Yfunc lets you browse current and predicted gene functions in yeast

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Prediction of GO:0007076 "mitotic chromosome condensation"

GO branch: BP
Number of currently annotated genes: 9

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest Lee:FKH2Harbison:FKH2_YPDIPR007673Huh:nucleusTAP:201Huh:nucleolusHo:S000005475PF06470Lee:MBP1TAP:125 S000004076SMC4YLR086WverifiedSubunit of the condensin complex, which reorganizes chromosomesduring cell division, forms a stable complexwith Smc2p that has ATP-hydrolyzing andDNA-binding activity and promotes knotting ofcircular DNA; potential Cdc28p substrate &radic0.155070.88495&radic&radic&radic S000001927SMC2YFR031CverifiedComponent of the condensin complex, essential SMC chromosomalATPase family member that forms a complex withSmc4p to form the active ATPase; Smc2p/Smc4pcomplex binds DNA, possibly in the cleft formedby the coiled-coil of the folded dimer &radic0.14050.85915&radic&radic S000001886SMC1YFL008WverifiedSubunit of the multiprotein cohesin complex, essential proteininvolved in chromosome segregation and indouble-strand DNA break repair; SMC chromosomalATPase family member, binds DNA with apreference for DNA with secondary structure 0.125280.80055&radic&radic&radic S000003610SMC3YJL074CverifiedSubunit of the multiprotein cohesin complex required for sisterchromatid cohesion in mitotic cells; alsorequired, with Rec8p, for cohesion andrecombination during meiosis; phylogeneticallyconserved SMC chromosomal ATPase family member 0.124350.80054&radic&radic&radic&radic S000002733YCG1YDR325WverifiedNon-SMC subunit of the condensin complex(Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required forestablishment and maintenance of chromosomecondensation, chromosome segregation and forchromatin binding of the condensin complex &radic0.102520.77338&radic&radic&radic&radic S000005243TRF5YNL299WverifiedPoly (A) polymerase involved in nuclear RNA quality controlbased on: homology with Trf4p, geneticinteractions with TRF4 mutants, physicalinteraction with Mtr4p (TRAMP subunit), and bydirect assay; disputed role as a sigma DNApolymerase 0.083110.71148&radic S000001288IRR1YIL026CverifiedSubunit of the cohesin complex, which is required for sisterchromatid cohesion during mitosis and meiosisand interacts with centromeres and chromosomearms, essential for viability 0.022780.47035&radic&radic&radic S000005194RAD50YNL250WverifiedSubunit of MRX complex, with Mre11p and Xrs2p, involved inprocessing double-strand DNA breaks invegetative cells, initiation of meiotic DSBs,telomere maintenance, and nonhomologous endjoining 0.019860.43592&radic S000004262YCS4YLR272CverifiedNon-SMC subunit of the condensin complex(Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required forestablishment and maintenance of chromosomecondensation, chromosome segregation, chromatinbinding of condensin and silencing at themating type locus &radic0.016110.40205&radic&radic&radic S000004375SMC6YLR383WverifiedProtein involved in structural maintenance of chromosomes;essential subunit of Mms21-Smc5-Smc6 complex;required for growth, DNA repair,interchromosomal and sister chromatidrecombination; homologous to S. pombe rad18 0.013980.37598&radic S000007230YCR018C-ADubiousPutative protein of unknown function; encoded opposite a Ty1 LTR 0.012970.3624&radic S000003084CDC20YGL116WverifiedCell-cycle regulated activator of anaphase-promotingcomplex/cyclosome (APC/C), which is requiredfor metaphase/anaphase transition; directsubiquitination of mitotic cyclins, Pds1p, andother anaphase inhibitors; potential Cdc28psubstrate 0.01150.35142&radic&radic&radic S000000449ISW1YBR245CverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPase thatforms a complex with Ioc2p and Ioc4p toregulate transcription elongation, and acomplex with Ioc3p to repress transcriptioninitiation 0.007450.29527&radic&radic S000005217TOF1YNL273WverifiedSubunit of a replication-pausing checkpoint complex(Tof1p-Mrc1p-Csm3p) that acts at the stalledreplication fork to promote sister chromatidcohesion after DNA damage, facilitating gaprepair of damaged DNA; interacts with the MCMhelicase 0.005220.23115&radic&radic S000001073RRM3YHR031CverifiedDNA helicase involved in rDNA replication and Ty1transposition; relieves replication fork pausesat telomeric regions; structurally andfunctionally related to Pif1p 0.00490.21742&radic&radic&radic S000002520PDS1YDR113CverifiedSecurin that inhibits anaphase by binding separin Esp1p, alsoblocks cyclin destruction and mitotic exit,essential for cell cycle arrest in mitosis inthe presence of DNA damage or aberrant mitoticspindles; also present in meiotic nuclei 0.004550.20357&radic&radic S000005176CSL4YNL232WverifiedSubunit of the exosome, which is an essential complex presentin both nucleus and cytoplasm that mediates RNAprocessing and degradation 0.004070.18128&radic&radic S000006211REC8YPR007CverifiedMeiosis-specific component of sister chromatid cohesioncomplex; maintains cohesion between sisterchromatids during meiosis I; maintains cohesionbetween centromeres of sister chromatids untilmeiosis II; homolog of S. pombe Rec8p 0.003840.17301 S000000100UTP20YBL004WverifiedComponent of the small-subunit (SSU) processome, which isinvolved in the biogenesis of the 18S rRNA 0.003690.16568&radic S000001710PAP1YKR002WverifiedPoly(A) polymerase, one of three factors required for mRNA3'-end polyadenylation, forms multiproteincomplex with polyadenylation factor I (PF I),also required for mRNA nuclear export; may alsopolyadenylate rRNAs 0.003480.15779&radic S000005032TOP2YNL088WverifiedEssential type II topoisomerase, relieves torsional strain inDNA by cleaving and re-sealing thephosphodiester backbone of both positively andnegatively supercoiled DNA; cleavescomplementary strands; localizes to axial coresin meiosis 0.003380.15468&radic S000000427TDP1YBR223CverifiedTyrosyl-DNA Phosphodiesterase I, hydrolyzes 3'-phosphotyrosylbonds to generate 3'-phosphate DNA andtyrosine, involved in the repair of DNA lesionscreated by topoisomerase I 0.003230.14878&radic S000001132YNG2YHR090CverifiedSubunit of the NuA4 histone acetyltransferase complex thatacetylates histone H4 and H2A; has similarityto the human tumor suppressor ING1 0.003160.14644&radic S000005394SMC5YOL034WverifiedStructural maintenance of chromosomes (SMC) protein; essentialsubunit of the Mms21-Smc5-Smc6 complex;required for growth and DNA repair; S. pombehomolog forms a heterodimer with S. pombeRad18p that is involved in DNA repair 0.003120.14548&radic S000005945RMI1YPL024WverifiedInvolved in response to DNA damage; null mutants have increasedrates of recombination and delayed S phase;interacts physically and genetically with Sgs1p(RecQ family member) and Top3p (topoisomeraseIII) 0.003040.14116&radic&radic S000003420BUB1YGR188CverifiedProtein kinase that forms a complex with Mad1p and Bub3p thatis crucial in the checkpoint mechanism requiredto prevent cell cycle progression into anaphasein the presence of spindle damage, associateswith centromere DNA via Skp1p 0.002960.13781&radic&radic S000005774YOR248WDubiousHypothetical protein 0.002880.13539&radic&radic&radic S000001341AIR1YIL079CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p to regulate methylationof Npl3p, which modulates Npl3p function inmRNA processing and export; has similarity toAir2p 0.002780.13036&radic S000000301VPS15YBR097WverifiedMyristoylated serine/threonine protein kinase involved invacuolar protein sorting; functions as amembrane-associated complex with Vps34p; activeform recruits Vps34p to the Golgi membrane;interacts with the GDP-bound form of Gpa1p 0.002770.13036 S000004681PDS5YMR076CverifiedProtein required for establishment and maintenance of sisterchromatid condensation and cohesion,colocalizes with cohesin on chromosomes in aninterdependent manner, may function as aprotein-protein interaction scaffold &radic0.002690.12745&radic&radic&radic&radic S000006003MOT1YPL082CverifiedEssential abundant protein involved in regulation oftranscription, removes Spt15p (TBP) from DNAvia its C-terminal ATPase activity, forms acomplex with TBP that binds TATA DNA with highaffinity but with altered specificity 0.002640.12478&radic&radic S000001596RAD27YKL113Cverified5' to 3' exonuclease, 5' flap endonuclease, required forOkazaki fragment processing and maturation aswell as for long-patch base-excision repair;member of the S. pombe RAD2/FEN1 family 0.002610.12266&radic&radic S000005475PAP2YOL115WverifiedCatalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), anuclear poly (A) polymerase complex involved inRNA quality control; catalyzes polyadenylationof unmodified tRNAs, and snoRNA and rRNAprecursors; disputed role as a DNA polymerase &radic0.002530.12095&radic&radic S000001718TOF2YKR010CverifiedNonessential mitochondrial protein of unknown function withsequence similarity to Net1p; identified as atopoisomerase I (Top1p) binding protein;displays synthetic genetic interactions withTOP1 and HPR1 0.002520.11984&radic S000003851JSN1YJR091CverifiedMember of the Puf family of RNA-binding proteins, interactswith mRNAs encoding membrane-associatedproteins; overexpression suppresses a tub2-150mutation and causes increased sensitivity tobenomyl in wild-type cells 0.002480.11822&radic&radic S000005943RAD1YPL022WverifiedSingle-stranded DNA endonuclease (with Rad10p), cleavessingle-stranded DNA during nucleotide excisionrepair and double-strand break repair; subunitof Nucleotide Excision Repair Factor 1 (NEF1);homolog of human XPF protein 0.002460.11754&radic S000002975YGL007WDubiousHypothetical protein 0.00240.11571&radic&radic S000001748YKR040CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W 0.00240.11571&radic&radic S000005114YNL170WDubiousHypothetical protein 0.00240.11571&radic&radic S000005206POL2YNL262WverifiedCatalytic subunit of DNA polymerase epsilon, one of the majorchromosomal DNA replication polymerasescharacterized by processivity and proofreadingexonuclease activity; also involved in DNAsynthesis during DNA repair 0.002330.11324&radic S000000193BRN1YBL097WverifiedEssential protein required for chromosome condensation, likelyto function as an intrinsic component of thecondensation machinery, may influence multipleaspects of chromosome transmission and dynamics &radic0.002320.1126&radic&radic&radic S000003391NSR1YGR159CverifiedNucleolar protein that binds nuclear localization sequences,required for pre-rRNA processing and ribosomebiogenesis 0.002330.1126&radic S000001293ULP2YIL031WverifiedPeptidase that deconjugates Smt3/SUMO-1 peptides from proteins,plays a role in chromosome cohesion atcentromeric regions and recovery fromcheckpoint arrest induced by DNA damage or DNAreplication defects; potential Cdc28p substrate 0.002330.1126 S000000631RRP43YCR035CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp41p, Rrp42p,Rrp4p and Dis3p; required for efficientmaturation of 5.8S, 18S and 25S rRNA 0.002290.1113&radic&radic S000003586MTR4YJL050WverifiedDead-box family ATP dependent helicase required for mRNA exportfrom the nucleus; co-factor of the exosomecomplex, required for 3' end formation of 5.8SrRNA 0.002250.10995&radic&radic S000003416UBR1YGR184CverifiedUbiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2pto ubiquitinate substrates of the N-end rulepathway; binds to the Rpn2p, Rpt1p, and Rpt6pproteins of the 19S particle of the 26Sproteasome 0.002240.10959&radic S000004035STU2YLR045CverifiedMicrotubule-associated protein (MAP) of the XMAP215/Dis1family; regulates microtubule dynamics duringspindle orientation and metaphase chromosomealignment; interacts with spindle pole bodycomponent Spc72p 0.00210.10258 S000004925PSE1YMR308CverifiedKaryopherin/importin that interacts with the nuclear porecomplex; acts as the nuclear import receptorfor specific proteins, including Pdr1p, Yap1p,Ste12p, and Aft1p 0.00210.10258&radic S000004846YMR233WUncharacterizedProtein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; YMR233W is not an essential gene 0.00210.10258&radic&radic S000002918SMT3YDR510WverifiedUbiquitin-like protein of the SUMO family, conjugated to lysineresidues of target proteins; regulateschromatid cohesion, chromosome segregation,APC-mediated proteolysis, DNA replication andseptin ring dynamics 0.002080.1024&radic S000006314RPC40YPR110CverifiedRNA polymerase subunit, common to RNA polymerase I and III 0.002060.10105&radic&radic S000004752YMR144WUncharacterizedPutative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene 0.002050.10084&radic&radic&radic&radic S000002732UTP4YDR324CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.001990.09797&radic&radic&radic S000001580YKL097CDubiousDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species 0.001950.09649&radic&radic S000002334AIR2YDL175CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p; may regulatemethylation of Npl3p, which modulates Npl3pfunction in mRNA processing and export; hassimilarity to Air1p 0.001910.09523&radic S000005381DIS3YOL021CverifiedNucleolar exosome component, involved in rRNA processing andRNA degradation, binds Gsp1p/Ran and enhancesthe GEF activity of Srm1p, implicated inmitotic control, homologous to the E. coliRNase R of the RNase II family 0.001860.09304&radic&radic&radic S000003645UTP10YJL109CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.001810.09036&radic S000005366TOP1YOL006CverifiedTopoisomerase I, nuclear enzyme that relieves torsional strainin DNA by cleaving and re-sealing thephosphodiester backbone; relaxes bothpositively and negatively supercoiled DNA;functions in replication, transcription, andrecombination &radic0.001760.08828&radic&radic S000003282YGR050CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data 0.001680.08391&radic&radic S000004392YLR400WDubiousHypothetical protein 0.001680.08391&radic&radic S000004121ACE2YLR131CverifiedTranscription factor that activates expression of earlyG1-specific genes, localizes to daughter cellnuclei after cytokinesis and delays G1progression in daughters, localization isregulated by phosphorylation; potential Cdc28psubstrate 0.001660.0835&radic&radic&radic S000001111RRP4YHR069CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp41p, Rrp42p,Rrp43p and Dis3p 0.001660.0835&radic&radic&radic S000000682CSM1YCR086WverifiedNucleolar protein that forms a complex with Lrs4p which bindsMam1p at kinetochores during meiosis I tomediate accurate chromosome segregation, may beinvolved in premeiotic DNA replication;possible role in telomere maintenance 0.001660.08329&radic S000006323CLB2YPR119WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the transition from G2 to Mphase; accumulates during G2 and M, thentargeted via a destruction box motif forubiquitin-mediated degradation by theproteasome 0.001630.08239&radic&radic&radic S000001066MAS2YHR024CverifiedLarger subunit of the mitochondrial processing protease (MPP),essential processing enzyme that cleaves theN-terminal targeting sequences frommitochondrially imported proteins 0.001610.08025&radic S000000612MAK32YCR019WverifiedProtein necessary for structural stability of L-Adouble-stranded RNA-containing particles 0.00160.08025 S000000072CDC15YAR019CverifiedProtein kinase of the Mitotic Exit Network that is localized tothe spindle pole bodies at late anaphase;promotes mitotic exit by directly switching onthe kinase activity of Dbf2p 0.001570.07857 S000004153MAS1YLR163CverifiedSmaller subunit of the mitochondrial processing protease (MPP),essential processing enzyme that cleaves theN-terminal targeting sequences frommitochondrially imported proteins 0.001550.07802&radic S000005842SFG1YOR315WverifiedNuclear protein, putative transcription factor required forgrowth of superficial pseudohyphae (which donot invade the agar substrate) but not forinvasive pseudohyphal growth; may act togetherwith Phd1p; potential Cdc28p substrate 0.001550.07802&radic&radic&radic S000002553SWI5YDR146CverifiedTranscription factor that activates transcription of genesexpressed at the M/G1 phase boundary and in G1phase; localization to the nucleus occursduring G1 and appears to be regulated byphosphorylation by Cdc28p kinase 0.001540.07762&radic&radic&radic S000001406TID3YIL144WverifiedComponent of the evolutionarily conservedkinetochore-associated Ndc80 complex(Ndc80p-Nuf2p-Spc24p-Spc25p); conservedcoiled-coil protein involved in chromosomesegregation, spindle checkpoint activity,kinetochore assembly and clustering 0.001520.07663 S000004517YML053CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YML053C is not an essential gene 0.001520.07646&radic&radic&radic S000002859YHP1YDR451CverifiedOne of two homeobox transcriptional repressors (see alsoYox1p), that bind to Mcm1p and to early cellcycle box (ECB) elements of cell cycleregulated genes, thereby restrictingECB-mediated transcription to the M/G1 interval 0.001470.07386&radic&radic&radic&radic S000003574IRC18YJL037WuncharacterizedPutative protein of unknown function; expression induced inrespiratory-deficient petite cells, incarbon-limited chemostat cultures, duringmeiosis, sporulation and after alpha factortreatment; similar to adjacent ORF, YJL038C;null mutant displays increased levels ofspontaneous Rad52 foci 0.001460.07361 S000004732STO1YMR125WverifiedLarge subunit of the nuclear mRNA cap-binding protein complex,interacts with Npl3p to carry nuclear poly(A)+mRNA to cytoplasm; also involved in nuclearmRNA degradation and telomere maintenance;orthologous to mammalian CBP80 0.001410.07152&radic S000001924CDC14YFR028CverifiedProtein phosphatase required for mitotic exit; located in thenucleolus until liberated by the FEAR andMitotic Exit Network in anaphase, enabling itto act on key substrates to effect a decreasein CDK/B-cyclin activity and mitotic exit 0.00140.0711&radic S000001554YKL071WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.00140.0711 S000005116APC1YNL172WverifiedLargest subunit of the Anaphase-Promoting Complex/Cyclosome(APC/C), which is a ubiquitin-protein ligaserequired for degradation of anaphaseinhibitors, including mitotic cyclins, duringthe metaphase/anaphase transition 0.001390.0706&radic&radic&radic S000001807BAS1YKR099WverifiedMyb-related transcription factor involved in regulating basaland induced expression of genes of the purineand histidine biosynthesis pathways 0.001380.07&radic S000000913SWI4YER111CverifiedDNA binding component of the SBF complex (Swi4p-Swi6p), atranscriptional activator that in concert withMBF (Mbp1-Swi6p) regulates late G1-specifictranscription of targets including cyclins andgenes required for DNA synthesis and repair 0.001360.06888&radic&radic S000004733DLT1YMR126CuncharacterizedProtein of unknown function, deletion causes sensitivity tothermal stress 0.001350.06773 S000003207CSE1YGL238WverifiedNuclear envelope protein that mediates the nuclear export ofimportin alpha (Srp1p), homolog of metazoan CASprotein, required for accurate chromosomesegregation 0.001330.06679&radic S000001806UBP11YKR098CverifiedUbiquitin-specific protease that cleaves ubiquitin fromubiquitinated proteins 0.001340.06679 S000002161MCD1YDL003WverifiedEssential protein required for sister chromatid cohesion inmitosis and meiosis; subunit of the cohesincomplex; expression is cell cycle regulated andpeaks in S phase &radic0.001320.06604&radic&radic&radic S000004872YMR259CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR259C is not an essential gene 0.001310.0659&radic S000006038IDI1YPL117CverifiedIsopentenyl diphosphate:dimethylallyl diphosphate isomerase(IPP isomerase), catalyzes an essentialactivation step in the isoprenoid biosyntheticpathway; required for viability 0.001310.06523&radic&radic&radic S000000305FES1YBR101CverifiedHsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog ofSil1p, which is the nucleotide exchange factorfor BiP (Kar2p) in the endoplasmic reticulum 0.001310.06523&radic S000002175CDC7YDL017WverifiedDDK (Dbf4-dependent kinase) catalytic subunit required forfiring origins and replication fork progressionin mitosis through phosphorylation of Mcm2-7pcomplexes and Cdc45p; kinase activitycorrelates with cyclical DBF4 expression 0.001290.06413&radic&radic&radic&radic S000001103GIC1YHR061CverifiedProtein of unknown function involved in initiation of buddingand cellular polarization, interacts withCdc42p via the Cdc42/Rac-interactive binding(CRIB) domain 0.001290.06413&radic&radic&radic&radic S000000339CKS1YBR135WverifiedSubunit of the Cdc28 protein kinase, required for mitoticproteolysis, may also be involved in theproteolysis of the G1 cyclins 0.001280.0632&radic&radic&radic S000004494RAD52YML032CverifiedProtein that stimulates strand exchange by facilitating Rad51pbinding to single-stranded DNA; annealscomplementary single-stranded DNA; involved inthe repair of double-strand breaks in DNAduring vegetative growth and meiosis 0.001270.06308&radic S000006379DPB2YPR175WverifiedSecond largest subunit of DNA polymerase II (DNA polymeraseepsilon), required for normal yeast chromosomalreplication; expression peaks at the G1/S phaseboundary; potential Cdc28p substrate 0.001240.06136&radic S000004886ZDS1YMR273CverifiedProtein that interacts with silencing proteins at the telomere,involved in transcriptional silencing; has arole in localization of Bcy1p, a regulatorysubunit of protein kinase A; implicated in mRNAnuclear export 0.001230.06123 S000000120NCL1YBL024WverifiedS-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase,methylates cytosine to m5C at several positionsin tRNAs and intron-containing pre-tRNAs;similar to Nop2p and human proliferationassociated nucleolar protein p120 0.001230.06046&radic S000004349RSC2YLR357WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; involvedin telomere maintenance 0.001220.06046&radic S000001295BCY1YIL033CverifiedRegulatory subunit of the cyclic AMP-dependent protein kinase(PKA), a component of a signaling pathway thatcontrols a variety of cellular processes,including metabolism, cell cycle, stressresponse, stationary phase, and sporulation 0.001210.05959&radic S000005056DBP2YNL112WverifiedEssential ATP-dependent RNA helicase of the DEAD-box proteinfamily, involved in nonsense-mediated mRNAdecay and rRNA processing 0.00120.05899&radic S000003567MAD2YJL030WverifiedComponent of the spindle-assembly checkpoint complex, whichdelays the onset of anaphase in cells withdefects in mitotic spindle assembly; forms acomplex with Mad1p 0.001190.05836&radic S000005552BUB3YOR026WverifiedKinetochore checkpoint WD40 repeat protein that localizes tokinetochores during prophase and metaphase,delays anaphase in the presence of unattachedkinetochores; forms complexes with Mad1p-Bub1pand with Cdc20p, binds Mad2p and Mad3p 0.001130.05512&radic S000005599SGO1YOR073WverifiedComponent of the spindle checkpoint, involved in sensing lackof tension on mitotic chromosomes; protectscentromeric Rec8p at meiosis I; required foraccurate chromosomal segregation at meiosis IIand for mitotic chromosome stability 0.001140.05512&radic&radic S000005887PDE2YOR360CverifiedHigh-affinity cyclic AMP phosphodiesterase, component of thecAMP-dependent protein kinase signaling system,protects the cell from extracellular cAMP,contains readthrough motif surroundingtermination codon 0.001120.05428&radic S000003861YJR100CUncharacterizedPutative protein of unknown function; appears related to murine NOR1, which is highly expressed in leukemogenic cell lines 0.001120.05428 S000000129RIB1YBL033CverifiedGTP cyclohydrolase II; catalyzes the first step of theriboflavin biosynthesis pathway 0.001110.05371&radic&radic&radic S000000881YER079WUncharacterizedHypothetical protein 0.00110.05326&radic&radic&radic&radic S000001195SPO12YHR152WverifiedNucleolar protein of unknown function, positive regulator ofexit from mitosis; involved in regulating therelease of Cdc14p from the nucleolus in earlyanaphase; proposed to play similar role inmeiosis 0.00110.05299&radic&radic&radic&radic S000004577ZDS2YML109WverifiedProtein that interacts with silencing proteins at the telomere,involved in transcriptional silencing; paralogof Zds1p 0.001090.05245 S000002360TRM8YDL201WverifiedSubunit of a tRNA methyltransferase complex composed of Trm8pand Trm82p that catalyzes 7-methylguanosinemodification of tRNA 0.001080.05196&radic S000001873GAT1YFL021WverifiedTranscriptional activator of genes involved in nitrogencatabolite repression, member of the GATAfamily of DNA binding proteins; activity andlocalization regulated by nitrogen limitationand Ure2p 0.001070.05053&radic&radic&radic S000004812CLN1YMR199WverifiedG1 cyclin involved in regulation of the cell cycle; activatesCdc28p kinase to promote the G1 to S phasetransition; late G1 specific expression dependson transcription factor complexes, MBF(Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) 0.001070.05053&radic&radic&radic&radic S000004391BDF1YLR399CverifiedProtein involved in transcription initiation at TATA-containingpromoters; associates with the basaltranscription factor TFIID; contains twobromodomains; corresponds to the C-terminalregion of mammalian TAF1; redundant with Bdf2p 0.001060.05053&radic&radic&radic S000003888RSF2YJR127CverifiedZinc-finger protein involved in transcriptional control of bothnuclear and mitochondrial genes, many of whichspecify products required for glycerol-basedgrowth, respiration, and other functions 0.001070.05053&radic&radic&radic S000000277RDH54YBR073WverifiedDNA-dependent ATPase, stimulates strand exchange by modifyingthe topology of double-stranded DNA; involvedin the recombinational repair of double-strandbreaks in DNA during mitosis and meiosis;proposed to be involved in crossoverinterference 0.001020.04869&radic S000003998PAM18YLR008CverifiedConstituent of the mitochondrial import motor associated withthe presequence translocase, along with Ssc1p,Tim44p, Mge1p, and Pam16p; stimulates theATPase activity of Ssc1p to drive mitochondrialimport; contains a J domain 0.001010.04843 S000002581HMO1YDR174WverifiedChromatin associated high mobility group (HMG) family memberinvolved in genome maintenance; rDNA-bindingcomponent of the Pol I transcription system;associates with a 5'-3' DNA helicase and Fpr1p,a prolyl isomerase 0.0010.04616&radic S000000897RAD51YER095WverifiedStrand exchange protein, forms a helical filament with DNA thatsearches for homology; involved in therecombinational repair of double-strand breaksin DNA during vegetative growth and meiosis;homolog of Dmc1p and bacterial RecA protein 0.000990.045&radic&radic&radic S000003141KEM1YGL173CverifiedEvolutionarily-conserved 5'-3' exonuclease component ofcytoplasmic processing (P) bodies involved inmRNA decay; plays a role inmicrotubule-mediated processes, filamentousgrowth, ribosomal RNA maturation, and telomeremaintenance 0.000960.04318 S000004901HSH155YMR288WverifiedU2-snRNP associated splicing factor that forms extensiveassociations with the branch site-3' splicesite-3' exon region upon prespliceosomeformation; similarity to the mammalian U2snRNP-associated splicing factor SAP155 0.000960.04318&radic S000004959HEF3YNL014WverifiedTranslational elongation factor EF-3; paralog of YEF3 andmember of the ABC superfamily; stimulates EF-1alpha-dependent binding of aminoacyl-tRNA bythe ribosome; normally expressed in zincdeficient cells 0.000920.04181 S000000050ACS1YAL054CverifiedAcetyl-coA synthetase isoform which, along with Acs2p, is thenuclear source of acetyl-coA for histoneacetlyation; expressed during growth onnonfermentable carbon sources and under aerobicconditions 0.000920.04181&radic S000002563RPA14YDR156WverifiedRNA polymerase I subunit A14 0.000920.04156&radic S000003575YJL038CUncharacterizedPutative protein of unknown function; expression induced during sporulation and repressed during vegetative growth by Sum1p and Hst1p; similar to adjacent open reading frame, YJL037W 0.00090.04097 S000004683CTF18YMR078CverifiedSubunit of a complex with Ctf8p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion; may have overlappingfunctions with Rad24p in the DNA damagereplication checkpoint 0.000890.04039&radic S000000214HHT1YBR010WverifiedOne of two identical histone H3 proteins (see also HHT2); corehistone required for chromatin assembly,involved in heterochromatin-mediated telomericand HM silencing; regulated by acetylation,methylation, and mitotic phosphorylation 0.000880.04006&radic&radic S000006060UME1YPL139CverifiedNegative regulator of meiosis, required for repression of asubset of meiotic genes during vegetativegrowth, binding of histone deacetylase Rpd3prequired for activity, contains a NEE box and aWD repeat motif; homologous with Wtm1p, Wtm2p 0.000880.03994&radic&radic S000000912KAP123YER110CverifiedKaryopherin beta, mediates nuclear import of ribosomal proteinsprior to assembly into ribosomes and import ofhistones H3 and H4; localizes to the nuclearpore, nucleus, and cytoplasm; exhibits geneticinteractions with RAI1 0.000870.03994&radic&radic S000004390SKI2YLR398CverifiedPutative RNA helicase, involved in exosome mediated 3' to 5'mRNA degradation and translation inhibition ofnon-poly(A) mRNAs; forms complex with Ski3p andSki8p; required for repressing propagation ofdsRNA viruses 0.000850.03923 S000004837MRE11YMR224CverifiedSubunit of a complex with Rad50p and Xrs2p (RMX complex) thatfunctions in repair of DNA double-strand breaksand in telomere stability, exhibits nucleaseactivity that appears to be required for RMXfunction; widely conserved 0.000850.03923&radic S000000566MRC1YCL061CverifiedS-phase checkpoint protein found at replication forks, requiredfor DNA replication; also required for Rad53pactivation during DNA replication stress, whereit forms a replication-pausing complex withTof1p and is phosphorylated by Mec1p; proteininvolved in replication checkpoint 0.000850.03923&radic S000006434LSM3YLR438C-AverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.000850.03893&radic&radic&radic S000004049REX2YLR059CverifiedRNA exonuclease, required for U4 snRNA maturation; functionsredundantly with Rnh70p in 5.8S rRNAmaturation, and with Rnh70p and Rex3p inprocessing of U5 snRNA and RNase P RNA; memberof RNase D family of exonucleases 0.000830.0381&radic&radic S000002904PUF6YDR496CverifiedPumilio-homology domain protein that binds ASH1 mRNA at PUFconsensus sequences in the 3' UTR and repressesits translation, resulting in proper asymmetriclocalization of ASH1 mRNA 0.000840.0381&radic&radic S000004172SWI6YLR182WverifiedTranscription cofactor, forms complexes with DNA-bindingproteins Swi4p and Mbp1p to regulatetranscription at the G1/S transition; involvedin meiotic gene expression; localizationregulated by phosphorylation; potential Cdc28psubstrate 0.000830.0381&radic S000000213HHF1YBR009CverifiedOne of two identical histone H4 proteins (see also HHF2); corehistone required for chromatin assembly andchromosome function; contributes to telomericsilencing; N-terminal domain involved inmaintaining genomic integrity 0.000830.0381&radic&radic S000002160NHP10YDL002CverifiedProtein related to mammalian high mobility group proteins;likely component of the INO80 complex, which isan ATP-dependent chromatin-remodeling complex 0.000840.0381&radic S000003130SUT1YGL162WverifiedTranscription factor of the Zn[II]2Cys6 family involved insterol uptake; involved in induction of hypoxicgene expression 0.000830.038&radic S000002222UBC9YDL064WverifiedSUMO-conjugating enzyme involved in the Smt3p conjugationpathway; nuclear protein required for S- andM-phase cyclin degradation and mitotic control;involved in proteolysis mediated by theanaphase-promoting complex cyclosome (APCC) 0.000810.03719&radic S000000221KAP104YBR017CverifiedTransportin, cytosolic karyopherin beta 2 involved in deliveryof heterogeneous nuclear ribonucleoproteins tothe nucleoplasm, binds rg-nuclear localizationsignals on Nab2p and Hrp1p, plays a role incell-cycle progression 0.000810.03719&radic S000006250MCM16YPR046WverifiedProtein involved in kinetochore-microtubule mediated chromosomesegregation; binds to centromere DNA 0.000810.03719&radic S000001608RRN3YKL125WverifiedProtein required for transcription of rDNA by RNA polymerase I;transcription factor independent of DNAtemplate; involved in recruitment of RNApolymerase I to rDNA 0.000820.03719&radic&radic&radic S000005831ISW2YOR304WverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPasecomponent that, with Itc1p, forms a complexrequired for repression of a-specific genes,INO1, and early meiotic genes during mitoticgrowth 0.000810.03708&radic S000004291EXG1YLR300WverifiedMajor exo-1,3-beta-glucanase of the cell wall, involved in cellwall beta-glucan assembly; exists as threedifferentially glycosylated isoenzymes 0.00080.03708&radic&radic&radic S000003088PRP43YGL120CverifiedRNA helicase in the DEAH-box family, functions in both RNApolymerase I and polymerase II transcriptmetabolism, involved in release of thelariat-intron from the spliceosome 0.00080.03696&radic S000002840NPL3YDR432WverifiedRNA-binding protein that carries poly(A)+ mRNA from the nucleusinto the cytoplasm; phosphorylation by Sky1p inthe cytoplasm may promote release of mRNAs 0.00080.03696&radic S000002908RPL37BYDR500CverifiedProtein component of the large (60S) ribosomal subunit, hassimilarity to Rpl37Ap and to rat L37 ribosomalprotein 0.000790.03639&radic&radic&radic S000005372HTZ1YOL012CverifiedHistone variant H2AZ, exchanged for histone H2A in nucleosomesby the SWR1 complex; involved intranscriptional regulation through preventionof the spread of silent heterochromatin 0.000790.03639&radic S000005772YOR246CUncharacterizedProtein with similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts 0.000790.03639&radic&radic&radic S000001392ASG1YIL130WuncharacterizedProposed transcriptional activator, member of the Gal4p familyof zinc cluster proteins 0.000790.03577&radic S000001393FKH1YIL131CverifiedForkhead family transcription factor with a minor role in theexpression of G2/M phase genes; negativelyregulates transcriptional elongation; positiverole in chromatin silencing at HML and HMR;regulates donor preference during switching 0.000780.03577&radic S000002440MRH1YDR033WverifiedProtein that localizes primarily to the plasma membrane, alsofound at the nuclear envelope; has similarityto Hsp30p and Yro2p, which are induced duringheat shock 0.000780.03577&radic&radic S000000521DCC1YCL016CverifiedSubunit of a complex with Ctf8p and Ctf18p that shares somecomponents with Replication Factor C, requiredfor sister chromatid cohesion and telomerelength maintenance 0.000770.03577&radic S000004180MMR1YLR190WverifiedPhosphorylated protein of the mitochondrial outer membrane,localizes only to mitochondria of the bud;interacts with Myo2p to mediate mitochondrialdistribution to buds; mRNA is targeted to thebud via the transport system involving She2p 0.000770.03565&radic&radic S000001234CTF8YHR191CverifiedSubunit of a complex with Ctf18p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion 0.000760.03536 S000002976PMA1YGL008CverifiedPlasma membrane H+-ATPase, pumps protons out of the cell; majorregulator of cytoplasmic pH and plasma membranepotential; part of the P2 subgroup ofcation-transporting ATPases 0.000770.03536&radic&radic S000002847LRS4YDR439WverifiedProtein involved in rDNA silencing; positively chargedcoiled-coil protein with limited similarity tomyosin 0.000760.03515&radic S000000282ECM33YBR078WverifiedGPI-anchored protein of unknown function, has a possible rolein apical bud growth; GPI-anchoring on theplasma membrane crucial to function; similar toSps2p and Pst1p 0.000760.03515&radic&radic&radic S000001186DSE2YHR143WverifiedDaughter cell-specific secreted protein with similarity toglucanases, degrades cell wall from thedaughter side causing daughter to separate frommother; expression is repressed by cAMP 0.000760.03507&radic&radic S000001686TOR2YKL203CverifiedPIK-related protein kinase and rapamycin target; subunit ofTORC1, a complex that regulates growth inresponse to nutrients and TORC2, a complex thatregulates cell-cycle dependent polarization ofthe actin cytoskeleton; involved in meiosis 0.000760.03507 S000003306SMD1YGR074WverifiedCore Sm protein Sm D1; part of heteroheptameric complex (withSmb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D1 0.000760.03503&radic S000001885CDC4YFL009WverifiedF-box protein required for G1/S and G2/M transition, associateswith Skp1p and Cdc53p to form a complex,SCFCdc4, which acts as ubiquitin-protein ligasedirecting ubiquitination of the phosphorylatedCDK inhibitor Sic1p 0.000750.03483 S000004711PGM2YMR105CverifiedPhosphoglucomutase, catalyzes the conversion fromglucose-1-phosphate to glucose-6-phosphate,which is a key step in hexose metabolism;functions as the acceptor for aGlc-phosphotransferase 0.000750.03483&radic&radic S000005051YAF9YNL107WverifiedSubunit of both the NuA4 histone H4 acetyltransferase complexand the SWR1 complex, may function toantagonize silencing near telomeres; interactsdirectly with Swc4p, has homology to humanleukemogenic protein AF9, contains a YEATSdomain 0.000750.03483&radic S000001194YHR151CUncharacterizedPutative protein of unknown function 0.000750.03483&radic&radic&radic S000002671DIN7YDR263CverifiedMitochondrial nuclease functioning in DNA repair andreplication, modulates the stability of themitochondrial genome, induced by exposure tomutagens, also induced during meiosis at a timenearly coincident with commitment torecombination 0.000740.03454&radic&radic&radic S000002628YDR220CDubiousHypothetical protein 0.000750.03454 S000006399YPR195CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data 0.000750.03454 S000000093YAR070CDubiousHypothetical protein 0.000750.03454 S000000620YCR025CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene 0.000750.03454 S000000872RNR1YER070WverifiedRibonucleotide-diphosphate reductase (RNR), large subunit; theRNR complex catalyzes the rate-limiting step indNTP synthesis and is regulated by DNAreplication and DNA damage checkpoint pathwaysvia localization of the small subunits 0.000750.03454&radic&radic&radic S000002588SCC2YDR180WverifiedSubunit of cohesin loading factor (Scc2p-Scc4p), a complexrequired for the loading of cohesin complexesonto chromosomes; involved in establishingsister chromatid cohesion during DSB repair viahistone H2AX 0.000740.03444&radic S000001016RIM4YHL024WverifiedPutative RNA-binding protein required for the expression ofearly and middle sporulation genes 0.000740.03431&radic&radic S000003651ASF1YJL115WverifiedNucleosome assembly factor, involved in chromatin assembly anddisassembly, anti-silencing protein that causesderepression of silent loci when overexpressed 0.000740.03431&radic S000000241SCO1YBR037CverifiedCopper-binding protein of the mitochondrial inner membrane,required for cytochrome c oxidase activity andrespiration; may function to deliver copper tocytochrome c oxidase; has similarity tothioredoxins 0.000730.03409&radic&radic S000000453ARO4YBR249Cverified3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase,catalyzes the first step in aromatic amino acidbiosynthesis and is feedback-inhibited bytyrosine or high concentrations ofphenylalanine or tryptophan 0.000720.03347&radic S000006305SNT309YPR101WverifiedComponent of NineTeen complex (NTC) containing Prp19p involvedin mRNA splicing, interacts physically andgenetically with Prp19p 0.000720.03347&radic S000005559EXO1YOR033Cverified5'-3' exonuclease and flap-endonuclease involved inrecombination, double-strand break repair andDNA mismatch repair; member of the Rad2pnuclease family, with conserved N and Inuclease domains 0.000730.03347&radic S000002554EKI1YDR147WverifiedEthanolamine kinase, primarily responsible forphosphatidylethanolamine synthesis via theCDP-ethanolamine pathway; also exhibits cholinekinase activity 0.000720.03347&radic&radic S000002720SSF2YDR312WverifiedProtein required for ribosomal large subunit maturation,functionally redundant with Ssf1p; member ofthe Brix family 0.000730.03347&radic&radic&radic S000004179ATG26YLR189CverifiedUDP-glucose:sterol glucosyltransferase, conserved enzymeinvolved in synthesis of sterol glucosidemembrane lipids, involved in autophagy 0.000720.03347&radic&radic S000004811CIK1YMR198WverifiedKinesin-associated protein required for both karyogamy andmitotic spindle organization, interacts stablyand specifically with Kar3p and may function totarget this kinesin to a specific cellularrole; has similarity to Vik1p 0.000720.03347&radic&radic S000003367PRE9YGR135Wverified20S proteasome beta-type subunit; the only nonessential 20Ssubunit 0.000720.03347&radic S000003587IRC8YJL051WuncharacterizedBud tip localized protein of unknown function; mRNA is targetedto the bud by a She2p dependent transportsystem; mRNA is cell cycle regulated via Fkh2p,peaking in G2/M phase; null mutant displaysincreased levels of spontaneous Rad52 foci 0.000710.03347&radic&radic S000000281SLM4YBR077CverifiedComponent of the EGO complex, which is involved in theregulation of microautophagy, and of the GSEcomplex, which is required for proper sortingof amino acid permease Gap1p; gene exhibitssynthetic genetic interaction with MSS4 0.000720.03347&radic&radic&radic S000005638CEX1YOR112WverifiedCytoplasmic component of the nuclear aminoacylation-dependenttRNA export pathway; interacts with nuclearpore component Nup116p; copurifies with tRNAexport receptors Los1p and Msn5p, as well aseIF-1a and the RAN GTPase Gsp1p 0.000710.03329 S000003410PBP1YGR178CverifiedProtein interacting with poly(A)-binding protein Pab1p; likelyinvolved in controlling the extent of mRNApolyadenylation; forms a complex with Mkt1pthat may regulate HO translation; interactswith Lsm12p in a copurification assay 0.000710.03329&radic S000006037HOS3YPL116WverifiedTrichostatin A-insensitive homodimeric histone deacetylase(HDAC) with specificity in vitro for histonesH3, H4, H2A, and H2B; similar to Hda1p, Rpd3p,Hos1p, and Hos2p; deletion results in increasedhistone acetylation at rDNA repeats 0.000710.03323&radic&radic S000001390MET18YIL128WverifiedDNA repair and TFIIH regulator, required for both nucleotideexcision repair (NER) and RNA polymerase II(RNAP II) transcription; involved in telomeremaintenance 0.000710.03323 S000006132NIP7YPL211WverifiedNucleolar protein required for 60S ribosome subunit biogenesis,constituent of 66S pre-ribosomal particles;physically interacts with Nop8p and the exosomesubunit Rrp43p 0.000710.03323&radic&radic S000006353NCE102YPR149WverifiedProtein of unknown function; contains transmembrane domains;involved in secretion of proteins that lackclassical secretory signal sequences; componentof the detergent-insoluble glycolipid-enrichedcomplexes (DIGs) 0.000710.03291&radic&radic S000000128HEK2YBL032WverifiedRNA binding protein with similarity to hnRNP-K that localizesto the cytoplasm and to subtelomeric DNA;required for the proper localization of ASH1mRNA; involved in the regulation of telomereposition effect and telomere length 0.00070.03258&radic&radic S000005876CIN1YOR349WverifiedTubulin folding factor D involved in beta-tubulin (Tub2p)folding; isolated as mutant with increasedchromosome loss and sensitivity to benomyl 0.00070.03258 S000006076KIP2YPL155CverifiedKinesin-related motor protein involved in mitotic spindlepositioning, stabilizes microtubules bytargeting Bik1p to the plus end; Kip2p levelsare controlled during the cell cycle 0.000690.03226&radic&radic S000002860PPN1YDR452WverifiedVacuolar endopolyphosphatase with a role in phosphatemetabolism; functions as a homodimer 0.000690.03226&radic&radic&radic S000003827TOR1YJR066WverifiedPIK-related protein kinase and rapamycin target; subunit ofTORC1, a complex that controls growth inresponse to nutrients by regulatingtranslation, transcription, ribosomebiogenesis, nutrient transport and autophagy;involved in meiosis 0.00070.03226 S000004516SUR7YML052WverifiedPutative integral membrane protein; component of eisosomes;associated with endocytosis, along with Pil1pand Lsp1p; sporulation and plasma membranesphingolipid content are altered in mutants 0.00070.03226&radic&radic S000000337HSL7YBR133CverifiedProtein arginine N-methyltransferase that exhibits septin andHsl1p-dependent bud neck localization andperiodic Hsl1p-dependent phosphorylation;required along with Hsl1p for bud neckrecruitment, phosphorylation, and degradationof Swe1p 0.000690.03226&radic&radic S000000342YBR138CUncharacterizedCytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene 0.000690.03226&radic&radic S000000026FRT2YAL028WverifiedTail-anchored endoplasmic reticulum membrane protein, interactswith homolog Frt1p but is not a substrate ofcalcineurin (unlike Frt1p), promotes growth inconditions of high Na+, alkaline pH, or cellwall stress; potential Cdc28p substrate 0.000690.03226&radic&radic S000001141TRA1YHR099WverifiedSubunit of SAGA and NuA4 histone acetyltransferase complexes;interacts with acidic activators (e.g., Gal4p)which leads to transcription activation;similar to human TRRAP, which is a cofactor forc-Myc mediated oncogenic transformation 0.000690.03226 S000003324DBF2YGR092WverifiedSer/Thr kinase involved in transcription and stress response;functions as part of a network of genes in exitfrom mitosis; localization is cell cycleregulated; activated by Cdc15p during the exitfrom mitosis 0.000690.03226&radic&radic S000002259DUN1YDL101CverifiedCell-cycle checkpoint serine-threonine kinase required for DNAdamage-induced transcription of certain targetgenes, phosphorylation of Rad55p and Sml1p, andtransient G2/M arrest after DNA damage; alsoregulates postreplicative DNA repair 0.000680.03214&radic&radic S000000435SWC5YBR231CuncharacterizedProtein of unknown function, component of the SWR1 complex,which exchanges histone variant H2AZ (Htz1p)for chromatin-bound histone H2A 0.000680.03203&radic S000001956CWP2YKL096W-AverifiedCovalently linked cell wall mannoprotein, major constituent ofthe cell wall; plays a role in stabilizing thecell wall; involved in low pH resistance;precursor is GPI-anchored 0.000680.03203&radic&radic S000006111NAB3YPL190CverifiedSingle stranded DNA binding protein; acidic ribonucleoprotein;required for termination of non-poly(A)transcripts and efficient splicing; interactswith Nrd1p 0.000680.03188&radic S000004810VTI1YMR197CverifiedProtein involved in cis-Golgi membrane traffic; v-SNARE thatinteracts with two t-SNARES, Sed5p and Pep12p;required for multiple vacuolar sorting pathways 0.000680.03188&radic&radic S000000564KRR1YCL059CverifiedEssential nucleolar protein required for the synthesis of 18SrRNA and for the assembly of 40S ribosomalsubunit 0.000680.03188&radic&radic S000000242CHS2YBR038WverifiedChitin synthase II, requires activation from zymogenic form inorder to catalyze the transfer ofN-acetylglucosamine (GlcNAc) to chitin;required for the synthesis of chitin in theprimary septum during cytokinesis 0.000680.03181&radic&radic S000006256NHP6AYPR052CverifiedHigh-mobility group non-histone chromatin protein, functionallyredundant with Nhp6Bp; homologous to mammalianhigh mobility group proteins 1 and 2; acts torecruit transcription factor Rcs1p to certainpromoters 0.000670.03156&radic&radic S000004984BDP1YNL039WverifiedEssential subunit of RNA polymerase III transcription factor(TFIIIB), which is involved in transcription ofgenes encoding tRNAs, 5S rRNA, U6 snRNA, andother small RNAs 0.000670.03156&radic S000005873REV1YOR346WverifiedDeoxycytidyl transferase, forms a complex with the subunits ofDNA polymerase zeta, Rev3p and Rev7p; involvedin repair of abasic sites in damaged DNA 0.000670.03156&radic&radic S000005117MDG1YNL173CverifiedPlasma membrane protein involved in G-protein mediatedpheromone signaling pathway; overproductionsuppresses bem1 mutations 0.000670.03156&radic&radic S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.000670.03156&radic S000003547NOP9YJL010CuncharacterizedEssential nucleolar protein required for 18S rRNA synthesis 0.000670.03145&radic&radic S000003694CIS3YJL158CverifiedMannose-containing glycoprotein constituent of the cell wall;member of the PIR (proteins with internalrepeats) family 0.000670.03145&radic&radic S000000098HTB2YBL002WverifiedOne of two nearly identical (see HTB1) histone H2B subtypesrequired for chromatin assembly and chromosomefunction; Rad6p-Bre1p-Lge1p mediatedubiquitination regulates transcriptionalactivation, meiotic DSB formation and H3methylation 0.000660.03128&radic S000000364CDC28YBR160WverifiedCatalytic subunit of the main cell cycle cyclin-dependentkinase (CDK); alternately associates with G1cyclins (CLNs) and G2/M cyclins (CLBs) whichdirect the CDK to specific substrates 0.000660.03128&radic S000000027MYO4YAL029CverifiedOne of two type V myosin motors (along with MYO2) involved inactin-based transport of cargos; required formRNA transport, including ASH1 mRNA, andfacilitating the growth and movement of ERtubules into the growing bud along with She3p 0.000660.03128&radic&radic S000000949SCC4YER147CverifiedSubunit of cohesin loading factor (Scc2p-Scc4p), a complexrequired for the loading of cohesin complexesonto chromosomes; involved in establishingsister chromatid cohesion during double-strandbreak repair via phosphorylated histone H2AX 0.000660.03124&radic&radic S000004365VID22YLR373CverifiedGlycosylated integral membrane protein localized to the plasmamembrane; plays a role infructose-1,6-bisphosphatase (FBPase)degradation; involved in FBPase transport fromthe cytosol to Vid (vacuole import anddegradation) vesicles 0.000660.03124&radic S000004723SPC24YMR117CverifiedComponent of the evolutionarily conservedkinetochore-associated Ndc80 complex(Ndc80p-Nuf2p-Spc24p-Spc25p); involved inchromosome segregation, spindle checkpointactivity and kinetochore clustering 0.000660.03124&radic&radic S000003225ADH4YGL256WverifiedAlcohol dehydrogenase type IV, dimeric enzyme demonstrated tobe zinc-dependent despite sequence similarityto iron-activated alcohol dehydrogenases;transcription is induced in response to zincdeficiency; alcohol dehydrogenase isoenzyme IV 0.000660.03109&radic&radic S000004828GAS3YMR215WverifiedPutative 1,3-beta-glucanosyltransferase, has similarity toGas1p; localizes to the cell wall 0.000660.03109&radic&radic&radic S000003870CPA2YJR109CverifiedLarge subunit of carbamoyl phosphate synthetase, whichcatalyzes a step in the synthesis ofcitrulline, an arginine precursor 0.000650.03098&radic&radic S000002176ERP3YDL018CverifiedProtein with similarity to Emp24p and Erv25p, member of the p24family involved in ER to Golgi transport 0.000650.03097&radic&radic&radic S000000880YER078CUncharacterizedMetallopeptidase, localized to the mitochondrial matrix 0.000650.03086&radic&radic&radic S000003226MNT2YGL257CverifiedMannosyltransferase involved in adding the 4th and 5th mannoseresidues of O-linked glycans 0.000650.03074&radic&radic S000004470SPT5YML010WverifiedProtein that forms a complex with Spt4p and mediates bothactivation and inhibition of transcriptionelongation; Spt4p-Spt5p complex also plays arole in pre-mRNA processing 0.000650.03074&radic S000000362AMN1YBR158WverifiedProtein required for daughter cell separation, multiple mitoticcheckpoints, and chromosome stability; contains12 degenerate leucine-rich repeat motifs;expression is induced by the Mitotic ExitNetwork (MEN) 0.000640.03043&radic S000006239GLN1YPR035WverifiedGlutamine synthetase (GS), synthesizes glutamine from glutamateand ammonia; with Glt1p, forms the secondarypathway for glutamate biosynthesis fromammonia; expression regulated by nitrogensource and by amino acid limitation 0.000640.03043&radic&radic S000002789YRA1YDR381WverifiedNuclear protein that binds to RNA and to Mex67p, required forexport of poly(A)+ mRNA from the nucleus;member of the REF (RNA and export factorbinding proteins) family; another familymember, Yra2p, can substitute for Yra1pfunction 0.000640.03043&radic S000003219YGL250WUncharacterizedPutative protein of unknown function; deletion mutant results in reduced PIS1 expression and has growth defects on non-fermentable carbon sources and on minimal media; GFP-fusion protein localizes to both the cytoplasm and the nucleus 0.000640.03043&radic S000003163GCN1YGL195WverifiedPositive regulator of the Gcn2p kinase activity, forms acomplex with Gcn20p; proposed to stimulateGcn2p activation by an uncharged tRNA 0.000640.03043&radic S000001420YIL158WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole 0.000640.03043&radic&radic S000005667ARP8YOR141CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes 0.000640.03043&radic S000004339KAP95YLR347CverifiedKaryopherin beta, forms a dimeric complex with Srp1p (Kap60p)that mediates nuclear import of cargo proteinsvia a nuclear localization signal (NLS),interacts with nucleoporins to guide transportacross the nuclear pore complex 0.000640.03043 S000000343YBR139WUncharacterizedPutative serine type Carboxypeptidase; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YBR139W is not an essential gene 0.000640.03042&radic&radic S000004074RAX2YLR084CverifiedN-glycosylated protein involved in the maintenance of bud siteselection during bipolar budding; localizationrequires Rax1p 0.000630.0304&radic&radic S000005600CDC21YOR074CverifiedThymidylate synthase, required for de novo biosynthesis ofpyrimidine deoxyribonucleotides; expression isinduced at G1/S 0.000630.03022&radic&radic S000002545HPR1YDR138WverifiedSubunit of THO/TREX complexes that couple transcriptionelongation with mitotic recombination and withmRNA metabolism and export, subunit of an RNAPol II complex; regulates lifespan; involved intelomere maintenance; similar to Top1p 0.000630.03022&radic S000004431MRPL4YLR439WverifiedMitochondrial ribosomal protein of the large subunit 0.000630.03022&radic&radic&radic S000000022LTE1YAL024CverifiedPutative GDP/GTP exchange factor required for mitotic exit atlow temperatures; acts as a guanine nucleotideexchange factor (GEF) for Tem1p, which is a keyregulator of mitotic exit; physicallyassociates with Ras2p-GTP 0.000630.03022&radic&radic S000006339CTF4YPR135WverifiedChromatin-associated protein, required for sister chromatidcohesion; interacts with DNA polymerase alpha(Pol1p) and may link DNA synthesis to sisterchromatid cohesion 0.000630.03022&radic S000003175SPT16YGL207WverifiedSubunit of the heterodimeric FACT complex (Spt16p-Pob3p),facilitates RNA Polymerase II transcriptionelongation through nucleosomes by destabilizingand then reassembling nucleosome structure 0.000620.02986&radic S000003054MAD1YGL086WverifiedCoiled-coil protein involved in the spindle-assemblycheckpoint; phosphorylated by Mps1p uponcheckpoint activation which leads to inhibitionof the activity of the anaphase promotingcomplex; forms a complex with Mad2p 0.000620.02976 S000005773SRL1YOR247WverifiedMannoprotein that exhibits a tight association with the cellwall, required for cell wall stability in theabsence of GPI-anchored mannoproteins; has ahigh serine-threonine content; expression isinduced in cell wall mutants 0.000620.02976&radic&radic&radic S000001750UTH1YKR042WverifiedMitochondrial outer membrane and cell wall localized SUN familymember required for mitochondrial autophagy;involved in the oxidative stress response, lifespan during starvation, mitochondrialbiogenesis, and cell death 0.000620.02969&radic&radic S000004603CDC5YMR001CverifiedPolo-like kinase with similarity to Xenopus Plx1 and S. pombePlo1p; found at bud neck, nucleus and SPBs; hasmultiple functions in mitosis and cytokinesisthrough phosphorylation of substrates; may be aCdc28p substrate 0.000620.02969&radic S000004528RPS1BYML063WverifiedRibosomal protein 10 (rp10) of the small (40S) subunit; nearlyidentical to Rps1Ap and has similarity to ratS3a ribosomal protein 0.000620.02969&radic&radic S000004527MFT1YML062CverifiedSubunit of the THO complex, which is a nuclear complexcomprised of Hpr1p, Mft1p, Rlr1p, and Thp2p,that is involved in transcription elongationand mitotic recombination; involved in telomeremaintenance 0.000610.02946&radic S000000833YPT31YER031CverifiedGTPase of the Ypt/Rab family, very similar to Ypt32p; involvedin the exocytic pathway; mediates intra-Golgitraffic or the budding of post-Golgi vesiclesfrom the trans-Golgi 0.000610.02946&radic S000000253REB1YBR049CverifiedRNA polymerase I enhancer binding protein; DNA binding proteinwhich binds to genes transcribed by both RNApolymerase I and RNA polymerase II; requiredfor termination of RNA polymerase Itranscription 0.000610.02946&radic S000000896PUP3YER094CverifiedBeta subunit of the 20S proteasome involved inubiquitin-dependent catabolism; human homologis subunit C10 0.000610.02937&radic&radic S000005218YNL274CUncharacterizedPutative hydroxyisocaproate dehydrogenase 0.000610.02937&radic&radic S000002865TOM1YDR457WverifiedE3 ubiquitin ligase of the hect-domain class; has a role inmRNA export from the nucleus and may regulatetranscriptional coactivators 0.000610.02921&radic&radic S000002909PLM2YDR501WverifiedProtein required for partitioning of the 2-micron plasmid 0.00060.02892&radic&radic&radic S000005256RFA2YNL312WverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 0.00060.02892&radic&radic S000000818BIM1YER016WverifiedMicrotubule-binding protein that together with Kar9p makes upthe cortical microtubule capture site anddelays the exit from mitosis when the spindleis oriented abnormally 0.00060.02892 S000001074YHR032WUncharacterizedPutative protein of unknown function 0.00060.02892&radic&radic S000001767TIF1YKR059WverifiedTranslation initiation factor eIF4A, identical to Tif2p;DEA(D/H)-box RNA helicase that couples ATPaseactivity to RNA binding and unwinding; forms adumbbell structure of two compact domainsconnected by a linker; interacts with eIF4G 0.00060.02892&radic S000002557NUM1YDR150WverifiedProtein required for nuclear migration, localizes to the mothercell cortex and the bud tip; may mediateinteractions of dynein and cytoplasmicmicrotubules with the cell cortex 0.00060.02892&radic&radic S000005483HRP1YOL123WverifiedSubunit of cleavage factor I, a five-subunit complex requiredfor the cleavage and polyadenylation ofpre-mRNA 3' ends; RRM-containing heteronuclearRNA binding protein and hnRNPA/B family memberthat binds to poly (A) signal sequences 0.00060.02892&radic S000000770IES6YEL044WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.00060.02883&radic S000000071KIN3YAR018CverifiedNonessential protein kinase with unknown cellular role 0.000590.02875&radic&radic S000000296PHO3YBR092CverifiedConstitutively expressed acid phosphatase similar to Pho5p;brought to the cell surface by transportvesicles; hydrolyzes thiamin phosphates in theperiplasmic space, increasing cellular thiaminuptake; expression is repressed by thiamin 0.000590.02863&radic S000005001OCA2YNL056WuncharacterizedPutative protein with similarity to predicted tyrosinephosphatases Oca1p and Siw14p; greenfluorescent protein (GFP)-fusion proteinlocalizes to the cytoplasm; YNL056W is not anessential gene 0.000590.02863 S000003628HPR5YJL092WverifiedDNA helicase and DNA-dependent ATPase involved in DNA repair,required for proper timing of commitment tomeiotic recombination and the transition fromMeiosis I to Meiosis II; potential Cdc28psubstrate 0.000590.02863&radic S000000926DSE1YER124CverifiedDaughter cell-specific protein, may participate in pathwaysregulating cell wall metabolism; deletionaffects cell separation after division andsensitivity to drugs targeted against the cellwall 0.000590.02863&radic&radic S000002771ESC2YDR363WverifiedProtein involved in mating-type locus silencing, interacts withSir2p; probably functions to recruit orstabilize Sir proteins 0.000590.02863&radic S000002726MCM21YDR318WverifiedProtein involved in minichromosome maintenance; component ofthe COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p)that bridges kinetochore subunits that are incontact with centromeric DNA and the subunitsbound to microtubules 0.000590.02841&radic S000003852BUD4YJR092WverifiedProtein involved in bud-site selection and required for axialbudding pattern; localizes with septins to budneck in mitosis and may constitute an axiallandmark for next round of budding; potentialCdc28p substrate 0.000590.02841&radic&radic S000004802SGS1YMR190CverifiedNucleolar DNA helicase of the RecQ family involved inmaintenance of genome integrity, regulateschromosome synapsis and meiotic crossing over;has similarity to human BLM and WRN helicasesimplicated in Bloom and Werner syndromes 0.000580.02725&radic S000003807TAH11YJR046WverifiedDNA replication licensing factor, required for pre-replicationcomplex assembly 0.000570.02725&radic S000002555KGD2YDR148CverifiedDihydrolipoyl transsuccinylase, a component of themitochondrial alpha-ketoglutarate dehydrogenasecomplex, which catalyzes a step in thetricarboxylic acid (TCA) cycle, the oxidativedecarboxylation of alpha-ketoglutarate tosuccinyl-CoA 0.000580.02725&radic&radic S000003626DPB11YJL090CverifiedEssential BRCT repeat protein, required on the prereplicativecomplex at replication origins for loading DNApolymerases to initiate DNA synthesis, alsorequired for S/M checkpoint control 0.000580.02725&radic S000001919PES4YFR023WverifiedPoly(A) binding protein, suppressor of DNA polymerase epsilonmutation, similar to Mip6p 0.000580.02725&radic&radic S000006177CLN2YPL256CverifiedG1 cyclin involved in regulation of the cell cycle; activatesCdc28p kinase to promote the G1 to S phasetransition; late G1 specific expression dependson transcription factor complexes, MBF(Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) 0.000570.02724&radic S000002139YAL056C-ADubiousHypothetical protein 0.000570.02717&radic S000005946YPL025CDubiousHypothetical protein 0.000570.02717&radic S000005872YOR345CDubiousHypothetical protein 0.000570.02717&radic S000000268YBR064WDubiousDubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C 0.000570.02717&radic S000006063YPL142CDubiousHypothetical protein 0.000570.02717&radic S000005118YNL174WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene NOP13/YNL175C 0.000570.02717&radic S000006159YPL238CDubiousHypothetical protein; open reading frame overlaps 5' end of essential SUI3 gene encoding a translation initiation factor subunit 0.000570.02717&radic S000006257YPR053CDubiousHypothetical protein 0.000570.02717&radic S000003167YGL199CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W 0.000570.02717&radic S000001237MDM31YHR194WverifiedMitochondrial inner membrane protein with similarity to Mdm32p,required for normal mitochondrial morphologyand inheritance; interacts genetically withMMM1, MDM10, MDM12, and MDM34 0.000560.02659&radic&radic S000001872FRS2YFL022CverifiedAlpha subunit of cytoplasmic phenylalanyl-tRNA synthetase,forms a tetramer with Frs1p to form activeenzyme; evolutionarily distant frommitochondrial phenylalanyl-tRNA synthetasebased on protein sequence, but substratebinding is similar 0.000550.02659&radic&radic S000005929CHL1YPL008WverifiedConserved nuclear protein required to establishsister-chromatid pairing during S-phase,probable DNA helicase with similarity to humanBACH1, which associates with tumor suppressorBRCA1; associates with acetyltransferase Ctf7p 0.000560.02659&radic S000006082BEM4YPL161CverifiedProtein involved in establishment of cell polarity and budemergence; interacts with the Rho1p smallGTP-binding protein and with the Rho-typeGTPase Cdc42p; involved in maintenance ofproper telomere length 0.000550.02659&radic S000003082YGL114WUncharacterizedPutative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters 0.000560.02659&radic&radic S000000927RSP5YER125WverifiedUbiquitin-protein ligase involved in ubiquitin-mediated proteindegradation; plays a role in heat shock element(HSE)-mediated gene expression andmultivesicular body sorting; contains a hect(homologous to E6-AP carboxyl terminus) domain 0.000560.02659&radic&radic S000005756WTM1YOR230WverifiedTranscriptional repressor involved in regulation of meiosis andsilencing; contains WD repeats 0.000560.02659&radic S000002504MSH6YDR097CverifiedProtein required for mismatch repair in mitosis and meiosis,forms a complex with Msh2p to repair bothsingle-base & insertion-deletion mispairs;potentially phosphorylated by Cdc28p 0.000550.0265&radic&radic S000006345KAR3YPR141CverifiedMinus-end-directed microtubule motor that functions in mitosisand meiosis, localizes to the spindle pole bodyand localization is dependent on functionalCik1p, required for nuclear fusion duringmating; potential Cdc28p substrate 0.000550.0265&radic S000004529TEM1YML064CverifiedGTP-binding protein of the ras superfamily involved intermination of M-phase; controls actomyosin andseptin dynamics during cytokinesis 0.000550.0265&radic&radic S000003461SMI1YGR229CverifiedProtein involved in the regulation of cell wall synthesis;proposed to be involved in coordinating cellcycle progression with cell wall integrity 0.000550.02625&radic S000003494BUD32YGR262CverifiedProtein kinase proposed to be involved in bud-site selection,telomere uncapping and elongation, andtranscription; component of the EKC/KEOPSprotein complex with Kae1p, Cgi121p, Pcc1p, andGon7p 0.000540.02625&radic&radic S000006062YPL141CUncharacterizedHypothetical protein 0.000550.02625&radic S000004651CSM3YMR048WverifiedProtein required for accurate chromosome segregation duringmeiosis 0.000540.0261&radic S000001022ECM29YHL030WverifiedMajor component of the proteasome; tethers the proteasome coreparticle to the regulatory particle, andenhances the stability of the proteasome 0.000540.0261&radic S000004329VRP1YLR337CverifiedProline-rich actin-associated protein involved in cytoskeletalorganization and cytokinesis; related tomammalian Wiskott-Aldrich syndrome protein(WASP)-interacting protein (WIP) 0.000540.02598 S000000615HSP30YCR021CverifiedHydrophobic plasma membrane localized, stress-responsiveprotein that negatively regulates theH(+)-ATPase Pma1p; induced by heat shock,ethanol treatment, weak organic acid, glucoselimitation, and entry into stationary phase 0.000540.02598 S000004362ARC18YLR370CverifiedSubunit of the ARP2/3 complex, which is required for themotility and integrity of cortical actinpatches 0.000540.02579 S000005383IFM1YOL023WverifiedMitochondrial translation initiation factor 2 0.000540.02579&radic S000002669EXG2YDR261CverifiedExo-1,3-beta-glucanase, involved in cell wall beta-glucanassembly; may be anchored to the plasmamembrane via a glycosylphosphatidylinositol(GPI) anchor 0.000530.02566&radic S000006067NOP53YPL146CverifiedNucleolar protein; involved in biogenesis of the 60S subunit ofthe ribosome; interacts with rRNA processingfactors Cbf5p and Nop2p; null mutant is viablebut growth is severely impaired 0.000530.02566&radic S000005558HMS1YOR032CverifiedBasic helix-loop-helix (bHLH) protein with similarity tomyc-family transcription factors;overexpression confers hyperfilamentous growthand suppresses the pseudohyphal filamentationdefect of a diploid mep1 mep2 homozygous nullmutant 0.000530.02566 S000002718SUM1YDR310CverifiedTranscriptional repressor required for mitotic repression ofmiddle sporulation-specific genes; involved intelomere maintenance, regulated by thepachytene checkpoint 0.000530.02566&radic S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling 0.000520.02536&radic S000003871YMR1YJR110WverifiedPhosphatidylinositol 3-phosphate [PI(3)P] phosphatase,regulates the localization and levels ofPI(3)P; involved in cytoplasm to vacuole (CVT)transport; has similarity to the conservedmyotubularin dual specificity phosphatasefamily 0.000530.02536&radic&radic S000004334FKS1YLR342WverifiedCatalytic subunit of 1,3-beta-D-glucan synthase, functionallyredundant with alternate catalytic subunitGsc2p; binds to regulatory subunit Rho1p;involved in cell wall synthesis andmaintenance; localizes to sites of cell wallremodeling 0.000520.02536 S000002796RVS167YDR388WverifiedActin-associated protein, subunit of a complex(Rvs161p-Rvs167p) involved in regulation ofactin cytoskeleton, endocytosis, and viabilityfollowing starvation or osmotic stress; homologof mammalian amphiphysin 0.000520.02536 S000006045SPC29YPL124WverifiedInner plaque spindle pole body (SPB) component, links thecentral plaque component Spc42p to the innerplaque component Spc110p; required for SPBduplication 0.000520.02512 S000004006PML1YLR016CverifiedSubunit of the RES complex, which is required for nuclearretention of unspliced pre-mRNAs; acts in thesame pathway as Pml39p and Mlp1p 0.000510.0246&radic S000004252YPT6YLR262CverifiedGTPase, Ras-like GTP binding protein involved in the secretorypathway, required for fusion ofendosome-derived vesicles with the late Golgi,maturation of the vacuolar carboxypeptidase Y;has similarity to the human GTPase, Rab6 0.000510.0246 S000000014TPD3YAL016WverifiedRegulatory subunit A of the heterotrimeric protein phosphatase2A, which also contains regulatory subunitCdc55p and either catalytic subunit Pph21p orPph22p; required for cell morphogenesis and fortranscription by RNA polymerase III 0.000510.0246&radic S000001229KOG1YHR186CverifiedSubunit of TORC1, a rapamycin-sensitive complex involved ingrowth control that contains Tor1p or Tor2p,Lst8p and Tco89p; contains four HEAT repeatsand seven WD-40 repeats; may act as a scaffoldprotein to couple TOR and its effectors 0.00050.02406 S000004363ROM2YLR371WverifiedGDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutationsare synthetically lethal with mutations inrom1, which also encodes a GEP 0.000510.02406 S000005474YOL114CUncharacterizedPutative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene 0.00050.02252 S000004559GIM5YML094WverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.000490.02252 S000005765ABP140YOR239WverifiedNonessential protein that binds actin filaments and localizesto actin patches and cables, has similarity toS-adenosylmethionine (AdoMet)-dependentmethyltransferases 0.00050.02252 S000002630YDR222WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.000490.02252 S000005430NUF2YOL069WverifiedComponent of the evolutionarily conservedkinetochore-associated Ndc80 complex(Ndc80p-Nuf2p-Spc24p-Spc25p); involved inchromosome segregation, spindle checkpointactivity and kinetochore clustering 0.00050.02252 S000004635HOF1YMR032WverifiedBud neck-localized, SH3 domain-containing protein required forcytokinesis; regulates actomyosin ring dynamicsand septin localization; interacts with theformins, Bni1p and Bnr1p, and with Cyk3p,Vrp1p, and Bni5p 0.00050.02252 S000002522YDR115WUncharacterizedPutative mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins 0.00050.02252&radic&radic S000003372CBF2YGR140WverifiedEssential kinetochore protein, component of the CBF3multisubunit complex that binds to the CDEIIIregion of the centromere; Cbf2p also binds tothe CDEII region possibly forming a differentmultimeric complex, ubiquitinated in vivo 0.000490.02252&radic S000004652ERB1YMR049CverifiedProtein required for maturation of the 25S and 5.8S ribosomalRNAs; constituent of 66S pre-ribosomalparticles; homologous to mammalian Bop1 0.000490.02252&radic&radic S000005195NRD1YNL251CverifiedRNA-binding protein that interacts with the C-terminal domainof the RNA polymerase II large subunit(Rpo21p), required for transcriptiontermination and 3' end maturation ofnonpolyadenylated RNAs 0.000490.02252&radic S000003095SOH1YGL127CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; involved in telomeremaintenance; conserved with other metazoanMED31 subunits 0.00050.02252&radic S000000322TEF2YBR118WverifiedTranslational elongation factor EF-1 alpha; also encoded byTEF1; functions in the binding reaction ofaminoacyl-tRNA (AA-tRNA) to ribosomes 0.000490.02252 S000001094CIC1YHR052WverifiedEssential protein that interacts with proteasome components andhas a potential role in proteasome substratespecificity; also copurifies with 66Spre-ribosomal particles 0.000490.02252&radic&radic S000005604BUD21YOR078WverifiedComponent of small ribosomal subunit (SSU) processosome thatcontains U3 snoRNA; originally isolated asbud-site selection mutant that displays arandom budding pattern 0.00050.02252&radic&radic S000002989ALK1YGL021WverifiedProtein kinase; accumulation and phosphorylation are periodicduring the cell cycle; phosphorylated inresponse to DNA damage; contains characteristicmotifs for degradation via the APC pathway;similar to Alk2p and to mammalian haspins 0.00050.02252&radic S000005187SLA2YNL243WverifiedTransmembrane actin-binding protein involved in membranecytoskeleton assembly and cell polarization;adaptor protein that links actin to clathrinand endocytosis; present in the actin corticalpatch of the emerging bud tip; dimer in vivo 0.00050.02252 S000004614CLU1YMR012WverifiedeIF3 component of unknown function; deletion causes defects inmitochondrial organization but not in growth ortranslation initiation, can rescue cytokinesisand mitochondrial organization defects of theDictyostelium cluA- mutant 0.00050.02252 S000001492MRT4YKL009WverifiedProtein involved in mRNA turnover and ribosome assembly,localizes to the nucleolus 0.00050.02252&radic&radic S000001897LOC1YFR001WverifiedNuclear protein involved in asymmetric localization of ASH1mRNA; binds double-stranded RNA in vitro;constituent of 66S pre-ribosomal particles 0.00050.02252&radic&radic S000003873NNF1YJR112WverifiedEssential component of the MIND kinetochore complex (Mtw1pIncluding Nnf1p-Nsl1p-Dsn1p) which joinskinetochore subunits contacting DNA to thosecontacting microtubules; required for accuratechromosome segregation 0.000490.02252 S000002744YDR336WUncharacterizedPutative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene 0.00050.02252 S000001238NVJ1YHR195WverifiedNuclear envelope protein that interacts with the vacuolarmembrane protein Vac8p to promote formation ofnucleus-vacuole junctions during piecemealmicroautophagy of the nucleus (PMN) 0.00050.02252&radic&radic S000001353YIL091CUncharacterizedProtein required for cell viability 0.000490.02238&radic&radic S000004441FPR4YLR449WverifiedPeptidyl-prolyl cis-trans isomerase (PPIase) (prolineisomerase) localized to the nucleus; catalyzesisomerization of proline residues in histonesH3 and H4, which affects lysine methylation ofthose histones 0.000490.02211&radic&radic S000003896MCM22YJR135CverifiedProtein involved in minichromosome maintenance; component ofthe kinetochore; binds to centromeric DNA in aCtf19p-dependent manner 0.000480.02211&radic S000002269RRP42YDL111CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp4p, Rrp41p,Rrp43p and Dis3p 0.000480.02184&radic&radic S000005370RCL1YOL010WverifiedRNA terminal phosphate cyclase-like protein involved in rRNAprocessing at sites A0, A1, and A2; does notpossess detectable RNA cyclase activity 0.000480.02184&radic&radic S000000536RRP7YCL031CverifiedEssential protein involved in rRNA processing and ribosomebiogenesis 0.000480.02184&radic&radic S000001486MRP17YKL003CverifiedMitochondrial ribosomal protein of the small subunit; MRP17exhibits genetic interactions with PET122,encoding a COX3-specific translationalactivator 0.000480.02184 S000004276CTS1YLR286CverifiedEndochitinase, required for cell separation after mitosis;transcriptional activation during late G andearly M cell cycle phases is mediated bytranscription factor Ace2p 0.000480.02184&radic&radic S000005553STI1YOR027WverifiedHsp90 cochaperone, interacts with the Ssa group of thecytosolic Hsp70 chaperones; activates theATPase activity of Ssa1p; homolog of mammalianHop protein 0.000480.02147 S000004021YLR031WUncharacterizedHypothetical protein 0.000480.02147 S000003335NOP7YGR103WverifiedNucleolar protein involved in rRNA processing and 60S ribosomalsubunit biogenesis; constituent of severaldifferent pre-ribosomal particles; required forexit from G0 and the initiation ofcell proliferation 0.000480.02138&radic&radic S000004736POM152YMR129WverifiedNuclear pore membrane glycoprotein; may be involved induplication of nuclear pores and nuclear porecomplexes during S-phase; 0.000470.02053 S000003321NNF2YGR089WuncharacterizedProtein that exhibits physical and genetic interactions withRpb8p, which is a subunit of RNA polymerases I,II, and III; computational analysis oflarge-scale protein-protein interaction datasuggests a role in chromosome segregation 0.000470.02053 S000004738RRB1YMR131CverifiedEssential nuclear protein involved in early steps of ribosomebiogenesis; physically interacts with theribosomal protein Rpl3p 0.000470.02053&radic&radic S000003427SKI6YGR195Wverified3'-to-5' phosphorolytic exoribonuclease that is a subunit ofthe exosome; required for 3' processing of the5.8S rRNA; involved in 3' to 5' mRNAdegradation and translation inhibition ofnon-poly(A) mRNAs 0.000470.02053&radic&radic S000005584ASE1YOR058CverifiedMember of a family of microtubule-associated proteins (MAPs)that function at the mitotic spindle midzone;required for spindle elongation; undergoes cellcycle-regulated degradation by anaphasepromoting complex; potential Cdc28p substrate 0.000480.02053 S000001504MAK11YKL021CverifiedProtein essential for cell growth and replication of M dsRNAvirus; contains four beta-transducin repeats 0.000480.02053&radic&radic S000000455MRPS5YBR251WverifiedMitochondrial ribosomal protein of the small subunit 0.000480.02053 S000003151MND1YGL183CverifiedProtein required for recombination and meiotic nucleardivision; forms a complex with Hop2p, which isinvolved in chromosome pairing and repair ofmeiotic double-strand breaks 0.000470.02046&radic S000004682VPS20YMR077CverifiedMyristoylated subunit of ESCRTIII, the endosomal sortingcomplex required for transport of transmembraneproteins into the multivesicular body pathwayto the lysosomal/vacuolar lumen; cytoplasmicprotein recruited to endosomal membranes 0.000470.02024 S000003684RPA34YJL148WverifiedRNA polymerase I subunit A34.5 0.000470.02024&radic&radic S000003727RPS14BYJL191WverifiedRibosomal protein 59 of the small subunit, required forribosome assembly and 20S pre-rRNA processing;mutations confer cryptopleurine resistance;nearly identical to Rps14Ap and similar to E.coli S11 and rat S14 ribosomal proteins 0.000460.01984&radic&radic S000003063VPS45YGL095CverifiedProtein of the Sec1p/Munc-18 family, essential for vacuolarprotein sorting; required for the function ofPep12p and the early endosome/late Golgi SNARETlg2p; essential for fusion of Golgi-derivedvesicles with the prevacuolar compartment 0.000460.01976 S000004187SIK1YLR197WverifiedEssential evolutionarily-conserved nucleolar protein componentof the box C/D snoRNP complexes that direct2'-O-methylation of pre-rRNA during itsmaturation; overexpression causes spindleorientation defects 0.000460.01976&radic S000001305CBR1YIL043CverifiedMicrosomal cytochrome b reductase, not essential for viability;also detected in mitochondria; mutation inconserved NADH binding domain of the humanortholog results in type I methemoglobinemia 0.000460.01976 S000003931DRS1YLL008WverifiedNucleolar DEAD-box protein required for ribosome assembly andfunction, including synthesis of 60S ribosomalsubunits; constituent of 66S pre-ribosomalparticles 0.000460.01976&radic&radic S000005721SLK19YOR195WverifiedKinetochore-associated protein required for normal segregationof chromosomes in meiosis and mitosis;component of the FEAR regulatory network, whichpromotes Cdc14p release from the nucleolusduring anaphase; potential Cdc28p substrate 0.000460.01976 S000000266YBR062CUncharacterizedHypothetical protein 0.000460.01955&radic S000001756NAP1YKR048CverifiedProtein that interacts with mitotic cyclin Clb2p; required forthe regulation of microtubule dynamics duringmitosis; controls bud morphogenesis; involvedin the transport of H2A and H2B histones to thenucleus 0.000450.01955 S000004322CHS5YLR330WverifiedProtein involved in export from the Golgi to plasma membrane;involved in chitin biosynthesis through itsrole in Chs3p localization; interacts withArf1p, Bch1p, Fmp50p, Bud7p, and Chs6p 0.000450.01955 S000003065SRM1YGL097WverifiedNucleotide exchange factor for Gsp1p, localizes to the nucleus,required for nucleocytoplasmic trafficking ofmacromolecules; potentially phosphorylated byCdc28p 0.000450.01935&radic S000001551NUP100YKL068WverifiedSubunit of the nuclear pore complex (NPC) that is localized toboth sides of the pore; contains a repetitiveGLFG motif that interacts with mRNA exportfactor Mex67p and with karyopherin Kap95p;homologous to Nup116p 0.000450.01935 S000006005BRO1YPL084WverifiedCytoplasmic class E vacuolar protein sorting (VPS) factor thatcoordinates deubiquitination in themultivesicular body (MVB) pathway by recruitingDoa4p to endosomes 0.000450.01935 S000000994HSE1YHL002WverifiedSubunit of the endosomal Vps27p-Hse1p complex required forsorting of ubiquitinated membrane proteins intointralumenal vesicles prior to vacuolardegradation, as well as for recycling of Golgiproteins and formation of lumenal membranes 0.000450.01935 S000001732DBP7YKR024CverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in ribosomal biogenesis 0.000450.01935&radic&radic S000005938IRC15YPL017CuncharacterizedPutative S-adenosylmethionine-dependent methyltransferase ofthe seven beta-strand family; null mutantdisplays increased levels of spontaneous Rad52foci 0.000450.01935 S000005819RPS10AYOR293WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps10Bp and has similarity to ratribosomal protein S10 0.000450.01935&radic&radic S000004186PWP1YLR196WverifiedProtein with WD-40 repeats involved in rRNA processing;associates with trans-acting ribosomebiogenesis factors; similar to beta-transducinsuperfamily 0.000450.01935&radic&radic S000001768UTP30YKR060WuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.000450.01935&radic&radic S000000298PBY1YBR094WuncharacterizedP-body associated protein 0.000450.01935 S000005440REX4YOL080CverifiedPutative RNA exonuclease possibly involved in pre-rRNAprocessing and ribosome assembly 0.000450.01934&radic&radic S000001894SPB4YFL002CverifiedPutative ATP-dependent RNA helicase, nucleolar protein requiredfor synthesis of 60S ribosomal subunits at alate step in the pathway; sediments with 66Spre-ribosomes in sucrose gradients 0.000450.01929&radic&radic S000000124YBL028CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis 0.000450.01929&radic&radic S000003313SLX9YGR081CverifiedProtein of unknown function; deletion mutant has syntheticfitness defect with an sgs1 deletion mutant 0.000440.01915&radic&radic S000005003YNL058CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene 0.000440.01915 S000001069RPN1YHR027CverifiedNon-ATPase base subunit of the 19S regulatory particle of the26S proteasome; may participate in therecognition of several ligands of theproteasome; contains a leucine-rich repeat(LRR) domain, a site for protein?proteininteractions 0.000440.01915&radic S000002657YDR249CUncharacterizedHypothetical protein 0.000450.01915 S000000286UBC4YBR082CverifiedUbiquitin-conjugating enzyme that mediates degradation ofshort-lived and abnormal proteins; interactswith E3-CaM in ubiquitinating calmodulin;interacts with many SCF ubiquitin proteinligases; component of the cellular stressresponse 0.000450.01915&radic S000001123LRP1YHR081WverifiedSubstrate-specific nuclear cofactor for exosome activity in theprocessing of stable RNAs; required fortelomere length maintenance; homolog ofmammalian nuclear matrix protein C1D involvedin regulation of DNA repair and recombination 0.000440.01915 S000004584ATR1YML116WverifiedMultidrug efflux pump of the major facilitator superfamily,required for resistance to aminotriazole and4-nitroquinoline-N-oxide 0.000450.01915&radic S000003202SEC15YGL233WverifiedEssential 113kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which mediates polarized targeting ofvesicles to active sites of exocytosis; Sec15passociates with Sec4p and vesicles 0.000450.01915 S000002662CHL4YDR254WverifiedOuter kinetochore protein required for chromosome stability,interacts with kinetochore proteins Ctf19p,Ctf3p, and Iml3p; exhibits a two-hybridinteraction with Mif2p; association with CENDNA requires Ctf19p 0.000440.01907 S000001921HIS2YFR025CverifiedHistidinolphosphatase, catalyzes the eighth step in histidinebiosynthesis; mutations cause histidineauxotrophy and sensitivity to Cu, Co, and Nisalts; transcription is regulated by generalamino acid control 0.000440.01907 S000004967YNL022CUncharacterizedPutative protein of unknown function with seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to a single spot in the nucleus; YNL022C is not an essential gene 0.000440.01907&radic&radic S000004625MSS1YMR023CverifiedMitochondrial protein, forms a heterodimer complex with Mto1pthat performs the 5-carboxymethylaminomethylmodification of the wobble uridine base inmitochondrial tRNAs; similar to human GTPBP3 0.000440.019 S000003327RRP46YGR095CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex 0.000440.0189&radic&radic S000005758MGE1YOR232WverifiedProtein of the mitochondrial matrix involved in protein importinto mitochondria; acts as a cochaperone and anucleotide release factor for Ssc1p; homolog ofE. coli GrpE 0.000440.0189 S000004520IMD4YML056CverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 0.000440.0189 S000005606DIA2YOR080WverifiedOrigin-binding F-box protein that forms an SCF ubiquitin ligasecomplex with Skp1p and Cdc53p; plays a role inDNA replication, involved in invasive andpseudohyphal growth 0.000440.01888 S000004514YML050WUncharacterizedHypothetical protein 0.000440.01888&radic S000004045SPT8YLR055CverifiedSubunit of the SAGA transcriptional regulatory complex but notpresent in SAGA-like complex SLIK/SALSA,required for SAGA-mediated inhibition at somepromoters 0.000430.01861&radic S000002767VID21YDR359CverifiedComponent of the NuA4 histone acetyltransferase complex 0.000430.01861 S000003719MNN11YJL183WverifiedSubunit of a Golgi mannosyltransferase complex that alsocontains Anp1p, Mnn9p, Mnn10p, and Hoc1p, andmediates elongation of the polysaccharidemannan backbone; has homology to Mnn10p 0.000430.01861 S000004415ATG17YLR423CverifiedProtein that interacts with and is required for activation ofApg1p protein kinase; involved in autophagy butnot in the Cvt (cytoplasm to vacuole targeting)pathway 0.000430.01861 S000004795SSO2YMR183CverifiedPlasma membrane t-SNARE involved in fusion of secretoryvesicles at the plasma membrane; syntaxinhomolog that is functionally redundant withSso1p 0.000430.01861 S000000834FIR1YER032WverifiedProtein involved in 3' mRNA processing, interacts with Ref2p;potential Cdc28p substrate 0.000430.01861 S000003863VPS25YJR102CverifiedComponent of the ESCRT-II complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome 0.000420.01839 S000005939CTF19YPL018WverifiedOuter kinetochore protein, required for accurate mitoticchromosome segregation; component of thekinetochore sub-complex COMA (Ctf19p, Okp1p,Mcm21p, Ame1p) that functions as a platform forkinetochore assembly 0.000420.01839 S000004796ADD37YMR184WuncharacterizedProtein of unknown function involved in ER-associated proteindegradation; green fluorescent protein(GFP)-fusion protein localizes to thecytoplasm; YMR184W is not an essential gene 0.000420.01831 S000000103SLA1YBL007CverifiedCytoskeletal protein binding protein required for assembly ofthe cortical actin cytoskeleton; contains 3 SH3domains; interacts with proteins regulatingactin dynamics and with proteins required forendocytosis 0.000420.01831 S000004378VAC14YLR386WverifiedProtein involved in regulated synthesis of PtdIns(3,5)P(2), incontrol of trafficking of some proteins to thevacuole lumen via the MVB, and in maintenanceof vacuole size and acidity; activator of Fab1p 0.000420.01831 S000004075ARP6YLR085CverifiedActin-related protein that binds nucleosomes; a component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.000420.01796&radic S000005169CNM67YNL225CverifiedComponent of the spindle pole body outer plaque; required forspindle orientation and mitotic nuclearmigration 0.000420.01796 S000000619PMP1YCR024C-AverifiedSmall single-membrane span proteolipid that functions as aregulatory subunit of the plasma membraneH(+)-ATPase Pma1p, forms unique helix andpositively charged cytoplasmic domain that isable to specifically segregatephosphatidylserines 0.000410.01754 S000001907YFR011CUncharacterizedPutative protein of unknown function; localizes to the mitochondrion; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR011C is not an essential gene 0.000410.01754 S000003701HAL5YJL165CverifiedPutative protein kinase; overexpression increases sodium andlithium tolerance, whereas gene disruptionincreases cation and low pH sensitivity andimpairs potassium uptake, suggesting a role inregulation of Trk1p and/or Trk2p transporters 0.000410.01754 S000005120YNL176CUncharacterizedHypothetical protein 0.000410.01754&radic S000003797HUL4YJR036CverifiedProtein with similarity to hect domain E3 ubiquitin-proteinligases, not essential for viability 0.000410.01754 S000004597MSC1YML128CverifiedProtein of unknown function; mutant is defective in directingmeiotic recombination events to homologouschromatids; the authentic, non-tagged proteinis detected in highly purified mitochondria inhigh-throughput studies 0.000410.01722 S000000052GPB2YAL056WverifiedProposed beta subunit of the heterotrimeric G protein;interacts with the receptor Grp1p, affectssignaling by altering the level ofphosphorylation of PKS substrates; regulatespseudohyphal growth through cAMP levels;homolog of Gpb1p 0.000410.01709&radic S000002243NDE2YDL085WverifiedMitochondrial external NADH dehydrogenase, catalyzes theoxidation of cytosolic NADH; Nde1p and Nde2pare involved in providing the cytosolic NADH tothe mitochondrial respiratory chain 0.00040.01671 S000000968DNF1YER166WverifiedAminophospholipid translocase (flippase) that localizesprimarily to the plasma membrane; contributesto endocytosis, protein transport and cellpolarity; type 4 P-type ATPase 0.00040.01671 S000004373CTF3YLR381WverifiedOuter kinetochore protein that forms a complex with Mcm16p andMcm22p; may bind the kinetochore to spindlemicrotubules 0.00040.01671 S000001015RMD11YHL023CverifiedProtein required for sporulation 0.00040.01671&radic S000000514STP22YCL008CverifiedComponent of the ESCRT-I complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; homologous to the mouse and humanTsg101 tumor susceptibility gene; mutantsexhibit a Class E Vps phenotype 0.00040.01671 S000005473SKM1YOL113WverifiedMember of the PAK family of serine/threonine protein kinaseswith similarity to Ste20p and Cla4p; proposedto be a downstream effector of Cdc42p duringpolarized growth 0.00040.01671 S000006276NOT5YPR072WverifiedSubunit of the CCR4-NOT complex, which is a globaltranscriptional regulator with roles intranscription initiation and elongation and inmRNA degradation 0.00040.01667 S000003999RLP24YLR009WverifiedRibosomal Like Protein 24 0.00040.01667 S000004029RIC1YLR039CverifiedProtein involved in retrograde transport to the cis-Golginetwork; forms heterodimer with Rgp1p that actsas a GTP exchange factor for Ypt6p; involved intranscription of rRNA and ribosomal proteingenes 0.00040.01652 S000003062PAN2YGL094CverifiedEssential subunit of the Pan2p-Pan3p poly(A)-ribonucleasecomplex, which acts to control poly(A) taillength and regulate the stoichiometry andactivity of postreplication repair complexes 0.00040.01592 S000001801PTR2YKR093WverifiedIntegral membrane peptide transporter, mediates transport ofdi- and tri-peptides; conserved protein thatcontains 12 transmembrane domains; PTR2expression is regulated by the N-end rulepathway via repression by Cup9p 0.000390.01592 S000003121PEX14YGL153WverifiedPeroxisomal membrane protein that is a central component of theperoxisomal protein import machinery, interactswith PTS1 (Pex5p) and PTS2 (Pex7p) peroxisomalmatrix protein signal recognition factors andmembrane receptor Pex13p 0.000390.01592 S000002536SAC6YDR129CverifiedFimbrin, actin-bundling protein; cooperates with Scp1p(calponin/transgelin) in the organization andmaintenance of the actin cytoskeleton 0.000390.01592 S000000308YMC2YBR104WverifiedPutative mitochondrial inner membrane transporter, member ofthe mitochondrial carrier (MCF) family 0.000390.01537 S000000094PHO11YAR071WverifiedOne of three repressible acid phosphatases, a glycoprotein thatis transported to the cell surface by thesecretory pathway; induced by phosphatestarvation and coordinately regulated by PHO4and PHO2 0.000390.01537 S000001790NUP133YKR082WverifiedSubunit of the Nup84p subcomplex of the nuclear pore complex(NPC), localizes to both sides of the NPC,required to establish a normalnucleocytoplasmic concentration gradient of theGTPase Gsp1p 0.000390.01537 S000000602RVS161YCR009CverifiedAmphiphysin-like lipid raft protein; subunit of a complex(Rvs161p-Rvs167p) that regulates polarizationof the actin cytoskeleton, endocytosis, cellpolarity, cell fusion and viability followingstarvation or osmotic stress 0.000390.01537 S000000673PAT1YCR077CverifiedTopoisomerase II-associated deadenylation-dependentmRNA-decapping factor; also required forfaithful chromosome transmission, maintenanceof rDNA locus stability, and protection of mRNA3'-UTRs from trimming; functionally linked toPab1p 0.000390.01537 S000004295ACO1YLR304CverifiedAconitase, required for the tricarboxylic acid (TCA) cycle andalso independently required for mitochondrialgenome maintenance; component of themitochondrial nucleoid; mutation leads toglutamate auxotrophy 0.000390.01537 S000005334BRE5YNR051CverifiedUbiquitin protease cofactor, forms deubiquitination complexwith Ubp3p that coregulates anterograde andretrograde transport between the endoplasmicreticulum and Golgi compartments; null issensitive to brefeldin A 0.000390.01537 S000005028END3YNL084CverifiedEH domain-containing protein involved in endocytosis, actincytoskeletal organization and cell wallmorphogenesis; forms a complex with Sla1p andPan1p 0.000380.01452 S000004476TRM9YML014WverifiedtRNA methyltransferase, catalyzes the esterification ofmodified uridine nucleotides in tRNAs, creating5-methylcarbonylmethyluridine in tRNA(Arg3) and5-methylcarbonylmethyl-2-thiouridine intRNA(Glu); may have a role in stress response 0.000380.01452 S000004181PEX13YLR191WverifiedIntegral peroxisomal membrane receptor for the PTS1 peroxisomalmatrix protein signal recognition factor Pex5p,required for the translocation of peroxisomalmatrix proteins, also interacts with Pex7p andPex14p, contains a C-terminal SH3 domain 0.000380.01452 S000004992SLM2YNL047CverifiedPhosphoinositide PI4,5P(2) binding protein, forms a complexwith Slm1p; acts downstream of Mss4p in apathway regulating actin cytoskeletonorganization in response to stress; subunit ofand phosphorylated by the TORC2 complex 0.000380.01452&radic S000002897SLD5YDR489WverifiedSubunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), whichis localized to DNA replication origins andimplicated in assembly of the DNA replicationmachinery 0.000380.01452 S000005923SNF8YPL002CverifiedComponent of the ESCRT-II complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; appears to be functionallyrelated to SNF7; involved in glucosederepression 0.000380.01408 S000000261MUM2YBR057CverifiedCytoplasmic protein essential for meiotic DNA replication andsporulation; interacts with Orc2p, which is acomponent of the origin recognition complex 0.000380.01408&radic S000003948PAU17YLL025WuncharacterizedPutative protein of unknown function; YLL025W is not anessential gene 0.000370.01398 S000005043OCA1YNL099CverifiedPutative protein tyrosine phosphatase, required for cell cyclearrest in response to oxidative damage of DNA 0.000370.0138 S000004991YNL046WUncharacterizedPutative protein of unknown function; expression depends on Swi5p; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL046W is not an essential gene 0.000370.0135&radic S000003406CBP4YGR174CverifiedMitochondrial protein required for assembly of ubiquinolcytochrome-c reductase complex (cytochrome bc1complex); interacts with Cbp3p and function ispartially redundant with that of Cbp3p 0.000370.0135 S000002905ITR1YDR497CverifiedMyo-inositol transporter with strong similarity to the minormyo-inositol transporter Itr2p, member of thesugar transporter superfamily; expression isrepressed by inositol and choline via Opi1p andderepressed via Ino2p and Ino4p 0.000370.0135 S000003394TIF4631YGR162WverifiedTranslation initiation factor eIF4G, subunit of the mRNAcap-binding protein complex (eIF4F) that alsocontains eIF4E (Cdc33p); associates with thepoly(A)-binding protein Pab1p, also interactswith eIF4A (Tif1p); homologous to Tif4632p 0.000370.0135 S000005274RPD3YNL330CverifiedHistone deacetylase; regulates transcription and silencing 0.000370.0135&radic S000004669KAR5YMR065WverifiedProtein required for nuclear membrane fusion during karyogamy,localizes to the membrane with a solubleportion in the endoplasmic reticulum lumen, mayform a complex with Jem1p and Kar2p; expressionof the gene is regulated by pheromone 0.000370.0135 S000004050FRS1YLR060WverifiedBeta subunit of cytoplasmic phenylalanyl-tRNA synthetase, formsa tetramer with Frs2p to generate activeenzyme; sequence is evolutionarily distant frommitochondrial phenylalanyl-tRNA synthetase(Msf1p), but substrate binding is similar 0.000360.01334&radic S000000744EAF5YEL018WuncharacterizedEsa1p-associated factor, subunit of the NuA4 acetyltransferasecomplex 0.000360.01291&radic S000004467ERG6YML008CverifiedDelta(24)-sterol C-methyltransferase, converts zymosterol tofecosterol in the ergosterol biosyntheticpathway by methylating position C-24; localizedto both lipid particles and mitochondrial outermembrane 0.000350.01278 S000005535TIR4YOR009WverifiedCell wall mannoprotein of the Srp1p/Tip1p family ofserine-alanine-rich proteins; expressed underanaerobic conditions and required for anaerobicgrowth; transcription is also induced by coldshock 0.000350.01275 S000004985YNL040WUncharacterizedPutative protein of unknown function with strong similarity to alanyl-tRNA synthases from Eubacteria; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL040W is not an essential gene 0.000350.01243&radic S000004424IMD3YLR432WverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 0.000350.01243 S000000297PHO5YBR093CverifiedRepressible acid phosphatase (1 of 3) that also mediatesextracellular nucleotide-derived phosphatehydrolysis; secretory pathway derived cellsurface glycoprotein; induced by phosphatestarvation and coordinately regulated by PHO4and PHO2 0.000350.01243 S000000572HMLALPHA2YCL067CverifiedSilenced copy of ALPHA2 at HML; homeobox-domain protein thatassociates with Mcm1p in haploid cells torepress a-specific gene expression andinteracts with a1p in diploid cells to represshaploid-specific gene expression 0.000350.01243 S000003340CLB1YGR108WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the transition from G2 to Mphase; accumulates during G2 and M, thentargeted via a destruction box motif forubiquitin-mediated degradation by theproteasome 0.000350.01243&radic S000006259SEC8YPR055WverifiedEssential 121kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which has the essential function ofmediating polarized targeting of secretoryvesicles to active sites of exocytosis 0.000350.01235&radic S000004224TOP3YLR234WverifiedDNA Topoisomerase III, conserved protein that functions in acomplex with Sgs1p and Rmi1p to relaxsingle-stranded negatively-supercoiled DNApreferentially, involved in telomere stabilityand regulation of mitotic recombination 0.000350.01235&radic S000001021OCA5YHL029CuncharacterizedCytoplasmic protein required for replication of Brome mosaicvirus in S. cerevisiae, which is a model systemfor studying replication of positive-strand RNAviruses in their natural hosts 0.000340.0122 S000003746PEX2YJL210WverifiedRING-finger peroxin, peroxisomal membrane protein with aC-terminal zinc-binding RING domain, formsputative translocation subcomplex with Pex10pand Pex12p which functions in peroxisomalmatrix protein import 0.000340.01191 S000003288RSC1YGR056WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; containstwo essential bromodomains, a bromo-adjacenthomology (BAH) domain, and an AT hook 0.000340.01191 S000000258YRO2YBR054WverifiedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies;transcriptionally regulated by Haa1p 0.000340.01191 S000001319YIL057CUncharacterizedHypothetical protein 0.000340.01173&radic S000006163IQG1YPL242CverifiedEssential protein required for determination of buddingpattern, promotes localization of axial markersBud4p and Cdc12p and functionally interactswith Sec3p, localizes to the contractile ringduring anaphase, member of the IQGAP family 0.000330.01155 S000005933RRP12YPL012WverifiedProtein required for export of the ribosomal subunits;associates with the RNA components of thepre-ribosomes; contains HEAT-repeats 0.000330.01143&radic S000005241MON2YNL297CverifiedPeripheral membrane protein with a role in endocytosis andvacuole integrity, interacts with Arl1p andlocalizes to the endosome; member of the Sec7pfamily of proteins 0.000330.01143 S000005143GCR2YNL199CverifiedTranscriptional activator of genes involved in glycolysis;interacts and functions with the DNA-bindingprotein Gcr1p 0.000330.01137 S000004844PEP5YMR231WverifiedPeripheral vacuolar membrane protein required for proteintrafficking and vacuole biogenesis; formscomplex with Pep3p that promotes vesiculardocking/fusion reactions in conjunction withSNARE proteins, also interacts with Pep7p 0.000330.01137 S000003462BNS1YGR230WverifiedProtein with some similarity to Spo12p; overexpression bypassesneed for Spo12p, but not required for meiosis 0.000330.01128&radic S000000814PRE1YER012Wverified20S proteasome beta-type subunit; localizes to the nucleusthroughout the cell cycle 0.000330.01128 S000002374GDH2YDL215CverifiedNAD(+)-dependent glutamate dehydrogenase, degrades glutamate toammonia and alpha-ketoglutarate; expressionsensitive to nitrogen catabolite repression andintracellular ammonia levels 0.000320.01046&radic S000000787CIN8YEL061CverifiedKinesin motor protein involved in mitotic spindle assembly andchromosome segregation 0.000310.00983 S000004138PEP3YLR148WverifiedVacuolar peripheral membrane protein that promotes vesiculardocking/fusion reactions in conjunction withSNARE proteins, required for vacuolarbiogenesis, forms complex with Pep5p thatmediates protein transport to the vacuole 0.000310.00983 S000005097GIM3YNL153CverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.000310.00936 S000006046KAP120YPL125WverifiedKaryopherin with a role in the assembly or export of 60Sribosomal subunits 0.000310.00936&radic S000004490TSA1YML028WverifiedUbiquitous housekeeping thioredoxin peroxidase, reducesreactive oxygen, nitrogen and sulfur speciesusing thioredoxin as hydrogen donor; mediatesredox regulation of the nuclear localization ofYap1p; deletion results in mutator phenotype 0.00030.00851&radic S000005133SRP1YNL189WverifiedKaryopherin alpha homolog, forms a dimer with karyopherin betaKap95p to mediate import of nuclear proteins,binds the nuclear localization signal of thesubstrate during import; may also play a rolein regulation of protein degradation 0.00030.00851 S000002473YDR066CUncharacterizedHypothetical protein 0.00030.00851 S000004986COG6YNL041CverifiedComponent of the conserved oligomeric Golgi complex (Cog1pthrough Cog8p), a cytosolic tethering complexthat functions in protein trafficking tomediate fusion of transport vesicles to Golgicompartments 0.00030.00851&radic S000002667YAP6YDR259CverifiedPutative basic leucine zipper (bZIP) transcription factor;overexpression increases sodium and lithiumtolerance 0.000290.00822&radic S000002982PUF4YGL014WverifiedMember of the PUF protein family, which is defined by thepresence of Pumilio homology domains thatconfer RNA binding activity; preferentiallybinds mRNAs encoding nucleolar ribosomalRNA-processing factors 0.000290.00789 S000004093CDC45YLR103CverifiedDNA replication initiation factor; recruited to MCM pre-RCcomplexes at replication origins; promotesrelease of MCM from Mcm10p, recruits elongationmachinery; mutants in human homolog may causevelocardiofacial and DiGeorge syndromes 0.000290.00762&radic&radic S000004633YMR031CUncharacterizedPutative protein of unknown function with similarity to YKL050C and USO1/YDL058W; found in mitochondria; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR031C is not an essential gene 0.000280.00706 S000002484SED1YDR077WverifiedMajor stress-induced structural GPI-cell wall glycoprotein instationary-phase cells, associates withtranslating ribosomes, possible role inmitochondrial genome maintenance; ORF containstwo distinct variable minisatellites 0.000280.00706 S000000275YBR071WUncharacterizedHypothetical protein 0.000280.00702&radic S000001043OSH7YHR001WverifiedMember of an oxysterol-binding protein family with sevenmembers in S. cerevisiae; family members haveoverlapping, redundant functions in sterolmetabolism and collectively perform a functionessential for viability 0.000280.00702 S000001913YFR017CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR017C is not an essential gene 0.000270.00681&radic S000001595ABF1YKL112WverifiedDNA binding protein with possible chromatin-reorganizingactivity involved in transcriptionalactivation, gene silencing, and DNA replicationand repair 0.000270.00679&radic&radic S000003341CLB6YGR109CverifiedB-type cyclin involved in DNA replication during S phase;activates Cdc28p to promote initiation of DNAsynthesis; functions in formation of mitoticspindles along with Clb3p and Clb4p; mostabundant during late G1 0.000270.00679&radic S000004409VPS36YLR417WverifiedComponent of the ESCRT-II complex; contains the GLUE (GRAM LikeUbiquitin binding in EAP45) domain which isinvolved in interactions with ESCRT-I andubiquitin-dependent sorting of proteins intothe endosome 0.000270.00653 S000002544RGP1YDR137WverifiedSubunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) thatcatalyzes nucleotide exchange on Ypt6p 0.000270.00615 S000002936HLR1YDR528WverifiedProtein involved in regulation of cell wall composition andintegrity and response to osmotic stress;overproduction suppresses a lysis sensitive PKCmutation; similar to Lre1p, which functionsantagonistically to protein kinase A 0.000270.00615&radic S000006394RPC82YPR190CverifiedRNA polymerase III subunit C82 0.000270.00615&radic S000003165MDS3YGL197WverifiedProtein with an N-terminal kelch-like domain, putative negativeregulator of early meiotic gene expression;required, with Pmd1p, for growth under alkalineconditions 0.000270.00615&radic S000006347RRP15YPR143WverifiedNucleolar protein, constituent of pre-60S ribosomal particles;required for processing of the 27S pre-rRNA atthe A2 site to yield 5.8S and 25S rRNA 0.000270.00615&radic&radic S000001887BLM10YFL007WverifiedProteosome activator subunit; found in association with coreparticles, with and without the 19S regulatoryparticle; required for resistance to bleomycin,may be involved in protecting against oxidativedamage; similar to mammalian PA200 0.000270.00615&radic S000004389AFG2YLR397CverifiedATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexamericcomplex; may be involved in degradation ofaberrant mRNAs 0.000270.00615&radic S000001609YPK1YKL126WverifiedSerine/threonine protein kinase required for receptor-mediatedendocytosis; involved in sphingolipid-mediatedand cell integrity signaling pathways;localized to the bud neck, cytosol and plasmamembrane; homolog of mammalian kinase SGK 0.000260.00586&radic S000002803SXM1YDR395WverifiedNuclear transport factor (karyopherin) involved in proteintransport between the cytoplasm andnucleoplasm; similar to Nmd5p, Cse1p, Lph2p,and the human cellular apoptosis susceptibilityprotein, CAS1 0.000260.00586&radic S000003210KAP114YGL241WverifiedKaryopherin, responsible for nuclear import of Spt15p, histonesH2A and H2B, and Nap1p; amino terminus showssimilarity to those of other importins,particularly Cse1p; localization is primarilynuclear 0.000260.00586&radic S000003893NMD5YJR132WverifiedKaryopherin, a carrier protein involved in nuclear import ofproteins; importin beta homolog 0.000260.00586&radic S000000895TSC11YER093CverifiedSubunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), amembrane-associated complex that regulatesactin cytoskeletal dynamics during polarizedgrowth and cell wall integrity; involved insphingolipid metabolism; contains a RasGEFNdomain 0.000260.00555 S000003831LIA1YJR070CverifiedDeoxyhypusine hydroxylase, a HEAT-repeat containingmetalloenzyme that catalyses hypusineformation; binds to and is required for themodification of Hyp2p (eIF5A); complements S.pombe mmd1 mutants defective in mitochondrialpositioning 0.000260.00555&radic S000004534POB3YML069WverifiedSubunit of the heterodimeric FACT complex (Spt16p-Pob3p), whichfacilitates RNA Polymerase II transcriptionelongation through nucleosomes by destabilizingand then reassembling nucleosome structure 0.000260.00555&radic S000005561SHE4YOR035CverifiedProtein containing a UCS (UNC-45/CRO1/SHE4) domain, binds tomyosin motor domains to regulate myosinfunction; involved in endocytosis, polarizationof the actin cytoskeleton, and asymmetric mRNAlocalization 0.000260.00555 S000001493UFD4YKL010CverifiedUbiquitin-protein ligase (E3) that interacts with Rpt4p andRpt6p, two subunits of the 19S particle of the26S proteasome; cytoplasmic E3 involved in thedegradation of ubiquitin fusion proteins 0.000260.00555&radic S000005571TOM6YOR045WverifiedComponent of the TOM (translocase of outer membrane) complexresponsible for recognition and initial importsteps for all mitochondrially directedproteins; promotes assembly and stability ofthe TOM complex 0.000260.00555 S000004312MMS22YLR320WverifiedProtein involved in resistance to ionizing radiation; acts withMms1p in a repair pathway that may be involvedin resolving replication intermediates orpreventing the damage caused by blockedreplication forks 0.000260.00549 S000006246PUF2YPR042CverifiedMember of the PUF protein family, which is defined by thepresence of Pumilio homology domains thatconfer RNA binding activity; preferentiallybinds mRNAs encoding membrane-associatedproteins 0.000260.00544 S000002221YDL063CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL063C is not an essential gene 0.000250.00521&radic S000005732NOC2YOR206WverifiedProtein that forms a nucleolar complex with Mak21p that bindsto 90S and 66S pre-ribosomes, as well as anuclear complex with Noc3p that binds to 66Spre-ribosomes; both complexes mediateintranuclear transport of ribosomal precursors 0.000250.00512&radic&radic S000004507RRN11YML043CverifiedProtein required for rDNA transcription by RNA polymerase I,component of the core factor (CF) of rDNAtranscription factor, which also contains Rrn6pand Rrn7p 0.000250.00512&radic S000003483YGR251WUncharacterizedPutative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene 0.000250.00489&radic&radic S000002428FAL1YDR021WverifiedNucleolar protein required for maturation of 18S rRNA, memberof the eIF4A subfamily of DEAD-boxATP-dependent RNA helicases 0.000250.00473&radic&radic S000005686MTR10YOR160WverifiedNuclear import receptor, mediates the nuclear localization ofproteins involved in mRNA-nucleus export 0.000240.00468&radic S000000609YCR016WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; YCR016W is not an essential gene 0.000240.00468&radic&radic S000002490RRP8YDR083WverifiedNucleolar protein involved in rRNA processing, pre-rRNAcleavage at site A2; also involved in telomeremaintenance; mutation is synthetically lethalwith a gar1 mutation 0.000240.0046&radic&radic S000003419HGH1YGR187CverifiedProtein of unknown function with similarity to human HMG1 andHMG2; localizes to the cytoplasm 0.000240.0046 S000001197RTT107YHR154WverifiedProtein implicated in Mms22-dependent DNA repair during Sphase, DNA damage induces phosphorylation byMec1p at one or more SQ/TQ motifs; interactswith Mms22p and Slx4p; has four BRCT domains;has a role in regulation of Ty1 transposition 0.000240.00455&radic&radic S000003824RPA12YJR063WverifiedRNA polymerase I subunit A12.2; contains two zinc bindingdomains, and the N terminal domain isresponsible for anchoring to the RNA pol Icomplex 0.000240.00455&radic S000000340MEC1YBR136WverifiedGenome integrity checkpoint protein and PI kinase superfamilymember; signal transducer required for cellcycle arrest and transcriptional responsesprompted by damaged or unreplicated DNA;monitors and participates in meioticrecombination 0.000240.00442 S000000065RFA1YAR007CverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 0.000240.00438&radic&radic S000006116APL5YPL195WverifiedDelta adaptin-like subunit of the clathrin associated proteincomplex (AP-3); functions in transport ofalkaline phosphatase to the vacuole via thealternate pathway, suppressor of loss of caseinkinase 1 function 0.000240.0043 S000003957RIX7YLL034CverifiedPutative ATPase of the AAA family, required for export ofpre-ribosomal large subunits from the nucleus;distributed between the nucleolus, nucleoplasm,and nuclear periphery depending on growthconditions 0.000240.00428&radic&radic S000001193PEX28YHR150WverifiedPeroxisomal integral membrane protein, involved in regulationof peroxisome size and number; geneticinteractions suggest that Pex28p and Pex29p actat steps upstream of those mediated by Pex30p,Pex31p, and Pex32p 0.000240.00428&radic S000006233APL4YPR029CverifiedGamma-adaptin, large subunit of the clathrin-associated protein(AP-1) complex; binds clathrin; involved invesicle mediated transport 0.000240.00428 S000001192SKG6YHR149CuncharacterizedProtein of unknown function; found in the bud tip and bud neck,potential Cdc28p substrate; Skg6p interactswith Zds1p and Zds2p 0.000240.00418&radic S000000274ALG14YBR070CverifiedComponent of UDP-GlcNAc transferase required for the secondstep of dolichyl-linked oligosaccharidesynthesis; anchors the catalytic subunit Alg13pto the ER membrane; similar to bacterial andhuman glycosyltransferases 0.000240.00418&radic S000003357YGR125WUncharacterizedPutative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole 0.000230.00406&radic S000001516YKL033WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YKL033W is an essential gene 0.000230.00406 S000003493APL6YGR261CverifiedBeta3-like subunit of the yeast AP-3 complex; functions intransport of alkaline phosphatase to thevacuole via the alternate pathway; exists inboth cytosolic and peripherally associatedmembrane-bound pools 0.000230.00406 S000003936PUF3YLL013CverifiedProtein that regulates degradation of specific mRNAs such asCOX17, binds almost exclusively to cytoplasmicmRNAs encoding mitochondrial proteins, memberof the PUF protein family that contains Pumiliohomology domains 0.000230.00403 S000005232CAF40YNL288WverifiedEvolutionarily conserved subunit of the CCR4-NOT complexinvolved in controlling mRNA initiation,elongation and degradation; binds Cdc39p 0.000230.00403 S000003802URB2YJR041CverifiedNucleolar protein required for normal metabolism of the rRNAprimary transcript, proposed to be involved inribosome biogenesis 0.000230.00392&radic S000005257YNL313CUncharacterizedProtein required for cell viability 0.000230.00385&radic&radic S000003992NOC3YLR002CverifiedProtein that forms a nuclear complex with Noc2p that binds to66S ribosomal precursors to mediate theirintranuclear transport; also binds to chromatinto promote the association of DNA replicationfactors and replication initiation 0.000230.00385&radic&radic S000005821UAF30YOR295WverifiedSubunit of UAF (upstream activation factor), which is an RNApolymerase I specific transcription stimulatoryfactor composed of Uaf30p, Rrn5p, Rrn9p,Rrn10p, histones H3 and H4; deletion decreasescellular growth rate 0.000230.00379&radic S000005527RRP6YOR001WverifiedExonuclease component of the nuclear exosome; contributes tothe quality-control system that retains anddegrades aberrant mRNAs in the nucleus 0.000230.00379&radic&radic S000005504NOP8YOL144WverifiedNucleolar protein required for 60S ribosomal subunit biogenesis 0.000230.0037&radic S000000130STU1YBL034CverifiedComponent of the mitotic spindle that binds to interpolarmicrotubules via its association withbeta-tubulin (Tub2p); required for interpolarmicrotubules to provide an outward force on thespindle poles 0.000230.0037 S000001196SPO16YHR153CverifiedProtein of unknown function, required for spore formation 0.000230.0037&radic S000000451ENP1YBR247CverifiedProtein associated with U3 and U14 snoRNAs, required forpre-rRNA processing and 40S ribosomal subunitsynthesis; localized in the nucleus andconcentrated in the nucleolus 0.000230.00363&radic&radic S000005868RPA190YOR341WverifiedRNA polymerase I subunit; largest subunit of RNA polymerase I 0.000220.00356&radic S000002577SEC7YDR170CverifiedGuanine nucleotide exchange factor (GEF) for ADP ribosylationfactors involved in proliferation of the Golgi,intra-Golgi transport and ER-to-Golgitransport; found in the cytoplasm and onGolgi-associated coated vesicles 0.000220.00356 S000000133APL3YBL037WverifiedAlpha-adaptin, large subunit of the clathrin associated proteincomplex (AP-2); involved in vesicle mediatedtransport 0.000220.00341 S000007223LUG1YCR087C-AuncharacterizedPutative protein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to thenucleolus; YCR087C-A is not an essential gene 0.000220.00341&radic S000005233PCL1YNL289WverifiedPho85 cyclin of the Pcl1,2-like subfamily, involved in entryinto the mitotic cell cycle and regulation ofmorphogenesis, localizes to sites of polarizedcell growth 0.000220.00338&radic S000005292NRM1YNR009WverifiedTranscriptional co-repressor of MBF (MCB bindingfactor)-regulated gene expression; Nrm1passociates stably with promoters via MBF torepress transcription upon exit from G1 phase 0.000220.00331&radic&radic S000003342YGR110WUncharacterizedPutative protein of unknown function; transcription is increased in response to genotoxic stress 0.000220.00331&radic S000005231SEC21YNL287WverifiedGamma subunit of coatomer, a heptameric protein complex thattogether with Arf1p forms the COPI coat;involved in ER to Golgi transport of selectivecargo 0.000220.00331 S000002915GIN4YDR507CverifiedProtein kinase involved in bud growth and assembly of theseptin ring, proposed to have kinase-dependentand kinase-independent activities; undergoesautophosphorylation; similar to Kcc4p and Hsl1p 0.000220.00331&radic S000000066SEN34YAR008WverifiedSubunit of the tRNA splicing endonuclease, which is composed ofSen2p, Sen15p, Sen34p, and Sen54p; Sen34pcontains the active site for tRNA 3' splicesite cleavage and has similarity to Sen2p andto Archaeal tRNA splicing endonuclease 0.000220.00328&radic S000000476HSM3YBR272CverifiedProtein of unknown function, involved in DNA mismatch repairduring slow growth; has weak similarity toMsh1p 0.000220.00324 S000001108SSF1YHR066WverifiedConstituent of 66S pre-ribosomal particles, required forribosomal large subunit maturation;functionally redundant with Ssf2p; member ofthe Brix family 0.000220.00324&radic&radic S000001005OTU2YHL013CverifiedProtein of unknown function that may interact with ribosomes,based on co-purification experiments; member ofthe ovarian tumor-like (OTU) superfamily ofpredicted cysteine proteases; shows cytoplasmiclocalization 0.000220.00323&radic S000002128SBH1YER087C-BverifiedBeta subunit of the Sec61p ER translocation complex(Sec61p-Sss1p-Sbh1p); involved in proteintranslocation into the endoplasmic reticulum;interacts with the exocyst complex; homologousto Sbh2p 0.000220.00323&radic S000006341RRP9YPR137WverifiedProtein involved in pre-rRNA processing, associated with U3snRNP; component of small ribosomal subunit(SSU) processosome; ortholog of the humanU3-55k protein 0.000220.00323&radic S000007236SNA2YDR525W-AverifiedProtein of unknown function, has similarity to Pmp3p, which isinvolved in cation transport; green fluorescentprotein (GFP)-fusion protein localizes to thecytoplasm in a punctate pattern 0.000220.00323&radic S000003732ELO1YJL196CverifiedElongase I, medium-chain acyl elongase, catalyzescarboxy-terminal elongation of unsaturatedC12-C16 fatty acyl-CoAs to C16-C18 fatty acids 0.000220.00323&radic S000002646SEC26YDR238CverifiedEssential beta-coat protein of the COPI coatomer, involved inER-to-Golgi protein trafficking and maintenanceof normal ER morphology; shares 43% sequenceidentity with mammalian beta-coat protein(beta-COP) 0.000220.00323 S000001279VID28YIL017CverifiedProtein involved in proteasome-dependent catabolite degradationof fructose-1,6-bisphosphatase (FBPase);localized to the nucleus and the cytoplasm 0.000210.00314&radic S000002637IVY1YDR229WverifiedPhospholipid-binding protein that interacts with both Ypt7p andVps33p, may partially counteract the action ofVps33p and vice versa, localizes to the rim ofthe vacuole as cells approach stationary phase 0.000210.0031&radic S000005057RPC19YNL113WverifiedRNA polymerase subunit, common to RNA polymerases I and III 0.000210.0031&radic S000004489YOX1YML027WverifiedHomeodomain-containing transcriptional repressor, binds toMcm1p and to early cell cycle boxes (ECBs) inthe promoters of cell cycle-regulated genesexpressed in M/G1 phase; expression is cellcycle-regulated; potential Cdc28p substrate 0.000210.0031&radic&radic S000003046DBP3YGL078CverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in ribosomal biogenesis 0.000210.00307&radic&radic S000000346MAK5YBR142WverifiedEssential nucleolar protein, putative DEAD-box RNA helicaserequired for maintenance of M1 dsRNA virus;involved in biogenesis of large (60S) ribosomalsubunits 0.000210.00307&radic&radic S000004523SML1YML058WverifiedRibonucleotide reductase inhibitor involved in regulating dNTPproduction; regulated by Mec1p and Rad53pduring DNA damage and S phase 0.000210.00307&radic S000003722MNN5YJL186WverifiedAlpha-1,2-mannosyltransferase, responsible for addition of thesecond alpha-1,2-linked mannose of the brancheson the mannan backbone of oligosaccharides,localizes to an early Golgi compartment 0.000210.00307&radic S000006324CLB5YPR120CverifiedB-type cyclin involved in DNA replication during S phase;activates Cdc28p to promote initiation of DNAsynthesis; functions in formation of mitoticspindles along with Clb3p and Clb4p; mostabundant during late G1 phase 0.000210.00307&radic S000001561DHR2YKL078WverifiedPredominantly nucleolar DEAH-box RNA helicase, required for 18SrRNA synthesis 0.000210.00305&radic S000003726RPS22AYJL190CverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps22Bp and has similarity to E.coli S8 and rat S15a ribosomal proteins 0.000210.00305&radic&radic S000001618APL2YKL135CverifiedBeta-adaptin, large subunit of the clathrin-associated protein(AP-1) complex; binds clathrin; involved inclathrin-dependent Golgi protein sorting 0.000210.00305 S000002636PCF11YDR228CverifiedmRNA 3' end processing factor, essential component of cleavageand polyadenylation factor IA (CF IA), involvedin pre-mRNA 3' end processing and intranscription termination; binds C-terminaldomain of largest subunit of RNA pol II(Rpo21p) 0.000210.00302&radic&radic S000004791SPT21YMR179WverifiedProtein required for normal transcription at several lociincluding HTA2-HTB2 and HHF2-HHT2, but notrequired at the other histone loci;functionally related to Spt10p; involved intelomere maintenance 0.000210.00302&radic&radic S000000049FLC2YAL053WverifiedPutative FAD transporter; required for uptake of FAD intoendoplasmic reticulum; involved in cell wallmaintenance 0.000210.00299 S000004568CUE4YML101CuncharacterizedProtein of unknown function; has a CUE domain that bindsubiquitin, which may facilitate intramolecularmonoubiquitination 0.000210.00298&radic S000003805VPS55YJR044CverifiedLate endosomal protein involved in late endosome to vacuoletrafficking; functional homolog of humanobesity receptor gene-related protein (OB-RGRP) 0.000210.00298&radic S000002820RRP17YDR412WuncharacterizedProtein required for cell viability 0.000210.00294&radic&radic S000005736RPB10YOR210WverifiedRNA polymerase subunit ABC10-beta, common to RNA polymerases I,II, and III 0.00020.00279&radic&radic S000001212DBP8YHR169WverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in biogenesis of the 40S ribosomalsubunit 0.00020.00271&radic&radic S000005005NOP2YNL061WverifiedProbable RNA m(5)C methyltransferase, essential for processingand maturation of 27S pre-rRNA and largeribosomal subunit biogenesis; localized to thenucleolus; constituent of 66S pre-ribosomalparticles 0.00020.00271&radic&radic S000001236EGD2YHR193CverifiedAlpha subunit of the heteromeric nascent polypeptide-associatedcomplex (NAC) involved in protein sorting andtranslocation, associated with cytoplasmicribosomes 0.00020.00268&radic S000000873YER071CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.00020.00268&radic S000001358YIL096CUncharacterizedPutative protein of unknown function; associates with precursors of the 60S ribosomal subunit 0.00020.00266&radic&radic S000001239UTP9YHR196WverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.00020.00266&radic S000001020WSC4YHL028WverifiedER membrane protein involved in the translocation of solublesecretory proteins and insertion of membraneproteins into the ER membrane; may also have arole in the stress response but has onlypartial functional overlap with WSC1-3 0.000190.00261 S000001385SIM1YIL123WverifiedProtein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that mayparticipate in DNA replication, promotercontains SCB regulation box at -300 bpindicating that expression may be cellcycle-regulated 0.000190.00255&radic S000004842RRP5YMR229CverifiedProtein required for the synthesis of both 18S and 5.8S rRNA;C-terminal region is crucial for the formationof 18S rRNA and N-terminal region is requiredfor the 5.8S rRNA; component of small ribosomalsubunit (SSU) processosome 0.000190.00255&radic S000002372NOP6YDL213CuncharacterizedProtein with similarity to hydrophilins, which are involved inthe adaptive response to hyperosmoticconditions; computational analysis oflarge-scale protein-protein interaction datasuggests a possible role in rRNA processing 0.000190.00253&radic S000005401NOP12YOL041CverifiedNucleolar protein, required for pre-25S rRNA processing;contains an RNA recognition motif (RRM) and hassimilarity to Nop13p, Nsr1p, and putativeorthologs in Drosophila and S. pombe 0.000190.00251&radic&radic S000004212UTP13YLR222CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.000190.00242&radic S000005837NOP58YOR310CverifiedProtein involved in pre-rRNA processing, 18S rRNA synthesis,and snoRNA synthesis; component of the smallsubunit processome complex, which is requiredfor processing of pre-18S rRNA 0.000190.00242&radic S000003612NET1YJL076WverifiedCore subunit of the RENT complex, which is a complex involvedin nucleolar silencing and telophase exit;stimulates transcription by RNA polymerase Iand regulates nucleolar structure 0.000190.00242&radic S000000808NUG1YER006WverifiedGTPase that associates with nuclear 60S pre-ribosomes, requiredfor export of 60S ribosomal subunits from thenucleus 0.000190.00242&radic&radic S000003562RRN7YJL025WverifiedProtein involved in the transcription of 35S rRNA genes by RNApolymerase I; component of the core factor (CF)complex also composed of Rrn11p, Rrn6p andTATA-binding protein 0.000190.00242&radic S000000110RRN6YBL014CverifiedProtein involved in the transcription of 35S rRNA genes by RNApolymerase I; component of the core factor (CF)complex also composed of Rrn11p, Rrn7p andTATA-binding protein 0.000180.00235&radic S000002218TSR1YDL060WverifiedProtein required for processing of 20S pre-rRNA in thecytoplasm, associates with pre-40S ribosomalparticles 0.000180.00235&radic S000005205ORC5YNL261WverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing 0.000180.00235&radic S000004539FPR3YML074CverifiedNucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506binding protein; phosphorylated by caseinkinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) anddephosphorylated by Ptp1p 0.000180.00235&radic&radic S000001800SRP40YKR092CverifiedNucleolar, serine-rich protein with a role in preribosomeassembly or transport; may function as achaperone of small nucleolar ribonucleoproteinparticles (snoRNPs); immunologically andstructurally to rat Nopp140 0.000180.00235&radic S000005321DBP6YNR038WverifiedEssential protein involved in ribosome biogenesis; putativeATP-dependent RNA helicase of the DEAD-boxprotein family 0.000180.00235&radic&radic S000000653PWP2YCR057CverifiedConserved 90S pre-ribosomal component essential for properendonucleolytic cleavage of the 35 S rRNAprecursor at A0, A1, and A2 sites; containseight WD-repeats; PWP2 deletion leads todefects in cell cycle and bud morphogenesis 0.000180.00235&radic S000002517FOB1YDR110WverifiedNucleolar protein required for DNA replication fork blockingand recombinational hotspot activities; bindsto the replication fork barrier site in therDNA region; related to retroviral integrases 0.000180.00233&radic S000004558UTP14YML093WverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.000180.00233&radic&radic S000002806UTP5YDR398WverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.000180.00233&radic S000001389YIL127CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus 0.000180.00231&radic S000004328SGD1YLR336CverifiedEssential nuclear protein with a possible role in theosmoregulatory glycerol response; interactswith phospholipase C (Plc1p); putative homologof human NOM1 which is implicated in acutemyeloid leukemia 0.000180.00231&radic S000001325YRB2YIL063CverifiedProtein of unknown function involved in nuclear processes ofthe Ran-GTPase cycle; involved in nuclearprotein export; contains Ran Binding Domain andFxFG repeats; interacts with Srm1p, GTP-Gsp1p,Rna1p and Crm1p; is not essential 0.000180.00231&radic S000004560RAD10YML095CverifiedSingle-stranded DNA endonuclease (with Rad1p), cleavessingle-stranded DNA during nucleotide excisionrepair and double-strand break repair; subunitof Nucleotide Excision Repair Factor 1 (NEF1);homolog of human ERCC1 protein 0.000180.00231&radic S000003307PRP38YGR075CverifiedUnique component of the U4/U6.U5 tri-snRNP particle,dispensable for spliceosome assembly, butrequired for conformational changes which leadto catalytic activation of the spliceosome 0.000180.00231&radic S000000345YBR141CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene 0.000180.00231&radic S000001441MPH1YIR002CverifiedMember of the DEAH family of helicases, functions in anerror-free DNA damage bypass pathway thatinvolves homologous recombination, mutationsconfer a mutator phenotype 0.000180.00229&radic S000004041FCF2YLR051CverifiedEssential nucleolar protein involved in the early steps of 35SrRNA processing; interacts with Faf1p; memberof a transcriptionally co-regulated set ofgenes called the RRB regulon 0.000180.00229&radic S000004211RSA3YLR221CverifiedProtein with a likely role in ribosomal maturation, requiredfor accumulation of wild-type levels of large(60S) ribosomal subunits; binds to the helicaseDbp6p in pre-60S ribosomal particles in thenucleolus 0.000180.00229&radic S000005252KRI1YNL308CverifiedEssential nucleolar protein required for 40S ribosomebiogenesis; physically and functionallyinteracts with Krr1p 0.000180.00226&radic S000002287YDL129WUncharacterizedHypothetical protein 0.000180.00226&radic S000005564HIR2YOR038CverifiedNon-essential transcriptional corepressor involved in the cellcycle-regulated transcription of histone H2A,H2B, H3, and H4 genes; recruits Swi-Snfcomplexes to histone gene promoters; promotesheterochromatic gene silencing with Asf1p 0.000180.00226&radic S000001185RPC10YHR143W-AverifiedRNA polymerase subunit, found in RNA polymerase complexes I,II, and III 0.000180.00226&radic S000005985CWC27YPL064CverifiedComponent of a complex containing Cef1p, putatively involved inpre-mRNA splicing; has similarity to S. pombeCwf27p 0.000180.00226&radic S000004564TAF13YML098WverifiedTFIID subunit (19 kDa), involved in RNA polymerase IItranscription initiation, similar to histone H4with atypical histone fold motif of Spt3-liketranscription factors 0.000180.00226&radic S000005902GDH1YOR375CverifiedNADP(+)-dependent glutamate dehydrogenase, synthesizesglutamate from ammonia and alpha-ketoglutarate;rate of alpha-ketoglutarate utilization differsfrom Gdh3p; expression regulated by nitrogenand carbon sources 0.000180.00226&radic S000005192RPA49YNL248CverifiedRNA polymerase I subunit A49 0.000180.00226&radic S000004806MRPL24YMR193WverifiedMitochondrial ribosomal protein of the large subunit 0.000180.00226&radic S000000115APN2YBL019WverifiedClass II abasic (AP) endonuclease involved in repair of DNAdamage; homolog of human HAP1 and E. coliexoIII 0.000180.00226&radic S000005657YOR131CUncharacterizedHypothetical protein 0.000180.00226&radic S000004699UTP15YMR093WverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.000180.00226&radic&radic S000005287YNR004WUncharacterizedHypothetical protein 0.000180.00226&radic S000005639AZF1YOR113WverifiedZinc-finger transcription factor, involved in induction of CLN3transcription in response to glucose; geneticand physical interactions indicate a possiblerole in mitochondrial transcription or genomemaintenance 0.000170.00224&radic S000002736SKP1YDR328CverifiedEvolutionarily conserved kinetochore protein that is part ofmultiple protein complexes, including the SCFubiquitin ligase complex, the CBF3 complex thatbinds centromeric DNA, and the RAVE complexthat regulates assembly of the V-ATPase 0.000170.00224&radic S000001206SOL3YHR163Wverified6-phosphogluconolactonase, catalyzes the second step of thepentose phosphate pathway; weak multicopysuppressor of los1-1 mutation; homologous toSol2p and Sol1p 0.000170.00224&radic S000003280UFD1YGR048WverifiedProtein that interacts with Cdc48p and Npl4p, involved inrecognition of polyubiquitinated proteins andtheir presentation to the 26S proteasome fordegradation; involved in transporting proteinsfrom the ER to the cytosol 0.000170.00224&radic S000005496PFK27YOL136Cverified6-phosphofructo-2-kinase, catalyzes synthesis offructose-2,6-bisphosphate; inhibited byphosphoenolpyruvate and sn-glycerol3-phosphate, expression induced by glucose andsucrose, transcriptional regulation involvesprotein kinase A 0.000170.00224&radic S000000842GLN3YER040WverifiedTranscriptional activator of genes regulated by nitrogencatabolite repression (NCR), localization andactivity regulated by quality of nitrogensource 0.000170.00224&radic S000002688RRP45YDR280WverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex 0.000170.00224&radic&radic S000001794PRP16YKR086WverifiedRNA helicase in the DEAH-box family involved in the secondcatalytic step of splicing, exhibitsATP-dependent RNA unwinding activity 0.000170.00223&radic S000002981PDR1YGL013CverifiedZinc cluster protein that is a master regulator involved inrecruiting other zinc cluster proteins topleiotropic drug response elements (PDREs) tofine tune the regulation of multidrugresistance genes 0.000170.00223&radic S000005889PRE10YOR362Cverified20S proteasome alpha-type subunit 0.000170.00223&radic S000002997CGR1YGL029WverifiedProtein involved in nucleolar integrity and processing of thepre-rRNA for the 60S ribosome subunit;transcript is induced in response to cytotoxicstress but not genotoxic stress 0.000170.00223&radic S000006331YPR127WUncharacterizedHypothetical protein 0.000170.00223&radic S000002583NGG1YDR176WverifiedTranscriptional regulator involved in glucose repression ofGal4p-regulated genes; component oftranscriptional adaptor and histoneacetyltransferase complexes, the ADA complex,the SAGA complex, and the SLIK complex 0.000170.00223&radic S000003169MCM6YGL201CverifiedProtein involved in DNA replication; component of the Mcm2-7hexameric complex that binds chromatin as apart of the pre-replicative complex 0.000170.0022&radic S000001569SRX1YKL086WverifiedSulfiredoxin, contributes to oxidative stress resistance byreducing cysteine-sulfinic acid groups in theperoxiredoxins Tsa1p and Ahp1p that are formedupon exposure to oxidants; conserved in highereukaryotes 0.000170.0022&radic S000001497URB1YKL014CverifiedNucleolar protein required for the normal accumulation of 25Sand 5.8S rRNAs, associated with the 27SA2pre-ribosomal particle; proposed to be involvedin the biogenesis of the 60S ribosomal subunit 0.000170.0022&radic S000003437YGR205WVerifiedATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases 0.000170.0022&radic S000002232BRE1YDL074CverifiedE3 ubiquitin ligase for Rad6p, required for the ubiquitinationof histone H2B, recruitment of Rad6p topromoter chromatin and subsequent methylationof histone H3 (on L4 and L79), contains RINGfinger domain 0.000170.0022&radic S000004883RRN9YMR270CverifiedProtein involved in promoting high level transcription of rDNA,subunit of UAF (upstream activation factor) forRNA polymerase I 0.000170.0022&radic S000006264ARO7YPR060CverifiedChorismate mutase, catalyzes the conversion of chorismate toprephenate to initiate thetyrosine/phenylalanine-specific branch ofaromatic amino acid biosynthesis 0.000170.0022&radic S000002773ESF1YDR365CverifiedNucleolar protein involved in pre-rRNA processing; depletioncauses severely decreased 18S rRNA levels 0.000170.0022&radic&radic S000002451HEM13YDR044WverifiedCoproporphyrinogen III oxidase, an oxygen requiring enzyme thatcatalyzes the sixth step in the hemebiosynthetic pathway; localizes to themitochondrial inner membrane; transcription isrepressed by oxygen and heme (via Rox1p andHap1p) 0.000170.0022&radic S000005996GCR1YPL075WverifiedTranscriptional activator of genes involved in glycolysis;DNA-binding protein that interacts andfunctions with the transcriptional activatorGcr2p 0.000170.0022&radic S000000121RRN10YBL025WverifiedProtein involved in promoting high level transcription of rDNA,subunit of UAF (upstream activation factor) forRNA polymerase I 0.000170.00218&radic S000002294RDI1YDL135CverifiedRho GDP dissociation inhibitor involved in the localization andregulation of Cdc42p 0.000170.00218&radic S000000356SPP381YBR152WverifiedmRNA splicing factor, component of U4/U6.U5 tri-snRNP;interacts genetically and physically withPrp38p 0.000170.00218&radic S000003059NBP35YGL091CverifiedEssential P-loop NTPase that functions in nuclear and cytosoliciron-sulfur (FeS) protein assembly; has ahighly conserved N-terminus 0.000170.00218&radic S000004034PDC1YLR044CverifiedMajor of three pyruvate decarboxylase isozymes, key enzyme inalcoholic fermentation, decarboxylates pyruvateto acetaldehyde; subject to glucose-, ethanol-,and autoregulation; involved in amino acidcatabolism 0.000170.00218&radic S000001849SEC53YFL045CverifiedPhosphomannomutase, involved in synthesis of GDP-mannose anddolichol-phosphate-mannose; required forfolding and glycosylation of secretory proteinsin the ER lumen 0.000170.00218&radic S000000097ECM15YBL001CverifiedNon-essential protein of unknown function, likely exists astetramer, may be regulated by the binding ofsmall-molecule ligands (possibly sulfate ions),may have a role in yeast cell-wall biogenesis 0.000170.00217&radic S000003119NUT1YGL151WverifiedComponent of the RNA polymerase II mediator complex, which isrequired for transcriptional activation andalso has a role in basal transcription 0.000170.00217&radic S000002367NHP2YDL208WverifiedNuclear protein related to mammalian high mobility group (HMG)proteins, essential for function of H/ACA-typesnoRNPs, which are involved in 18S rRNAprocessing 0.000170.00217&radic S000001308MET30YIL046WverifiedF-box protein containing five copies of the WD40 motif,controls cell cycle function, sulfurmetabolism, and methionine biosynthesis as partof the ubiquitin ligase complex; interacts withand regulates Met4p, localizes within thenucleus 0.000170.00217&radic S000004169YLR179CUncharacterizedProtein of unknown function, transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus; YLR179C is not essential 0.000170.00217&radic S000002433YDR026CUncharacterizedPutative transcription factor; Myb-like DNA-binding protein that may bind to the Ter region of rDNA; interacts physically with Fob1p, although this interaction is not involved in replication fork arrest 0.000170.00215&radic S000002480SNF11YDR073WverifiedSubunit of the SWI/SNF chromatin remodeling complex involved intranscriptional regulation; interacts with ahighly conserved 40-residue sequence of Snf2p 0.000170.00215&radic S000003240STF2YGR008CverifiedProtein involved in regulation of the mitochondrial F1F0-ATPsynthase; Stf1p and Stf2p act as stabilizingfactors that enhance inhibitory action of theInh1p protein 0.000170.00215&radic S000001454RPR2YIR015WverifiedSubunit of nuclear RNase P, which cleaves tRNA precursors togenerate mature 5' ends; not shared betweenRNase MRP and RNase P, in contrast to all otherRNase P protein subunits 0.000170.00215&radic S000005769PUS7YOR243CverifiedPseudouridine synthase, catalyzes pseudouridylation at position35 in U2 snRNA, position 13 in cytoplasmictRNAs, and position 35 in pre-tRNA(Tyr);Asp(256) mutation abolishes activity; conservedin archaea, some bacteria, and vertebrates 0.000170.00215&radic S000001244PPX1YHR201CverifiedExopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P)into Pi residues; located in the cytosol,plasma membrane, and mitochondrial matrix 0.000170.00215&radic S000003515YGR283CUncharacterizedPutative protein of unknown function; deletion mutant is resistant to fluconazole; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus 0.000170.00214&radic S000003435YGR203WUncharacterizedPutative protein with sequence similarity to protein tyrosine phosphatases of the CDC25-like phosphatase family; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 0.000170.00214&radic S000003177MIG2YGL209WverifiedProtein containing zinc fingers, involved in repression, alongwith Mig1p, of SUC2 (invertase) expression byhigh levels of glucose; binds to Mig1p-bindingsites in SUC2 promoter 0.000170.00213&radic S000000215IPP1YBR011CverifiedCytoplasmic inorganic pyrophosphatase (PPase), catalyzes therapid exchange of oxygens from Pi with water,highly expressed and essential for viability,active-site residues show identity to thosefrom E. coli PPase 0.000170.00213&radic S000001508PAN3YKL025CverifiedEssential subunit of the Pan2p-Pan3p poly(A)-ribonucleasecomplex, which acts to control poly(A) taillength and regulate the stoichiometry andactivity of postreplication repair complexes 0.000160.00212 S000004042IES3YLR052WverifiedSubunit of the INO80 chromatin remodeling complex 0.000160.00212&radic S000002580ARG82YDR173CverifiedInositol polyphosphate multikinase (IPMK), sequentiallyphosphorylates Ins(1,4,5)P3 to formIns(1,3,4,5,6)P5; putative nuclear lipidinositol PI3-kinase; regulates arginine-,phosphate-, and nitrogen-responsive genes 0.000160.00212&radic S000006010RLM1YPL089CverifiedMADS-box transcription factor, component of the protein kinaseC-mediated MAP kinase pathway involved in themaintenance of cell integrity; phosphorylatedand activated by the MAP-kinase Slt2p 0.000160.00212&radic S000004218ECM22YLR228CverifiedSterol regulatory element binding protein, regulatestranscription of the sterol biosynthetic genesERG2 and ERG3; member of the fungus-specificZn[2]-Cys[6] binuclear cluster family oftranscription factors; homologous to Upc2p 0.000160.00212&radic S000000647YCR051WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene 0.000160.00212&radic S000003201TAN1YGL232WverifiedPutative tRNA acetyltransferase, RNA-binding protein requiredfor the formation of the modified nucleosideN(4)-acetylcytidine in serine and leucine tRNAsbut not required for the same modification in18S rRNA 0.000160.00212&radic S000006391RPO26YPR187WverifiedRNA polymerase subunit ABC23, common to RNA polymerases I, II,and III; part of central core; similar tobacterial omega subunit 0.000160.00211&radic S000006214RPA135YPR010CverifiedRNA polymerase I subunit A135 0.000160.00211&radic S000004107CLF1YLR117CverifiedEssential splicesome assembly factor; contains multipletetratricopeptide repeat (TPR) protein-bindingmotifs and interacts specifically with manyspliceosome components, may serve as a scaffoldduring splicesome assembly 0.000160.00211&radic S000003618IML2YJL082WverifiedProtein of unknown function; the authentic, non-tagged proteinis detected in highly purified mitochondria inhigh-throughput studies 0.000160.00211&radic S000003769TDH2YJR009CverifiedGlyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involvedin glycolysis and gluconeogenesis; tetramerthat catalyzes the reaction ofglyceraldehyde-3-phosphate to 1,3bis-phosphoglycerate; detected in the cytoplasmand cell-wall 0.000160.00211&radic S000004443LEU3YLR451WverifiedZinc-finger transcription factor that regulates genes involvedin branched chain amino acid biosynthesis andammonia assimilation; positively regulated byalpha-isopropylmalate, an intermediate inleucine biosynthesis 0.000160.00211&radic S000004565ARG81YML099CverifiedZinc-finger transcription factor of the Zn(2)-Cys(6) binuclearcluster domain type, involved in the regulationof arginine-responsive genes; acts with Arg80pand Arg82p 0.000160.00211&radic S000002349UFD2YDL190CverifiedUbiquitin chain assembly factor (E4) that cooperates with aubiquitin-activating enzyme (E1), aubiquitin-conjugating enzyme (E2), and aubiquitin protein ligase (E3) to conjugateubiquitin to substrates; also functions as an 0.000160.00211&radic S000006277LTP1YPR073CverifiedProtein phosphotyrosine phosphatase of unknown cellular role;activated by adenine 0.000160.00209&radic S000001884WWM1YFL010CverifiedWW domain containing protein of unknown function; binds toMca1p, a caspase-related protease thatregulates H2O2-induced apoptosis;overexpression causes Gi phase growth arrestand clonal death that is suppressed byoverexpression of MCA1 0.000160.00209&radic S000002510STE5YDR103WverifiedPheromone-responsive scaffold protein; shuttles from thenucleus to the plasma membrane and assembleskinases Ste11p, Ste7p, and Fus3p into aspecific signaling complex; active oligomericform interacts with Ste4p-Ste18p complex 0.000160.00209&radic S000004237IRC20YLR247CuncharacterizedPutative helicase; localized to mitochondria and the nucleus;YLR247C is not an essential gene; null mutantdisplays increased levels of spontaneous Rad52foci 0.000160.00209&radic S000001649TPK3YKL166CverifiedSubunit of cAMP-dependent protein kinase, which contains Tpk1p,Tpk2p, Tpk3p, and regulatory subunit Bcy1p;promotes growth in response to nutrients;mediates induction of apoptosis due toactin-mediated hyperactivation of Ras signaling 0.000160.00209&radic S000001179ARO9YHR137WverifiedAromatic aminotransferase, catalyzes the first step oftryptophan, phenylalanine, and tyrosinecatabolism 0.000160.00209&radic S000003038RPB9YGL070CverifiedRNA polymerase II subunit B12.6; contacts DNA; mutations affecttranscription start site; involved in telomeremaintenance 0.000160.00209&radic S000006249MNI2YPR045CuncharacterizedDeletion mutant is synthetically lethal with MEN mutants 0.000160.00209&radic S000004987BOP3YNL042WverifiedProtein of unknown function, potential Cdc28p substrate;overproduction suppresses a pam1 slv3 doublenull mutation and confers resistance tomethylmercury 0.000160.00209&radic S000002907LCD1YDR499WverifiedEssential protein required for the DNA integrity checkpointpathways; interacts physically with Mec1p;putative homolog of S. pombe Rad26 and humanATRIP 0.000160.00209&radic S000002888DIG2YDR480WverifiedRegulatory protein of unknown function, pheromone-inducible,involved in the regulation of mating-specificgenes and the invasive growth pathway, requiredfor MAP-kinase imposed repression, inhibitspheromone-responsive transcription 0.000160.00209&radic S000003123CDC43YGL155WverifiedBeta subunit of geranylgeranyltransferase type I, catalyzesgeranylgeranylation to the cysteine residue inproteins containing a C-terminal CaaX sequenceending in Leu or Phe; has substrates importantfor morphogenesis 0.000160.00209&radic S000000840KRE29YER038CverifiedEssential subunit of the Mms21-Smc5-Smc6 complex; protein ofunknown function; required for growth and DNArepair; heterozygous mutant showshaploinsufficiency in K1 killer toxinresistance 0.000160.00209&radic S000002368CWC2YDL209CverifiedProtein involved in pre-mRNA splicing, component of a complexcontaining Cef1p; interacts with Prp19p;contains an RNA recognition motif; hassimilarity to S. pombe Cwf2p 0.000160.00209&radic S000004135RMP1YLR145WverifiedEssential component of RNase MRP, which processes pre-rRNA inthe nucleolus and also processes mitochondrialRNAs to create RNA primers for DNA replication 0.000160.00209&radic S000002977LEU1YGL009CverifiedIsopropylmalate isomerase, catalyzes the second step in theleucine biosynthesis pathway 0.000160.00207&radic S000005795PAC1YOR269WverifiedProtein involved in nuclear migration, part of thedynein/dynactin pathway; targets dynein tomicrotubule tips, which is necessary forsliding of microtubules along bud cortex;synthetic lethal with bni1; homolog of humanLIS1 0.000160.00207&radic S000003778ESS1YJR017CverifiedPeptidylprolyl-cis/trans-isomerase (PPIase) specific forphosphorylated serine and threonine residuesN-terminal to proline; regulatesphosphorylation of the RNA polymerase II largesubunit (Rpo21p) C-terminal domain 0.000160.00207&radic S000005159IES2YNL215WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.000160.00207&radic S000002948IRC4YDR540CuncharacterizedHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 0.000160.00207&radic S000000187MAP2YBL091CverifiedMethionine aminopeptidase, catalyzes the cotranslationalremoval of N-terminal methionine from nascentpolypeptides; function is partially redundantwith that of Map1p 0.000160.00207&radic S000001881IES1YFL013CverifiedSubunit of the INO80 chromatin remodeling complex 0.000160.00207&radic S000000611SRD1YCR018CverifiedProtein involved in the processing of pre-rRNA to mature rRNA;contains a C2/C2 zinc finger motif; srd1mutation suppresses defects caused by therrp1-1 mutation 0.000160.00207&radic S000001384POG1YIL122WverifiedPutative transcriptional activator that promotes recovery frompheromone induced arrest; inhibits bothalpha-factor induced G1 arrest and repressionof CLN1 and CLN2 via SCB/MCB promoter elements;potential Cdc28p substrate; SBF regulated 0.000160.00207&radic S000001169YHR127WVerifiedProtein of unknown function; localizes to the nucleus 0.000160.00207&radic S000005885HAP5YOR358WverifiedSubunit of the heme-activated, glucose-repressed Hap2/3/4/5CCAAT-binding complex, a transcriptionalactivator and global regulator of respiratorygene expression; required for assembly and DNAbinding activity of the complex 0.000160.00207&radic S000001381RPI1YIL119CverifiedPutative transcriptional regulator; overexpression suppressesthe heat shock sensitivity of wild-type RAS2overexpression and also suppresses the celllysis defect of an mpk1 mutation 0.000160.00207&radic S000003730CDC6YJL194WverifiedEssential ATP-binding protein required for DNA replication,component of the pre-replicative complex(pre-RC) which requires ORC to associate withchromatin and is in turn required for Mcm2-7pDNA association; homologous to S. pombe Cdc18p 0.000160.00207&radic&radic S000002994TRP5YGL026CverifiedTryptophan synthase involved in tryptophan biosynthesis,regulated by the general control system ofamino acid biosynthesis 0.000160.00206&radic S000001083SRB2YHR041CverifiedGeneral transcription factor, subunit of the RNA polymerase IImediator complex; associates with corepolymerase subunits to form the RNA polymeraseII holoenzyme; involved in telomere maintenance 0.000160.00206&radic S000005047MET4YNL103WverifiedLecine-zipper transcriptional activator, responsible for theregulation of the sulfur amino acid pathway,requires different combinations of theauxiliary factors Cbf1p, Met28p, Met31p andMet32p 0.000160.00206&radic S000001541TOA2YKL058WverifiedTFIIA small subunit; involved in transcriptional activation,acts as antirepressor or as coactivator;homologous to smallest subunit of human andDrosophila TFIIA 0.000160.00206&radic S000000804NOP16YER002WverifiedConstituent of 66S pre-ribosomal particles, involved in 60Sribosomal subunit biogenesis 0.000160.00206&radic&radic S000001946PRE4YFR050Cverified20S proteasome beta-type subunit 0.000160.00206&radic S000006226YPR022CUncharacterizedHypothetical protein 0.000160.00206&radic S000004124PDC5YLR134WverifiedMinor isoform of pyruvate decarboxylase, key enzyme inalcoholic fermentation, decarboxylates pyruvateto acetaldehyde, regulation is glucose- andethanol-dependent, repressed by thiamine,involved in amino acid catabolism 0.000160.00202&radic S000002881PRP3YDR473CverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.000160.00202&radic S000004595ERG13YML126Cverified3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzesthe formation of HMG-CoA from acetyl-CoA andacetoacetyl-CoA; involved in the second step inmevalonate biosynthesis 0.000160.00202&radic S000004840TAF7YMR227CverifiedTFIID subunit (67 kDa), involved in RNA polymerase IItranscription initiation 0.000160.00202&radic S000002835RPN9YDR427WverifiedNon-ATPase regulatory subunit of the 26S proteasome, hassimilarity to putative proteasomal subunits inother species; null mutant is temperaturesensitive and exhibits cell cycle andproteasome assembly defects 0.000160.00202&radic S000001270URM1YIL008WverifiedUbiquitin-like protein with only weak sequence similarity toubiquitin; depends on the E1-like activatingenzyme Uba4p; molecular function of the Urm1ppathway is unknown, but it is required fornormal growth, particularly at high temperature 0.000160.00202&radic S000004570CAC2YML102WverifiedComponent of the chromatin assembly complex (with Rlf2p andMsi1p) that assembles newly synthesizedhistones onto recently replicated DNA, requiredfor building functional kinetochores, conservedfrom yeast to humans 0.000160.00202&radic S000000493SNF5YBR289WverifiedSubunit of the SWI/SNF chromatin remodeling complex involved intranscriptional regulation; functionsinterdependently in transcriptional activationwith Snf2p and Snf6p 0.000160.00202&radic S000002459DBF4YDR052CverifiedRegulatory subunit of Cdc7p-Dbf4p kinase complex, required forCdc7p kinase activity and initiation of DNAreplication; phosphorylates the Mcm2-7 familyof proteins; cell cycle regulated 0.000160.00202&radic S000001909IOC3YFR013WverifiedMember of a complex (Isw1a) with Isw1p that hasnucleosome-stimulated ATPase activity andrepresses transcription initiation by specificpositioning of a promoter proximaldinucleosome; has homology to Esc8p, which isinvolved in silencing 0.000160.00202&radic S000004319TMA10YLR327CverifiedProtein of unknown function that associates with ribosomes 0.000160.00202&radic S000005976LGE1YPL055CverifiedProtein of unknown function; null mutant forms abnormally largecells 0.000160.00202&radic S000001448MSL1YIR009WverifiedU2B component of U2 snRNP, involved in splicing, binds the U2snRNA stem-loop IV in vitro; does not containthe conserved C-terminal RNA binding domainfound in other family members 0.000160.00202&radic S000005890PIP2YOR363CverifiedAutoregulatory oleate-specific transcriptional activator ofperoxisome proliferation, contains Zn(2)-Cys(6)cluster domain, forms heterodimer with Oaf1p,binds oleate response elements (OREs),activates beta-oxidation genes 0.000160.00202&radic S000003676RPB4YJL140W