO4YFR034CverifiedBasic helix-loop-helix (bHLH) transcription factor; bindscooperatively with Pho2p to the PHO5 promoter;function is regulated by phosphorylation atmultiple sites and by phosphate availability 0.023180.16412&radic&radic&radic&radic&radic&radic S000003335NOP7YGR103WverifiedNucleolar protein involved in rRNA processing and 60S ribosomalsubunit biogenesis; constituent of severaldifferent pre-ribosomal particles; required forexit from G0 and the initiation ofcell proliferation 0.023160.16407&radic&radic&radic&radic&radic&radic S000001057MIP6YHR015WverifiedPutative RNA-binding protein, interacts with Mex67p, which is acomponent of the nuclear pore involved innuclear mRNA export 0.023140.16359&radic&radic S000001052RPL27AYHR010WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl27Bp and has similarity to ratL27 ribosomal protein 0.023120.16359&radic&radic&radic S000003563RNR2YJL026WverifiedRibonucleotide-diphosphate reductase (RNR), small subunit; theRNR complex catalyzes the rate-limiting step indNTP synthesis and is regulated by DNAreplication and DNA damage checkpoint pathwaysvia localization of the small subunits 0.023070.16331&radic&radic&radic S000004315CWC24YLR323CverifiedEssential protein, component of a complex containing Cef1p; hassimilarity to S. pombe Cwf24p 0.0230.16281&radic&radic S000003666URA2YJL130CverifiedBifunctional carbamoylphosphate synthetase (CPSase)-aspartatetranscarbamylase (ATCase), catalyzes the firsttwo enzymatic steps in the de novo biosynthesisof pyrimidines; both activities are subject tofeedback inhibition by UTP 0.022420.15877&radic&radic&radic S000000602RVS161YCR009CverifiedAmphiphysin-like lipid raft protein; subunit of a complex(Rvs161p-Rvs167p) that regulates polarizationof the actin cytoskeleton, endocytosis, cellpolarity, cell fusion and viability followingstarvation or osmotic stress 0.022390.15857&radic&radic&radic S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling 0.022360.15845&radic&radic&radic&radic&radic&radic&radic S000002577SEC7YDR170CverifiedGuanine nucleotide exchange factor (GEF) for ADP ribosylationfactors involved in proliferation of the Golgi,intra-Golgi transport and ER-to-Golgitransport; found in the cytoplasm and onGolgi-associated coated vesicles 0.022260.15777&radic&radic&radic S000001413YIL151CUncharacterizedPutative protein of unknown function, predicted to contain a PINc (PilT N terminus) domain 0.022150.1571 S000004069SIC1YLR079WverifiedInhibitor of Cdc28-Clb kinase complexes that controls G1/Sphase transition, preventing premature S phaseand ensuring genomic integrity; phosphorylationtargets Sic1p for SCF(CDC4)-dependent turnover;functional homolog of mammalian Kip1 0.022060.15657&radic&radic&radic&radic&radic S000006388GDB1YPR184WverifiedGlycogen debranching enzyme containing glucanotranferase andalpha-1,6-amyloglucosidase activities, requiredfor glycogen degradation 0.021980.15589&radic&radic&radic S000003931DRS1YLL008WverifiedNucleolar DEAD-box protein required for ribosome assembly andfunction, including synthesis of 60S ribosomalsubunits; constituent of 66S pre-ribosomalparticles 0.021770.15443&radic&radic&radic&radic&radic&radic S000002856ADA2YDR448WverifiedTranscription coactivator, component of the ADA and SAGAtranscriptional adaptor/HAT (histoneacetyltransferase) complexes 0.021740.15423&radic&radic S000000824SRB4YER022WverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation 0.021710.15401&radic&radic S000003245SNU71YGR013WverifiedComponent of U1 snRNP required for mRNA splicing viaspliceosome; yeast specific, no metazoancounterpart 0.021670.15388&radic&radic&radic S000000883SER3YER081Wverified3-phosphoglycerate dehydrogenase, catalyzes the first step inserine and glycine biosynthesis; isozyme ofSer33p 0.021530.15295&radic&radic&radic S000005963SSN3YPL042CverifiedCyclin-dependent protein kinase, component of RNA polymerase IIholoenzyme; involved in phosphorylation of theRNA polymerase II C-terminal domain; involvedin glucose repression 0.02140.15202&radic&radic&radic S000005572DBP5YOR046CverifiedCytoplasmic ATP-dependent RNA helicase of the DEAD-box familyinvolved in mRNA export from the nucleus 0.021370.15186&radic&radic S000005964NOP4YPL043WverifiedNucleolar protein, essential for processing and maturation of27S pre-rRNA and large ribosomal subunitbiogenesis; constituent of 66S pre-ribosomalparticles; contains four RNA recognition motifs(RRMs) 0.021160.15025&radic&radic&radic&radic S000003410PBP1YGR178CverifiedProtein interacting with poly(A)-binding protein Pab1p; likelyinvolved in controlling the extent of mRNApolyadenylation; forms a complex with Mkt1pthat may regulate HO translation; interactswith Lsm12p in a copurification assay 0.021060.14966&radic&radic&radic&radic&radic S000003949HSP104YLL026WverifiedHeat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p(Hsp70) to refold and reactivate previouslydenatured, aggregated proteins; responsive tostresses including: heat, ethanol, and sodiumarsenite; involved in [PSI+] propagation 0.020990.14933&radic&radic&radic S000002708PRO1YDR300CverifiedGamma-glutamyl kinase, catalyzes the first step in prolinebiosynthesis 0.020960.14924&radic&radic&radic&radic S000000322TEF2YBR118WverifiedTranslational elongation factor EF-1 alpha; also encoded byTEF1; functions in the binding reaction ofaminoacyl-tRNA (AA-tRNA) to ribosomes 0.020880.14838&radic S000006316MRD1YPR112CverifiedEssential conserved protein that associates with 35S precursorrRNA and is required for its initial processingat the A(0)-A(2) cleavage sites, shows partialnucleolar localization, contains five consensusRNA-binding domains 0.020630.1468&radic&radic&radic&radic S000005589RPL3YOR063WverifiedProtein component of the large (60S) ribosomal subunit, hassimilarity to E. coli L3 and rat L3 ribosomalproteins; involved in the replication andmaintenance of killer double stranded RNA virus 0.020610.14654&radic&radic S000006074RAD53YPL153CverifiedProtein kinase, required for cell-cycle arrest in response toDNA damage; activated by transautophosphorylation when interacting withhyperphosphorylated Rad9p; also interacts withARS1 and plays a role in initiation of DNAreplication 0.020510.14584&radic&radic&radic&radic&radic S000004076SMC4YLR086WverifiedSubunit of the condensin complex, which reorganizes chromosomesduring cell division, forms a stable complexwith Smc2p that has ATP-hydrolyzing andDNA-binding activity and promotes knotting ofcircular DNA; potential Cdc28p substrate 0.020490.14574&radic&radic&radic S000001056SPO13YHR014WverifiedMeiosis-specific protein, involved in maintaining sisterchromatid cohesion during meiosis I as well aspromoting proper attachment of kinetochores tothe spindle during meiosis I and meiosis II 0.020470.1456&radic&radic&radic&radic&radic S000005133SRP1YNL189WverifiedKaryopherin alpha homolog, forms a dimer with karyopherin betaKap95p to mediate import of nuclear proteins,binds the nuclear localization signal of thesubstrate during import; may also play a rolein regulation of protein degradation 0.020460.14517&radic&radic&radic&radic&radic S000000517GBP2YCL011CverifiedPoly(A+) RNA-binding protein, involved in the export of mRNAsfrom the nucleus to the cytoplasm; similar toHrb1p and Npl3p; also binds single-strandedtelomeric repeat sequence in vitro 0.020450.14517&radic&radic&radic&radic S000005165POP1YNL221CverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends; binds to the RPR1 RNAsubunit in Rnase P 0.020350.14485&radic&radic&radic S000004061RGR1YLR071CverifiedComponent of RNA polymerase II holoenzyme/mediator complex;affects chromatin structure and transcriptionalregulation of diverse genes; required forglucose repression, HO repression, RME1repression and sporulation 0.020360.14485&radic&radic&radic&radic S000001055ARD1YHR013CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.020160.14361&radic&radic&radic S000003730CDC6YJL194WverifiedEssential ATP-binding protein required for DNA replication,component of the pre-replicative complex(pre-RC) which requires ORC to associate withchromatin and is in turn required for Mcm2-7pDNA association; homologous to S. pombe Cdc18p 0.020080.14304&radic&radic&radic&radic&radic S000006311YTH1YPR107CverifiedEssential RNA-binding component of cleavage and polyadenylationfactor, contains five zinc fingers; requiredfor pre-mRNA 3'-end processing andpolyadenylation 0.020010.14249&radic&radic S000000168RPS8AYBL072CverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps8Bp and has similarity to ratS8 ribosomal protein 0.019940.14213&radic&radic&radic&radic S000003432ELP2YGR200CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;target of Kluyveromyces lactis zymocin 0.01980.1409&radic&radic S000001072SLT2YHR030CverifiedSerine/threonine MAP kinase involved in regulating themaintenance of cell wall integrity andprogression through the cell cycle; regulatedby the PKC1-mediated signaling pathway 0.019810.1409&radic&radic&radic&radic S000006132NIP7YPL211WverifiedNucleolar protein required for 60S ribosome subunit biogenesis,constituent of 66S pre-ribosomal particles;physically interacts with Nop8p and the exosomesubunit Rrp43p 0.019760.14078&radic&radic&radic&radic S000001506YKL023WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.019620.13975&radic&radic&radic S000003676RPB4YJL140WverifiedRNA polymerase II subunit B32; forms two subunit dissociablecomplex with Rpb7p; dispensable under someenvironmental conditions; involved in export ofmRNA to cytoplasm under stress conditions;involved in telomere maintenance &radic0.019390.13829&radic S000004322CHS5YLR330WverifiedProtein involved in export from the Golgi to plasma membrane;involved in chitin biosynthesis through itsrole in Chs3p localization; interacts withArf1p, Bch1p, Fmp50p, Bud7p, and Chs6p 0.019370.13813&radic&radic S000004409VPS36YLR417WverifiedComponent of the ESCRT-II complex; contains the GLUE (GRAM LikeUbiquitin binding in EAP45) domain which isinvolved in interactions with ESCRT-I andubiquitin-dependent sorting of proteins intothe endosome 0.019310.13739&radic&radic&radic&radic S000004886ZDS1YMR273CverifiedProtein that interacts with silencing proteins at the telomere,involved in transcriptional silencing; has arole in localization of Bcy1p, a regulatorysubunit of protein kinase A; implicated in mRNAnuclear export 0.019260.13733&radic&radic&radic&radic S000000402TAF5YBR198CverifiedSubunit (90 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification 0.018880.13458&radic&radic&radic S000000364CDC28YBR160WverifiedCatalytic subunit of the main cell cycle cyclin-dependentkinase (CDK); alternately associates with G1cyclins (CLNs) and G2/M cyclins (CLBs) whichdirect the CDK to specific substrates 0.018880.13454&radic&radic S000004099AHP1YLR109WverifiedThiol-specific peroxiredoxin, reduces hydroperoxides to protectagainst oxidative damage; function in vivorequires covalent conjugation to Urm1p 0.018820.13389&radic&radic&radic&radic&radic S000004901HSH155YMR288WverifiedU2-snRNP associated splicing factor that forms extensiveassociations with the branch site-3' splicesite-3' exon region upon prespliceosomeformation; similarity to the mammalian U2snRNP-associated splicing factor SAP155 0.018770.13371&radic&radic&radic&radic&radic S000006339CTF4YPR135WverifiedChromatin-associated protein, required for sister chromatidcohesion; interacts with DNA polymerase alpha(Pol1p) and may link DNA synthesis to sisterchromatid cohesion 0.018730.13334&radic&radic&radic&radic S000002794MUS81YDR386WverifiedHelix-hairpin-helix protein, involved in DNA repair andreplication fork stability; functions as anendonuclease in complex with Mms4p; interactswith Rad54p 0.01870.13323&radic&radic&radic&radic&radic S000002769BCP1YDR361CverifiedEssential protein involved in nuclear export of Mss4p, which isa lipid kinase that generatesphosphatidylinositol 4,5-biphosphate and playsa role in actin cytoskeleton organization andvesicular transport 0.018670.13298&radic&radic&radic&radic&radic S000002771ESC2YDR363WverifiedProtein involved in mating-type locus silencing, interacts withSir2p; probably functions to recruit orstabilize Sir proteins 0.018620.13257&radic&radic&radic S000004903HAS1YMR290CverifiedATP-dependent RNA helicase; localizes to both the nuclearperiphery and nucleolus; highly enriched innuclear pore complex fractions; constituent of66S pre-ribosomal particles 0.018560.13194&radic&radic&radic&radic S000000277RDH54YBR073WverifiedDNA-dependent ATPase, stimulates strand exchange by modifyingthe topology of double-stranded DNA; involvedin the recombinational repair of double-strandbreaks in DNA during mitosis and meiosis;proposed to be involved in crossoverinterference 0.018480.13154&radic S000003220HFM1YGL251CverifiedMeiosis specific DNA helicase involved in the conversion ofdouble-stranded breaks to later recombinationintermediates and in crossover control;catalyzes the unwinding of Holliday junctions;has ssDNA and dsDNA stimulated ATPase activity 0.018460.13124&radic&radic S000003011DST1YGL043WverifiedGeneral transcription elongation factor TFIIS, enables RNApolymerase II to read through blocks toelongation by stimulating cleavage of nascenttranscripts stalled at transcription arrestsites 0.018430.13124&radic&radic&radic&radic&radic S000003026RAD6YGL058WverifiedUbiquitin-conjugating enzyme (E2), involved in postreplicationrepair (with Rad18p), sporulation, telomeresilencing, and ubiquitin-mediated N-end ruleprotein degradation (with Ubr1p) 0.018420.13118&radic&radic&radic&radic&radic S000006323CLB2YPR119WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the transition from G2 to Mphase; accumulates during G2 and M, thentargeted via a destruction box motif forubiquitin-mediated degradation by theproteasome 0.018410.13099&radic&radic S000003215RAI1YGL246CverifiedNuclear protein that binds to and stabilizes theexoribonuclease Rat1p, required for pre-rRNAprocessing 0.018360.13068&radic&radic&radic&radic S000001083SRB2YHR041CverifiedGeneral transcription factor, subunit of the RNA polymerase IImediator complex; associates with corepolymerase subunits to form the RNA polymeraseII holoenzyme; involved in telomere maintenance 0.018240.12974&radic&radic&radic S000006061MKK2YPL140CverifiedMitogen-activated kinase kinase involved in protein kinase Csignaling pathway that controls cell integrity;upon activation by Bck1p phosphorylatesdownstream target, Slt2p; functionallyredundant with Mkk1p 0.01820.12955&radic&radic S000004700CTF13YMR094WverifiedSubunit of the CBF3 complex, which binds to the CDE III elementof centromeres, bending the DNA upon binding,and may be involved in sister chromatidcohesion during mitosis 0.018140.12913 S000003796RAD26YJR035WverifiedProtein involved in transcription-coupled repair nucleotideexcision repair of UV-induced DNA lesions;homolog of human CSB protein 0.018040.12832&radic&radic S000006010RLM1YPL089CverifiedMADS-box transcription factor, component of the protein kinaseC-mediated MAP kinase pathway involved in themaintenance of cell integrity; phosphorylatedand activated by the MAP-kinase Slt2p 0.018030.12816&radic&radic&radic&radic S000001016RIM4YHL024WverifiedPutative RNA-binding protein required for the expression ofearly and middle sporulation genes 0.017950.12761 S000005671PNO1YOR145CverifiedEssential nucleolar protein required for pre-18S rRNAprocessing, interacts with Dim1p, an 18S rRNAdimethyltransferase, and also with Nob1p, whichis involved in proteasome biogenesis; containsa KH domain 0.017930.12755&radic&radic S000000104HIR1YBL008WverifiedNon-essential transcriptional corepressor involved in the cellcycle-regulated transcription of histone H2A,H2B, H3 and H4 genes; contributes to nucleosomeformation, heterochromatic gene silencing, andformation of functional kinetochores 0.01780.12656&radic&radic&radic&radic S000003893NMD5YJR132WverifiedKaryopherin, a carrier protein involved in nuclear import ofproteins; importin beta homolog 0.017770.12627&radic&radic S000002243NDE2YDL085WverifiedMitochondrial external NADH dehydrogenase, catalyzes theoxidation of cytosolic NADH; Nde1p and Nde2pare involved in providing the cytosolic NADH tothe mitochondrial respiratory chain 0.017740.12613 S000001283RPB3YIL021WverifiedRNA polymerase II third largest subunit B44, part of centralcore; similar to prokaryotic alpha subunit 0.017720.12551&radic&radic S000006368MMS1YPR164WverifiedProtein likely involved in protection againstreplication-dependent DNA damage; mutants aresensitive to methyl methanesulfonate (MMS);implicated in regulation of Ty1 transposition 0.017710.12551&radic S000003242NMA2YGR010WverifiedNicotinic acid mononucleotide adenylyltransferase, involved inNAD(+) salvage pathway 0.017670.12548&radic&radic&radic&radic S000001877GNA1YFL017CverifiedEvolutionarily conserved glucosamine-6-phosphateacetyltransferase required for multiple cellcycle events including passage through START,DNA synthesis, and mitosis; involved inUDP-N-acetylglucosamine synthesis, formsGlcNAc6P from AcCoA 0.017660.12537&radic&radic&radic&radic&radic S000000885GET2YER083CverifiedSubunit of the GET complex; required for meiotic nucleardivision and for the retrieval of HDEL proteinsfrom the Golgi to the ER in an ERD2 dependentfashion; may be involved in cell wall function 0.01760.12468&radic&radic S000002372NOP6YDL213CuncharacterizedProtein with similarity to hydrophilins, which are involved inthe adaptive response to hyperosmoticconditions; computational analysis oflarge-scale protein-protein interaction datasuggests a possible role in rRNA processing 0.017530.12438&radic&radic S000005274RPD3YNL330CverifiedHistone deacetylase; regulates transcription and silencing 0.017540.12438&radic&radic&radic&radic S000005735NPT1YOR209CverifiedNicotinate phosphoribosyltransferase, acts in the salvagepathway of NAD+ biosynthesis; required forsilencing at rDNA and telomeres and has a rolein silencing at mating-type loci; localized tothe nucleus 0.017510.12424&radic&radic&radic&radic&radic S000002483RAD55YDR076WverifiedProtein that stimulates strand exchange by stabilizing thebinding of Rad51p to single-stranded DNA;involved in the recombinational repair ofdouble-strand breaks in DNA during vegetativegrowth and meiosis; forms heterodimer withRad57p 0.017470.124&radic&radic&radic&radic&radic&radic S000004855RPL20AYMR242CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl20Bp and has similarity to ratL18a ribosomal protein 0.017470.1239&radic&radic&radic S000005042RAS2YNL098CverifiedGTP-binding protein that regulates the nitrogen starvationresponse, sporulation, and filamentous growth;farnesylation and palmitoylation required foractivity and localization to plasma membrane;homolog of mammalian Ras proto-oncogenes 0.017450.12358&radic&radic S000001855ACT1YFL039CverifiedActin, structural protein involved in cell polarization,endocytosis, and other cytoskeletal functions 0.017330.1229 S000006124TPK2YPL203WverifiedSubunit of cytoplasmic cAMP-dependent protein kinase, whichcontains redundant catalytic subunits Tpk1p,Tpk2p, and Tpk3p and regulatory subunit Bcy1p;promotes vegetative growth in response tonutrients; activates filamentous growth 0.01730.1226&radic&radic&radic&radic S000001295BCY1YIL033CverifiedRegulatory subunit of the cyclic AMP-dependent protein kinase(PKA), a component of a signaling pathway thatcontrols a variety of cellular processes,including metabolism, cell cycle, stressresponse, stationary phase, and sporulation 0.017270.12229&radic&radic&radic S000005564HIR2YOR038CverifiedNon-essential transcriptional corepressor involved in the cellcycle-regulated transcription of histone H2A,H2B, H3, and H4 genes; recruits Swi-Snfcomplexes to histone gene promoters; promotesheterochromatic gene silencing with Asf1p 0.017270.12229&radic&radic&radic S000003035NPY1YGL067WverifiedNADH diphosphatase (pyrophosphatase), hydrolyzes thepyrophosphate linkage in NADH and relatednucleotides; localizes to peroxisomes 0.017230.12209&radic&radic&radic&radic&radic S000004564TAF13YML098WverifiedTFIID subunit (19 kDa), involved in RNA polymerase IItranscription initiation, similar to histone H4with atypical histone fold motif of Spt3-liketranscription factors 0.017230.12209&radic&radic&radic S000000038CLN3YAL040CverifiedG1 cyclin involved in cell cycle progression; activates Cdc28pkinase to promote the G1 to S phase transition;plays a role in regulating transcription of theother G1 cyclins, CLN1 and CLN2; regulated byphosphorylation and proteolysis 0.017190.12181&radic S000002851SSN2YDR443CverifiedProtein required for stable association of Srb10p-Srb11p kinasewith RNA polymerase holoenzyme; subunit of theRNA polymerase II mediator complex; essentialfor transcriptional regulation 0.017180.12157&radic&radic S000000263AKL1YBR059CverifiedSer-Thr protein kinase, member (with Ark1p and Prk1p) of theArk kinase family; involved in endocytosis andactin cytoskeleton organization 0.017130.12119&radic S000002368CWC2YDL209CverifiedProtein involved in pre-mRNA splicing, component of a complexcontaining Cef1p; interacts with Prp19p;contains an RNA recognition motif; hassimilarity to S. pombe Cwf2p 0.016950.12014&radic S000002528DPB4YDR121WverifiedShared subunit of DNA polymerase epsilon and of ISW2/yCHRACchromatin accessibility complex; involved inboth chromosomal DNA replication and ininheritance of telomeric silencing 0.016940.11994&radic&radic&radic&radic&radic S000007270COBQ0105verifiedCytochrome b, mitochondrially encoded subunit of theubiquinol-cytochrome c reductase complex whichincludes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p,Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p 0.016940.11994 S000002847LRS4YDR439WverifiedProtein involved in rDNA silencing; positively chargedcoiled-coil protein with limited similarity tomyosin 0.016870.11957&radic&radic S000004444SST2YLR452CverifiedGTPase-activating protein for Gpa1p, regulates desensitizationto alpha factor pheromone; also required toprevent receptor-independent signaling of themating pathway; member of the RGS (regulator ofG-protein signaling) family 0.016870.11957&radic S000000837EDC2YER035WverifiedRNA-binding protein, activates mRNA decapping directly bybinding to the mRNA substrate and enhancing theactivity of the decapping proteins Dcp1p andDcp2p &radic0.016850.11944&radic&radic&radic&radic&radic S000003096CWC23YGL128CverifiedComponent of a complex containing Cef1p, putatively involved inpre-mRNA splicing; has similarity to E. coliDnaJ and other DnaJ-like proteins and to S.pombe Cwf23p 0.016780.11889&radic&radic&radic S000000292POL30YBR088CverifiedProliferating cell nuclear antigen (PCNA), functions as thesliding clamp for DNA polymerase delta; mayfunction as a docking site for other proteinsrequired for mitotic and meiotic chromosomalDNA replication and for DNA repair 0.016780.11889&radic&radic S000005150RTT106YNL206CverifiedProtein with a role in regulation of Ty1 transposition 0.016740.11865&radic&radic&radic&radic&radic S000001622CTK1YKL139WverifiedCatalytic (alpha) subunit of C-terminal domain kinase I(CTDK-I), which phosphorylates the C-terminalrepeated domain of the RNA polymerase II largesubunit (Rpo21p) to affect both transcriptionand pre-mRNA 3' end processing 0.016740.11865&radic&radic&radic S000003039AFT1YGL071WverifiedTranscription factor involved in iron utilization andhomeostasis; binds the consensus sitePyPuCACCCPu and activates the expression oftarget genes in response to changes in ironavailability 0.016630.1179&radic&radic&radic&radic&radic S000006105MRN1YPL184CuncharacterizedPutative RNA binding protein 0.016620.11782&radic&radic&radic&radic&radic S000003098CEG1YGL130WverifiedAlpha (guanylyltransferase) subunit of the mRNA capping enzyme,a heterodimer (the other subunit is CET1, anRNA 5'-triphophatase) involved in adding the 5'cap to mRNA; the mammalian enzyme is a singlebifunctional polypeptide 0.016550.11724&radic&radic S000004416SPP382YLR424WverifiedEssential protein that forms a dimer with Ntr2p; also forms atrimer, with Ntr2p and Prp43p, that is involvedin spliceosome disassembly; found also in amultisubunit complex with the splicing factorClf1p; suppressor of prp38-1 mutation 0.01650.1169&radic&radic&radic S000003628HPR5YJL092WverifiedDNA helicase and DNA-dependent ATPase involved in DNA repair,required for proper timing of commitment tomeiotic recombination and the transition fromMeiosis I to Meiosis II; potential Cdc28psubstrate 0.016460.11667&radic S000001857TUB2YFL037WverifiedBeta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p)to form tubulin dimer, which polymerizes toform microtubules 0.016420.11632&radic&radic&radic S000003811ISY1YJR050WverifiedComponent of the spliceosome complex involved in pre-mRNAsplicing, auxiliary splicing factor that maymodulate Syf1p activity and help optimizesplicing; isy1 syf2 double mutation activatesthe spindle checkpoint, causing cell cyclearrest 0.016320.11534&radic&radic S000005141WHI3YNL197CverifiedRNA binding protein that sequesters CLN3 mRNA in cytoplasmicfoci; cytoplasmic retention factor for Cdc28pand associated cyclins; regulates cell fate anddose-dependently regulates the critical cellsize required for passage through Start 0.016110.11389&radic&radic S000001551NUP100YKL068WverifiedSubunit of the nuclear pore complex (NPC) that is localized toboth sides of the pore; contains a repetitiveGLFG motif that interacts with mRNA exportfactor Mex67p and with karyopherin Kap95p;homologous to Nup116p 0.01610.11389&radic&radic S000001695SAC1YKL212WverifiedLipid phosphoinositide phosphatase of the ER and Golgi,involved in protein trafficking and secretion 0.015990.11299&radic&radic S000004849TAF9YMR236WverifiedSubunit (17 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification, similar to histone H3 0.015920.11258&radic&radic&radic&radic&radic S000005132KAR1YNL188WverifiedEssential protein involved in karyogamy during mating and inspindle pole body duplication during mitosis,localizes to the half-bridge of the spindlepole body, interacts with Spc72p duringkaryogamy, also interacts with Cdc31p 0.015890.1123&radic&radic&radic S000000112FUS3YBL016WverifiedMitogen-activated protein kinase involved in mating pheromoneresponse; activated by phosphorylation bySte7p; provides specificity during the matingvs. filamentous growth response byphosphorylating transcriptional and cytoplasmictargets 0.015860.11206&radic&radic S000002596CCT6YDR188WverifiedSubunit of the cytosolic chaperonin Cct ring complex, relatedto Tcp1p, essential protein that is requiredfor the assembly of actin and tubulins in vivo;contains an ATP-binding motif 0.01580.11167&radic&radic S000002767VID21YDR359CverifiedComponent of the NuA4 histone acetyltransferase complex 0.015770.11145&radic&radic&radic&radic S000000690CDC50YCR094WverifiedEndosomal protein that regulates cell polarity; similar toYnr048wp and Lem3p 0.015760.11135&radic&radic&radic S000006345KAR3YPR141CverifiedMinus-end-directed microtubule motor that functions in mitosisand meiosis, localizes to the spindle pole bodyand localization is dependent on functionalCik1p, required for nuclear fusion duringmating; potential Cdc28p substrate 0.015720.11113&radic&radic S000004185NMT1YLR195CverifiedN-myristoyl transferase, catalyzes the cotranslational,covalent attachment of myristic acid to theN-terminal glycine residue of several proteinsinvolved in cellular growth and signaltransduction 0.01570.11097&radic&radic&radic&radic S000002104RPL2AYFR031C-AverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl2Bp and has similarity to E.coli L2 and rat L8 ribosomal proteins 0.015680.11088&radic&radic&radic S000005552BUB3YOR026WverifiedKinetochore checkpoint WD40 repeat protein that localizes tokinetochores during prophase and metaphase,delays anaphase in the presence of unattachedkinetochores; forms complexes with Mad1p-Bub1pand with Cdc20p, binds Mad2p and Mad3p 0.015660.11052&radic&radic&radic S000000935GLC7YER133WverifiedCatalytic subunit of type 1 serine/threonine proteinphosphatase, involved in many processesincluding glycogen metabolism, sporulation, andmitosis; interacts with multiple regulatorysubunits; predominantly isolated with Sds22p 0.015620.11022&radic&radic S000005976LGE1YPL055CverifiedProtein of unknown function; null mutant forms abnormally largecells 0.015590.10997&radic&radic&radic S000005475PAP2YOL115WverifiedCatalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), anuclear poly (A) polymerase complex involved inRNA quality control; catalyzes polyadenylationof unmodified tRNAs, and snoRNA and rRNAprecursors; disputed role as a DNA polymerase 0.015550.10953&radic S000005252KRI1YNL308CverifiedEssential nucleolar protein required for 40S ribosomebiogenesis; physically and functionallyinteracts with Krr1p 0.015470.1091&radic&radic&radic&radic S000005293CSE2YNR010WverifiedComponent of the Med9/10 module, which is a subcomplex withinthe RNA polymerase II Mediator complex;required for regulation of RNA polymerase IIactivity 0.015440.10874&radic&radic S000003149GTS1YGL181WverifiedProtein containing a zinc-finger in the N-terminus and a longGln-rich region in the C-terminus; regulatesultradian rhythm, cell size, cell cycle,lifespan, sporulation, heat tolerance, andmultidrug transport 0.015420.10874&radic&radic S000000313CMD1YBR109CverifiedCalmodulin; Ca++ binding protein that regulates Ca++independent processes (mitosis, bud growth,actin organization, endocytosis, etc.) and Ca++dependent processes (stress-activatedpathways), targets include Nuf1p, Myo2p andcalcineurin 0.015420.10874&radic S000003162HOS2YGL194CverifiedHistone deacetylase required for gene activation via specificdeacetylation of lysines in H3 and H4 histonetails; subunit of the Set3 complex, ameiotic-specific repressor of sporulationspecific genes that contains deacetylaseactivity 0.015390.10849&radic&radic&radic&radic S000001014SPO11YHL022CverifiedMeiosis-specific protein that initiates meiotic recombinationby catalyzing the formation of double-strandbreaks in DNA via a transesterificationreaction; required for homologous chromosomepairing and synaptonemal complex formation 0.015330.10787&radic&radic&radic&radic S000005677RPB2YOR151CverifiedRNA polymerase II second largest subunit B150, part of centralcore; similar to bacterial beta subunit 0.01530.10781&radic&radic&radic&radic&radic&radic S000003175SPT16YGL207WverifiedSubunit of the heterodimeric FACT complex (Spt16p-Pob3p),facilitates RNA Polymerase II transcriptionelongation through nucleosomes by destabilizingand then reassembling nucleosome structure 0.01530.10781&radic&radic&radic S000003080TAF6YGL112CverifiedSubunit (60 kDa) of TFIID and SAGA complexes, involved intranscription initiation of RNA polymerase IIand in chromatin modification, similar tohistone H4 0.015250.10749&radic S000001710PAP1YKR002WverifiedPoly(A) polymerase, one of three factors required for mRNA3'-end polyadenylation, forms multiproteincomplex with polyadenylation factor I (PF I),also required for mRNA nuclear export; may alsopolyadenylate rRNAs 0.015270.10749&radic&radic&radic&radic&radic S000003651ASF1YJL115WverifiedNucleosome assembly factor, involved in chromatin assembly anddisassembly, anti-silencing protein that causesderepression of silent loci when overexpressed 0.015210.10729&radic&radic S000003201TAN1YGL232WverifiedPutative tRNA acetyltransferase, RNA-binding protein requiredfor the formation of the modified nucleosideN(4)-acetylcytidine in serine and leucine tRNAsbut not required for the same modification in18S rRNA 0.015190.10721&radic&radic&radic S000001212DBP8YHR169WverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in biogenesis of the 40S ribosomalsubunit 0.015170.1071&radic&radic S000005411GAL11YOL051WverifiedComponent of the Mediator complex; interacts with RNApolymerase II and the general transcriptionfactors to form the RNA polymerase IIholoenzyme; affects transcription by acting astarget of activators and repressors 0.015170.10709&radic&radic&radic S000005168SQS1YNL224CverifiedProtein of unknown function; overexpression antagonizes thesuppression of splicing defects by spp382mutants; green fluorescent protein (GFP)-fusionprotein localizes to both the cytoplasm and thenucleus 0.015140.10675&radic&radic&radic&radic&radic&radic S000000015PSK1YAL017WverifiedOne of two (see also PSK2) PAS domain containing S/T proteinkinases; coordinately regulates proteinsynthesis and carbohydrate metabolism andstorage in response to a unknown metabolitethat reflects nutritional status 0.015150.10675&radic&radic S000005083RLR1YNL139CverifiedSubunit of the THO complex, which is required for efficienttranscription elongation and involved intranscriptional elongation-associatedrecombination; required for LacZ RNA expressionfrom certain plasmids 0.01510.10651&radic&radic S000001499ATP7YKL016CverifiedSubunit d of the stator stalk of mitochondrial F1F0 ATPsynthase, which is a large, evolutionarilyconserved enzyme complex required for ATPsynthesis 0.015090.10635&radic S000004665RNA14YMR061WverifiedCleavage and polyadenylation factor I (CF I) component involvedin cleavage and polyadenylation of mRNA 3'ends; bridges interaction between Rna15p andHrp1p in the CF I complex 0.015050.10615&radic S000003663SPT10YJL127CverifiedPutative histone acetylase, sequence-specific activator ofhistone genes, binds specifically and highlycooperatively to pairs of UAS elements in corehistone promoters, functions at or near theTATA box 0.015030.10599&radic&radic S000005028END3YNL084CverifiedEH domain-containing protein involved in endocytosis, actincytoskeletal organization and cell wallmorphogenesis; forms a complex with Sla1p andPan1p 0.015010.10584 S000003348SPT6YGR116WverifiedEssential protein that interacts with histones and is involvedin nucleosome disassembly and reassembly duringtranscription elongation 0.014850.10474&radic S000005952PHO85YPL031CverifiedCyclin-dependent kinase, with ten cyclin partners; involved inenvironmental stress response; inphosphate-rich conditions, Pho85p-Pho80pcomplex phosphorylates Pho4p which in turnrepresses PHO5 0.014820.10458&radic&radic&radic&radic&radic S000002171HEX3YDL013WverifiedProtein containing a RING finger domain that interacts withSlx8p; mutant phenotypes and geneticinteractions suggest a role in sumoylation andin genome stability 0.014770.1042 S000004223EST1YLR233CverifiedTLC1 RNA-associated factor involved in telomere lengthregulation as the recruitment subunit of thetelomerase holoenzyme, has a possible role inactivating Est2p-TLC1-RNA bound to the telomere 0.014710.10383&radic&radic&radic S000000822GPA2YER020WverifiedNucleotide binding alpha subunit of the heterotrimeric Gprotein that interacts with the receptor Gpr1p,has signaling role in response to nutrients;green fluorescent protein (GFP)-fusion proteinlocalizes to the cell periphery 0.014710.10354&radic&radic S000000787CIN8YEL061CverifiedKinesin motor protein involved in mitotic spindle assembly andchromosome segregation 0.01470.10354&radic S000004660AAC1YMR056CverifiedMitochondrial inner membrane ADP/ATP translocator, exchangescytosolic ADP for mitochondrially synthesizedATP; Aac1p is a minor isoform while Pet9p isthe major ADP/ATP translocator 0.014640.10333 S000003947SSA2YLL024CverifiedATP binding protein involved in protein folding and vacuolarimport of proteins; member of heat shockprotein 70 (HSP70) family; associated with thechaperonin-containing T-complex; present in thecytoplasm, vacuolar membrane and cell wall 0.014590.10289&radic&radic&radic&radic S000003956IRC19YLL033WuncharacterizedPutative protein of unknown function; YLL033W is not anessential gene but mutant is defective in sporeformation; null mutant displays increasedlevels of spontaneous Rad52 foci 0.014580.10289&radic&radic&radic&radic S000002388SSB1YDL229WverifiedCytoplasmic ATPase that is a ribosome-associated molecularchaperone, functions with J-protein partnerZuo1p; may be involved in folding of newly-madepolypeptide chains; member of the HSP70 family;interacts with phosphatase subunit Reg1p 0.014570.10281&radic S000005046POL1YNL102WverifiedCatalytic subunit of the DNA polymerase alpha-primase complex,required for the initiation of DNA replicationduring mitotic DNA synthesis and premeiotic DNAsynthesis 0.014570.10281&radic&radic&radic&radic S000001234CTF8YHR191CverifiedSubunit of a complex with Ctf18p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion 0.014560.10267 S000000435SWC5YBR231CuncharacterizedProtein of unknown function, component of the SWR1 complex,which exchanges histone variant H2AZ (Htz1p)for chromatin-bound histone H2A 0.014540.10263&radic&radic&radic&radic S000002157NHP6BYBR089C-AverifiedHigh-mobility group non-histone chromatin protein, functionallyredundant with Nhp6Ap; homologous to mammalianhigh mobility group proteins 1 and 2; acts torecruit transcription factor Rcs1p to certainpromoters 0.014470.102&radic&radic S000004424IMD3YLR432WverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 0.014470.102&radic S000006394RPC82YPR190CverifiedRNA polymerase III subunit C82 0.014490.102&radic&radic&radic S000001915FAB1YFR019Wverified1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membranekinase that generates phosphatidylinositol(3,5)P2, which is involved in vacuolar sortingand homeostasis 0.014430.10184 S000004093CDC45YLR103CverifiedDNA replication initiation factor; recruited to MCM pre-RCcomplexes at replication origins; promotesrelease of MCM from Mcm10p, recruits elongationmachinery; mutants in human homolog may causevelocardiofacial and DiGeorge syndromes 0.014430.10184&radic&radic&radic&radic S000003643YJL107CUncharacterizedPutative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi 0.014380.10152 S000005437BRX1YOL077CverifiedNucleolar protein, constituent of 66S pre-ribosomal particles;depletion leads to defects in rRNA processingand a block in the assembly of large ribosomalsubunits; possesses a sigma(70)-likeRNA-binding motif 0.014350.10123&radic&radic&radic&radic&radic S000002560ENT5YDR153CverifiedProtein containing an N-terminal epsin-like domain involved inclathrin recruitment and traffic between theGolgi and endosomes; associates with theclathrin adaptor Gga2p, clathrin adaptorcomplex AP-1, and clathrin 0.014290.1009&radic&radic&radic S000000534BIK1YCL029CverifiedMicrotubule-associated protein, component of the interfacebetween microtubules and kinetochore, involvedin sister chromatid separation; essential inpolyploid cells but not in haploid or diploidcells; ortholog of mammalian CLIP-170 0.014280.10079&radic&radic&radic S000001861RIM15YFL033CverifiedGlucose-repressible protein kinase involved in signaltransduction during cell proliferation inresponse to nutrients, specifically theestablishment of stationary phase; originallyidentified as a regulator of IME2 0.014220.10039&radic S000005188SUI1YNL244CverifiedTranslation initiation factor eIF1; component of a complexinvolved in recognition of the initiator codon;modulates translation accuracy at theinitiation phase 0.014210.10037 S000000521DCC1YCL016CverifiedSubunit of a complex with Ctf8p and Ctf18p that shares somecomponents with Replication Factor C, requiredfor sister chromatid cohesion and telomerelength maintenance 0.014210.10037&radic&radic&radic S000001687EAP1YKL204WverifiedeIF4E-associated protein, binds eIF4E and inhibitscap-dependent translation, also functionsindependently of eIF4E to maintain geneticstability; plays a role in cell growth,implicated in the TOR signaling cascade 0.014160.09993&radic S000003412RNR4YGR180CverifiedRibonucleotide-diphosphate reductase (RNR), small subunit; theRNR complex catalyzes the rate-limiting step indNTP synthesis and is regulated by DNAreplication and DNA damage checkpoint pathwaysvia localization of the small subunits 0.014120.09969&radic&radic&radic&radic&radic S000000818BIM1YER016WverifiedMicrotubule-binding protein that together with Kar9p makes upthe cortical microtubule capture site anddelays the exit from mitosis when the spindleis oriented abnormally 0.014080.09934&radic&radic S000004096MDN1YLR106CverifiedHuge dynein-related AAA-type ATPase (midasin), forms extendedpre-60S particle with the Rix1 complex(Rix1p-Ipi1p-Ipi3p), may mediate ATP-dependentremodeling of 60S subunits and subsequentexport from nucleoplasm to cytoplasm 0.014050.0993&radic&radic&radic&radic&radic&radic S000005635INP53YOR109WverifiedPhosphatidylinositol 4,5-bisphosphate 5-phosphatase,synaptojanin-like protein with an N-terminalSac1 domain, plays a role in a TGN (trans Golginetwork)-to-early endosome pathway;hyperosmotic stress causes translocation toactin patches 0.014040.09912&radic S000002419RPL4BYDR012WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl4Ap and has similarity to E.coli L4 and rat L4 ribosomal proteins 0.014020.09894&radic S000005166SSU72YNL222WverifiedTranscription/RNA-processing factor that associates with TFIIBand cleavage/polyadenylation factor Pta1p;exhibits phosphatase activity on serine-5 ofthe RNA polymerase II C-terminal domain;affects start site selection in vivo 0.013990.09866&radic&radic S000003542CYR1YJL005WverifiedAdenylate cyclase, required for cAMP production andcAMP-dependent protein kinase signaling;involved in cell cycle control and glucose andnitrogen repression of sporulation 0.013940.0984 S000005606DIA2YOR080WverifiedOrigin-binding F-box protein that forms an SCF ubiquitin ligasecomplex with Skp1p and Cdc53p; plays a role inDNA replication, involved in invasive andpseudohyphal growth 0.013890.09813&radic S000004683CTF18YMR078CverifiedSubunit of a complex with Ctf8p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion; may have overlappingfunctions with Rad24p in the DNA damagereplication checkpoint 0.013870.09748&radic&radic S000004846YMR233WUncharacterizedProtein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; YMR233W is not an essential gene 0.013820.09748&radic&radic&radic&radic&radic&radic S000001368MOB1YIL106WverifiedComponent of the mitotic exit network; associates with and isrequired for the activation andCdc15p-dependent phosphorylation of the Dbf2pkinase; required for cytokinesis and cellseparation; component of the CCR4transcriptional complex 0.013770.09718&radic S000004388VPS33YLR396CverifiedATP-binding protein that is a subunit of the homotypic vacuolefusion and vacuole protein sorting (HOPS)complex; essential for membrane docking andfusion at both the Golgi-to-endosome andendosome-to-vacuole stages of protein transport 0.013740.09699&radic&radic&radic S000006005BRO1YPL084WverifiedCytoplasmic class E vacuolar protein sorting (VPS) factor thatcoordinates deubiquitination in themultivesicular body (MVB) pathway by recruitingDoa4p to endosomes 0.013740.09699&radic&radic&radic S000002232BRE1YDL074CverifiedE3 ubiquitin ligase for Rad6p, required for the ubiquitinationof histone H2B, recruitment of Rad6p topromoter chromatin and subsequent methylationof histone H3 (on L4 and L79), contains RINGfinger domain 0.01370.09661&radic S000000118PIM1YBL022CverifiedMitochondrial ATP-dependent protease involved inintramitochondrial proteolysis; involved indegradation of misfolded proteins inmitochondria; required for bigenesis andmaintenance of mitochondria 0.01370.09661&radic&radic S000006230ATH1YPR026WverifiedAcid trehalase required for utilization of extracellulartrehalose 0.013720.09661 S000003484GCN5YGR252WverifiedHistone acetyltransferase, acetylates N-terminal lysines onhistones H2B and H3; catalytic subunit of theADA and SAGA histone acetyltransferasecomplexes; founding member of the Gcn5p-relatedN-acetyltransferase superfamily 0.013680.09656&radic&radic S000004339KAP95YLR347CverifiedKaryopherin beta, forms a dimeric complex with Srp1p (Kap60p)that mediates nuclear import of cargo proteinsvia a nuclear localization signal (NLS),interacts with nucleoporins to guide transportacross the nuclear pore complex 0.013660.09641&radic&radic S000001596RAD27YKL113Cverified5' to 3' exonuclease, 5' flap endonuclease, required forOkazaki fragment processing and maturation aswell as for long-patch base-excision repair;member of the S. pombe RAD2/FEN1 family 0.013640.0962&radic&radic&radic&radic S000001160ORC6YHR118CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing; may be phosphorylated by Cdc28p 0.013620.09615&radic&radic&radic&radic&radic&radic S000004190YKE2YLR200WverifiedSubunit of the heterohexameric Gim/prefoldin protein complexinvolved in the folding of alpha-tubulin,beta-tubulin, and actin 0.013620.09615&radic&radic&radic&radic S000002428FAL1YDR021WverifiedNucleolar protein required for maturation of 18S rRNA, memberof the eIF4A subfamily of DEAD-boxATP-dependent RNA helicases 0.013620.09614&radic&radic&radic S000006018MSY1YPL097WverifiedMitochondrial tyrosyl-tRNA synthetase 0.013570.09572&radic&radic S000003740RCY1YJL204CverifiedF-box protein involved in recycling plasma membrane proteinsinternalized by endocytosis; localized to sitesof polarized growth 0.013550.09563&radic&radic&radic&radic S000001709VPS1YKR001CverifiedGTPase required for vacuolar protein sorting, functions inactin cytoskeleton organization via itsinteraction with Sla1p; required for lateGolgi-retention of some proteins includingKex2p; involved in regulating peroxisomebiogenesis 0.013530.09519&radic&radic&radic S000000682CSM1YCR086WverifiedNucleolar protein that forms a complex with Lrs4p which bindsMam1p at kinetochores during meiosis I tomediate accurate chromosome segregation, may beinvolved in premeiotic DNA replication;possible role in telomere maintenance 0.013530.09519&radic S000000147PIN4YBL051CverifiedProtein involved in G2/M phase progression and response to DNAdamage, interacts with Rad53p; contains an RNArecognition motif, a nuclear localizationsignal, and several SQ/TQ cluster domains;hyperphosphorylated in response to DNA damage 0.013490.09479&radic&radic&radic&radic&radic S000004059MEF1YLR069CverifiedMitochondrial elongation factor involved in translationalelongation 0.013420.09431&radic&radic&radic S000004815ERG2YMR202WverifiedC-8 sterol isomerase, catalyzes the isomerization of thedelta-8 double bond to the delta-7 position atan intermediate step in ergosterol biosynthesis 0.013420.09431 S000002651PRP28YDR243CverifiedRNA helicase in the DEAD-box family, involved in RNAisomerization at the 5' splice site 0.013430.09431&radic&radic&radic&radic&radic&radic S000000315YSA1YBR111CverifiedNudix hydrolase family member with ADP-ribose pyrophosphataseactivity 0.013430.09431&radic&radic S000001094CIC1YHR052WverifiedEssential protein that interacts with proteasome components andhas a potential role in proteasome substratespecificity; also copurifies with 66Spre-ribosomal particles 0.013390.09414&radic&radic S000002411RAD57YDR004WverifiedProtein that stimulates strand exchange by stabilizing thebinding of Rad51p to single-stranded DNA;involved in the recombinational repair ofdouble-strand breaks in DNA during vegetativegrowth and meiosis; forms heterodimer withRad55p 0.013350.09402&radic&radic S000002892VPS52YDR484WverifiedComponent of the GARP (Golgi-associated retrograde protein)complex, Vps51p-Vps52p-Vps53p-Vps54p, which isrequired for the recycling of proteins fromendosomes to the late Golgi; involved inlocalization of actin and chitin 0.013330.09381 S000006261BRR1YPR057WverifiedsnRNP protein component of spliceosomal snRNPs, required forpre-mRNA splicing and snRNP biogenesis; in nullmutant newly-synthesized snRNAs aredestabilized and 3'-end processing is slowed 0.013330.09381&radic S000003286YGR054WVerifiedEukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A 0.013320.09368&radic&radic S000004513RSE1YML049CverifiedProtein involved in pre-mRNA splicing; component of thepre-spliceosome; associates with U2 snRNA;involved in ER to Golgi transport 0.013280.09341&radic S000001156BZZ1YHR114WverifiedSH3 domain protein implicated in the regulation of actinpolymerization, able to recruit actinpolymerization machinery through its SH3domains, colocalizes with cortical actinpatches and Las17p, interacts with type Imyosins 0.013240.09306&radic&radic&radic&radic&radic S000003677YAK1YJL141CverifiedSerine-threonine protein kinase that is part of aglucose-sensing system involved in growthcontrol in response to glucose availability;translocates from the cytoplasm to the nucleusand phosphorylates Pop2p in response to aglucose signal 0.013240.09306 S000004365VID22YLR373CverifiedGlycosylated integral membrane protein localized to the plasmamembrane; plays a role infructose-1,6-bisphosphatase (FBPase)degradation; involved in FBPase transport fromthe cytosol to Vid (vacuole import anddegradation) vesicles 0.013160.09255&radic&radic&radic&radic S000000154SHP1YBL058WverifiedUBX (ubiquitin regulatory X) domain-containing protein thatregulates Glc7p phosphatase activity andinteracts with Cdc48p; interacts withubiquitylated proteins in vivo and is requiredfor degradation of a ubiquitylated modelsubstrate 0.013160.09254&radic&radic&radic S000001069RPN1YHR027CverifiedNon-ATPase base subunit of the 19S regulatory particle of the26S proteasome; may participate in therecognition of several ligands of theproteasome; contains a leucine-rich repeat(LRR) domain, a site for protein?proteininteractions 0.013150.09243&radic&radic S000002472YDR065WUncharacterizedProtein of unknown function, required for vacuolar acidification 0.013070.09192&radic&radic&radic S000000755BUD16YEL029CverifiedProtein involved in bud-site selection and telomeremaintenance; diploid mutants display a randombudding pattern instead of the wild-typebipolar pattern; has similarity to pyridoxalkinases 0.013080.09192&radic&radic&radic&radic&radic&radic S000005405PSK2YOL045WverifiedOne of two (see also PSK1) PAS domain containing S/T proteinkinases; regulates sugar flux and translationin response to an unknown metabolite byphosphorylating Ugp1p and Gsy2p (sugar flux)and Caf20p, Tif11p and Sro9p (translation) 0.013060.09169&radic&radic&radic S000005307YNR024WUncharacterizedHypothetical protein 0.013040.09169&radic&radic S000005174ELA1YNL230CverifiedElongin A, F-box protein that forms a heterodimer with Elc1pand participates in transcription elongation 0.012980.09131&radic&radic&radic&radic&radic&radic S000004075ARP6YLR085CverifiedActin-related protein that binds nucleosomes; a component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.012930.09081&radic&radic&radic&radic&radic S000004795SSO2YMR183CverifiedPlasma membrane t-SNARE involved in fusion of secretoryvesicles at the plasma membrane; syntaxinhomolog that is functionally redundant withSso1p 0.012920.09081&radic S000005783CDC31YOR257WverifiedComponent of the spindle pole body (SPB) half-bridge, requiredfor SPB duplication in mitosis and meiosis II;homolog of mammalian centrin; interacts withKar1p 0.012850.0902&radic&radic&radic&radic S000001208PRP8YHR165CverifiedComponent of the U4/U6-U5 snRNP complex, involved in the secondcatalytic step of splicing 0.012840.09009&radic&radic&radic S000000981DMC1YER179WverifiedMeiosis-specific protein required for repair of double-strandbreaks and pairing between homologouschromosomes; homolog of Rad51p and thebacterial RecA protein 0.012770.08957 S000006256NHP6AYPR052CverifiedHigh-mobility group non-histone chromatin protein, functionallyredundant with Nhp6Bp; homologous to mammalianhigh mobility group proteins 1 and 2; acts torecruit transcription factor Rcs1p to certainpromoters 0.012750.08923&radic S000001803MLP1YKR095WverifiedMyosin-like protein associated with the nuclear envelope,connects the nuclear pore complex with thenuclear interior; involved with Tel1p intelomere length control; involved with Pml1pand Pml39p in nuclear retention of unsplicedmRNAs 0.012730.08923&radic S000001210THP2YHR167WverifiedSubunit of the THO complex, which connects transcriptionelongation and mitotic recombination, and ofthe TREX complex, which is recruited toactivated genes and couples transcription tomRNA export; involved in telomere maintenance 0.012740.08923&radic&radic&radic S000004042IES3YLR052WverifiedSubunit of the INO80 chromatin remodeling complex 0.012710.08897&radic S000005670ELG1YOR144CverifiedProtein required for S phase progression and telomerehomeostasis, forms an alternative replicationfactor C complex important for DNA replicationand genome integrity; involved in homologousrecombination-mediated DNA repair 0.012710.08897&radic&radic&radic&radic S000005837NOP58YOR310CverifiedProtein involved in pre-rRNA processing, 18S rRNA synthesis,and snoRNA synthesis; component of the smallsubunit processome complex, which is requiredfor processing of pre-18S rRNA 0.012660.08863&radic&radic&radic S000003679TIM17YJL143WverifiedEssential constituent of the mitochondrial inner membranepresequence translocase; interacts with Pam18pto recruit the presequencetranslocase-associated motor (PAM complex) andalso required for protein sorting during import 0.012590.08797&radic&radic&radic&radic S000005068NAF1YNL124WverifiedProtein required for the assembly of box H/ACA snoRNPs and forpre-rRNA processing, forms a complex with Shq1pand interacts with H/ACA snoRNP componentsNhp2p and Cbf5p; has similarity to Gar1p andother RNA-binding proteins 0.012580.08796&radic S000003013RIM8YGL045WverifiedProtein of unknown function, involved in the proteolyticactivation of Rim101p in response to alkalinepH; has similarity to A. nidulans PalF 0.012570.08787&radic&radic&radic&radic&radic S000005923SNF8YPL002CverifiedComponent of the ESCRT-II complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; appears to be functionallyrelated to SNF7; involved in glucosederepression 0.012540.08733&radic&radic S000002988GET1YGL020CverifiedSubunit of the GET complex; required for the retrieval of HDELproteins from the Golgi to the ER in an ERD2dependent fashion and for normal mitochondrialmorphology and inheritance 0.012550.08733 S000004939YMR320WDubiousHypothetical protein 0.012510.08733&radic S000003712SWI3YJL176CverifiedSubunit of the SWI/SNF chromatin remodeling complex, whichregulates transcription by remodelingchromosomes; required for transcription of manygenes, including ADH1, ADH2, GAL1, HO, INO1 andSUC2 0.012480.08716&radic&radic&radic&radic S000004927YMR310CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene 0.012460.08701&radic&radic&radic&radic S000000416NGR1YBR212WverifiedRNA binding protein that negatively regulates growth rate;interacts with the 3' UTR of the mitochondrialporin (POR1) mRNA and enhances its degradation;overexpression impairs mitochondrial function;expressed in stationary phase 0.012410.08647&radic&radic S000003318PIL1YGR086CverifiedPrimary component of eisosomes, which are large immobile patchstructures at the cell cortex associated withendocytosis, along with Lsp1p and Sur7p; nullmutants show activation of Pkc1p/Ypk1p stressresistance pathways 0.01240.08647 S000001485DID4YKL002WverifiedClass E Vps protein of the ESCRT-III complex, required forsorting of integral membrane proteins intolumenal vesicles of multivesicular bodies, andfor delivery of newly synthesized vacuolarenzymes to the vacuole, involved in endocytosis 0.012370.08617&radic&radic&radic S000002490RRP8YDR083WverifiedNucleolar protein involved in rRNA processing, pre-rRNAcleavage at site A2; also involved in telomeremaintenance; mutation is synthetically lethalwith a gar1 mutation 0.012370.08617&radic&radic&radic&radic&radic&radic S000002600NUP42YDR192CverifiedSubunit of the nuclear pore complex (NPC) that localizesexclusively to the cytoplasmic side; involvedin RNA export, most likely at a terminal step;interacts with Gle1p 0.012380.08617&radic&radic S000001643ELF1YKL160WverifiedTranscription elongation factor that contains a conserved zincfinger domain; implicated in the maintenance ofproper chromatin structure in activelytranscribed regions; deletion inhibits Bromemosaic virus (BMV) gene expression 0.012380.08617&radic&radic&radic S000001873GAT1YFL021WverifiedTranscriptional activator of genes involved in nitrogencatabolite repression, member of the GATAfamily of DNA binding proteins; activity andlocalization regulated by nitrogen limitationand Ure2p 0.01230.08557&radic&radic&radic&radic S000004064BUD20YLR074CverifiedProtein involved in bud-site selection; diploid mutants displaya random budding pattern instead of thewild-type bipolar pattern 0.012250.08521&radic&radic&radic&radic&radic S000005582NOB1YOR056CverifiedEssential nuclear protein involved in proteasome maturation andsynthesis of 40S ribosomal subunits; requiredfor cleavage of the 20S pre-rRNA to generatethe mature 18S rRNA 0.012210.08486&radic&radic&radic&radic&radic S000004086KIN2YLR096WverifiedSerine/threonine protein kinase involved in regulation ofexocytosis; localizes to the cytoplasmic faceof the plasma membrane; closely related toKin1p 0.012210.08486&radic&radic&radic S000005787RPN8YOR261CverifiedEssential, non-ATPase regulatory subunit of the 26S proteasome;has similarity to the human p40 proteasomalsubunit and to another S. cerevisiae regulatorysubunit, Rpn11p 0.012220.08486&radic&radic&radic&radic&radic S000002351ARF1YDL192WverifiedADP-ribosylation factor, GTPase of the Ras superfamily involvedin regulation of coated formation vesicles inintracellular trafficking within the Golgi;functionally interchangeable with Arf2p 0.012210.08486&radic&radic S000002706ATP5YDR298CverifiedSubunit 5 of the stator stalk of mitochondrial F1F0 ATPsynthase, which is a large, evolutionarilyconserved enzyme complex required for ATPsynthesis; homologous to bovine subunit OSCP(oligomycin sensitivity-conferring protein) 0.01220.08483&radic&radic S000005815YOR289WUncharacterizedHypothetical protein 0.012160.08447&radic&radic&radic S000004363ROM2YLR371WverifiedGDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutationsare synthetically lethal with mutations inrom1, which also encodes a GEP 0.012140.08432&radic&radic&radic&radic S000004876SAP30YMR263WverifiedSubunit of a histone deacetylase complex, along with Rpd3p andSin3p, that is involved in silencing attelomeres, rDNA, and silent mating-type loci;involved in telomere maintenance 0.012110.08405&radic&radic&radic&radic S000001894SPB4YFL002CverifiedPutative ATP-dependent RNA helicase, nucleolar protein requiredfor synthesis of 60S ribosomal subunits at alate step in the pathway; sediments with 66Spre-ribosomes in sucrose gradients 0.012090.08364&radic&radic&radic S000004520IMD4YML056CverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 0.012070.08364&radic S000000097ECM15YBL001CverifiedNon-essential protein of unknown function, likely exists astetramer, may be regulated by the binding ofsmall-molecule ligands (possibly sulfate ions),may have a role in yeast cell-wall biogenesis 0.012010.08326&radic&radic&radic&radic S000005667ARP8YOR141CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes 0.012030.08326&radic&radic&radic S000005364SIN3YOL004WverifiedComponent of the Sin3p-Rpd3p histone deacetylase complex,involved in transcriptional repression andactivation of diverse processes, includingmating-type switching and meiosis; involved inthe maintenance of chromosomal integrity 0.012030.08326&radic S000003119NUT1YGL151WverifiedComponent of the RNA polymerase II mediator complex, which isrequired for transcriptional activation andalso has a role in basal transcription 0.011970.08286&radic S000000057YAL061WUncharacterizedputative polyol dehydrogenase 0.011980.08286&radic&radic&radic S000001887BLM10YFL007WverifiedProteosome activator subunit; found in association with coreparticles, with and without the 19S regulatoryparticle; required for resistance to bleomycin,may be involved in protecting against oxidativedamage; similar to mammalian PA200 0.011960.08286&radic&radic&radic&radic&radic S000000533RNQ1YCL028Wverified[PIN(+)] prion, an infectious protein conformation that isgenerally an ordered protein aggregate 0.011930.08257&radic&radic&radic&radic&radic S000005693RPS28AYOR167CverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps28Bp and has similarity to ratS28 ribosomal protein 0.011920.08222&radic&radic&radic S000000733YEL007WUncharacterizedPutative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) 0.011910.08222&radic&radic&radic&radic S000002881PRP3YDR473CverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.011870.08203&radic S000002360TRM8YDL201WverifiedSubunit of a tRNA methyltransferase complex composed of Trm8pand Trm82p that catalyzes 7-methylguanosinemodification of tRNA 0.011860.08193&radic&radic S000005654ADE2YOR128CverifiedPhosphoribosylaminoimidazole carboxylase, catalyzes a step inthe 'de novo' purine nucleotide biosyntheticpathway; red pigment accumulates in mutantcells deprived of adenine 0.011820.08166&radic&radic&radic S000006369RHO1YPR165WverifiedGTP-binding protein of the rho subfamily of Ras-like proteins,involved in establishment of cell polarity;regulates protein kinase C (Pkc1p) and the cellwall synthesizing enzyme 1,3-beta-glucansynthase (Fks1p and Gsc2p) 0.011840.08166&radic&radic S000004847RNH1YMR234WverifiedRibonuclease H1, removes RNA primers during Okazaki fragmentsynthesis; degrades RNA attached to the 5'-endof a DNA strand 0.011830.08166&radic&radic&radic&radic S000000063NUP60YAR002WverifiedSubunit of the nuclear pore complex (NPC), functions to anchorNup2p to the NPC in a process controlled by thenucleoplasmic concentration of Gsp1p-GTP;potential Cdc28p substrate; involved intelomere maintenance 0.011790.0813&radic&radic&radic&radic S000004798HSC82YMR186WverifiedCytoplasmic chaperone of the Hsp90 family, redundant infunction and nearly identical with Hsp82p, andtogether they are essential; expressedconstitutively at 10-fold higher basal levelsthat HSP82 and induced 2-3 fold by heat shock 0.011780.0813&radic&radic&radic&radic S000005180SIN4YNL236WverifiedSubunit of the Mediator complex; interacts with the RNApolymerase II holoenzyme to postively ornegatively regulate transcription; dispensiblefor basal transcription 0.011750.08112&radic&radic&radic&radic S000000662RAD18YCR066WverifiedProtein involved in postreplication repair; bindssingle-stranded DNA and has single-stranded DNAdependent ATPase activity; forms heterodimerwith Rad6p; contains RING-finger motif 0.011760.08112&radic S000006177CLN2YPL256CverifiedG1 cyclin involved in regulation of the cell cycle; activatesCdc28p kinase to promote the G1 to S phasetransition; late G1 specific expression dependson transcription factor complexes, MBF(Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) 0.011750.08109&radic&radic&radic&radic S000002865TOM1YDR457WverifiedE3 ubiquitin ligase of the hect-domain class; has a role inmRNA export from the nucleus and may regulatetranscriptional coactivators 0.011750.08109&radic&radic S000002537FIN1YDR130CverifiedSpindle pole body-related intermediate filament protein, formscell cycle-specific filaments between spindlepole bodies in mother and daughter cells, ableto self-assemble, expression induced duringS/G2, localization cell-cycle dependent 0.011750.08109&radic&radic&radic S000002527TRM1YDR120CverifiedtRNA methyltransferase, localizes to both the nucleus andmitochondrion to produce the modified baseN2,N2-dimethylguanosine in tRNAs in bothcompartments 0.011710.08078&radic&radic&radic&radic&radic S000001073RRM3YHR031CverifiedDNA helicase involved in rDNA replication and Ty1transposition; relieves replication fork pausesat telomeric regions; structurally andfunctionally related to Pif1p 0.011690.08056&radic&radic&radic&radic&radic S000000568VAC17YCL063WverifiedProtein involved in vacuole inheritance; acts as avacuole-specific receptor for myosin Myo2p 0.011630.08014&radic&radic S000004391BDF1YLR399CverifiedProtein involved in transcription initiation at TATA-containingpromoters; associates with the basaltranscription factor TFIID; contains twobromodomains; corresponds to the C-terminalregion of mammalian TAF1; redundant with Bdf2p 0.011610.07993&radic&radic&radic&radic&radic S000006255MAK3YPR051WverifiedCatalytic subunit of N-terminal acetyltransferase of the NatCtype; required for replication of dsRNA virus 0.011570.07969&radic&radic S000002731PEP7YDR323CverifiedMultivalent adaptor protein that facilitates vesicle-mediatedvacuolar protein sorting by ensuringhigh-fidelity vesicle docking and fusion, whichare essential for targeting of vesicles to theendosome; required for vacuole inheritance 0.011540.07937&radic&radic&radic S000003446RPS0AYGR214WverifiedProtein component of the small (40S) ribosomal subunit, nearlyidentical to Rps0Bp; required for maturation of18S rRNA along with Rps0Bp; deletion of eitherRPS0 gene reduces growth rate, deletion of bothgenes is lethal 0.011510.07918&radic&radic&radic S000003968RPL8BYLL045CverifiedRibosomal protein L4 of the large (60S) ribosomal subunit,nearly identical to Rpl8Ap and has similarityto rat L7a ribosomal protein; mutation resultsin decreased amounts of free 60S subunits 0.011510.07918&radic&radic&radic&radic S000002598RVB1YDR190CverifiedEssential protein involved in transcription regulation;component of chromatin remodeling complexes;required for assembly and function of the INO80complex; member of the RUVB-like protein family 0.011520.07918&radic&radic&radic&radic S000004254RPS28BYLR264WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps28Ap and has similarity to ratS28 ribosomal protein 0.011510.07918&radic&radic&radic&radic S000001612MYO3YKL129CverifiedOne of two type I myosins; localizes to actin cortical patches;deletion of MYO3 has little effect on growth,but myo3 myo5 double deletion causes severedefects in growth and actin cytoskeletonorganization 0.011510.0791&radic&radic&radic S000005256RFA2YNL312WverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 0.011460.0787&radic&radic&radic S000000302MMS4YBR098WverifiedSubunit of the structure-specific Mms4p-Mus81p endonucleasethat cleaves branched DNA; involved inrecombination and DNA repair 0.011460.0787&radic&radic S000004467ERG6YML008CverifiedDelta(24)-sterol C-methyltransferase, converts zymosterol tofecosterol in the ergosterol biosyntheticpathway by methylating position C-24; localizedto both lipid particles and mitochondrial outermembrane 0.011430.07847&radic S000000393RPS9BYBR189WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps9Ap and has similarity to E.coli S4 and rat S9 ribosomal proteins 0.01140.07798&radic&radic S000003212TAD1YGL243WverifiedtRNA-specific adenosine deaminase, deaminates adenosine-37 toinosine in tRNA-Ala 0.01140.07798&radic&radic S000003726RPS22AYJL190CverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps22Bp and has similarity to E.coli S8 and rat S15a ribosomal proteins 0.011410.07798&radic&radic&radic&radic S000004621STB4YMR019WverifiedProtein that binds Sin3p in a two-hybrid assay; contains aZn(II)2Cys6 zinc finger domain characteristicof DNA-binding proteins 0.011350.07776&radic&radic S000003290YGR058WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 0.011360.07776&radic&radic&radic S000001305CBR1YIL043CverifiedMicrosomal cytochrome b reductase, not essential for viability;also detected in mitochondria; mutation inconserved NADH binding domain of the humanortholog results in type I methemoglobinemia 0.011290.07731&radic&radic&radic S000005337ESF2YNR054CverifiedEssential nucleolar protein involved in pre-18S rRNAprocessing; component of the small subunit(SSU) processome; has sequence similarity tomABT1, a mouse transcription activator 0.011290.07731&radic&radic&radic S000000743GTT3YEL017WuncharacterizedProtein of unknown function with a possible role in glutathionemetabolism, as suggested by computationalanalysis of large-scale protein-proteininteraction data; GFP-fusion protein localizesto the nuclear periphery 0.011290.07729&radic&radic&radic&radic&radic S000005032TOP2YNL088WverifiedEssential type II topoisomerase, relieves torsional strain inDNA by cleaving and re-sealing thephosphodiester backbone of both positively andnegatively supercoiled DNA; cleavescomplementary strands; localizes to axial coresin meiosis 0.011260.07704&radic S000001047GPA1YHR005CverifiedGTP-binding alpha subunit of the heterotrimeric G protein thatcouples to pheromone receptors; negativelyregulates the mating pathway by sequesteringG(beta)gamma and by triggering an adaptiveresponse; activates Vps34p at the endosome 0.011260.07704 S000001115OSH3YHR073WverifiedMember of an oxysterol-binding protein family with sevenmembers in S. cerevisiae; family members haveoverlapping, redundant functions in sterolmetabolism and collectively perform a functionessential for viability 0.011250.07694&radic&radic&radic&radic S000004710YPK2YMR104CverifiedProtein kinase with similarityto serine/threonine proteinkinase Ypk1p; functionally redundant with YPK1at the genetic level; participates in asignaling pathway required for optimal cellwall integrity; homolog of mammalian kinase SGK 0.011250.07694&radic&radic S000006290SUA7YPR086WverifiedTranscription factor TFIIB, a general transcription factorrequired for transcription initiation and startsite selection by RNA polymerase II 0.011220.07681&radic&radic S000003770SPC1YJR010C-AverifiedSubunit of the signal peptidase complex (SPC), which cleavesthe signal sequence from proteins targeted tothe endoplasmic reticulum (ER), homolog of theSPC12 subunit of mammalian signal peptidasecomplex 0.011230.07681 S000005642RPO31YOR116CverifiedRNA polymerase III subunit C160, part of core enzyme; similarto bacterial beta-prime subunit 0.011230.07681&radic&radic&radic S000000165AST1YBL069WverifiedPeripheral membrane protein that interacts with the plasmamembrane ATPase Pma1p and has a role in itstargeting to the plasma membrane, possibly byinfluencing its incorporation into lipid rafts 0.01120.0766&radic&radic&radic&radic&radic S000005760RPL33BYOR234CverifiedRibosomal protein L37 of the large (60S) ribosomal subunit,nearly identical to Rpl33Ap and has similarityto rat L35a; rpl33b null mutant exhibits normalgrowth while rpl33a rpl33b double null mutantis inviable 0.01120.0766&radic&radic&radic&radic S000005107RIA1YNL163CverifiedCytoplasmic GTPase involved in biogenesis of the 60S ribosome;has similarity to translation elongation factor2 (Eft1p and Eft2p) 0.011190.07653&radic&radic&radic&radic S000000159KIP1YBL063WverifiedKinesin-related motor protein required for mitotic spindleassembly and chromosome segregation;functionally redundant with Cin8p 0.011190.07653&radic S000001005OTU2YHL013CverifiedProtein of unknown function that may interact with ribosomes,based on co-purification experiments; member ofthe ovarian tumor-like (OTU) superfamily ofpredicted cysteine proteases; shows cytoplasmiclocalization 0.011180.0765&radic&radic S000004559GIM5YML094WverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.011160.07625&radic S000000120NCL1YBL024WverifiedS-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase,methylates cytosine to m5C at several positionsin tRNAs and intron-containing pre-tRNAs;similar to Nop2p and human proliferationassociated nucleolar protein p120 0.011130.07611&radic&radic&radic S000005036YNL092WUncharacterizedPutative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene 0.01110.07577&radic S000001346SDS3YIL084CverifiedComponent of the Rpd3p/Sin3p deacetylase complex required forits structural integrity and catalyticactivity, involved in transcriptional silencingand required for sporulation; cells defectivein SDS3 display pleiotropic phenotypes 0.011090.07577&radic&radic&radic S000001197RTT107YHR154WverifiedProtein implicated in Mms22-dependent DNA repair during Sphase, DNA damage induces phosphorylation byMec1p at one or more SQ/TQ motifs; interactswith Mms22p and Slx4p; has four BRCT domains;has a role in regulation of Ty1 transposition 0.011090.07577&radic&radic&radic S000004280GUF1YLR289WverifiedMitochondrial GTPase of unknown function, similar to E. colielongation factor-type GTP-binding protein LepAand to LK1236.1 from Caenorhabditis elegans 0.011020.07522&radic&radic&radic&radic S000004085IOC2YLR095CverifiedMember of a complex (Isw1b) with Isw1p and Ioc4p that exhibitsnucleosome-stimulated ATPase activity and actswithin coding regions to coordinatetranscription elongation with termination andprocessing, contains a PHD finger motif 0.011040.07522&radic&radic&radic&radic&radic&radic S000003450CRM1YGR218WverifiedMajor karyopherin, involved in export of proteins, RNAs, andribosomal subunits from the nucleus 0.011030.07522&radic&radic&radic S000001524VPS24YKL041WverifiedOne of four subunits of the endosomal sorting complex requiredfor transport III (ESCRT-III); forms anESCRT-III subcomplex with Did4p; involved inthe sorting of transmembrane proteins into themultivesicular body (MVB) pathway 0.0110.07507 S000005553STI1YOR027WverifiedHsp90 cochaperone, interacts with the Ssa group of thecytosolic Hsp70 chaperones; activates theATPase activity of Ssa1p; homolog of mammalianHop protein 0.010980.07487&radic&radic&radic&radic&radic S000004310EST2YLR318WverifiedReverse transcriptase subunit of the telomerase holoenzyme,essential for telomerase core catalyticactivity, involved in other aspects oftelomerase assembly and function; mutations inhuman homolog are associated with aplasticanemia 0.010940.07464&radic S000002385GCS1YDL226CverifiedADP-ribosylation factor GTPase activating protein (ARF GAP),involved in ER-Golgi transport; sharesfunctional similarity with Glo3p 0.010920.07445&radic S000002772CDC40YDR364CverifiedPre-mRNA splicing factor, important for catalytic step II ofpre-mRNA splicing and plays a role in cellcycle progression; required for DNA synthesisduring mitosis and meiosis; has WD repeats 0.010930.07445&radic&radic&radic&radic&radic S000004908JNM1YMR294WverifiedComponent of the yeast dynactin complex, consisting of Nip100p,Jnm1p, and Arp1p; required for proper nuclearmigration and spindle partitioning duringmitotic anaphase B 0.010910.07445&radic S000004479PSP2YML017WverifiedAsn rich cytoplasmic protein that contains RGG motifs;high-copy suppressor of group IIintron-splicing defects of a mutation in MRS2and of a conditional mutation in POL1 (DNApolymerase alpha); possible role inmitochondrial mRNA splicing 0.010880.07407&radic&radic S000004385ATP10YLR393WverifiedMitochondrial inner membrane protein required for assembly ofthe F0 sector of mitochondrial F1F0 ATPsynthase, interacts genetically with ATP6 0.010860.07407&radic&radic S000003310PAC10YGR078CverifiedPart of the heteromeric co-chaperone GimC/prefoldin complex,which promotes efficient protein folding 0.010890.07407&radic&radic&radic&radic S000000379SWD3YBR175WverifiedEssential subunit of the COMPASS (Set1C) complex, whichmethylates histone H3 on lysine 4 and isrequired in transcriptional silencing neartelomeres; WD40 beta propeller superfamilymember and ortholog of mammalian WDR5 0.010880.07407&radic&radic&radic&radic&radic S000005241MON2YNL297CverifiedPeripheral membrane protein with a role in endocytosis andvacuole integrity, interacts with Arl1p andlocalizes to the endosome; member of the Sec7pfamily of proteins 0.010870.07407 S000003336SRB5YGR104CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation; involved intelomere maintenance 0.010840.07391&radic&radic&radic S000001787TRZ1YKR079CverifiedtRNase Z, involved in RNA processing, has two putativenucleotide triphosphate-binding motifs (P-loop)and a conserved histidine motif, homolog of thehuman candidate prostate cancer susceptibilitygene ELAC2 0.010840.07391&radic&radic&radic S000001733RPC37YKR025WverifiedRNA polymerase III subunit C37 0.010820.07349&radic&radic&radic&radic&radic S000005487RPL25YOL127WverifiedPrimary rRNA-binding ribosomal protein component of the large(60S) ribosomal subunit, has similarity to E.coli L23 and rat L23a ribosomal proteins; bindsto 26S rRNA via a conserved C-terminal motif 0.010820.07349 S000002744YDR336WUncharacterizedPutative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene 0.01080.07349&radic&radic S000004811CIK1YMR198WverifiedKinesin-associated protein required for both karyogamy andmitotic spindle organization, interacts stablyand specifically with Kar3p and may function totarget this kinesin to a specific cellularrole; has similarity to Vik1p 0.010770.07334 S000005721SLK19YOR195WverifiedKinetochore-associated protein required for normal segregationof chromosomes in meiosis and mitosis;component of the FEAR regulatory network, whichpromotes Cdc14p release from the nucleolusduring anaphase; potential Cdc28p substrate 0.010760.07332&radic&radic&radic S000006359NCA2YPR155CverifiedProtein involved in regulation of mitochondrial expression ofsubunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1ATP synthase; functions with Nca3p 0.010760.07323&radic&radic&radic&radic S000000284SEC18YBR080CverifiedATPase required for the release of Sec17p during the 'priming'step in homotypic vacuole fusion and for ER toGolgi transport; homolog of the mammalian NSF 0.010740.07299 S000004836UBP8YMR223WverifiedUbiquitin-specific protease that is a component of the SAGA(Spt-Ada-Gcn5-Acetyltransferase) acetylationcomplex; required for SAGA-mediateddeubiquitination of histone H2B 0.010740.07299&radic&radic&radic&radic S000005739SAS5YOR213CverifiedSubunit of the SAS complex (Sas2p, Sas4p, Sas5p), whichacetylates free histones and nucleosomes andregulates transcriptional silencing; stimulatesSas2p HAT activity 0.010720.0729&radic&radic&radic&radic&radic&radic S000003485PUP2YGR253CverifiedAlpha subunit of the 20S proteasome involved inubiquitin-dependent catabolism; human homologis subunit zeta 0.010690.07275&radic&radic&radic&radic S000002776YPR1YDR368Wverified2-methylbutyraldehyde reductase, may be involved in isoleucinecatabolism 0.010710.07275&radic&radic&radic&radic&radic S000004334FKS1YLR342WverifiedCatalytic subunit of 1,3-beta-D-glucan synthase, functionallyredundant with alternate catalytic subunitGsc2p; binds to regulatory subunit Rho1p;involved in cell wall synthesis andmaintenance; localizes to sites of cell wallremodeling 0.010670.07257&radic S000005209IST1YNL265CverifiedPutative translation initiation factor, as suggested bycomputational analysis of large-scaleprotein-protein interaction data 0.010590.072&radic S000004527MFT1YML062CverifiedSubunit of the THO complex, which is a nuclear complexcomprised of Hpr1p, Mft1p, Rlr1p, and Thp2p,that is involved in transcription elongationand mitotic recombination; involved in telomeremaintenance 0.010570.07183&radic S000002491TVP23YDR084CuncharacterizedIntegral membrane protein localized to late Golgi vesiclesalong with the v-SNARE Tlg2p; green fluorescentprotein (GFP)-fusion protein localizes to thecytoplasm in a punctate pattern 0.010580.07183&radic&radic&radic S000004038RPS0BYLR048WverifiedProtein component of the small (40S) ribosomal subunit, nearlyidentical to Rps0Ap; required for maturation of18S rRNA along with Rps0Ap; deletion of eitherRPS0 gene reduces growth rate, deletion of bothgenes is lethal 0.010530.07161&radic&radic&radic&radic S000001049ERG11YHR007CverifiedLanosterol 14-alpha-demethylase, catalyzes the C-14demethylation of lanosterol to form4,4''-dimethylcholesta-8,14,24-triene-3-beta-ol in theergosterol biosynthesis pathway; member of thecytochrome P450 family 0.010530.07161&radic&radic S000002732UTP4YDR324CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.01050.0713&radic&radic&radic&radic S000001789RPF2YKR081CverifiedEssential protein involved in the processing of pre-rRNA andthe assembly of the 60S ribosomal subunit;interacts with ribosomal protein L11; localizespredominantly to the nucleolus; constituent of66S pre-ribosomal particles 0.010470.07113&radic&radic&radic&radic&radic&radic S000002470YDR063WUncharacterizedHypothetical protein 0.010440.07086&radic&radic&radic&radic&radic S000001297CKA1YIL035CverifiedAlpha catalytic subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA2, CKB1 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.010440.07086&radic&radic&radic&radic&radic S000001897LOC1YFR001WverifiedNuclear protein involved in asymmetric localization of ASH1mRNA; binds double-stranded RNA in vitro;constituent of 66S pre-ribosomal particles 0.010450.07086&radic&radic&radic&radic&radic S000004464TRM12YML005WverifiedS-adenosylmethionine-dependent methyltransferase of the sevenbeta-strand family; required for wybutosineformation in phenylalanine-accepting tRNA 0.010460.07086&radic&radic S000005996GCR1YPL075WverifiedTranscriptional activator of genes involved in glycolysis;DNA-binding protein that interacts andfunctions with the transcriptional activatorGcr2p 0.01040.07062&radic&radic&radic&radic S000004186PWP1YLR196WverifiedProtein with WD-40 repeats involved in rRNA processing;associates with trans-acting ribosomebiogenesis factors; similar to beta-transducinsuperfamily 0.010370.07045&radic&radic&radic&radic&radic&radic&radic S000001410RPL40AYIL148WverifiedFusion protein, identical to Rpl40Bp, that is cleaved to yieldubiquitin and a ribosomal protein of the large(60S) ribosomal subunit with similarity to ratL40; ubiquitin may facilitate assembly of theribosomal protein into ribosomes 0.010380.07045&radic&radic S000001498PUT3YKL015WverifiedTranscriptional activator of proline utilization genes,constitutively binds PUT1 and PUT2 promotersequences and undergoes a conformational changeto form the active state; has a Zn(2)-Cys(6)binuclear cluster domain 0.010360.07037&radic&radic&radic&radic S000004057PET309YLR067CverifiedSpecific translational activator for the COX1 mRNA, alsoinfluences stability of intron-containing COX1primary transcripts; located in themitochondrial inner membrane 0.010350.07037&radic&radic&radic S000002722RAD34YDR314CverifiedProtein involved in nucleotide excision repair (NER);homologous to RAD4 0.01030.07001&radic&radic&radic&radic S000005222CAF120YNL278WverifiedPart of the evolutionarily-conserved CCR4-NOT transcriptionalregulatory complex involved in controlling mRNAinitiation, elongation, and degradation 0.010270.06985&radic&radic&radic&radic&radic S000005750RPB8YOR224CverifiedRNA polymerase subunit ABC14.5, common to RNA polymerases I,II, and III 0.010250.06957&radic&radic&radic&radic S000005153SSB2YNL209WverifiedCytoplasmic ATPase that is a ribosome-associated molecularchaperone, functions with J-protein partnerZuo1p; may be involved in the folding ofnewly-synthesized polypeptide chains; member ofthe HSP70 family; homolog of SSB1 0.010230.06957&radic S000002379CDC13YDL220CverifiedSingle stranded DNA-binding protein found at TG1-3 telomereG-tails; regulates telomere replication throughrecruitment of specific sub-complexes, but theessential function is telomere capping 0.010230.06957&radic&radic S000001310NEO1YIL048WverifiedProtein involved in the retrograde transport from the Golgicomplex to the ER and the endosomal membranetraffic; putative aminophospholipidtranslocase; member of the highly conservedDrs2 family of P-type ATPases 0.010260.06957&radic S000002383WHI4YDL224CverifiedPutative RNA binding protein and partially redundant Whi3phomolog that regulates the cell sizerequirement for passage through Start andcommitment to cell division 0.010220.06927&radic&radic S000001693UBA1YKL210WverifiedUbiquitin activating enzyme, involved in ubiquitin-mediatedprotein degradation and essential for viability 0.010210.06927&radic&radic&radic S000001126STE12YHR084WverifiedTranscription factor that is activated by a MAP kinasesignaling cascade, activates genes involved inmating or pseudohyphal/invasive growthpathways; cooperates with Tec1p transcriptionfactor to regulate genes specific for invasivegrowth 0.010220.06927&radic S000003577NSP1YJL041WverifiedEssential component of the nuclear pore complex, which mediatesnuclear import and export 0.010180.06918 S000000017FUN30YAL019WverifiedProtein whose overexpression affects chromosome stability,potential Cdc28p substrate; homolog of Snf2p;the authentic, non-tagged protein is detectedin highly purified mitochondria inhigh-throughput studies 0.010180.06918&radic&radic&radic&radic S000004533ITT1YML068WverifiedProtein that modulates the efficiency of translationtermination, interacts with translation releasefactors eRF1 (Sup45p) and eRF3 (Sup35p) invitro, contains a zinc finger domaincharacteristic of the TRIAD class of proteins 0.010180.06918 S000004682VPS20YMR077CverifiedMyristoylated subunit of ESCRTIII, the endosomal sortingcomplex required for transport of transmembraneproteins into the multivesicular body pathwayto the lysosomal/vacuolar lumen; cytoplasmicprotein recruited to endosomal membranes 0.010160.06903 S000003999RLP24YLR009WverifiedRibosomal Like Protein 24 0.010150.06903&radic&radic S000003906RPS4AYJR145CverifiedProtein component of the small (40S) ribosomal subunit;mutation affects 20S pre-rRNA processing;identical to Rps4Bp and has similarity to ratS4 ribosomal protein 0.010160.06903&radic S000003809CYC1YJR048WverifiedCytochrome c, isoform 1; electron carrier of the mitochondrialintermembrane space that transfers electronsfrom ubiquinone-cytochrome c oxidoreductase tocytochrome c oxidase during cellularrespiration 0.010130.06886&radic&radic S000000130STU1YBL034CverifiedComponent of the mitotic spindle that binds to interpolarmicrotubules via its association withbeta-tubulin (Tub2p); required for interpolarmicrotubules to provide an outward force on thespindle poles 0.010140.06886&radic&radic S000003802URB2YJR041CverifiedNucleolar protein required for normal metabolism of the rRNAprimary transcript, proposed to be involved inribosome biogenesis 0.010140.06886&radic S000003095SOH1YGL127CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; involved in telomeremaintenance; conserved with other metazoanMED31 subunits 0.010110.06871&radic S000000973RAD3YER171Wverified5' to 3' DNA helicase, involved in nucleotide excision repairand transcription; subunit of RNA polymerase IItranscription initiation factor TFIIH; subunitof Nucleotide Excision Repair Factor 3 (NEF3);homolog of human XPD protein 0.010110.06871&radic&radic S000005580VHS3YOR054CverifiedFunctionally redundant (see also SIS2) inhibitory subunit ofPpz1p, a PP1c-related ser/thr proteinphosphatase Z isoform; synthetically lethalwith sis2; putative phosphopantothenoylcysteinedecarboxylase involved in coenzyme Abiosynthesis 0.010110.06871&radic&radic&radic S000006365SGV1YPR161CverifiedCyclin (Bur2p)-dependent protein kinase that functions intranscriptional regulation; phosphorylates thecarboxy-terminal domain of Rpo21p, which is thelargest subunit of RNA polymerase II; regulatedby Cak1p 0.010070.06846&radic&radic S000001497URB1YKL014CverifiedNucleolar protein required for the normal accumulation of 25Sand 5.8S rRNAs, associated with the 27SA2pre-ribosomal particle; proposed to be involvedin the biogenesis of the 60S ribosomal subunit 0.010040.06834&radic&radic&radic S000005030YNL086WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to endosomes 0.010040.06834 S000002459DBF4YDR052CverifiedRegulatory subunit of Cdc7p-Dbf4p kinase complex, required forCdc7p kinase activity and initiation of DNAreplication; phosphorylates the Mcm2-7 familyof proteins; cell cycle regulated 0.010010.06812&radic&radic&radic&radic S000003566VPS53YJL029CverifiedComponent of the GARP (Golgi-associated retrograde protein)complex, Vps51p-Vps52p-Vps53p-Vps54p, which isrequired for the recycling of proteins fromendosomes to the late Golgi; required forvacuolar protein sorting 0.010.06793 S000002790RPP2BYDR382WverifiedRibosomal protein P2 beta, a component of the ribosomal stalk,which is involved in the interaction betweentranslational elongation factors and theribosome; regulates the accumulation of P1(Rpp1Ap and Rpp1Bp) in the cytoplasm 0.009990.06793&radic&radic S000006041VPS30YPL120WverifiedProtein that forms a membrane-associated complex with Apg14pthat is essential for autophagy; involved in aretrieval step of the carboxypeptidase Yreceptor, Vps10p, to the late Golgi from theendosome; involved in vacuolar protein sorting 0.009980.06793&radic&radic S000005849LDB19YOR322CverifiedProtein of unknown function involved in maintenance of propertelomere length; null mutant shows a reducedaffinity for the alcian blue dye suggesting adecreased net negative charge of the cellsurface 0.009980.06793&radic&radic&radic&radic S000003180VAM7YGL212WverifiedComponent of the vacuole SNARE complex involved in vacuolarmorphogenesis; SNAP-25 homolog; functions witha syntaxin homolog Vam3p in vacuolar proteintrafficking 0.009970.06782&radic&radic&radic&radic S000001734GCN3YKR026CverifiedAlpha subunit of the translation initiation factor eIF2B, theguanine-nucleotide exchange factor for eIF2;activity subsequently regulated byphosphorylated eIF2; first identified as apositive regulator of GCN4 expression 0.00990.0674&radic&radic&radic S000005126IPI3YNL182CuncharacterizedProtein required for cell viability; computational analysis oflarge-scale protein-protein interaction datasuggests a possible role in assembly of theribosomal large subunit 0.00990.0674&radic&radic&radic S000005383IFM1YOL023WverifiedMitochondrial translation initiation factor 2 0.00990.0674&radic&radic&radic S000005391SIL1YOL031CverifiedNucleotide exchange factor for the endoplasmic reticulum (ER)lumenal Hsp70 chaperone Kar2p, required forprotein translocation into the ER; homolog ofYarrowia lipolytica SLS1; GrpE-like protein 0.009920.0674&radic S000004239YEF3YLR249WverifiedTranslational elongation factor, stimulates the binding ofaminoacyl-tRNA (AA-tRNA) to ribosomes byreleasing EF-1 alpha from the ribosomalcomplex; contains two ABC cassettes; binds andhydrolyses ATP 0.009920.0674&radic&radic&radic&radic S000001764TRM2YKR056WverifiedtRNA methyltransferase, 5-methylates the uridine residue atposition 54 of tRNAs and may also have a rolein tRNA stabilization or maturation; previouslythought to be an endo-exonuclease 0.009880.0672&radic&radic S000002298SCM3YDL139CuncharacterizedProtein of unknown function; isolated as a high-copy suppressorof mutations in the histone fold domain (HFD)of CSE4 0.009890.0672&radic&radic&radic S000001232PTH1YHR189WverifiedOne of two (see also PTH2) mitochondrially-localizedpeptidyl-tRNA hydrolases; dispensable for cellgrowth and for mitochondrial respiration 0.009860.06718&radic&radic&radic S000005199GIS2YNL255CverifiedProtein with seven cysteine-rich CCHC zinc-finger motifs,similar to human CNBP, proposed to be involvedin the RAS/cAMP signaling pathway 0.009860.06718&radic&radic&radic&radic&radic&radic S000000171SSA3YBL075CverifiedATPase involved in protein folding and the response to stress;plays a role in SRP-dependent cotranslationalprotein-membrane targeting and translocation;member of the heat shock protein 70 (HSP70)family; localized to the cytoplasm 0.009840.06704&radic&radic&radic S000005820RRS1YOR294WverifiedEssential protein that binds ribosomal protein L11 and isrequired for nuclear export of the 60Spre-ribosomal subunit during ribosomebiogenesis; mouse homolog shows alteredexpression in Huntington's disease model mice 0.009840.06704&radic&radic&radic S000002456YDR049WUncharacterizedZinc finger protein; putative transcription factor that may interact with proteins involved in histone acetylation or deacetylation; may be involved in altering acetylation on histone lysines 0.009820.06686&radic&radic&radic S000005968SGF11YPL047WverifiedIntegral subunit of SAGA histone acetyltransferase complex,regulates transcription of a subset ofSAGA-regulated genes, required for the Ubp8passociation with SAGA and for H2Bdeubiquitylation 0.009810.06686&radic&radic&radic&radic&radic S000005988YPL067CUncharacterizedHypothetical protein 0.009810.06686&radic&radic&radic S000000514STP22YCL008CverifiedComponent of the ESCRT-I complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; homologous to the mouse and humanTsg101 tumor susceptibility gene; mutantsexhibit a Class E Vps phenotype 0.009690.06608&radic&radic S000006377VPS4YPR173CverifiedAAA-type ATPase required for efficient late endosome to vacuoletransport; catalyzes the release of anendosomal membrane-associated class E VPSprotein complex; regulates cellular sterolmetabolism; cytoplasmic and endosomallocalization 0.00970.06608&radic&radic S000003700TPK1YJL164CverifiedSubunit of cytoplasmic cAMP-dependent protein kinase, whichcontains redundant catalytic subunits Tpk1p,Tpk2p, and Tpk3p and regulatory subunit Bcy1p;promotes vegetative growth in response tonutrients; inhibits filamentous growth 0.009660.06592&radic&radic&radic S000006432EST3YIL009C-AverifiedComponent of the telomerase holoenzyme, involved in telomerereplication 0.009650.06585 S000002219RPS29BYDL061CverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps29Ap and has similarity to ratS29 and E. coli S14 ribosomal proteins 0.009650.06585&radic S000001340THS1YIL078WverifiedThreonyl-tRNA synthetase, essential cytoplasmic protein 0.009640.06577&radic&radic&radic&radic S000001786YKR078WVerifiedCytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) 0.009640.06577&radic&radic&radic S000000033FUN12YAL035WverifiedGTPase, required for general translation initiation bypromoting Met-tRNAiMet binding to ribosomes andribosomal subunit joining; homolog of bacterialIF2 0.009630.06561&radic&radic&radic S000003583RTT101YJL047CverifiedCullin subunit of a Roc1p-dependent E3 ubiquitin ligasecomplex; deletion phenotype suggests a role inanaphase progression; interacts with Mms22p andimplicated in Mms22-dependent DNA repair;modified by the ubiquitin-like protein, Rub1p 0.009620.06561&radic&radic S000003954GPI13YLL031CverifiedER membrane localized phosphoryltransferase that addsphosphoethanolamine onto the third mannoseresidue of the glycosylphosphatidylinositol(GPI) anchor precursor; similar to human PIG-Oprotein 0.009630.06561&radic&radic S000002797SAC7YDR389WverifiedGTPase activating protein (GAP) for Rho1p, involved insignaling to the actin cytoskeleton, nullmutations suppress tor2 mutations andtemperature sensitive mutations in actin;potential Cdc28p substrate 0.009610.06558&radic&radic&radic S000002864NHX1YDR456WverifiedEndosomal Na+/H+ exchanger, required for intracellularsequestration of Na+; required forosmotolerance to acute hypertonic shock 0.00960.06556 S000003065SRM1YGL097WverifiedNucleotide exchange factor for Gsp1p, localizes to the nucleus,required for nucleocytoplasmic trafficking ofmacromolecules; potentially phosphorylated byCdc28p 0.009570.06533&radic S000004216BUR2YLR226WverifiedCyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2pcomprise a CDK-cyclin complex involved intranscriptional regulation through itsphosphorylation of the carboxy-terminal domainof the largest subunit of RNA polymerase II 0.009570.06533&radic&radic&radic S000005051YAF9YNL107WverifiedSubunit of both the NuA4 histone H4 acetyltransferase complexand the SWR1 complex, may function toantagonize silencing near telomeres; interactsdirectly with Swc4p, has homology to humanleukemogenic protein AF9, contains a YEATSdomain 0.00960.06533&radic&radic&radic S000005659EFT1YOR133WverifiedElongation factor 2 (EF-2), also encoded by EFT2; catalyzesribosomal translocation during proteinsynthesis; contains diphthamide, the uniqueposttranslationally modified histidine residuespecifically ADP-ribosylated by diphtheriatoxin 0.009540.06511&radic&radic&radic&radic S000002178RPN4YDL020CverifiedTranscription factor that stimulates expression of proteasomegenes; Rpn4p levels are in turn regulated bythe 26S proteasome in a negative feedbackcontrol mechanism; RPN4 is transcriptionallyregulated by various stress responses 0.009560.06511&radic&radic S000004873TIF11YMR260CverifiedTranslation initiation factor eIF1A, essential protein thatforms a complex with Sui1p (eIF1) and the 40Sribosomal subunit and scans for the startcodon; C-terminus associates with Fun12p(eIF5B); N terminus interacts with eIF2 andeIF3 0.009540.06507&radic&radic&radic&radic S000002217RAD59YDL059CverifiedProtein involved in the repair of double-strand breaks in DNAduring vegetative growth via recombination andsingle-strand annealing; anneals complementarysingle-stranded DNA; homologous to Rad52p 0.009530.06507&radic&radic&radic S000006081CDC60YPL160WverifiedCytosolic leucyl tRNA synthetase, ligates leucine to theappropriate tRNA 0.009530.06507&radic&radic&radic S000005361PHO80YOL001WverifiedCyclin, negatively regulates phosphate metabolism;Pho80p-Pho85p (cyclin-CDK complex)phosphorylates Pho4p and Swi5p; deletion ofPHO80 leads to aminoglycoside supersensitivity;truncated form of PHO80 affects vacuoleinheritance 0.009520.06497&radic&radic&radic&radic&radic S000001807BAS1YKR099WverifiedMyb-related transcription factor involved in regulating basaland induced expression of genes of the purineand histidine biosynthesis pathways 0.009510.06497&radic S000006181YPL260WUncharacterizedHypothetical protein 0.009490.06488&radic&radic&radic&radic S000003704SET2YJL168CverifiedHistone methyltransferase with a role in transcriptionalelongation, methylates a lysine residue ofhistone H3; associates with the C-terminaldomain of Rpo21p; histone methylation activityis regulated by phosphorylation status ofRpo21p 0.009490.06481&radic&radic&radic S000004015SNF7YLR025WverifiedOne of four subunits of the endosomal sorting complex requiredfor transport III (ESCRT-III); involved in thesorting of transmembrane proteins into themultivesicular body (MVB) pathway; recruitedfrom the cytoplasm to endosomal membranes 0.009490.06481&radic&radic S000000151YBL055CUncharacterizedHypothetical protein 0.009480.06465&radic&radic&radic&radic S000002559GIR2YDR152WverifiedHighly-acidic cytoplasmic RWD domain-containing protein ofunknown function, sensitive to proteolysis,N-terminal region has high content of acidicamino acid residues, putative IUP(intrinsically unstructured protein) 0.009480.06465&radic&radic&radic&radic S000004422SEN1YLR430WverifiedPutative helicase required for RNA polymerase II transcriptiontermination and processing of RNAs; homolog ofSenataxin which causes Ataxia-OculomotorApraxia 2 and a dominant form of amyotrophiclateral sclerosis 0.009440.06445&radic S000005530UTP23YOR004WverifiedEssential nucleolar protein that is a component of the SSU(small subunit) processome involved in 40Sribosomal subunit biogenesis; has homology toPINc domain protein Fcf1p, although the PINcdomain of Utp23p is not required for function 0.009440.06445&radic&radic&radic&radic S000004378VAC14YLR386WverifiedProtein involved in regulated synthesis of PtdIns(3,5)P(2), incontrol of trafficking of some proteins to thevacuole lumen via the MVB, and in maintenanceof vacuole size and acidity; activator of Fab1p 0.009430.06445&radic S000002334AIR2YDL175CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p; may regulatemethylation of Npl3p, which modulates Npl3pfunction in mRNA processing and export; hassimilarity to Air1p 0.009450.06445&radic&radic S000004246HAP1YLR256WverifiedZinc finger transcription factor involved in the complexregulation of gene expression in response tolevels of heme and oxygen; the S288C sequencediffers from other strain backgrounds due to aTy1 insertion in the carboxy terminus 0.009450.06445&radic S000004712YKU80YMR106CverifiedSubunit of the telomeric Ku complex (Yku70p-Yku80p), involvedin telomere length maintenance, structure andtelomere position effect; relocates to sites ofdouble-strand cleavage to promote nonhomologousend joining during DSB repair 0.009410.06433&radic S000002773ESF1YDR365CverifiedNucleolar protein involved in pre-rRNA processing; depletioncauses severely decreased 18S rRNA levels 0.009420.06433&radic&radic&radic&radic S000000233CDS1YBR029CverifiedPhosphatidate cytidylyltransferase (CDP-diglyceridesynthetase); an enzyme that catalyzes thatconversion of CTP + phosphate into diphosphate+ CDP-diaclglyerol, a critical step in thesynthesis of all major yeast phospholipids 0.009430.06433 S000006073RRD2YPL152WverifiedActivator of the phosphotyrosyl phosphatase activity of PP2A;regulates G1 phase progression, theosmoresponse and microtubule dynamics;implicated in the spindle assembly check;subunit of the Tap42p-Pph21p-Rrd2p complex 0.00940.06424&radic&radic&radic&radic S000001333PCI8YIL071CverifiedPossible shared subunit of Cop9 signalosome (CSN) and eIF3,binds eIF3b subunit Prt1p, has possible dualfunctions in transcriptional and translationalcontrol, contains a PCI (Proteasome-COP9signalosome (CSN)-eIF3) domain 0.00940.06424&radic&radic S000005577YOR051CUncharacterizedNuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts 0.009390.06411&radic&radic&radic&radic&radic S000000953UBP3YER151CverifiedUbiquitin-specific protease that interacts with Bre5p toco-regulate anterograde and retrogradetransport between endoplasmic reticulum andGolgi compartments; inhibitor of genesilencing; cleaves ubiquitin fusions but notpolyubiquitin 0.009370.06402&radic S000002308ATG9YDL149WverifiedTransmembrane protein involved in formation of Cvt andautophagic vesicles; cycles between thepre-autophagosomal structure and othercytosolic punctate structures, not found inautophagosomes 0.009360.064 S000001213NMD3YHR170WverifiedProtein involved in nuclear export of the large ribosomalsubunit; acts as a Crm1p-dependent adapterprotein for export of nascent ribosomalsubunits through the nuclear pore complex 0.009350.06389&radic S000004804GYL1YMR192WverifiedPutative GTPase activating protein (GAP) that may have a rolein polarized exocytosis; stimulates Gyp5p GAPactivity on Ypt1p, colocalizes with Gyp5p atsites of polarized growth; interacts withGyp5p, Rvs161p, and Rvs167p 0.009330.06373&radic&radic&radic S000003391NSR1YGR159CverifiedNucleolar protein that binds nuclear localization sequences,required for pre-rRNA processing and ribosomebiogenesis 0.009330.06373&radic&radic&radic&radic&radic S000001226GND1YHR183Wverified6-phosphogluconate dehydrogenase (decarboxylating), catalyzesan NADPH regenerating reaction in the pentosephosphate pathway; required for growth onD-glucono-delta-lactone and adaptation tooxidative stress 0.009320.06373&radic&radic&radic&radic S000001578YJU2YKL095WverifiedEssential nuclear protein; putative spliceosomal componentinvolved in mRNA splicing, based oncomputational analysis of large-scaleprotein-protein interaction data 0.009310.06362&radic&radic&radic&radic S000007271BI2Q0110verifiedMitochondrial mRNA maturase with a role in splicing, encoded byboth exon and intron sequences of partiallyprocessed COB mRNA 0.009310.06362 S000002646SEC26YDR238CverifiedEssential beta-coat protein of the COPI coatomer, involved inER-to-Golgi protein trafficking and maintenanceof normal ER morphology; shares 43% sequenceidentity with mammalian beta-coat protein(beta-COP) 0.009310.06362&radic&radic S000005125YNL181WUncharacterizedProtein required for cell viability 0.009290.06346&radic&radic&radic&radic&radic S000000400PGI1YBR196CverifiedGlycolytic enzyme phosphoglucose isomerase, catalyzes theinterconversion of glucose-6-phosphate andfructose-6-phosphate; required for cell cycleprogression and completion of the gluconeogenicevents of sporulation 0.009290.06346&radic&radic&radic S000001411MLP2YIL149CverifiedMyosin-like protein associated with the nuclear envelope,connects the nuclear pore complex with thenuclear interior; involved in the Tel1p pathwaythat controls telomere length 0.009290.06346&radic S000004843RPS10BYMR230WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps10Ap and has similarity to ratribosomal protein S10 0.00930.06346&radic&radic S000007260COX1Q0045verifiedSubunit I of cytochrome c oxidase, which is the terminal memberof the mitochondrial inner membrane electrontransport chain; one of threemitochondrially-encoded subunits 0.009250.06317 S000000150YBL054WUncharacterizedHypothetical protein 0.009270.06317&radic&radic&radic&radic S000003638MEF2YJL102WverifiedMitochondrial elongation factor involved in translationalelongation 0.009250.06317 S000001800SRP40YKR092CverifiedNucleolar, serine-rich protein with a role in preribosomeassembly or transport; may function as achaperone of small nucleolar ribonucleoproteinparticles (snoRNPs); immunologically andstructurally to rat Nopp140 0.009280.06317&radic&radic S000003739PRP21YJL203WverifiedSubunit of the SF3a splicing factor complex, required forspliceosome assembly 0.009250.06317&radic&radic&radic&radic&radic S000006214RPA135YPR010CverifiedRNA polymerase I subunit A135 0.009240.06311&radic S000001112TRM5YHR070WverifiedtRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacentto the anticodon that has a role in preventionof frameshifting; highly conserved acrossArchaea, Bacteria, and Eukarya 0.009240.06311&radic&radic&radic S000004116YLR126CUncharacterizedPutative protein of unknown function with similarity to glutamine amidotransferase proteins; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein 0.009220.063&radic&radic&radic&radic S000000752SNU13YEL026WverifiedRNA binding protein, part of U3 snoRNP involved in rRNAprocessing, part of U4/U6-U5 tri-snRNP involvedin mRNA splicing, similar to human 15.5Kprotein 0.009210.06289&radic&radic&radic&radic S000002660BTT1YDR252WverifiedBeta3 subunit of the heterotrimeric nascentpolypeptide-associated complex (alpha, beta1,beta3) which binds ribosomes via itsbeta-subunits in close proximity to nascentpolypeptides 0.009190.06281&radic&radic&radic&radic S000002557NUM1YDR150WverifiedProt