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Prediction of GO:0007062 "sister chromatid cohesion"

GO branch: BP
Number of currently annotated genes: 29

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest Huh:nucleusHarbison:MBP1_H2O2HiIPR003593Parsons:HydroxyureaTAP:125IPR008921TAP:130Parsons:CamptothecinPF03828Lee:MBP1 S000005234RFC3YNL290WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon &radic0.463490.96153&radic&radic&radic&radic S000005454RFC4YOL094CverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon &radic0.432370.95967&radic&radic&radic&radic S000003829RFC2YJR068WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon &radic0.427050.95967&radic&radic&radic&radic S000002161MCD1YDL003WverifiedEssential protein required for sister chromatid cohesion inmitosis and meiosis; subunit of the cohesincomplex; expression is cell cycle regulated andpeaks in S phase &radic0.412670.94871&radic&radic&radic S000001886SMC1YFL008WverifiedSubunit of the multiprotein cohesin complex, essential proteininvolved in chromosome segregation and indouble-strand DNA break repair; SMC chromosomalATPase family member, binds DNA with apreference for DNA with secondary structure &radic0.312580.85556&radic&radic&radic S000003610SMC3YJL074CverifiedSubunit of the multiprotein cohesin complex required for sisterchromatid cohesion in mitotic cells; alsorequired, with Rec8p, for cohesion andrecombination during meiosis; phylogeneticallyconserved SMC chromosomal ATPase family member &radic0.305880.84792&radic&radic&radic&radic S000005743RFC1YOR217WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon 0.262590.8079&radic&radic&radic S000000291RFC5YBR087WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon &radic0.245220.80088&radic&radic&radic&radic S000001288IRR1YIL026CverifiedSubunit of the cohesin complex, which is required for sisterchromatid cohesion during mitosis and meiosisand interacts with centromeres and chromosomearms, essential for viability &radic0.250520.80088&radic&radic&radic&radic S000005206POL2YNL262WverifiedCatalytic subunit of DNA polymerase epsilon, one of the majorchromosomal DNA replication polymerasescharacterized by processivity and proofreadingexonuclease activity; also involved in DNAsynthesis during DNA repair 0.225350.78522&radic&radic S000005475PAP2YOL115WverifiedCatalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), anuclear poly (A) polymerase complex involved inRNA quality control; catalyzes polyadenylationof unmodified tRNAs, and snoRNA and rRNAprecursors; disputed role as a DNA polymerase &radic0.218150.77448&radic&radic S000004683CTF18YMR078CverifiedSubunit of a complex with Ctf8p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion; may have overlappingfunctions with Rad24p in the DNA damagereplication checkpoint &radic0.195990.75311&radic&radic&radic&radic S000005243TRF5YNL299WverifiedPoly (A) polymerase involved in nuclear RNA quality controlbased on: homology with Trf4p, geneticinteractions with TRF4 mutants, physicalinteraction with Mtr4p (TRAMP subunit), and bydirect assay; disputed role as a sigma DNApolymerase &radic0.185650.74793&radic S000001234CTF8YHR191CverifiedSubunit of a complex with Ctf18p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion &radic0.162820.71662&radic&radic&radic S000006211REC8YPR007CverifiedMeiosis-specific component of sister chromatid cohesioncomplex; maintains cohesion between sisterchromatids during meiosis I; maintains cohesionbetween centromeres of sister chromatids untilmeiosis II; homolog of S. pombe Rec8p &radic0.15730.70833 S000000975RAD24YER173WverifiedCheckpoint protein, involved in the activation of the DNAdamage and meiotic pachytene checkpoints;subunit of a clamp loader that loadsRad17p-Mec3p-Ddc1p onto DNA; homolog of humanand S. pombe Rad17 protein 0.148440.69868&radic&radic&radic S000004811CIK1YMR198WverifiedKinesin-associated protein required for both karyogamy andmitotic spindle organization, interacts stablyand specifically with Kar3p and may function totarget this kinesin to a specific cellularrole; has similarity to Vik1p 0.144010.68897&radic S000004494RAD52YML032CverifiedProtein that stimulates strand exchange by facilitating Rad51pbinding to single-stranded DNA; annealscomplementary single-stranded DNA; involved inthe repair of double-strand breaks in DNAduring vegetative growth and meiosis 0.135460.6794&radic&radic&radic S000003651ASF1YJL115WverifiedNucleosome assembly factor, involved in chromatin assembly anddisassembly, anti-silencing protein that causesderepression of silent loci when overexpressed 0.119210.65325&radic&radic&radic S000003420BUB1YGR188CverifiedProtein kinase that forms a complex with Mad1p and Bub3p thatis crucial in the checkpoint mechanism requiredto prevent cell cycle progression into anaphasein the presence of spindle damage, associateswith centromere DNA via Skp1p 0.117160.65102&radic&radic&radic S000006379DPB2YPR175WverifiedSecond largest subunit of DNA polymerase II (DNA polymeraseepsilon), required for normal yeast chromosomalreplication; expression peaks at the G1/S phaseboundary; potential Cdc28p substrate 0.109820.63501&radic&radic&radic S000004837MRE11YMR224CverifiedSubunit of a complex with Rad50p and Xrs2p (RMX complex) thatfunctions in repair of DNA double-strand breaksand in telomere stability, exhibits nucleaseactivity that appears to be required for RMXfunction; widely conserved 0.101810.61879&radic&radic&radic S000002625RAD9YDR217CverifiedDNA damage-dependent checkpoint protein, required forcell-cycle arrest in G1/S, intra-S, and G2/M;transmits checkpoint signal by activatingRad53p and Chk1p; hyperphosphorylated by Mec1pand Tel1p; potential Cdc28p substrate 0.098450.6158&radic&radic S000000787CIN8YEL061CverifiedKinesin motor protein involved in mitotic spindle assembly andchromosome segregation 0.094860.60694 S000005194RAD50YNL250WverifiedSubunit of MRX complex, with Mre11p and Xrs2p, involved inprocessing double-strand DNA breaks invegetative cells, initiation of meiotic DSBs,telomere maintenance, and nonhomologous endjoining 0.087410.5943&radic&radic&radic S000000566MRC1YCL061CverifiedS-phase checkpoint protein found at replication forks, requiredfor DNA replication; also required for Rad53pactivation during DNA replication stress, whereit forms a replication-pausing complex withTof1p and is phosphorylated by Mec1p; proteininvolved in replication checkpoint 0.086110.59185&radic&radic S000000521DCC1YCL016CverifiedSubunit of a complex with Ctf8p and Ctf18p that shares somecomponents with Replication Factor C, requiredfor sister chromatid cohesion and telomerelength maintenance &radic0.081840.58343&radic&radic&radic S000004802SGS1YMR190CverifiedNucleolar DNA helicase of the RecQ family involved inmaintenance of genome integrity, regulateschromosome synapsis and meiotic crossing over;has similarity to human BLM and WRN helicasesimplicated in Bloom and Werner syndromes 0.079590.57994&radic&radic&radic S000001927SMC2YFR031CverifiedComponent of the condensin complex, essential SMC chromosomalATPase family member that forms a complex withSmc4p to form the active ATPase; Smc2p/Smc4pcomplex binds DNA, possibly in the cleft formedby the coiled-coil of the folded dimer 0.075190.57007&radic S000005032TOP2YNL088WverifiedEssential type II topoisomerase, relieves torsional strain inDNA by cleaving and re-sealing thephosphodiester backbone of both positively andnegatively supercoiled DNA; cleavescomplementary strands; localizes to axial coresin meiosis 0.074170.56837&radic&radic S000000897RAD51YER095WverifiedStrand exchange protein, forms a helical filament with DNA thatsearches for homology; involved in therecombinational repair of double-strand breaksin DNA during vegetative growth and meiosis;homolog of Dmc1p and bacterial RecA protein 0.070120.56053&radic&radic&radic&radic&radic&radic S000003372CBF2YGR140WverifiedEssential kinetochore protein, component of the CBF3multisubunit complex that binds to the CDEIIIregion of the centromere; Cbf2p also binds tothe CDEII region possibly forming a differentmultimeric complex, ubiquitinated in vivo 0.06880.55639&radic S000003628HPR5YJL092WverifiedDNA helicase and DNA-dependent ATPase involved in DNA repair,required for proper timing of commitment tomeiotic recombination and the transition fromMeiosis I to Meiosis II; potential Cdc28psubstrate 0.06410.54214&radic&radic&radic S000004975HHF2YNL030WverifiedOne of two identical histone H4 proteins (see also HHF1); corehistone required for chromatin assembly andchromosome function; contributes to telomericsilencing; N-terminal domain involved inmaintaining genomic integrity 0.064050.54137&radic&radic&radic S000000302MMS4YBR098WverifiedSubunit of the structure-specific Mms4p-Mus81p endonucleasethat cleaves branched DNA; involved inrecombination and DNA repair 0.063210.5395&radic&radic&radic S000003288RSC1YGR056WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; containstwo essential bromodomains, a bromo-adjacenthomology (BAH) domain, and an AT hook 0.062940.53861 S000003131RAD54YGL163CverifiedDNA-dependent ATPase, stimulates strand exchange by modifyingthe topology of double-stranded DNA; involvedin the recombinational repair of double-strandbreaks in DNA during vegetative growth andmeiosis; member of the SWI/SNF family 0.062690.53668&radic&radic&radic S000006115DDC1YPL194WverifiedDNA damage checkpoint protein, part of a PCNA-like complexrequired for DNA damage response, required forpachytene checkpoint to inhibit cell cycle inresponse to unrepaired recombinationintermediates; potential Cdc28p substrate 0.062710.53668&radic&radic&radic S000003865SOD1YJR104CverifiedCytosolic superoxide dismutase; some mutations are analogous tothose that cause ALS (amyotrophic lateralsclerosis) in humans 0.061770.53529&radic&radic&radic S000002411RAD57YDR004WverifiedProtein that stimulates strand exchange by stabilizing thebinding of Rad51p to single-stranded DNA;involved in the recombinational repair ofdouble-strand breaks in DNA during vegetativegrowth and meiosis; forms heterodimer withRad55p 0.061730.53375&radic&radic&radic&radic S000004641CCS1YMR038CverifiedCopper chaperone for superoxide dismutase Sod1p, involved inoxidative stress protection; Met-X-Cys-X2-Cysmotif within the N-terminal portion is involvedin insertion of copper into Sod1p underconditions of copper deprivation 0.061040.53272&radic&radic S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling 0.06040.53179&radic&radic&radic S000005217TOF1YNL273WverifiedSubunit of a replication-pausing checkpoint complex(Tof1p-Mrc1p-Csm3p) that acts at the stalledreplication fork to promote sister chromatidcohesion after DNA damage, facilitating gaprepair of damaged DNA; interacts with the MCMhelicase &radic0.060240.53116&radic&radic&radic&radic S000001388STH1YIL126WverifiedATPase component of the ATP-dependent RSC chromatin remodelingcomplex required for kinetochore function inchromosome segregation; required for expressionof early meiotic genes; essentialhelicase-related protein homologous to Snf2p 0.059380.52664&radic S000004651CSM3YMR048WverifiedProtein required for accurate chromosome segregation duringmeiosis &radic0.05730.51955&radic&radic S000006345KAR3YPR141CverifiedMinus-end-directed microtubule motor that functions in mitosisand meiosis, localizes to the spindle pole bodyand localization is dependent on functionalCik1p, required for nuclear fusion duringmating; potential Cdc28p substrate &radic0.055960.51541&radic&radic S000000912KAP123YER110CverifiedKaryopherin beta, mediates nuclear import of ribosomal proteinsprior to assembly into ribosomes and import ofhistones H3 and H4; localizes to the nuclearpore, nucleus, and cytoplasm; exhibits geneticinteractions with RAI1 0.055160.51274&radic&radic S000005929CHL1YPL008WverifiedConserved nuclear protein required to establishsister-chromatid pairing during S-phase,probable DNA helicase with similarity to humanBACH1, which associates with tumor suppressorBRCA1; associates with acetyltransferase Ctf7p &radic0.053670.50778&radic&radic S000006003MOT1YPL082CverifiedEssential abundant protein involved in regulation oftranscription, removes Spt15p (TBP) from DNAvia its C-terminal ATPase activity, forms acomplex with TBP that binds TATA DNA with highaffinity but with altered specificity 0.051330.49572&radic&radic S000004391BDF1YLR399CverifiedProtein involved in transcription initiation at TATA-containingpromoters; associates with the basaltranscription factor TFIID; contains twobromodomains; corresponds to the C-terminalregion of mammalian TAF1; redundant with Bdf2p 0.050910.49169&radic&radic&radic S000004224TOP3YLR234WverifiedDNA Topoisomerase III, conserved protein that functions in acomplex with Sgs1p and Rmi1p to relaxsingle-stranded negatively-supercoiled DNApreferentially, involved in telomere stabilityand regulation of mitotic recombination 0.049130.48581&radic&radic&radic S000003804POL32YJR043CverifiedThird subunit of DNA polymerase delta, involved in chromosomalDNA replication; required for error-prone DNAsynthesis in the presence of DNA damage andprocessivity; interacts with Hys2p, PCNA(Pol30p), and Pol1p 0.047630.48101&radic&radic&radic S000002483RAD55YDR076WverifiedProtein that stimulates strand exchange by stabilizing thebinding of Rad51p to single-stranded DNA;involved in the recombinational repair ofdouble-strand breaks in DNA during vegetativegrowth and meiosis; forms heterodimer withRad57p 0.046960.4782&radic&radic&radic S000000949SCC4YER147CverifiedSubunit of cohesin loading factor (Scc2p-Scc4p), a complexrequired for the loading of cohesin complexesonto chromosomes; involved in establishingsister chromatid cohesion during double-strandbreak repair via phosphorylated histone H2AX &radic0.04680.47717&radic&radic S000004076SMC4YLR086WverifiedSubunit of the condensin complex, which reorganizes chromosomesduring cell division, forms a stable complexwith Smc2p that has ATP-hydrolyzing andDNA-binding activity and promotes knotting ofcircular DNA; potential Cdc28p substrate 0.046730.47717&radic S000003545CCT8YJL008CverifiedSubunit of the cytosolic chaperonin Cct ring complex, relatedto Tcp1p, required for the assembly of actinand tubulins in vivo 0.04650.4753&radic S000005401NOP12YOL041CverifiedNucleolar protein, required for pre-25S rRNA processing;contains an RNA recognition motif (RRM) and hassimilarity to Nop13p, Nsr1p, and putativeorthologs in Drosophila and S. pombe 0.046350.47431&radic S000003466YHB1YGR234WverifiedNitric oxide oxidoreductase, flavohemoglobin involved in nitricoxide detoxification; plays a role in theoxidative and nitrosative stress responses 0.045820.47296&radic S000006076KIP2YPL155CverifiedKinesin-related motor protein involved in mitotic spindlepositioning, stabilizes microtubules bytargeting Bik1p to the plus end; Kip2p levelsare controlled during the cell cycle 0.045730.47269 S000006156RVB2YPL235WverifiedEssential protein involved in transcription regulation;component of chromatin remodeling complexes;required for assembly and function of the INO80complex; member of the RUVB-like protein family 0.044420.46449&radic&radic S000005670ELG1YOR144CverifiedProtein required for S phase progression and telomerehomeostasis, forms an alternative replicationfactor C complex important for DNA replicationand genome integrity; involved in homologousrecombination-mediated DNA repair 0.043660.46013&radic S000000154SHP1YBL058WverifiedUBX (ubiquitin regulatory X) domain-containing protein thatregulates Glc7p phosphatase activity andinteracts with Cdc48p; interacts withubiquitylated proteins in vivo and is requiredfor degradation of a ubiquitylated modelsubstrate 0.043380.45932&radic&radic&radic S000004550TUB1YML085CverifiedAlpha-tubulin; associates with beta-tubulin (Tub2p) to formtubulin dimer, which polymerizes to formmicrotubules 0.042730.45675 S000002733YCG1YDR325WverifiedNon-SMC subunit of the condensin complex(Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required forestablishment and maintenance of chromosomecondensation, chromosome segregation and forchromatin binding of the condensin complex 0.041120.44934&radic S000004793YMR181CUncharacterizedProtein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene 0.040470.4457&radic S000003963VPS13YLL040CverifiedProtein of unknown function; heterooligomeric or homooligomericcomplex; peripherally associated withmembranes; homologous to human COH1; involvedin sporulation, vacuolar protein sorting andprotein-Golgi retention 0.039880.44236&radic S000004093CDC45YLR103CverifiedDNA replication initiation factor; recruited to MCM pre-RCcomplexes at replication origins; promotesrelease of MCM from Mcm10p, recruits elongationmachinery; mutants in human homolog may causevelocardiofacial and DiGeorge syndromes 0.039620.44135&radic&radic S000000918SLX8YER116CverifiedProtein containing a RING finger domain that interacts withHex3p; mutant phenotypes and geneticinteractions suggest a role in sumoylation andin genome stability 0.039140.43944&radic&radic S000003095SOH1YGL127CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; involved in telomeremaintenance; conserved with other metazoanMED31 subunits 0.03860.43674&radic&radic S000003184KIP3YGL216WverifiedKinesin-related motor protein involved in mitotic spindlepositioning 0.03810.43325 S000000404BEM1YBR200WverifiedProtein containing SH3-domains, involved in establishing cellpolarity and morphogenesis; functions as ascaffold protein for complexes that includeCdc24p, Ste5p, Ste20p, and Rsr1p 0.03820.43325&radic&radic S000002767VID21YDR359CverifiedComponent of the NuA4 histone acetyltransferase complex 0.037940.43187&radic&radic S000005599SGO1YOR073WverifiedComponent of the spindle checkpoint, involved in sensing lackof tension on mitotic chromosomes; protectscentromeric Rec8p at meiosis I; required foraccurate chromosomal segregation at meiosis IIand for mitotic chromosome stability 0.037920.43187&radic&radic S000001197RTT107YHR154WverifiedProtein implicated in Mms22-dependent DNA repair during Sphase, DNA damage induces phosphorylation byMec1p at one or more SQ/TQ motifs; interactswith Mms22p and Slx4p; has four BRCT domains;has a role in regulation of Ty1 transposition 0.037870.4313&radic&radic&radic&radic&radic S000004925PSE1YMR308CverifiedKaryopherin/importin that interacts with the nuclear porecomplex; acts as the nuclear import receptorfor specific proteins, including Pdr1p, Yap1p,Ste12p, and Aft1p 0.037860.4313&radic S000000885GET2YER083CverifiedSubunit of the GET complex; required for meiotic nucleardivision and for the retrieval of HDEL proteinsfrom the Golgi to the ER in an ERD2 dependentfashion; may be involved in cell wall function 0.037560.43014&radic&radic S000001923ECO1YFR027WverifiedAcetyltransferase required for the establishment of sisterchromatid cohesion during DNA replication, butnot for its maintenance during G2 and M phases;also required for postreplicative double-strandbreak repair; interacts with Chl1p &radic0.037050.42723&radic S000003163GCN1YGL195WverifiedPositive regulator of the Gcn2p kinase activity, forms acomplex with Gcn20p; proposed to stimulateGcn2p activation by an uncharged tRNA 0.036960.42549&radic S000005046POL1YNL102WverifiedCatalytic subunit of the DNA polymerase alpha-primase complex,required for the initiation of DNA replicationduring mitotic DNA synthesis and premeiotic DNAsynthesis 0.036750.42523&radic&radic S000002259DUN1YDL101CverifiedCell-cycle checkpoint serine-threonine kinase required for DNAdamage-induced transcription of certain targetgenes, phosphorylation of Rad55p and Sml1p, andtransient G2/M arrest after DNA damage; alsoregulates postreplicative DNA repair 0.036540.42344&radic&radic&radic&radic S000000039CDC24YAL041WverifiedGuanine nucleotide exchange factor (GEF or GDP-release factor)for Cdc42p; required for polarity establishmentand maintenance, and mutants have morphologicaldefects in bud formation and shmooing 0.036080.42169&radic S000003213RTF1YGL244WverifiedSubunit of the RNA polymerase II-associated Paf1 complex;directly or indirectly regulates DNA-bindingproperties of Spt15p and relative activities ofdifferent TATA elements; involved in telomeremaintenance 0.035660.41871&radic&radic S000003586MTR4YJL050WverifiedDead-box family ATP dependent helicase required for mRNA exportfrom the nucleus; co-factor of the exosomecomplex, required for 3' end formation of 5.8SrRNA 0.03520.41657&radic S000003925RTT109YLL002WverifiedProtein with a role in regulation of Ty1 transposition 0.035150.41567&radic&radic&radic S000005876CIN1YOR349WverifiedTubulin folding factor D involved in beta-tubulin (Tub2p)folding; isolated as mutant with increasedchromosome loss and sensitivity to benomyl 0.03420.41073 S000002588SCC2YDR180WverifiedSubunit of cohesin loading factor (Scc2p-Scc4p), a complexrequired for the loading of cohesin complexesonto chromosomes; involved in establishingsister chromatid cohesion during DSB repair viahistone H2AX &radic0.034060.41072&radic S000004378VAC14YLR386WverifiedProtein involved in regulated synthesis of PtdIns(3,5)P(2), incontrol of trafficking of some proteins to thevacuole lumen via the MVB, and in maintenanceof vacuole size and acidity; activator of Fab1p 0.03310.40447&radic S000001716RSC4YKR008WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; found in close proximity tonucleosomal DNA; displaced from the surface ofnucleosomal DNA after chromatin remodeling 0.032920.40436&radic S000006339CTF4YPR135WverifiedChromatin-associated protein, required for sister chromatidcohesion; interacts with DNA polymerase alpha(Pol1p) and may link DNA synthesis to sisterchromatid cohesion &radic0.032790.40355&radic&radic&radic S000000159KIP1YBL063WverifiedKinesin-related motor protein required for mitotic spindleassembly and chromosome segregation;functionally redundant with Cin8p 0.032270.40071 S000003730CDC6YJL194WverifiedEssential ATP-binding protein required for DNA replication,component of the pre-replicative complex(pre-RC) which requires ORC to associate withchromatin and is in turn required for Mcm2-7pDNA association; homologous to S. pombe Cdc18p 0.032290.40071&radic&radic&radic&radic S000004022RAD5YLR032WverifiedSingle-stranded DNA-dependent ATPase, involved inpostreplication repair; contains RING fingerdomain 0.031620.39714&radic&radic S000005895RAD17YOR368WverifiedCheckpoint protein, involved in the activation of the DNAdamage and meiotic pachytene checkpoints; withMec3p and Ddc1p, forms a clamp that is loadedonto partial duplex DNA; homolog of human andS. pombe Rad1 and U. maydis Rec1 proteins 0.030930.39278&radic&radic S000004035STU2YLR045CverifiedMicrotubule-associated protein (MAP) of the XMAP215/Dis1family; regulates microtubule dynamics duringspindle orientation and metaphase chromosomealignment; interacts with spindle pole bodycomponent Spc72p 0.030870.39251 S000004312MMS22YLR320WverifiedProtein involved in resistance to ionizing radiation; acts withMms1p in a repair pathway that may be involvedin resolving replication intermediates orpreventing the damage caused by blockedreplication forks 0.030440.3893&radic&radic S000004279MEC3YLR288CverifiedDNA damage and meiotic pachytene checkpoint protein; subunit ofa heterotrimeric complex (Rad17p-Mec3p-Ddc1p)that forms a sliding clamp, loaded onto partialduplex DNA by a clamp loader complex; homologof human and S. pombe Hus1 0.029860.38683&radic&radic S000000019CCR4YAL021CverifiedComponent of the CCR4-NOT transcriptional complex, which isinvolved in regulation of gene expression;component of the major cytoplasmic deadenylase,which is involved in mRNA poly(A) tailshortening 0.02980.38667&radic&radic S000000534BIK1YCL029CverifiedMicrotubule-associated protein, component of the interfacebetween microtubules and kinetochore, involvedin sister chromatid separation; essential inpolyploid cells but not in haploid or diploidcells; ortholog of mammalian CLIP-170 0.029820.38667 S000000821ISC1YER019WverifiedInositol phosphosphingolipid phospholipase C, hydrolyzesinositolphosphosphingolipids, activated byphosphatidylserine, cardiolipin, andphosphatidylglycerol, mediates Na+ and Li+halotolerance, contains a P loop-like domain 0.029610.38557&radic S000005366TOP1YOL006CverifiedTopoisomerase I, nuclear enzyme that relieves torsional strainin DNA by cleaving and re-sealing thephosphodiester backbone; relaxes bothpositively and negatively supercoiled DNA;functions in replication, transcription, andrecombination 0.028920.38197&radic S000002536SAC6YDR129CverifiedFimbrin, actin-bundling protein; cooperates with Scp1p(calponin/transgelin) in the organization andmaintenance of the actin cytoskeleton 0.028830.38094 S000000292POL30YBR088CverifiedProliferating cell nuclear antigen (PCNA), functions as thesliding clamp for DNA polymerase delta; mayfunction as a docking site for other proteinsrequired for mitotic and meiotic chromosomalDNA replication and for DNA repair 0.028380.37723&radic S000002217RAD59YDL059CverifiedProtein involved in the repair of double-strand breaks in DNAduring vegetative growth via recombination andsingle-strand annealing; anneals complementarysingle-stranded DNA; homologous to Rad52p 0.028190.37631&radic&radic&radic S000003084CDC20YGL116WverifiedCell-cycle regulated activator of anaphase-promotingcomplex/cyclosome (APC/C), which is requiredfor metaphase/anaphase transition; directsubiquitination of mitotic cyclins, Pds1p, andother anaphase inhibitors; potential Cdc28psubstrate 0.027320.3708&radic S000005436MDM20YOL076WverifiedNon-catalytic subunit of the NatB N-terminal acetyltransferase,which catalyzes acetylation of theamino-terminal methionine residues of allproteins beginning with Met-Asp or Met-Glu andof some proteins beginning with Met-Asn orMet-Met; involved in mitochondrial inheritanceand actin assembly 0.027260.36999&radic&radic S000000014TPD3YAL016WverifiedRegulatory subunit A of the heterotrimeric protein phosphatase2A, which also contains regulatory subunitCdc55p and either catalytic subunit Pph21p orPph22p; required for cell morphogenesis and fortranscription by RNA polymerase III 0.026540.36394&radic S000002274NUP84YDL116WverifiedSubunit of the nuclear pore complex (NPC), forms a subcomplexwith Nup85p, Nup120p, Nup145p-C, Sec13p, andSeh1p that plays a role in nuclear mRNA exportand NPC biogenesis 0.026370.36259&radic&radic S000002591PLP1YDR183WverifiedProtein with a possible role in folding of beta-tubulin; hassimilarity to phosducins, which are GTPaseinhibitors 0.026290.36207 S000005335POP2YNR052CverifiedRNase of the DEDD superfamily, subunit of the Ccr4-Not complexthat mediates 3' to 5' mRNA deadenylation 0.026180.36156&radic&radic S000004791SPT21YMR179WverifiedProtein required for normal transcription at several lociincluding HTA2-HTB2 and HHF2-HHT2, but notrequired at the other histone loci;functionally related to Spt10p; involved intelomere maintenance 0.026060.36104&radic&radic&radic S000000973RAD3YER171Wverified5' to 3' DNA helicase, involved in nucleotide excision repairand transcription; subunit of RNA polymerase IItranscription initiation factor TFIIH; subunitof Nucleotide Excision Repair Factor 3 (NEF3);homolog of human XPD protein 0.025180.35559&radic S000001160ORC6YHR118CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing; may be phosphorylated by Cdc28p 0.025140.35527&radic S000003660LSM1YJL124CverifiedLsm (Like Sm) protein; forms heteroheptameric complex (withLsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p)involved in degradation of cytoplasmic mRNAs 0.024640.35141&radic&radic S000000189ROX3YBL093CverifiedRNA polymerase II holoenzyme component 0.02440.34994&radic&radic S000004017AAT2YLR027CverifiedCytosolic aspartate aminotransferase, involved in nitrogenmetabolism; localizes to peroxisomes inoleate-grown cells 0.024290.34913&radic S000001596RAD27YKL113Cverified5' to 3' exonuclease, 5' flap endonuclease, required forOkazaki fragment processing and maturation aswell as for long-patch base-excision repair;member of the S. pombe RAD2/FEN1 family 0.024180.34816&radic&radic&radic S000002615UME6YDR207CverifiedKey transcriptional regulator of early meiotic genes, bindsURS1 upstream regulatory sequence, couplesmetabolic responses to nutritional cues withinitiation and progression of meiosis, formscomplex with Ime1p, and also with Sin3p-Rpd3p 0.024110.34764&radic&radic S000002662CHL4YDR254WverifiedOuter kinetochore protein required for chromosome stability,interacts with kinetochore proteins Ctf19p,Ctf3p, and Iml3p; exhibits a two-hybridinteraction with Mif2p; association with CENDNA requires Ctf19p 0.023660.3439 S000002794MUS81YDR386WverifiedHelix-hairpin-helix protein, involved in DNA repair andreplication fork stability; functions as anendonuclease in complex with Mms4p; interactswith Rad54p 0.023630.3439&radic&radic S000003324DBF2YGR092WverifiedSer/Thr kinase involved in transcription and stress response;functions as part of a network of genes in exitfrom mitosis; localization is cell cycleregulated; activated by Cdc15p during the exitfrom mitosis 0.023570.34336&radic&radic S000001790NUP133YKR082WverifiedSubunit of the Nup84p subcomplex of the nuclear pore complex(NPC), localizes to both sides of the NPC,required to establish a normalnucleocytoplasmic concentration gradient of theGTPase Gsp1p 0.023360.34164&radic S000000673PAT1YCR077CverifiedTopoisomerase II-associated deadenylation-dependentmRNA-decapping factor; also required forfaithful chromosome transmission, maintenanceof rDNA locus stability, and protection of mRNA3'-UTRs from trimming; functionally linked toPab1p 0.022060.32899&radic&radic S000002334AIR2YDL175CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p; may regulatemethylation of Npl3p, which modulates Npl3pfunction in mRNA processing and export; hassimilarity to Air1p 0.02190.32841&radic S000000131POL12YBL035CverifiedB subunit of DNA polymerase alpha-primase complex, required forinitiation of DNA replication during mitoticand premeiotic DNA synthesis; also functions intelomere capping and length regulation 0.021880.328&radic&radic S000006190KAR9YPL269WverifiedKaryogamy protein required for correct positioning of themitotic spindle and for orienting cytoplasmicmicrotubules, localizes at the shmoo tip inmating cells and at the tip of the growing budin small-budded cells through anaphase 0.021860.328 S000002520PDS1YDR113CverifiedSecurin that inhibits anaphase by binding separin Esp1p, alsoblocks cyclin destruction and mitotic exit,essential for cell cycle arrest in mitosis inthe presence of DNA damage or aberrant mitoticspindles; also present in meiotic nuclei 0.021840.32777&radic S000001852YFL042CUncharacterizedPutative protein of unknown function; YFL042C is not an essential gene 0.021850.32777&radic S000000818BIM1YER016WverifiedMicrotubule-binding protein that together with Kar9p makes upthe cortical microtubule capture site anddelays the exit from mitosis when the spindleis oriented abnormally &radic0.021490.32412&radic S000005361PHO80YOL001WverifiedCyclin, negatively regulates phosphate metabolism;Pho80p-Pho85p (cyclin-CDK complex)phosphorylates Pho4p and Swi5p; deletion ofPHO80 leads to aminoglycoside supersensitivity;truncated form of PHO80 affects vacuoleinheritance 0.021290.32231&radic&radic S000000770IES6YEL044WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.021310.32231&radic&radic&radic S000005584ASE1YOR058CverifiedMember of a family of microtubule-associated proteins (MAPs)that function at the mitotic spindle midzone;required for spindle elongation; undergoes cellcycle-regulated degradation by anaphasepromoting complex; potential Cdc28p substrate 0.021080.32075 S000002711RSC3YDR303CverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; essential gene required forregulation of ribosomal protein genes and thecell wall/stress response; highly similar toRsc30p 0.020980.31997&radic S000001083SRB2YHR041CverifiedGeneral transcription factor, subunit of the RNA polymerase IImediator complex; associates with corepolymerase subunits to form the RNA polymeraseII holoenzyme; involved in telomere maintenance 0.020840.31846&radic&radic S000004596RSC9YML127WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; DNA-binding protein involved inthe synthesis of rRNA and in transcriptionalrepression and activation of genes regulated bythe Target of Rapamycin (TOR) pathway 0.020480.3142&radic S000003055MMS2YGL087CverifiedProtein involved in error-free postreplication DNA repair;forms a heteromeric complex with Ubc13p thathas a ubiquitin-conjugating activity;cooperates with chromatin-associated RINGfinger proteins, Rad18p and Rad5p 0.020340.3133&radic&radic S000002786LSM6YDR378CverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.020260.31189&radic&radic S000002292PPH21YDL134CverifiedCatalytic subunit of protein phosphatase 2A, functionallyredundant with Pph22p; methylated at Cterminus; forms alternate complexes withseveral regulatory subunits; involved in signaltransduction and regulation of mitosis 0.020170.31117&radic S000002175CDC7YDL017WverifiedDDK (Dbf4-dependent kinase) catalytic subunit required forfiring origins and replication fork progressionin mitosis through phosphorylation of Mcm2-7pcomplexes and Cdc45p; kinase activitycorrelates with cyclical DBF4 expression 0.020060.30903&radic&radic&radic S000001933RSC8YFR037CverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; essential for viability andmitotic growth; homolog of SWI/SNF subunitSwi3p, but unlike Swi3p, does not activatetranscription of reporters 0.019820.30754&radic S000000950SPT15YER148WverifiedTATA-binding protein, general transcription factor thatinteracts with other factors to form thepreinitiation complex at promoters, essentialfor viability 0.01970.30628&radic S000000301VPS15YBR097WverifiedMyristoylated serine/threonine protein kinase involved invacuolar protein sorting; functions as amembrane-associated complex with Vps34p; activeform recruits Vps34p to the Golgi membrane;interacts with the GDP-bound form of Gpa1p 0.019660.3056 S000002566SAC3YDR159WverifiedNuclear pore-associated protein, forms a complex with Thp1pthat is involved in transcription and in mRNAexport from the nucleus 0.019590.30532&radic&radic S000003143SAE2YGL175CverifiedProtein with a role in accurate meiotic and mitoticdouble-strand break repair; phosphorylated inresponse to DNA damage and required for normalresistance to DNA-damaging agents 0.019480.30402&radic&radic&radic S000006172YPL251WDubiousHypothetical protein; open reading frame overlaps 5' end of essential YAH1 gene required for iron-sulfur protein biogenesis 0.019460.30362 S000004593TUB3YML124CverifiedAlpha-tubulin; associates with beta-tubulin (Tub2p) to formtubulin dimer, which polymerizes to formmicrotubules; expressed at lower level thanTub1p 0.019030.29678&radic S000002915GIN4YDR507CverifiedProtein kinase involved in bud growth and assembly of theseptin ring, proposed to have kinase-dependentand kinase-independent activities; undergoesautophosphorylation; similar to Kcc4p and Hsl1p 0.018940.29576&radic&radic S000006238ARP7YPR034WverifiedActin-related protein involved in transcriptional regulation;subunit of the chromatin remodeling Snf/Swicomplex 0.018270.28831&radic S000002581HMO1YDR174WverifiedChromatin associated high mobility group (HMG) family memberinvolved in genome maintenance; rDNA-bindingcomponent of the Pol I transcription system;associates with a 5'-3' DNA helicase and Fpr1p,a prolyl isomerase 0.018210.28797 S000004778CEP3YMR168CverifiedEssential kinetochore protein, component of the CBF3 complexthat binds the CDEIII region of the centromere;contains an N-terminal Zn2Cys6 type zinc fingerdomain, a C-terminal acidic domain, and aputative coiled coil dimerization domain 0.018190.28741 S000005816SNF2YOR290CverifiedCatalytic subunit of the SWI/SNF chromatin remodeling complexinvolved in transcriptional regulation;contains DNA-stimulated ATPase activity;functions interdependently in transcriptionalactivation with Snf5p and Snf6p 0.018150.28733&radic&radic S000003367PRE9YGR135Wverified20S proteasome beta-type subunit; the only nonessential 20Ssubunit 0.018010.28573&radic&radic S000006074RAD53YPL153CverifiedProtein kinase, required for cell-cycle arrest in response toDNA damage; activated by transautophosphorylation when interacting withhyperphosphorylated Rad9p; also interacts withARS1 and plays a role in initiation of DNAreplication 0.017970.28548&radic&radic S000001341AIR1YIL079CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p to regulate methylationof Npl3p, which modulates Npl3p function inmRNA processing and export; has similarity toAir2p 0.017740.28214&radic S000005372HTZ1YOL012CverifiedHistone variant H2AZ, exchanged for histone H2A in nucleosomesby the SWR1 complex; involved intranscriptional regulation through preventionof the spread of silent heterochromatin 0.01770.28097&radic S000005256RFA2YNL312WverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 0.017590.2801&radic&radic&radic S000004959HEF3YNL014WverifiedTranslational elongation factor EF-3; paralog of YEF3 andmember of the ABC superfamily; stimulates EF-1alpha-dependent binding of aminoacyl-tRNA bythe ribosome; normally expressed in zincdeficient cells 0.017530.27824&radic S000003723SWE1YJL187CverifiedProtein kinase that regulates the G2/M transition by inhibitionof Cdc28p kinase activity; localizes to thenucleus and to the daughter side of themother-bud neck; homolog of S. pombe Wee1p;potential Cdc28p substrate 0.017420.27771&radic&radic S000001915FAB1YFR019Wverified1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membranekinase that generates phosphatidylinositol(3,5)P2, which is involved in vacuolar sortingand homeostasis 0.017380.2767&radic&radic S000001176WSS1YHR134WverifiedSumoylated protein of unknown function, identified based ongenetic interactions with SMT3; UV-sensitivemutant phenotype and genetic interactionssuggest a role in the DNA damage response,processing stalled or collapsed replicationforks 0.017160.27448 S000003567MAD2YJL030WverifiedComponent of the spindle-assembly checkpoint complex, whichdelays the onset of anaphase in cells withdefects in mitotic spindle assembly; forms acomplex with Mad1p 0.017180.27448&radic S000001687EAP1YKL204WverifiedeIF4E-associated protein, binds eIF4E and inhibitscap-dependent translation, also functionsindependently of eIF4E to maintain geneticstability; plays a role in cell growth,implicated in the TOR signaling cascade 0.017140.27425&radic S000005251MCK1YNL307CverifiedProtein serine/threonine/tyrosine (dual-specificity) kinaseinvolved in control of chromosome segregationand in regulating entry into meiosis; relatedto mammalian glycogen synthase kinases of theGSK-3 family 0.017080.27351&radic S000004897YKU70YMR284WverifiedSubunit of the telomeric Ku complex (Yku70p-Yku80p), involvedin telomere length maintenance, structure andtelomere position effect; relocates to sites ofdouble-strand cleavage to promote nonhomologousend joining during DSB repair 0.016880.27109&radic S000000119MCM2YBL023CverifiedProtein involved in DNA replication; component of the Mcm2-7hexameric complex that binds chromatin as apart of the pre-replicative complex 0.016870.27109&radic&radic S000005242CLA4YNL298WverifiedCdc42p activated signal transducing kinase of the PAK(p21-activated kinase) family, involved inseptin ring assembly and cytokinesis; directlyphosphorylates septins Cdc3p and Cdc10p; otheryeast PAK family members are Ste20p and Skm1p 0.016830.27072&radic S000001710PAP1YKR002WverifiedPoly(A) polymerase, one of three factors required for mRNA3'-end polyadenylation, forms multiproteincomplex with polyadenylation factor I (PF I),also required for mRNA nuclear export; may alsopolyadenylate rRNAs 0.016810.27003&radic S000006368MMS1YPR164WverifiedProtein likely involved in protection againstreplication-dependent DNA damage; mutants aresensitive to methyl methanesulfonate (MMS);implicated in regulation of Ty1 transposition 0.016390.26486&radic&radic S000003896MCM22YJR135CverifiedProtein involved in minichromosome maintenance; component ofthe kinetochore; binds to centromeric DNA in aCtf19p-dependent manner 0.016390.26486&radic S000002764SPC110YDR356WverifiedInner plaque spindle pole body (SPB) component, ortholog ofhuman kendrin; involved in connecting nuclearmicrotubules to SPB; interacts withTub4p-complex and calmodulin; phosphorylated byMps1p in cell cycle-dependent manner 0.01630.26392 S000005226POP3YNL282WverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends 0.015870.25801&radic S000002918SMT3YDR510WverifiedUbiquitin-like protein of the SUMO family, conjugated to lysineresidues of target proteins; regulateschromatid cohesion, chromosome segregation,APC-mediated proteolysis, DNA replication andseptin ring dynamics 0.015830.25701&radic S000002743MSN5YDR335WverifiedKaryopherin involved in nuclear import and export; shown to beresponsible for nuclear import of replicationprotein A and for export of several proteinsincluding Swi6p, Far1p, and Pho4p; cargodissociation involves binding to RanGTP 0.015830.25701&radic S000000364CDC28YBR160WverifiedCatalytic subunit of the main cell cycle cyclin-dependentkinase (CDK); alternately associates with G1cyclins (CLNs) and G2/M cyclins (CLBs) whichdirect the CDK to specific substrates 0.015740.25623&radic S000006323CLB2YPR119WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the transition from G2 to Mphase; accumulates during G2 and M, thentargeted via a destruction box motif forubiquitin-mediated degradation by theproteasome 0.015750.25623&radic S000004603CDC5YMR001CverifiedPolo-like kinase with similarity to Xenopus Plx1 and S. pombePlo1p; found at bud neck, nucleus and SPBs; hasmultiple functions in mitosis and cytokinesisthrough phosphorylation of substrates; may be aCdc28p substrate 0.015520.25213&radic S000007590BUD25YER014C-AuncharacterizedProtein involved in bud-site selection; diploid mutants displaya random budding pattern instead of thewild-type bipolar pattern 0.015370.24998&radic&radic S000000340MEC1YBR136WverifiedGenome integrity checkpoint protein and PI kinase superfamilymember; signal transducer required for cellcycle arrest and transcriptional responsesprompted by damaged or unreplicated DNA;monitors and participates in meioticrecombination 0.015180.24747 S000002260CDC2YDL102WverifiedCatalytic subunit of DNA polymerase delta; required forchromosomal DNA replication during mitosis andmeiosis, intragenic recombination, repair ofdouble strand DNA breaks, and DNA replicationduring nucleotide excision repair (NER) 0.015210.24736&radic S000006324CLB5YPR120CverifiedB-type cyclin involved in DNA replication during S phase;activates Cdc28p to promote initiation of DNAsynthesis; functions in formation of mitoticspindles along with Clb3p and Clb4p; mostabundant during late G1 phase 0.01510.24639&radic&radic S000004329VRP1YLR337CverifiedProline-rich actin-associated protein involved in cytoskeletalorganization and cytokinesis; related tomammalian Wiskott-Aldrich syndrome protein(WASP)-interacting protein (WIP) 0.015080.24604&radic S000004467ERG6YML008CverifiedDelta(24)-sterol C-methyltransferase, converts zymosterol tofecosterol in the ergosterol biosyntheticpathway by methylating position C-24; localizedto both lipid particles and mitochondrial outermembrane 0.015050.24579&radic&radic S000002164PTC1YDL006WverifiedType 2C protein phosphatase (PP2C); inactivates the osmosensingMAPK cascade by dephosphorylating Hog1p;mutation delays mitochondrial inheritance;deletion reveals defects in precursor tRNAsplicing, sporulation and cell separation 0.014770.24078&radic S000004636ARP9YMR033WverifiedActin-related protein involved in transcriptional regulation;subunit of the chromatin remodeling Snf/Swicomplex 0.01430.2347 S000003556MPS3YJL019WverifiedEssential integral membrane protein required for spindle polebody duplication and for nuclear fusion,localizes to the spindle pole body half bridge,interacts with DnaJ-like chaperone Jem1p andwith centrin homolog Cdc31p &radic0.014240.23429 S000000908MAM1YER106WverifiedMonopolin, kinetochore associated protein involved inchromosome attachment to meiotic spindle 0.014220.23401 S000000602RVS161YCR009CverifiedAmphiphysin-like lipid raft protein; subunit of a complex(Rvs161p-Rvs167p) that regulates polarizationof the actin cytoskeleton, endocytosis, cellpolarity, cell fusion and viability followingstarvation or osmotic stress 0.014050.23112&radic&radic S000000099HTA2YBL003CverifiedOne of two nearly identical (see also HTA1) histone H2Asubtypes; core histone required for chromatinassembly and chromosome function; DNAdamage-dependent phosphorylation by Mec1pfacilitates DNA repair; acetylated by Nat4p 0.013830.22778&radic&radic S000004190YKE2YLR200WverifiedSubunit of the heterohexameric Gim/prefoldin protein complexinvolved in the folding of alpha-tubulin,beta-tubulin, and actin 0.013620.226 S000002200SIR2YDL042CverifiedConserved NAD+ dependent histone deacetylase of the Sirtuinfamily involved in regulation of lifespan;plays roles in silencing at HML, HMR,telomeres, and the rDNA locus; negativelyregulates initiation of DNA replication 0.013490.22332 S000005721SLK19YOR195WverifiedKinetochore-associated protein required for normal segregationof chromosomes in meiosis and mitosis;component of the FEAR regulatory network, whichpromotes Cdc14p release from the nucleolusduring anaphase; potential Cdc28p substrate 0.013470.22332 S000004534POB3YML069WverifiedSubunit of the heterodimeric FACT complex (Spt16p-Pob3p), whichfacilitates RNA Polymerase II transcriptionelongation through nucleosomes by destabilizingand then reassembling nucleosome structure 0.013420.2224&radic S000002726MCM21YDR318WverifiedProtein involved in minichromosome maintenance; component ofthe COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p)that bridges kinetochore subunits that are incontact with centromeric DNA and the subunitsbound to microtubules 0.013390.22186&radic S000001932CDC26YFR036WverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 0.013350.22114&radic S000000311IML3YBR107CverifiedProtein with a role in kinetochore function, localizes to theouter kinetochore in a Ctf19p-dependent manner,interacts with Chl4p and Ctf19p 0.013330.22098&radic S000006174VIK1YPL253CverifiedProtein that forms a complex with Kar3p at the spindle polebody, possible regulator of Kar3p function inmicrotubule-mediated processes; required forsister chromatid cohesion; has similarity toCik1p &radic0.013230.21924 S000001073RRM3YHR031CverifiedDNA helicase involved in rDNA replication and Ty1transposition; relieves replication fork pausesat telomeric regions; structurally andfunctionally related to Pif1p 0.013060.21639&radic&radic S000001857TUB2YFL037WverifiedBeta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p)to form tubulin dimer, which polymerizes toform microtubules 0.0130.21575 S000005205ORC5YNL261WverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing 0.012990.21575&radic S000002459DBF4YDR052CverifiedRegulatory subunit of Cdc7p-Dbf4p kinase complex, required forCdc7p kinase activity and initiation of DNAreplication; phosphorylates the Mcm2-7 familyof proteins; cell cycle regulated 0.012980.21575&radic S000000513YCL007CDubiousDubious ORF unlikely to encode a protein; overlaps verified ORF YCL005W-A; mutations in YCL007C were thought to confer sensitivity to calcofluor white, but this phenotype was later shown to be due to the defect in YCL005W-A 0.012990.21575&radic&radic S000001098RSC30YHR056CverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; non-essential gene required forregulation of ribosomal protein genes and thecell wall/stress response; highly similar toRsc3p; null mutants are osmosensitive 0.012980.21539 S000000785YEL059WDubiousHypothetical protein 0.012970.21539&radic&radic S000000648RSC6YCR052WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; essential for mitotic growth;homolog of SWI/SNF subunit Swp73p 0.012930.21396 S000003026RAD6YGL058WverifiedUbiquitin-conjugating enzyme (E2), involved in postreplicationrepair (with Rad18p), sporulation, telomeresilencing, and ubiquitin-mediated N-end ruleprotein degradation (with Ubr1p) 0.012860.21338&radic S000000264ORC2YBR060CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing; may be phosphorylated by Cdc28p 0.012760.21223&radic S000004075ARP6YLR085CverifiedActin-related protein that binds nucleosomes; a component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.012690.20949&radic S000001895DEG1YFL001WverifiedNon-essential tRNA:pseudouridine synthase, introducespseudouridines at position 38 or 39 in tRNA,important for maintenance of translationefficiency and normal cell growth, localizes toboth the nucleus and cytoplasm 0.01270.20949&radic S000006250MCM16YPR046WverifiedProtein involved in kinetochore-microtubule mediated chromosomesegregation; binds to centromere DNA 0.01260.20933&radic S000004559GIM5YML094WverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.012450.20806 S000003550MAD3YJL013CverifiedComponent of the spindle-assembly checkpoint complex, whichdelays the onset of anaphase in cells withdefects in mitotic spindle assembly; interactsphysically with the spindle checkpoint proteinsBub3p and Mad2p 0.012440.20806&radic S000004526PIF1YML061CverifiedDNA helicase involved in telomere formation and elongation;acts as a catalytic inhibitor of telomerase;also plays a role in repair and recombinationof mitochondrial DNA 0.012430.20783 S000004225YLR235CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TOP3 0.012440.20783&radic&radic S000000229YBR025CUncharacterizedHypothetical protein 0.01240.20703&radic S000000763RAD23YEL037CverifiedProtein with ubiquitin-like N terminus, recognizes and bindsdamaged DNA (with Rad4p) during nucleotideexcision repair; regulates Rad4p levels,subunit of Nuclear Excision Repair Factor 2(NEF2); homolog of human HR23A and HR23Bproteins 0.012330.20596&radic S000005976LGE1YPL055CverifiedProtein of unknown function; null mutant forms abnormally largecells 0.012340.20596&radic S000003450CRM1YGR218WverifiedMajor karyopherin, involved in export of proteins, RNAs, andribosomal subunits from the nucleus 0.012210.20412&radic S000000435SWC5YBR231CuncharacterizedProtein of unknown function, component of the SWR1 complex,which exchanges histone variant H2AZ (Htz1p)for chromatin-bound histone H2A 0.012130.20301&radic S000004505VPS71YML041Cverifiednucleosome-binding component of the SWR1 complex, whichexchanges histone variant H2AZ (Htz1p) forchromatin-bound histone H2A; required forvacuolar protein sorting 0.012060.20224&radic&radic S000005552BUB3YOR026WverifiedKinetochore checkpoint WD40 repeat protein that localizes tokinetochores during prophase and metaphase,delays anaphase in the presence of unattachedkinetochores; forms complexes with Mad1p-Bub1pand with Cdc20p, binds Mad2p and Mad3p 0.012060.20151&radic S000002178RPN4YDL020CverifiedTranscription factor that stimulates expression of proteasomegenes; Rpn4p levels are in turn regulated bythe 26S proteasome in a negative feedbackcontrol mechanism; RPN4 is transcriptionallyregulated by various stress responses 0.012020.20133&radic S000005051YAF9YNL107WverifiedSubunit of both the NuA4 histone H4 acetyltransferase complexand the SWR1 complex, may function toantagonize silencing near telomeres; interactsdirectly with Swc4p, has homology to humanleukemogenic protein AF9, contains a YEATSdomain 0.011990.20047&radic S000003209DOC1YGL240WverifiedProcessivity factor required for the ubiquitination activity ofthe anaphase promoting complex (APC), mediatesthe activity of the APC by contributing tosubstrate recognition; involved in cyclinproteolysis 0.011850.1996&radic S000000966CHD1YER164WverifiedNucleosome remodeling factor that functions in regulation oftranscription elongation; contains a chromodomain, a helicase domain and a DNA-bindingdomain; component of both the SAGA and SILKcomplexes 0.011860.1996&radic S000003461SMI1YGR229CverifiedProtein involved in the regulation of cell wall synthesis;proposed to be involved in coordinating cellcycle progression with cell wall integrity 0.011810.19904 S000003412RNR4YGR180CverifiedRibonucleotide-diphosphate reductase (RNR), small subunit; theRNR complex catalyzes the rate-limiting step indNTP synthesis and is regulated by DNAreplication and DNA damage checkpoint pathwaysvia localization of the small subunits 0.011760.19805&radic S000005783CDC31YOR257WverifiedComponent of the spindle pole body (SPB) half-bridge, requiredfor SPB duplication in mitosis and meiosis II;homolog of mammalian centrin; interacts withKar1p 0.011770.19805 S000003345DAM1YGR113WverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; Ipl1p target forregulating kinetochore-MT attachments 0.011710.19764 S000004349RSC2YLR357WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; involvedin telomere maintenance &radic0.011690.19756&radic S000003502YTA7YGR270WverifiedProtein of unknown function, member of CDC48/PAS1/SEC18 familyof ATPases, potentially phosphorylated byCdc28p 0.011670.19756&radic&radic S000001243RPN10YHR200WverifiedNon-ATPase base subunit of the 19S regulatory particle (RP) ofthe 26S proteasome; N-terminus plays a role inmaintaining the structural integrity of the RP;binds selectively to polyubiquitin chains;homolog of the mammalian S5a protein 0.011640.19725&radic S000004172SWI6YLR182WverifiedTranscription cofactor, forms complexes with DNA-bindingproteins Swi4p and Mbp1p to regulatetranscription at the G1/S transition; involvedin meiotic gene expression; localizationregulated by phosphorylation; potential Cdc28psubstrate 0.011570.19621&radic S000003034SGF73YGL066Wverified73 kDa subunit of SAGA histone acetyltransferase complex;involved in formation of the preinitiationcomplex assembly at promoters 0.011540.1957&radic S000004659BUB2YMR055CverifiedMitotic exit network regulator, forms GTPase-activatingBfa1p-Bub2p complex that binds Tem1p andspindle pole bodies, blocks cell cycleprogression before anaphase in response tospindle and kinetochore damage 0.011530.19508 S000005667ARP8YOR141CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes 0.01150.19498&radic S000001622CTK1YKL139WverifiedCatalytic (alpha) subunit of C-terminal domain kinase I(CTDK-I), which phosphorylates the C-terminalrepeated domain of the RNA polymerase II largesubunit (Rpo21p) to affect both transcriptionand pre-mRNA 3' end processing 0.011460.19435&radic S000000913SWI4YER111CverifiedDNA binding component of the SBF complex (Swi4p-Swi6p), atranscriptional activator that in concert withMBF (Mbp1-Swi6p) regulates late G1-specifictranscription of targets including cyclins andgenes required for DNA synthesis and repair 0.011420.19381&radic&radic&radic S000004202TUB4YLR212CverifiedGamma-tubulin, involved in nucleating microtubules from boththe cytoplasmic and nuclear faces of thespindle pole body 0.011380.19301&radic S000003310PAC10YGR078CverifiedPart of the heteromeric co-chaperone GimC/prefoldin complex,which promotes efficient protein folding 0.011320.19253&radic S000003814BFA1YJR053WverifiedComponent of the GTPase-activating Bfa1p-Bub2p complex involvedin multiple cell cycle checkpoint pathways thatcontrol exit from mitosis 0.011290.19228 S000003626DPB11YJL090CverifiedEssential BRCT repeat protein, required on the prereplicativecomplex at replication origins for loading DNApolymerases to initiate DNA synthesis, alsorequired for S/M checkpoint control 0.011260.19124&radic S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.011260.19124&radic S000003543CTK2YJL006CverifiedBeta subunit of C-terminal domain kinase I (CTDK-I), whichphosphorylates the C-terminal repeated domainof the RNA polymerase II large subunit (Rpo21p)to affect both transcription and pre-mRNA 3'end processing; has similarity to cyclins 0.011240.19124&radic S000002171HEX3YDL013WverifiedProtein containing a RING finger domain that interacts withSlx8p; mutant phenotypes and geneticinteractions suggest a role in sumoylation andin genome stability 0.011180.19039 S000005939CTF19YPL018WverifiedOuter kinetochore protein, required for accurate mitoticchromosome segregation; component of thekinetochore sub-complex COMA (Ctf19p, Okp1p,Mcm21p, Ame1p) that functions as a platform forkinetochore assembly 0.011180.19039 S000002482PPH3YDR075WverifiedCatalytic subunit of an evolutionarily conserved proteinphosphatase complex containing Psy2p and theregulatory subunit Psy4p; required forcisplatin resistance; involved in activation ofGln3p 0.011120.18923&radic S000003484GCN5YGR252WverifiedHistone acetyltransferase, acetylates N-terminal lysines onhistones H2B and H3; catalytic subunit of theADA and SAGA histone acetyltransferasecomplexes; founding member of the Gcn5p-relatedN-acetyltransferase superfamily 0.011020.18877&radic S000002494RRP1YDR087CverifiedEssential evolutionarily conserved nucleolar protein necessaryfor biogenesis of 60S ribosomal subunits andprocessing of pre-rRNAs to mature rRNAs,associated with several distinct 66Spre-ribosomal particles 0.011030.18877&radic S000005540RTS1YOR014WverifiedB-type regulatory subunit of protein phosphatase 2A (PP2A);homolog of the mammalian B' subunit of PP2A &radic0.0110.18855&radic S000000303YBR099CDubiousHypothetical protein 0.010950.18742&radic&radic S000004886ZDS1YMR273CverifiedProtein that interacts with silencing proteins at the telomere,involved in transcriptional silencing; has arole in localization of Bcy1p, a regulatorysubunit of protein kinase A; implicated in mRNAnuclear export 0.010940.18742 S000003175SPT16YGL207WverifiedSubunit of the heterodimeric FACT complex (Spt16p-Pob3p),facilitates RNA Polymerase II transcriptionelongation through nucleosomes by destabilizingand then reassembling nucleosome structure 0.010950.18742&radic S000005034RHO2YNL090WverifiedNon-essential small GTPase of the Rho/Rac subfamily of Ras-likeproteins, involved in the establishment of cellpolarity and in microtubule assembly 0.010920.18682&radic S000005056DBP2YNL112WverifiedEssential ATP-dependent RNA helicase of the DEAD-box proteinfamily, involved in nonsense-mediated mRNAdecay and rRNA processing 0.010880.18633&radic S000003041HSF1YGL073WverifiedTrimeric heat shock transcription factor, activates multiplegenes in response to stresses that includehyperthermia; recognizes variable heat shockelements (HSEs) consisting of inverted NGAANrepeats; posttranslationally regulated 0.010850.18617&radic S000000193BRN1YBL097WverifiedEssential protein required for chromosome condensation, likelyto function as an intrinsic component of thecondensation machinery, may influence multipleaspects of chromosome transmission and dynamics 0.010810.18575&radic S000004490TSA1YML028WverifiedUbiquitous housekeeping thioredoxin peroxidase, reducesreactive oxygen, nitrogen and sulfur speciesusing thioredoxin as hydrogen donor; mediatesredox regulation of the nuclear localization ofYap1p; deletion results in mutator phenotype 0.010720.1844&radic S000001249SKN7YHR206WverifiedNuclear response regulator and transcription factor, part of abranched two-component signaling system;required for optimal induction of heat-shockgenes in response to oxidative stress; involvedin osmoregulation 0.010690.18414&radic S000002841YDR433WDubiousHypothetical protein 0.010650.18356&radic&radic S000000065RFA1YAR007CverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 0.010660.18356&radic&radic&radic S000002421RAD61YDR014WverifiedProtein of unknown function; mutation confers radiationsensitivity 0.010640.18351&radic S000001295BCY1YIL033CverifiedRegulatory subunit of the cyclic AMP-dependent protein kinase(PKA), a component of a signaling pathway thatcontrols a variety of cellular processes,including metabolism, cell cycle, stressresponse, stationary phase, and sporulation 0.010630.1827&radic S000003428FYV8YGR196CverifiedProtein of unknown function, required for survival uponexposure to K1 killer toxin 0.010620.1827 S000001717FOX2YKR009CverifiedMultifunctional enzyme of the peroxisomal fatty acidbeta-oxidation pathway; has 3-hydroxyacyl-CoAdehydrogenase and enoyl-CoA hydrataseactivities 0.010540.18198 S000004570CAC2YML102WverifiedComponent of the chromatin assembly complex (with Rlf2p andMsi1p) that assembles newly synthesizedhistones onto recently replicated DNA, requiredfor building functional kinetochores, conservedfrom yeast to humans 0.010470.18155&radic S000000262UBP14YBR058CverifiedUbiquitin-specific protease that specifically disassemblesunanchored ubiquitin chains; involved infructose-1,6-bisphosphatase (Fbp1p)degradation; similar to human isopeptidase T 0.010470.18155&radic S000001335SPO22YIL073CverifiedMeiosis-specific protein essential for chromosome synapsis,similar to phospholipase A2, involved incompletion of nuclear divisions during meiosis;induced early in meiosis 0.010470.18138 S000001128NAM8YHR086WverifiedRNA binding protein, component of the U1 snRNP protein; mutantsare defective in meiotic recombination and information of viable spores, involved in theformation of DSBs through meiosis-specificsplicing of MER2 pre-mRNA 0.010440.18018&radic S000005735NPT1YOR209CverifiedNicotinate phosphoribosyltransferase, acts in the salvagepathway of NAD+ biosynthesis; required forsilencing at rDNA and telomeres and has a rolein silencing at mating-type loci; localized tothe nucleus 0.010430.18018&radic S000004363ROM2YLR371WverifiedGDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutationsare synthetically lethal with mutations inrom1, which also encodes a GEP 0.010360.1791 S000003998PAM18YLR008CverifiedConstituent of the mitochondrial import motor associated withthe presequence translocase, along with Ssc1p,Tim44p, Mge1p, and Pam16p; stimulates theATPase activity of Ssc1p to drive mitochondrialimport; contains a J domain 0.010330.17906 S000005336NOG2YNR053CverifiedPutative GTPase that associates with pre-60S ribosomal subunitsin the nucleolus and is required for theirnuclear export and maturation 0.010270.17826&radic S000000399MSI1YBR195CverifiedSubunit of chromatin assembly factor I (CAF-I), regulates theRAS/cAMP pathway via sequestration of Npr1pkinase; localizes to the nucleus and cytoplasm;homologous to human retinoblastoma bindingproteins RbAp48 and RbAp46 0.010240.17784&radic S000005758MGE1YOR232WverifiedProtein of the mitochondrial matrix involved in protein importinto mitochondria; acts as a cochaperone and anucleotide release factor for Ssc1p; homolog ofE. coli GrpE 0.010220.17739 S000005887PDE2YOR360CverifiedHigh-affinity cyclic AMP phosphodiesterase, component of thecAMP-dependent protein kinase signaling system,protects the cell from extracellular cAMP,contains readthrough motif surroundingtermination codon 0.010130.17625&radic S000002633HTA1YDR225WverifiedOne of two nearly identical (see also HTA2) histone H2Asubtypes; core histone required for chromatinassembly and chromosome function; DNAdamage-dependent phosphorylation by Mec1pfacilitates DNA repair; acetylated by Nat4p 0.010180.17625 S000000120NCL1YBL024WverifiedS-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase,methylates cytosine to m5C at several positionsin tRNAs and intron-containing pre-tRNAs;similar to Nop2p and human proliferationassociated nucleolar protein p120 0.010120.17585&radic S000006162CIN2YPL241CverifiedTubulin folding factor C (putative) involved in beta-tubulin(Tub2p) folding; isolated as mutant withincreased chromosome loss and sensitivity tobenomyl 0.010130.17585&radic S000004069SIC1YLR079WverifiedInhibitor of Cdc28-Clb kinase complexes that controls G1/Sphase transition, preventing premature S phaseand ensuring genomic integrity; phosphorylationtargets Sic1p for SCF(CDC4)-dependent turnover;functional homolog of mammalian Kip1 0.010080.17567&radic S000003276RME1YGR044CverifiedZinc finger protein involved in control of meiosis; preventsmeiosis by repressing IME1 expression andpromotes mitosis by activating CLN2 expression;directly repressed by a1-a2 regulator; mediatescell type control of sporulation 0.010050.17505&radic S000003124AMS1YGL156WverifiedVacuolar alpha mannosidase, involved in free oligosaccharide(fOS) degradation; delivered to the vacuole ina novel pathway separate from the secretorypathway 0.009990.1744 S000000286UBC4YBR082CverifiedUbiquitin-conjugating enzyme that mediates degradation ofshort-lived and abnormal proteins; interactswith E3-CaM in ubiquitinating calmodulin;interacts with many SCF ubiquitin proteinligases; component of the cellular stressresponse 0.009950.17376&radic S000000277RDH54YBR073WverifiedDNA-dependent ATPase, stimulates strand exchange by modifyingthe topology of double-stranded DNA; involvedin the recombinational repair of double-strandbreaks in DNA during mitosis and meiosis;proposed to be involved in crossoverinterference 0.009920.17336&radic S000003816HIT1YJR055WverifiedProtein of unknown function, required for growth at hightemperature 0.009930.17335&radic S000000063NUP60YAR002WverifiedSubunit of the nuclear pore complex (NPC), functions to anchorNup2p to the NPC in a process controlled by thenucleoplasmic concentration of Gsp1p-GTP;potential Cdc28p substrate; involved intelomere maintenance 0.00990.17264 S000002360TRM8YDL201WverifiedSubunit of a tRNA methyltransferase complex composed of Trm8pand Trm82p that catalyzes 7-methylguanosinemodification of tRNA 0.009890.17264&radic S000005952PHO85YPL031CverifiedCyclin-dependent kinase, with ten cyclin partners; involved inenvironmental stress response; inphosphate-rich conditions, Pho85p-Pho80pcomplex phosphorylates Pho4p which in turnrepresses PHO5 0.009830.17205&radic S000005080EAF7YNL136WverifiedSubunit of the NuA4 histone acetyltransferase complex, whichacetylates the N-terminal tails of histones H4and H2A 0.009780.17115&radic S000002971CDH1YGL003CverifiedCell-cycle regulated activator of the anaphase-promotingcomplex/cyclosome (APC/C), which directsubiquitination of mitotic cyclins resulting inexit from mitosis; targets the APC/C tospecific substrates including CDC20, ASE1 andCIN8 0.009760.1706 S000003416UBR1YGR184CverifiedUbiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2pto ubiquitinate substrates of the N-end rulepathway; binds to the Rpn2p, Rpt1p, and Rpt6pproteins of the 19S particle of the 26Sproteasome 0.009740.16998 S000000064SWD1YAR003WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres; WD40beta propeller superfamily member withsimilarity to mammalian Rbbp7 0.009670.16914&radic S000000974BRR2YER172CverifiedRNA-dependent ATPase RNA helicase involved in the facilitationand disruption of snRNA interactions, requiredfor disruption of U4/U6 base-pairing in nativesnRNPs to activate the spliceosome forcatalysis 0.009660.16911&radic S000005169CNM67YNL225CverifiedComponent of the spindle pole body outer plaque; required forspindle orientation and mitotic nuclearmigration 0.00960.1682 S000005795PAC1YOR269WverifiedProtein involved in nuclear migration, part of thedynein/dynactin pathway; targets dynein tomicrotubule tips, which is necessary forsliding of microtubules along bud cortex;synthetic lethal with bni1; homolog of humanLIS1 0.00960.16811&radic S000001584HSL1YKL101WverifiedNim1p-related protein kinase that regulates the morphogenesisand septin checkpoints; associates with theassembled septin filament; required along withHsl7p for bud neck recruitment,phosphorylation, and degradation of Swe1p 0.009590.16737&radic S000005551HST3YOR025WverifiedMember of the Sir2 family of NAD(+)-dependent proteindeacetylases; involved along with Hst4p intelomeric silencing, cell cycle progression,radiation resistance, genomic stability andshort-chain fatty acid metabolism 0.009580.16737&radic S000004700CTF13YMR094WverifiedSubunit of the CBF3 complex, which binds to the CDE III elementof centromeres, bending the DNA upon binding,and may be involved in sister chromatidcohesion during mitosis 0.009590.16737 S000005162MGS1YNL218WverifiedProtein with DNA-dependent ATPase and ssDNA annealingactivities involved in maintenance of genome;interacts functionally with DNA polymerasedelta; homolog of human Werner helicaseinteracting protein (WHIP) 0.009560.16737&radic&radic&radic S000003684RPA34YJL148WverifiedRNA polymerase I subunit A34.5 0.009470.16607&radic S000000290IST2YBR086CverifiedPlasma membrane protein that may be involved in osmotolerance,localizes to the mother cell in small-buddedcells and to the bud in medium- andlarge-budded cells; mRNA is transported to thebud tip by an actomyosin-driven process 0.009360.16424 S000005145PSY2YNL201CverifiedPutative subunit of an evolutionarily conserved proteinphosphatase complex containing the catalyticsubunit Pph3p and the regulatory subunit Psy4p;required for cisplatin and oxaliplatinresistance; localizes to nucleus 0.009380.16424&radic S000005241MON2YNL297CverifiedPeripheral membrane protein with a role in endocytosis andvacuole integrity, interacts with Arl1p andlocalizes to the endosome; member of the Sec7pfamily of proteins 0.009350.16424 S000001237MDM31YHR194WverifiedMitochondrial inner membrane protein with similarity to Mdm32p,required for normal mitochondrial morphologyand inheritance; interacts genetically withMMM1, MDM10, MDM12, and MDM34 0.009280.1624&radic&radic S000003141KEM1YGL173CverifiedEvolutionarily-conserved 5'-3' exonuclease component ofcytoplasmic processing (P) bodies involved inmRNA decay; plays a role inmicrotubule-mediated processes, filamentousgrowth, ribosomal RNA maturation, and telomeremaintenance 0.009290.1624 S000002840NPL3YDR432WverifiedRNA-binding protein that carries poly(A)+ mRNA from the nucleusinto the cytoplasm; phosphorylation by Sky1p inthe cytoplasm may promote release of mRNAs 0.009270.1624&radic S000004999VAC7YNL054WverifiedIntegral vacuolar membrane protein involved in vacuoleinheritance and morphology; may function toregulate Fab1p kinase activity 0.009280.1624 S000005150RTT106YNL206CverifiedProtein with a role in regulation of Ty1 transposition 0.009240.16216&radic S000005160RAP1YNL216WverifiedDNA-binding protein involved in either activation or repressionof transcription, depending on binding sitecontext; also binds telomere sequences andplays a role in telomeric position effect(silencing) and telomere structure 0.009220.16162&radic S000001406TID3YIL144WverifiedComponent of the evolutionarily conservedkinetochore-associated Ndc80 complex(Ndc80p-Nuf2p-Spc24p-Spc25p); conservedcoiled-coil protein involved in chromosomesegregation, spindle checkpoint activity,kinetochore assembly and clustering 0.009230.16162 S000002789YRA1YDR381WverifiedNuclear protein that binds to RNA and to Mex67p, required forexport of poly(A)+ mRNA from the nucleus;member of the REF (RNA and export factorbinding proteins) family; another familymember, Yra2p, can substitute for Yra1pfunction 0.009190.16113&radic S000004307NKP2YLR315WverifiedNon-essential kinetochore protein, subunit of the Ctf19 centralkinetochore complex(Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p) 0.009080.15915 S000000916BOI2YER114CverifiedProtein implicated in polar growth, functionally redundant withBoi1p; interacts with bud-emergence proteinBem1p; contains an SH3 (src homology 3) domainand a PH (pleckstrin homology) domain 0.0090.1579 S000000069BUD14YAR014CverifiedProtein involved in bud-site selection, Bud14p-Glc7p complexfunctions as a cortical regulator of dynein;diploid mutants display a random buddingpattern instead of the wild-type bipolarpattern 0.0090.15766&radic S000004200CLB4YLR210WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the G2/M transition; may beinvolved in DNA replication and spindleassembly; accumulates during S phase and G2,then targeted for ubiquitin-mediateddegradation 0.008920.15639&radic S000003054MAD1YGL086WverifiedCoiled-coil protein involved in the spindle-assemblycheckpoint; phosphorylated by Mps1p uponcheckpoint activation which leads to inhibitionof the activity of the anaphase promotingcomplex; forms a complex with Mad2p 0.008930.15639 S000005097GIM3YNL153CverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.008880.15596 S000001415RRD1YIL153WverifiedActivator of the phosphotyrosyl phosphatase activity of PP2A;regulates G1 phase progression, the G2/M phasetransition, microtubule dynamics, theosmoresponse, bud morphogenesis and DNA repair;subunit of the Tap42p-Sit4p-Rrd1p complex 0.008870.15592&radic S000004530ORC1YML065WverifiedLargest subunit of the origin recognition complex, whichdirects DNA replication by binding toreplication origins and is also involved intranscriptional silencing; may bephosphorylated by Cdc28p 0.008840.15533&radic S000000261MUM2YBR057CverifiedCytoplasmic protein essential for meiotic DNA replication andsporulation; interacts with Orc2p, which is acomponent of the origin recognition complex 0.008840.15533 S000002160NHP10YDL002CverifiedProtein related to mammalian high mobility group proteins;likely component of the INO80 complex, which isan ATP-dependent chromatin-remodeling complex 0.008840.15533&radic S000001745SPC34YKR037CverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; also localized tonuclear side of spindle pole body 0.008810.15455 S000000482DPB3YBR278WverifiedThird-largest subunit of DNA polymerase II (DNA polymeraseepsilon), required to maintain fidelity ofchromosomal replication and also forinheritance of telomeric silencing; mRNAabundance peaks at the G1/S boundary of thecell cycle 0.008810.15455&radic S000000744EAF5YEL018WuncharacterizedEsa1p-associated factor, subunit of the NuA4 acetyltransferasecomplex 0.008820.15455&radic S000004373CTF3YLR381WverifiedOuter kinetochore protein that forms a complex with Mcm16p andMcm22p; may bind the kinetochore to spindlemicrotubules 0.008820.15455 S000005091LSM7YNL147WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.008810.15455 S000003906RPS4AYJR145CverifiedProtein component of the small (40S) ribosomal subunit;mutation affects 20S pre-rRNA processing;identical to Rps4Bp and has similarity to ratS4 ribosomal protein 0.00880.15455 S000000729GIM4YEL003WverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.008810.15455 S000005293CSE2YNR010WverifiedComponent of the Med9/10 module, which is a subcomplex withinthe RNA polymerase II Mediator complex;required for regulation of RNA polymerase IIactivity 0.008710.15292&radic S000006255MAK3YPR051WverifiedCatalytic subunit of N-terminal acetyltransferase of the NatCtype; required for replication of dsRNA virus 0.008670.15284&radic S000002740IRC3YDR332WuncharacterizedHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 0.008660.15277 S000000682CSM1YCR086WverifiedNucleolar protein that forms a complex with Lrs4p which bindsMam1p at kinetochores during meiosis I tomediate accurate chromosome segregation, may beinvolved in premeiotic DNA replication;possible role in telomere maintenance 0.008620.15189 S000000022LTE1YAL024CverifiedPutative GDP/GTP exchange factor required for mitotic exit atlow temperatures; acts as a guanine nucleotideexchange factor (GEF) for Tem1p, which is a keyregulator of mitotic exit; physicallyassociates with Ras2p-GTP 0.008610.15189 S000000377UMP1YBR173CverifiedShort-lived chaperone required for correct maturation of the20S proteasome; degraded by proteasome uponcompletion of its assembly; involved inubiquitin-mediated proteolysis; mutantdefective in degradation of short-livedproteins 0.008560.15123&radic S000005938IRC15YPL017CuncharacterizedPutative S-adenosylmethionine-dependent methyltransferase ofthe seven beta-strand family; null mutantdisplays increased levels of spontaneous Rad52foci 0.008520.15068 S000004466YAP1YML007WverifiedBasic leucine zipper (bZIP) transcription factor required foroxidative stress tolerance; mediatespleiotropic drug and metal resistance;localized to the nucleus in response to thepresence of oxidants 0.008510.15068&radic S000001163LSM12YHR121WverifiedProtein of unknown function that interacts with Pbp1p and Pbp4pand associates with ribosomes; contains anRNA-binding LSM domain and an AD domain; mayplay a role in RNA processing 0.008450.14978&radic S000005016RNH201YNL072WverifiedRibonuclease H2 catalytic subunit, removes RNA primers duringOkazaki fragment synthesis; cooperates withRad27p nuclease 0.008490.14978&radic S000000533RNQ1YCL028Wverified[PIN(+)] prion, an infectious protein conformation that isgenerally an ordered protein aggregate 0.008440.14942&radic S000001762DYN1YKR054CverifiedCytoplasmic heavy chain dynein, microtubule motor protein,required for anaphase spindle elongation;involved in spindle assembly, chromosomemovement, and spindle orientation during celldivision, targeted to microtubule tips by Pac1p 0.00840.14895&radic S000002847LRS4YDR439WverifiedProtein involved in rDNA silencing; positively chargedcoiled-coil protein with limited similarity tomyosin 0.00840.14895 S000002198NAT1YDL040CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.008350.14815 S000000214HHT1YBR010WverifiedOne of two identical histone H3 proteins (see also HHT2); corehistone required for chromatin assembly,involved in heterochromatin-mediated telomericand HM silencing; regulated by acetylation,methylation, and mitotic phosphorylation 0.008340.14786&radic S000004682VPS20YMR077CverifiedMyristoylated subunit of ESCRTIII, the endosomal sortingcomplex required for transport of transmembraneproteins into the multivesicular body pathwayto the lysosomal/vacuolar lumen; cytoplasmicprotein recruited to endosomal membranes 0.008320.14758 S000006147NEW1YPL226WverifiedATP binding cassette family member; Asn/Gln-rich rich regionsupports [NU+] prion formation, susceptibilityto [PSI+] prion induction and aggregation of afragment of the human Machado-Joseph Diseaseprotein 0.008240.1466&radic S000004434SIR3YLR442CverifiedSilencing protein that interacts with Sir2p and Sir4p, andhistone H3 and H4 tails, to establish atranscriptionally silent chromatin state;required for spreading of silenced chromatin;recruited to chromatin through interaction withRap1p 0.008220.14623 S000005923SNF8YPL002CverifiedComponent of the ESCRT-II complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; appears to be functionallyrelated to SNF7; involved in glucosederepression 0.008220.14623 S000006438RPL36BYPL249C-AverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl36Ap and has similarity to ratL36 ribosomal protein; binds to 5.8 S rRNA 0.008220.14623 S000003135PMR1YGL167CverifiedHigh affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ andMn2+ transport into Golgi; involved in Ca2+dependent protein sorting and processing;mutations in human homolog ATP2C1 causeacantholytic skin condition Hailey-Haileydisease 0.008220.14623 S000005070SPC98YNL126WverifiedComponent of the microtubule-nucleating Tub4p (gamma-tubulin)complex; interacts with Spc110p at the spindlepole body (SPB) inner plaque and with Spc72p atthe SPB outer plaque 0.00820.14595 S000005430NUF2YOL069WverifiedComponent of the evolutionarily conservedkinetochore-associated Ndc80 complex(Ndc80p-Nuf2p-Spc24p-Spc25p); involved inchromosome segregation, spindle checkpointactivity and kinetochore clustering 0.008190.14535 S000006073RRD2YPL152WverifiedActivator of the phosphotyrosyl phosphatase activity of PP2A;regulates G1 phase progression, theosmoresponse and microtubule dynamics;implicated in the spindle assembly check;subunit of the Tap42p-Pph21p-Rrd2p complex 0.008190.14535&radic S000003099SNT2YGL131CverifiedDNA binding protein with similarity to the S. pombe Snt2protein 0.008140.14507&radic S000003136HUR1YGL168WuncharacterizedProtein required for hydroxyurea resistance; has possible rolesin DNA replication and maintenance of propertelomere length 0.00810.14446 S000006161HSP82YPL240CverifiedCytoplasmic chaperone (Hsp90 family) required for pheromonesignaling and negative regulation of Hsf1p;docks with the mitochondrial import receptorTom70p for preprotein delivery; interacts withco-chaperones Cns1p, Cpr6p, Cpr7p, and Sti1p 0.008090.14409 S000004264CDC46YLR274WverifiedComponent of the hexameric MCM complex, which is important forpriming origins of DNA replication in G1 andbecomes an active ATP-dependent helicase thatpromotes DNA melting and elongation whenactivated by Cdc7p-Dbf4p in S-phase 0.008080.14397&radic S000002896PAC11YDR488CverifiedDynein intermediate chain, acts in the cytoplasmic dyneinpathway, forms cortical cytoplasmic microtubulecapture site with Num1p; null mutant isdefective in nuclear migration, essential inthe absence of CIN8 0.008040.14367 S000003214GUS1YGL245WverifiedGlutamyl-tRNA synthetase (GluRS), forms a complex withmethionyl-tRNA synthetase (Mes1p) and Arc1p;complex formation increases the catalyticefficiency of both tRNA synthetases and ensurestheir correct localization to the cytoplasm 0.0080.14303 S000001055ARD1YHR013CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.007950.14226 S000003715PFD1YJL179WverifiedSubunit of heterohexameric prefoldin, which binds cytosolicchaperonin and transfers target proteins to it;involved in the biogenesis of actin and ofalpha- and gamma-tubulin 0.007940.14214 S000001924CDC14YFR028CverifiedProtein phosphatase required for mitotic exit; located in thenucleolus until liberated by the FEAR andMitotic Exit Network in anaphase, enabling itto act on key substrates to effect a decreasein CDK/B-cyclin activity and mitotic exit 0.007940.14214 S000002232BRE1YDL074CverifiedE3 ubiquitin ligase for Rad6p, required for the ubiquitinationof histone H2B, recruitment of Rad6p topromoter chromatin and subsequent methylationof histone H3 (on L4 and L79), contains RINGfinger domain 0.007920.14179&radic S000005028END3YNL084CverifiedEH domain-containing protein involved in endocytosis, actincytoskeletal organization and cell wallmorphogenesis; forms a complex with Sla1p andPan1p 0.007880.14113 S000004365VID22YLR373CverifiedGlycosylated integral membrane protein localized to the plasmamembrane; plays a role infructose-1,6-bisphosphatase (FBPase)degradation; involved in FBPase transport fromthe cytosol to Vid (vacuole import anddegradation) vesicles 0.007890.14113&radic S000004395SFP1YLR403WverifiedTranscription factor that controls expression of many ribosomebiogenesis genes in response to nutrients andstress, regulates G2/M transitions duringmitotic cell cycle and DNA-damage response,involved in cell size modulation 0.007860.14074&radic&radic&radic S000000221KAP104YBR017CverifiedTransportin, cytosolic karyopherin beta 2 involved in deliveryof heterogeneous nuclear ribonucleoproteins tothe nucleoplasm, binds rg-nuclear localizationsignals on Nab2p and Hrp1p, plays a role incell-cycle progression 0.007870.14074&radic S000005143GCR2YNL199CverifiedTranscriptional activator of genes involved in glycolysis;interacts and functions with the DNA-bindingprotein Gcr1p 0.007820.14021 S000000662RAD18YCR066WverifiedProtein involved in postreplication repair; bindssingle-stranded DNA and has single-stranded DNAdependent ATPase activity; forms heterodimerwith Rad6p; contains RING-finger motif 0.007820.14021 S000004262YCS4YLR272CverifiedNon-SMC subunit of the condensin complex(Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required forestablishment and maintenance of chromosomecondensation, chromosome segregation, chromatinbinding of condensin and silencing at themating type locus 0.007780.13937&radic S000001022ECM29YHL030WverifiedMajor component of the proteasome; tethers the proteasome coreparticle to the regulatory particle, andenhances the stability of the proteasome 0.007740.13897&radic S000003063VPS45YGL095CverifiedProtein of the Sec1p/Munc-18 family, essential for vacuolarprotein sorting; required for the function ofPep12p and the early endosome/late Golgi SNARETlg2p; essential for fusion of Golgi-derivedvesicles with the prevacuolar compartment 0.007720.13869 S000001014SPO11YHL022CverifiedMeiosis-specific protein that initiates meiotic recombinationby catalyzing the formation of double-strandbreaks in DNA via a transesterificationreaction; required for homologous chromosomepairing and synaptonemal complex formation 0.007740.13869 S000002544RGP1YDR137WverifiedSubunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) thatcatalyzes nucleotide exchange on Ypt6p 0.007720.13817 S000005966VPS16YPL045WverifiedSubunit of the homotypic vacuole fusion and vacuole proteinsorting (HOPS) complex; part of the Class C Vpscomplex essential for membrane docking andfusion at both the Golgi-to-endosome andendosome-to-vacuole stages of protein transport 0.007690.13814 S000002988GET1YGL020CverifiedSubunit of the GET complex; required for the retrieval of HDELproteins from the Golgi to the ER in an ERD2dependent fashion and for normal mitochondrialmorphology and inheritance 0.007680.13785 S000003863VPS25YJR102CverifiedComponent of the ESCRT-II complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome 0.007670.13776 S000004723SPC24YMR117CverifiedComponent of the evolutionarily conservedkinetochore-associated Ndc80 complex(Ndc80p-Nuf2p-Spc24p-Spc25p); involved inchromosome segregation, spindle checkpointactivity and kinetochore clustering 0.007640.13726 S000001531ELM1YKL048CverifiedSerine/threonine protein kinase that regulates cellularmorphogenesis, septin behavior, andcytokinesis; required for the regulation ofother kinases; forms part of the bud neck ring 0.007630.13654 S000005606DIA2YOR080WverifiedOrigin-binding F-box protein that forms an SCF ubiquitin ligasecomplex with Skp1p and Cdc53p; plays a role inDNA replication, involved in invasive andpseudohyphal growth 0.007620.13654 S000004388VPS33YLR396CverifiedATP-binding protein that is a subunit of the homotypic vacuolefusion and vacuole protein sorting (HOPS)complex; essential for membrane docking andfusion at both the Golgi-to-endosome andendosome-to-vacuole stages of protein transport 0.00760.13622 S000006005BRO1YPL084WverifiedCytoplasmic class E vacuolar protein sorting (VPS) factor thatcoordinates deubiquitination in themultivesicular body (MVB) pathway by recruitingDoa4p to endosomes 0.007590.13622 S000001540NUP120YKL057CverifiedSubunit of the Nup84p subcomplex of the nuclear pore complex(NPC), required for even distribution of NPCsaround the nuclear envelope, involved inestablishment of a normal nucleocytoplasmicconcentration gradient of the GTPase Gsp1p 0.007590.13622 S000003457AMA1YGR225WverifiedActivator of meiotic anaphase promoting complex (APC/C); Cdc20pfamily member; required for initiation of sporewall assembly; required for Clb1p degradationduring meiosis 0.007590.13622 S000004901HSH155YMR288WverifiedU2-snRNP associated splicing factor that forms extensiveassociations with the branch site-3' splicesite-3' exon region upon prespliceosomeformation; similarity to the mammalian U2snRNP-associated splicing factor SAP155 0.00760.13622&radic S000001149CDC12YHR107CverifiedComponent of the septin ring of the mother-bud neck that isrequired for cytokinesis; septins recruitproteins to the neck and can act as a barrierto diffusion at the membrane, and they comprisethe 10nm filaments seen with EM 0.007580.13607 S000006222RLF2YPR018WverifiedLargest subunit (p90) of the Chromatin Assembly Complex (CAF-I)with Cac2p and Msi1p that assembles newlysynthesized histones onto recently replicatedDNA; involved in the maintenance oftranscriptionally silent chromatin 0.007570.13578 S000001279VID28YIL017CverifiedProtein involved in proteasome-dependent catabolite degradationof fructose-1,6-bisphosphatase (FBPase);localized to the nucleus and the cytoplasm 0.007560.13578&radic S000004577ZDS2YML109WverifiedProtein that interacts with silencing proteins at the telomere,involved in transcriptional silencing; paralogof Zds1p 0.007560.13578 S000006258SMK1YPR054WverifiedMiddle sporulation-specific mitogen-activated protein kinase(MAPK) required for production of the outerspore wall layers; negatively regulatesactivity of the glucan synthase subunit Gsc2p 0.007560.13573 S000004402VIP1YLR410WverifiedProtein of unknown function probably involved in the functionof the cortical actin cytoskeleton; putativeortholog of S. pombe asp1+ 0.007530.13526 S000000184TEL1YBL088CverifiedProtein kinase primarily involved in telomere lengthregulation; contributes to cell cyclecheckpoint control in response to DNA damage;functionally redundant with Mec1p; homolog ofhuman ataxia telangiectasia (ATM) gene 0.00750.13488 S000003821CBF1YJR060WverifiedHelix-loop-helix protein that binds the motif CACRTG, which ispresent at several sites including MET genepromoters and centromere DNA element I (CDEI);required for nucleosome positioning at thismotif; targets Isw1p to DNA 0.00750.13471&radic S000005154MER1YNL210WverifiedProtein with RNA-binding motifs required for meiosis-specificmRNA splicing; required for chromosome pairingand meiotic recombination 0.007490.13471 S000002668SWM1YDR260CverifiedSubunit of the anaphase-promoting complex, which is an E3ubiquitin ligase that regulates themetaphase-anaphase transition and exit frommitosis; required for activation of thedaughter-specific gene expression and sporewall maturation 0.007490.13471 S000002903VPS3YDR495CverifiedCytoplasmic protein required for the sorting and processing ofsoluble vacuolar proteins, acidification of thevacuolar lumen, and assembly of the vacuolarH+-ATPase 0.007490.13471 S000000020FUN26YAL022CverifiedNucleoside transporter with broad nucleoside selectivity;localized to intracellular membranes 0.007470.1343 S000003151MND1YGL183CverifiedProtein required for recombination and meiotic nucleardivision; forms a complex with Hop2p, which isinvolved in chromosome pairing and repair ofmeiotic double-strand breaks 0.007460.13397 S000001293ULP2YIL031WverifiedPeptidase that deconjugates Smt3/SUMO-1 peptides from proteins,plays a role in chromosome cohesion atcentromeric regions and recovery fromcheckpoint arrest induced by DNA damage or DNAreplication defects; potential Cdc28p substrate 0.007450.13397 S000004424IMD3YLR432WverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 0.00740.1332 S000005159IES2YNL215WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.007390.13276&radic S000002897SLD5YDR489WverifiedSubunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), whichis localized to DNA replication origins andimplicated in assembly of the DNA replicationmachinery 0.007370.13276 S000004277YLR287CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene 0.007390.13276 S000000103SLA1YBL007CverifiedCytoskeletal protein binding protein required for assembly ofthe cortical actin cytoskeleton; contains 3 SH3domains; interacts with proteins regulatingactin dynamics and with proteins required forendocytosis 0.007340.13168 S000002687RNH202YDR279WverifiedRibonuclease H2 subunit, required for RNase H2 activity 0.007340.13168&radic S000005166SSU72YNL222WverifiedTranscription/RNA-processing factor that associates with TFIIBand cleavage/polyadenylation factor Pta1p;exhibits phosphatase activity on serine-5 ofthe RNA polymerase II C-terminal domain;affects start site selection in vivo 0.007270.13056 S000000514STP22YCL008CverifiedComponent of the ESCRT-I complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; homologous to the mouse and humanTsg101 tumor susceptibility gene; mutantsexhibit a Class E Vps phenotype 0.007260.13056 S000000201PKC1YBL105CverifiedProtein serine/threonine kinase essential for cell wallremodeling during growth; localized to sites ofpolarized growth and the mother-daughter budneck; homolog of the alpha, beta, and gammaisoforms of mammalian protein kinase C (PKC) 0.007280.13056 S000004908JNM1YMR294WverifiedComponent of the yeast dynactin complex, consisting of Nip100p,Jnm1p, and Arp1p; required for proper nuclearmigration and spindle partitioning duringmitotic anaphase B 0.007250.12997 S000004409VPS36YLR417WverifiedComponent of the ESCRT-II complex; contains the GLUE (GRAM LikeUbiquitin binding in EAP45) domain which isinvolved in interactions with ESCRT-I andubiquitin-dependent sorting of proteins intothe endosome 0.007230.12997 S000004849TAF9YMR236WverifiedSubunit (17 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification, similar to histone H3 0.007230.12997&radic S000004844PEP5YMR231WverifiedPeripheral vacuolar membrane protein required for proteintrafficking and vacuole biogenesis; formscomplex with Pep3p that promotes vesiculardocking/fusion reactions in conjunction withSNARE proteins, also interacts with Pep7p 0.007220.12997 S000002557NUM1YDR150WverifiedProtein required for nuclear migration, localizes to the mothercell cortex and the bud tip; may mediateinteractions of dynein and cytoplasmicmicrotubules with the cell cortex 0.007240.12997 S000004375SMC6YLR383WverifiedProtein involved in structural maintenance of chromosomes;essential subunit of Mms21-Smc5-Smc6 complex;required for growth, DNA repair,interchromosomal and sister chromatidrecombination; homologous to S. pombe rad18 0.007190.1293&radic S000001302APQ12YIL040WverifiedProtein involved in nucleocytoplasmic transport of mRNA 0.007210.1293 S000001207DNA2YHR164CverifiedEssential tripartite DNA replication factor withsingle-stranded DNA-dependent ATPase,ATP-dependent nuclease, and helicaseactivities; required for Okazaki fragmentprocessing; involved in DNA repair pathways;potential Cdc28p substrate 0.007180.12906&radic S000004230VPS34YLR240WverifiedPhosphatidylinositol 3-kinase responsible for the synthesis ofphosphatidylinositol 3-phosphate; formsmembrane-associated signal transduction complexwith Vps15p to regulate protein sorting;activated by the GTP-bound form of Gpa1p 0.007160.129 S000002314CLB3YDL155WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the G2/M transition; may beinvolved in DNA replication and spindleassembly; accumulates during S phase and G2,then targeted for ubiquitin-mediateddegradation 0.007140.12869&radic S000002384SHS1YDL225WverifiedOne of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p,Shs1p) that form a cortical filamentous collarat the mother-bud neck which is necessary fornormal morphogenesis and cytokinesis 0.007080.1278 S000004914DYN3YMR299CverifiedDynein light intermediate chain (LIC); localizes with dynein,null mutant is defective in nuclear migration 0.007090.1278 S000005083RLR1YNL139CverifiedSubunit of the THO complex, which is required for efficienttranscription elongation and involved intranscriptional elongation-associatedrecombination; required for LacZ RNA expressionfrom certain plasmids 0.007090.1278&radic&radic&radic S000001464MND2YIR025WverifiedSubunit of the anaphase-promoting complex (APC); needed formeiotic nuclear division 0.007060.12717 S000004571NUP188YML103CverifiedSubunit of the nuclear pore complex (NPC), involved in thestructural organization of the complex and ofthe nuclear envelope, also involved in nuclearenvelope permeability, interacts with Pom152pand Nic96p 0.007050.12717 S000005894SCP1YOR367WverifiedComponent of yeast cortical actin cytoskeleton, binds and crosslinks actin filaments; originally identified byits homology to calponin (contains acalponin-like repeat) but the Scp1p domainstructure is more similar to transgelin 0.007040.12695 S000002940YDR532CUncharacterizedProtein of unknown function that localizes to the nuclear side of the spindle pole body and along short spindles; deletion mutants have short telomeres; forms a complex with Spc105p 0.007020.12676 S000003972LDB18YLL049WverifiedProtein of unknown function; null mutant shows a reducedaffinity for the alcian blue dye suggesting adecreased net negative charge of the cellsurface 0.0070.12631 S000006163IQG1YPL242CverifiedEssential protein required for determination of buddingpattern, promotes localization of axial markersBud4p and Cdc12p and functionally interactswith Sec3p, localizes to the contractile ringduring anaphase, member of the IQGAP family 0.0070.12631 S000004253RED1YLR263WverifiedProtein component of the axial elements of the synaptonemalcomplex, involved in chromosome segregationduring the first meiotic division; interactswith Hop1p; required for wild-type levels ofMek1p kinase activity 0.006980.12609 S000004924GAS1YMR307WverifiedBeta-1.3-glucanosyltransferase, required for cell wallassembly; localizes to the cell surface via aglycosylphosphatidylinositol (GPI) anchor 0.006970.1259&radic S000003609JEM1YJL073WverifiedDnaJ-like chaperone required for nuclear membrane fusion duringmating, localizes to the ER membrane; exhibitsgenetic interactions with KAR2 0.006890.1244&radic&radic S000004314VPS65YLR322WdubiousDubious open reading frame, unlikely to encode a protein; notconserved in closely related Saccharomycesspecies; 75% of ORF overlaps the verified geneSFH1; deletion causes a vacuolar proteinsorting defect 0.006910.1244&radic S000005050INP52YNL106CverifiedPhosphatidylinositol 4,5-bisphosphate 5-phosphatase,synaptojanin-like protein with an N-terminalSac1 domain, plays a role in endocytosis;hyperosmotic stress causes translocation toactin patches 0.006950.1244 S000002545HPR1YDR138WverifiedSubunit of THO/TREX complexes that couple transcriptionelongation with mitotic recombination and withmRNA metabolism and export, subunit of an RNAPol II complex; regulates lifespan; involved intelomere maintenance; similar to Top1p 0.006960.1244&radic S000005041PHO23YNL097CverifiedProbable component of the Rpd3 histone deacetylase complex,involved in transcriptional regulation of PHO5;C-terminus has similarity to human candidatetumor suppressor p33(ING1) 0.006890.1244&radic S000005878MEK1YOR351CverifiedMeiosis-specific serine/threonine protein kinase, functions inmeiotic checkpoint, phosphorylates Red1p,interacts with Hop1p; required for meioticrecombination and normal spore viability 0.00690.1244 S000004876SAP30YMR263WverifiedSubunit of a histone deacetylase complex, along with Rpd3p andSin3p, that is involved in silencing attelomeres, rDNA, and silent mating-type loci;involved in telomere maintenance 0.006910.1244&radic S000006132NIP7YPL211WverifiedNucleolar protein required for 60S ribosome subunit biogenesis,constituent of 66S pre-ribosomal particles;physically interacts with Nop8p and the exosomesubunit Rrp43p 0.006890.1244&radic S000006095NIP100YPL174CverifiedLarge subunit of the dynactin complex, which is involved inpartitioning the mitotic spindle between motherand daughter cells; putative ortholog ofmammalian p150(glued) 0.006860.12393 S000004597MSC1YML128CverifiedProtein of unknown function; mutant is defective in directingmeiotic recombination events to homologouschromatids; the authentic, non-tagged proteinis detected in highly purified mitochondria inhigh-throughput studies 0.006850.12372 S000001954MEI4YER044C-AverifiedMeiosis-specific protein involved in recombination; requiredfor chromosome synapsis; required forproduction of viable spores 0.006840.12372 S000002273IWR1YDL115CuncharacterizedProtein of unknown function, deletion causes hypersensitivityto the K1 killer toxin 0.006850.12372&radic S000003038RPB9YGL070CverifiedRNA polymerase II subunit B12.6; contacts DNA; mutations affecttranscription start site; involved in telomeremaintenance 0.006820.12326&radic&radic&radic S000001738GMH1YKR030WverifiedGolgi membrane protein of unknown function, interacts withGea1p and Gea2p; required for localization ofGea2p; computational analysis suggests apossible role in either cell wall synthesis orprotein-vacuolar targeting 0.006830.12326 S000002323CDC9YDL164CverifiedDNA ligase found in the nucleus and mitochondria, an essentialenzyme that joins Okazaki fragments during DNAreplication; also acts in nucleotide excisionrepair, base excision repair, and recombination 0.006820.12322&radic S000005334BRE5YNR051CverifiedUbiquitin protease cofactor, forms deubiquitination complexwith Ubp3p that coregulates anterograde andretrograde transport between the endoplasmicreticulum and Golgi compartments; null issensitive to brefeldin A 0.006810.12298 S000001240RIX1YHR197WverifiedEssential protein involved in the processing of the ITS2 regionof the rRNA locus; required for the maturationand nuclear export of the 60S ribosomal subunit 0.006780.12254&radic S000005185ZWF1YNL241CverifiedGlucose-6-phosphate dehydrogenase (G6PD), catalyzes the firststep of the pentose phosphate pathway; involvedin adapting to oxidatve stress; homolog of thehuman G6PD which is deficient in patients withhemolytic anemia 0.006790.12254 S000004580CTK3YML112WverifiedGamma subunit of C-terminal domain kinase I (CTDK-I), whichphosphorylates the C-terminal repeated domainof the RNA polymerase II large subunit (Rpo21p)to affect both transcription and pre-mRNA 3'end processing 0.006770.12235&radic S000005174ELA1YNL230CverifiedElongin A, F-box protein that forms a heterodimer with Elc1pand participates in transcription elongation 0.006750.12206&radic S000005945RMI1YPL024WverifiedInvolved in response to DNA damage; null mutants have increasedrates of recombination and delayed S phase;interacts physically and genetically with Sgs1p(RecQ family member) and Top3p (topoisomeraseIII) 0.006740.12191&radic S000003219YGL250WUncharacterizedPutative protein of unknown function; deletion mutant results in reduced PIS1 expression and has growth defects on non-fermentable carbon sources and on minimal media; GFP-fusion protein localizes to both the cytoplasm and the nucleus 0.006720.12179&radic S000000009SWC3YAL011WverifiedProtein of unknown function, component of the SWR1 complex,which exchanges histone variant H2AZ (Htz1p)for chromatin-bound histone H2A; required forformation of nuclear-associated array of smoothendoplasmic reticulum known as karmellae 0.006730.12179&radic S000003844CSN12YJR084WverifiedSubunit of the Cop9 signalosome, which is required fordeneddylation, or removal of the ubiquitin-likeprotein Rub1p from Cdc53p (cullin); involved inadaptation to pheromone signaling 0.00670.12141&radic S000004321REC102YLR329WverifiedProtein involved in early stages of meiotic recombination;required for chromosome synapsis; forms acomplex with Rec104p and Spo11p necessaryduring the initiation of recombination 0.006710.12141 S000000979BMH1YER177Wverified14-3-3 protein, major isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others 0.006670.1208 S000000456DUT1YBR252WverifieddUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, therebypreventing incorporation of uracil into DNAduring replication; critical for themaintenance of genetic stability 0.006690.1208&radic S000005821UAF30YOR295WverifiedSubunit of UAF (upstream activation factor), which is an RNApolymerase I specific transcription stimulatoryfactor composed of Uaf30p, Rrn5p, Rrn9p,Rrn10p, histones H3 and H4; deletion decreasescellular growth rate 0.006650.12064 S000005165POP1YNL221CverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends; binds to the RPR1 RNAsubunit in Rnase P 0.006650.12053&radic S000001238NVJ1YHR195WverifiedNuclear envelope protein that interacts with the vacuolarmembrane protein Vac8p to promote formation ofnucleus-vacuole junctions during piecemealmicroautophagy of the nucleus (PMN) 0.006630.1202&radic&radic S000006249MNI2YPR045CuncharacterizedDeletion mutant is synthetically lethal with MEN mutants 0.006620.11988&radic S000004244NDL1YLR254Cuncharacterizedhomolog of nuclear distribution factor NudE, NUDEL 0.00660.1195&radic S000003410PBP1YGR178CverifiedProtein interacting with poly(A)-binding protein Pab1p; likelyinvolved in controlling the extent of mRNApolyadenylation; forms a complex with Mkt1pthat may regulate HO translation; interactswith Lsm12p in a copurification assay 0.00660.1195&radic S000006305SNT309YPR101WverifiedComponent of NineTeen complex (NTC) containing Prp19p involvedin mRNA splicing, interacts physically andgenetically with Prp19p 0.006530.1185&radic S000006111NAB3YPL190CverifiedSingle stranded DNA binding protein; acidic ribonucleoprotein;required for termination of non-poly(A)transcripts and efficient splicing; interactswith Nrd1p 0.006510.11824&radic S000000964RAD4YER162CverifiedProtein that recognizes and binds damaged DNA (with Rad23p)during nucleotide excision repair; subunit ofNuclear Excision Repair Factor 2 (NEF2);homolog of human XPC protein 0.006510.11824&radic S000000449ISW1YBR245CverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPase thatforms a complex with Ioc2p and Ioc4p toregulate transcription elongation, and acomplex with Ioc3p to repress transcriptioninitiation 0.006460.11711&radic S000000180CDC27YBL084CverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 0.006480.11711&radic S000000809PAC2YER007WverifiedMicrotubule effector required for tubulin heterodimerformation, binds alpha-tubulin, required fornormal microtubule function, null mutantexhibits cold-sensitive microtubules andsensitivity to benomyl 0.006410.11645 S000003704SET2YJL168CverifiedHistone methyltransferase with a role in transcriptionalelongation, methylates a lysine residue ofhistone H3; associates with the C-terminaldomain of Rpo21p; histone methylation activityis regulated by phosphorylation status ofRpo21p 0.006420.11645&radic S000004213IFH1YLR223CverifiedEssential protein with a highly acidic N-terminal domain; IFH1exhibits genetic interactions with FHL1,overexpression interferes with silencing attelomeres and HM loci; potential Cdc28psubstrate 0.006420.11645&radic S000003782REC107YJR021CverifiedProtein involved in early stages of meiotic recombination;involved in altering chromatin structure at DNAdouble-stranded break sites and in coordinationbetween the initiation of recombination and thefirst division of meiosis 0.006420.11645 S000002310BUD30YDL151CdubiousDubious open reading frame, unlikely to encode a protein; notconserved in closely related Saccharomycesspecies; 96% of ORF overlaps the verified geneRPC53; diploid mutant displays a weak buddingpattern phenotype in a systematic assay 0.006410.11645&radic S000006065YPL144WUncharacterizedHypothetical protein 0.006410.11645 S000000299RXT2YBR095CverifiedSubunit of the histone deacetylase Rpd3L complex; possiblyinvolved in cell fusion and invasive growth 0.00640.11617&radic S000005411GAL11YOL051WverifiedComponent of the Mediator complex; interacts with RNApolymerase II and the general transcriptionfactors to form the RNA polymerase IIholoenzyme; affects transcription by acting astarget of activators and repressors 0.006390.11617&radic&radic&radic S000007235SEM1YDR363W-AverifiedComponent of the lid subcomplex of the regulatory subunit ofthe 26S proteasome; ortholog of human DSS1 0.006370.11583&radic S000000130STU1YBL034CverifiedComponent of the mitotic spindle that binds to interpolarmicrotubules via its association withbeta-tubulin (Tub2p); required for interpolarmicrotubules to provide an outward force on thespindle poles 0.006380.11583 S000004842RRP5YMR229CverifiedProtein required for the synthesis of both 18S and 5.8S rRNA;C-terminal region is crucial for the formationof 18S rRNA and N-terminal region is requiredfor the 5.8S rRNA; component of small ribosomalsubunit (SSU) processosome 0.006350.11548 S000004252YPT6YLR262CverifiedGTPase, Ras-like GTP binding protein involved in the secretorypathway, required for fusion ofendosome-derived vesicles with the late Golgi,maturation of the vacuolar carboxypeptidase Y;has similarity to the human GTPase, Rab6 0.006350.11548 S000004029RIC1YLR039CverifiedProtein involved in retrograde transport to the cis-Golginetwork; forms heterodimer with Rgp1p that actsas a GTP exchange factor for Ypt6p; involved intranscription of rRNA and ribosomal proteingenes 0.006370.11548 S000003181SKI8YGL213CverifiedProtein involved in exosome mediated 3' to 5' mRNA degradationand translation inhibition of non-poly(A) mRNAsas well as double-strand break formation duringmeiotic recombination; required for repressingpropagation of dsRNA viruses 0.006360.11548 S000003563RNR2YJL026WverifiedRibonucleotide-diphosphate reductase (RNR), small subunit; theRNR complex catalyzes the rate-limiting step indNTP synthesis and is regulated by DNAreplication and DNA damage checkpoint pathwaysvia localization of the small subunits 0.006340.1151&radic S000005274RPD3YNL330CverifiedHistone deacetylase; regulates transcription and silencing 0.006340.1151&radic S000001601YKL118WDubiousDubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2 0.006320.11452&radic S000002172NOP1YDL014WverifiedNucleolar protein, component of the small subunit processomecomplex, which is required for processing ofpre-18S rRNA; has similarity to mammalianfibrillarin 0.006320.11452 S000003040YGL072CDubiousDubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1 0.006310.11452&radic S000006045SPC29YPL124WverifiedInner plaque spindle pole body (SPB) component, links thecentral plaque component Spc42p to the innerplaque component Spc110p; required for SPBduplication 0.006320.11452 S000004330OPI9YLR338WdubiousDubious open reading frame unlikely to encode a protein, basedon available experimental and comparativesequence data; partially overlaps the verifiedORF VRP1/YLR337C 0.006320.11452&radic S000002802RPT3YDR394WverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; substrate ofN-acetyltransferase B 0.00630.11434&radic S000000339CKS1YBR135WverifiedSubunit of the Cdc28 protein kinase, required for mitoticproteolysis, may also be involved in theproteolysis of the G1 cyclins 0.00630.11434&radic S000000678AHC2YCR082WuncharacterizedProtein of unknown function, putative transcriptionalregulator; proposed to be a Ada Histoneacetyltransferase complex component; GFP taggedprotein is localized to the cytoplasm andnucleus 0.00630.11434&radic S000004839TMA29YMR226CverifiedNADP(+)-dependent dehydrogenase; acts on serine,L-allo-threonine, and other 3-hydroxy acids;green fluorescent protein fusion proteinlocalizes to the cytoplasm and nucleus; mayinteract with ribosomes, based onco-purification experiments 0.006290.11394&radic S000001171ARP1YHR129CverifiedActin-related protein of the dynactin complex; required forspindle orientation and nuclear migration;putative ortholog of mammalian centractin 0.006270.11394 S000003393RTS3YGR161CuncharacterizedPutative component of the protein phosphatase type 2A complex 0.006290.11394&radic S000005195NRD1YNL251CverifiedRNA-binding protein that interacts with the C-terminal domainof the RNA polymerase II large subunit(Rpo21p), required for transcriptiontermination and 3' end maturation ofnonpolyadenylated RNAs 0.006290.11394&radic S000003169MCM6YGL201CverifiedProtein involved in DNA replication; component of the Mcm2-7hexameric complex that binds chromatin as apart of the pre-replicative complex 0.006260.11353&radic S000000112FUS3YBL016WverifiedMitogen-activated protein kinase involved in mating pheromoneresponse; activated by phosphorylation bySte7p; provides specificity during the matingvs. filamentous growth response byphosphorylating transcriptional and cytoplasmictargets 0.006230.11326&radic S000005677RPB2YOR151CverifiedRNA polymerase II second largest subunit B150, part of centralcore; similar to bacterial beta subunit 0.006220.11304&radic S000006439HTL1YCR020W-BverifiedSubunit of the RSC chromatin remodeling complex, a multisubunitcomplex that functions in transcriptionalregulation, chromosome stability andestablishing sister chromatid cohesion;involved in telomere maintenance 0.006220.11304&radic S000004023RSC58YLR033WverifiedRemodels the structure of chromatin complex 58KDa subunit;Chromatin Remodeling Complex subunit 0.006220.11304&radic S000002843PPM1YDR435CverifiedCarboxyl methyl transferase, methylates the C terminus of theprotein phosphatase 2A catalytic subunit(Pph21p or Pph22p), which is important forcomplex formation with regulatory subunits 0.006210.11267 S000002632HTB1YDR224CverifiedOne of two nearly identical (see HTB2) histone H2B subtypesrequired for chromatin assembly and chromosomefunction; Rad6p-Bre1p-Lge1p mediatedubiquitination regulates transcriptionalactivation, meiotic DSB formation and H3methylation 0.006170.11216&radic S000000631RRP43YCR035CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp41p, Rrp42p,Rrp4p and Dis3p; required for efficientmaturation of 5.8S, 18S and 25S rRNA 0.006170.11206&radic S000001572MIF2YKL089WverifiedKinetochore protein with homology to human CENP-C, required forstructural integrity of the spindle duringanaphase spindle elongation, interacts withhistones H2A, H2B, and H4, phosphorylated byIpl1p 0.006150.11175 S000000516SGF29YCL010CverifiedSaGa associated Factor 29kDa; Probable 29kKDa Subunit of SAGAhistone acetyltransferase complex 0.006150.11175&radic S000002718SUM1YDR310CverifiedTranscriptional repressor required for mitotic repression ofmiddle sporulation-specific genes; involved intelomere maintenance, regulated by thepachytene checkpoint 0.006160.11175&radic S000005508SPT20YOL148CverifiedSubunit of the SAGA transcriptional regulatory complex,involved in maintaining the integrity of thecomplex 0.006130.11154&radic&radic&radic S000000609YCR016WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; YCR016W is not an essential gene 0.006130.11154&radic S000001525SPC42YKL042WverifiedCentral plaque component of spindle pole body (SPB); involvedin SPB duplication, may facilitate attachmentof the SPB to the nuclear membrane 0.006120.1112 S000000187MAP2YBL091CverifiedMethionine aminopeptidase, catalyzes the cotranslationalremoval of N-terminal methionine from nascentpolypeptides; function is partially redundantwith that of Map1p 0.006110.11083&radic S000004814RAD14YMR201CverifiedProtein that recognizes and binds damaged DNA during nucleotideexcision repair; subunit of Nucleotide ExcisionRepair Factor 1 (NEF1); contains zinc fingermotif; homolog of human XPA protein 0.00610.11083&radic S000004186PWP1YLR196WverifiedProtein with WD-40 repeats involved in rRNA processing;associates with trans-acting ribosomebiogenesis factors; similar to beta-transducinsuperfamily 0.00610.11083&radic S000002518ALT2YDR111CuncharacterizedPutative alanine transaminase (glutamic pyruvic transaminase) 0.006050.10991&radic S000005415PSH1YOL054WuncharacterizedNuclear protein, putative RNA polymerase II elongation factor;isolated as Pob3p/Spt16p-binding protein 0.006070.10991&radic S000002347PPH22YDL188CverifiedCatalytic subunit of protein phosphatase 2A, functionallyredundant with Pph21p; methylated at Cterminus; forms alternate complexes withseveral regulatory subunits; involved in signaltransduction and regulation of mitosis 0.006060.10991&radic S000000253REB1YBR049CverifiedRNA polymerase I enhancer binding protein; DNA binding proteinwhich binds to genes transcribed by both RNApolymerase I and RNA polymerase II; requiredfor termination of RNA polymerase Itranscription 0.006090.10991&radic S000000041PTA1YAL043CverifiedSubunit of holo-CPF, a multiprotein complex and functionalhomolog of mammalian CPSF, required for thecleavage and polyadenylation of mRNA and snoRNA3' ends; involved in pre-tRNA processing; bindsto the phosphorylated CTD of RNAPII 0.006080.10991&radic S000001897LOC1YFR001WverifiedNuclear protein involved in asymmetric localization of ASH1mRNA; binds double-stranded RNA in vitro;constituent of 66S pre-ribosomal particles 0.006070.10991&radic&radic S000005943RAD1YPL022WverifiedSingle-stranded DNA endonuclease (with Rad10p), cleavessingle-stranded DNA during nucleotide excisionrepair and double-strand break repair; subunitof Nucleotide Excision Repair Factor 1 (NEF1);homolog of human XPF protein 0.006060.10991&radic S000003663SPT10YJL127CverifiedPutative histone acetylase, sequence-specific activator ofhistone genes, binds specifically and highlycooperatively to pairs of UAS elements in corehistone promoters, functions at or near theTATA box 0.006030.10967&radic&radic&radic S000002423DAD1YDR016CverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; is transferred to thekinetochore prior to mitosis 0.006020.10949 S000002800SPT3YDR392WverifiedSubunit of the SAGA and SAGA-like transcriptional regulatorycomplexes, interacts with Spt15p to activatetranscription of some RNA polymeraseII-dependent genes, also functions to inhibittranscription at some promoters 0.006010.10875&radic S000003049YGL081WUncharacterizedHypothetical protein 0.0060.10875 S000002603REF2YDR195WverifiedRNA-binding protein involved in the cleavage step of mRNA3'-end formation prior to polyadenylation, andin snoRNA maturation; part of holo-CPFsubcomplex APT, which associates with 3'-endsof snoRNA- and mRNA-encoding genes 0.0060.10875&radic S000006227EAF3YPR023CverifiedEsa1p-associated factor, nonessential component of the NuA4acetyltransferase complex, homologous toDrosophila dosage compensation protein MSL3 0.005990.10875&radic S000003065SRM1YGL097WverifiedNucleotide exchange factor for Gsp1p, localizes to the nucleus,required for nucleocytoplasmic trafficking ofmacromolecules; potentially phosphorylated byCdc28p 0.005980.10851&radic S000003388PTI1YGR156WverifiedPta1p Interacting protein 0.005970.10837&radic S000003507RTT102YGR275WverifiedComponent of both the SWI/SNF and RSC chromatin remodelingcomplexes, suggested role in chromosomemaintenance; possible weak regulator of Ty1transposition 0.005950.10821&radic S000004280GUF1YLR289WverifiedMitochondrial GTPase of unknown function, similar to E. colielongation factor-type GTP-binding protein LepAand to LK1236.1 from Caenorhabditis elegans 0.005950.10798 S000000013NTG1YAL015CverifiedDNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involvedin base excision repair, localizes to thenucleus and mitochondrion 0.005950.10798&radic S000001900RPN11YFR004WverifiedMetalloprotease subunit of the 19S regulatory particle of the26S proteasome lid; couples thedeubiquitination and degradation of proteasomesubstrates 0.005940.10798&radic S000001542MPE1YKL059CverifiedEssential conserved subunit of CPF (cleavage andpolyadenylation factor), plays a role in 3' endformation of mRNA via the specific cleavage andpolyadenylation of pre-mRNA, contains aputative RNA-binding zinc knuckle motif 0.005930.10776&radic S000001298CST6YIL036WverifiedBasic leucine zipper (bZIP) transcription factor of theATF/CREB family, activates transcription ofgenes involved in utilization of non-optimalcarbon sources; involved in telomeremaintenance 0.005930.10776&radic S000000406CDC47YBR202WverifiedComponent of the hexameric MCM complex, which is important forpriming origins of DNA replication in G1 andbecomes an active ATP-dependent helicase thatpromotes DNA melting and elongation whenactivated by Cdc7p-Dbf4p in S-phase 0.005910.1071&radic&radic S000006177CLN2YPL256CverifiedG1 cyclin involved in regulation of the cell cycle; activatesCdc28p kinase to promote the G1 to S phasetransition; late G1 specific expression dependson transcription factor complexes, MBF(Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) 0.00590.1071&radic S000004722ASC1YMR116CverifiedWD repeat protein (G-beta like protein) involved in translationregulation; required for repression of Gcn4pactivity in the absence of amino-acidstarvation; core component of the ribosome;ortholog of mammalian RACK1 0.005910.1071 S000001597APN1YKL114CverifiedMajor apurinic/apyrimidinic endonuclease, 3'-repair diesteraseinvolved in repair of DNA damage by oxidationand alkylating agents; also functions as a3'-5' exonuclease to repair7,8-dihydro-8-oxodeoxyguanosine 0.00590.1071&radic S000004970SSN8YNL025CverifiedCyclin-like component of the RNA polymerase II holoenzyme,involved in phosphorylation of the RNApolymerase II C-terminal domain; involved inglucose repression and telomere maintenance 0.005920.1071&radic S000003203ADE5,7YGL234WverifiedBifunctional enzyme of the 'de novo' purine nucleotidebiosynthetic pathway, contains aminoimidazoleribotide synthetase and glycinamide ribotidesynthetase activities 0.005910.1071 S000003873NNF1YJR112WverifiedEssential component of the MIND kinetochore complex (Mtw1pIncluding Nnf1p-Nsl1p-Dsn1p) which joinskinetochore subunits contacting DNA to thosecontacting microtubules; required for accuratechromosome segregation 0.005920.1071 S000003424TDH3YGR192CverifiedGlyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involvedin glycolysis and gluconeogenesis; tetramerthat catalyzes the reaction ofglyceraldehyde-3-phosphate to 1,3bis-phosphoglycerate; detected in the cytoplasmand cell-wall 0.005880.10617&radic S000004045SPT8YLR055CverifiedSubunit of the SAGA transcriptional regulatory complex but notpresent in SAGA-like complex SLIK/SALSA,required for SAGA-mediated inhibition at somepromoters 0.005880.10617&radic S000002255RPN6YDL097CverifiedEssential, non-ATPase regulatory subunit of the 26S proteasomelid required for the assembly and activity ofthe 26S proteasome; the human homolog (S9protein) partially rescues Rpn6p depletion 0.005870.10617&radic S000004470SPT5YML010WverifiedProtein that forms a complex with Spt4p and mediates bothactivation and inhibition of transcriptionelongation; Spt4p-Spt5p complex also plays arole in pre-mRNA processing 0.005830.10576&radic S000003905MGM101YJR144WverifiedProtein involved in mitochondrial genome maintenance; componentof the mitochondrial nucleoid, required for therepair of oxidative mtDNA damage 0.005820.10495 S000005724BFR1YOR198CverifiedComponent of mRNP complexes associated with polyribosomes;implicated in secretion and nuclearsegregation; multicopy suppressor of BFA(Brefeldin A) sensitivity 0.005810.10495 S000001532CSE4YKL049CverifiedCentromere protein that resembles histones, required for properkinetochore function; homolog of human CENP-A 0.005820.10495&radic S000003368LSB1YGR136WverifiedProtein containing an N-terminal SH3 domain; binds Las17p,which is a homolog of human Wiskott-AldrichSyndrome protein involved in actin patchassembly and actin polymerization 0.005810.10495&radic S000003279TFC4YGR047CverifiedOne of six subunits of the RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part of theTauA domain of TFIIIC that binds BoxA DNApromoter sites of tRNA and similar genes; hasTPR motifs; human homolog is TFIIIC-102 0.005780.10438&radic S000000779MAK10YEL053CverifiedNon-catalytic subunit of N-terminal acetyltransferase of theNatC type, required for replication of dsRNAvirus; expression is glucose-repressible 0.005780.10438 S000004697NPL6YMR091CverifiedComponent of the RSC chromatin remodeling complex; interactswith Rsc3p, Rsc30p, Ldb7p, and Htl1p to form amodule important for a broad range of RSCfunctions; involved in nuclear protein importand maintenance of proper telomere length 0.005750.10394&radic S000004166RFX1YLR176CverifiedProtein involved in DNA damage and replication checkpointpathway; recruits repressors Tup1p and Cyc8p topromoters of DNA damage-inducible genes;similar to a family of mammalian DNA bindingRFX1-4 proteins 0.005730.10357&radic S000005133SRP1YNL189WverifiedKaryopherin alpha homolog, forms a dimer with karyopherin betaKap95p to mediate import of nuclear proteins,binds the nuclear localization signal of thesubstrate during import; may also play a rolein regulation of protein degradation 0.00570.10271 S000006067NOP53YPL146CverifiedNucleolar protein; involved in biogenesis of the 60S subunit ofthe ribosome; interacts with rRNA processingfactors Cbf5p and Nop2p; null mutant is viablebut growth is severely impaired 0.00570.10271&radic S000004711PGM2YMR105CverifiedPhosphoglucomutase, catalyzes the conversion fromglucose-1-phosphate to glucose-6-phosphate,which is a key step in hexose metabolism;functions as the acceptor for aGlc-phosphotransferase 0.005710.10271&radic S000005077FYV6YNL133CverifiedProtein of unknown function, required for survival uponexposure to K1 killer toxin; proposed toregulate double-strand break repair vianon-homologous end-joining 0.005710.10271&radic&radic S000003583RTT101YJL047CverifiedCullin subunit of a Roc1p-dependent E3 ubiquitin ligasecomplex; deletion phenotype suggests a role inanaphase progression; interacts with Mms22p andimplicated in Mms22-dependent DNA repair;modified by the ubiquitin-like protein, Rub1p 0.005670.10215&radic&radic&radic S000000453ARO4YBR249Cverified3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase,catalyzes the first step in aromatic amino acidbiosynthesis and is feedback-inhibited bytyrosine or high concentrations ofphenylalanine or tryptophan 0.005660.10188&radic S000002697RTT103YDR289CverifiedProtein that interacts with exonuclease Rat1p and Rai1p andplays a role in transcription termination byRNA polymerase II, has an RPR domain(carboxy-terminal domain interacting domain);also involved in regulation of Ty1transposition 0.005660.10188 S000005180SIN4YNL236WverifiedSubunit of the Mediator complex; interacts with the RNApolymerase II holoenzyme to postively ornegatively regulate transcription; dispensiblefor basal transcription 0.005660.10188&radic S000001444IST3YIR005WverifiedComponent of the U2 snRNP, required for the first catalyticstep of splicing and for spliceosomal assembly;interacts with Rds3p and is required forMer1p-activated splicing 0.005650.10188&radic S000003947SSA2YLL024CverifiedATP binding protein involved in protein folding and vacuolarimport of proteins; member of heat shockprotein 70 (HSP70) family; associated with thechaperonin-containing T-complex; present in thecytoplasm, vacuolar membrane and cell wall 0.00560.1005&radic S000001229KOG1YHR186CverifiedSubunit of TORC1, a rapamycin-sensitive complex involved ingrowth control that contains Tor1p or Tor2p,Lst8p and Tco89p; contains four HEAT repeatsand seven WD-40 repeats; may act as a scaffoldprotein to couple TOR and its effectors 0.005620.1005 S000003827TOR1YJR066WverifiedPIK-related protein kinase and rapamycin target; subunit ofTORC1, a complex that controls growth inresponse to nutrients by regulatingtranslation, transcription, ribosomebiogenesis, nutrient transport and autophagy;involved in meiosis 0.00560.1005 S000006022ELP4YPL101WverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;required for Elongator structural integrity 0.005620.1005 S000000213HHF1YBR009CverifiedOne of two identical histone H4 proteins (see also HHF2); corehistone required for chromatin assembly andchromosome function; contributes to telomericsilencing; N-terminal domain involved inmaintaining genomic integrity 0.005580.10049&radic S000005638CEX1YOR112WverifiedCytoplasmic component of the nuclear aminoacylation-dependenttRNA export pathway; interacts with nuclearpore component Nup116p; copurifies with tRNAexport receptors Los1p and Msn5p, as well aseIF-1a and the RAN GTPase Gsp1p 0.005540.09934 S000006082BEM4YPL161CverifiedProtein involved in establishment of cell polarity and budemergence; interacts with the Rho1p smallGTP-binding protein and with the Rho-typeGTPase Cdc42p; involved in maintenance ofproper telomere length 0.005510.09866&radic S000003949HSP104YLL026WverifiedHeat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p(Hsp70) to refold and reactivate previouslydenatured, aggregated proteins; responsive tostresses including: heat, ethanol, and sodiumarsenite; involved in [PSI+] propagation 0.005440.0975&radic S000004523SML1YML058WverifiedRibonucleotide reductase inhibitor involved in regulating dNTPproduction; regulated by Mec1p and Rad53pduring DNA damage and S phase 0.005470.0975&radic&radic S000004239YEF3YLR249WverifiedTranslational elongation factor, stimulates the binding ofaminoacyl-tRNA (AA-tRNA) to ribosomes byreleasing EF-1 alpha from the ribosomalcomplex; contains two ABC cassettes; binds andhydrolyses ATP 0.005470.0975&radic S000001948RPN12YFR052WverifiedSubunit of the 19S regulatory particle of the 26S proteasomelid; synthetically lethal with RPT1, which isan ATPase component of the 19S regulatoryparticle; physically interacts with Nob1p andRpn3p 0.005410.09675&radic S000004736POM152YMR129WverifiedNuclear pore membrane glycoprotein; may be involved induplication of nuclear pores and nuclear porecomplexes during S-phase; 0.005410.09675 S000005831ISW2YOR304WverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPasecomponent that, with Itc1p, forms a complexrequired for repression of a-specific genes,INO1, and early meiotic genes during mitoticgrowth 0.005410.09675&radic S000001390MET18YIL128WverifiedDNA repair and TFIIH regulator, required for both nucleotideexcision repair (NER) and RNA polymerase II(RNAP II) transcription; involved in telomeremaintenance 0.005430.09675&radic S000000100UTP20YBL004WverifiedComponent of the small-subunit (SSU) processome, which isinvolved in the biogenesis of the 18S rRNA 0.005430.09675 S000000865THO1YER063WverifiedProtein of unknown function; overproduction suppresses thetranscriptional defect caused by an hpr1mutation 0.005370.09618&radic S000006219YPR015CUncharacterizedPutative protein of unknown function 0.005320.09473 S000000493SNF5YBR289WverifiedSubunit of the SWI/SNF chromatin remodeling complex involved intranscriptional regulation; functionsinterdependently in transcriptional activationwith Snf2p and Snf6p 0.005320.09473&radic&radic S000001123LRP1YHR081WverifiedSubstrate-specific nuclear cofactor for exosome activity in theprocessing of stable RNAs; required fortelomere length maintenance; homolog ofmammalian nuclear matrix protein C1D involvedin regulation of DNA repair and recombination 0.00530.09473 S000001686TOR2YKL203CverifiedPIK-related protein kinase and rapamycin target; subunit ofTORC1, a complex that regulates growth inresponse to nutrients and TORC2, a complex thatregulates cell-cycle dependent polarization ofthe actin cytoskeleton; involved in meiosis 0.00530.09471 S000000274ALG14YBR070CverifiedComponent of UDP-GlcNAc transferase required for the secondstep of dolichyl-linked oligosaccharidesynthesis; anchors the catalytic subunit Alg13pto the ER membrane; similar to bacterial andhuman glycosyltransferases 0.005260.09359&radic&radic S000003043MPS2YGL075CverifiedEssential membrane protein localized at the nuclear envelopeand spindle pole body (SPB), required forinsertion of the newly duplicated SPB into thenuclear envelope; potentially phosphorylated byCdc28p 0.005270.09359 S000000360SLI15YBR156CverifiedSubunit of the Ipl1p-Sli15p-Bir1p complex that regulateskinetochore-microtubule attachments, activationof the spindle tension checkpoint, and mitoticspindle disassembly; regulates the activity andlocalization of the Ipl1p aurora kinase 0.005240.09308&radic S000001015RMD11YHL023CverifiedProtein required for sporulation 0.005210.09255 S000002723IPK1YDR315CverifiedInositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear proteinrequired for synthesis of1,2,3,4,5,6-hexakisphosphate (phytate), whichis integral to cell function; has 2 motifsconserved in other fungi; ipk1 gle1 doublemutant is inviable 0.005210.09255 S000003207CSE1YGL238WverifiedNuclear envelope protein that mediates the nuclear export ofimportin alpha (Srp1p), homolog of metazoan CASprotein, required for accurate chromosomesegregation 0.005190.09233&radic S000001562SMY1YKL079WverifiedProtein that interacts with Myo2p, proposed to be involved inexocytosis; N-terminal domain is related to themotor domain of kinesins 0.005170.09216 S000004140STM1YLR150WverifiedProtein that binds G4 quadruplex and purine motif triplexnucleic acid; acts with Cdc13p to maintaintelomere structure; interacts with ribosomesand subtelomeric Y' DNA; multicopy suppressorof tom1 and pop2 mutations 0.005130.09138 S000002832DYN2YDR424CverifiedCytoplasmic light chain dynein, microtubule motor protein 0.005130.09138 S000000739VAC8YEL013WverifiedPhosphorylated vacuolar membrane protein that interacts withAtg13p, required for the cytoplasm-to-vacuoletargeting (Cvt) pathway; interacts with Nvj1pto form nucleus-vacuole junctions 0.005110.09082 S000001208PRP8YHR165CverifiedComponent of the U4/U6-U5 snRNP complex, involved in the secondcatalytic step of splicing 0.005120.09082&radic S000003941DPS1YLL018CverifiedCytoplasmic aspartyl-tRNA synthetase, homodimeric enzyme thatcatalyzes the specific aspartylation oftRNA(Asp); class II aminoacyl tRNA synthetase;binding to its own mRNA may conferautoregulation 0.00510.09082 S000001153UBA4YHR111WverifiedProtein that activates Urm1p before its conjugation to proteins(urmylation); one target is the thioredoxinperoxidase Ahp1p, suggesting a role ofurmylation in the oxidative stress response 0.005090.09053 S000003849BIR1YJR089WverifiedEssential chromosomal passenger protein involved incoordinating cell cycle events for properchromosome segregation; C-terminal region bindsSli15p, and the middle region, uponphosphorylation, localizes Cbf2p to the spindleat anaphase 0.005080.09041&radic S000000485DUG2YBR281CuncharacterizedProtein involved in alternative pathway of glutathionedegradation; green fluorescent protein(GFP)-fusion protein localizes to the cytoplasmand nucleus; YBR281C is not an essential gene 0.005040.08945&radic&radic S000004880PPA2YMR267WverifiedMitochondrial inorganic pyrophosphatase, required formitochondrial function and possibly involved inenergy generation from inorganic pyrophosphate 0.005020.08942 S000001141TRA1YHR099WverifiedSubunit of SAGA and NuA4 histone acetyltransferase complexes;interacts with acidic activators (e.g., Gal4p)which leads to transcription activation;similar to human TRRAP, which is a cofactor forc-Myc mediated oncogenic transformation 0.005020.08942 S000001887BLM10YFL007WverifiedProteosome activator subunit; found in association with coreparticles, with and without the 19S regulatoryparticle; required for resistance to bleomycin,may be involved in protecting against oxidativedamage; similar to mammalian PA200 0.005020.08942&radic S000002791NKP1YDR383CverifiedNon-essential kinetochore protein, subunit of the Ctf19 centralkinetochore complex(Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p) 0.005020.08935 S000005978SUR1YPL057CverifiedProbable catalytic subunit of a mannosylinositolphosphorylceramide (MIPC) synthase, forms acomplex with probable regulatory subunit Csg2p;function in sphingolipid biosynthesis isoverlapping with that of Csh1p 0.005010.08907 S000002245LUC7YDL087CverifiedEssential protein associated with the U1 snRNP complex;splicing factor involved in recognition of 5'splice site 0.0050.08896&radic S000002684PMP3YDR276CverifiedSmall plasma membrane protein related to a family of plantpolypeptides that are overexpressed under highsalt concentration or low temperature, notessential for viability, deletion causeshyperpolarization of the plasma membranepotential 0.004990.08871 S000003818CDC8YJR057WverifiedThymidylate and uridylate kinase, functions in de novobiosynthesis of pyrimidinedeoxyribonucleotides; converts dTMP to dTDP anddUMP to dUTP; essential for mitotic and meioticDNA replication; homologous to S. pombe Tmp1p 0.004980.08871 S000005998YPL077CUncharacterizedHypothetical protein 0.004980.08828 S000001456MET28YIR017CverifiedTranscriptional activator in the Cbf1p-Met4p-Met28p complex,participates in the regulation of sulfurmetabolism 0.004970.08828&radic S000004478PPZ1YML016CverifiedSerine/threonine protein phosphatase Z, isoform of Ppz2p;involved in regulation of potassium transport,which affects osmotic stability, cell cycleprogression, and halotolerance 0.004940.0878 S000006110GUP2YPL189WverifiedProbable membrane protein with a possible role in protonsymport of glycerol; member of the MBOAT familyof putative membrane-bound O-acyltransferases;Gup1p homolog 0.004910.08739 S000004208YLR218CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR218C is not essential; mutants exhibit glycogen storage defects and growth defects on a non-fermentable carbon source 0.004920.08739&radic&radic S000004376IKI3YLR384CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;maintains structural integrity of Elongator;homolog of human IKAP, mutations in which causefamilial dysautonomia (FD) 0.00490.08701 S000001946PRE4YFR050Cverified20S proteasome beta-type subunit 0.00490.08701&radic S000000206RER2YBR002CverifiedCis-prenyltransferase involved in dolichol synthesis;participates in endoplasmic reticulum (ER)protein sorting 0.004890.08693 S000001557MUD2YKL074CverifiedProtein involved in early pre-mRNA splicing; component of thepre-mRNA-U1 snRNP complex, the commitmentcomplex; interacts with Msl5p/BBP splicingfactor and Sub2p; similar to metazoan splicingfactor U2AF65 0.004890.08684&radic S000002672AKR1YDR264CverifiedPalmitoyl transferase involved in protein palmitoylation; actsas a negative regulator of pheromone responsepathway; required for endocytosis of pheromonereceptors; involved in cell shape control;contains ankyrin repeats 0.004880.08684&radic&radic S000003321NNF2YGR089WuncharacterizedProtein that exhibits physical and genetic interactions withRpb8p, which is a subunit of RNA polymerases I,II, and III; computational analysis oflarge-scale protein-protein interaction datasuggests a role in chromosome segregation 0.004870.08591 S000003997NSE1YLR007WverifiedEssential subunit of the Mms21-Smc5-Smc6 complex; nuclearprotein required for DNA repair and growth 0.004850.08591 S000001164YHR122WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; may be involved in transcription; YHR122W is an essential gene 0.004850.08591 S000000011DEP1YAL013WverifiedTranscriptional modulator involved in regulation of structuralphospholipid biosynthesis genes andmetabolically unrelated genes, as well asmaintenance of telomeres, mating efficiency,and sporulation 0.004880.08591 S000004907YMR293CUncharacterizedPutative protein similar to bacterial glutamyl-tRNA amidotransferases; may be involved in aerobic respiration; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR293C is not an essential gene 0.004850.08591 S000006240VMA13YPR036WverifiedSubunit H of the eight-subunit V1 peripheral membrane domain ofthe vacuolar H+-ATPase (V-ATPase), anelectrogenic proton pump found throughout theendomembrane system; serves as an activator ora structural stabilizer of the V-ATPase 0.004860.08591 S000000520BUD3YCL014WverifiedProtein involved in bud-site selection and required for axialbudding pattern; localizes with septins to budneck in mitosis and may constitute an axiallandmark for next round of budding 0.004860.08591 S000004987BOP3YNL042WverifiedProtein of unknown function, potential Cdc28p substrate;overproduction suppresses a pam1 slv3 doublenull mutation and confers resistance tomethylmercury 0.004820.0855&radic S000004612YMR010WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1 0.004830.0855 S000005850PRO2YOR323CverifiedGamma-glutamyl phosphate reductase, catalyzes the second stepin proline biosynthesis 0.004820.0855&radic&radic S000000957BEM2YER155CverifiedRho GTPase activating protein (RhoGAP) involved in the controlof cytoskeleton organization and cellularmorphogenesis; required for bud emergence 0.004830.0855 S000003432ELP2YGR200CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;target of Kluyveromyces lactis zymocin 0.00480.08512 S000001769KTR2YKR061WverifiedMannosyltransferase involved in N-linked protein glycosylation;member of the KRE2/MNT1 mannosyltransferasefamily 0.004780.08479 S000003927ORC3YLL004WverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing 0.004780.08479 S000004187SIK1YLR197WverifiedEssential evolutionarily-conserved nucleolar protein componentof the box C/D snoRNP complexes that direct2'-O-methylation of pre-rRNA during itsmaturation; overexpression causes spindleorientation defects 0.004760.08405 S000001100MED6YHR058CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation 0.004770.08405&radic S000005187SLA2YNL243WverifiedTransmembrane actin-binding protein involved in membranecytoskeleton assembly and cell polarization;adaptor protein that links actin to clathrinand endocytosis; present in the actin corticalpatch of the emerging bud tip; dimer in vivo 0.004770.08405 S000002186MPS1YDL028CverifiedDual-specificity kinase required for spindle pole body (SPB)duplication and spindle checkpoint function;substrates include SPB proteins Spc42p,Spc110p, and Spc98p, mitotic exit networkprotein Mob1p, and checkpoint protein Mad1p 0.004750.08405 S000002613MSC2YDR205WverifiedMember of the cation diffusion facilitator family, localizes tothe endoplasmic reticulum and nucleus;mutations affect the cellular distribution ofzinc and also confer defects in meioticrecombination between homologous chromatids 0.004780.08405 S000003202SEC15YGL233WverifiedEssential 113kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which mediates polarized targeting ofvesicles to active sites of exocytosis; Sec15passociates with Sec4p and vesicles 0.004750.08405 S000004206CPR6YLR216CverifiedPeptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzesthe cis-trans isomerization of peptide bondsN-terminal to proline residues; binds to Hsp82pand contributes to chaperone activity 0.004750.08405 S000002307NOP14YDL148CverifiedNucleolar protein, forms a complex with Noc4p that mediatesmaturation and nuclear export of 40S ribosomalsubunits; also present in the small subunitprocessome complex, which is required forprocessing of pre-18S rRNA 0.004730.08386 S000000955PET122YER153CverifiedSpecific translational activator for the COX3 mRNA that actstogether with Pet54p and Pet494p; located inthe mitochondrial inner membrane 0.004710.08347 S000004339KAP95YLR347CverifiedKaryopherin beta, forms a dimeric complex with Srp1p (Kap60p)that mediates nuclear import of cargo proteinsvia a nuclear localization signal (NLS),interacts with nucleoporins to guide transportacross the nuclear pore complex 0.004710.08347 S000002275CYK3YDL117WverifiedSH3-domain protein located in the mother-bud neck and thecytokinetic actin ring; mutant phenotype andgenetic interactions suggest a role incytokinesis 0.004690.08283 S000003179NCS6YGL211WuncharacterizedProtein with a role in urmylation and in invasive andpseudohyphal growth; inhibits replication ofBrome mosaic virus in S. cerevisiae, which is amodel system for studying replication ofpositive-strand RNA viruses in their naturalhosts 0.004690.08283 S000006007ELP3YPL086CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;exhibits histone acetyltransferase activitythat is directed to histones H3 and H4;disruption confers resistance to K. lactiszymotoxin 0.004680.08283 S000001926MET10YFR030WverifiedSubunit alpha of assimilatory sulfite reductase, which isresponsible for the conversion of sulfite intosulfide 0.004690.08283 S000006335NAT3YPR131CverifiedCatalytic subunit of the NatB N-terminal acetyltransferase,which catalyzes acetylation of theamino-terminal methionine residues of allproteins beginning with Met-Asp or Met-Glu andof some proteins beginning with Met-Asn orMet-Met 0.004670.08252&radic&radic S000002201PRP11YDL043CverifiedSubunit of the SF3a splicing factor complex, required forspliceosome assembly 0.004670.08252&radic S000002796RVS167YDR388WverifiedActin-associated protein, subunit of a complex(Rvs161p-Rvs167p) involved in regulation ofactin cytoskeleton, endocytosis, and viabilityfollowing starvation or osmotic stress; homologof mammalian amphiphysin 0.004650.08234&radic&radic S000005235MID1YNL291CverifiedN-glycosylated integral membrane protein of the ER membrane andplasma membrane, functions as astretch-activated Ca2+-permeable cation channelrequired for Ca2+ influx stimulated bypheromone; interacts with Cch1p; forms anoligomer 0.004650.08234 S000003033ALG2YGL065CverifiedPresumed early mannosyltransferase involved in the N-linkedglycosylation pathway; alg2 mutants exhibittemperature-sensitive growth and abnormalaccumulation of the lipid-linkedoligosaccharide Man2GlcNAc2-PP-Dol 0.004640.08228 S000005853MYO2YOR326WverifiedOne of two type V myosin motors (along with MYO4) involved inactin-based transport of cargos; required forthe polarized delivery of secretory vesicles,the vacuole, late Golgi elements, peroxisomes,and the mitotic spindle 0.004640.08228 S000004415ATG17YLR423CverifiedProtein that interacts with and is required for activation ofApg1p protein kinase; involved in autophagy butnot in the Cvt (cytoplasm to vacuole targeting)pathway 0.004630.0819 S000002165RPT2YDL007WverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; required for normalpeptide hydrolysis by the core 20S particle 0.004630.0819&radic S000000752SNU13YEL026WverifiedRNA binding protein, part of U3 snoRNP involved in rRNAprocessing, part of U4/U6-U5 tri-snRNP involvedin mRNA splicing, similar to human 15.5Kprotein 0.004630.0819 S000004885SCS7YMR272CverifiedSphingolipid alpha-hydroxylase, functions in thealpha-hydroxylation of sphingolipid-associatedvery long chain fatty acids, has bothcytochrome b5-like and hydroxylase/desaturasedomains, not essential for growth 0.004620.0819&radic&radic S000004475SEL1YML013WverifiedProtein involved in ER-associated protein degradation; proposedto coordinate the assembly of proteins involvedin ERAD; contains a UBX (ubiquitin regulatoryX) domain and a ubiquitin-associated (UBA)domain 0.004620.0819 S000001756NAP1YKR048CverifiedProtein that interacts with mitotic cyclin Clb2p; required forthe regulation of microtubule dynamics duringmitosis; controls bud morphogenesis; involvedin the transport of H2A and H2B histones to thenucleus 0.004610.08177 S000003576NUP192YJL039CverifiedEssential structural subunit of the nuclear pore complex (NPC),localizes to the nuclear periphery of nuclearpores, homologous to human p205 0.004590.08151 S000004929ELP6YMR312WverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;required for Elongator structural integrity 0.00460.08151 S000004180MMR1YLR190WverifiedPhosphorylated protein of the mitochondrial outer membrane,localizes only to mitochondria of the bud;interacts with Myo2p to mediate mitochondrialdistribution to buds; mRNA is targeted to thebud via the transport system involving She2p 0.004590.08134 S000004984BDP1YNL039WverifiedEssential subunit of RNA polymerase III transcription factor(TFIIIB), which is involved in transcription ofgenes encoding tRNAs, 5S rRNA, U6 snRNA, andother small RNAs 0.004580.08104&radic S000005192RPA49YNL248CverifiedRNA polymerase I subunit A49 0.004580.08104 S000001157DMA1YHR115CverifiedProtein involved in regulating spindle position andorientation, functionally redundant with Dma2p;homolog of S. pombe Dma1 and H. sapiens Chfr 0.004570.08055 S000003089GPG1YGL121CverifiedProposed gamma subunit of the heterotrimeric G protein thatinteracts with the receptor Grp1p; involved inregulation of pseudohyphal growth; requiresGpb1p or Gpb2p to interact with Gpa2p 0.004550.08055 S000000326MRPL36YBR122CverifiedMitochondrial ribosomal protein of the large subunit;overproduction suppresses mutations in the COX2leader peptide-encoding region 0.004540.08024 S000001593KTI12YKL110CverifiedProtein that plays a role, with Elongator complex, inmodification of wobble nucleosides in tRNA;involved in sensitivity to G1 arrest induced byzymocin; interacts with chromatin throughoutthe genome; also interacts with Cdc19p 0.004520.08004 S000000004SSA1YAL005CverifiedATPase involved in protein folding and nuclear localizationsignal (NLS)-directed nuclear transport; memberof heat shock protein 70 (HSP70) family; formsa chaperone complex with Ydj1p; localized tothe nucleus, cytoplasm, and cell wall 0.004520.08004 S000002338PCL9YDL179WverifiedCyclin, forms a functional kinase complex with Pho85pcyclin-dependent kinase (Cdk), expressed inlate M/early G1 phase, activated by Swi5p 0.004520.08004 S000001199LIN1YHR156CverifiedNon-essential component of U5 snRNP; nuclear protein;physically interacts with Irr1p of cohesincomplex; may link together proteins involved inchromosome segregation, mRNA splicing and DNAreplication 0.004520.08004&radic S000004635HOF1YMR032WverifiedBud neck-localized, SH3 domain-containing protein required forcytokinesis; regulates actomyosin ring dynamicsand septin localization; interacts with theformins, Bni1p and Bnr1p, and with Cyk3p,Vrp1p, and Bni5p 0.004510.07942&radic&radic S000006367TIF3YPR163CverifiedTranslation initiation factor eIF-4B, has RNA annealingactivity; contains an RNA recognition motif andbinds to single-stranded RNA 0.00450.07942&radic&radic S000006276NOT5YPR072WverifiedSubunit of the CCR4-NOT complex, which is a globaltranscriptional regulator with roles intranscription initiation and elongation and inmRNA degradation 0.004490.07942 S000005433THP1YOL072WverifiedNuclear pore-associated protein, forms a complex with Sac3pthat is involved in transcription and in mRNAexport from the nucleus; contains a PAM domainimplicated in protein-protein binding 0.004480.07894 S000004322CHS5YLR330WverifiedProtein involved in export from the Golgi to plasma membrane;involved in chitin biosynthesis through itsrole in Chs3p localization; interacts withArf1p, Bch1p, Fmp50p, Bud7p, and Chs6p 0.004480.07894 S000003797HUL4YJR036CverifiedProtein with similarity to hect domain E3 ubiquitin-proteinligases, not essential for viability 0.004470.07894 S000000873YER071CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.004480.07894&radic S000004362ARC18YLR370CverifiedSubunit of the ARP2/3 complex, which is required for themotility and integrity of cortical actinpatches 0.004450.0785 S000004750RPL13BYMR142CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl13Ap; not essential forviability; has similarity to rat L13 ribosomalprotein 0.004460.0785 S000003850GRR1YJR090CverifiedF-box protein component of the SCF ubiquitin-ligase complex,required for Cln1p and Cln2p degradation;involved in carbon catabolite repression,glucose-dependent divalent cation transport,high-affinity glucose transport, andmorphogenesis 0.004440.07839&radic&radic S000005944MET12YPL023CverifiedIsozyme of methylenetetrahydrofolate reductase, catalyzes thereduction of 5,10-methylenetetrahydrofolate to5-methyltetrahydrofolate in the methioninebiosynthesis pathway 0.004430.0782 S000001248SCH9YHR205WverifiedProtein kinase that regulates signal transduction activity andG1 progression, controls cAPK activity,required for nitrogen activation of the FGMpathway, involved in life span regulation,homologous to mammalian Akt/PKB 0.004410.07716 S000001352ICE2YIL090WverifiedIntegral ER membrane protein with type-III transmembranedomains; mutations cause defects in cortical ERmorphology in both the mother and daughtercells 0.00440.07716 S000000322TEF2YBR118WverifiedTranslational elongation factor EF-1 alpha; also encoded byTEF1; functions in the binding reaction ofaminoacyl-tRNA (AA-tRNA) to ribosomes 0.004410.07716 S000002797SAC7YDR389WverifiedGTPase activating protein (GAP) for Rho1p, involved insignaling to the actin cytoskeleton, nullmutations suppress tor2 mutations andtemperature sensitive mutations in actin;potential Cdc28p substrate 0.004390.07716 S000003973COF1YLL050CverifiedCofilin, promotes actin filament depolarization in apH-dependent manner; binds both actin monomersand filaments and severs filaments , thought tobe regulated by phosphorylation at SER4,ubiquitous and essential in eukaryotes 0.004390.07716 S000004521CMP2YML057WverifiedCalcineurin A; one isoform (the other is CNA1) of the catalyticsubunit of calcineurin, aCa++/calmodulin-regulated protein phosphatasewhich regulates Crz1p (a stress-responsetranscription factor), the other calcineurinsubunit is CNB1 0.004380.07716 S000004855RPL20AYMR242CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl20Bp and has similarity to ratL18a ribosomal protein 0.004370.07665 S000005009AQR1YNL065WverifiedPlasma membrane transporter of the major facilitatorsuperfamily that confers resistance toshort-chain monocarboxylic acids and quinidine 0.004360.07665 S000002393GYP7YDL234CverifiedGTPase-activating protein for yeast Rab family membersincluding: Ypt7p (most effective), Ypt1p,Ypt31p, and Ypt32p (in vitro); involved invesicle mediated protein trafficking 0.004360.07665 S000005679PDR5YOR153WverifiedShort-lived membrane ABC (ATP-binding cassette) transporter,actively exports various drugs, expressionregulated by Pdr1p; also involved in steroidtransport, cation resistance, and cellulardetoxification during exponential growth 0.004370.07665&radic S000004038RPS0BYLR048WverifiedProtein component of the small (40S) ribosomal subunit, nearlyidentical to Rps0Ap; required for maturation of18S rRNA along with Rps0Ap; deletion of eitherRPS0 gene reduces growth rate, deletion of bothgenes is lethal 0.004370.07665 S000003517ZUO1YGR285CverifiedCytosolic ribosome-associated chaperone that acts, togetherwith Ssz1p and the Ssb proteins, as a chaperonefor nascent polypeptide chains; contains a DnaJdomain and functions as a J-protein partner forSsb1p and Ssb2p 0.004370.07665&radic&radic S000000758MCM3YEL032WverifiedProtein involved in DNA replication; component of the Mcm2-7hexameric complex that binds chromatin as apart of the pre-replicative complex 0.004360.07665&radic S000000614MAK31YCR020C-AverifiedNon-catalytic subunit of N-terminal acetyltransferase of theNatC type; required for replication of dsRNAvirus; member of the Sm protein family 0.004350.07665 S000001494CCE1YKL011CverifiedMitochondrial cruciform cutting endonuclease, cleaves Hollidayjunctions formed during recombination ofmitochondrial DNA 0.004350.07638&radic&radic S000001365DPH1YIL103WverifiedProtein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p,for synthesis of diphthamide, which is amodified histidine residue of translationelongation factor 2 (Eft1p or Eft2p); may actin a complex with Dph2p and Kti11p 0.004330.07619 S000005820RRS1YOR294WverifiedEssential protein that binds ribosomal protein L11 and isrequired for nuclear export of the 60Spre-ribosomal subunit during ribosomebiogenesis; mouse homolog shows alteredexpression in Huntington's disease model mice 0.004330.07619 S000003824RPA12YJR063WverifiedRNA polymerase I subunit A12.2; contains two zinc bindingdomains, and the N terminal domain isresponsible for anchoring to the RNA pol Icomplex 0.004330.07619 S000002216USO1YDL058WverifiedEssential protein involved in intracellular protein transport,coiled-coil protein necessary for transportfrom ER to Golgi; required for assembly of theER-to-Golgi SNARE complex 0.004320.07597 S000000691OCA4YCR095CuncharacterizedCytoplasmic protein required for replication of Brome mosaicvirus in S. cerevisiae, which is a model systemfor studying replication of positive-strand RNAviruses in their natural hosts 0.004320.07597 S000005486MDH2YOL126CverifiedCytoplasmic malate dehydrogenase, one of the three isozymesthat catalyze interconversion of malate andoxaloacetate; involved in gluconeogenesisduring growth on ethanol or acetate as carbonsource; interacts with Pck1p and Fbp1p 0.004320.07597 S000002133PTC6YCR079WverifiedPhosphoprotein phosphatase type 2C; contains mitochondrialtargeting sequence; green fluorescent protein(GFP)-fusion protein localizes to themitochondrion; null mutant is sensitive torapamycin 0.004320.07597 S000004295ACO1YLR304CverifiedAconitase, required for the tricarboxylic acid (TCA) cycle andalso independently required for mitochondrialgenome maintenance; component of themitochondrial nucleoid; mutation leads toglutamate auxotrophy 0.004320.07597 S000002550SAN1YDR143CverifiedUbiquitin-protein ligase, involved in the proteasome-dependentdegradation of aberrant nuclear proteins; san1mutations suppress sir4, spt16, and cdc68mutations, suggesting a role in chromatinsilencing 0.004310.07597 S000003088PRP43YGL120CverifiedRNA helicase in the DEAH-box family, functions in both RNApolymerase I and polymerase II transcriptmetabolism, involved in release of thelariat-intron from the spliceosome 0.004310.07593 S000005662IDH2YOR136WverifiedSubunit of mitochondrial NAD(+)-dependent isocitratedehydrogenase, which catalyzes the oxidation ofisocitrate to alpha-ketoglutarate in the TCAcycle 0.004310.07593 S000004051RPL22AYLR061WverifiedProtein component of the large (60S) ribosomal subunit, hassimilarity to Rpl22Bp and to rat L22 ribosomalprotein 0.004310.0757 S000004479PSP2YML017WverifiedAsn rich cytoplasmic protein that contains RGG motifs;high-copy suppressor of group IIintron-splicing defects of a mutation in MRS2and of a conditional mutation in POL1 (DNApolymerase alpha); possible role inmitochondrial mRNA splicing 0.004290.0753 S000000036CDC19YAL038WverifiedPyruvate kinase, functions as a homotetramer in glycolysis toconvert phosphoenolpyruvate to pyruvate, theinput for aerobic (TCA cycle) or anaerobic(glucose fermentation) respiration 0.004290.0753 S000002622AHA1YDR214WverifiedCo-chaperone that binds to Hsp82p and activates its ATPaseactivity; similar to Hch1p; expression isregulated by stresses such as heat shock 0.004280.0753 S000001878MDJ1YFL016CverifiedProtein involved in folding of mitochondrially synthesizedproteins in the mitochondrial matrix; localizesto the mitochondrial inner membrane; member ofthe DnaJ family of molecular chaperones 0.00430.0753 S000003674TIF2YJL138CverifiedTranslation initiation factor eIF4A, identical to Tif1p;DEA(D/H)-box RNA helicase that couples ATPaseactivity to RNA binding and unwinding; forms adumbbell structure of two compact domainsconnected by a linker; interacts with eIF4G 0.004290.0753 S000001718TOF2YKR010CverifiedNonessential mitochondrial protein of unknown function withsequence similarity to Net1p; identified as atopoisomerase I (Top1p) binding protein;displays synthetic genetic interactions withTOP1 and HPR1 0.004260.07492 S000005514ZPS1YOL154WverifiedPutative GPI-anchored protein; transcription is induced underlow-zinc conditions, as mediated by the Zap1ptranscription factor, and at alkaline pH 0.004270.07492 S000004465GIS4YML006CverifiedCAAX box containing protein of unknown function, proposed to beinvolved in the RAS/cAMP signaling pathway 0.004260.07492 S000001537DEF1YKL054CverifiedRNAPII degradation factor, forms a complex with Rad26p inchromatin, enables ubiquitination andproteolysis of RNAPII present in an elongationcomplex 0.004270.07492&radic&radic S000004677IRC21YMR073CuncharacterizedPutative protein of unknown function; proposed to be involvedin resistance to carboplatin and cisplatin;shares similarity to a human cytochromeoxidoreductase; null mutant displays increasedlevels of spontaneous Rad52 foci 0.004260.07492 S000005441IRA2YOL081WverifiedGTPase-activating protein that negatively regulates RAS byconverting it from the GTP- to the GDP-boundinactive form, required for reducing cAMPlevels under nutrient limiting conditions, hassimilarity to Ira1p and human neurofibromin 0.004270.07492 S000003187MDM34YGL219CverifiedMitochondrial outer membrane protein, required for normalmitochondrial morphology and inheritance;localizes to dots on the mitochondrial surfacenear mtDNA nucleoids; interacts geneticallywith MDM31 and MDM32 0.004250.07465 S000000243ATP3YBR039WverifiedGamma subunit of the F1 sector of mitochondrial F1F0 ATPsynthase, which is a large, evolutionarilyconserved enzyme complex required for ATPsynthesis 0.004250.07465 S000002609SPC19YDR201WverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; also localized tonuclear side of spindle pole body 0.004250.07465 S000005364SIN3YOL004WverifiedComponent of the Sin3p-Rpd3p histone deacetylase complex,involved in transcriptional repression andactivation of diverse processes, includingmating-type switching and meiosis; involved inthe maintenance of chromosomal integrity 0.004250.07465 S000000814PRE1YER012Wverified20S proteasome beta-type subunit; localizes to the nucleusthroughout the cell cycle 0.004250.07465 S000006241ERV2YPR037CverifiedFlavin-linked sulfhydryl oxidase localized to the endoplasmicreticulum lumen, involved in disulfide bondformation within the ER 0.004240.07393 S000000780RPL12AYEL054CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl12Bp; rpl12a rpl12b doublemutant exhibits slow growth and slowtranslation; has similarity to E. coli L11 andrat L12 ribosomal proteins 0.004230.07393 S000003924DNM1YLL001WverifiedDynamin-related GTPase required for mitochondrial fission andthe maintenance of mitochondrial morphology,assembles on the cytoplasmic face ofmitochondrial tubules at sites at whichdivision will occur; also participates inendocytosis 0.004240.07393 S000004046ERG3YLR056WverifiedC-5 sterol desaturase, catalyzes the introduction of a C-5(6)double bond into episterol, a precursor inergosterol biosynthesis; mutants are viable,but cannot grow on non-fermentable carbonsources 0.004240.07393&radic&radic S000004918ADH2YMR303CverifiedGlucose-repressible alcohol dehydrogenase II, catalyzes theconversion of ethanol to acetaldehyde; involvedin the production of certain carboxylateesters; regulated by ADR1 0.004240.07393 S000003259RPS25AYGR027CverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps25Bp and has similarity to ratS25 ribosomal protein 0.004230.07393 S000002980ERG4YGL012WverifiedC-24(28) sterol reductase, catalyzes the final step inergosterol biosynthesis; mutants are viable,but lack ergosterol 0.00420.07371&radic&radic&radic S000004633YMR031CUncharacterizedPutative protein of unknown function with similarity to YKL050C and USO1/YDL058W; found in mitochondria; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR031C is not an essential gene 0.004210.07371 S000002213PSA1YDL055CverifiedGDP-mannose pyrophosphorylase (mannose-1-phosphateguanyltransferase), synthesizes GDP-mannosefrom GTP and mannose-1-phosphate in cell wallbiosynthesis; required for normal cell wallstructure 0.004210.07371 S000005589RPL3YOR063WverifiedProtein component of the large (60S) ribosomal subunit, hassimilarity to E. coli L3 and rat L3 ribosomalproteins; involved in the replication andmaintenance of killer double stranded RNA virus 0.004190.07346 S000001062YHR020WUncharacterizedPutative protein of unknown function, has similarity to proline-tRNA ligase; YHR020W is an essential gene 0.004190.0733 S000000846ERG28YER044CverifiedEndoplasmic reticulum membrane protein, may facilitateprotein-protein interactions between the Erg26pdehydrogenase and the Erg27p 3-ketoreductaseand/or tether these enzymes to the ER, alsointeracts with Erg6p 0.004190.0733&