Yfunc lets you browse current and predicted gene functions in yeast

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Prediction of GO:0007242 "intracellular signaling cascade"

GO branch: BP
Number of currently annotated genes: 116

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest Huh:cytoplasmIPR003578Lum:5-FUIPR003577Lum:DiltiazemKumar:cell peripheryLum:TroglitazoneLum:Sodium ChlorideHuh:budLum:Sulfamethoxazole S000004219CDC42YLR229CverifiedSmall rho-like GTPase, essential for establishment andmaintenance of cell polarity; mutants havedefects in the organization of actin andseptins &radic0.741980.93983&radic S000006369RHO1YPR165WverifiedGTP-binding protein of the rho subfamily of Ras-like proteins,involved in establishment of cell polarity;regulates protein kinase C (Pkc1p) and the cellwall synthesizing enzyme 1,3-beta-glucansynthase (Fks1p and Gsc2p) &radic0.749120.93975&radic&radic&radic&radic S000005635INP53YOR109WverifiedPhosphatidylinositol 4,5-bisphosphate 5-phosphatase,synaptojanin-like protein with an N-terminalSac1 domain, plays a role in a TGN (trans Golginetwork)-to-early endosome pathway;hyperosmotic stress causes translocation toactin patches &radic0.731030.93455&radic&radic S000005042RAS2YNL098CverifiedGTP-binding protein that regulates the nitrogen starvationresponse, sporulation, and filamentous growth;farnesylation and palmitoylation required foractivity and localization to plasma membrane;homolog of mammalian Ras proto-oncogenes &radic0.703980.92484&radic&radic&radic S000001264INP51YIL002CverifiedPhosphatidylinositol 4,5-bisphosphate 5-phosphatase,synaptojanin-like protein with an N-terminalSac1 domain, plays a role inphosphatidylinositol 4,5-bisphosphatehomeostasis and in endocytosis; null mutationconfers cold-tolerant growth &radic0.70210.92372&radic&radic&radic S000000464RGD1YBR260CverifiedGTPase-activating protein (RhoGAP) for Rho3p and Rho4p,possibly involved in control of actincytoskeleton organization 0.695120.92105&radic&radic&radic&radic&radic S000000022LTE1YAL024CverifiedPutative GDP/GTP exchange factor required for mitotic exit atlow temperatures; acts as a guanine nucleotideexchange factor (GEF) for Tem1p, which is a keyregulator of mitotic exit; physicallyassociates with Ras2p-GTP 0.67580.91626&radic S000005441IRA2YOL081WverifiedGTPase-activating protein that negatively regulates RAS byconverting it from the GTP- to the GDP-boundinactive form, required for reducing cAMPlevels under nutrient limiting conditions, hassimilarity to Ira1p and human neurofibromin &radic0.672130.91216&radic&radic&radic S000005653RGA1YOR127WverifiedGTPase-activating protein for the polarity-establishmentprotein Cdc42p; implicated in control of septinorganization, pheromone response, and haploidinvasive growth &radic0.669570.91119&radic S000006036BEM3YPL115CverifiedRho GTPase activating protein (RhoGAP) involved in control ofthe cytoskeleton organization; targets theessential Rho-GTPase Cdc42p, which controlsestablishment and maintenance of cell polarity,including bud-site assembly &radic0.665930.91065&radic&radic&radic&radic S000001380RHO3YIL118WverifiedNon-essential small GTPase of the Rho/Rac subfamily of Ras-likeproteins involved in the establishment of cellpolarity; GTPase activity positively regulatedby the GTPase activating protein (GAP) Rgd1p &radic0.663090.90985&radic S000000957BEM2YER155CverifiedRho GTPase activating protein (RhoGAP) involved in the controlof cytoskeleton organization and cellularmorphogenesis; required for bud emergence &radic0.656010.90823&radic S000005534SLG1YOR008CverifiedSensor-transducer of the stress-activated PKC1-MPK1 kinasepathway involved in maintenance of cell wallintegrity; involved in organization of theactin cytoskeleton; secretory pathway Wsc1p isrequired for the arrest of secretion response &radic0.651110.90095&radic&radic&radic S000004296STT4YLR305CverifiedPhosphatidylinositol-4-kinase that functions in the Pkc1pprotein kinase pathway; required for normalvacuole morphology, cell wall integrity, andactin cytoskeleton organization &radic0.63730.89394&radic&radic&radic S000005050INP52YNL106CverifiedPhosphatidylinositol 4,5-bisphosphate 5-phosphatase,synaptojanin-like protein with an N-terminalSac1 domain, plays a role in endocytosis;hyperosmotic stress causes translocation toactin patches &radic0.634720.89192 S000000999STE20YHL007CverifiedSignal transducing kinase of the PAK (p21-activated kinase)family, involved in pheromone response andpseudohyphal/invasive growth pathways,activated by Cdc42p; binds Ste4p at a GBB motifpresent in noncatalytic domains of PAK kinases 0.634320.88939&radic&radic&radic&radic S000004354STE11YLR362WverifiedSignal transducing MEK kinase involved in pheromone responseand pseudohyphal/invasive growth pathways whereit phosphorylates Ste7p, and the highosmolarity response pathway, viaphosphorylation of Pbs2p; regulated by Ste20pand Ste50p 0.62840.88734&radic&radic&radic S000002399LRG1YDL240WverifiedPutative GTPase-activating protein (GAP) involved in thePkc1p-mediated signaling pathway that controlscell wall integrity; appears to specificallyregulate 1,3-beta-glucan synthesis &radic0.624440.88451&radic S000005627RAS1YOR101WverifiedGTPase involved in G-protein signaling in the adenylate cyclaseactivating pathway, plays a role in cellproliferation; localized to the plasmamembrane; homolog of mammalian RASproto-oncogenes &radic0.623990.88449&radic&radic&radic&radic S000002797SAC7YDR389WverifiedGTPase activating protein (GAP) for Rho1p, involved insignaling to the actin cytoskeleton, nullmutations suppress tor2 mutations andtemperature sensitive mutations in actin;potential Cdc28p substrate &radic0.606480.87744&radic&radic&radic&radic&radic S000001763RHO4YKR055WverifiedNon-essential small GTPase of the Rho/Rac subfamily of Ras-likeproteins, likely to be involved in theestablishment of cell polarity &radic0.599940.87253&radic&radic&radic S000004301CDC25YLR310CverifiedMembrane bound guanine nucleotide exchange factor (GEF orGDP-release factor); indirectly regulatesadenylate cyclase through activation of Ras1pand Ras2p by stimulating the exchange of GDPfor GTP; required for progression through G1 &radic0.594690.86721&radic&radic&radic&radic S000000344IRA1YBR140CverifiedGTPase-activating protein that negatively regulates RAS byconverting it from the GTP- to the GDP-boundinactive form, required for reducing cAMPlevels under nutrient limiting conditions,mediates membrane association of adenylatecyclase &radic0.592530.86721&radic S000001686TOR2YKL203CverifiedPIK-related protein kinase and rapamycin target; subunit ofTORC1, a complex that regulates growth inresponse to nutrients and TORC2, a complex thatregulates cell-cycle dependent polarization ofthe actin cytoskeleton; involved in meiosis &radic0.581940.86145&radic&radic&radic S000005242CLA4YNL298WverifiedCdc42p activated signal transducing kinase of the PAK(p21-activated kinase) family, involved inseptin ring assembly and cytokinesis; directlyphosphorylates septins Cdc3p and Cdc10p; otheryeast PAK family members are Ste20p and Skm1p &radic0.579430.86106&radic&radic&radic&radic S000005034RHO2YNL090WverifiedNon-essential small GTPase of the Rho/Rac subfamily of Ras-likeproteins, involved in the establishment of cellpolarity and in microtubule assembly &radic0.576630.8584&radic&radic S000005465WSC3YOL105CverifiedPartially redundant sensor-transducer of the stress-activatedPKC1-MPK1 signaling pathway involved inmaintenance of cell wall integrity; involved inthe response to heat shock and other stressors;regulates 1,3-beta-glucan synthesis &radic0.570330.85453 S000003384RSR1YGR152CverifiedGTP-binding protein of the ras superfamily required for budsite selection, morphological changes inresponse to mating pheromone, and efficientcell fusion; localized to the plasma membrane;significantly similar to mammalian Rap GTPases &radic0.56960.85453&radic&radic&radic&radic S000000979BMH1YER177Wverified14-3-3 protein, major isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others &radic0.568110.8544&radic S000003944SPA2YLL021WverifiedComponent of the polarisome, which functions in actincytoskeletal organization during polarizedgrowth; acts as a scaffold for Mkk1p and Mpk1pcell wall integrity signaling components;potential Cdc28p substrate &radic0.564460.84904&radic&radic&radic&radic S000000039CDC24YAL041WverifiedGuanine nucleotide exchange factor (GEF or GDP-release factor)for Cdc42p; required for polarity establishmentand maintenance, and mutants have morphologicaldefects in bud formation and shmooing &radic0.563650.84902&radic&radic&radic S000004417TUS1YLR425WverifiedGuanine nucleotide exchange factor (GEF) that functions tomodulate Rho1p activity as part of the cellintegrity signaling pathway; multicopysuppressor of tor2 mutation and ypk1 ypk2double mutation; potential Cdc28p substrate 0.559370.84696 S000000340MEC1YBR136WverifiedGenome integrity checkpoint protein and PI kinase superfamilymember; signal transducer required for cellcycle arrest and transcriptional responsesprompted by damaged or unreplicated DNA;monitors and participates in meioticrecombination 0.545730.83654 S000005124RHO5YNL180CverifiedNon-essential small GTPase of the Rho/Rac subfamily of Ras-likeproteins, likely involved in protein kinase C(Pkc1p)-dependent signal transduction pathwaythat controls cell integrity &radic0.54420.83554&radic&radic&radic&radic&radic&radic S000002717GIC2YDR309CverifiedProtein of unknown function involved in initiation of buddingand cellular polarization, interacts withCdc42p via the Cdc42/Rac-interactive binding(CRIB) domain &radic0.540880.83359&radic&radic&radic S000002787RGA2YDR379WverifiedGTPase-activating protein for the polarity-establishmentprotein Cdc42p; implicated in control of septinorganization, pheromone response, and haploidinvasive growth &radic0.537840.83358&radic&radic&radic&radic S000005227WSC2YNL283CverifiedPartially redundant sensor-transducer of the stress-activatedPKC1-MPK1 signaling pathway involved inmaintenance of cell wall integrity and recoveryfrom heat shock; secretory pathway Wsc2p isrequired for the arrest of secretion response &radic0.534030.83219&radic S000000822GPA2YER020WverifiedNucleotide binding alpha subunit of the heterotrimeric Gprotein that interacts with the receptor Gpr1p,has signaling role in response to nutrients;green fluorescent protein (GFP)-fusion proteinlocalizes to the cell periphery 0.526050.82526&radic&radic S000003542CYR1YJL005WverifiedAdenylate cyclase, required for cAMP production andcAMP-dependent protein kinase signaling;involved in cell cycle control and glucose andnitrogen repression of sporulation &radic0.519540.82194&radic S000004230VPS34YLR240WverifiedPhosphatidylinositol 3-kinase responsible for the synthesis ofphosphatidylinositol 3-phosphate; formsmembrane-associated signal transduction complexwith Vps15p to regulate protein sorting;activated by the GTP-bound form of Gpa1p &radic0.513590.8204&radic&radic S000005660BAG7YOR134WverifiedRho GTPase activating protein (RhoGAP), stimulates theintrinsic GTPase activity of Rho1p, which playsa role in actin cytoskeleton organization andcontrol of cell wall synthesis; structurallyand functionally related to Sac7p &radic0.5120.82028&radic&radic&radic&radic S000001695SAC1YKL212WverifiedLipid phosphoinositide phosphatase of the ER and Golgi,involved in protein trafficking and secretion &radic0.500210.81365&radic&radic&radic&radic&radic S000004363ROM2YLR371WverifiedGDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutationsare synthetically lethal with mutations inrom1, which also encodes a GEP &radic0.498480.81314&radic&radic&radic&radic&radic&radic S000005697LCB4YOR171CverifiedSphingoid long-chain base kinase, responsible for synthesis oflong-chain base phosphates, which function assignaling molecules, regulates synthesis ofceramide from exogenous long-chain bases,localizes to the Golgi and late endosomes &radic0.495220.81173&radic&radic&radic&radic S000002506BMH2YDR099Wverified14-3-3 protein, minor isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others &radic0.495090.81172&radic&radic&radic&radic&radic S000001421BNR1YIL159WverifiedFormin, nucleates the formation of linear actin filaments,involved in cell processes such as budding andmitotic spindle orientation which require theformation of polarized actin cables,functionally redundant with BNI1 0.487210.8064&radic S000000404BEM1YBR200WverifiedProtein containing SH3-domains, involved in establishing cellpolarity and morphogenesis; functions as ascaffold protein for complexes that includeCdc24p, Ste5p, Ste20p, and Rsr1p 0.480140.80108&radic&radic&radic S000000916BOI2YER114CverifiedProtein implicated in polar growth, functionally redundant withBoi1p; interacts with bud-emergence proteinBem1p; contains an SH3 (src homology 3) domainand a PH (pleckstrin homology) domain &radic0.474180.79592&radic&radic S000002164PTC1YDL006WverifiedType 2C protein phosphatase (PP2C); inactivates the osmosensingMAPK cascade by dephosphorylating Hog1p;mutation delays mitochondrial inheritance;deletion reveals defects in precursor tRNAsplicing, sporulation and cell separation &radic0.464360.7918 S000001103GIC1YHR061CverifiedProtein of unknown function involved in initiation of buddingand cellular polarization, interacts withCdc42p via the Cdc42/Rac-interactive binding(CRIB) domain &radic0.463570.7918&radic&radic&radic&radic&radic&radic S000005211PIK1YNL267WverifiedPhosphatidylinositol 4-kinase; catalyzes first step in thebiosynthesis ofphosphatidylinositol-4,5-biphosphate; maycontrol cytokineses through the actincytoskeleton &radic0.460120.78994&radic S000000181BOI1YBL085WverifiedProtein implicated in polar growth, functionally redundant withBoi2p; interacts with bud-emergence proteinBem1p; contains an SH3 (src homology 3) domainand a PH (pleckstrin homology) domain &radic0.45190.78472&radic&radic&radic&radic S000005734PTP2YOR208WverifiedPhosphotyrosine-specific protein phosphatase involved in theinactivation of mitogen-activated proteinkinase (MAPK) during osmolarity sensing;dephosporylates Hog1p MAPK and regulates itslocalization; localized to the nucleus &radic0.441870.77835&radic&radic S000004444SST2YLR452CverifiedGTPase-activating protein for Gpa1p, regulates desensitizationto alpha factor pheromone; also required toprevent receptor-independent signaling of themating pathway; member of the RGS (regulator ofG-protein signaling) family 0.439480.77647&radic S000001072SLT2YHR030CverifiedSerine/threonine MAP kinase involved in regulating themaintenance of cell wall integrity andprogression through the cell cycle; regulatedby the PKC1-mediated signaling pathway 0.436550.77365&radic&radic&radic&radic&radic S000000184TEL1YBL088CverifiedProtein kinase primarily involved in telomere lengthregulation; contributes to cell cyclecheckpoint control in response to DNA damage;functionally redundant with Mec1p; homolog ofhuman ataxia telangiectasia (ATM) gene 0.430120.77019 S000005473SKM1YOL113WverifiedMember of the PAK family of serine/threonine protein kinaseswith similarity to Ste20p and Cla4p; proposedto be a downstream effector of Cdc42p duringpolarized growth 0.401950.74648 S000003827TOR1YJR066WverifiedPIK-related protein kinase and rapamycin target; subunit ofTORC1, a complex that controls growth inresponse to nutrients by regulatingtranslation, transcription, ribosomebiogenesis, nutrient transport and autophagy;involved in meiosis &radic0.40020.7456&radic&radic S000001798PXL1YKR090WverifiedLIM domain-containing protein that localizes to sites ofpolarized growth, required for selection and/ormaintenance of polarized growth sites, maymodulate signaling by the GTPases Cdc42p andRho1p; has similarity to metazoan paxillin 0.392070.73901&radic&radic&radic S000004103HOG1YLR113WverifiedMitogen-activated protein kinase involved in osmoregulation viathree independent osmosensors; mediates therecruitment and activation of RNA Pol II atHot1p-dependent promoters; localizationregulated by Ptp2p and Ptp3p 0.387630.73562&radic&radic&radic S000004845FUS2YMR232WverifiedCytoplasmic protein localized to the shmoo tip; required forthe alignment of parental nuclei before nuclearfusion during mating 0.384630.73295&radic&radic&radic&radic S000002915GIN4YDR507CverifiedProtein kinase involved in bud growth and assembly of theseptin ring, proposed to have kinase-dependentand kinase-independent activities; undergoesautophosphorylation; similar to Kcc4p and Hsl1p 0.373460.72221&radic&radic S000003664PBS2YJL128CverifiedMAP kinase kinase that plays a pivotal role in the osmosensingsignal-transduction pathway, activated undersevere osmotic stress &radic0.37150.71974&radic S000001020WSC4YHL028WverifiedER membrane protein involved in the translocation of solublesecretory proteins and insertion of membraneproteins into the ER membrane; may also have arole in the stress response but has onlypartial functional overlap with WSC1-3 0.352170.69547&radic&radic&radic S000002885SNF1YDR477WverifiedAMP-activated serine/threonine protein kinase found in acomplex containing Snf4p and members of theSip1p/Sip2p/Gal83p family; required fortranscription of glucose-repressed genes,thermotolerance, sporulation, and peroxisomebiogenesis 0.35090.69321&radic S000003631BCK1YJL095WverifiedMitogen-activated protein (MAP) kinase kinase kinase acting inthe protein kinase C signaling pathway, whichcontrols cell integrity; upon activation byPkc1p phosphorylates downstream kinases Mkk1pand Mkk2p &radic0.340240.6815&radic S000000201PKC1YBL105CverifiedProtein serine/threonine kinase essential for cell wallremodeling during growth; localized to sites ofpolarized growth and the mother-daughter budneck; homolog of the alpha, beta, and gammaisoforms of mammalian protein kinase C (PKC) &radic0.339590.68094&radic&radic S000000891PTC2YER089CverifiedType 2C protein phosphatase; dephosphorylates Hog1p to limitmaximal osmostress induced kinase activity;dephosphorylates Ire1p to downregulate theunfolded protein response; dephosphorylatesCdc28p; role in DNA checkpoint inactivation &radic0.339140.68025&radic S000003302ROM1YGR070WverifiedGDP/GTP exchange protein (GEP) for Rho1p; mutations aresynthetically lethal with mutations in rom2,which also encodes a GEP &radic0.338230.67935&radic&radic S000000877PTP3YER075CverifiedPhosphotyrosine-specific protein phosphatase involved in theinactivation of mitogen-activated proteinkinase (MAPK) during osmolarity sensing;dephosporylates Hog1p MAPK and regulates itslocalization; localized to the cytoplasm &radic0.337830.67928&radic&radic&radic&radic&radic S000004250LCB5YLR260WverifiedMinor sphingoid long-chain base kinase, paralog of Lcb4presponsible for few percent of the totalactivity, possibly involved in synthesis oflong-chain base phosphates, which function assignaling molecules &radic0.33780.67928&radic&radic S000004998MSG5YNL053WverifiedDual-specificity protein phosphatase required for maintenanceof a low level of signaling through the cellintegrity pathway; regulates and is regulatedby Slt2p; also required for adaptive responseto pheromone 0.337350.67854&radic S000001855ACT1YFL039CverifiedActin, structural protein involved in cell polarization,endocytosis, and other cytoskeletal functions 0.331830.67207&radic&radic S000001649TPK3YKL166CverifiedSubunit of cAMP-dependent protein kinase, which contains Tpk1p,Tpk2p, Tpk3p, and regulatory subunit Bcy1p;promotes growth in response to nutrients;mediates induction of apoptosis due toactin-mediated hyperactivation of Ras signaling 0.328890.66811&radic&radic&radic S000000537STE50YCL032WverifiedProtein involved in mating response, invasive/filamentousgrowth, and osmotolerance, acts as an adaptorthat links G protein-associated Cdc42p-Ste20pcomplex to the effector Ste11p to modulatesignal transduction &radic0.328230.66744&radic&radic&radic S000001889SEC4YFL005WverifiedSecretory vesicle-associated Rab GTPase essential forexocytosis; associates with the exocystcomponent Sec15p and may regulate polarizeddelivery of transport vesicles to the exocystat the plasma membrane &radic0.328010.66729 S000001924CDC14YFR028CverifiedProtein phosphatase required for mitotic exit; located in thenucleolus until liberated by the FEAR andMitotic Exit Network in anaphase, enabling itto act on key substrates to effect a decreasein CDK/B-cyclin activity and mitotic exit 0.316820.65215 S000003677YAK1YJL141CverifiedSerine-threonine protein kinase that is part of aglucose-sensing system involved in growthcontrol in response to glucose availability;translocates from the cytoplasm to the nucleusand phosphorylates Pop2p in response to aglucose signal 0.315760.65126 S000006124TPK2YPL203WverifiedSubunit of cytoplasmic cAMP-dependent protein kinase, whichcontains redundant catalytic subunits Tpk1p,Tpk2p, and Tpk3p and regulatory subunit Bcy1p;promotes vegetative growth in response tonutrients; activates filamentous growth &radic0.315740.65126&radic&radic&radic S000000112FUS3YBL016WverifiedMitogen-activated protein kinase involved in mating pheromoneresponse; activated by phosphorylation bySte7p; provides specificity during the matingvs. filamentous growth response byphosphorylating transcriptional and cytoplasmictargets 0.313930.64942&radic&radic&radic&radic&radic S000000202SRO77YBL106CverifiedProtein with roles in exocytosis and cation homeostasis;functions in docking and fusion of post-Golgivesicles with plasma membrane; homolog of Sro7pand Drosophila lethal giant larvae tumorsuppressor; interacts with SNARE protein Sec9p 0.303860.6373 S000005757MKK1YOR231WverifiedMitogen-activated kinase kinase involved in protein kinase Csignaling pathway that controls cell integrity;upon activation by Bck1p phosphorylatesdownstream target, Slt2p; functionallyredundant with Mkk2p 0.292630.62381&radic&radic&radic S000006163IQG1YPL242CverifiedEssential protein required for determination of buddingpattern, promotes localization of axial markersBud4p and Cdc12p and functionally interactswith Sec3p, localizes to the contractile ringduring anaphase, member of the IQGAP family 0.289460.62026&radic S000003700TPK1YJL164CverifiedSubunit of cytoplasmic cAMP-dependent protein kinase, whichcontains redundant catalytic subunits Tpk1p,Tpk2p, and Tpk3p and regulatory subunit Bcy1p;promotes vegetative growth in response tonutrients; inhibits filamentous growth &radic0.288020.61914&radic&radic&radic S000000152PTC3YBL056WverifiedType 2C protein phosphatase; dephosphorylates Hog1p (see alsoPtc2p) to limit maximal kinase activity inducedby osmotic stress; dephosphorylates T169phosphorylated Cdc28p (see also Ptc2p); role inDNA checkpoint inactivation &radic0.28750.61885&radic&radic&radic&radic S000003723SWE1YJL187CverifiedProtein kinase that regulates the G2/M transition by inhibitionof Cdc28p kinase activity; localizes to thenucleus and to the daughter side of themother-bud neck; homolog of S. pombe Wee1p;potential Cdc28p substrate 0.279090.60873&radic&radic S000001847RGD2YFL047WverifiedGTPase-activating protein (RhoGAP) for Cdc42p and Rho5p &radic0.275990.60463&radic S000004284GSP1YLR293CverifiedGTP binding protein (mammalian Ranp homolog) involved in themaintenance of nuclear organization, RNAprocessing and transport; regulated by Prp20p,Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p andKap95p; yeast Gsp2p homolog 0.270470.59772&radic&radic&radic S000001861RIM15YFL033CverifiedGlucose-repressible protein kinase involved in signaltransduction during cell proliferation inresponse to nutrients, specifically theestablishment of stationary phase; originallyidentified as a regulator of IME2 0.269610.59656&radic S000001609YPK1YKL126WverifiedSerine/threonine protein kinase required for receptor-mediatedendocytosis; involved in sphingolipid-mediatedand cell integrity signaling pathways;localized to the bud neck, cytosol and plasmamembrane; homolog of mammalian kinase SGK 0.26640.5925&radic&radic&radic&radic S000005314SSK2YNR031CverifiedMAP kinase kinase kinase of the HOG1 mitogen-activatedsignaling pathway; interacts with Ssk1p,leading to autophosphorylation and activationof Ssk2p which phosphorylates Pbs2p; alsomediates actin cytoskeleton recovery fromosmotic stress &radic0.265260.59101&radic S000003272KSS1YGR040WverifiedMitogen-activated protein kinase (MAPK) involved in signaltransduction pathways that control filamentousgrowth and pheromone response 0.262770.58737&radic S000001248SCH9YHR205WverifiedProtein kinase that regulates signal transduction activity andG1 progression, controls cAPK activity,required for nitrogen activation of the FGMpathway, involved in life span regulation,homologous to mammalian Akt/PKB 0.261270.58519&radic S000003636LSB6YJL100WverifiedPhosphatidylinositol 4-kinase that binds Las17p, which is ahomolog of human Wiskott-Aldrich Syndromeprotein involved in actin patch assembly andactin polymerization &radic0.261010.58504 S000001865CAK1YFL029CverifiedCyclin-dependent kinase-activating kinase required for passagethrough the cell cycle, phosphorylates andactivates Cdc28p; nucleotide-binding pocketdiffers significantly from those of most otherprotein kinases 0.257350.58082&radic S000003324DBF2YGR092WverifiedSer/Thr kinase involved in transcription and stress response;functions as part of a network of genes in exitfrom mitosis; localization is cell cycleregulated; activated by Cdc15p during the exitfrom mitosis 0.256550.57983&radic S000001465YVH1YIR026CverifiedProtein phosphatase involved in vegetative growth at lowtemperatures, sporulation, and glycogenaccumulation; transcription induced by lowtemperature and nitrogen starvation; member ofthe dual-specificity family of proteinphosphatases 0.255730.57827&radic S000001445PAN1YIR006CverifiedPart of actin cytoskeleton-regulatory complexPan1p-Sla1p-End3p, associates with actinpatches on the cell cortex; promotesprotein-protein interactions essential forendocytosis; previously thought to be a subunitof poly(A) ribonuclease 0.252380.57455&radic S000000602RVS161YCR009CverifiedAmphiphysin-like lipid raft protein; subunit of a complex(Rvs161p-Rvs167p) that regulates polarizationof the actin cytoskeleton, endocytosis, cellpolarity, cell fusion and viability followingstarvation or osmotic stress 0.244690.56262&radic&radic&radic S000004252YPT6YLR262CverifiedGTPase, Ras-like GTP binding protein involved in the secretorypathway, required for fusion ofendosome-derived vesicles with the late Golgi,maturation of the vacuolar carboxypeptidase Y;has similarity to the human GTPase, Rab6 0.243350.56025&radic&radic S000001575BUD2YKL092CverifiedGTPase activating factor for Rsr1p/Bud1p required for bothaxial and bipolar budding patterns; mutantsexhibit random budding in all cell types &radic0.237740.55284&radic&radic&radic S000001856YPT1YFL038CverifiedRas-like small GTPase, involved in the ER-to-Golgi step of thesecretory pathway; complex formation with theRab escort protein Mrs6p is required forprenylation of Ypt1p by proteingeranylgeranyltransferase type II (Bet2p-Bet4p) 0.232050.54659&radic&radic S000000634BUD5YCR038CverifiedGTP/GDP exchange factor for Rsr1p (Bud1p) required for bothaxial and bipolar budding patterns; mutantsexhibit random budding in all cell types &radic0.231190.54527 S000004086KIN2YLR096WverifiedSerine/threonine protein kinase involved in regulation ofexocytosis; localizes to the cytoplasmic faceof the plasma membrane; closely related toKin1p 0.230210.54386&radic&radic&radic S000005952PHO85YPL031CverifiedCyclin-dependent kinase, with ten cyclin partners; involved inenvironmental stress response; inphosphate-rich conditions, Pho85p-Pho80pcomplex phosphorylates Pho4p which in turnrepresses PHO5 0.227990.54081&radic&radic&radic&radic S000000072CDC15YAR019CverifiedProtein kinase of the Mitotic Exit Network that is localized tothe spindle pole bodies at late anaphase;promotes mitotic exit by directly switching onthe kinase activity of Dbf2p 0.223920.53443 S000000480PPS1YBR276CverifiedProtein phosphatase with specificity for serine, threonine, andtyrosine residues; has a role in the DNAsynthesis phase of the cell cycle 0.223720.53409 S000003737ECM25YJL201WverifiedNon-essential protein of unknown function; promoter contains aconsensus binding sequence for factor Abf1p 0.222940.53288&radic S000005028END3YNL084CverifiedEH domain-containing protein involved in endocytosis, actincytoskeletal organization and cell wallmorphogenesis; forms a complex with Sla1p andPan1p 0.220550.52974 S000000143EDE1YBL047CverifiedKey endocytic protein involved in a network of interactionswith other endocytic proteins, binds membranesin a ubiquitin-dependent manner, may also bindubiquitinated membrane-associated proteins 0.219510.52804&radic S000000669SSK22YCR073CverifiedMAP kinase kinase kinase of the HOG1 mitogen-activatedsignaling pathway; functionally redundant with,and homologous to, Ssk2p; interacts with and isactivated by Ssk1p; phosphorylates Pbs2p &radic0.218540.52692 S000005827RAX1YOR301WverifiedProtein involved in bud site selection during bipolar budding;localization requires Rax2p; has similarity tomembers of the insulin-related peptidesuperfamily 0.218450.52651 S000005127NPR1YNL183CverifiedProtein kinase that stabilizes several plasma membrane aminoacid transporters by antagonizing theirubiquitin-mediated degradation 0.214750.52052&radic&radic&radic&radic S000005269FIG4YNL325CverifiedProtein required for efficient mating, member of a family ofeukaryotic proteins that contain a domainhomologous to Sac1p 0.21430.52001&radic&radic S000001121IRE1YHR079CverifiedSerine-threonine kinase and endoribonuclease; transmembraneprotein that initiates the unfolded proteinresponse signal by regulating synthesis ofHac1p through HAC1 mRNA splicing &radic0.213770.51906&radic&radic&radic S000001144KIC1YHR102WverifiedProtein kinase of the PAK/Ste20 kinase family, required forcell integrity possibly through regulating1,6-beta-glucan levels in the wall; physicallyinteracts with Cdc31p (centrin), which is acomponent of the spindle pole body 0.213070.51825&radic S000002569NBP2YDR162CverifiedProtein involved in the HOG (high osmolarity glycerol) pathway,negatively regulates Hog1p by recruitment ofphosphatase Ptc1p the Pbs2p-Hog1p complex,found in the nucleus and cytoplasm, contains anSH3 domain that binds Pbs2p 0.211980.51616&radic&radic S000002529KIN1YDR122WverifiedSerine/threonine protein kinase involved in regulation ofexocytosis; localizes to the cytoplasmic faceof the plasma membrane; closely related toKin2p 0.208340.50987&radic&radic&radic&radic S000002248RAM1YDL090CverifiedBeta subunit of the CAAX farnesyltransferase (FTase) thatprenylates the a-factor mating pheromone andRas proteins; required for the membranelocalization of Ras proteins and a-factor;homolog of the mammalian FTase beta subunit 0.20470.50356&radic&radic&radic S000002266KIN28YDL108WverifiedSerine/threonine protein kinase, subunit of the transcriptionfactor TFIIH; involved in transcriptioninitiation at RNA polymerase II promoters 0.20410.50315 S000005105CBK1YNL161WverifiedSerine/threonine protein kinase that regulates cellmorphogenesis pathways; involved in cell wallbiosynthesis, apical growth, proper matingprojection morphology, bipolar bud siteselection in diploid cells, and cell separation 0.203270.50159&radic&radic&radic S000005468INO4YOL108CverifiedTranscription factor required for derepression ofinositol-choline-regulated genes involved inphospholipid synthesis; forms a complex, withIno2p, that binds theinositol-choline-responsive element through abasic helix-loop-helix domain 0.203030.50105&radic S000004603CDC5YMR001CverifiedPolo-like kinase with similarity to Xenopus Plx1 and S. pombePlo1p; found at bud neck, nucleus and SPBs; hasmultiple functions in mitosis and cytokinesisthrough phosphorylation of substrates; may be aCdc28p substrate 0.200340.49743&radic S000002389PTP1YDL230WverifiedPhosphotyrosine-specific protein phosphatase thatdephosphorylates a broad range of substrates invivo, including Fpr3p; localized to thecytoplasm and the mitochondria 0.200350.49743&radic S000001141TRA1YHR099WverifiedSubunit of SAGA and NuA4 histone acetyltransferase complexes;interacts with acidic activators (e.g., Gal4p)which leads to transcription activation;similar to human TRRAP, which is a cofactor forc-Myc mediated oncogenic transformation 0.199650.49541 S000001225YHR182WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm 0.197770.4924&radic S000006365SGV1YPR161CverifiedCyclin (Bur2p)-dependent protein kinase that functions intranscriptional regulation; phosphorylates thecarboxy-terminal domain of Rpo21p, which is thelargest subunit of RNA polymerase II; regulatedby Cak1p 0.197710.49228 S000000301VPS15YBR097WverifiedMyristoylated serine/threonine protein kinase involved invacuolar protein sorting; functions as amembrane-associated complex with Vps34p; activeform recruits Vps34p to the Golgi membrane;interacts with the GDP-bound form of Gpa1p &radic0.195920.48916 S000001531ELM1YKL048CverifiedSerine/threonine protein kinase that regulates cellularmorphogenesis, septin behavior, andcytokinesis; required for the regulation ofother kinases; forms part of the bud neck ring 0.194710.48657&radic&radic&radic S000000199RTG3YBL103CverifiedBasic helix-loop-helix-leucine zipper (bHLH/Zip) transcriptionfactor that forms a complex with anotherbHLH/Zip protein, Rtg1p, to activate theretrograde (RTG) and TOR pathways &radic0.194450.48644&radic S000005853MYO2YOR326WverifiedOne of two type V myosin motors (along with MYO4) involved inactin-based transport of cargos; required forthe polarized delivery of secretory vesicles,the vacuole, late Golgi elements, peroxisomes,and the mitotic spindle 0.190290.48063&radic&radic&radic S000006125HRR25YPL204WverifiedProtein kinase involved in regulating diverse events includingvesicular trafficking, gene expression, DNArepair, and chromosome segregation; binds theCTD of RNA pol II; homolog of mammalian caseinkinase 1delta (CK1delta) 0.188380.47736&radic&radic S000006074RAD53YPL153CverifiedProtein kinase, required for cell-cycle arrest in response toDNA damage; activated by transautophosphorylation when interacting withhyperphosphorylated Rad9p; also interacts withARS1 and plays a role in initiation of DNAreplication 0.188320.47709&radic&radic S000002408NTH1YDR001CverifiedNeutral trehalase, degrades trehalose; required forthermotolerance and may mediate resistance toother cellular stresses; may be phosphorylatedby Cdc28p 0.188060.47663&radic S000004747RIM11YMR139WverifiedProtein kinase required for signal transduction during entryinto meiosis; promotes the formation of theIme1p-Ume6p complex by phosphorylating Ime1pand Ume6p; shares similarity with mammalianglycogen synthase kinase 3-beta 0.187210.47511&radic S000000329PTC4YBR125CverifiedCytoplasmic type 2C protein phosphatase; identified as ahigh-copy number suppressor of the syntheticlethality of a cnb1 mpk1 double deletion;overexpression decreases high-osmolarityinduced Hog1p phosphorylation and kinaseactivity 0.183940.46922&radic S000001622CTK1YKL139WverifiedCatalytic (alpha) subunit of C-terminal domain kinase I(CTDK-I), which phosphorylates the C-terminalrepeated domain of the RNA polymerase II largesubunit (Rpo21p) to affect both transcriptionand pre-mRNA 3' end processing 0.183230.46782&radic&radic&radic S000000364CDC28YBR160WverifiedCatalytic subunit of the main cell cycle cyclin-dependentkinase (CDK); alternately associates with G1cyclins (CLNs) and G2/M cyclins (CLBs) whichdirect the CDK to specific substrates 0.180570.46419&radic S000005616PTC5YOR090CverifiedMitochondrially localized type 2C protein phosphatase involvedin regulation of pyruvate dehydrogenaseactivity; contains Mg2+/Mn2+-dependent caseinphosphatase activity in vitro 0.18050.46399&radic&radic S000004710YPK2YMR104CverifiedProtein kinase with similarityto serine/threonine proteinkinase Ypk1p; functionally redundant with YPK1at the genetic level; participates in asignaling pathway required for optimal cellwall integrity; homolog of mammalian kinase SGK 0.179970.46278&radic S000001295BCY1YIL033CverifiedRegulatory subunit of the cyclic AMP-dependent protein kinase(PKA), a component of a signaling pathway thatcontrols a variety of cellular processes,including metabolism, cell cycle, stressresponse, stationary phase, and sporulation 0.175330.45492&radic S000005738STE4YOR212WverifiedG protein beta subunit, forms a dimer with Ste18p to activatethe mating signaling pathway, forms aheterotrimer with Gpa1p and Ste18p to dampensignaling; may recruit Rho1p to the polarizedgrowth site during mating; contains WD40repeats 0.172330.44911&radic&radic&radic&radic S000004952SIS1YNL007CverifiedType II HSP40 co-chaperone that interacts with the HSP70protein Ssa1p; not functionally redundant withYdj1p due to due to substrate specificity;shares similarity with bacterial DnaJ proteins 0.171660.44782&radic S000005020MKS1YNL076WverifiedPleiotropic regulatory factor involved in Ras-CAMP and lysinebiosynthetic pathways and nitrogen regulation;involved in retrograde (RTG)mitochondria-to-nucleus signaling &radic0.169480.44425&radic&radic S000000833YPT31YER031CverifiedGTPase of the Ypt/Rab family, very similar to Ypt32p; involvedin the exocytic pathway; mediates intra-Golgitraffic or the budding of post-Golgi vesiclesfrom the trans-Golgi 0.169080.44365&radic S000005886VTS1YOR359WverifiedPost-transcriptional gene regulator, RNA-binding proteincontaining a SAM domain; shows geneticinteractions with Vti1p, which is a v-SNAREinvolved in cis-Golgi membrane traffic 0.167820.4412&radic&radic S000001930PHO4YFR034CverifiedBasic helix-loop-helix (bHLH) transcription factor; bindscooperatively with Pho2p to the PHO5 promoter;function is regulated by phosphorylation atmultiple sites and by phosphate availability 0.167430.44066&radic&radic&radic S000002530INO2YDR123CverifiedComponent of the heteromeric Ino2p/Ino4p basic helix-loop-helixtranscription activator that bindsinositol/choline-responsive elements (ICREs),required for derepression of phospholipidbiosynthetic genes in response to inositoldepletion 0.166010.43812&radic&radic&radic S000006061MKK2YPL140CverifiedMitogen-activated kinase kinase involved in protein kinase Csignaling pathway that controls cell integrity;upon activation by Bck1p phosphorylatesdownstream target, Slt2p; functionallyredundant with Mkk1p 0.165710.43766&radic&radic&radic S000000951PEA2YER149CverifiedCoiled-coil polarisome protein required for polarizedmorphogenesis, cell fusion, and low affinityCa2+ influx; forms polarisome complex withBni1p, Bud6p, and Spa2p; localizes to sites ofpolarized growth &radic0.163530.43373&radic&radic S000005037YPT53YNL093WverifiedGTPase, similar to Ypt51p and Ypt52p and to mammalian rab5;required for vacuolar protein sorting andendocytosis 0.162520.43167 S000006236SRO7YPR032WverifiedPutative effector of Rab GTPase Sec4p, forms a complex withSec4p and t-SNARE Sec9p; involved in exocytosisand docking and fusion of post-Golgi vesicleswith plasma membrane; homolog of Sro77p andDrosophila lgl tumor suppressor &radic0.161110.42958&radic&radic S000003621EXO70YJL085WverifiedEssential 70kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which has the essential function ofmediating polarized targeting of secretoryvesicles to active sites of exocytosis 0.16070.42851&radic S000005330YNR047WUncharacterizedPutative protein kinase that, when overexpressed, interferes with pheromone-induced growth arrest; localizes to the cytoplasm; potential Cdc28p substrate 0.159540.42602&radic S000002175CDC7YDL017WverifiedDDK (Dbf4-dependent kinase) catalytic subunit required forfiring origins and replication fork progressionin mitosis through phosphorylation of Mcm2-7pcomplexes and Cdc45p; kinase activitycorrelates with cyclical DBF4 expression 0.154640.41645&radic S000005963SSN3YPL042CverifiedCyclin-dependent protein kinase, component of RNA polymerase IIholoenzyme; involved in phosphorylation of theRNA polymerase II C-terminal domain; involvedin glucose repression 0.154710.41645&radic&radic S000004238RCK2YLR248WverifiedProtein kinase involved in the response to oxidative andosmotic stress; identified as suppressor of S.pombe cell cycle checkpoint mutations 0.151850.41144&radic&radic S000002318STE7YDL159WverifiedSignal transducing MAP kinase kinase involved in pheromoneresponse, where it phosphorylates Fus3p, and inthe pseudohyphal/invasive growth pathway,through phosphorylation of Kss1p;phosphorylated by Ste11p, degraded by ubiquitinpathway 0.15170.41129&radic S000003126RCK1YGL158WverifiedProtein kinase involved in the response to oxidative stress;identified as suppressor of S. pombe cell cyclecheckpoint mutations 0.151370.4108 S000004529TEM1YML064CverifiedGTP-binding protein of the ras superfamily involved intermination of M-phase; controls actomyosin andseptin dynamics during cytokinesis 0.148380.40569 S000002133PTC6YCR079WverifiedPhosphoprotein phosphatase type 2C; contains mitochondrialtargeting sequence; green fluorescent protein(GFP)-fusion protein localizes to themitochondrion; null mutant is sensitive torapamycin 0.143790.39649 S000005216SEC2YNL272CverifiedGuanyl-nucleotide exchange factor for the small G-proteinSec4p, located on cytoplasmic vesicles;essential for post-Golgi vesicle transport 0.143130.39518&radic&radic&radic S000003619TAX4YJL083WverifiedProtein involved in regulation of phosphatidylinositol4,5-bisphosphate concentrations; Irs4p andTax4p bind and activate the phosphatase Inp51p &radic0.142650.39415 S000006259SEC8YPR055WverifiedEssential 121kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which has the essential function ofmediating polarized targeting of secretoryvesicles to active sites of exocytosis 0.141780.39231&radic&radic S000004862GAD1YMR250WverifiedGlutamate decarboxylase, converts glutamate intogamma-aminobutyric acid (GABA) during glutamatecatabolism; involved in response to oxidativestress 0.139690.38827&radic&radic S000002898PKH1YDR490CverifiedSerine/threonine protein kinase involved insphingolipid-mediated signaling pathway thatcontrols endocytosis; activates Ypk1p andYkr2p, components of signaling cascade requiredfor maintenance of cell wall integrity;redundant with Pkh2p &radic0.138750.38639 S000002378DTD1YDL219WverifiedD-Tyr-tRNA(Tyr) deacylase, functions in protein translation,may affect nonsense suppression via alterationof the protein synthesis machinery; ubiquitousamong eukaryotes 0.137750.38513&radic S000006190KAR9YPL269WverifiedKaryogamy protein required for correct positioning of themitotic spindle and for orienting cytoplasmicmicrotubules, localizes at the shmoo tip inmating cells and at the tip of the growing budin small-budded cells through anaphase 0.137330.38434&radic&radic&radic&radic S000005251MCK1YNL307CverifiedProtein serine/threonine/tyrosine (dual-specificity) kinaseinvolved in control of chromosome segregationand in regulating entry into meiosis; relatedto mammalian glycogen synthase kinases of theGSK-3 family 0.137320.38428&radic&radic&radic&radic&radic S000000684ABP1YCR088WverifiedActin-binding protein of the cortical actin cytoskeleton,important for activation of the Arp2/3 complexthat plays a key role actin in cytoskeletonorganization 0.136550.38281 S000000015PSK1YAL017WverifiedOne of two (see also PSK2) PAS domain containing S/T proteinkinases; coordinately regulates proteinsynthesis and carbohydrate metabolism andstorage in response to a unknown metabolitethat reflects nutritional status 0.135850.38159&radic&radic S000001584HSL1YKL101WverifiedNim1p-related protein kinase that regulates the morphogenesisand septin checkpoints; associates with theassembled septin filament; required along withHsl7p for bud neck recruitment,phosphorylation, and degradation of Swe1p 0.135380.38069&radic&radic S000004305SPH1YLR313CverifiedProtein involved in shmoo formation and bipolar bud siteselection; homologous to Spa2p, localizes tosites of polarized growth in a cell cycledependent- and Spa2p-dependent manner,interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p &radic0.135160.38004&radic&radic&radic&radic&radic S000005460PKH2YOL100WverifiedSerine/threonine protein kinase involved insphingolipid-mediated signaling pathway thatcontrols endocytosis; activates Ypk1p andYkr2p, components of signaling cascade requiredfor maintenance of cell wall integrity;redundant with Pkh1p &radic0.135010.37984&radic S000000601SAT4YCR008WverifiedSer/Thr protein kinase involved in salt tolerance; funtions inregulation of Trk1p-Trk2p potassiumtransporter; partially redundant with Hal5p;has similarity to Npr1p 0.133270.37642&radic&radic&radic&radic S000000405DER1YBR201WverifiedEndoplasmic reticulum membrane protein, required forER-associated protein degradation of misfoldedor unassembled proteins; N- and C- terminiprotrude into the cytoplasm, has similarity toDfm1p 0.13320.37623&radic&radic&radic&radic S000000263AKL1YBR059CverifiedSer-Thr protein kinase, member (with Ark1p and Prk1p) of theArk kinase family; involved in endocytosis andactin cytoskeleton organization 0.132810.37551&radic S000002435REG1YDR028CverifiedRegulatory subunit of type 1 protein phosphatase Glc7p,involved in negative regulation ofglucose-repressible genes 0.132530.37473&radic S000002478PAA1YDR071CverifiedPolyamine acetyltransferase; acetylates polyamines (e.g.putrescine, spermidine, spermine) and alsoaralkylamines (e.g. tryptamine,phenylethylamine); may be involved intranscription and/or DNA replication 0.131390.37267&radic S000005887PDE2YOR360CverifiedHigh-affinity cyclic AMP phosphodiesterase, component of thecAMP-dependent protein kinase signaling system,protects the cell from extracellular cAMP,contains readthrough motif surroundingtermination codon &radic0.13030.37023&radic&radic&radic S000002976PMA1YGL008CverifiedPlasma membrane H+-ATPase, pumps protons out of the cell; majorregulator of cytoplasmic pH and plasma membranepotential; part of the P2 subgroup ofcation-transporting ATPases 0.129060.36787&radic S000000205NTH2YBR001CverifiedPutative neutral trehalase, required for thermotolerance andmay mediate resistance to other cellularstresses 0.128450.36678&radic S000001727IRS4YKR019CverifiedProtein involved in regulation of phosphatidylinositol4,5-bisphosphate concentrations; Irs4p andTax4p bind and activate the phosphatase Inp51p;mutation confers an increase in rDNA silencing &radic0.126990.36366 S000002259DUN1YDL101CverifiedCell-cycle checkpoint serine-threonine kinase required for DNAdamage-induced transcription of certain targetgenes, phosphorylation of Rad55p and Sml1p, andtransient G2/M arrest after DNA damage; alsoregulates postreplicative DNA repair 0.126610.36282 S000005615VPS21YOR089CverifiedGTPase required for transport during endocytosis and forcorrect sorting of vacuolar hydrolases;localized in endocytic intermediates; detectedin mitochondria; geranylgeranylation requiredfor membrane association; mammalian Rab5homolog 0.125860.36138&radic&radic S000003178YPT32YGL210WverifiedGTPase of the Ypt/Rab family, very similar to Ypt31p; involvedin the exocytic pathway; mediates intra-Golgitraffic or the budding of post-Golgi vesiclesfrom the trans-Golgi 0.124580.35831&radic S000001177YCK1YHR135CverifiedPalmitoylated, plasma membrane-bound casein kinase I isoform;shares redundant functions with Yck2p inmorphogenesis, proper septin assembly,endocytic trafficking; provides an essentialfunction overlapping with that of Yck2p 0.124230.35797&radic&radic S000001366SHQ1YIL104CverifiedEssential nuclear protein, required for accumulation of boxH/ACA snoRNAs and for rRNA processing;interacts with Naf1p 0.122910.35555 S000003642IME2YJL106WverifiedSerine/threonine protein kinase involved in activation ofmeiosis, associates with Ime1p and mediates itsstability, activates Ndt80p; IME2 expression ispositively regulated by Ime1p 0.122080.35332 S000005428RTG1YOL067CverifiedTranscription factor (bHLH) involved in interorganellecommunication between mitochondria,peroxisomes, and nucleus &radic0.120520.35004&radic&radic&radic S000006177CLN2YPL256CverifiedG1 cyclin involved in regulation of the cell cycle; activatesCdc28p kinase to promote the G1 to S phasetransition; late G1 specific expression dependson transcription factor complexes, MBF(Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) 0.119390.34741&radic&radic&radic&radic&radic S000001456MET28YIR017CverifiedTranscriptional activator in the Cbf1p-Met4p-Met28p complex,participates in the regulation of sulfurmetabolism 0.118740.34607&radic&radic&radic&radic S000006161HSP82YPL240CverifiedCytoplasmic chaperone (Hsp90 family) required for pheromonesignaling and negative regulation of Hsf1p;docks with the mitochondrial import receptorTom70p for preprotein delivery; interacts withco-chaperones Cns1p, Cpr6p, Cpr7p, and Sti1p 0.118460.34523&radic&radic&radic S000001644YKL161CVerifiedProtein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; associates with Rlm1p 0.118390.34507&radic&radic&radic&radic S000005215BNI1YNL271CverifiedFormin, nucleates the formation of linear actin filaments,involved in cell processes such as budding andmitotic spindle orientation which require theformation of polarized actin cables,functionally redundant with BNR1 &radic0.118170.34489&radic&radic&radic S000005472MSB4YOL112WverifiedGTPase-activating protein of the Ras superfamily that actsprimarily on Sec4p, localizes to the bud siteand bud tip, has similarity to Msb3p; msb3 msb4double mutation causes defects in secretion andactin organization 0.116430.34116&radic S000006062YPL141CUncharacterizedHypothetical protein 0.114930.33819&radic&radic&radic&radic&radic S000003148ATG1YGL180WverifiedProtein serine/threonine kinase, required for autophagy and forthe cytoplasm-to-vacuole targeting (Cvt)pathway 0.114350.337 S000002655VHS1YDR247WverifiedCytoplasmic serine/threonine protein kinase; identified as ahigh-copy suppressor of the synthetic lethalityof a sis2 sit4 double mutant, suggesting a rolein G1/S phase progression; homolog of Sks1p 0.114140.33651&radic&radic S000001673CNB1YKL190WverifiedCalcineurin B; the regulatory subunit of calcineurin, aCa++/calmodulin-regulated protein phosphatasewhich regulates Crz1p (a stress-responsetranscription factor), the other calcineurinsubunit is encoded by CNA1 and/or CMP1 0.114110.33644&radic&radic&radic&radic&radic S000005878MEK1YOR351CverifiedMeiosis-specific serine/threonine protein kinase, functions inmeiotic checkpoint, phosphorylates Red1p,interacts with Hop1p; required for meioticrecombination and normal spore viability 0.113390.33454&radic&radic S000004924GAS1YMR307WverifiedBeta-1.3-glucanosyltransferase, required for cell wallassembly; localizes to the cell surface via aglycosylphosphatidylinositol (GPI) anchor 0.11330.33445&radic&radic S000002796RVS167YDR388WverifiedActin-associated protein, subunit of a complex(Rvs161p-Rvs167p) involved in regulation ofactin cytoskeleton, endocytosis, and viabilityfollowing starvation or osmotic stress; homologof mammalian amphiphysin 0.113240.33422&radic&radic&radic&radic S000002424KCS1YDR017CverifiedInositol hexaphosphate kinase, phosphorylates inositolhexakisphosphate (InsP6) to diphosphoinositolpolyphosphates, required for proper vacuolemorphology and involved in salt stressresponse, contains two leucine heptad repeats 0.113260.33422&radic S000002428FAL1YDR021WverifiedNucleolar protein required for maturation of 18S rRNA, memberof the eIF4A subfamily of DEAD-boxATP-dependent RNA helicases 0.113120.33409 S000005098YCK2YNL154CverifiedPalmitoylated, plasma membrane-bound casein kinase I isoform;shares redundant functions with Yck1p inmorphogenesis, proper septin assembly,endocytic trafficking; provides an essentialfunction overlapping with that of Yck1p 0.112310.33232&radic&radic&radic&radic&radic&radic S000001124KSP1YHR082CverifiedNonessential putative serine/threonine protein kinase ofunknown cellular role; overproduction causesallele-specific suppression of the prp20-10mutation 0.11190.33132&radic&radic&radic S000001535ASK1YKL052CverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; phosphorylated duringthe cell cycle by cyclin-dependent kinases 0.111660.33064&radic&radic&radic S000000103SLA1YBL007CverifiedCytoskeletal protein binding protein required for assembly ofthe cortical actin cytoskeleton; contains 3 SH3domains; interacts with proteins regulatingactin dynamics and with proteins required forendocytosis 0.111660.33064&radic&radic&radic S000000478CHK1YBR274WverifiedDNA damage checkpoint effector kinase, mediates mitotic cellcycle arrest via phosphorylation of Pds1p;phosphorylated by checkpoint signal transducerkinase Mec1p; homolog of S. pombe and mammalianChk1 checkpoint kinase 0.11150.33036&radic S000003571KAR2YJL034WverifiedATPase involved in protein import into the ER, also acts as achaperone to mediate protein folding in the ERand may play a role in ER export of solubleproteins; regulates the unfolded proteinresponse via interaction with Ire1p 0.111440.33022 S000000306EXO84YBR102CverifiedEssential protein with dual roles in spliceosome assembly andexocytosis; the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p) mediates polarized targeting ofsecretory vesicles to active sites ofexocytosis 0.110650.32845&radic S000003820PTK2YJR059WverifiedPutative serine/threonine protein kinase involved in regulationof ion transport across plasma membrane;enhances spermine uptake 0.109970.32662&radic S000005587CKA2YOR061WverifiedAlpha' catalytic subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKB1 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.109930.32653&radic&radic&radic&radic&radic S000003215RAI1YGL246CverifiedNuclear protein that binds to and stabilizes theexoribonuclease Rat1p, required for pre-rRNAprocessing 0.109390.3254&radic&radic S000001375SDP1YIL113WverifiedStress-inducible dual-specificity MAP kinase phosphatase,negatively regulates Slt2p MAP kinase by directdephosphorylation, diffuse localization undernormal conditions shifts to punctatelocalization after heat shock &radic0.108370.3232 S000003871YMR1YJR110WverifiedPhosphatidylinositol 3-phosphate [PI(3)P] phosphatase,regulates the localization and levels ofPI(3)P; involved in cytoplasm to vacuole (CVT)transport; has similarity to the conservedmyotubularin dual specificity phosphatasefamily &radic0.107440.32064&radic S000001297CKA1YIL035CverifiedAlpha catalytic subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA2, CKB1 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.107320.32043&radic&radic S000004311BUD6YLR319CverifiedActin- and formin-interacting protein, involved in actin cablenucleation and polarized cell growth; isolatedas bipolar budding mutant; potential Cdc28psubstrate &radic0.106940.31975&radic&radic&radic&radic S000001562SMY1YKL079WverifiedProtein that interacts with Myo2p, proposed to be involved inexocytosis; N-terminal domain is related to themotor domain of kinesins 0.106680.31927&radic&radic&radic&radic S000000171SSA3YBL075CverifiedATPase involved in protein folding and the response to stress;plays a role in SRP-dependent cotranslationalprotein-membrane targeting and translocation;member of the heat shock protein 70 (HSP70)family; localized to the cytoplasm 0.106120.31814&radic&radic&radic S000001756NAP1YKR048CverifiedProtein that interacts with mitotic cyclin Clb2p; required forthe regulation of microtubule dynamics duringmitosis; controls bud morphogenesis; involvedin the transport of H2A and H2B histones to thenucleus 0.103510.31137&radic&radic&radic S000000810SEC3YER008CverifiedNon-essential subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, Exo84p)which mediates targeting of post-Golgi vesiclesto sites of active exocytosis; Sec3pspecifically is a spatial landmark forsecretion 0.103350.31092&radic&radic&radic S000005648PFY1YOR122CverifiedProfilin, actin- and phosphatidylinositol4,5-bisphosphate-binding protein, plays a rolein cytoskeleton organization, required fornormal timing of actin polymerization inresponse to thermal stress; localizes to plasmamembrane and cytosol 0.103240.31055&radic&radic&radic S000003465PHO81YGR233CverifiedCyclin-dependent kinase (CDK) inhibitor, regulatesPho80p-Pho85p and Pcl7p-Pho85p cyclin-CDKcomplexes in response to phosphate levels;required for derepression of PHO5;transcriptionally regulated by Pho4p and Pho2p 0.101120.30564&radic&radic&radic S000005376CMK2YOL016CverifiedCalmodulin-dependent protein kinase; may play a role in stressresponse, many CA++/calmodulan dependentphosphorylation substrates demonstrated invitro, amino acid sequence similar to Cmk1p andmammalian Cam Kinase II 0.101140.30564&radic S000005711GSP2YOR185CverifiedGTP binding protein (mammalian Ranp homolog) involved in themaintenance of nuclear organization, RNAprocessing and transport; interacts withKap121p, Kap123p and Pdr6p (karyophilin betas);Gsp1p homolog that is not required forviability 0.100950.30519&radic&radic&radic S000006368MMS1YPR164WverifiedProtein likely involved in protection againstreplication-dependent DNA damage; mutants aresensitive to methyl methanesulfonate (MMS);implicated in regulation of Ty1 transposition 0.10010.30297&radic&radic&radic S000005426INP54YOL065CverifiedPhosphatidylinositol 4,5-bisphosphate 5-phosphatase with a rolein secretion, localizes to the endoplasmicreticulum via the C-terminal tail; lacks theSac1 domain and proline-rich region found inthe other 3 INP proteins &radic0.100070.3029&radic&radic&radic&radic S000000368ARL1YBR164CverifiedSoluble GTPase with a role in regulation of membrane traffic;regulates potassium influx; G protein of theRas superfamily, similar to ADP-ribosylationfactor 0.099790.30192 S000003821CBF1YJR060WverifiedHelix-loop-helix protein that binds the motif CACRTG, which ispresent at several sites including MET genepromoters and centromere DNA element I (CDEI);required for nucleosome positioning at thismotif; targets Isw1p to DNA 0.099120.30029 S000000019CCR4YAL021CverifiedComponent of the CCR4-NOT transcriptional complex, which isinvolved in regulation of gene expression;component of the major cytoplasmic deadenylase,which is involved in mRNA poly(A) tailshortening 0.098580.29881&radic&radic S000004951LST8YNL006WverifiedProtein required for the transport of amino acid permease Gap1pfrom the Golgi to the cell surface; componentof the TOR signaling pathway; associates withboth Tor1p and Tor2p; contains a WD-repeat &radic0.09840.29842 S000005558HMS1YOR032CverifiedBasic helix-loop-helix (bHLH) protein with similarity tomyc-family transcription factors;overexpression confers hyperfilamentous growthand suppresses the pseudohyphal filamentationdefect of a diploid mep1 mep2 homozygous nullmutant 0.09710.29549&radic S000005972ARL3YPL051WverifiedGTPase of the Ras superfamily required to recruit Arl1p to theGolgi; similar to ADP-ribosylation factor 0.096940.2952&radic&radic&radic&radic&radic S000002183YDL025CUncharacterizedPutative protein kinase, potentially phosphorylated by Cdc28p; YDL025C is not an essential gene 0.096670.29451 S000004466YAP1YML007WverifiedBasic leucine zipper (bZIP) transcription factor required foroxidative stress tolerance; mediatespleiotropic drug and metal resistance;localized to the nucleus in response to thepresence of oxidants 0.096430.29384&radic&radic&radic S000004324MID2YLR332WverifiedO-glycosylated plasma membrane protein that acts as a sensorfor cell wall integrity signaling and activatesthe pathway; interacts with Rom2p, a guaninenucleotide exchange factor for Rho1p, and withcell integrity pathway protein Zeo1p 0.095680.29179 S000000821ISC1YER019WverifiedInositol phosphosphingolipid phospholipase C, hydrolyzesinositolphosphosphingolipids, activated byphosphatidylserine, cardiolipin, andphosphatidylglycerol, mediates Na+ and Li+halotolerance, contains a P loop-like domain 0.095190.29037&radic&radic&radic S000005173URE2YNL229CverifiedNitrogen catabolite repression regulator that acts byinhibition of GLN3 transcription in goodnitrogen source; altered form of Ure2p creates[URE3] prion 0.095120.29014&radic&radic S000000232YBR028CUncharacterizedHypothetical protein 0.094160.28724&radic S000006189PLC1YPL268WverifiedPhosphoinositide-specific phospholipase C, hydrolyzesphosphatidylinositol 4,5-biphosphate (PIP2) togenerate inositol 1,4,5-triphosphate (IP3) and1,2-diacylglycerol (DAG); involved inkinetochore function and pseudohyphaldifferentiation 0.093720.28618 S000001402AXL2YIL140WverifiedIntegral plasma membrane protein required for axial budding inhaploid cells, localizes to the incipient budsite and bud neck; glycosylated by Pmt4p;potential Cdc28p substrate 0.093770.28618&radic S000005111SKO1YNL167CverifiedBasic leucine zipper (bZIP) transcription factor of theATF/CREB family, forms a complex with Tup1p andSsn6p to both activate and represstranscription; cytosolic and nuclear proteininvolved in osmotic and oxidative stressresponses 0.093310.28501&radic&radic&radic S000005714MSB1YOR188WverifiedProtein involved in positive regulation of both 1,3-beta-glucansynthesis and the Pkc1p-MAPK pathway, potentialCdc28p substrate; multicopy suppressor oftemperature-sensitive mutations in CDC24 andCDC42, and of mutations in BEM4 0.093150.28464&radic&radic S000001612MYO3YKL129CverifiedOne of two type I myosins; localizes to actin cortical patches;deletion of MYO3 has little effect on growth,but myo3 myo5 double deletion causes severedefects in growth and actin cytoskeletonorganization 0.092740.28348&radic&radic&radic&radic S000002573SEC5YDR166CverifiedEssential 107kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which has the essential function ofmediating polarized targeting of secretoryvesicles to active sites of exocytosis 0.092370.28265&radic&radic&radic&radic S000002351ARF1YDL192WverifiedADP-ribosylation factor, GTPase of the Ras superfamily involvedin regulation of coated formation vesicles inintracellular trafficking within the Golgi;functionally interchangeable with Arf2p 0.092040.28174&radic S000003165MDS3YGL197WverifiedProtein with an N-terminal kelch-like domain, putative negativeregulator of early meiotic gene expression;required, with Pmd1p, for growth under alkalineconditions 0.091830.28112&radic&radic S000001910CMK1YFR014CverifiedCalmodulin-dependent protein kinase; may play a role in stressresponse, many CA++/calmodulan dependentphosphorylation substrates demonstrated invitro, amino acid sequence similar to Cmk2p andmammalian Cam Kinase II 0.090330.27669&radic&radic&radic&radic S000005871TYE7YOR344CverifiedSerine-rich protein that contains a basic-helix-loop-helix(bHLH) DNA binding motif; binds E-boxes ofglycolytic genes and contributes to theiractivation; may function as a transcriptionalactivator in Ty1-mediated gene expression 0.090320.27669&radic&radic&radic&radic S000002701SSD1YDR293CverifiedProtein with a role in maintenance of cellular integrity,interacts with components of the TOR pathway;ssd1 mutant of a clinical S. cerevisiae straindisplays elevated virulence 0.09020.27646&radic&radic&radic&radic S000001149CDC12YHR107CverifiedComponent of the septin ring of the mother-bud neck that isrequired for cytokinesis; septins recruitproteins to the neck and can act as a barrierto diffusion at the membrane, and they comprisethe 10nm filaments seen with EM 0.089960.27582&radic S000004349RSC2YLR357WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; involvedin telomere maintenance 0.089070.27358&radic S000002474OCA6YDR067CuncharacterizedCytoplasmic protein required for replication of Brome mosaicvirus in S. cerevisiae, which is a model systemfor studying replication of positive-strand RNAviruses in their natural hosts 0.088840.27307&radic&radic&radic&radic S000005233PCL1YNL289WverifiedPho85 cyclin of the Pcl1,2-like subfamily, involved in entryinto the mitotic cell cycle and regulation ofmorphogenesis, localizes to sites of polarizedcell growth 0.08830.27132&radic S000003147TOS3YGL179CverifiedProtein kinase, related to and functionally redundant withElm1p and Sak1p for the phosphorylation andactivation of Snf1p; functionally orthologousto LKB1, a mammalian kinase associated withPeutz-Jeghers cancer-susceptibility syndrome 0.088280.2713 S000000071KIN3YAR018CverifiedNonessential protein kinase with unknown cellular role 0.088060.27071&radic S000005438AVO1YOL078WverifiedComponent of a membrane-bound complex containing the Tor2pkinase and other proteins, which may have arole in regulation of cell growth 0.087870.27034 S000003241SEC9YGR009Cverifiedt-SNARE protein important for fusion of secretory vesicles withthe plasma membrane; similar to but notfunctionally redundant with Spo20p; SNAP-25homolog 0.08780.27025&radic&radic&radic S000005947SKS1YPL026CverifiedPutative serine/threonine protein kinase; involved in theadaptation to low concentrations of glucoseindependent of the SNF3 regulated pathway 0.087770.27014&radic&radic S000003962UBI4YLL039CverifiedUbiquitin, becomes conjugated to proteins, marking them forselective degradation via the ubiquitin-26Sproteasome system; essential for the cellularstress response 0.087720.2699&radic&radic&radic&radic&radic S000001114ERG7YHR072WverifiedLanosterol synthase, an essential enzyme that catalyzes thecyclization of squalene 2,3-epoxide, a step inergosterol biosynthesis 0.08680.26763&radic S000005332MSO1YNR049CverifiedProbable component of the secretory vesicle docking complex,acts at a late step in secretion; shows geneticand physical interactions with Sec1p and isenriched in microsomal membrane fractions;required for sporulation 0.086620.26677&radic&radic S000000429YBR225WUncharacterizedHypothetical protein 0.086260.26618&radic&radic&radic&radic S000000687KIN82YCR091WverifiedPutative serine/threonine protein kinase, most similar tocyclic nucleotide-dependent protein kinasesubfamily and the protein kinase C subfamily 0.086230.26606&radic&radic S000005072TEP1YNL128WverifiedHomolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that haslipid phosphatase activity and is linked to thephosphatidylinositol signaling pathway; plays arole in normal sporulation &radic0.085380.26394 S000000468YPT10YBR264CverifiedGTP binding protein that contains the PEST signal sequencespecific for proteolytic enzymes; may beinvolved in vesicular transport; overexpressionleads to accumulation of Golgi-like cisternaewith budding vesicles 0.084980.26265&radic&radic&radic S000005021APJ1YNL077WverifiedPutative chaperone of the HSP40 (DNAJ) family; overexpressioninterferes with propagation of the [Psi+]prion; the authentic, non-tagged protein isdetected in highly purified mitochondria inhigh-throughput studies 0.084880.26247&radic S000000622RHB1YCR027CverifiedPutative Rheb-related GTPase involved in regulating canavanineresistance and arginine uptake; member of theRas superfamily of G-proteins 0.084810.26235&radic S000004977SIW14YNL032WverifiedTyrosine phosphatase that plays a role in actin filamentorganization and endocytosis; localized to thecytoplasm 0.084420.26119&radic S000000065RFA1YAR007CverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 0.083790.25946&radic&radic&radic S000001184CHS7YHR142WverifiedProtein of unknown function, involved in chitin biosynthesis byregulating Chs3p export from the ER 0.083740.25942&radic&radic S000001388STH1YIL126WverifiedATPase component of the ATP-dependent RSC chromatin remodelingcomplex required for kinetochore function inchromosome segregation; required for expressionof early meiotic genes; essentialhelicase-related protein homologous to Snf2p 0.083550.25885 S000001587GFA1YKL104CverifiedGlutamine-fructose-6-phosphate amidotransferase, catalyzes theformation of glucosamine-6-P and glutamate fromfructose-6-P and glutamine in the first step ofchitin biosynthesis 0.083430.2584&radic&radic S000005194RAD50YNL250WverifiedSubunit of MRX complex, with Mre11p and Xrs2p, involved inprocessing double-strand DNA breaks invegetative cells, initiation of meiotic DSBs,telomere maintenance, and nonhomologous endjoining 0.083420.2584&radic S000003420BUB1YGR188CverifiedProtein kinase that forms a complex with Mad1p and Bub3p thatis crucial in the checkpoint mechanism requiredto prevent cell cycle progression into anaphasein the presence of spindle damage, associateswith centromere DNA via Skp1p 0.08340.2584 S000005436MDM20YOL076WverifiedNon-catalytic subunit of the NatB N-terminal acetyltransferase,which catalyzes acetylation of theamino-terminal methionine residues of allproteins beginning with Met-Asp or Met-Glu andof some proteins beginning with Met-Asn orMet-Met; involved in mitochondrial inheritanceand actin assembly 0.08270.25658&radic&radic&radic&radic&radic&radic S000003899IML1YJR138WverifiedProtein of unknown function, green fluorescent protein(GFP)-fusion protein localizes to the vacuolarmembrane 0.082590.25629 S000006310ISR1YPR106WverifiedPredicted protein kinase, overexpression causes sensitivity tostaurosporine, which is a potent inhibitor ofprotein kinase C 0.082420.25574&radic&radic S000001357PRK1YIL095WverifiedProtein serine/threonine kinase; regulates the organization andfunction of the actin cytoskeleton through thephosphorylation of the Pan1p-Sla1p-End3pprotein complex 0.082310.2555&radic S000004965ARK1YNL020CverifiedSerine/threonine protein kinase involved in regulation of thecortical actin cytoskeleton; involved incontrol of endocytosis 0.081990.25435 S000002571SEC1YDR164CverifiedSm-like protein involved in docking and fusion of exocyticvesicles through binding to assembled SNAREcomplexes at the membrane; localization tosites of secretion (bud neck and bud tip) isdependent on SNARE function 0.08190.25417&radic&radic&radic&radic&radic S000004322CHS5YLR330WverifiedProtein involved in export from the Golgi to plasma membrane;involved in chitin biosynthesis through itsrole in Chs3p localization; interacts withArf1p, Bch1p, Fmp50p, Bud7p, and Chs6p 0.081220.25228&radic&radic S000000004SSA1YAL005CverifiedATPase involved in protein folding and nuclear localizationsignal (NLS)-directed nuclear transport; memberof heat shock protein 70 (HSP70) family; formsa chaperone complex with Ydj1p; localized tothe nucleus, cytoplasm, and cell wall 0.080660.25084&radic&radic&radic S000004829SKY1YMR216CverifiedSR protein kinase (SRPK) involved in regulating proteinsinvolved in mRNA metabolism and cationhomeostasis; similar to human SRPK1 0.080650.25084&radic&radic&radic S000000913SWI4YER111CverifiedDNA binding component of the SBF complex (Swi4p-Swi6p), atranscriptional activator that in concert withMBF (Mbp1-Swi6p) regulates late G1-specifictranscription of targets including cyclins andgenes required for DNA synthesis and repair 0.080220.24945&radic S000002285PCL2YDL127WverifiedG1 cyclin, associates with Pho85p cyclin-dependent kinase (Cdk)to contribute to entry into the mitotic cellcycle, essential for cell morphogenesis;localizes to sites of polarized cell growth 0.079540.24766 S000005488YGK3YOL128CverifiedProtein kinase related to mammalian glycogen synthase kinasesof the GSK-3 family; GSK-3 homologs (Mck1p,Rim11p, Mrk1p, Ygk3p) are involved in controlof Msn2p-dependent transcription of stressresponsive genes and in protein degradation 0.079470.24735 S000004460YPT7YML001WverifiedGTPase; GTP-binding protein of the rab family; required forhomotypic fusion event in vacuole inheritance,for endosome-endosome fusion, similar tomammalian Rab7 0.078580.24516&radic&radic&radic&radic S000003202SEC15YGL233WverifiedEssential 113kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which mediates polarized targeting ofvesicles to active sites of exocytosis; Sec15passociates with Sec4p and vesicles 0.078320.24452&radic&radic&radic S000001229KOG1YHR186CverifiedSubunit of TORC1, a rapamycin-sensitive complex involved ingrowth control that contains Tor1p or Tor2p,Lst8p and Tco89p; contains four HEAT repeatsand seven WD-40 repeats; may act as a scaffoldprotein to couple TOR and its effectors 0.077320.24176&radic&radic S000005793HRK1YOR267CverifiedProtein kinase implicated in activation of the plasma membraneH(+)-ATPase Pma1p in response to glucosemetabolism; plays a role in ion homeostasis 0.076680.23992&radic S000002692DPP1YDR284CverifiedDiacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulatedvacuolar membrane-associated lipid phosphatase,dephosphorylates DGPP to phosphatidate (PA) andPi, then PA to diacylglycerol; involved inlipid signaling and cell metabolism 0.075870.23764&radic&radic S000006324CLB5YPR120CverifiedB-type cyclin involved in DNA replication during S phase;activates Cdc28p to promote initiation of DNAsynthesis; functions in formation of mitoticspindles along with Clb3p and Clb4p; mostabundant during late G1 phase 0.075430.23656&radic&radic&radic S000006380BET2YPR176CverifiedBeta subunit of Type II geranylgeranyltransferase required forvesicular transport between the endoplasmicreticulum and the Golgi; provides a membraneattachment moiety to Rab-like proteins Ypt1pand Sec4p 0.075230.23597&radic&radic&radic S000000066SEN34YAR008WverifiedSubunit of the tRNA splicing endonuclease, which is composed ofSen2p, Sen15p, Sen34p, and Sen54p; Sen34pcontains the active site for tRNA 3' splicesite cleavage and has similarity to Sen2p andto Archaeal tRNA splicing endonuclease 0.074790.23454&radic&radic S000001651KKQ8YKL168CverifiedPutative serine/threonine protein kinase with unknown cellularrole 0.074670.23438&radic&radic&radic&radic S000003221RTG2YGL252CverifiedSensor of mitochondrial dysfunction; regulates the subcellularlocation of Rtg1p and Rtg3p, transcriptionalactivators of the retrograde (RTG) and TORpathways; Rtg2p is inhibited by thephosphorylated form of Mks1p &radic0.074280.23338&radic&radic&radic&radic S000002186MPS1YDL028CverifiedDual-specificity kinase required for spindle pole body (SPB)duplication and spindle checkpoint function;substrates include SPB proteins Spc42p,Spc110p, and Spc98p, mitotic exit networkprotein Mob1p, and checkpoint protein Mad1p 0.073770.23168 S000004046ERG3YLR056WverifiedC-5 sterol desaturase, catalyzes the introduction of a C-5(6)double bond into episterol, a precursor inergosterol biosynthesis; mutants are viable,but cannot grow on non-fermentable carbonsources 0.073540.23118&radic&radic&radic S000004886ZDS1YMR273CverifiedProtein that interacts with silencing proteins at the telomere,involved in transcriptional silencing; has arole in localization of Bcy1p, a regulatorysubunit of protein kinase A; implicated in mRNAnuclear export 0.073340.23071&radic&radic&radic&radic&radic S000001654YKL171WUncharacterizedPutative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm 0.073220.23046&radic S000003209DOC1YGL240WverifiedProcessivity factor required for the ubiquitination activity ofthe anaphase promoting complex (APC), mediatesthe activity of the APC by contributing tosubstrate recognition; involved in cyclinproteolysis 0.072820.22957&radic&radic&radic S000004334FKS1YLR342WverifiedCatalytic subunit of 1,3-beta-D-glucan synthase, functionallyredundant with alternate catalytic subunitGsc2p; binds to regulatory subunit Rho1p;involved in cell wall synthesis andmaintenance; localizes to sites of cell wallremodeling 0.072580.22874&radic&radic S000003593IKS1YJL057CuncharacterizedPutative serine/threonine kinase; expression is induced duringmild heat stress; deletion mutants arehypersensitive to copper sulphate and resistantto sorbate; interacts with an N-terminalfragment of Sst2p 0.072490.2284 S000003942KNS1YLL019CverifiedNonessential putative protein kinase of unknown cellular role;member of the LAMMER family of protein kinases,which are serine/threonine kinases also capableof phosphorylating tyrosine residues 0.072260.22791&radic&radic&radic&radic S000004587NGL3YML118WverifiedPutative endonuclease, has a domain similar to amagnesium-dependent endonuclease motif in mRNAdeadenylase Ccr4p; similar to Ngl1p and Ngl2p 0.071890.22689 S000001722YPT52YKR014CverifiedGTPase, similar to Ypt51p and Ypt53p and to mammalian rab5;required for vacuolar protein sorting andendocytosis 0.071560.22595&radic&radic&radic&radic&radic S000005816SNF2YOR290CverifiedCatalytic subunit of the SWI/SNF chromatin remodeling complexinvolved in transcriptional regulation;contains DNA-stimulated ATPase activity;functions interdependently in transcriptionalactivation with Snf5p and Snf6p 0.070850.22394&radic&radic S000002384SHS1YDL225WverifiedOne of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p,Shs1p) that form a cortical filamentous collarat the mother-bud neck which is necessary fornormal morphogenesis and cytokinesis 0.070760.22369&radic S000000595CDC10YCR002CverifiedComponent of the septin ring of the mother-bud neck that isrequired for cytokinesis; septins recruitproteins to the neck and can act as a barrierto diffusion at the membrane, and they comprisethe 10nm filaments seen with EM 0.070750.22369&radic S000001330SEC6YIL068CverifiedEssential 88kDa subunit of the exocyst complex, which mediatespolarized targeting of secretory vesicles toactive sites of exocytosis; dimeric form ofSec6p interacts with Sec9p in vitro andinhibits t-SNARE assembly 0.070690.22361&radic&radic&radic S000000258YRO2YBR054WverifiedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies;transcriptionally regulated by Haa1p 0.070460.22296&radic S000003284FMP48YGR052WuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.07030.22234&radic&radic&radic S000006027SSE1YPL106CverifiedATPase that is a component of the heat shock protein Hsp90chaperone complex; binds unfolded proteins;member of the heat shock protein 70 (HSP70)family; localized to the cytoplasm 0.070230.22222&radic&radic S000002931SPS1YDR523CverifiedPutative protein serine/threonine kinase expressed at the endof meiosis and localized to the prosporemembrane, required for correct localization ofenzymes involved in spore wall synthesis 0.070170.22201&radic S000001101FYV4YHR059WverifiedProtein of unknown function, required for survival uponexposure to K1 killer toxin 0.069720.22093 S000000931SAK1YER129WverifiedUpstream kinase for the SNF1 complex; partially redundantfunction with Elm1p and Tos3p; members of thisfamily of kinases have functional orthologywith LKB1, a mammalian kinase associated withPeutz-Jeghers cancer-susceptibility syndrome 0.069690.22036&radic S000005411GAL11YOL051WverifiedComponent of the Mediator complex; interacts with RNApolymerase II and the general transcriptionfactors to form the RNA polymerase IIholoenzyme; affects transcription by acting astarget of activators and repressors 0.069620.22036&radic&radic S000005237MSB3YNL293WverifiedGTPase-activating protein for Sec4p and several other RabGTPases, regulates exocytosis via its action onSec4p, also required for proper actinorganization; similar to Msb4p; both Msb3p andMsb4p localize to sites of polarized growth 0.069420.21995 S000006007ELP3YPL086CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;exhibits histone acetyltransferase activitythat is directed to histones H3 and H4;disruption confers resistance to K. lactiszymotoxin 0.069310.21971&radic&radic&radic S000002294RDI1YDL135CverifiedRho GDP dissociation inhibitor involved in the localization andregulation of Cdc42p &radic0.069020.2189&radic S000001201KEL1YHR158CverifiedProtein required for proper cell fusion and cell morphology;functions in a complex with Kel2p to negativelyregulate mitotic exit, interacts with Tem1p andLte1p; localizes to regions of polarizedgrowth; potential Cdc28p substrate 0.068780.21821&radic S000006258SMK1YPR054WverifiedMiddle sporulation-specific mitogen-activated protein kinase(MAPK) required for production of the outerspore wall layers; negatively regulatesactivity of the glucan synthase subunit Gsc2p 0.068650.21785 S000001409SLN1YIL147CverifiedHistidine kinase osmosensor that regulates a MAP kinasecascade; transmembrane protein with anintracellular kinase domain that signals toYpd1p and Ssk1p, thereby forming a phosphorelaysystem similar to bacterial two-componentregulators 0.068260.21679&radic S000006315DBF20YPR111WverifiedSer/Thr kinase involved in late nuclear division, one of themitotic exit network (MEN) proteins; necessaryfor the execution of cytokinesis 0.068140.2164&radic&radic&radic S000000399MSI1YBR195CverifiedSubunit of chromatin assembly factor I (CAF-I), regulates theRAS/cAMP pathway via sequestration of Npr1pkinase; localizes to the nucleus and cytoplasm;homologous to human retinoblastoma bindingproteins RbAp48 and RbAp46 &radic0.067570.21501&radic&radic&radic S000005248YPT11YNL304WverifiedRab-type small GTPase that interacts with the C-terminal taildomain of Myo2p to mediate distribution ofmitochondria to daughter cells 0.067540.21493&radic&radic&radic&radic S000001341AIR1YIL079CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p to regulate methylationof Npl3p, which modulates Npl3p function inmRNA processing and export; has similarity toAir2p 0.067510.21485&radic&radic&radic S000003996SSK1YLR006CverifiedCytoplasmic response regulator, part of a two-component signaltransducer that mediates osmosensing via aphosphorelay mechanism; dephosphorylated formis degraded by the ubiquitin-proteasome system;potential Cdc28p substrate 0.067350.21434&radic&radic&radic S000002373PRR2YDL214CverifiedProtein kinase with a possible role in MAP kinase signaling inthe pheromone response pathway &radic0.067290.21411 S000001064YHR022CUncharacterizedPutative protein of unknown function; YHR022C is not an essential gene. 0.067020.21321&radic&radic S000004559GIM5YML094WverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.066710.21246&radic S000006071YPL150WUncharacterizedHypothetical protein 0.066710.21246&radic S000001878MDJ1YFL016CverifiedProtein involved in folding of mitochondrially synthesizedproteins in the mitochondrial matrix; localizesto the mitochondrial inner membrane; member ofthe DnaJ family of molecular chaperones 0.066630.21219 S000004352VPS38YLR360WverifiedPart of a Vps34p phosphatidylinositol 3-kinase complex thatfunctions in carboxypeptidase Y (CPY) sorting;binds Vps30p and Vps34p to promote productionof phosphatidylinositol 3-phosphate (PtdIns3P)which stimulates kinase activity 0.066280.21117&radic&radic&radic S000000777VMA8YEL051WverifiedSubunit D of the eight-subunit V1 peripheral membrane domain ofthe vacuolar H+-ATPase (V-ATPase), anelectrogenic proton pump found throughout theendomembrane system; plays a role in thecoupling of proton transport and ATP hydrolysis 0.066210.21099&radic&radic&radic S000004640MSN2YMR037CverifiedTranscriptional activator related to Msn4p; activated in stressconditions, which results in translocation fromthe cytoplasm to the nucleus; binds DNA atstress response elements of responsive genes,inducing gene expression 0.065420.20887&radic S000001761YSR3YKR053CverifiedDihydrosphingosine 1-phosphate phosphatase, membrane proteininvolved in sphingolipid metabolism; hassimilarity to Lcb3p 0.065010.20761 S000000115APN2YBL019WverifiedClass II abasic (AP) endonuclease involved in repair of DNAdamage; homolog of human HAP1 and E. coliexoIII 0.064910.20737&radic&radic&radic&radic S000002596CCT6YDR188WverifiedSubunit of the cytosolic chaperonin Cct ring complex, relatedto Tcp1p, essential protein that is requiredfor the assembly of actin and tubulins in vivo;contains an ATP-binding motif 0.064730.2068 S000001600SBA1YKL117WverifiedCo-chaperone that binds to and regulates Hsp90 familychaperones; important for pp60v-src activity inyeast; homologous to the mammalian p23 proteins 0.064720.2068&radic&radic&radic&radic&radic S000002510STE5YDR103WverifiedPheromone-responsive scaffold protein; shuttles from thenucleus to the plasma membrane and assembleskinases Ste11p, Ste7p, and Fus3p into aspecific signaling complex; active oligomericform interacts with Ste4p-Ste18p complex 0.064550.2064&radic&radic&radic&radic&radic S000004630TAP42YMR028WverifiedEssential protein involved in the TOR signaling pathway;physically associates with the proteinphosphatase 2A and the SIT4 protein phosphatasecatalytic subunits 0.064260.20549&radic&radic&radic S000003174CHC1YGL206CverifiedClathrin heavy chain, subunit of the major coat proteininvolved in intracellular protein transport andendocytosis; two heavy chains form the clathrintriskelion structural component; the lightchain (CLC1) is thought to regulate function 0.06420.20525 S000002237MRK1YDL079CverifiedGlycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3homologs in S. cerevisiae that function toactivate Msn2p-dependent transcription ofstress responsive genes and that function inprotein degradation 0.06420.20525 S000002616MSS4YDR208WverifiedPhosphatidylinositol-4-phosphate 5-kinase, involved in actincytoskeleton organization and cellmorphogenesis; multicopy suppressor of stt4mutation 0.064020.2047&radic S000003318PIL1YGR086CverifiedPrimary component of eisosomes, which are large immobile patchstructures at the cell cortex associated withendocytosis, along with Lsp1p and Sur7p; nullmutants show activation of Pkc1p/Ypk1p stressresistance pathways 0.063990.20459 S000004015SNF7YLR025WverifiedOne of four subunits of the endosomal sorting complex requiredfor transport III (ESCRT-III); involved in thesorting of transmembrane proteins into themultivesicular body (MVB) pathway; recruitedfrom the cytoplasm to endosomal membranes 0.063650.20376&radic&radic&radic S000006157YPL236CUncharacterizedHypothetical protein 0.063520.20337 S000001599PRR1YKL116CverifiedProtein kinase with a possible role in MAP kinase signaling inthe pheromone response pathway &radic0.063510.2033&radic&radic&radic S000003701HAL5YJL165CverifiedPutative protein kinase; overexpression increases sodium andlithium tolerance, whereas gene disruptionincreases cation and low pH sensitivity andimpairs potassium uptake, suggesting a role inregulation of Trk1p and/or Trk2p transporters 0.063440.20299 S000003217PDE1YGL248WverifiedLow-affinity cyclic AMP phosphodiesterase, controls glucose andintracellular acidification-induced cAMPsignaling, target of the cAMP-protein kinase A(PKA) pathway; glucose induces transcriptionand inhibits translation &radic0.063390.20299&radic&radic&radic S000002299RPO21YDL140CverifiedRNA polymerase II largest subunit B220, part of central core;phosphorylation of C-terminal heptapeptiderepeat domain regulates association withtranscription and splicing factors; similar tobacterial beta-prime 0.06280.20133 S000003850GRR1YJR090CverifiedF-box protein component of the SCF ubiquitin-ligase complex,required for Cln1p and Cln2p degradation;involved in carbon catabolite repression,glucose-dependent divalent cation transport,high-affinity glucose transport, andmorphogenesis 0.062770.20108 S000001118PTC7YHR076WverifiedMitochondrially localized type 2C protein phosphatase;expression induced by growth on ethanol and bysustained osmotic stress; possible role incarbon source utilization in low oxygenenvironments 0.062770.20108&radic&radic&radic S000000925YCK3YER123WverifiedPalmitoylated, vacuolar membrane-localized casein kinase Iisoform; negatively regulates vacuole fusionduring hypertonic stress via phosphorylation ofthe HOPS complex subunit, Vps41p; sharesoverlapping essential functions with Hrr25p 0.06270.20097 S000002320ENT1YDL161WverifiedEpsin-like protein involved in endocytosis and actin patchassembly and functionally redundant with Ent2p;binds clathrin via a clathrin-binding domainmotif at C-terminus 0.062490.20029 S000003693FAR1YJL157CverifiedCyclin-dependent kinase inhibitor that mediates cell cyclearrest in response to pheromone; also forms acomplex with Cdc24p, Ste4p, and Ste18p that mayspecify the direction of polarized growthduring mating; potential Cdc28p substrate 0.06240.19991&radic&radic S000004378VAC14YLR386WverifiedProtein involved in regulated synthesis of PtdIns(3,5)P(2), incontrol of trafficking of some proteins to thevacuole lumen via the MVB, and in maintenanceof vacuole size and acidity; activator of Fab1p 0.062060.19901&radic&radic S000000451ENP1YBR247CverifiedProtein associated with U3 and U14 snoRNAs, required forpre-rRNA processing and 40S ribosomal subunitsynthesis; localized in the nucleus andconcentrated in the nucleolus 0.061810.19816&radic&radic&radic S000005008YDJ1YNL064CverifiedProtein chaperone involved in regulation of the HSP90 and HSP70functions; involved in protein translocationacross membranes; member of the DnaJ family 0.061780.19803&radic S000004156SEC10YLR166CverifiedEssential 100kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which has the essential function ofmediating polarized targeting of secretoryvesicles to active sites of exocytosis 0.061590.19746&radic&radic&radic S000000069BUD14YAR014CverifiedProtein involved in bud-site selection, Bud14p-Glc7p complexfunctions as a cortical regulator of dynein;diploid mutants display a random buddingpattern instead of the wild-type bipolarpattern 0.061160.19606&radic&radic&radic S000001001YAP3YHL009CverifiedBasic leucine zipper (bZIP) transcription factor 0.060990.19573&radic&radic&radic&radic S000003123CDC43YGL155WverifiedBeta subunit of geranylgeranyltransferase type I, catalyzesgeranylgeranylation to the cysteine residue inproteins containing a C-terminal CaaX sequenceending in Leu or Phe; has substrates importantfor morphogenesis &radic0.060860.1954&radic S000002205SIT4YDL047WverifiedType 2A-related serine-threonine phosphatase that functions inthe G1/S transition of the mitotic cycle;cytoplasmic and nuclear protein that modulatesfunctions mediated by Pkc1p including cell walland actin cytoskeleton organization &radic0.060810.1953&radic S000000935GLC7YER133WverifiedCatalytic subunit of type 1 serine/threonine proteinphosphatase, involved in many processesincluding glycogen metabolism, sporulation, andmitosis; interacts with multiple regulatorysubunits; predominantly isolated with Sds22p 0.060640.19474&radic S000002290CDC53YDL132WverifiedCullin, structural protein of SCF complexes (which also containSkp1p, Cdc34p, and an F-box protein) involvedin ubiquitination; SCF promotes the G1-Stransition by targeting G1 cyclins and theCln-CDK inhibitor Sic1p for degradation 0.060630.1947&radic S000002874PKH3YDR466WverifiedProtein kinase with similarity to mammalianphosphoinositide-dependent kinase 1 (PDK1) andyeast Pkh1p and Pkh2p, two redundant upstreamactivators of Pkc1p; identified as a multicopysuppressor of a pkh1 pkh2 double mutant &radic0.060050.19303 S000004798HSC82YMR186WverifiedCytoplasmic chaperone of the Hsp90 family, redundant infunction and nearly identical with Hsp82p, andtogether they are essential; expressedconstitutively at 10-fold higher basal levelsthat HSP82 and induced 2-3 fold by heat shock 0.059740.19214&radic&radic&radic S000005132KAR1YNL188WverifiedEssential protein involved in karyogamy during mating and inspindle pole body duplication during mitosis,localizes to the half-bridge of the spindlepole body, interacts with Spc72p duringkaryogamy, also interacts with Cdc31p 0.059630.19189&radic&radic&radic S000004106MSL5YLR116WverifiedComponent of the commitment complex, which defines the firststep in the splicing pathway; essential proteinthat interacts with Mud2p and Prp40p, forming abridge between the intron ends; also involvedin nuclear retention of pre-mRNA 0.059590.19178&radic&radic S000000818BIM1YER016WverifiedMicrotubule-binding protein that together with Kar9p makes upthe cortical microtubule capture site anddelays the exit from mitosis when the spindleis oriented abnormally 0.059050.19013&radic S000006082BEM4YPL161CverifiedProtein involved in establishment of cell polarity and budemergence; interacts with the Rho1p smallGTP-binding protein and with the Rho-typeGTPase Cdc42p; involved in maintenance ofproper telomere length &radic0.059020.19013&radic&radic S000002275CYK3YDL117WverifiedSH3-domain protein located in the mother-bud neck and thecytokinetic actin ring; mutant phenotype andgenetic interactions suggest a role incytokinesis 0.058820.18949&radic S000003310PAC10YGR078CverifiedPart of the heteromeric co-chaperone GimC/prefoldin complex,which promotes efficient protein folding 0.058820.18949&radic&radic&radic&radic S000003966FPS1YLL043WverifiedPlasma membrane glycerol channel, member of the major intrinsicprotein (MIP) family of channel proteins;involved in efflux of glycerol and in uptake ofthe trivalent metalloids arsenite andantimonite 0.058620.18885&radic&radic&radic&radic&radic S000005187SLA2YNL243WverifiedTransmembrane actin-binding protein involved in membranecytoskeleton assembly and cell polarization;adaptor protein that links actin to clathrinand endocytosis; present in the actin corticalpatch of the emerging bud tip; dimer in vivo 0.058520.18847&radic S000003349YGR117CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.058240.18778&radic S000005897MRS6YOR370CverifiedRab escort protein, forms a complex with the Ras-like smallGTPase Ypt1p that is required for theprenylation of Ypt1p by proteingeranylgeranyltransferase type II (Bet2p-Bet4p) 0.058220.18771&radic&radic&radic&radic&radic S000000895TSC11YER093CverifiedSubunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), amembrane-associated complex that regulatesactin cytoskeletal dynamics during polarizedgrowth and cell wall integrity; involved insphingolipid metabolism; contains a RasGEFNdomain 0.058180.18747 S000002487VPS41YDR080WverifiedVacuolar membrane protein that is a subunit of the homotypicvacuole fusion and vacuole protein sorting(HOPS) complex; essential for membrane dockingand fusion at the Golgi-to-endosome andendosome-to-vacuole stages of protein transport 0.057840.18642&radic&radic S000006375BSP1YPR171WverifiedAdapter that links synaptojanins Inp52p and Inp53p to thecortical actin cytoskeleton 0.057750.18621&radic&radic S000001249SKN7YHR206WverifiedNuclear response regulator and transcription factor, part of abranched two-component signaling system;required for optimal induction of heat-shockgenes in response to oxidative stress; involvedin osmoregulation 0.057730.18618&radic S000001681PTK1YKL198CverifiedPutative serine/threonine protein kinase that regulatesspermine uptake; involved in polyaminetransport; possible mitochondrial protein 0.057690.18606&radic&radic&radic S000000842GLN3YER040WverifiedTranscriptional activator of genes regulated by nitrogencatabolite repression (NCR), localization andactivity regulated by quality of nitrogensource 0.057320.18488&radic&radic&radic&radic&radic S000002533SWF1YDR126WverifiedPalmitoyltransferase that acts on the SNAREs Snc1p, Syn8p,Tlg1p and likely on all SNAREs; member of afamily of putative palmitoyltransferasescontaining an Asp-His-His-Cys-cysteine rich(DHHC-CRD) domain; may have a role in vacuolefusion 0.057050.18397&radic S000004992SLM2YNL047CverifiedPhosphoinositide PI4,5P(2) binding protein, forms a complexwith Slm1p; acts downstream of Mss4p in apathway regulating actin cytoskeletonorganization in response to stress; subunit ofand phosphorylated by the TORC2 complex 0.056830.1833 S000006323CLB2YPR119WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the transition from G2 to Mphase; accumulates during G2 and M, thentargeted via a destruction box motif forubiquitin-mediated degradation by theproteasome 0.056720.18306&radic&radic&radic S000002394YPD1YDL235CverifiedPhosphorelay intermediate protein, phosphorylated by the plasmamembrane sensor Sln1p in response to osmoticstress and then in turn phosphorylates theresponse regulators Ssk1p in the cytosol andSkn7p in the nucleus 0.05670.18298&radic S000002911LPP1YDR503CverifiedLipid phosphate phosphatase, catalyzes Mg(2+)-independentdephosphorylation of phosphatidic acid (PA),lysophosphatidic acid, and diacylglycerolpyrophosphate; involved in control of thecellular levels of phosphatidylinositol and PA 0.056550.18259 S000004972CRZ1YNL027WverifiedTranscription factor that activates transcription of genesinvolved in stress response; nuclearlocalization is positively regulated bycalcineurin-mediated dephosphorylation &radic0.056470.18242&radic S000003837CDC11YJR076CverifiedComponent of the septin ring of the mother-bud neck that isrequired for cytokinesis; septins recruitproteins to the neck and can act as a barrierto diffusion at the membrane, and they comprisethe 10nm filaments seen with EM 0.056280.18184 S000000927RSP5YER125WverifiedUbiquitin-protein ligase involved in ubiquitin-mediated proteindegradation; plays a role in heat shock element(HSE)-mediated gene expression andmultivesicular body sorting; contains a hect(homologous to E6-AP carboxyl terminus) domain 0.05610.18138 S000002705SUR2YDR297WverifiedSphinganine C4-hydroxylase, catalyses the conversion ofsphinganine to phytosphingosine in sphingolipidbiosyntheis 0.055980.18111&radic&radic S000001065MYO1YHR023WverifiedType II myosin heavy chain, required for wild-type cytokinesisand cell separation; localizes to theactomyosin ring; binds to myosin light chainsMlc1p and Mlc2p through its IQ1 and IQ2 motifsrespectively 0.0560.18111 S000003470KEL2YGR238CverifiedProtein that functions in a complex with Kel1p to negativelyregulate mitotic exit, interacts with Tem1p andLte1p; localizes to regions of polarizedgrowth; potential Cdc28p substrate 0.055940.18098&radic S000001762DYN1YKR054CverifiedCytoplasmic heavy chain dynein, microtubule motor protein,required for anaphase spindle elongation;involved in spindle assembly, chromosomemovement, and spindle orientation during celldivision, targeted to microtubule tips by Pac1p 0.055750.18031&radic&radic&radic&radic&radic S000006130IPL1YPL209CverifiedAurora kinase involved in regulating kinetochore-microtubuleattachments; helps maintain condensedchromosomes during anaphase and earlytelophase; associates with Sli15p, whichpromotes Ipl1p association with mitotic spindle 0.055510.17959&radic&radic&radic&radic S000002728SWA2YDR320CverifiedAuxilin-like protein involved in vesicular transport;clathrin-binding protein required for uncoatingof clathrin-coated vesicles 0.055370.17927&radic&radic S000000433ROT2YBR229CverifiedGlucosidase II catalytic subunit required for normal cell wallsynthesis; mutations in rot2 suppress tor2mutations, and are synthetically lethal withrot1 mutations 0.055190.17881&radic&radic&radic S000002831CAD1YDR423CverifiedAP-1-like bZIP transcriptional activator involved in multiplestress responses, iron metabolism, andpleiotropic drug resistance; controls a set ofgenes involved in stabilizing proteins, bindsconsensus sequence TTACTAA; 5' UTR containsuORFs 0.055050.17837&radic&radic&radic S000003461SMI1YGR229CverifiedProtein involved in the regulation of cell wall synthesis;proposed to be involved in coordinating cellcycle progression with cell wall integrity 0.055030.17833&radic&radic S000006387DPM1YPR183WverifiedDolichol phosphate mannose (Dol-P-Man) synthase of the ERmembrane, catalyzes the formation of Dol-P-Manfrom Dol-P and GDP-Man; required for glycosylphosphatidylinositol membrane anchoring, Omannosylation, and protein glycosylation 0.054990.1782&radic S000004080XDJ1YLR090WverifiedPutative chaperone, homolog of E. coli DnaJ, closely related toYdj1p; the authentic, non-tagged protein isdetected in highly purified mitochondria inhigh-throughput studies 0.054860.17778&radic S000003598LAS21YJL062WverifiedIntegral plasma membrane protein involved in the synthesis ofthe glycosylphosphatidylinositol (GPI) corestructure; mutations affect cell wall integrity 0.054760.1775 S000003003MIG1YGL035CverifiedTranscription factor involved in glucose repression; C2H2 zincfinger protein similar to mammalian Egr andWilms tumor proteins 0.054680.17726&radic S000006112YPL191CUncharacterizedHypothetical protein 0.054650.17722&radic&radic&radic S000002936HLR1YDR528WverifiedProtein involved in regulation of cell wall composition andintegrity and response to osmotic stress;overproduction suppresses a lysis sensitive PKCmutation; similar to Lre1p, which functionsantagonistically to protein kinase A 0.05460.1771&radic S000000529KCC4YCL024WverifiedProtein kinase of the bud neck involved in the septincheckpoint, associates with septin proteins,negatively regulates Swe1p by phosphorylation,shows structural homology to bud neck kinasesGin4p and Hsl1p 0.05430.17638&radic&radic&radic&radic S000003854IME1YJR094CverifiedMaster regulator of meiosis that is active only during meioticevents, activates transcription of earlymeiotic genes through interaction with Ume6p,degraded by the 26S proteasome followingphosphorylation by Ime2p 0.054260.17621 S000004372CSR1YLR380WverifiedPhosphatidylinositol transfer protein with a potential role inlipid turnover; interacts specifically withthioredoxin peroxidase (Tsa2p) and may have arole in oxidative stress resistance 0.054210.17611&radic&radic&radic&radic S000001534SFK1YKL051WverifiedPlasma membrane protein that may act together with or upstreamof Stt4p to generate normal levels of theessential phospholipid PI4P, at least partiallymediates proper localization of Stt4p to theplasma membrane &radic0.054140.17596&radic&radic S000003486ENO1YGR254WverifiedEnolase I, a phosphopyruvate hydratase that catalyzes theconversion of 2-phosphoglycerate tophosphoenolpyruvate during glycolysis and thereverse reaction during gluconeogenesis;expression is repressed in response to glucose 0.054060.1756&radic S000001873GAT1YFL021WverifiedTranscriptional activator of genes involved in nitrogencatabolite repression, member of the GATAfamily of DNA binding proteins; activity andlocalization regulated by nitrogen limitationand Ure2p 0.053990.17554&radic&radic&radic&radic S000005151RIO2YNL207WverifiedEssential serine kinase involved in the processing of the 20Spre-rRNA into mature 18S rRNA; has similarityto Rio1p 0.053640.17445&radic&radic&radic&radic S000002461CDC34YDR054CverifiedUbiquitin-conjugating enzyme or E2; together with Skp1p, Rbx1p,Cdc53p, and an F-box protein, forms aubiquitin-protein ligase called the SCF complexwhich regulates cell cycle progression bytargeting key substrates for degradation 0.053550.17407&radic&radic&radic&radic&radic S000005405PSK2YOL045WverifiedOne of two (see also PSK1) PAS domain containing S/T proteinkinases; regulates sugar flux and translationin response to an unknown metabolite byphosphorylating Ugp1p and Gsy2p (sugar flux)and Caf20p, Tif11p and Sro9p (translation) 0.053540.17407&radic&radic&radic&radic S000005707LAS17YOR181WverifiedActin assembly factor, activates the Arp2/3 protein complexthat nucleates branched actin filaments;localizes with the Arp2/3 complex to actinpatches; homolog of the human Wiskott-Aldrichsyndrome protein (WASP) 0.053380.17371&radic S000000028SNC1YAL030WverifiedVesicle membrane receptor protein (v-SNARE) involved in thefusion between Golgi-derived secretory vesicleswith the plasma membrane; proposed to beinvolved in endocytosis; member of thesynaptobrevin/VAMP family of R-type v-SNAREproteins 0.053270.17348&radic&radic&radic S000000532FUS1YCL027WverifiedMembrane protein localized to the shmoo tip, required for cellfusion; expression regulated by matingpheromone; proposed to coordinate signaling,fusion, and polarization events required forfusion; potential Cdc28p substrate 0.053090.17294&radic&radic S000002667YAP6YDR259CverifiedPutative basic leucine zipper (bZIP) transcription factor;overexpression increases sodium and lithiumtolerance 0.053090.17294&radic&radic&radic S000003084CDC20YGL116WverifiedCell-cycle regulated activator of anaphase-promotingcomplex/cyclosome (APC/C), which is requiredfor metaphase/anaphase transition; directsubiquitination of mitotic cyclins, Pds1p, andother anaphase inhibitors; potential Cdc28psubstrate 0.0530.17266&radic S000002180GPD1YDL022WverifiedNAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme ofglycerol synthesis, essential for growth underosmotic stress; expression regulated byhigh-osmolarity glycerol response pathway;homolog of Gpd2p 0.052980.17262 S000001126STE12YHR084WverifiedTranscription factor that is activated by a MAP kinasesignaling cascade, activates genes involved inmating or pseudohyphal/invasive growthpathways; cooperates with Tec1p transcriptionfactor to regulate genes specific for invasivegrowth 0.052950.17252 S000004635HOF1YMR032WverifiedBud neck-localized, SH3 domain-containing protein required forcytokinesis; regulates actomyosin ring dynamicsand septin localization; interacts with theformins, Bni1p and Bnr1p, and with Cyk3p,Vrp1p, and Bni5p 0.052910.17237&radic&radic S000006363KRE6YPR159WverifiedProtein required for beta-1,6 glucan biosynthesis; putativebeta-glucan synthase; appears functionallyredundant with Skn1p 0.052740.17191&radic S000001195SPO12YHR152WverifiedNucleolar protein of unknown function, positive regulator ofexit from mitosis; involved in regulating therelease of Cdc14p from the nucleolus in earlyanaphase; proposed to play similar role inmeiosis 0.052560.17123&radic&radic S000005274RPD3YNL330CverifiedHistone deacetylase; regulates transcription and silencing 0.05250.17099&radic&radic&radic S000005207YIF1YNL263CverifiedIntegral membrane protein required for the fusion of ER-derivedCOPII transport vesicles with the Golgi;interacts with Yip1p and Yos1p; localizes tothe Golgi, the ER, and COPII vesicles 0.052390.17066&radic&radic&radic S000000729GIM4YEL003WverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.052130.17003&radic&radic&radic S000002178RPN4YDL020CverifiedTranscription factor that stimulates expression of proteasomegenes; Rpn4p levels are in turn regulated bythe 26S proteasome in a negative feedbackcontrol mechanism; RPN4 is transcriptionallyregulated by various stress responses 0.051940.16943&radic S000002418SNQ2YDR011WverifiedABC transporter protein involved in multidrug resistance andresistance to singlet oxygen species 0.051910.16943 S000003634SAP185YJL098WverifiedProtein that forms a complex with the Sit4p protein phosphataseand is required for its function; member of afamily of similar proteins including Sap4p,Sap155p, and Sap190p 0.051880.16932&radic S000000760HYP2YEL034WverifiedTranslation initiation factor eIF-5A, promotes formation of thefirst peptide bond; similar to and functionallyredundant with Anb1p; possible role intranslation elongation; undergoes an essentialhypusination modification 0.051080.1666 S000005759KIN4YOR233WverifiedKinase that acts by inhibiting the mitotic exit network (MEN)when the spindle position checkpoint isactivated; localized asymmetrically to mothercell cortex, spindle pole body and bud neck 0.051080.1666&radic S000001298CST6YIL036WverifiedBasic leucine zipper (bZIP) transcription factor of theATF/CREB family, activates transcription ofgenes involved in utilization of non-optimalcarbon sources; involved in telomeremaintenance 0.050990.16649&radic&radic&radic S000002987CKB1YGL019WverifiedBeta regulatory subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKA2 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.050940.16612&radic&radic&radic S000005402NGL1YOL042WverifiedPutative endonuclease, has a domain similar to amagnesium-dependent endonuclease motif in mRNAdeadenylase Ccr4p; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.05090.16612&radic&radic&radic S000002918SMT3YDR510WverifiedUbiquitin-like protein of the SUMO family, conjugated to lysineresidues of target proteins; regulateschromatid cohesion, chromosome segregation,APC-mediated proteolysis, DNA replication andseptin ring dynamics 0.050820.16597&radic S000006131SRP72YPL210CverifiedCore component of the signal recognition particle (SRP)ribonucleoprotein (RNP) complex that functionsin targeting nascent secretory proteins to theendoplasmic reticulum (ER) membrane 0.050850.16597&radic&radic&radic S000004376IKI3YLR384CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;maintains structural integrity of Elongator;homolog of human IKAP, mutations in which causefamilial dysautonomia (FD) 0.050770.16584&radic&radic&radic S000000157SKT5YBL061CverifiedActivator of Chs3p (chitin synthase III), recruits Chs3p to thebud neck via interaction with Bni4p; hassimilarity to Shc1p, which activates Chs3pduring sporulation 0.050630.16552&radic&radic&radic&radic S000003394TIF4631YGR162WverifiedTranslation initiation factor eIF4G, subunit of the mRNAcap-binding protein complex (eIF4F) that alsocontains eIF4E (Cdc33p); associates with thepoly(A)-binding protein Pab1p, also interactswith eIF4A (Tif1p); homologous to Tif4632p 0.05050.1652&radic S000004345BUD8YLR353WverifiedProtein involved in bud-site selection; diploid mutants displaya unipolar budding pattern instead of thewild-type bipolar pattern, and bud at theproximal pole 0.050310.16461&radic&radic S000004849TAF9YMR236WverifiedSubunit (17 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification, similar to histone H3 0.050350.16461&radic&radic&radic S000002672AKR1YDR264CverifiedPalmitoyl transferase involved in protein palmitoylation; actsas a negative regulator of pheromone responsepathway; required for endocytosis of pheromonereceptors; involved in cell shape control;contains ankyrin repeats 0.050350.16461&radic&radic S000002488PDC2YDR081CverifiedTranscription factor required for the synthesis of theglycolytic enzyme pyruvate decarboxylase,required for high level expression of both theTHI and the PDC genes 0.050280.1645&radic&radic&radic&radic S000003900HOM6YJR139CverifiedHomoserine dehydrogenase (L-homoserine:NADP oxidoreductase),dimeric enzyme that catalyzes the third step inthe common pathway for methionine and threoninebiosynthesis; enzyme has nucleotide-binding,dimerization and catalytic regions 0.05020.16428&radic S000001457YAP5YIR018WverifiedBasic leucine zipper (bZIP) transcription factor 0.050130.16404&radic&radic S000002674YDR266CUncharacterizedHypothetical protein 0.050110.16394&radic&radic&radic&radic&radic S000004905YMR291WUncharacterizedPutative kinase of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR291W is not an essential gene 0.050020.16378&radic&radic&radic&radic S000001728VPS51YKR020WverifiedComponent of the GARP (Golgi-associated retrograde protein)complex, Vps51p-Vps52p-Vps53p-Vps54p, which isrequired for the recycling of proteins fromendosomes to the late Golgi; links the(VFT/GARP) complex to the SNARE Tlg1p 0.04990.16337&radic&radic&radic&radic&radic S000005982ALD6YPL061WverifiedCytosolic aldehyde dehydrogenase, activated by Mg2+ andutilizes NADP+ as the preferred coenzyme;required for conversion of acetaldehyde toacetate; constitutively expressed; locates tothe mitochondrial outer surface upon oxidativestress 0.049790.16303&radic&radic S000004478PPZ1YML016CverifiedSerine/threonine protein phosphatase Z, isoform of Ppz2p;involved in regulation of potassium transport,which affects osmotic stability, cell cycleprogression, and halotolerance 0.049350.16139&radic&radic&radic&radic&radic S000000605PGK1YCR012Wverified3-phosphoglycerate kinase, catalyzes transfer of high-energyphosphoryl groups from the acyl phosphate of1,3-bisphosphoglycerate to ADP to produce ATP;key enzyme in glycolysis and gluconeogenesis 0.049330.16139&radic&radic&radic S000004168TFS1YLR178CverifiedCarboxypeptidase Y inhibitor, function requires acetylation bythe NatB N-terminal acetyltransferase;phosphatidylethanolamine-binding proteininvolved in protein kinase A signaling pathway 0.049340.16139&radic&radic&radic S000001055ARD1YHR013CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.049320.16139&radic&radic&radic&radic S000005299ACC1YNR016CverifiedAcetyl-CoA carboxylase, biotin containing enzyme that catalyzesthe carboxylation of acetyl-CoA to formmalonyl-CoA; required for de novo biosynthesisof long-chain fatty acids 0.049120.16079&radic&radic&radic&radic&radic&radic S000002218TSR1YDL060WverifiedProtein required for processing of 20S pre-rRNA in thecytoplasm, associates with pre-40S ribosomalparticles 0.049060.16069&radic S000003030PYC1YGL062WverifiedPyruvate carboxylase isoform, cytoplasmic enzyme that convertspyruvate to oxaloacetate; highly similar toisoform Pyc2p but differentially regulated;mutations in the human homolog are associatedwith lactic acidosis 0.049040.16052&radic&radic S000002503GIS1YDR096WverifiedTranscriptional factor, involved in the expression of genesduring nutrient limitation; also involved inthe negative regulation of DPP1 and PHR1 0.048980.16037&radic&radic S000005976LGE1YPL055CverifiedProtein of unknown function; null mutant forms abnormally largecells 0.04890.16018&radic&radic&radic&radic S000000969BCK2YER167WverifiedProtein rich in serine and threonine residues involved inprotein kinase C signaling pathway, whichcontrols cell integrity; overproductionsuppresses pkc1 mutations 0.048870.16007&radic S000002691GCN2YDR283CverifiedProtein kinase, phosphorylates the alpha-subunit of translationinitiation factor eIF2 (Sui2p) in response tostarvation; activated by uncharged tRNAs andthe Gcn1p-Gcn20p complex 0.048780.15976&radic&radic&radic S000005469ZEO1YOL109WverifiedPeripheral membrane protein of the plasma membrane thatinteracts with Mid2p; regulates the cellintegrity pathway mediated by Pkc1p and Slt2p 0.048690.15957 S000004140STM1YLR150WverifiedProtein that binds G4 quadruplex and purine motif triplexnucleic acid; acts with Cdc13p to maintaintelomere structure; interacts with ribosomesand subtelomeric Y' DNA; multicopy suppressorof tom1 and pop2 mutations 0.048480.15888&radic&radic&radic&radic S000001367SLM1YIL105CverifiedPhosphoinositide PI4,5P(2) binding protein, forms a complexwith Slm2p; acts downstream of Mss4p in apathway regulating actin cytoskeletonorganization in response to stress; subunit ofand phosphorylated by the TORC2 complex 0.048130.15768 S000005335POP2YNR052CverifiedRNase of the DEDD superfamily, subunit of the Ccr4-Not complexthat mediates 3' to 5' mRNA deadenylation 0.048110.15768&radic S000001936SAP155YFR040WverifiedProtein that forms a complex with the Sit4p protein phosphataseand is required for its function; member of afamily of similar proteins including Sap4p,Sap185p, and Sap190p 0.047860.15685&radic&radic&radic S000001234CTF8YHR191CverifiedSubunit of a complex with Ctf18p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion 0.047790.15661 S000005574RAT1YOR048CverifiedNuclear 5' to 3' single-stranded RNA exonuclease, involved inRNA metabolism, including rRNA and snRNAprocessing as well as mRNA transcriptiontermination 0.047750.15648&radic&radic S000004069SIC1YLR079WverifiedInhibitor of Cdc28-Clb kinase complexes that controls G1/Sphase transition, preventing premature S phaseand ensuring genomic integrity; phosphorylationtargets Sic1p for SCF(CDC4)-dependent turnover;functional homolog of mammalian Kip1 0.047710.1564&radic&radic&radic&radic&radic S000000847ACA1YER045CverifiedBasic leucine zipper (bZIP) transcription factor of theATF/CREB family, may regulate transcription ofgenes involved in utilization of non-optimalcarbon sources 0.047480.15559&radic&radic&radic S000004684SEC14YMR079WverifiedPhosphatidylinositol/phosphatidylcholine transfer proteininvolved in coordinate regulation of PtdIns andPtdCho metabolism, products of which areregulators in Golgi to plasma membranetransport; functionally homologous to mammalianPITPs 0.047460.15559&radic S000001859MOB2YFL034C-BverifiedComponent of the RAM signaling network, localizes and activatesthe Ace2p in the daughter cell nucleus todirect daughter cell-specific transcription ofseveral genes involved in cell separation;Mob1p-like protein 0.047370.15502&radic&radic&radic&radic&radic&radic S000006339CTF4YPR135WverifiedChromatin-associated protein, required for sister chromatidcohesion; interacts with DNA polymerase alpha(Pol1p) and may link DNA synthesis to sisterchromatid cohesion 0.047250.15485&radic S000000240CSG2YBR036CverifiedEndoplasmic reticulum membrane protein, required formannosylation of inositolphosphorylceramide andfor growth at high calcium concentrations 0.047140.15435 S000004342ORM2YLR350WverifiedEvolutionarily conserved protein with similarity to Orm1p,required for resistance to agents that inducethe unfolded protein response; human orthologis located in the endoplasmic reticulum 0.047160.15435&radic&radic&radic S000003041HSF1YGL073WverifiedTrimeric heat shock transcription factor, activates multiplegenes in response to stresses that includehyperthermia; recognizes variable heat shockelements (HSEs) consisting of inverted NGAANrepeats; posttranslationally regulated 0.047060.15413&radic&radic S000004391BDF1YLR399CverifiedProtein involved in transcription initiation at TATA-containingpromoters; associates with the basaltranscription factor TFIID; contains twobromodomains; corresponds to the C-terminalregion of mammalian TAF1; redundant with Bdf2p 0.04710.15413&radic&radic&radic&radic S000002856ADA2YDR448WverifiedTranscription coactivator, component of the ADA and SAGAtranscriptional adaptor/HAT (histoneacetyltransferase) complexes 0.047020.15403 S000002702DPL1YDR294CverifiedDihydrosphingosine phosphate lyase, regulates intracellularlevels of sphingolipid long-chain basephosphates (LCBPs), degrades phosphorylatedlong chain bases, prefers C16dihydrosphingosine-l-phosphate as a substrate &radic0.046990.15394&radic&radic&radic&radic S000003472PFK1YGR240CverifiedAlpha subunit of heterooctameric phosphofructokinase involvedin glycolysis, indispensable for anaerobicgrowth, activated by fructose-2,6-bisphosphateand AMP, mutation inhibits glucose induction ofcell cycle-related genes 0.046850.15342&radic&radic&radic&radic&radic S000005583SGT1YOR057WverifiedProbable cochaperone, regulates activity of Cyr1p (adenylylcyclase); involved in assembly of thekinetochore complex, associates with the SCF(Skp1p/Cdc53p/F box protein) ubiquitin ligasecomplex &radic0.046570.15257&radic&radic&radic&radic&radic&radic S000003083SNF4YGL115WverifiedProtein kinase activator found in a complex containing Snf1pand members of the Sip1p/Sip2p/Gal83p family;activates the Snf1p protein kinase; involved inexpression of glucose-repressed genes,sporulation, and peroxisome biogenesis 0.046340.15183&radic S000000021PMT2YAL023CverifiedProtein O-mannosyltransferase, transfers mannose residues fromdolichyl phosphate-D-mannose to proteinserine/threonine residues; acts in a complexwith Pmt1p, can instead interact with Pmt5p insome conditions; target for new antifungals 0.04630.15173&radic S000002187ARP2YDL029WverifiedEssential component of the Arp2/3 complex, which is a highlyconserved actin nucleation center required forthe motility and integrity of actin patches;involved in endocytosis and membrane growth andpolarity 0.046280.15163 S000007253MBF1YOR298C-AverifiedTranscriptional coactivator that bridges the DNA-binding regionof Gcn4p and TATA-binding protein Spt15p;suppressor of frameshift mutations 0.046210.15138&radic S000003682IDS2YJL146WverifiedProtein involved in modulation of Ime2p activity duringmeiosis, appears to act indirectly to promoteIme2p-mediated late meiotic functions; found ingrowing cells and degraded during sporulation 0.046150.15132&radic&radic&radic&radic S000004813ROT1YMR200WverifiedEssential ER membrane protein; may be involved in proteinfolding; mutation causes defects in cell wallsynthesis and in lysis of autophagic bodies,suppresses tor2 mutations, and is syntheticallylethal with kar2-1 and with rot2 mutations 0.045880.1504&radic&radic&radic&radic S000004683CTF18YMR078CverifiedSubunit of a complex with Ctf8p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion; may have overlappingfunctions with Rad24p in the DNA damagereplication checkpoint 0.045710.14991&radic S000001556LHS1YKL073WverifiedMolecular chaperone of the endoplasmic reticulum lumen,involved in polypeptide translocation andfolding; member of the Hsp70 family; localizesto the lumen of the ER; regulated by theunfolded protein response pathway 0.045570.14949 S000002800SPT3YDR392WverifiedSubunit of the SAGA and SAGA-like transcriptional regulatorycomplexes, interacts with Spt15p to activatetranscription of some RNA polymeraseII-dependent genes, also functions to inhibittranscription at some promoters 0.045480.14914&radic S000003689INO1YJL153CverifiedInositol 1-phosphate synthase, involved in synthesis ofinositol phosphates and inositol-containingphospholipids; transcription is coregulatedwith other phospholipid biosynthetic genes byIno2p and Ino4p, which bind the UASINO DNAelement 0.045440.14904&radic&radic&radic S000002995CWH41YGL027CverifiedProcessing alpha glucosidase I, ER type II integral membraneN-glycoprotein involved in assembly of cellwall beta 1,6 glucan and asparagine-linkedprotein glycosylation; also involved in ERprotein quality control and sensing of ERstress 0.045420.14896&radic&radic S000004467ERG6YML008CverifiedDelta(24)-sterol C-methyltransferase, converts zymosterol tofecosterol in the ergosterol biosyntheticpathway by methylating position C-24; localizedto both lipid particles and mitochondrial outermembrane 0.045370.14885&radic&radic&radic S000004715MYO5YMR109WverifiedOne of two type I myosins; contains proline-rich tail homology2 (TH2) and SH3 domains; MYO5 deletion haslittle effect on growth, but myo3 myo5 doubledeletion causes severe defects in growth andactin cytoskeleton organization 0.045320.14859 S000005180SIN4YNL236WverifiedSubunit of the Mediator complex; interacts with the RNApolymerase II holoenzyme to postively ornegatively regulate transcription; dispensiblefor basal transcription 0.045120.14798&radic&radic&radic S000006222RLF2YPR018WverifiedLargest subunit (p90) of the Chromatin Assembly Complex (CAF-I)with Cac2p and Msi1p that assembles newlysynthesized histones onto recently replicatedDNA; involved in the maintenance oftranscriptionally silent chromatin 0.045040.14771 S000003393RTS3YGR161CuncharacterizedPutative component of the protein phosphatase type 2A complex 0.045030.14771&radic&radic S000003804POL32YJR043CverifiedThird subunit of DNA polymerase delta, involved in chromosomalDNA replication; required for error-prone DNAsynthesis in the presence of DNA damage andprocessivity; interacts with Hys2p, PCNA(Pol30p), and Pol1p 0.045050.14771&radic S000002296ARF2YDL137WverifiedADP-ribosylation factor, GTPase of the Ras superfamily involvedin regulation of coated formation vesicles inintracellular trafficking within the Golgi;functionally interchangeable with Arf1p 0.044980.14749&radic S000001563VMA5YKL080WverifiedSubunit C of the eight-subunit V1 peripheral membrane domain ofvacuolar H+-ATPase (V-ATPase), an electrogenicproton pump found throughout the endomembranesystem; required for the V1 domain to assembleonto the vacuolar membrane 0.044880.14729&radic S000005986VPS28YPL065WverifiedComponent of the ESCRT-I complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; involved in transport ofprecursors for soluble vacuolar hydrolases fromthe late endosome to the vacuole 0.044730.14685&radic S000004177SKG3YLR187WuncharacterizedProtein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to the cellperiphery, cytoplasm, bud, and bud neck;potential Cdc28p substrate; similar to Caf120pand Skg4p 0.044770.14685&radic&radic&radic&radic S000005023TPM1YNL079CverifiedMajor isoform of tropomyosin; binds to and stabilizes actincables and filaments, which direct polarizedcell growth and the distribution of severalorganelles; acetylated by the NatB complex andacetylated form binds actin most efficiently 0.044590.14637 S000004570CAC2YML102WverifiedComponent of the chromatin assembly complex (with Rlf2p andMsi1p) that assembles newly synthesizedhistones onto recently replicated DNA, requiredfor building functional kinetochores, conservedfrom yeast to humans 0.044420.14581 S000003481MGA1YGR249WverifiedProtein similar to heat shock transcription factor; multicopysuppressor of pseudohyphal growth defects ofammonium permease mutants 0.044380.14568&radic S000001593KTI12YKL110CverifiedProtein that plays a role, with Elongator complex, inmodification of wobble nucleosides in tRNA;involved in sensitivity to G1 arrest induced byzymocin; interacts with chromatin throughoutthe genome; also interacts with Cdc19p 0.044360.14567&radic&radic&radic&radic&radic S000002483RAD55YDR076WverifiedProtein that stimulates strand exchange by stabilizing thebinding of Rad51p to single-stranded DNA;involved in the recombinational repair ofdouble-strand breaks in DNA during vegetativegrowth and meiosis; forms heterodimer withRad57p 0.044130.14493&radic&radic&radic&radic&radic S000000360SLI15YBR156CverifiedSubunit of the Ipl1p-Sli15p-Bir1p complex that regulateskinetochore-microtubule attachments, activationof the spindle tension checkpoint, and mitoticspindle disassembly; regulates the activity andlocalization of the Ipl1p aurora kinase 0.044120.14489 S000003951TPO1YLL028WverifiedPolyamine transporter that recognizes spermine, putrescine, andspermidine; catalyzes uptake of polyamines atalkaline pH and excretion at acidic pH;phosphorylation enhances activity and sortingto the plasma membrane 0.044020.14458&radic&radic&radic&radic S000003026RAD6YGL058WverifiedUbiquitin-conjugating enzyme (E2), involved in postreplicationrepair (with Rad18p), sporulation, telomeresilencing, and ubiquitin-mediated N-end ruleprotein degradation (with Ubr1p) 0.043980.14434&radic&radic S000002736SKP1YDR328CverifiedEvolutionarily conserved kinetochore protein that is part ofmultiple protein complexes, including the SCFubiquitin ligase complex, the CBF3 complex thatbinds centromeric DNA, and the RAVE complexthat regulates assembly of the V-ATPase 0.043890.14416&radic&radic&radic S000005097GIM3YNL153CverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.043860.14403&radic&radic&radic S000000285SPT7YBR081CverifiedSubunit of the SAGA transcriptional regulatory complex,involved in proper assembly of the complex;also present as a C-terminally truncated formin the SLIK/SALSA transcriptional regulatorycomplex 0.043860.14403 S000005925LSP1YPL004CverifiedPrimary component of eisosomes, which are large immobile patchstructures at the cell cortex associated withendocytosis, along with Pil1p and Sur7p ; nullmutants show activation of Pkc1p/Ypk1p stressresistance pathways 0.043830.14391 S000001153UBA4YHR111WverifiedProtein that activates Urm1p before its conjugation to proteins(urmylation); one target is the thioredoxinperoxidase Ahp1p, suggesting a role ofurmylation in the oxidative stress response 0.043760.14378&radic&radic&radic S000000728WBP1YEL002CverifiedBeta subunit of the oligosaccharyl transferase (OST)glycoprotein complex; required for N-linkedglycosylation of proteins in the endoplasmicreticulum 0.043740.1437&radic&radic S000000316CYC8YBR112CverifiedGeneral transcriptional co-repressor, acts together with Tup1p;also acts as part of a transcriptionalco-activator complex that recruits the SWI/SNFand SAGA complexes to promoters 0.04370.14354 S000003246MSB2YGR014WverifiedMucin family member at the head of the Cdc42p- and MAPkinase-dependent filamentous growth signalingpathway; also functions as an osmosensor inparallel to the Sho1p-mediated pathway;potential Cdc28p substrate 0.043620.14332&radic&radic S000002781FRQ1YDR373WverifiedN-myristoylated calcium-binding protein that may have a role inintracellular signaling through its regulationof the phosphatidylinositol 4-kinase Pik1p;member of the recoverin/frequenin branch of theEF-hand superfamily 0.043410.14265&radic&radic S000002583NGG1YDR176WverifiedTranscriptional regulator involved in glucose repression ofGal4p-regulated genes; component oftranscriptional adaptor and histoneacetyltransferase complexes, the ADA complex,the SAGA complex, and the SLIK complex 0.043310.14228&radic&radic&radic S000002865TOM1YDR457WverifiedE3 ubiquitin ligase of the hect-domain class; has a role inmRNA export from the nucleus and may regulatetranscriptional coactivators 0.043240.14172 S000004312MMS22YLR320WverifiedProtein involved in resistance to ionizing radiation; acts withMms1p in a repair pathway that may be involvedin resolving replication intermediates orpreventing the damage caused by blockedreplication forks 0.043050.14139&radic&radic&radic S000004795SSO2YMR183CverifiedPlasma membrane t-SNARE involved in fusion of secretoryvesicles at the plasma membrane; syntaxinhomolog that is functionally redundant withSso1p 0.043070.14139&radic S000006076KIP2YPL155CverifiedKinesin-related motor protein involved in mitotic spindlepositioning, stabilizes microtubules bytargeting Bik1p to the plus end; Kip2p levelsare controlled during the cell cycle 0.043030.14124&radic S000005136CHS1YNL192WverifiedChitin synthase I, requires activation from zymogenic form inorder to catalyze the transfer ofN-acetylglucosamine (GlcNAc) to chitin;required for repairing the chitin septum duringcytokinesis; transcription activated by matingfactor 0.043010.14124&radic&radic&radic S000005261PFS2YNL317WverifiedIntegral subunit of the pre-mRNA cleavage and polyadenylationfactor (CPF) complex; plays an essential rolein mRNA 3'-end formation by bridging differentprocessing factors and thereby promoting theassembly of the processing complex 0.042930.14089&radic&radic&radic S000005082SRV2YNL138WverifiedCAP (cyclase-associated protein) subunit of adenylyl cyclasecomplex; N-terminus binds adenylyl cyclase andfacilitates activation by RAS; C-terminus bindsADP-actin monomers, facilitating regulation ofactin dynamics and cell morphogenesis &radic0.042850.14073&radic S000001198YSP1YHR155WuncharacterizedMitochondrial protein with a potential role in promotingmitochondrial fragmentation during programmedcell death in response to high levels ofalpha-factor mating pheromone or the drugamiodarone 0.042770.14041&radic&radic&radic&radic S000004898NGL2YMR285CverifiedProtein involved in 5.8S rRNA processing; Ccr4p-like RNaserequired for correct 3'-end formation of 5.8SrRNA at site E; similar to Ngl1p and Ngl3p 0.042720.14025&radic&radic S000005047MET4YNL103WverifiedLecine-zipper transcriptional activator, responsible for theregulation of the sulfur amino acid pathway,requires different combinations of theauxiliary factors Cbf1p, Met28p, Met31p andMet32p 0.042630.14005 S000001477GTT1YIR038CverifiedER associated glutathione S-transferase capable ofhomodimerization; expression induced during thediauxic shift and throughout stationary phase;functional overlap with Gtt2p, Grx1p, and Grx2p 0.042630.14&radic&radic S000002993PGD1YGL025CverifiedSubunit of the Mediator global transcriptional cofactorcomplex, which is part of the RNA polymerase IIholoenzyme and plays an essential role in basaland activated transcription; direct target ofthe Cyc8p-Tup1p transcriptional corepressor 0.042610.13996&radic&radic S000006099CBC2YPL178WverifiedSmall subunit of the heterodimeric cap binding complex thatalso contains Sto1p, component of thespliceosomal commitment complex; interacts withNpl3p, possibly to package mRNA for export fromthe nucleus; contains an RNA-binding motif 0.042610.13996&radic&radic&radic S000003594BIT61YJL058CverifiedSubunit of TORC2(Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p-Slm1p-Slm2p), a membrane-associated complex thatregulates cell cycle-dependent actincytoskeletal dynamics during polarized growthand cell wall integrity 0.04260.13979&radic S000004577ZDS2YML109WverifiedProtein that interacts with silencing proteins at the telomere,involved in transcriptional silencing; paralogof Zds1p 0.042480.13958&radic S000002413SOK1YDR006CverifiedProtein whose overexpression suppresses the growth defect ofmutants lacking protein kinase A activity;involved in cAMP-mediated signaling; localizedto the nucleus; similar to the mousetestis-specific protein PBS13 &radic0.042470.13949 S000001022ECM29YHL030WverifiedMajor component of the proteasome; tethers the proteasome coreparticle to the regulatory particle, andenhances the stability of the proteasome 0.042360.13916&radic&radic&radic&radic&radic S000001243RPN10YHR200WverifiedNon-ATPase base subunit of the 19S regulatory particle (RP) ofthe 26S proteasome; N-terminus plays a role inmaintaining the structural integrity of the RP;binds selectively to polyubiquitin chains;homolog of the mammalian S5a protein 0.042230.13875&radic&radic&radic S000006101TCO89YPL180WverifiedSubunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complexthat regulates growth in response to nutrientavailability; cooperates with Ssd1p in themaintenance of cellular integrity; deletionstrains are hypersensitive to rapamycin 0.042170.13857&radic&radic S000004236ERF2YLR246WverifiedSubunit of a palmitoyltransferase, composed of Erf2p and Shr5p,that adds a palmitoyl lipid moiety toheterolipidated substrates such as Ras1p andRas2p through a thioester linkage; mutantspartially mislocalize Ras2p to the vacuole 0.041980.138 S000006139SAR1YPL218WverifiedGTPase, GTP-binding protein of the ARF family, component ofCOPII coat of vesicles; required for transportvesicle formation during ER to Golgi proteintransport 0.041960.13775&radic&radic&radic S000000520BUD3YCL014WverifiedProtein involved in bud-site selection and required for axialbudding pattern; localizes with septins to budneck in mitosis and may constitute an axiallandmark for next round of budding 0.041950.13775&radic&radic&radic S000005633RGS2YOR107WverifiedNegative regulator of glucose-induced cAMP signaling; directlyactivates the GTPase activity of theheterotrimeric G protein alpha subunit Gpa2p &radic0.04190.13773&radic&radic&radic&radic&radic S000006403ARR1YPR199CverifiedTranscriptional activator of the bZIP family, required fortranscription of genes involved in resistanceto arsenic compounds 0.04190.13767&radic&radic S000002495SLU7YDR088CverifiedRNA splicing factor, required for ATP-independent portion of2nd catalytic step of spliceosomal RNAsplicing; interacts with Prp18p; contains zincknuckle domain 0.041820.1375&radic&radic&radic&radic S000003063VPS45YGL095CverifiedProtein of the Sec1p/Munc-18 family, essential for vacuolarprotein sorting; required for the function ofPep12p and the early endosome/late Golgi SNARETlg2p; essential for fusion of Golgi-derivedvesicles with the prevacuolar compartment 0.041650.13701 S000004421CRN1YLR429WverifiedCoronin, cortical actin cytoskeletal component that associateswith the Arp2p/Arp3p complex to regulate itsactivity 0.041670.13701 S000006095NIP100YPL174CverifiedLarge subunit of the dynactin complex, which is involved inpartitioning the mitotic spindle between motherand daughter cells; putative ortholog ofmammalian p150(glued) 0.041640.13694&radic S000004190YKE2YLR200WverifiedSubunit of the heterohexameric Gim/prefoldin protein complexinvolved in the folding of alpha-tubulin,beta-tubulin, and actin 0.041590.13676&radic&radic&radic&radic S000004837MRE11YMR224CverifiedSubunit of a complex with Rad50p and Xrs2p (RMX complex) thatfunctions in repair of DNA double-strand breaksand in telomere stability, exhibits nucleaseactivity that appears to be required for RMXfunction; widely conserved 0.041550.13655&radic&radic&radic&radic&radic S000005783CDC31YOR257WverifiedComponent of the spindle pole body (SPB) half-bridge, requiredfor SPB duplication in mitosis and meiosis II;homolog of mammalian centrin; interacts withKar1p 0.041510.13655&radic&radic&radic S000000920SHO1YER118CverifiedTransmembrane osmosensor, participates in activation of boththe Cdc42p- and MAP kinase-dependentfilamentous growth pathway and thehigh-osmolarity glycerol response pathway 0.041460.13638&radic S000005289VPS27YNR006WverifiedEndosomal protein that forms a complex with Hse1p; required forrecycling Golgi proteins, forming lumenalmembranes and sorting ubiquitinated proteinsdestined for degradation; has UbiquitinInteraction Motifs which bind ubiquitin (Ubi4p) 0.04140.13617 S000003484GCN5YGR252WverifiedHistone acetyltransferase, acetylates N-terminal lysines onhistones H2B and H3; catalytic subunit of theADA and SAGA histone acetyltransferasecomplexes; founding member of the Gcn5p-relatedN-acetyltransferase superfamily 0.041320.13591 S000003459DIE2YGR227WverifiedDolichyl-phosphoglucose-dependent glucosyltransferase of theER, functions in the dolichol pathway thatsynthesizes the dolichol-linked oligosaccharideprecursor for N-linked protein glycosylation,has a role in regulation of ITR1 and INO1 0.041270.13573&radic&radic S000003074MLC1YGL106WverifiedEssential light chain for myosin Myo2p; may stabilize Myo2p bybinding to the neck region; may interact withMyo1p, Iqg1p, and Myo2p to coordinate formationand contraction of the actomyosin ring withtargeted membrane deposition 0.041220.1356 S000006221DSS4YPR017CverifiedNucleotide release factor functioning in the post-Golgisecretory pathway, required for ER-to-Golgitransport, binds zinc, found both on membranesand in the cytosol; guanine nucleotidedissociation stimulator 0.041210.13559&radic S000003904PMT4YJR143CverifiedProtein O-mannosyltransferase, transfers mannose residues fromdolichyl phosphate-D-mannose to proteinserine/threonine residues; appears to formhomodimers in vivo and does not complex withother Pmt proteins; target for new antifungals 0.041210.13558 S000003051SCY1YGL083WverifiedPutative kinase, suppressor of GTPase mutant, similar to bovinerhodopsin kinase 0.041210.13554&radic&radic S000002334AIR2YDL175CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p; may regulatemethylation of Npl3p, which modulates Npl3pfunction in mRNA processing and export; hassimilarity to Air1p 0.041150.13537 S000002557NUM1YDR150WverifiedProtein required for nuclear migration, localizes to the mothercell cortex and the bud tip; may mediateinteractions of dynein and cytoplasmicmicrotubules with the cell cortex 0.041010.13497&radic&radic S000006345KAR3YPR141CverifiedMinus-end-directed microtubule motor that functions in mitosisand meiosis, localizes to the spindle pole bodyand localization is dependent on functionalCik1p, required for nuclear fusion duringmating; potential Cdc28p substrate 0.040690.13394&radic&radic S000004494RAD52YML032CverifiedProtein that stimulates strand exchange by facilitating Rad51pbinding to single-stranded DNA; annealscomplementary single-stranded DNA; involved inthe repair of double-strand breaks in DNAduring vegetative growth and meiosis 0.040570.13348&radic&radic&radic S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling 0.040250.1324&radic&radic&radic&radic&radic S000001912YFR016CVerifiedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene 0.040190.13232&radic&radic&radic&radic&radic S000004938FET4YMR319CverifiedLow-affinity Fe(II) transporter of the plasma membrane 0.040120.13204 S000002198NAT1YDL040CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.040120.13204&radic S000005171JJJ1YNL227CverifiedProtein that contains a 70 amino acid J-domain, may function asa co-chaperone to recruit Hsp70-like activityto specific sites; mutation causes defects influid-phase endocytosis 0.040130.13204&radic&radic&radic S000000950SPT15YER148WverifiedTATA-binding protein, general transcription factor thatinteracts with other factors to form thepreinitiation complex at promoters, essentialfor viability 0.040110.13204 S000003567MAD2YJL030WverifiedComponent of the spindle-assembly checkpoint complex, whichdelays the onset of anaphase in cells withdefects in mitotic spindle assembly; forms acomplex with Mad1p 0.040120.13204&radic S000005391SIL1YOL031CverifiedNucleotide exchange factor for the endoplasmic reticulum (ER)lumenal Hsp70 chaperone Kar2p, required forprotein translocation into the ER; homolog ofYarrowia lipolytica SLS1; GrpE-like protein 0.040050.13184&radic&radic&radic S000000104HIR1YBL008WverifiedNon-essential transcriptional corepressor involved in the cellcycle-regulated transcription of histone H2A,H2B, H3 and H4 genes; contributes to nucleosomeformation, heterochromatic gene silencing, andformation of functional kinetochores 0.040.13163&radic&radic&radic&radic&radic&radic S000000147PIN4YBL051CverifiedProtein involved in G2/M phase progression and response to DNAdamage, interacts with Rad53p; contains an RNArecognition motif, a nuclear localizationsignal, and several SQ/TQ cluster domains;hyperphosphorylated in response to DNA damage 0.039940.13142&radic&radic&radic S000001156BZZ1YHR114WverifiedSH3 domain protein implicated in the regulation of actinpolymerization, able to recruit actinpolymerization machinery through its SH3domains, colocalizes with cortical actinpatches and Las17p, interacts with type Imyosins 0.03980.1311&radic&radic S000001207DNA2YHR164CverifiedEssential tripartite DNA replication factor withsingle-stranded DNA-dependent ATPase,ATP-dependent nuclease, and helicaseactivities; required for Okazaki fragmentprocessing; involved in DNA repair pathways;potential Cdc28p substrate 0.039810.1311&radic S000002615UME6YDR207CverifiedKey transcriptional regulator of early meiotic genes, bindsURS1 upstream regulatory sequence, couplesmetabolic responses to nutritional cues withinitiation and progression of meiosis, formscomplex with Ime1p, and also with Sin3p-Rpd3p 0.039770.13092&radic&radic&radic S000005996GCR1YPL075WverifiedTranscriptional activator of genes involved in glycolysis;DNA-binding protein that interacts andfunctions with the transcriptional activatorGcr2p 0.039720.13082&radic&radic&radic&radic S000003539OST1YJL002CverifiedAlpha subunit of the oligosaccharyltransferase complex of theER lumen, which catalyzes asparagine-linkedglycosylation of newly synthesized proteins 0.039710.13079 S000006005BRO1YPL084WverifiedCytoplasmic class E vacuolar protein sorting (VPS) factor thatcoordinates deubiquitination in themultivesicular body (MVB) pathway by recruitingDoa4p to endosomes 0.03970.13077&radic S000001736SAP190YKR028WverifiedProtein that forms a complex with the Sit4p protein phosphataseand is required for its function; member of afamily of similar proteins including Sap4p,Sap155p, and Sap185p 0.039630.13049 S000001300NOT3YIL038CverifiedSubunit of the CCR4-NOT complex, which is a globaltranscriptional regulator with roles intranscription initiation and elongation and inmRNA degradation 0.039610.13046&radic S000000223GAL10YBR019CverifiedUDP-glucose-4-epimerase, catalyzes the interconversion ofUDP-galactose and UDP-D-glucose in galactosemetabolism; also catalyzes the conversion ofalpha-D-glucose or alpha-D-galactose to theirbeta-anomers 0.039590.13028 S000002578HSP42YDR171WverifiedSmall cytosolic stress-induced chaperone that formsbarrel-shaped oligomers and suppresses theaggregation of non-native proteins; oligomerdissociation is not required for function;involved in cytoskeleton reorganization afterheat shock 0.039550.13006&radic&radic&radic S000001502RAM2YKL019WverifiedAlpha subunit of both the farnesyltransferase and type Igeranylgeranyltransferase that catalyzeprenylation of proteins containing a CAAXconsensus motif; essential protein required formembrane localization of Ras proteins anda-factor 0.039380.12961&radic S000005554CIN5YOR028CverifiedBasic leucine zipper transcriptional factor of the yAP-1 familythat mediates pleiotropic drug resistance andsalt tolerance; localizes constitutively to thenucleus 0.039310.12933&radic&radic&radic S000002536SAC6YDR129CverifiedFimbrin, actin-bundling protein; cooperates with Scp1p(calponin/transgelin) in the organization andmaintenance of the actin cytoskeleton 0.039310.12933&radic&radic&radic S000004104AVL9YLR114CverifiedMutation is syntheticly lethal with apl2 vps1 double mutant 0.039290.12927&radic&radic&radic S000003146MPT5YGL178WverifiedMember of the Puf family of RNA-binding proteins; binds tomRNAs encoding chromatin modifiers and spindlepole body components; involved in longevity,maintenance of cell wall integrity, andsensitivity to and recovery from pheromonearrest 0.039270.12923&radic S000003635CHS6YJL099WverifiedMember of the Chs5p-Arf1p-binding proteins (ChAPs), a group of4 related, interacting proteins (Bch1p, Fmp50p,Bud7p, Chs6p) that mediate export of specificcargo proteins, including chitin synthaseChs3p, from the Golgi to plasma membrane 0.039150.1288 S000000129RIB1YBL033CverifiedGTP cyclohydrolase II; catalyzes the first step of theriboflavin biosynthesis pathway 0.039170.1288&radic&radic&radic&radic&radic S000004445RIF2YLR453CverifiedProtein that binds to the Rap1p C-terminus and actssynergistically with Rif1p to help controltelomere length and establish telomericsilencing; deletion results in telomereelongation 0.039130.12874&radic S000003432ELP2YGR200CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;target of Kluyveromyces lactis zymocin 0.039060.12849&radic&radic S000003345DAM1YGR113WverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; Ipl1p target forregulating kinetochore-MT attachments 0.039060.12849&radic&radic&radic&radic S000003131RAD54YGL163CverifiedDNA-dependent ATPase, stimulates strand exchange by modifyingthe topology of double-stranded DNA; involvedin the recombinational repair of double-strandbreaks in DNA during vegetative growth andmeiosis; member of the SWI/SNF family 0.038990.12821&radic S000004197HRD3YLR207WverifiedResident protein of the ER membrane that plays a central rolein ER-associated protein degradation (ERAD),forms HRD complex with Hrd1p and ERADdeterminants that engages in lumen to cytosolcommunication and coordination of ERAD events 0.038990.12821&radic&radic&radic S000001458MUC1YIR019CverifiedGPI-anchored cell surface glycoprotein required for diploidpseudohyphal formation and haploid invasivegrowth, transcriptionally regulated by the MAPKpathway (via Ste12p and Tec1p) and the cAMPpathway (via Flo8p) 0.038980.12821&radic&radic S000001371SEC24YIL109CverifiedComponent of the Sec23p-Sec24p heterodimeric complex of theCOPII vesicle coat; involved in ER to Golgitransport, cargo selection and autophagy;required for the binding of the Sec13 complexto ER membranes; homologous to Lst1p and Lss1p 0.038670.12722 S000002620TCP1YDR212WverifiedAlpha subunit of chaperonin-containing T-complex, whichmediates protein folding in the cytosol;involved in maintenance of actin cytoskeleton;homolog to Drosophila melanogaster and mousetailless complex polypeptide 0.038650.12715&radic&radic S000003101ITC1YGL133WverifiedComponent of the ATP-dependent Isw2p-Itc1p chromatin remodelingcomplex, required for repression of a-specificgenes, repression of early meiotic genes duringmitotic growth, and repression of INO1 0.038540.12677 S000001672HYM1YKL189WverifiedComponent of the RAM signaling network that is involved inregulation of Ace2p activity and cellularmorphogenesis, interacts with Kic1p and Sog2p,localizes to sites of polarized growth duringbudding and during the mating response 0.038540.12672&radic&radic&radic&radic S000002973COG7YGL005CverifiedComponent of the conserved oligomeric Golgi complex (Cog1pthrough Cog8p), a cytosolic tethering complexthat functions in protein trafficking tomediate fusion of transport vesicles to Golgicompartments 0.038520.12672&radic&radic&radic S000000897RAD51YER095WverifiedStrand exchange protein, forms a helical filament with DNA thatsearches for homology; involved in therecombinational repair of double-strand breaksin DNA during vegetative growth and meiosis;homolog of Dmc1p and bacterial RecA protein 0.038440.1264&radic S000004206CPR6YLR216CverifiedPeptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzesthe cis-trans isomerization of peptide bondsN-terminal to proline residues; binds to Hsp82pand contributes to chaperone activity 0.038360.12603&radic&radic S000004329VRP1YLR337CverifiedProline-rich actin-associated protein involved in cytoskeletalorganization and cytokinesis; related tomammalian Wiskott-Aldrich syndrome protein(WASP)-interacting protein (WIP) 0.038150.12543&radic&radic&radic S000003730CDC6YJL194WverifiedEssential ATP-binding protein required for DNA replication,component of the pre-replicative complex(pre-RC) which requires ORC to associate withchromatin and is in turn required for Mcm2-7pDNA association; homologous to S. pombe Cdc18p 0.038170.12543&radic&radic&radic&radic S000001047GPA1YHR005CverifiedGTP-binding alpha subunit of the heterotrimeric G protein thatcouples to pheromone receptors; negativelyregulates the mating pathway by sequesteringG(beta)gamma and by triggering an adaptiveresponse; activates Vps34p at the endosome &radic0.03810.12534 S000005953SVL3YPL032CverifiedProtein of unknown function, mutant phenotype suggests apotential role in vacuolar function; greenfluorescent protein (GFP)-fusion proteinlocalizes to the cell periphery, cytoplasm,bud, and bud neck 0.038090.1252&radic&radic&radic&radic&radic&radic S000000313CMD1YBR109CverifiedCalmodulin; Ca++ binding protein that regulates Ca++independent processes (mitosis, bud growth,actin organization, endocytosis, etc.) and Ca++dependent processes (stress-activatedpathways), targets include Nuf1p, Myo2p andcalcineurin 0.038070.1252&radic S000005830YOR304C-AUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck 0.038040.12509&radic&radic&radic&radic&radic S000001545MSN4YKL062WverifiedTranscriptional activator related to Msn2p; activated in stressconditions, which results in translocation fromthe cytoplasm to the nucleus; binds DNA atstress response elements of responsive genes,inducing gene expression 0.037920.12471&radic S000005620ARF3YOR094WverifiedGlucose-repressible ADP-ribosylation factor, GTPase of the Rassuperfamily involved in development of polarity 0.037920.12471&radic&radic&radic S000004815ERG2YMR202WverifiedC-8 sterol isomerase, catalyzes the isomerization of thedelta-8 double bond to the delta-7 position atan intermediate step in ergosterol biosynthesis 0.037880.12455&radic&radic S000001579CWP1YKL096WverifiedCell wall mannoprotein, linked to a beta-1,3- andbeta-1,6-glucan heteropolymer through aphosphodiester bond; involved in cell wallorganization 0.037880.12455&radic S000003579YJL043WUncharacterizedPutative protein of unknown function; YJL043W is a non-essential gene 0.037770.12416 S000001532CSE4YKL049CverifiedCentromere protein that resembles histones, required for properkinetochore function; homolog of human CENP-A 0.037730.12413&radic&radic&radic S000003616SCP160YJL080CverifiedEssential RNA-binding G protein effector of mating responsepathway, predominantly associated with nuclearenvelope and ER, interacts in mRNA-dependentmanner with translating ribosomes via multipleKH domains, similar to vertebrate vigilins 0.037560.12361 S000006385SEC23YPR181CverifiedGTPase-activating protein; component of the Sec23p-Sec24pheterodimeric complex of the COPII vesiclecoat, involved in ER to Golgi transport andautophagy; stimulates the GDP-bound form ofSar1p 0.037430.12319&radic&radic S000006326AXL1YPR122WverifiedHaploid specific endoprotease that performs one of twoN-terminal cleavages during maturation ofa-factor mating pheromone; required for axialbudding pattern of haploid cells 0.037360.1229&radic&radic S000004876SAP30YMR263WverifiedSubunit of a histone deacetylase complex, along with Rpd3p andSin3p, that is involved in silencing attelomeres, rDNA, and silent mating-type loci;involved in telomere maintenance 0.037410.1229&radic&radic S000000682CSM1YCR086WverifiedNucleolar protein that forms a complex with Lrs4p which bindsMam1p at kinetochores during meiosis I tomediate accurate chromosome segregation, may beinvolved in premeiotic DNA replication;possible role in telomere maintenance 0.03720.12247 S000005388YAP7YOL028CverifiedPutative basic leucine zipper (bZIP) transcription factor 0.03720.12247&radic&radic&radic&radic S000002764SPC110YDR356WverifiedInner plaque spindle pole body (SPB) component, ortholog ofhuman kendrin; involved in connecting nuclearmicrotubules to SPB; interacts withTub4p-complex and calmodulin; phosphorylated byMps1p in cell cycle-dependent manner 0.037180.12237&radic S000001868STE2YFL026WverifiedReceptor for alpha-factor pheromone; seven transmembrane-domainGPCR that interacts with both pheromone and aheterotrimeric G protein to initiate thesignaling response that leads to mating betweenhaploid a and alpha cells 0.037190.12237&radic S000005775APC5YOR249CverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 0.037090.12214&radic&radic S000002818STE14YDR410CverifiedFarnesyl cysteine-carboxyl methyltransferase, mediates thecarboxyl methylation step during C-terminalCAAX motif processing of a-factor and RASproteins in the endoplasmic reticulum,localizes to the ER membrane 0.0370.12186&radic S000004490TSA1YML028WverifiedUbiquitous housekeeping thioredoxin peroxidase, reducesreactive oxygen, nitrogen and sulfur speciesusing thioredoxin as hydrogen donor; mediatesredox regulation of the nuclear localization ofYap1p; deletion results in mutator phenotype 0.036870.12138&radic&radic&radic&radic S000001780SIS2YKR072CverifiedNegative regulatory subunit of the protein phosphatase 1 Ppz1p;involved in ion homeostasis and cell cycleprogression 0.036840.12138&radic&radic&radic S000001415RRD1YIL153WverifiedActivator of the phosphotyrosyl phosphatase activity of PP2A;regulates G1 phase progression, the G2/M phasetransition, microtubule dynamics, theosmoresponse, bud morphogenesis and DNA repair;subunit of the Tap42p-Sit4p-Rrd1p complex 0.036820.12135&radic S000001508PAN3YKL025CverifiedEssential subunit of the Pan2p-Pan3p poly(A)-ribonucleasecomplex, which acts to control poly(A) taillength and regulate the stoichiometry andactivity of postreplication repair complexes 0.036820.12118&radic&radic&radic&radic&radic S000003825CCT5YJR064WverifiedSubunit of the cytosolic chaperonin Cct ring complex, relatedto Tcp1p, required for the assembly of actinand tubulins in vivo 0.03680.12118 S000000885GET2YER083CverifiedSubunit of the GET complex; required for meiotic nucleardivision and for the retrieval of HDEL proteinsfrom the Golgi to the ER in an ERD2 dependentfashion; may be involved in cell wall function 0.036720.12098&radic&radic&radic&radic S000002988GET1YGL020CverifiedSubunit of the GET complex; required for the retrieval of HDELproteins from the Golgi to the ER in an ERD2dependent fashion and for normal mitochondrialmorphology and inheritance 0.03670.12093 S000000442YBR238CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and mitochondrion; YBR238C is not an essential gene; transcriptionally up-regulated by TOR and deletion increases life span 0.03670.12092&radic S000005266KRE1YNL322CverifiedCell wall glycoprotein involved in beta-glucan assembly; servesas a K1 killer toxin membrane receptor 0.036680.12088&radic S000002759SBE2YDR351WverifiedProtein involved in the transport of cell wall components fromthe Golgi to the cell surface; required for budgrowth 0.036640.12079&radic&radic&radic S000001915FAB1YFR019Wverified1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membranekinase that generates phosphatidylinositol(3,5)P2, which is involved in vacuolar sortingand homeostasis 0.036590.12058 S000005364SIN3YOL004WverifiedComponent of the Sin3p-Rpd3p histone deacetylase complex,involved in transcriptional repression andactivation of diverse processes, includingmating-type switching and meiosis; involved inthe maintenance of chromosomal integrity 0.036510.12034&radic&radic&radic&radic S000000556LRE1YCL051WverifiedProtein involved in control of cell wall structure and stressresponse; inhibits Cbk1p protein kinaseactivity; overproduction confers resistance tocell-wall degrading enzymes 0.036380.11997&radic&radic S000005241MON2YNL297CverifiedPeripheral membrane protein with a role in endocytosis andvacuole integrity, interacts with Arl1p andlocalizes to the endosome; member of the Sec7pfamily of proteins 0.036320.11974 S000000438ARC40YBR234CverifiedEssential subunit of the ARP2/3 complex, which is required forthe motility and integrity of cortical actinpatches 0.03630.11971&radic&radic&radic&radic S000005670ELG1YOR144CverifiedProtein required for S phase progression and telomerehomeostasis, forms an alternative replicationfactor C complex important for DNA replicationand genome integrity; involved in homologousrecombination-mediated DNA repair 0.036230.11947&radic&radic&radic S000005556DFG16YOR030WverifiedProbable multiple transmembrane protein, involved in diploidinvasive and pseudohyphal growth upon nitrogenstarvation; required for accumulation ofprocessed Rim101p 0.036210.11937&radic&radic&radic S000001204YAP1801YHR161CverifiedProtein involved in clathrin cage assembly; binds Pan1p andclathrin; homologous to Yap1802p, member of theAP180 protein family 0.036140.11923&radic&radic&radic&radic S000004641CCS1YMR038CverifiedCopper chaperone for superoxide dismutase Sod1p, involved inoxidative stress protection; Met-X-Cys-X2-Cysmotif within the N-terminal portion is involvedin insertion of copper into Sod1p underconditions of copper deprivation 0.036140.11923&radic&radic&radic&radic S000003557BBC1YJL020CverifiedProtein possibly involved in assembly of actin patches;interacts with an actin assembly factor Las17pand with the SH3 domains of Type I myosinsMyo3p and Myo5p; localized predominantly tocortical actin patches 0.036160.11923 S000000002VPS8YAL002WverifiedMembrane-associated hydrophilic protein that interacts with thesmall GTPase, Vps21p, to facilitate solublevacuolar protein localization; required forlocalization and trafficking of the CPY sortingreceptor; contains a RING finger motif 0.036140.11923&radic&radic&radic S000001596RAD27YKL113Cverified5' to 3' exonuclease, 5' flap endonuclease, required forOkazaki fragment processing and maturation aswell as for long-patch base-excision repair;member of the S. pombe RAD2/FEN1 family 0.03610.11907&radic&radic&radic&radic S000004836UBP8YMR223WverifiedUbiquitin-specific protease that is a component of the SAGA(Spt-Ada-Gcn5-Acetyltransferase) acetylationcomplex; required for SAGA-mediateddeubiquitination of histone H2B 0.035960.11859&radic&radic&radic S000003494BUD32YGR262CverifiedProtein kinase proposed to be involved in bud-site selection,telomere uncapping and elongation, andtranscription; component of the EKC/KEOPSprotein complex with Kae1p, Cgi121p, Pcc1p, andGon7p 0.035970.11859&radic&radic&radic S000005854SNC2YOR327CverifiedVesicle membrane receptor protein (v-SNARE) involved in thefusion between Golgi-derived secretory vesicleswith the plasma membrane; member of thesynaptobrevin/VAMP family of R-type v-SNAREproteins 0.035870.11834&radic&radic&radic S000004802SGS1YMR190CverifiedNucleolar DNA helicase of the RecQ family involved inmaintenance of genome integrity, regulateschromosome synapsis and meiotic crossing over;has similarity to human BLM and WRN helicasesimplicated in Bloom and Werner syndromes 0.035810.11813&radic&radic&radic&radic S000000189ROX3YBL093CverifiedRNA polymerase II holoenzyme component 0.035730.11788&radic&radic&radic S000000521DCC1YCL016CverifiedSubunit of a complex with Ctf8p and Ctf18p that shares somecomponents with Replication Factor C, requiredfor sister chromatid cohesion and telomerelength maintenance 0.035710.11785&radic&radic S000006155TFP3YPL234CverifiedVacuolar ATPase V0 domain subunit c', involved in protontransport activity; hydrophobic integralmembrane protein (proteolipid) containing fourtransmembrane segments; N and C termini are inthe vacuolar lumen 0.035670.11771&radic&radic&radic&radic S000000533RNQ1YCL028Wverified[PIN(+)] prion, an infectious protein conformation that isgenerally an ordered protein aggregate 0.035590.11743&radic&radic&radic&radic S000003670LCB3YJL134WverifiedLong-chain base-1-phosphate phosphatase, regulates ceramide andlong-chain base phosphates levels, involved inincorporation of exogenous long chain bases insphingolipids &radic0.03550.11711&radic&radic&radic S000004757SWP1YMR149WverifiedDelta subunit of the oligosaccharyl transferase glycoproteincomplex, which is required for N-linkedglycosylation of proteins in the endoplasmicreticulum 0.03550.11702&radic&radic&radic S000004029RIC1YLR039CverifiedProtein involved in retrograde transport to the cis-Golginetwork; forms heterodimer with Rgp1p that actsas a GTP exchange factor for Ypt6p; involved intranscription of rRNA and ribosomal proteingenes 0.035460.11693 S000005176CSL4YNL232WverifiedSubunit of the exosome, which is an essential complex presentin both nucleus and cytoplasm that mediates RNAprocessing and degradation 0.035370.11663&radic&radic&radic S000002789YRA1YDR381WverifiedNuclear protein that binds to RNA and to Mex67p, required forexport of poly(A)+ mRNA from the nucleus;member of the REF (RNA and export factorbinding proteins) family; another familymember, Yra2p, can substitute for Yra1pfunction 0.035270.11627&radic&radic&radic&radic S000002232BRE1YDL074CverifiedE3 ubiquitin ligase for Rad6p, required for the ubiquitinationof histone H2B, recruitment of Rad6p topromoter chromatin and subsequent methylationof histone H3 (on L4 and L79), contains RINGfinger domain 0.035260.1162 S000005902GDH1YOR375CverifiedNADP(+)-dependent glutamate dehydrogenase, synthesizesglutamate from ammonia and alpha-ketoglutarate;rate of alpha-ketoglutarate utilization differsfrom Gdh3p; expression regulated by nitrogenand carbon sources 0.035130.11573&radic&radic&radic&radic S000003733UBP12YJL197WverifiedUbiquitin-specific protease present in the nucleus andcytoplasm that cleaves ubiquitin fromubiquitinated proteins 0.035130.11573&radic&radic S000005475PAP2YOL115WverifiedCatalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), anuclear poly (A) polymerase complex involved inRNA quality control; catalyzes polyadenylationof unmodified tRNAs, and snoRNA and rRNAprecursors; disputed role as a DNA polymerase 0.035060.11547 S000002411RAD57YDR004WverifiedProtein that stimulates strand exchange by stabilizing thebinding of Rad51p to single-stranded DNA;involved in the recombinational repair ofdouble-strand breaks in DNA during vegetativegrowth and meiosis; forms heterodimer withRad55p 0.035030.11542&radic S000005611OST3YOR085WverifiedGamma subunit of the oligosaccharyltransferase complex of theER lumen, which catalyzes asparagine-linkedglycosylation of newly synthesized proteins;Ost3p is important for N-glycosylation of asubset of proteins 0.0350.11537&radic&radic&radic S000005000POR1YNL055CverifiedMitochondrial porin (voltage-dependent anion channel), outermembrane protein required for the maintenanceof mitochondrial osmotic stability andmitochondrial membrane permeability 0.034980.1152&radic S000003466YHB1YGR234WverifiedNitric oxide oxidoreductase, flavohemoglobin involved in nitricoxide detoxification; plays a role in theoxidative and nitrosative stress responses 0.034970.1152&radic&radic&radic&radic S000006026YPL105CUncharacterizedHypothetical protein 0.034940.11519&radic&radic&radic&radic S000000757SPF1YEL031WverifiedP-type ATPase, ion transporter of the ER membrane involved inER function and Ca2+ homeostasis; required forregulating Hmg2p degradation; conferssensitivity to a killer toxin (SMKT) producedby Pichia farinosa KK1 0.034940.11511&radic S000000993RPL14BYHL001WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl14Ap and has similarity to ratL14 ribosomal protein 0.034910.11508&radic S000001069RPN1YHR027CverifiedNon-ATPase base subunit of the 19S regulatory particle of the26S proteasome; may participate in therecognition of several ligands of theproteasome; contains a leucine-rich repeat(LRR) domain, a site for protein?proteininteractions 0.034830.11476&radic S000005564HIR2YOR038CverifiedNon-essential transcriptional corepressor involved in the cellcycle-regulated transcription of histone H2A,H2B, H3, and H4 genes; recruits Swi-Snfcomplexes to histone gene promoters; promotesheterochromatic gene silencing with Asf1p 0.03480.11465&radic&radic&radic S000000657YCR061WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.034780.11461&radic S000004537TCB3YML072CverifiedLipid-binding protein, localized to the bud via specific mRNAtransport; non-tagged protein localizes tomitochondria and GFP-fusion protein localizesto the cell periphery; C-termini of Tcb1p,Tcb2p and Tcb3p interact 0.034750.11452&radic S000005029MKT1YNL085WverifiedProtein that forms a complex with Pbp1p that may mediateposttranscriptional regulation of HOendonuclease; involved in propagation of M2dsRNA satellite of L-A virus 0.03470.11423&radic S000000922SCS2YER120WverifiedIntegral ER membrane protein that regulates phospholipidmetabolism via an interaction with the FFATmotif of Opi1p, also involved in telomericsilencing, disruption causes inositolauxotrophy above 34 degrees C, VAP homolog 0.034680.11423 S000002314CLB3YDL155WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the G2/M transition; may beinvolved in DNA replication and spindleassembly; accumulates during S phase and G2,then targeted for ubiquitin-mediateddegradation 0.034610.11399&radic S000003098CEG1YGL130WverifiedAlpha (guanylyltransferase) subunit of the mRNA capping enzyme,a heterodimer (the other subunit is CET1, anRNA 5'-triphophatase) involved in adding the 5'cap to mRNA; the mammalian enzyme is a singlebifunctional polypeptide 0.034580.11389&radic S000003628HPR5YJL092WverifiedDNA helicase and DNA-dependent ATPase involved in DNA repair,required for proper timing of commitment tomeiotic recombination and the transition fromMeiosis I to Meiosis II; potential Cdc28psubstrate 0.034550.11376 S000004929ELP6YMR312WverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;required for Elongator structural integrity 0.034540.11376 S000006217YPR013CUncharacterizedPutative zinc finger protein; YPR013C is not an essential gene 0.034410.11321 S000004742GID8YMR135CverifiedProtein of unknown function, involved in proteasome-dependentcatabolite inactivation offructose-1,6-bisphosphatase; contains LisH andCTLH domains, like Vid30p; dosage-dependentregulator of START 0.034410.11321&radic S000004017AAT2YLR027CverifiedCytosolic aspartate aminotransferase, involved in nitrogenmetabolism; localizes to peroxisomes inoleate-grown cells 0.03430.11292&radic&radic&radic S000005222CAF120YNL278WverifiedPart of the evolutionarily-conserved CCR4-NOT transcriptionalregulatory complex involved in controlling mRNAinitiation, elongation, and degradation 0.03430.11292&radic&radic&radic&radic S000000787CIN8YEL061CverifiedKinesin motor protein involved in mitotic spindle assembly andchromosome segregation 0.034250.11274&radic S000005601UFE1YOR075Wverifiedt-SNARE required for ER membrane fusion and vesicular traffic,integral membrane protein that constitutes withSec20p and Use1p the trimeric acceptor forR/v-SNAREs on Golgi-derived vesicles at the ER;part of Dsl1p complex 0.034270.11274&radic&radic S000004253RED1YLR263WverifiedProtein component of the axial elements of the synaptonemalcomplex, involved in chromosome segregationduring the first meiotic division; interactswith Hop1p; required for wild-type levels ofMek1p kinase activity 0.03420.11254&radic&radic S000000227CHS3YBR023CverifiedChitin synthase III, catalyzes the transfer ofN-acetylglucosamine (GlcNAc) to chitin;required for synthesis of the majority of cellwall chitin, the chitin ring during budemergence, and spore wall chitosan 0.034180.11249 S000005293CSE2YNR010WverifiedComponent of the Med9/10 module, which is a subcomplex withinthe RNA polymerase II Mediator complex;required for regulation of RNA polymerase IIactivity 0.034170.11247 S000003674TIF2YJL138CverifiedTranslation initiation factor eIF4A, identical to Tif1p;DEA(D/H)-box RNA helicase that couples ATPaseactivity to RNA binding and unwinding; forms adumbbell structure of two compact domainsconnected by a linker; interacts with eIF4G 0.03410.11222&radic&radic&radic S000003135PMR1YGL167CverifiedHigh affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ andMn2+ transport into Golgi; involved in Ca2+dependent protein sorting and processing;mutations in human homolog ATP2C1 causeacantholytic skin condition Hailey-Haileydisease 0.034020.11193 S000000046GEM1YAL048CverifiedEvolutionarily-conserved tail-anchored outer mitochondrialmembrane GTPase which regulates mitochondrialmorphology; cells lacking Gem1p containcollapsed, globular, or grape-likemitochondria; not required forpheromone-induced cell death 0.034050.11193&radic&radic S000005552BUB3YOR026WverifiedKinetochore checkpoint WD40 repeat protein that localizes tokinetochores during prophase and metaphase,delays anaphase in the presence of unattachedkinetochores; forms complexes with Mad1p-Bub1pand with Cdc20p, binds Mad2p and Mad3p 0.033950.11173&radic&radic S000000824SRB4YER022WverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation 0.033930.11162&radic S000005735NPT1YOR209CverifiedNicotinate phosphoribosyltransferase, acts in the salvagepathway of NAD+ biosynthesis; required forsilencing at rDNA and telomeres and has a rolein silencing at mating-type loci; localized tothe nucleus 0.033890.11149&radic&radic&radic S000002469LCB2YDR062WverifiedComponent of serine palmitoyltransferase, responsible alongwith Lcb1p for the first committed step insphingolipid synthesis, which is thecondensation of serine with palmitoyl-CoA toform 3-ketosphinganine 0.033830.1113&radic&radic&radic S000004976HHT2YNL031CverifiedOne of two identical histone H3 proteins (see also HHT1); corehistone required for chromatin assembly,involved in heterochromatin-mediated telomericand HM silencing; regulated by acetylation,methylation, and mitotic phosphorylation 0.033810.11121 S000005596GYP1YOR070CverifiedCis-golgi GTPase-activating protein (GAP) for the Rab familymembers Ypt1p (in vivo) and for Ypt1p, Sec4p,Ypt7p, and Ypt51p (in vitro); involved invesicle docking and fusion 0.033750.111&radic&radic S000000018ATS1YAL020CverifiedProtein required, with Elongator complex, Kti11p, and Kti12p,for modification of wobble nucleosides in tRNA;has a potential role in regulatory interactionsbetween microtubules and the cell cycle 0.03370.11089&radic&radic S000003213RTF1YGL244WverifiedSubunit of the RNA polymerase II-associated Paf1 complex;directly or indirectly regulates DNA-bindingproperties of Spt15p and relative activities ofdifferent TATA elements; involved in telomeremaintenance 0.033660.11079&radic S000005959MET31YPL038WverifiedZinc-finger DNA-binding protein, involved in regulatingexpression of the methionine biosyntheticgenes, similar to Met32p 0.033660.11079&radic&radic&radic&radic S000003651ASF1YJL115WverifiedNucleosome assembly factor, involved in chromatin assembly anddisassembly, anti-silencing protein that causesderepression of silent loci when overexpressed 0.033620.1106 S000004012SDO1YLR022CuncharacterizedEssential protein involved in RNA metabolism, one of two yeasthomologs (with Yhr087wp) of the human proteinSBDS responsible for autosomal recessiveShwachman-Bodian-Diamond Syndrome, alsoconserved in Archaea 0.033610.1106&radic&radic&radic&radic S000000784PCM1YEL058WverifiedEssential N-acetylglucosamine-phosphate mutase, ahexosephosphate mutase involved in thebiosynthesis of chitin 0.033610.11057&radic&radic&radic S000001171ARP1YHR129CverifiedActin-related protein of the dynactin complex; required forspindle orientation and nuclear migration;putative ortholog of mammalian centractin 0.033560.11039&radic&radic&radic S000002537FIN1YDR130CverifiedSpindle pole body-related intermediate filament protein, formscell cycle-specific filaments between spindlepole bodies in mother and daughter cells, ableto self-assemble, expression induced duringS/G2, localization cell-cycle dependent 0.033550.11037&radic&radic S000001143BIG1YHR101CverifiedIntegral membrane protein of the endoplasmic reticulum,required for normal content of cell wallbeta-1,6-glucan 0.03350.1102&radic&radic S000005606DIA2YOR080WverifiedOrigin-binding F-box protein that forms an SCF ubiquitin ligasecomplex with Skp1p and Cdc