Yfunc lets you browse current and predicted gene functions in yeast

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Prediction of GO:0008080 "N-acetyltransferase activity"

GO branch: MF
Number of currently annotated genes: 37

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest TAP:74Lum:Sodium ChlorideLum:ProcainePS51186Huh:cytoplasmTAP:136TAP:19IPR001878Lum:NevirapineHarbison:YBR267W_YPD S000003484GCN5YGR252WverifiedHistone acetyltransferase, acetylates N-terminal lysines onhistones H2B and H3; catalytic subunit of theADA and SAGA histone acetyltransferasecomplexes; founding member of the Gcn5p-relatedN-acetyltransferase superfamily &radic0.687070.98165&radic&radic S000006007ELP3YPL086CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;exhibits histone acetyltransferase activitythat is directed to histones H3 and H4;disruption confers resistance to K. lactiszymotoxin &radic0.709850.98165&radic&radic&radic&radic&radic S000001055ARD1YHR013CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing &radic0.700770.98165&radic&radic&radic&radic S000006255MAK3YPR051WverifiedCatalytic subunit of N-terminal acetyltransferase of the NatCtype; required for replication of dsRNA virus &radic0.636580.95823&radic&radic S000006335NAT3YPR131CverifiedCatalytic subunit of the NatB N-terminal acetyltransferase,which catalyzes acetylation of theamino-terminal methionine residues of allproteins beginning with Met-Asp or Met-Glu andof some proteins beginning with Met-Asn orMet-Met &radic0.655860.95823&radic&radic&radic&radic S000005779NAT5YOR253WverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing &radic0.647850.95823&radic&radic&radic&radic S000005770ESA1YOR244WverifiedHistone acetyltransferase catalytic subunit of the nativemultisubunit complex (NuA4) that acetylatesfour conserved internal lysines of histone H4N-terminal tail; required for cell cycleprogression &radic0.550260.95823&radic&radic&radic&radic S000001481YIR042CUncharacterizedPutative protein of unknown function; YIR042C is a non-essential gene 0.506590.94881&radic&radic S000002478PAA1YDR071CverifiedPolyamine acetyltransferase; acetylates polyamines (e.g.putrescine, spermidine, spermine) and alsoaralkylamines (e.g. tryptamine,phenylethylamine); may be involved intranscription and/or DNA replication &radic0.491820.94505&radic&radic S000005922HAT1YPL001WverifiedCatalytic subunit of the Hat1p-Hat2p histone acetyltransferasecomplex that uses the cofactor acetyl coenzymeA, to acetylate free nuclear and cytoplasmichistone H4; involved in telomeric silencing andDNA double-strand break repair &radic0.45190.93469&radic&radic S000003663SPT10YJL127CverifiedPutative histone acetylase, sequence-specific activator ofhistone genes, binds specifically and highlycooperatively to pairs of UAS elements in corehistone promoters, functions at or near theTATA box &radic0.409390.93469&radic&radic S000004673NAT4YMR069WverifiedN alpha-acetyl-transferase, involved in acetylation of theN-terminal residues of histones H4 and H2A &radic0.391440.93376&radic&radic&radic S000000792HPA3YEL066WverifiedD-Amino acid N-acetyltransferase, catalyzes N-acetylation ofD-amino acids through ordered bi-bi mechanismin which acetyl-CoA is first substrate boundand CoA is last product liberated; similar toHpa2p, acetylates histones weakly in vitro &radic0.383360.93376&radic&radic&radic&radic S000001877GNA1YFL017CverifiedEvolutionarily conserved glucosamine-6-phosphateacetyltransferase required for multiple cellcycle events including passage through START,DNA synthesis, and mitosis; involved inUDP-N-acetylglucosamine synthesis, formsGlcNAc6P from AcCoA &radic0.368190.93097&radic&radic&radic&radic&radic&radic S000001855ACT1YFL039CverifiedActin, structural protein involved in cell polarization,endocytosis, and other cytoskeletal functions 0.365890.92899&radic&radic&radic S000006397HPA2YPR193CverifiedTetrameric histone acetyltransferase with similarity to Gcn5p,Hat1p, Elp3p, and Hpa3p; acetylates histones H3and H4 in vitro and exhibits autoacetylationactivity &radic0.354010.92464&radic&radic&radic S000004734SAS2YMR127CverifiedHistone acetyltransferase (HAT) catalytic subunit of the SAScomplex (Sas2p-Sas4p-Sas5p), which acetylatesfree histones and nucleosomes and regulatestranscriptional silencing; member of theMYSTacetyltransferase family &radic0.326530.90486&radic S000005051YAF9YNL107WverifiedSubunit of both the NuA4 histone H4 acetyltransferase complexand the SWR1 complex, may function toantagonize silencing near telomeres; interactsdirectly with Swc4p, has homology to humanleukemogenic protein AF9, contains a YEATSdomain 0.306890.89781&radic&radic S000006050TAF14YPL129WverifiedSubunit (30 kDa) of TFIID, TFIIF, and SWI/SNF complexes,involved in RNA polymerase II transcriptioninitiation and in chromatin modification,contains a YEATS domain 0.300140.89166 S000000148SAS3YBL052CverifiedHistone acetyltransferase catalytic subunit of NuA3 complexthat acetylates histone H3, involved intranscriptional silencing; homolog of themammalian MOZ proto-oncogene; sas3 gcn5 doublemutation confers lethality &radic0.261220.87768&radic S000000779MAK10YEL053CverifiedNon-catalytic subunit of N-terminal acetyltransferase of theNatC type, required for replication of dsRNAvirus; expression is glucose-repressible &radic0.204780.8316&radic&radic S000000744EAF5YEL018WuncharacterizedEsa1p-associated factor, subunit of the NuA4 acetyltransferasecomplex 0.170780.79505&radic&radic&radic&radic S000001141TRA1YHR099WverifiedSubunit of SAGA and NuA4 histone acetyltransferase complexes;interacts with acidic activators (e.g., Gal4p)which leads to transcription activation;similar to human TRRAP, which is a cofactor forc-Myc mediated oncogenic transformation &radic0.165440.78829&radic S000004975HHF2YNL030WverifiedOne of two identical histone H4 proteins (see also HHF1); corehistone required for chromatin assembly andchromosome function; contributes to telomericsilencing; N-terminal domain involved inmaintaining genomic integrity 0.158790.77928&radic S000002767VID21YDR359CverifiedComponent of the NuA4 histone acetyltransferase complex 0.155470.77625&radic&radic&radic S000003617ARP4YJL081CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes &radic0.147260.76365&radic S000000614MAK31YCR020C-AverifiedNon-catalytic subunit of N-terminal acetyltransferase of theNatC type; required for replication of dsRNAvirus; member of the Sm protein family &radic0.14190.75535&radic&radic S000004466YAP1YML007WverifiedBasic leucine zipper (bZIP) transcription factor required foroxidative stress tolerance; mediatespleiotropic drug and metal resistance;localized to the nucleus in response to thepresence of oxidants 0.133720.7427&radic&radic&radic&radic&radic S000001870EPL1YFL024CverifiedComponent of NuA4, which is an essential histone H4/H2Aacetyltransferase complex; homologous toDrosophila Enhancer of Polycomb &radic0.13090.73906&radic&radic&radic&radic S000002574TAF10YDR167WverifiedSubunit (145 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification 0.114260.70774&radic&radic S000006022ELP4YPL101WverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;required for Elongator structural integrity 0.113230.70577 S000003432ELP2YGR200CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;target of Kluyveromyces lactis zymocin 0.112730.70443&radic&radic S000006227EAF3YPR023CverifiedEsa1p-associated factor, nonessential component of the NuA4acetyltransferase complex, homologous toDrosophila dosage compensation protein MSL3 &radic0.097210.67828&radic S000000966CHD1YER164WverifiedNucleosome remodeling factor that functions in regulation oftranscription elongation; contains a chromodomain, a helicase domain and a DNA-bindingdomain; component of both the SAGA and SILKcomplexes 0.091840.66268 S000005446ADH1YOL086CverifiedAlcohol dehydrogenase, fermentative isozyme active as homo- orheterotetramers; required for the reduction ofacetaldehyde to ethanol, the last step in theglycolytic pathway 0.087360.64893&radic S000003827TOR1YJR066WverifiedPIK-related protein kinase and rapamycin target; subunit ofTORC1, a complex that controls growth inresponse to nutrients by regulatingtranslation, transcription, ribosomebiogenesis, nutrient transport and autophagy;involved in meiosis 0.073680.60657&radic&radic S000001686TOR2YKL203CverifiedPIK-related protein kinase and rapamycin target; subunit ofTORC1, a complex that regulates growth inresponse to nutrients and TORC2, a complex thatregulates cell-cycle dependent polarization ofthe actin cytoskeleton; involved in meiosis 0.073080.60388 S000001230IKI1YHR187WverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;iki1 mutations confer resistance to the K.lactis toxin zymocin 0.069250.59102&radic S000004840TAF7YMR227CverifiedTFIID subunit (67 kDa), involved in RNA polymerase IItranscription initiation 0.069150.59017&radic&radic&radic&radic S000000871ARG5,6YER069WverifiedProtein that is processed in the mitochondrion to yieldacetylglutamate kinase andN-acetyl-gamma-glutamyl-phosphate reductase,which catalyze the 2nd and 3rd steps inarginine biosynthesis; enzymes form a complexwith Arg2p 0.062560.56702&radic S000004722ASC1YMR116CverifiedWD repeat protein (G-beta like protein) involved in translationregulation; required for repression of Gcn4pactivity in the absence of amino-acidstarvation; core component of the ribosome;ortholog of mammalian RACK1 0.057190.5437 S000003486ENO1YGR254WverifiedEnolase I, a phosphopyruvate hydratase that catalyzes theconversion of 2-phosphoglycerate tophosphoenolpyruvate during glycolysis and thereverse reaction during gluconeogenesis;expression is repressed in response to glucose 0.055150.53532&radic S000002552TAF12YDR145WverifiedSubunit (61/68 kDa) of TFIID and SAGA complexes, involved inRNA polymerase II transcription initiation andin chromatin modification, similar to histoneH2A 0.053660.52762&radic&radic S000000288MIS1YBR084WverifiedMitochondrial C1-tetrahydrofolate synthase, involved ininterconversion between different oxidationstates of tetrahydrofolate (THF); providesactivities of formyl-THF synthetase,methenyl-THF cyclohydrolase, and methylene-THFdehydrogenase 0.050160.5105 S000000340MEC1YBR136WverifiedGenome integrity checkpoint protein and PI kinase superfamilymember; signal transducer required for cellcycle arrest and transcriptional responsesprompted by damaged or unreplicated DNA;monitors and participates in meioticrecombination 0.0490.50298 S000006147NEW1YPL226WverifiedATP binding cassette family member; Asn/Gln-rich rich regionsupports [NU+] prion formation, susceptibilityto [PSI+] prion induction and aggregation of afragment of the human Machado-Joseph Diseaseprotein 0.047490.49643&radic S000003322UTP22YGR090WuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.045610.48918&radic&radic S000000402TAF5YBR198CverifiedSubunit (90 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification 0.042660.47389&radic&radic S000001065MYO1YHR023WverifiedType II myosin heavy chain, required for wild-type cytokinesisand cell separation; localizes to theactomyosin ring; binds to myosin light chainsMlc1p and Mlc2p through its IQ1 and IQ2 motifsrespectively 0.041170.4701 S000000316CYC8YBR112CverifiedGeneral transcriptional co-repressor, acts together with Tup1p;also acts as part of a transcriptionalco-activator complex that recruits the SWI/SNFand SAGA complexes to promoters 0.040510.46645 S000001132YNG2YHR090CverifiedSubunit of the NuA4 histone acetyltransferase complex thatacetylates histone H4 and H2A; has similarityto the human tumor suppressor ING1 0.03840.45822 S000002583NGG1YDR176WverifiedTranscriptional regulator involved in glucose repression ofGal4p-regulated genes; component oftranscriptional adaptor and histoneacetyltransferase complexes, the ADA complex,the SAGA complex, and the SLIK complex 0.036250.44894&radic&radic&radic&radic S000003712SWI3YJL176CverifiedSubunit of the SWI/SNF chromatin remodeling complex, whichregulates transcription by remodelingchromosomes; required for transcription of manygenes, including ADH1, ADH2, GAL1, HO, INO1 andSUC2 0.034890.44267&radic&radic S000000184TEL1YBL088CverifiedProtein kinase primarily involved in telomere lengthregulation; contributes to cell cyclecheckpoint control in response to DNA damage;functionally redundant with Mec1p; homolog ofhuman ataxia telangiectasia (ATM) gene 0.034170.43807&radic S000002856ADA2YDR448WverifiedTranscription coactivator, component of the ADA and SAGAtranscriptional adaptor/HAT (histoneacetyltransferase) complexes 0.03430.43807&radic S000000285SPT7YBR081CverifiedSubunit of the SAGA transcriptional regulatory complex,involved in proper assembly of the complex;also present as a C-terminally truncated formin the SLIK/SALSA transcriptional regulatorycomplex 0.034150.43807&radic S000003848YJR088CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum 0.033450.43352 S000006175HFI1YPL254WverifiedAdaptor protein required for structural integrity of the SAGAcomplex, a histoneacetyltransferase-coactivator complex that isinvolved in global regulation of geneexpression through acetylation andtranscription functions 0.032890.43249&radic&radic S000004836UBP8YMR223WverifiedUbiquitin-specific protease that is a component of the SAGA(Spt-Ada-Gcn5-Acetyltransferase) acetylationcomplex; required for SAGA-mediateddeubiquitination of histone H2B 0.032160.42879&radic&radic&radic S000000329PTC4YBR125CverifiedCytoplasmic type 2C protein phosphatase; identified as ahigh-copy number suppressor of the syntheticlethality of a cnb1 mpk1 double deletion;overexpression decreases high-osmolarityinduced Hog1p phosphorylation and kinaseactivity 0.030480.41758&radic S000003518BIO2YGR286CverifiedBiotin synthase, catalyzes the conversion of dethiobiotin tobiotin, which is the last step of the biotinbiosynthesis pathway; complements E. coli bioBmutant 0.029010.40929&radic S000004376IKI3YLR384CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;maintains structural integrity of Elongator;homolog of human IKAP, mutations in which causefamilial dysautonomia (FD) &radic0.02930.40929&radic&radic&radic S000001341AIR1YIL079CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p to regulate methylationof Npl3p, which modulates Npl3p function inmRNA processing and export; has similarity toAir2p 0.028380.40479&radic&radic&radic S000004849TAF9YMR236WverifiedSubunit (17 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification, similar to histone H3 0.027920.40479&radic S000005816SNF2YOR290CverifiedCatalytic subunit of the SWI/SNF chromatin remodeling complexinvolved in transcriptional regulation;contains DNA-stimulated ATPase activity;functions interdependently in transcriptionalactivation with Snf5p and Snf6p 0.02630.39355 S000000853JHD1YER051WverifiedJmjC domain family histone demethylase specific for H3-K36,similar to proteins found in human, mouse,drosophila, X. laevis, C. elegans, and S. pombe 0.026250.39108&radic S000003080TAF6YGL112CverifiedSubunit (60 kDa) of TFIID and SAGA complexes, involved intranscription initiation of RNA polymerase IIand in chromatin modification, similar tohistone H4 0.025710.38911&radic S000000516SGF29YCL010CverifiedSaGa associated Factor 29kDa; Probable 29kKDa Subunit of SAGAhistone acetyltransferase complex 0.025780.38911&radic&radic&radic S000004106MSL5YLR116WverifiedComponent of the commitment complex, which defines the firststep in the splicing pathway; essential proteinthat interacts with Mud2p and Prp40p, forming abridge between the intron ends; also involvedin nuclear retention of pre-mRNA 0.025120.38461&radic&radic&radic S000004477TAF11YML015CverifiedTFIID subunit (40 kDa), involved in RNA polymerase IItranscription initiation, similar to histone H3with atypical histone fold motif of Spt3-liketranscription factors 0.02420.37639&radic S000002299RPO21YDL140CverifiedRNA polymerase II largest subunit B220, part of central core;phosphorylation of C-terminal heptapeptiderepeat domain regulates association withtranscription and splicing factors; similar tobacterial beta-prime 0.024030.37521&radic S000004045SPT8YLR055CverifiedSubunit of the SAGA transcriptional regulatory complex but notpresent in SAGA-like complex SLIK/SALSA,required for SAGA-mediated inhibition at somepromoters 0.023750.37374&radic&radic&radic&radic S000005722LIP5YOR196CverifiedProtein involved in biosynthesis of the coenzyme lipoic acid,has similarity to E. coli lipoic acid synthase 0.023560.37027&radic S000005533SGT2YOR007CverifiedGlutamine-rich cytoplasmic protein of unknown function;contains tetratricopeptide (TPR) repeats, whichoften mediate protein-protein interactions; hassimilarity to human SGT, which is a cochaperonethat negatively regulates Hsp70 0.023150.3684&radic&radic&radic S000002796RVS167YDR388WverifiedActin-associated protein, subunit of a complex(Rvs161p-Rvs167p) involved in regulation ofactin cytoskeleton, endocytosis, and viabilityfollowing starvation or osmotic stress; homologof mammalian amphiphysin 0.022630.36439&radic&radic S000004564TAF13YML098WverifiedTFIID subunit (19 kDa), involved in RNA polymerase IItranscription initiation, similar to histone H4with atypical histone fold motif of Spt3-liketranscription factors 0.022230.36203&radic S000000183RPL23AYBL087CverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl23Bp and has similarity to E.coli L14 and rat L23 ribosomal proteins 0.021770.35885&radic&radic&radic S000002495SLU7YDR088CverifiedRNA splicing factor, required for ATP-independent portion of2nd catalytic step of spliceosomal RNAsplicing; interacts with Prp18p; contains zincknuckle domain 0.020860.35061&radic&radic S000005932TAF3YPL011CverifiedTFIID subunit (47 kDa), involved in promoter binding and RNApolymerase II transcription initiation 0.019940.3429&radic&radic S000005202DSL1YNL258CverifiedEndoplasmic reticulum (ER)-localized peripheral membraneprotein required for Golgi-to-ER retrogradetraffic; component of the ER target site thatinteracts with coatomer, the major component ofthe COPI vesicle protein coat 0.019880.34096&radic&radic&radic S000003306SMD1YGR074WverifiedCore Sm protein Sm D1; part of heteroheptameric complex (withSmb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D1 0.01980.34096&radic&radic&radic S000004788ECM5YMR176WverifiedNon-essential protein of unknown function, containsATP/GTP-binding site motif A; null mutantexhibits cellular volume up to four timesgreater than wild-type, also large droopingbuds with elongated necks 0.01990.34096 S000006102CTI6YPL181WverifiedProtein that relieves transcriptional repression by binding tothe Cyc8p-Tup1p corepressor and recruiting theSAGA complex to the repressed promoter;contains a PHD finger domain 0.019620.34047 S000003355PPT1YGR123CverifiedProtein serine/threonine phosphatase with similarity to humanphosphatase PP5; present in both the nucleusand cytoplasm; expressed during logarithmicgrowth 0.019430.33852&radic&radic&radic S000005551HST3YOR025WverifiedMember of the Sir2 family of NAD(+)-dependent proteindeacetylases; involved along with Hst4p intelomeric silencing, cell cycle progression,radiation resistance, genomic stability andshort-chain fatty acid metabolism 0.019150.33646&radic&radic S000006128TYW1YPL207WuncharacterizedHypothetical protein 0.018780.33194&radic S000001725YKR017CUncharacterizedPutative protein of unknown function; contains a RING finger motif 0.018640.33194&radic&radic&radic S000005508SPT20YOL148CverifiedSubunit of the SAGA transcriptional regulatory complex,involved in maintaining the integrity of thecomplex 0.01830.32607&radic S000004620YMR018WUncharacterizedPutative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene 0.017730.32346&radic S000005041PHO23YNL097CverifiedProbable component of the Rpd3 histone deacetylase complex,involved in transcriptional regulation of PHO5;C-terminus has similarity to human candidatetumor suppressor p33(ING1) 0.017780.32346 S000001783YKR075CUncharacterizedProtein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p 0.017630.32346&radic&radic S000005199GIS2YNL255CverifiedProtein with seven cysteine-rich CCHC zinc-finger motifs,similar to human CNBP, proposed to be involvedin the RAS/cAMP signaling pathway 0.01770.32346&radic&radic&radic&radic S000002187ARP2YDL029WverifiedEssential component of the Arp2/3 complex, which is a highlyconserved actin nucleation center required forthe motility and integrity of actin patches;involved in endocytosis and membrane growth andpolarity 0.017480.32076 S000005606DIA2YOR080WverifiedOrigin-binding F-box protein that forms an SCF ubiquitin ligasecomplex with Skp1p and Cdc53p; plays a role inDNA replication, involved in invasive andpseudohyphal growth 0.017390.32076&radic&radic S000001542MPE1YKL059CverifiedEssential conserved subunit of CPF (cleavage andpolyadenylation factor), plays a role in 3' endformation of mRNA via the specific cleavage andpolyadenylation of pre-mRNA, contains aputative RNA-binding zinc knuckle motif 0.017280.31766&radic&radic&radic S000003624ARG3YJL088WverifiedOrnithine carbamoyltransferase (carbamoylphosphate:L-ornithinecarbamoyltransferase), catalyzes the sixth stepin the biosynthesis of the arginine precursorornithine 0.016950.31684&radic&radic S000004614CLU1YMR012WverifiedeIF3 component of unknown function; deletion causes defects inmitochondrial organization but not in growth ortranslation initiation, can rescue cytokinesisand mitochondrial organization defects of theDictyostelium cluA- mutant 0.016840.31627&radic&radic&radic S000002835RPN9YDR427WverifiedNon-ATPase regulatory subunit of the 26S proteasome, hassimilarity to putative proteasomal subunits inother species; null mutant is temperaturesensitive and exhibits cell cycle andproteasome assembly defects 0.016780.31427 S000004680RCO1YMR075WverifiedEssential subunit of the histone deacetylase Rpd3S complex;interacts with Eaf3p 0.016680.31427 S000000939YER137CUncharacterizedHypothetical protein 0.016330.31017&radic S000006003MOT1YPL082CverifiedEssential abundant protein involved in regulation oftranscription, removes Spt15p (TBP) from DNAvia its C-terminal ATPase activity, forms acomplex with TBP that binds TATA DNA with highaffinity but with altered specificity 0.016310.31017&radic S000000180CDC27YBL084CverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 0.016150.30861&radic&radic S000000950SPT15YER148WverifiedTATA-binding protein, general transcription factor thatinteracts with other factors to form thepreinitiation complex at promoters, essentialfor viability 0.01620.30861 S000005364SIN3YOL004WverifiedComponent of the Sin3p-Rpd3p histone deacetylase complex,involved in transcriptional repression andactivation of diverse processes, includingmating-type switching and meiosis; involved inthe maintenance of chromosomal integrity 0.015890.3056&radic S000002840NPL3YDR432WverifiedRNA-binding protein that carries poly(A)+ mRNA from the nucleusinto the cytoplasm; phosphorylation by Sky1p inthe cytoplasm may promote release of mRNAs 0.015450.3002&radic&radic S000004334FKS1YLR342WverifiedCatalytic subunit of 1,3-beta-D-glucan synthase, functionallyredundant with alternate catalytic subunitGsc2p; binds to regulatory subunit Rho1p;involved in cell wall synthesis andmaintenance; localizes to sites of cell wallremodeling 0.014920.29625&radic&radic&radic S000000612MAK32YCR019WverifiedProtein necessary for structural stability of L-Adouble-stranded RNA-containing particles 0.014840.29539&radic&radic S000004156SEC10YLR166CverifiedEssential 100kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which has the essential function ofmediating polarized targeting of secretoryvesicles to active sites of exocytosis 0.014710.29261&radic&radic S000004312MMS22YLR320WverifiedProtein involved in resistance to ionizing radiation; acts withMms1p in a repair pathway that may be involvedin resolving replication intermediates orpreventing the damage caused by blockedreplication forks 0.014710.29261&radic&radic S000004623MAC1YMR021CverifiedCopper-sensing transcription factor involved in regulation ofgenes required for high affinity coppertransport 0.01440.28925&radic&radic&radic S000002711RSC3YDR303CverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; essential gene required forregulation of ribosomal protein genes and thecell wall/stress response; highly similar toRsc30p 0.014380.28925&radic&radic S000001046NEM1YHR004CverifiedProtein of the nuclear envelope required for the sphericalshape of the nucleus; required for normalsporulation 0.014470.28925&radic S000000007SPO7YAL009WverifiedIntegral nuclear/ER membrane protein of unknown function,required for normal nuclear envelope morphologyand sporulation 0.014230.28728&radic&radic&radic&radic S000003880JHD2YJR119CuncharacterizedPutative protein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to the cytoplasmand nucleus 0.014220.28728&radic S000006311YTH1YPR107CverifiedEssential RNA-binding component of cleavage and polyadenylationfactor, contains five zinc fingers; requiredfor pre-mRNA 3'-end processing andpolyadenylation 0.014230.28728&radic&radic S000002619GCD6YDR211WverifiedCatalytic epsilon subunit of the translation initiation factoreIF2B, the guanine-nucleotide exchange factorfor eIF2; activity subsequently regulated byphosphorylated eIF2; first identified as anegative regulator of GCN4 expression 0.014270.28728&radic&radic&radic&radic&radic S000001171ARP1YHR129CverifiedActin-related protein of the dynactin complex; required forspindle orientation and nuclear migration;putative ortholog of mammalian centractin 0.013680.28107&radic S000002506BMH2YDR099Wverified14-3-3 protein, minor isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others 0.013360.27697&radic&radic&radic S000006235NTO1YPR031WuncharacterizedComponent of the histone acetyltransferase complex 0.013280.27697&radic S000006393SKI3YPR189WverifiedProtein involved in exosome mediated 3' to 5' mRNA degradationand translation inhibition of non-poly(A)mRNAs; forms complex with Ski2p and Ski8p;required for repressing propagation of dsRNAviruses 0.01330.27697&radic&radic S000001504MAK11YKL021CverifiedProtein essential for cell growth and replication of M dsRNAvirus; contains four beta-transducin repeats 0.01340.27697&radic&radic&radic S000000027MYO4YAL029CverifiedOne of two type V myosin motors (along with MYO2) involved inactin-based transport of cargos; required formRNA transport, including ASH1 mRNA, andfacilitating the growth and movement of ERtubules into the growing bud along with She3p 0.013350.27697&radic&radic&radic S000003945HIF1YLL022CverifiedNon-essential component of the HAT-B histone acetyltransferasecomplex (Hat1p-Hat2p-Hif1p), localized to thenucleus; has a role in telomeric silencing 0.013370.27697 S000002334AIR2YDL175CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p; may regulatemethylation of Npl3p, which modulates Npl3pfunction in mRNA processing and export; hassimilarity to Air1p 0.013420.27697&radic S000001622CTK1YKL139WverifiedCatalytic (alpha) subunit of C-terminal domain kinase I(CTDK-I), which phosphorylates the C-terminalrepeated domain of the RNA polymerase II largesubunit (Rpo21p) to affect both transcriptionand pre-mRNA 3' end processing 0.013170.27549&radic&radic&radic&radic S000004391BDF1YLR399CverifiedProtein involved in transcription initiation at TATA-containingpromoters; associates with the basaltranscription factor TFIID; contains twobromodomains; corresponds to the C-terminalregion of mammalian TAF1; redundant with Bdf2p 0.012910.27231&radic&radic S000000656TAH1YCR060WverifiedHSP90 cofactor; interacts with Hsp82p, Pih1p, Rvb1 and Rvb2,contains a single TPR domain with at least twoTPR motifs 0.012760.26994&radic S000004842RRP5YMR229CverifiedProtein required for the synthesis of both 18S and 5.8S rRNA;C-terminal region is crucial for the formationof 18S rRNA and N-terminal region is requiredfor the 5.8S rRNA; component of small ribosomalsubunit (SSU) processosome 0.012710.26994&radic S000001505CDC16YKL022CverifiedSubunit of the anaphase-promoting complex/cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition; required forsporulation 0.012460.26492&radic&radic&radic S000003502YTA7YGR270WverifiedProtein of unknown function, member of CDC48/PAS1/SEC18 familyof ATPases, potentially phosphorylated byCdc28p 0.012350.26492&radic&radic S000004349RSC2YLR357WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; involvedin telomere maintenance 0.011960.26147&radic S000002594YDR186CUncharacterizedHypothetical protein 0.011860.2592&radic&radic&radic S000003506TAF1YGR274CverifiedTFIID subunit (145 kDa), involved in RNA polymerase IItranscription initiation, has histoneacetyltransferase activity, involved inpromoter binding and G1/S progression &radic0.011440.25452&radic&radic&radic&radic&radic S000005677RPB2YOR151CverifiedRNA polymerase II second largest subunit B150, part of centralcore; similar to bacterial beta subunit 0.011350.25117&radic&radic&radic&radic S000004075ARP6YLR085CverifiedActin-related protein that binds nucleosomes; a component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.01120.25117&radic&radic S000002164PTC1YDL006WverifiedType 2C protein phosphatase (PP2C); inactivates the osmosensingMAPK cascade by dephosphorylating Hog1p;mutation delays mitochondrial inheritance;deletion reveals defects in precursor tRNAsplicing, sporulation and cell separation 0.011180.25117&radic S000000449ISW1YBR245CverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPase thatforms a complex with Ioc2p and Ioc4p toregulate transcription elongation, and acomplex with Ioc3p to repress transcriptioninitiation 0.011390.25117&radic&radic S000000033FUN12YAL035WverifiedGTPase, required for general translation initiation bypromoting Met-tRNAiMet binding to ribosomes andribosomal subunit joining; homolog of bacterialIF2 0.011150.25067&radic&radic S000002198NAT1YDL040CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing &radic0.011130.25067&radic&radic&radic S000005933RRP12YPL012WverifiedProtein required for export of the ribosomal subunits;associates with the RNA components of thepre-ribosomes; contains HEAT-repeats 0.011080.24916&radic&radic&radic S000004607TAF4YMR005WverifiedTFIID subunit (48 kDa), involved in RNA polymerase IItranscription initiation; potential Cdc28psubstrate 0.01110.24916 S000004807RPL36AYMR194WverifiedN-terminally acetylated protein component of the large (60S)ribosomal subunit, nearly identical to Rpl36Bpand has similarity to rat L36 ribosomalprotein; binds to 5.8 S rRNA 0.010880.247&radic&radic&radic S000004582TAF8YML114CverifiedTFIID subunit (65 kDa), involved in RNA polymerase IItranscription initiation 0.01070.24336 S000003957RIX7YLL034CverifiedPutative ATPase of the AAA family, required for export ofpre-ribosomal large subunits from the nucleus;distributed between the nucleolus, nucleoplasm,and nuclear periphery depending on growthconditions 0.010670.24336&radic S000003288RSC1YGR056WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; containstwo essential bromodomains, a bromo-adjacenthomology (BAH) domain, and an AT hook 0.010420.23964&radic&radic S000001716RSC4YKR008WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; found in close proximity tonucleosomal DNA; displaced from the surface ofnucleosomal DNA after chromatin remodeling 0.010410.23964&radic&radic S000002802RPT3YDR394WverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; substrate ofN-acetyltransferase B 0.010340.23916&radic S000003245SNU71YGR013WverifiedComponent of U1 snRNP required for mRNA splicing viaspliceosome; yeast specific, no metazoancounterpart 0.010330.23916&radic&radic&radic&radic S000002800SPT3YDR392WverifiedSubunit of the SAGA and SAGA-like transcriptional regulatorycomplexes, interacts with Spt15p to activatetranscription of some RNA polymeraseII-dependent genes, also functions to inhibittranscription at some promoters 0.010240.23692&radic&radic S000003058LIF1YGL090WverifiedProtein involved in DNA double-strand break repair; physicallyinteracts with DNA ligase 4 (Lig4p); homologousto mammalian XRCC4 protein 0.010170.23685&radic&radic&radic S000005554CIN5YOR028CverifiedBasic leucine zipper transcriptional factor of the yAP-1 familythat mediates pleiotropic drug resistance andsalt tolerance; localizes constitutively to thenucleus 0.009980.23286&radic&radic&radic S000003517ZUO1YGR285CverifiedCytosolic ribosome-associated chaperone that acts, togetherwith Ssz1p and the Ssb proteins, as a chaperonefor nascent polypeptide chains; contains a DnaJdomain and functions as a J-protein partner forSsb1p and Ssb2p 0.009970.23286&radic S000001537DEF1YKL054CverifiedRNAPII degradation factor, forms a complex with Rad26p inchromatin, enables ubiquitination andproteolysis of RNAPII present in an elongationcomplex 0.009980.23286&radic&radic&radic&radic S000004802SGS1YMR190CverifiedNucleolar DNA helicase of the RecQ family involved inmaintenance of genome integrity, regulateschromosome synapsis and meiotic crossing over;has similarity to human BLM and WRN helicasesimplicated in Bloom and Werner syndromes 0.009850.23051&radic&radic&radic&radic&radic S000003162HOS2YGL194CverifiedHistone deacetylase required for gene activation via specificdeacetylation of lysines in H3 and H4 histonetails; subunit of the Set3 complex, ameiotic-specific repressor of sporulationspecific genes that contains deacetylaseactivity 0.009650.22804&radic&radic&radic&radic S000003326VAS1YGR094WverifiedMitochondrial and cytoplasmic valyl-tRNA synthetase 0.009670.22804&radic&radic&radic&radic&radic S000006059SPP1YPL138CverifiedSubunit of COMPASS (Set1C), a complex which methylates histoneH3 on lysine 4 and is required in telomerictranscriptional silencing; PHD finger domainprotein similar to human CGBP, an unmethylatedCpG binding protein 0.009780.22804 S000003481MGA1YGR249WverifiedProtein similar to heat shock transcription factor; multicopysuppressor of pseudohyphal growth defects ofammonium permease mutants 0.009660.22804&radic&radic S000006156RVB2YPL235WverifiedEssential protein involved in transcription regulation;component of chromatin remodeling complexes;required for assembly and function of the INO80complex; member of the RUVB-like protein family 0.009570.22698&radic&radic&radic S000005205ORC5YNL261WverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing 0.009570.22678&radic&radic S000004818PFK2YMR205CverifiedBeta subunit of heterooctameric phosphofructokinase involved inglycolysis, indispensable for anaerobic growth,activated by fructose-2,6-bisphosphate and AMP,mutation inhibits glucose induction of cellcycle-related genes 0.009550.22647&radic&radic S000005643RPT5YOR117WverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; recruited to theGAL1-10 promoter region upon induction oftranscription 0.009540.22642&radic&radic S000002987CKB1YGL019WverifiedBeta regulatory subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKA2 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.009490.22372&radic&radic S000003472PFK1YGR240CverifiedAlpha subunit of heterooctameric phosphofructokinase involvedin glycolysis, indispensable for anaerobicgrowth, activated by fructose-2,6-bisphosphateand AMP, mutation inhibits glucose induction ofcell cycle-related genes 0.00940.22372&radic&radic S000006048HHO1YPL127CverifiedHistone H1, a linker histone required for nucleosome packagingat restricted sites; suppresses DNA repairinvolving homologous recombination; notrequired for telomeric silencing, basaltranscriptional repression, or efficientsporulation 0.009360.22348&radic&radic S000005651CAT5YOR125CverifiedMitochondrial inner membrane protein directly involved inubiquinone biosynthesis, essential for severalother metabolic pathways including respirationand gluconeogenic gene activation 0.009350.22348&radic&radic&radic S000005372HTZ1YOL012CverifiedHistone variant H2AZ, exchanged for histone H2A in nucleosomesby the SWR1 complex; involved intranscriptional regulation through preventionof the spread of silent heterochromatin 0.009330.22287&radic&radic S000005415PSH1YOL054WuncharacterizedNuclear protein, putative RNA polymerase II elongation factor;isolated as Pob3p/Spt16p-binding protein 0.009310.2228&radic&radic S000003234SWC4YGR002CverifiedProtein of unknown function, component of the Swr1p complexthat incorporates Htz1p into chromatin;component of the NuA4 histone acetyltransferasecomplex 0.009270.22059&radic&radic S000002483RAD55YDR076WverifiedProtein that stimulates strand exchange by stabilizing thebinding of Rad51p to single-stranded DNA;involved in the recombinational repair ofdouble-strand breaks in DNA during vegetativegrowth and meiosis; forms heterodimer withRad57p 0.00910.21882&radic&radic&radic&radic S000003977YLL054CUncharacterizedPutative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene 0.009080.21791&radic&radic&radic&radic S000002603REF2YDR195WverifiedRNA-binding protein involved in the cleavage step of mRNA3'-end formation prior to polyadenylation, andin snoRNA maturation; part of holo-CPFsubcomplex APT, which associates with 3'-endsof snoRNA- and mRNA-encoding genes 0.009090.21791&radic&radic S000004157RPS31YLR167WverifiedFusion protein that is cleaved to yield a ribosomal protein ofthe small (40S) subunit and ubiquitin;ubiquitin may facilitate assembly of theribosomal protein into ribosomes; interactsgenetically with translation factor eIF2B 0.009030.21633&radic S000003099SNT2YGL131CverifiedDNA binding protein with similarity to the S. pombe Snt2protein 0.009010.21633&radic S000000689CDC39YCR093WverifiedComponent of the CCR4-NOT complex, which has multiple roles inregulating mRNA levels including regulation oftranscription and destabilizing mRNAs bydeadenylation; basal transcription factor 0.008970.21633&radic&radic&radic&radic S000003507RTT102YGR275WverifiedComponent of both the SWI/SNF and RSC chromatin remodelingcomplexes, suggested role in chromosomemaintenance; possible weak regulator of Ty1transposition 0.008960.21589&radic&radic&radic S000002451HEM13YDR044WverifiedCoproporphyrinogen III oxidase, an oxygen requiring enzyme thatcatalyzes the sixth step in the hemebiosynthetic pathway; localizes to themitochondrial inner membrane; transcription isrepressed by oxygen and heme (via Rox1p andHap1p) 0.008930.21542&radic&radic S000001209CDC23YHR166CverifiedSubunit of the anaphase-promoting complex/cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 0.008910.21542 S000004839TMA29YMR226CverifiedNADP(+)-dependent dehydrogenase; acts on serine,L-allo-threonine, and other 3-hydroxy acids;green fluorescent protein fusion proteinlocalizes to the cytoplasm and nucleus; mayinteract with ribosomes, based onco-purification experiments 0.008570.20873&radic&radic&radic&radic S000003826ARP3YJR065CverifiedEssential component of the Arp2/3 complex, which is a highlyconserved actin nucleation center required forthe motility and integrity of actin patches;involved in endocytosis and membrane growth andpolarity 0.008510.20686 S000000211DSF2YBR007CuncharacterizedDeletion suppressor of mpt5 mutation 0.008510.20686 S000006345KAR3YPR141CverifiedMinus-end-directed microtubule motor that functions in mitosisand meiosis, localizes to the spindle pole bodyand localization is dependent on functionalCik1p, required for nuclear fusion duringmating; potential Cdc28p substrate 0.00850.20686&radic&radic&radic S000000015PSK1YAL017WverifiedOne of two (see also PSK2) PAS domain containing S/T proteinkinases; coordinately regulates proteinsynthesis and carbohydrate metabolism andstorage in response to a unknown metabolitethat reflects nutritional status 0.008440.20662&radic&radic S000004279MEC3YLR288CverifiedDNA damage and meiotic pachytene checkpoint protein; subunit ofa heterotrimeric complex (Rad17p-Mec3p-Ddc1p)that forms a sliding clamp, loaded onto partialduplex DNA by a clamp loader complex; homologof human and S. pombe Hus1 0.008240.20284&radic&radic&radic S000001335SPO22YIL073CverifiedMeiosis-specific protein essential for chromosome synapsis,similar to phospholipase A2, involved incompletion of nuclear divisions during meiosis;induced early in meiosis 0.008270.20284&radic&radic S000001338SEC28YIL076WverifiedEpsilon-COP subunit of the coatomer; regulates retrogradeGolgi-to-ER protein traffic; stabilizes Cop1p,the alpha-COP and the coatomer complex;non-essential for cell growth 0.008280.20284&radic&radic&radic S000004230VPS34YLR240WverifiedPhosphatidylinositol 3-kinase responsible for the synthesis ofphosphatidylinositol 3-phosphate; formsmembrane-associated signal transduction complexwith Vps15p to regulate protein sorting;activated by the GTP-bound form of Gpa1p 0.008250.20284&radic S000001333PCI8YIL071CverifiedPossible shared subunit of Cop9 signalosome (CSN) and eIF3,binds eIF3b subunit Prt1p, has possible dualfunctions in transcriptional and translationalcontrol, contains a PCI (Proteasome-COP9signalosome (CSN)-eIF3) domain 0.008160.20192&radic&radic&radic&radic S000005180SIN4YNL236WverifiedSubunit of the Mediator complex; interacts with the RNApolymerase II holoenzyme to postively ornegatively regulate transcription; dispensiblefor basal transcription 0.007990.19915&radic&radic&radic S000000154SHP1YBL058WverifiedUBX (ubiquitin regulatory X) domain-containing protein thatregulates Glc7p phosphatase activity andinteracts with Cdc48p; interacts withubiquitylated proteins in vivo and is requiredfor degradation of a ubiquitylated modelsubstrate 0.008040.19915&radic&radic S000000165AST1YBL069WverifiedPeripheral membrane protein that interacts with the plasmamembrane ATPase Pma1p and has a role in itstargeting to the plasma membrane, possibly byinfluencing its incorporation into lipid rafts 0.007950.19862&radic&radic&radic S000004255NEJ1YLR265CverifiedProtein involved in regulation of nonhomologous end joining;repressed by MAT heterozygosity; associateswith Lif1p and regulates its cellulardistribution 0.007870.1972&radic&radic&radic S000001526PHD1YKL043WverifiedTranscriptional activator that enhances pseudohyphal growth;regulates expression of FLO11, an adhesinrequired for pseudohyphal filament formation;similar to StuA, an A. nidulans developmentalregulator; potential Cdc28p substrate 0.007840.19683&radic&radic&radic&radic S000000157SKT5YBL061CverifiedActivator of Chs3p (chitin synthase III), recruits Chs3p to thebud neck via interaction with Bni4p; hassimilarity to Shc1p, which activates Chs3pduring sporulation 0.007840.19683&radic&radic S000006049TBF1YPL128CverifiedTelobox-containing general regulatory factor; binds to TTAGGGrepeats within subtelomeric anti-silencingregions (STARs) and possibly throughout thegenome and mediates their insulating capacityby blocking silent chromatin propagation 0.007790.19606 S000000125YBL029WUncharacterizedHypothetical protein 0.007740.19466&radic&radic S000004166RFX1YLR176CverifiedProtein involved in DNA damage and replication checkpointpathway; recruits repressors Tup1p and Cyc8p topromoters of DNA damage-inducible genes;similar to a family of mammalian DNA bindingRFX1-4 proteins 0.00770.19428&radic&radic S000001527YKL044WDubiousHypothetical protein 0.007680.19428&radic S000002589SAS4YDR181CverifiedSubunit of the SAS complex (Sas2p, Sas4p, Sas5p), whichacetylates free histones and nucleosomes andregulates transcriptional silencing; requiredfor the HAT activity of Sas2p &radic0.007670.1942&radic&radic&radic&radic S000004133YLR143WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; YLR143W is not an essential gene 0.007680.1942&radic&radic&radic&radic&radic S000005607TGL5YOR081CverifiedTriacylglycerol lipase involved in TAG mobilization; localizesto lipid particles; potential Cdc28p substrate 0.007610.19301&radic&radic S000003956IRC19YLL033WuncharacterizedPutative protein of unknown function; YLL033W is not anessential gene but mutant is defective in sporeformation; null mutant displays increasedlevels of spontaneous Rad52 foci 0.007620.19301 S000003641SET4YJL105WverifiedProtein of unknown function, contains a SET domain 0.00760.19253 S000005550IRC12YOR024WdubiousHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 0.007440.19008&radic S000003924DNM1YLL001WverifiedDynamin-related GTPase required for mitochondrial fission andthe maintenance of mitochondrial morphology,assembles on the cytoplasmic face ofmitochondrial tubules at sites at whichdivision will occur; also participates inendocytosis 0.007410.18924&radic S000005667ARP8YOR141CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes 0.007320.18734&radic S000004530ORC1YML065WverifiedLargest subunit of the origin recognition complex, whichdirects DNA replication by binding toreplication origins and is also involved intranscriptional silencing; may bephosphorylated by Cdc28p 0.007270.18582&radic S000002624ADR1YDR216WverifiedCarbon source-responsive zinc-finger transcription factor,required for transcription of theglucose-repressed gene ADH2, of peroxisomalprotein genes, and of genes required forethanol, glycerol, and fatty acid utilization 0.007250.18582&radic&radic&radic S000000099HTA2YBL003CverifiedOne of two nearly identical (see also HTA1) histone H2Asubtypes; core histone required for chromatinassembly and chromosome function; DNAdamage-dependent phosphorylation by Mec1pfacilitates DNA repair; acetylated by Nat4p 0.007090.18319&radic S000001488BYE1YKL005CverifiedNegative regulator of transcription elongation, contains aTFIIS-like domain and a PHD finger, multicopysuppressor of temperature-sensitive ess1mutations, probably binds RNA polymerase IIlarge subunit 0.007110.18319 S000002633HTA1YDR225WverifiedOne of two nearly identical (see also HTA2) histone H2Asubtypes; core histone required for chromatinassembly and chromosome function; DNAdamage-dependent phosphorylation by Mec1pfacilitates DNA repair; acetylated by Nat4p 0.007090.18319&radic S000005549AHC1YOR023CverifiedSubunit of the Ada histone acetyltransferase complex, requiredfor structural integrity of the complex &radic0.007030.18214&radic&radic&radic&radic S000000735GCN4YEL009CverifiedTranscriptional activator of amino acid biosynthetic genes inresponse to amino acid starvation; expressionis tightly regulated at both thetranscriptional and translational levels 0.006980.18016&radic&radic S000001388STH1YIL126WverifiedATPase component of the ATP-dependent RSC chromatin remodelingcomplex required for kinetochore function inchromosome segregation; required for expressionof early meiotic genes; essentialhelicase-related protein homologous to Snf2p 0.0070.18016 S000001737SET3YKR029CverifiedDefining member of the SET3 histone deacetylase complex whichis a meiosis-specific repressor of sporulationgenes; necessary for efficient transcription byRNAPII; one of two yeast proteins that containsboth SET and PHD domains 0.006940.18016 S000004645ARG80YMR042WverifiedTranscription factor involved in regulation ofarginine-responsive genes; acts with Arg81p andArg82p 0.006880.17829&radic&radic&radic S000003034SGF73YGL066Wverified73 kDa subunit of SAGA histone acetyltransferase complex;involved in formation of the preinitiationcomplex assembly at promoters &radic0.006810.17791&radic&radic&radic&radic S000001871BUD27YFL023WverifiedProtein involved in bud-site selection, nutrient signaling, andgene expression controlled by the TOR kinase;diploid mutants display a random buddingpattern instead of the wild-type bipolarpattern 0.006770.17666&radic&radic S000003651ASF1YJL115WverifiedNucleosome assembly factor, involved in chromatin assembly anddisassembly, anti-silencing protein that causesderepression of silent loci when overexpressed 0.006760.17666 S000000213HHF1YBR009CverifiedOne of two identical histone H4 proteins (see also HHF2); corehistone required for chromatin assembly andchromosome function; contributes to telomericsilencing; N-terminal domain involved inmaintaining genomic integrity 0.006760.17666 S000005436MDM20YOL076WverifiedNon-catalytic subunit of the NatB N-terminal acetyltransferase,which catalyzes acetylation of theamino-terminal methionine residues of allproteins beginning with Met-Asp or Met-Glu andof some proteins beginning with Met-Asn orMet-Met; involved in mitochondrial inheritanceand actin assembly &radic0.006750.17666&radic&radic&radic&radic S000002493SSS1YDR086CverifiedSubunit of the Sec61p translocation complex(Sec61p-Sss1p-Sbh1p) that forms a channel forpassage of secretory proteins through theendoplasmic reticulum membrane, and of theSsh1p complex (Ssh1p-Sbh2p-Sss1p); interactswith Ost4p and Wbp1p 0.006750.17639 S000005257YNL313CUncharacterizedProtein required for cell viability 0.006690.1752&radic&radic&radic S000006386SMX3YPR182WverifiedCore Sm protein Sm F; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm F 0.006680.1752&radic&radic S000001609YPK1YKL126WverifiedSerine/threonine protein kinase required for receptor-mediatedendocytosis; involved in sphingolipid-mediatedand cell integrity signaling pathways;localized to the bud neck, cytosol and plasmamembrane; homolog of mammalian kinase SGK 0.006670.17302&radic&radic&radic&radic S000005828YOR302WVerifiedCPA1 uORF , Arginine attenuator peptide, regulates translation of the CPA1 mRNA 0.00660.17302&radic S000000885GET2YER083CverifiedSubunit of the GET complex; required for meiotic nucleardivision and for the retrieval of HDEL proteinsfrom the Golgi to the ER in an ERD2 dependentfashion; may be involved in cell wall function 0.006550.17258&radic&radic S000003332MDR1YGR100WverifiedCytoplasmic GTPase-activating protein for Ypt/Rab transportGTPases Ypt6p, Ypt31p and Sec4p; involved inrecycling of internalized proteins andregulation of Golgi secretory function 0.006550.17258&radic&radic S000003730CDC6YJL194WverifiedEssential ATP-binding protein required for DNA replication,component of the pre-replicative complex(pre-RC) which requires ORC to associate withchromatin and is in turn required for Mcm2-7pDNA association; homologous to S. pombe Cdc18p 0.006430.1702&radic&radic&radic S000005829CPA1YOR303WverifiedSmall subunit of carbamoyl phosphate synthetase, whichcatalyzes a step in the synthesis ofcitrulline, an arginine precursor;translationally regulated by an attenuatorpeptide encoded by YOR302W within the CPA1 mRNA5'-leader 0.00640.16913&radic S000005715IES4YOR189WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.006390.16913&radic&radic&radic S000001593KTI12YKL110CverifiedProtein that plays a role, with Elongator complex, inmodification of wobble nucleosides in tRNA;involved in sensitivity to G1 arrest induced byzymocin; interacts with chromatin throughoutthe genome; also interacts with Cdc19p 0.006350.1685&radic&radic&radic S000003949HSP104YLL026WverifiedHeat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p(Hsp70) to refold and reactivate previouslydenatured, aggregated proteins; responsive tostresses including: heat, ethanol, and sodiumarsenite; involved in [PSI+] propagation 0.006330.16803&radic&radic&radic&radic S000005888PRT1YOR361CverifiedSubunit of the core complex of translation initiation factor3(eIF3), essential for translation; part of asubcomplex (Prt1p-Rpg1p-Nip1p) that stimulatesbinding of mRNA and tRNA(i)Met to ribosomes 0.006260.1666&radic&radic&radic&radic S000001650MRP49YKL167CverifiedMitochondrial ribosomal protein of the large subunit, notessential for mitochondrial translation 0.006250.16627&radic S000001197RTT107YHR154WverifiedProtein implicated in Mms22-dependent DNA repair during Sphase, DNA damage induces phosphorylation byMec1p at one or more SQ/TQ motifs; interactswith Mms22p and Slx4p; has four BRCT domains;has a role in regulation of Ty1 transposition 0.006250.16627 S000005991MUK1YPL070WuncharacterizedProtein of unknown function, localized to the cytoplasm;computational analysis of large-scaleprotein-protein interaction data suggests apossible role in transcriptional regulation 0.006210.16563&radic&radic&radic S000001566YKL083WDubiousDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14 0.006150.16432&radic&radic&radic&radic S000002255RPN6YDL097CverifiedEssential, non-ATPase regulatory subunit of the 26S proteasomelid required for the assembly and activity ofthe 26S proteasome; the human homolog (S9protein) partially rescues Rpn6p depletion 0.006050.16123&radic S000004239YEF3YLR249WverifiedTranslational elongation factor, stimulates the binding ofaminoacyl-tRNA (AA-tRNA) to ribosomes byreleasing EF-1 alpha from the ribosomalcomplex; contains two ABC cassettes; binds andhydrolyses ATP 0.006110.16123&radic S000005553STI1YOR027WverifiedHsp90 cochaperone, interacts with the Ssa group of thecytosolic Hsp70 chaperones; activates theATPase activity of Ssa1p; homolog of mammalianHop protein 0.005990.16031&radic&radic&radic S000005216SEC2YNL272CverifiedGuanyl-nucleotide exchange factor for the small G-proteinSec4p, located on cytoplasmic vesicles;essential for post-Golgi vesicle transport 0.005990.16031&radic&radic&radic S000000019CCR4YAL021CverifiedComponent of the CCR4-NOT transcriptional complex, which isinvolved in regulation of gene expression;component of the major cytoplasmic deadenylase,which is involved in mRNA poly(A) tailshortening 0.0060.16031&radic&radic&radic S000004107CLF1YLR117CverifiedEssential splicesome assembly factor; contains multipletetratricopeptide repeat (TPR) protein-bindingmotifs and interacts specifically with manyspliceosome components, may serve as a scaffoldduring splicesome assembly 0.005970.16015&radic&radic S000001762DYN1YKR054CverifiedCytoplasmic heavy chain dynein, microtubule motor protein,required for anaphase spindle elongation;involved in spindle assembly, chromosomemovement, and spindle orientation during celldivision, targeted to microtubule tips by Pac1p 0.005930.15814&radic&radic S000002568YDR161WUncharacterizedinteracts with PP2C 0.005910.15814&radic&radic&radic S000006125HRR25YPL204WverifiedProtein kinase involved in regulating diverse events includingvesicular trafficking, gene expression, DNArepair, and chromosome segregation; binds theCTD of RNA pol II; homolog of mammalian caseinkinase 1delta (CK1delta) 0.005930.15814&radic S000005210YNL266WDubiousHypothetical protein 0.005850.15708&radic&radic&radic&radic S000003210KAP114YGL241WverifiedKaryopherin, responsible for nuclear import of Spt15p, histonesH2A and H2B, and Nap1p; amino terminus showssimilarity to those of other importins,particularly Cse1p; localization is primarilynuclear 0.005860.15708&radic&radic&radic S000004170SAM1YLR180WverifiedS-adenosylmethionine synthetase, catalyzes transfer of theadenosyl group of ATP to the sulfur atom ofmethionine; one of two differentially regulatedisozymes (Sam1p and Sam2p) 0.005840.15678&radic&radic S000005968SGF11YPL047WverifiedIntegral subunit of SAGA histone acetyltransferase complex,regulates transcription of a subset ofSAGA-regulated genes, required for the Ubp8passociation with SAGA and for H2Bdeubiquitylation 0.005830.15654&radic S000003175SPT16YGL207WverifiedSubunit of the heterodimeric FACT complex (Spt16p-Pob3p),facilitates RNA Polymerase II transcriptionelongation through nucleosomes by destabilizingand then reassembling nucleosome structure 0.005810.15631&radic S000005583SGT1YOR057WverifiedProbable cochaperone, regulates activity of Cyr1p (adenylylcyclase); involved in assembly of thekinetochore complex, associates with the SCF(Skp1p/Cdc53p/F box protein) ubiquitin ligasecomplex 0.005790.15567&radic&radic&radic S000001138HXT5YHR096CverifiedHexose transporter with moderate affinity for glucose, inducedin the presence of non-fermentable carbonsources, induced by a decrease in growth rate,contains an extended N-terminal domain relativeto other HXTs 0.005790.15567&radic S000005211PIK1YNL267WverifiedPhosphatidylinositol 4-kinase; catalyzes first step in thebiosynthesis ofphosphatidylinositol-4,5-biphosphate; maycontrol cytokineses through the actincytoskeleton 0.005780.15567&radic S000005608YOR082CDubiousHypothetical protein 0.005750.15445&radic&radic&radic S000000870MOT2YER068WverifiedComponent of the CCR4-NOT complex, which has multiple roles intranscription regulation, mRNA degradation, andpost-transcriptional modifications; with Ubc4p,ubiquitylates subunits of the nascentpolypeptide-associated complex (NAC) 0.005740.15445&radic&radic&radic S000005274RPD3YNL330CverifiedHistone deacetylase; regulates transcription and silencing 0.005760.15445&radic S000004565ARG81YML099CverifiedZinc-finger transcription factor of the Zn(2)-Cys(6) binuclearcluster domain type, involved in the regulationof arginine-responsive genes; acts with Arg80pand Arg82p 0.005750.15445&radic S000001541TOA2YKL058WverifiedTFIIA small subunit; involved in transcriptional activation,acts as antirepressor or as coactivator;homologous to smallest subunit of human andDrosophila TFIIA 0.005710.15364&radic&radic S000001676SDS22YKL193CverifiedConserved nuclear regulatory subunit of Glc7p type 1 proteinserine-threonine phosphatase (PP1), functionspositively with Glc7p to promotedephosphorylation of nuclear substratesrequired for chromosome transmission duringmitosis 0.005620.15084&radic&radic&radic&radic S000003059NBP35YGL091CverifiedEssential P-loop NTPase that functions in nuclear and cytosoliciron-sulfur (FeS) protein assembly; has ahighly conserved N-terminus 0.005610.15084&radic&radic&radic&radic S000004159YLR169WDubiousHypothetical protein 0.005560.14995&radic&radic&radic S000001029YHL037CDubiousHypothetical protein 0.005560.1499&radic&radic&radic S000002553SWI5YDR146CverifiedTranscription factor that activates transcription of genesexpressed at the M/G1 phase boundary and in G1phase; localization to the nucleus occursduring G1 and appears to be regulated byphosphorylation by Cdc28p kinase 0.005540.14955&radic&radic&radic&radic S000002635SIR4YDR227WverifiedSilent information regulator that, together with SIR2 and SIR3,is involved in assembly of silent chromatindomains at telomeres and the silent mating-typeloci; potentially phosphorylated by Cdc28p;some alleles of SIR4 prolong lifespan 0.005550.14955&radic&radic&radic S000004976HHT2YNL031CverifiedOne of two identical histone H3 proteins (see also HHT1); corehistone required for chromatin assembly,involved in heterochromatin-mediated telomericand HM silencing; regulated by acetylation,methylation, and mitotic phosphorylation 0.005550.14955 S000002172NOP1YDL014WverifiedNucleolar protein, component of the small subunit processomecomplex, which is required for processing ofpre-18S rRNA; has similarity to mammalianfibrillarin 0.005480.1479 S000005500ARG8YOL140WverifiedAcetylornithine aminotransferase, catalyzes the fourth step inthe biosynthesis of the arginine precursorornithine 0.005510.1479 S000002842GPI17YDR434WverifiedTransmembrane protein subunit of theglycosylphosphatidylinositol transamidasecomplex that adds GPIs to newly synthesizedproteins; human PIG-Sp homolog 0.005510.1479 S000003430YPP1YGR198WverifiedCargo-transport protein involved in endocytosis; may interactwith ribosomes, based on co-purificationexperiments; GFP-fusion protein localizes tothe cytoplasm; YGR198W is an essential gene 0.005520.1479&radic&radic S000002134FUN19YAL034CverifiedNon-essential protein of unknown function 0.005510.1479&radic S000002789YRA1YDR381WverifiedNuclear protein that binds to RNA and to Mex67p, required forexport of poly(A)+ mRNA from the nucleus;member of the REF (RNA and export factorbinding proteins) family; another familymember, Yra2p, can substitute for Yra1pfunction 0.005430.14592&radic&radic S000005217TOF1YNL273WverifiedSubunit of a replication-pausing checkpoint complex(Tof1p-Mrc1p-Csm3p) that acts at the stalledreplication fork to promote sister chromatidcohesion after DNA damage, facilitating gaprepair of damaged DNA; interacts with the MCMhelicase 0.00540.14592&radic&radic S000005168SQS1YNL224CverifiedProtein of unknown function; overexpression antagonizes thesuppression of splicing defects by spp382mutants; green fluorescent protein (GFP)-fusionprotein localizes to both the cytoplasm and thenucleus 0.005370.14519&radic&radic&radic S000005527RRP6YOR001WverifiedExonuclease component of the nuclear exosome; contributes tothe quality-control system that retains anddegrades aberrant mRNAs in the nucleus 0.005380.14519&radic&radic&radic S000001163LSM12YHR121WverifiedProtein of unknown function that interacts with Pbp1p and Pbp4pand associates with ribosomes; contains anRNA-binding LSM domain and an AD domain; mayplay a role in RNA processing 0.005360.14468&radic&radic&radic&radic S000001863HAC1YFL031WverifiedbZIP transcription factor (ATF/CREB1 homolog) that regulatesthe unfolded protein response, via UPREbinding, and membrane biogenesis; ERstress-induced splicing pathway utilizingIre1p, Trl1p and Ada5p facilitates efficientHac1p synthesis 0.005370.14468&radic&radic&radic S000001756NAP1YKR048CverifiedProtein that interacts with mitotic cyclin Clb2p; required forthe regulation of microtubule dynamics duringmitosis; controls bud morphogenesis; involvedin the transport of H2A and H2B histones to thenucleus 0.005330.14409&radic&radic S000001121IRE1YHR079CverifiedSerine-threonine kinase and endoribonuclease; transmembraneprotein that initiates the unfolded proteinresponse signal by regulating synthesis ofHac1p through HAC1 mRNA splicing 0.005330.14409&radic&radic S000004876SAP30YMR263WverifiedSubunit of a histone deacetylase complex, along with Rpd3p andSin3p, that is involved in silencing attelomeres, rDNA, and silent mating-type loci;involved in telomere maintenance 0.005340.14409&radic S000001160ORC6YHR118CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing; may be phosphorylated by Cdc28p 0.00530.14305&radic&radic&radic S000000111ACH1YBL015WverifiedAcetyl-coA hydrolase, primarily localized to mitochondria;required for acetate utilization and fordiploid pseudohyphal growth 0.005280.14244&radic&radic&radic S000005739SAS5YOR213CverifiedSubunit of the SAS complex (Sas2p, Sas4p, Sas5p), whichacetylates free histones and nucleosomes andregulates transcriptional silencing; stimulatesSas2p HAT activity &radic0.005260.14218&radic&radic&radic S000005004ARP5YNL059CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes 0.005250.14178&radic S000005014TOM7YNL070WverifiedComponent of the TOM (translocase of outer membrane) complexresponsible for recognition and initial importsteps for all mitochondrially directedproteins; promotes assembly and stability ofthe TOM complex 0.005240.14162 S000004277YLR287CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene 0.005230.14141&radic S000006005BRO1YPL084WverifiedCytoplasmic class E vacuolar protein sorting (VPS) factor thatcoordinates deubiquitination in themultivesicular body (MVB) pathway by recruitingDoa4p to endosomes 0.005220.14111&radic&radic&radic S000006169GAL4YPL248CverifiedDNA-binding transcription factor required for the activation ofthe GAL genes in response to galactose;repressed by Gal80p and activated by Gal3p 0.005220.14111&radic S000004887RCE1YMR274CverifiedType II CAAX prenyl protease involved in the proteolysis andmaturation of Ras and the a-factor matingpheromone 0.005190.14033&radic S000003636LSB6YJL100WverifiedPhosphatidylinositol 4-kinase that binds Las17p, which is ahomolog of human Wiskott-Aldrich Syndromeprotein involved in actin patch assembly andactin polymerization 0.005180.13984 S000006131SRP72YPL210CverifiedCore component of the signal recognition particle (SRP)ribonucleoprotein (RNP) complex that functionsin targeting nascent secretory proteins to theendoplasmic reticulum (ER) membrane 0.005170.13984&radic S000000214HHT1YBR010WverifiedOne of two identical histone H3 proteins (see also HHT2); corehistone required for chromatin assembly,involved in heterochromatin-mediated telomericand HM silencing; regulated by acetylation,methylation, and mitotic phosphorylation 0.005180.13984 S000000782HAT2YEL056WverifiedSubunit of the Hat1p-Hat2p histone acetyltransferase complex;required for high affinity binding of thecomplex to free histone H4, thereby enhancingHat1p activity; similar to human RbAp46 and 48;has a role in telomeric silencing &radic0.005170.13968&radic S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.005150.13915&radic&radic&radic S000003464NAS6YGR232WverifiedRegulatory, non-ATPase subunit of the 26S proteasome; homologof the human oncoprotein gankyrin, whichinteracts with the retinoblastoma tumorsuppressor (Rb) and cyclin-dependent kinase 4/6 0.005080.13718&radic&radic S000005587CKA2YOR061WverifiedAlpha' catalytic subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKB1 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.005080.13718&radic&radic&radic S000003964SDH2YLL041CverifiedIron-sulfur protein subunit of succinate dehydrogenase (Sdh1p,Sdh2p, Sdh3p, Sdh4p), which couples theoxidation of succinate to the transfer ofelectrons to ubiquinone 0.005120.13718 S000000513YCL007CDubiousDubious ORF unlikely to encode a protein; overlaps verified ORF YCL005W-A; mutations in YCL007C were thought to confer sensitivity to calcofluor white, but this phenotype was later shown to be due to the defect in YCL005W-A 0.005130.13718&radic S000004798HSC82YMR186WverifiedCytoplasmic chaperone of the Hsp90 family, redundant infunction and nearly identical with Hsp82p, andtogether they are essential; expressedconstitutively at 10-fold higher basal levelsthat HSP82 and induced 2-3 fold by heat shock 0.00510.13718&radic&radic S000003723SWE1YJL187CverifiedProtein kinase that regulates the G2/M transition by inhibitionof Cdc28p kinase activity; localizes to thenucleus and to the daughter side of themother-bud neck; homolog of S. pombe Wee1p;potential Cdc28p substrate 0.005090.13718&radic&radic&radic&radic S000001906UBP6YFR010WverifiedUbiquitin-specific protease situated in the base subcomplex ofthe 26S proteasome, releases free ubiquitinfrom branched polyubiquitin chains; deletioncauses hypersensitivity to cycloheximide andother toxic compounds 0.005090.13718&radic&radic&radic&radic S000001616YKL133CUncharacterizedHypothetical protein 0.005030.13534&radic&radic&radic S000001709VPS1YKR001CverifiedGTPase required for vacuolar protein sorting, functions inactin cytoskeleton organization via itsinteraction with Sla1p; required for lateGolgi-retention of some proteins includingKex2p; involved in regulating peroxisomebiogenesis 0.004990.13433&radic&radic&radic S000003213RTF1YGL244WverifiedSubunit of the RNA polymerase II-associated Paf1 complex;directly or indirectly regulates DNA-bindingproperties of Spt15p and relative activities ofdifferent TATA elements; involved in telomeremaintenance 0.004990.13433&radic&radic S000003738YJL202CDubiousHypothetical protein; open reading frame overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex 0.004990.13433&radic&radic&radic&radic S000000009SWC3YAL011WverifiedProtein of unknown function, component of the SWR1 complex,which exchanges histone variant H2AZ (Htz1p)for chromatin-bound histone H2A; required forformation of nuclear-associated array of smoothendoplasmic reticulum known as karmellae 0.0050.13433&radic S000003746PEX2YJL210WverifiedRING-finger peroxin, peroxisomal membrane protein with aC-terminal zinc-binding RING domain, formsputative translocation subcomplex with Pex10pand Pex12p which functions in peroxisomalmatrix protein import 0.004960.13329&radic S000000011DEP1YAL013WverifiedTranscriptional modulator involved in regulation of structuralphospholipid biosynthesis genes andmetabolically unrelated genes, as well asmaintenance of telomeres, mating efficiency,and sporulation 0.004960.13329&radic&radic S000000119MCM2YBL023CverifiedProtein involved in DNA replication; component of the Mcm2-7hexameric complex that binds chromatin as apart of the pre-replicative complex 0.004940.13197&radic&radic S000002904PUF6YDR496CverifiedPumilio-homology domain protein that binds ASH1 mRNA at PUFconsensus sequences in the 3' UTR and repressesits translation, resulting in proper asymmetriclocalization of ASH1 mRNA 0.004930.13197 S000002538YDR131CUncharacterizedF-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex 0.004930.13197&radic S000001587GFA1YKL104CverifiedGlutamine-fructose-6-phosphate amidotransferase, catalyzes theformation of glucosamine-6-P and glutamate fromfructose-6-P and glutamine in the first step ofchitin biosynthesis 0.004890.13141&radic&radic S000004172SWI6YLR182WverifiedTranscription cofactor, forms complexes with DNA-bindingproteins Swi4p and Mbp1p to regulatetranscription at the G1/S transition; involvedin meiotic gene expression; localizationregulated by phosphorylation; potential Cdc28psubstrate 0.00490.13141&radic&radic&radic S000005882GDS1YOR355WverifiedProtein of unknown function, required for growth on glycerol asa carbon source; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.004890.13141&radic&radic S000003011DST1YGL043WverifiedGeneral transcription elongation factor TFIIS, enables RNApolymerase II to read through blocks toelongation by stimulating cleavage of nascenttranscripts stalled at transcription arrestsites 0.004880.13122&radic S000005787RPN8YOR261CverifiedEssential, non-ATPase regulatory subunit of the 26S proteasome;has similarity to the human p40 proteasomalsubunit and to another S. cerevisiae regulatorysubunit, Rpn11p 0.004830.12939&radic S000005720TOA1YOR194CverifiedTFIIA large subunit; involved in transcriptional activation,acts as antirepressor or as coactivator;homologous to largest and second largestsubunits of human and Drosophila TFIIA 0.004850.12939&radic&radic S000004470SPT5YML010WverifiedProtein that forms a complex with Spt4p and mediates bothactivation and inhibition of transcriptionelongation; Spt4p-Spt5p complex also plays arole in pre-mRNA processing 0.004820.12939&radic&radic&radic S000002491TVP23YDR084CuncharacterizedIntegral membrane protein localized to late Golgi vesiclesalong with the v-SNARE Tlg2p; green fluorescentprotein (GFP)-fusion protein localizes to thecytoplasm in a punctate pattern 0.00480.12911&radic S000004636ARP9YMR033WverifiedActin-related protein involved in transcriptional regulation;subunit of the chromatin remodeling Snf/Swicomplex 0.004780.12855 S000005690YOR164CVerifiedProtein of unknown function; interacts with Mdy2p 0.004790.12855&radic&radic&radic S000000152PTC3YBL056WverifiedType 2C protein phosphatase; dephosphorylates Hog1p (see alsoPtc2p) to limit maximal kinase activity inducedby osmotic stress; dephosphorylates T169phosphorylated Cdc28p (see also Ptc2p); role inDNA checkpoint inactivation 0.004770.12744&radic&radic S000005732NOC2YOR206WverifiedProtein that forms a nucleolar complex with Mak21p that bindsto 90S and 66S pre-ribosomes, as well as anuclear complex with Noc3p that binds to 66Spre-ribosomes; both complexes mediateintranuclear transport of ribosomal precursors 0.004780.12744&radic&radic&radic S000005236PUS4YNL292WverifiedPseudouridine synthase, catalyzes only the formation ofpseudouridine-55 (Psi55), a highly conservedtRNA modification, in mitochondrial andcytoplasmic tRNAs; PUS4 overexpression leads totranslational derepression of GCN4 (Gcd-phenotype) 0.004750.12744&radic&radic&radic S000000729GIM4YEL003WverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.004780.12744&radic&radic&radic S000004296STT4YLR305CverifiedPhosphatidylinositol-4-kinase that functions in the Pkc1pprotein kinase pathway; required for normalvacuole morphology, cell wall integrity, andactin cytoskeleton organization 0.004720.12665 S000006186DIP5YPL265WverifiedDicarboxylic amino acid permease, mediates high-affinity andhigh-capacity transport of L-glutamate andL-aspartate; also a transporter for Gln, Asn,Ser, Ala, and Gly 0.004720.12665 S000001933RSC8YFR037CverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; essential for viability andmitotic growth; homolog of SWI/SNF subunitSwi3p, but unlike Swi3p, does not activatetranscription of reporters 0.004740.12665&radic S000000566MRC1YCL061CverifiedS-phase checkpoint protein found at replication forks, requiredfor DNA replication; also required for Rad53pactivation during DNA replication stress, whereit forms a replication-pausing complex withTof1p and is phosphorylated by Mec1p; proteininvolved in replication checkpoint 0.00470.12576&radic&radic&radic S000000638TAF2YCR042CverifiedTFIID subunit (150 kDa), involved in RNA polymerase IItranscription initiation 0.004680.12515 S000005735NPT1YOR209CverifiedNicotinate phosphoribosyltransferase, acts in the salvagepathway of NAD+ biosynthesis; required forsilencing at rDNA and telomeres and has a rolein silencing at mating-type loci; localized tothe nucleus 0.004680.12515&radic&radic&radic S000001695SAC1YKL212WverifiedLipid phosphoinositide phosphatase of the ER and Golgi,involved in protein trafficking and secretion 0.004690.12515&radic&radic&radic S000004365VID22YLR373CverifiedGlycosylated integral membrane protein localized to the plasmamembrane; plays a role infructose-1,6-bisphosphatase (FBPase)degradation; involved in FBPase transport fromthe cytosol to Vid (vacuole import anddegradation) vesicles 0.004630.12381&radic&radic S000005700MED4YOR174WverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation 0.004640.12381&radic&radic S000000781POL5YEL055CverifiedProtein with sequence similarity to the human MybBP1A and weaksequence similar to B-type DNA polymerases, notrequired for chromosomal DNA replication;required for the synthesis of rRNA 0.004650.12381&radic&radic&radic S000006111NAB3YPL190CverifiedSingle stranded DNA binding protein; acidic ribonucleoprotein;required for termination of non-poly(A)transcripts and efficient splicing; interactswith Nrd1p 0.004590.12251&radic&radic&radic S000000823RPN3YER021WverifiedEssential, non-ATPase regulatory subunit of the 26S proteasomelid, similar to the p58 subunit of the human26S proteasome; temperature-sensitive allelescause metaphase arrest, suggesting a role forthe proteasome in cell cycle control 0.004590.12251&radic&radic S000002968LSB3YFR024C-AverifiedProtein containing a C-terminal SH3 domain; binds Las17p, whichis a homolog of human Wiskott-Aldrich Syndromeprotein involved in actin patch assembly andactin polymerization 0.00460.12251&radic&radic&radic&radic S000004206CPR6YLR216CverifiedPeptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzesthe cis-trans isomerization of peptide bondsN-terminal to proline residues; binds to Hsp82pand contributes to chaperone activity 0.004590.12251&radic&radic S000002632HTB1YDR224CverifiedOne of two nearly identical (see HTB2) histone H2B subtypesrequired for chromatin assembly and chromosomefunction; Rad6p-Bre1p-Lge1p mediatedubiquitination regulates transcriptionalactivation, meiotic DSB formation and H3methylation 0.004550.12105&radic&radic&radic S000001564TEF4YKL081WverifiedTranslation elongation factor EF-1 gamma 0.004550.12105&radic&radic&radic S000005929CHL1YPL008WverifiedConserved nuclear protein required to establishsister-chromatid pairing during S-phase,probable DNA helicase with similarity to humanBACH1, which associates with tumor suppressorBRCA1; associates with acetyltransferase Ctf7p 0.004540.12063&radic&radic&radic S000001809SIR1YKR101WverifiedProtein involved in repression of transcription at the silentmating-type loci HML and HMR; recruitment tosilent chromatin requires interactions withOrc1p and with Sir4p, through a common Sir1pdomain; binds to centromeric chromatin 0.004540.12063 S000001578YJU2YKL095WverifiedEssential nuclear protein; putative spliceosomal componentinvolved in mRNA splicing, based oncomputational analysis of large-scaleprotein-protein interaction data 0.004540.12063&radic&radic S000003259RPS25AYGR027CverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps25Bp and has similarity to ratS25 ribosomal protein 0.004540.12063&radic&radic&radic S000000819AFG3YER017CverifiedComponent, with Yta12p, of the mitochondrial inner membranem-AAA protease that mediates degradation ofmisfolded or unassembled proteins and is alsorequired for correct assembly of mitochondrialenzyme complexes 0.004520.12004&radic&radic&radic S000000098HTB2YBL002WverifiedOne of two nearly identical (see HTB1) histone H2B subtypesrequired for chromatin assembly and chromosomefunction; Rad6p-Bre1p-Lge1p mediatedubiquitination regulates transcriptionalactivation, meiotic DSB formation and H3methylation 0.00450.11865&radic&radic S000001221STB5YHR178WverifiedActivator of multidrug resistance genes, forms a heterodimerwith Pdr1p; contains a Zn(II)2Cys6 zinc fingerdomain that interacts with a PDRE (pleotropicdrug resistance element) in vitro; binds Sin3pin a two-hybrid assay 0.004470.11865&radic&radic&radic&radic S000002630YDR222WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.004480.11865&radic&radic S000004929ELP6YMR312WverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;required for Elongator structural integrity 0.004490.11865 S000003861YJR100CUncharacterizedPutative protein of unknown function; appears related to murine NOR1, which is highly expressed in leukemogenic cell lines 0.004490.11865 S000006012GLR1YPL091WverifiedCytosolic and mitochondrial glutathione oxidoreductase,converts oxidized glutathione to reducedglutathione 0.004480.11865&radic&radic&radic&radic S000003496MES1YGR264CverifiedMethionyl-tRNA synthetase, forms a complex with glutamyl-tRNAsynthetase (Gus1p) and Arc1p, which increasesthe catalytic efficiency of both tRNAsynthetases; also has a role in nuclear exportof tRNAs 0.004470.11816&radic&radic S000001732DBP7YKR024CverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in ribosomal biogenesis 0.004450.11776&radic&radic S000005584ASE1YOR058CverifiedMember of a family of microtubule-associated proteins (MAPs)that function at the mitotic spindle midzone;required for spindle elongation; undergoes cellcycle-regulated degradation by anaphasepromoting complex; potential Cdc28p substrate 0.004430.11721&radic&radic&radic S000003466YHB1YGR234WverifiedNitric oxide oxidoreductase, flavohemoglobin involved in nitricoxide detoxification; plays a role in theoxidative and nitrosative stress responses 0.004430.11721&radic&radic S000000051PEX22YAL055WverifiedPutative peroxisomal membrane protein required for import ofperoxisomal proteins, functionally complementsa Pichia pastoris pex22 mutation 0.004410.11665&radic S000001555STB6YKL072WverifiedProtein that binds Sin3p in a two-hybrid assay 0.004420.11665&radic&radic S000001887BLM10YFL007WverifiedProteosome activator subunit; found in association with coreparticles, with and without the 19S regulatoryparticle; required for resistance to bleomycin,may be involved in protecting against oxidativedamage; similar to mammalian PA200 0.004410.11652&radic&radic&radic&radic S000005771DGA1YOR245CverifiedDiacylglycerol acyltransferase, catalyzes the terminal step oftriacylglycerol (TAG) formation, acylatesdiacylglycerol using acyl-CoA as an acyl donor,localized to lipid particles 0.00440.11643&radic S000005976LGE1YPL055CverifiedProtein of unknown function; null mutant forms abnormally largecells 0.00440.116&radic S000001608RRN3YKL125WverifiedProtein required for transcription of rDNA by RNA polymerase I;transcription factor independent of DNAtemplate; involved in recruitment of RNApolymerase I to rDNA 0.004390.116&radic&radic S000003371YGR139WDubiousHypothetical protein 0.004380.11546&radic&radic&radic S000005755WTM2YOR229WverifiedTranscriptional repressor involved in regulation of meiosis andsilencing; contains WD repeats 0.004350.11417&radic&radic S000003927ORC3YLL004WverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing 0.004340.11417&radic S000002728SWA2YDR320CverifiedAuxilin-like protein involved in vesicular transport;clathrin-binding protein required for uncoatingof clathrin-coated vesicles 0.004330.11313&radic S000000064SWD1YAR003WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres; WD40beta propeller superfamily member withsimilarity to mammalian Rbbp7 0.004310.11313 S000003412RNR4YGR180CverifiedRibonucleotide-diphosphate reductase (RNR), small subunit; theRNR complex catalyzes the rate-limiting step indNTP synthesis and is regulated by DNAreplication and DNA damage checkpoint pathwaysvia localization of the small subunits 0.004310.11313&radic&radic&radic S000004092APC9YLR102CverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 0.004290.11219&radic&radic&radic S000003660LSM1YJL124CverifiedLsm (Like Sm) protein; forms heteroheptameric complex (withLsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p)involved in degradation of cytoplasmic mRNAs 0.004280.11219&radic S000002776YPR1YDR368Wverified2-methylbutyraldehyde reductase, may be involved in isoleucinecatabolism 0.004290.11219&radic&radic&radic S000006366ORC4YPR162CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing 0.004290.11219&radic S000000435SWC5YBR231CuncharacterizedProtein of unknown function, component of the SWR1 complex,which exchanges histone variant H2AZ (Htz1p)for chromatin-bound histone H2A 0.004280.11219&radic S000005133SRP1YNL189WverifiedKaryopherin alpha homolog, forms a dimer with karyopherin betaKap95p to mediate import of nuclear proteins,binds the nuclear localization signal of thesubstrate during import; may also play a rolein regulation of protein degradation 0.004260.11127&radic&radic S000006119RPL7BYPL198WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl7Ap and has similarity to E.coli L30 and rat L7 ribosomal proteins;contains a conserved C-terminal Nucleic acidBinding Domain (NDB2) 0.004240.11105&radic&radic S000000813TIR1YER011WverifiedCell wall mannoprotein of the Srp1p/Tip1p family ofserine-alanine-rich proteins; expression isdownregulated at acidic pH and induced by coldshock and anaerobiosis; abundance is increasedin cells cultured without shaking 0.004250.11105&radic&radic&radic S000000787CIN8YEL061CverifiedKinesin motor protein involved in mitotic spindle assembly andchromosome segregation 0.004240.11091&radic&radic S000003163GCN1YGL195WverifiedPositive regulator of the Gcn2p kinase activity, forms acomplex with Gcn20p; proposed to stimulateGcn2p activation by an uncharged tRNA 0.004240.11091&radic S000000118PIM1YBL022CverifiedMitochondrial ATP-dependent protease involved inintramitochondrial proteolysis; involved indegradation of misfolded proteins inmitochondria; required for bigenesis andmaintenance of mitochondria 0.004230.11066&radic&radic&radic S000003842EAF6YJR082CuncharacterizedEsa1p-associated factor, subunit of the NuA4 acetyltransferasecomplex 0.004230.11066 S000001909IOC3YFR013WverifiedMember of a complex (Isw1a) with Isw1p that hasnucleosome-stimulated ATPase activity andrepresses transcription initiation by specificpositioning of a promoter proximaldinucleosome; has homology to Esc8p, which isinvolved in silencing 0.004220.11016&radic&radic&radic S000005711GSP2YOR185CverifiedGTP binding protein (mammalian Ranp homolog) involved in themaintenance of nuclear organization, RNAprocessing and transport; interacts withKap121p, Kap123p and Pdr6p (karyophilin betas);Gsp1p homolog that is not required forviability 0.004210.10971&radic&radic&radic&radic S000004494RAD52YML032CverifiedProtein that stimulates strand exchange by facilitating Rad51pbinding to single-stranded DNA; annealscomplementary single-stranded DNA; involved inthe repair of double-strand breaks in DNAduring vegetative growth and meiosis 0.004190.10936 S000002761TRR1YDR353WverifiedCytoplasmic thioredoxin reductase, key regulatory enzyme thatdetermines the redox state of the thioredoxinsystem, which acts as a disulfide reductasesystem and protects cells against bothoxidative and reductive stress 0.00420.10936&radic&radic&radic S000002837TIF35YDR429CverifiedSubunit of the core complex of translation initiation factor3(eIF3), which is essential for translation 0.004170.1088&radic&radic&radic S000002494RRP1YDR087CverifiedEssential evolutionarily conserved nucleolar protein necessaryfor biogenesis of 60S ribosomal subunits andprocessing of pre-rRNAs to mature rRNAs,associated with several distinct 66Spre-ribosomal particles 0.004160.1085&radic&radic S000003310PAC10YGR078CverifiedPart of the heteromeric co-chaperone GimC/prefoldin complex,which promotes efficient protein folding 0.004170.1085&radic&radic S000002598RVB1YDR190CverifiedEssential protein involved in transcription regulation;component of chromatin remodeling complexes;required for assembly and function of the INO80complex; member of the RUVB-like protein family 0.004150.10771&radic&radic&radic S000001346SDS3YIL084CverifiedComponent of the Rpd3p/Sin3p deacetylase complex required forits structural integrity and catalyticactivity, involved in transcriptional silencingand required for sporulation; cells defectivein SDS3 display pleiotropic phenotypes 0.004130.10767&radic S000005552BUB3YOR026WverifiedKinetochore checkpoint WD40 repeat protein that localizes tokinetochores during prophase and metaphase,delays anaphase in the presence of unattachedkinetochores; forms complexes with Mad1p-Bub1pand with Cdc20p, binds Mad2p and Mad3p 0.004120.10731&radic&radic&radic S000003718YJL182CDubiousHypothetical protein 0.004120.10731&radic&radic&radic S000006314RPC40YPR110CverifiedRNA polymerase subunit, common to RNA polymerase I and III 0.00410.10614&radic&radic S000004281YLR290CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR290C is not an essential gene 0.004090.10614&radic&radic S000000912KAP123YER110CverifiedKaryopherin beta, mediates nuclear import of ribosomal proteinsprior to assembly into ribosomes and import ofhistones H3 and H4; localizes to the nuclearpore, nucleus, and cytoplasm; exhibits geneticinteractions with RAI1 0.004090.10614&radic S000005688YRR1YOR162CverifiedZn2-Cys6 zinc-finger transcription factor that activates genesinvolved in multidrug resistance; paralog ofYrm1p, acting on an overlapping set of targetgenes 0.004090.10608&radic&radic&radic&radic S000003026RAD6YGL058WverifiedUbiquitin-conjugating enzyme (E2), involved in postreplicationrepair (with Rad18p), sporulation, telomeresilencing, and ubiquitin-mediated N-end ruleprotein degradation (with Ubr1p) 0.004080.10569&radic&radic S000004197HRD3YLR207WverifiedResident protein of the ER membrane that plays a central rolein ER-associated protein degradation (ERAD),forms HRD complex with Hrd1p and ERADdeterminants that engages in lumen to cytosolcommunication and coordination of ERAD events 0.004080.10569&radic&radic&radic S000004995YNL050CUncharacterizedPutative protein of unknown function; YNL050c is not an essential gene 0.004080.10569 S000004252YPT6YLR262CverifiedGTPase, Ras-like GTP binding protein involved in the secretorypathway, required for fusion ofendosome-derived vesicles with the late Golgi,maturation of the vacuolar carboxypeptidase Y;has similarity to the human GTPase, Rab6 0.004070.10507&radic S000006381YPR177CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex 0.004070.10507&radic S000004034PDC1YLR044CverifiedMajor of three pyruvate decarboxylase isozymes, key enzyme inalcoholic fermentation, decarboxylates pyruvateto acetaldehyde; subject to glucose-, ethanol-,and autoregulation; involved in amino acidcatabolism 0.004050.10489&radic&radic&radic S000005012FKH2YNL068CverifiedForkhead family transcription factor with a major role in theexpression of G2/M phase genes; positivelyregulates transcriptional elongation; negativerole in chromatin silencing at HML and HMR;substrate of the Cdc28p/Clb5p kinase 0.004040.10454 S000000818BIM1YER016WverifiedMicrotubule-binding protein that together with Kar9p makes upthe cortical microtubule capture site anddelays the exit from mitosis when the spindleis oriented abnormally 0.004030.10402&radic S000006373JIP5YPR169WuncharacterizedNucleolar protein of unknown function, exhibits a physicalinteraction with Bre1p 0.003990.10304&radic&radic S000004216BUR2YLR226WverifiedCyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2pcomprise a CDK-cyclin complex involved intranscriptional regulation through itsphosphorylation of the carboxy-terminal domainof the largest subunit of RNA polymerase II 0.003990.10304 S000001311DFG10YIL049WverifiedProtein of unknown function, involved in filamentous growth 0.003990.10219 S000000046GEM1YAL048CverifiedEvolutionarily-conserved tail-anchored outer mitochondrialmembrane GTPase which regulates mitochondrialmorphology; cells lacking Gem1p containcollapsed, globular, or grape-likemitochondria; not required forpheromone-induced cell death 0.003980.10219&radic S000003045HNM1YGL077CverifiedCholine transporter (permease) that also controls the uptake ofnitrogen mustard; expression is co-regulatedwith phospholipid biosynthetic genes andnegatively regulated by choline andmyo-inositol 0.003990.10219&radic&radic S000005952PHO85YPL031CverifiedCyclin-dependent kinase, with ten cyclin partners; involved inenvironmental stress response; inphosphate-rich conditions, Pho85p-Pho80pcomplex phosphorylates Pho4p which in turnrepresses PHO5 0.003980.10219&radic&radic&radic&radic S000002652PEX5YDR244WverifiedPeroxisomal membrane signal receptor for C-terminal tripeptidesignal sequence (PTS1) of peroxisomal matrixproteins, required for peroxisomal matrixprotein import, tetratricopeptide repeatprotein, also involved in PTS1-independentimport 0.003990.10219&radic S000004081YLR091WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR091W is not an esssential gene 0.003950.10036&radic&radic&radic S000005080EAF7YNL136WverifiedSubunit of the NuA4 histone acetyltransferase complex, whichacetylates the N-terminal tails of histones H4and H2A 0.003950.10036 S000001072SLT2YHR030CverifiedSerine/threonine MAP kinase involved in regulating themaintenance of cell wall integrity andprogression through the cell cycle; regulatedby the PKC1-mediated signaling pathway 0.003930.10036&radic&radic&radic S000005246RPS19BYNL302CverifiedProtein component of the small (40S) ribosomal subunit,required for assembly and maturation of pre-40S particles; mutations in human RPS19 areassociated with Diamond Blackfan anemia; nearlyidentical to Rps19Ap 0.003920.10036&radic&radic&radic S000003237TFG2YGR005CverifiedTFIIF (Transcription Factor II) middle subunit; involved inboth transcription initiation and elongation ofRNA polymerase II; homologous to human RAP30 0.003950.10036&radic S000000776RML2YEL050CverifiedMitochondrial ribosomal protein of the large subunit, hassimilarity to E. coli L2 ribosomal protein;fat21 mutant allele causes inability to utilizeoleate and may interfere with activity of theAdr1p transcription factor 0.003940.10036&radic&radic&radic S000000867ICL1YER065CverifiedIsocitrate lyase, catalyzes the formation of succinate andglyoxylate from isocitrate, a key reaction ofthe glyoxylate cycle; expression of ICL1 isinduced by growth on ethanol and repressed bygrowth on glucose 0.003950.10036&radic S000000146SEC17YBL050WverifiedPeripheral membrane protein required for vesicular transportbetween ER and Golgi and for the 'priming' stepin homotypic vacuole fusion, part of thecis-SNARE complex; has similarity to alpha-SNAP 0.003940.10036&radic S000004264CDC46YLR274WverifiedComponent of the hexameric MCM complex, which is important forpriming origins of DNA replication in G1 andbecomes an active ATP-dependent helicase thatpromotes DNA melting and elongation whenactivated by Cdc7p-Dbf4p in S-phase 0.003950.10036&radic&radic S000000539LSB5YCL034WverifiedProtein of unknown function; binds Las17p, which is a homologof human Wiskott-Aldrich Syndrome proteininvolved in actin patch assembly and actinpolymerization 0.003920.09928&radic&radic&radic S000005242CLA4YNL298WverifiedCdc42p activated signal transducing kinase of the PAK(p21-activated kinase) family, involved inseptin ring assembly and cytokinesis; directlyphosphorylates septins Cdc3p and Cdc10p; otheryeast PAK family members are Ste20p and Skm1p 0.00390.09928&radic&radic S000000851TPA1YER049WuncharacterizedProtein of unknown function; interacts with Sup45p (eRF1),Sup35p (eRF3) and Pab1p; has a role intranslation termination efficiency, mRNApoly(A) tail length and mRNA stability 0.00390.09928&radic&radic&radic S000005524BDS1YOL164WverifiedBacterially-derived sulfatase required for use of alkyl- andaryl-sulfates as sulfur sources 0.00390.09928 S000005505CTR9YOL145CverifiedComponent of the Paf1p complex, which is a large complex thatbinds to and modulates the activity of RNApolymerase II and is required for expression ofa subset of genes, including cyclin genes;contains TPR repeats 0.003910.09928 S000004135RMP1YLR145WverifiedEssential component of RNase MRP, which processes pre-rRNA inthe nucleolus and also processes mitochondrialRNAs to create RNA primers for DNA replication 0.00390.09928&radic&radic&radic S000004329VRP1YLR337CverifiedProline-rich actin-associated protein involved in cytoskeletalorganization and cytokinesis; related tomammalian Wiskott-Aldrich syndrome protein(WASP)-interacting protein (WIP) 0.003880.09869&radic&radic S000005568CUE5YOR042WuncharacterizedProtein containing a CUE domain that binds ubiquitin, which mayfacilitate intramolecular monoubiquitination;green fluorescent protein (GFP)-fusion proteinlocalizes to the cytoplasm in a punctatepattern 0.003890.09869&radic&radic&radic S000004926NIP1YMR309CverifiedSubunit of the eukaryotic translation initiation factor 3(eIF3), involved in the assembly ofpreinitiation complex and start codon selection 0.003870.09836&radic&radic S000005659EFT1YOR133WverifiedElongation factor 2 (EF-2), also encoded by EFT2; catalyzesribosomal translocation during proteinsynthesis; contains diphthamide, the uniqueposttranslationally modified histidine residuespecifically ADP-ribosylated by diphtheriatoxin 0.003870.09836&radic&radic&radic S000000379SWD3YBR175WverifiedEssential subunit of the COMPASS (Set1C) complex, whichmethylates histone H3 on lysine 4 and isrequired in transcriptional silencing neartelomeres; WD40 beta propeller superfamilymember and ortholog of mammalian WDR5 0.003870.09836&radic&radic S000003225ADH4YGL256WverifiedAlcohol dehydrogenase type IV, dimeric enzyme demonstrated tobe zinc-dependent despite sequence similarityto iron-activated alcohol dehydrogenases;transcription is induced in response to zincdeficiency; alcohol dehydrogenase isoenzyme IV 0.003870.09836&radic&radic S000002674YDR266CUncharacterizedHypothetical protein 0.003870.09836&radic&radic&radic&radic S000004070EMP46YLR080WverifiedIntegral membrane component of endoplasmic reticulum-derivedCOPII-coated vesicles, which function in ER toGolgi transport 0.003840.09707&radic&radic S000006312RPN7YPR108WverifiedEssential, non-ATPase regulatory subunit of the 26S proteasome,similar to another S. cerevisiae regulatorysubunit, Rpn5p, as well as to mammalianproteasome subunits 0.003840.09707&radic S000001220YHR177WUncharacterized 0.003860.09707&radic&radic&radic S000004099AHP1YLR109WverifiedThiol-specific peroxiredoxin, reduces hydroperoxides to protectagainst oxidative damage; function in vivorequires covalent conjugation to Urm1p 0.003860.09707&radic&radic&radic S000005419ARG1YOL058WverifiedArginosuccinate synthetase, catalyzes the formation ofL-argininosuccinate from citrulline andL-aspartate in the arginine biosynthesispathway; potential Cdc28p substrate 0.003860.09707&radic&radic S000002573SEC5YDR166CverifiedEssential 107kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which has the essential function ofmediating polarized targeting of secretoryvesicles to active sites of exocytosis 0.003840.09707&radic&radic S000005785RPT4YOR259CverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; required for spindlepole body duplication; localized mainly to thenucleus throughout the cell cycle 0.003830.09671 S000004225YLR235CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TOP3 0.003830.09671&radic&radic S000001596RAD27YKL113Cverified5' to 3' exonuclease, 5' flap endonuclease, required forOkazaki fragment processing and maturation aswell as for long-patch base-excision repair;member of the S. pombe RAD2/FEN1 family 0.003810.09624 S000002773ESF1YDR365CverifiedNucleolar protein involved in pre-rRNA processing; depletioncauses severely decreased 18S rRNA levels 0.003820.09624&radic&radic S000001222OYE2YHR179WverifiedWidely conserved NADPH oxidoreductase containing flavinmononucleotide (FMN), homologous to Oye3p withslight differences in ligand binding andcatalytic properties; may be involved in sterolmetabolism 0.003810.09599&radic&radic S000000602RVS161YCR009CverifiedAmphiphysin-like lipid raft protein; subunit of a complex(Rvs161p-Rvs167p) that regulates polarizationof the actin cytoskeleton, endocytosis, cellpolarity, cell fusion and viability followingstarvation or osmotic stress 0.003790.09542&radic&radic S000005842SFG1YOR315WverifiedNuclear protein, putative transcription factor required forgrowth of superficial pseudohyphae (which donot invade the agar substrate) but not forinvasive pseudohyphal growth; may act togetherwith Phd1p; potential Cdc28p substrate 0.003790.09542&radic&radic S000004841MTF1YMR228WverifiedMitochondrial RNA polymerase specificity factor with structuralsimilarity to S-adenosylmethionine-dependentmethyltransferases and functional similarity tobacterial sigma-factors, interacts withmitochondrial core polymerase Rpo41p 0.003790.0954&radic&radic S000001550YNK1YKL067WverifiedNucleoside diphosphate kinase, catalyzes the transfer of gammaphosphates from nucleoside triphosphates,usually ATP, to nucleoside diphosphates by amechanism that involves formation of anautophosphorylated enzyme intermediate 0.003780.09479&radic&radic&radic S000006315DBF20YPR111WverifiedSer/Thr kinase involved in late nuclear division, one of themitotic exit network (MEN) proteins; necessaryfor the execution of cytokinesis 0.003780.09479&radic&radic&radic S000006074RAD53YPL153CverifiedProtein kinase, required for cell-cycle arrest in response toDNA damage; activated by transautophosphorylation when interacting withhyperphosphorylated Rad9p; also interacts withARS1 and plays a role in initiation of DNAreplication 0.003780.09479&radic S000000521DCC1YCL016CverifiedSubunit of a complex with Ctf8p and Ctf18p that shares somecomponents with Replication Factor C, requiredfor sister chromatid cohesion and telomerelength maintenance 0.003780.09479 S000002228BDF2YDL070WverifiedProtein involved in transcription initiation at TATA-containingpromoters; associates with the basaltranscription factor TFIID; contains twobromodomains; corresponds to the C-terminalregion of mammalian TAF1; redundant with Bdf1p 0.003740.09384&radic S000004847RNH1YMR234WverifiedRibonuclease H1, removes RNA primers during Okazaki fragmentsynthesis; degrades RNA attached to the 5'-endof a DNA strand 0.003750.09384&radic&radic&radic&radic S000004873TIF11YMR260CverifiedTranslation initiation factor eIF1A, essential protein thatforms a complex with Sui1p (eIF1) and the 40Sribosomal subunit and scans for the startcodon; C-terminus associates with Fun12p(eIF5B); N terminus interacts with eIF2 andeIF3 0.003730.09349&radic S000004868GFD1YMR255WverifiedCoiled-coiled protein of unknown function, identified as ahigh-copy suppressor of a dbp5 mutation 0.003730.09349&radic&radic&radic&radic S000003463PHB2YGR231CverifiedSubunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDaring-shaped inner mitochondrial membranechaperone that stabilizes newly synthesizedproteins; determinant of replicative life span;involved in mitochondrial segregation 0.003730.09314 S000005879YOR352WUncharacterizedHypothetical protein 0.003730.09314&radic&radic&radic S000001474YIR035CUncharacterizedHypothetical protein 0.003710.09265&radic&radic&radic S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling 0.003710.09218&radic&radic&radic S000004903HAS1YMR290CverifiedATP-dependent RNA helicase; localizes to both the nuclearperiphery and nucleolus; highly enriched innuclear pore complex fractions; constituent of66S pre-ribosomal particles 0.003710.09218&radic S000007587KTI11YBL071W-AverifiedProtein required for synthesis of diphthamide, a modifiedhistidine residue of translation elongationfactor 2; functions with Dph1p, Dph2p, Jjj3p,and Dph5p; required, with Elongator complex,for modification of wobble nucleosides in tRNA 0.00370.09218&radic S000002510STE5YDR103WverifiedPheromone-responsive scaffold protein; shuttles from thenucleus to the plasma membrane and assembleskinases Ste11p, Ste7p, and Fus3p into aspecific signaling complex; active oligomericform interacts with Ste4p-Ste18p complex 0.003690.09176&radic&radic&radic S000004283SEC72YLR292CverifiedNon-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66pand Sec72p); with Sec61 complex, Kar2p/BiP andLhs1p forms a channel competent forSRP-dependent and post-translationalSRP-independent protein targeting and importinto the ER 0.003690.09176&radic S000002844PPZ2YDR436WverifiedSerine/threonine protein phosphatase Z, isoform of Ppz1p;involved in regulation of potassium transport,which affects osmotic stability, cell cycleprogression, and halotolerance 0.003670.09089&radic&radic S000002406MPH2YDL247WverifiedAlpha-glucoside permease, transports maltose, maltotriose,alpha-methylglucoside, and turanose; identicalto Mph3p; encoded in a subtelomeric position ina region likely to have undergone duplication 0.003660.09089 S000004641CCS1YMR038CverifiedCopper chaperone for superoxide dismutase Sod1p, involved inoxidative stress protection; Met-X-Cys-X2-Cysmotif within the N-terminal portion is involvedin insertion of copper into Sod1p underconditions of copper deprivation 0.003630.0896&radic&radic&radic&radic S000006099CBC2YPL178WverifiedSmall subunit of the heterodimeric cap binding complex thatalso contains Sto1p, component of thespliceosomal commitment complex; interacts withNpl3p, possibly to package mRNA for export fromthe nucleus; contains an RNA-binding motif 0.003630.0896&radic&radic S000003921MPH3YJR160CverifiedAlpha-glucoside permease, transports maltose, maltotriose,alpha-methylglucoside, and turanose; identicalto Mph2p; encoded in a subtelomeric position ina region likely to have undergone duplication 0.003630.0896 S000005902GDH1YOR375CverifiedNADP(+)-dependent glutamate dehydrogenase, synthesizesglutamate from ammonia and alpha-ketoglutarate;rate of alpha-ketoglutarate utilization differsfrom Gdh3p; expression regulated by nitrogenand carbon sources 0.003630.0896&radic&radic&radic&radic S000000816HEM14YER014WverifiedProtoporphyrinogen oxidase, a mitochondrial enzyme thatcatalyzes the seventh step in the hemebiosynthetic pathway, convertingprotoporphyrinogen IX to protoporphyrin IX 0.003650.0896&radic&radic S000002648SNU56YDR240CverifiedComponent of U1 snRNP required for mRNA splicing viaspliceosome; yeast specific, no metazoancounterpart; interacts with mRNA in commitmentcomplex 0.003620.0896&radic&radic S000002857UTP6YDR449CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.003650.0896 S000001897LOC1YFR001WverifiedNuclear protein involved in asymmetric localization of ASH1mRNA; binds double-stranded RNA in vitro;constituent of 66S pre-ribosomal particles 0.003650.0896&radic&radic S000002793EFT2YDR385WverifiedElongation factor 2 (EF-2), also encoded by EFT1; catalyzesribosomal translocation during proteinsynthesis; contains diphthamide, the uniqueposttranslationally modified histidine residuespecifically ADP-ribosylated by diphtheriatoxin 0.003630.0896&radic&radic S000003494BUD32YGR262CverifiedProtein kinase proposed to be involved in bud-site selection,telomere uncapping and elongation, andtranscription; component of the EKC/KEOPSprotein complex with Kae1p, Cgi121p, Pcc1p, andGon7p 0.003610.08925&radic&radic&radic&radic S000004018ADE16YLR028CverifiedEnzyme of 'de novo' purine biosynthesis containing both5-aminoimidazole-4-carboxamide ribonucleotidetransformylase and inosine monophosphatecyclohydrolase activities, isozyme of Ade17p;ade16 ade17 mutants require adenine andhistidine 0.003610.08915&radic&radic&radic&radic S000004824DML1YMR211WverifiedEssential protein involved in mtDNA inheritance, may alsofunction in the partitioning of themitochondrial organelle or in the segregationof chromosomes, exhibits regions similar tomembers of a GTPase family 0.003610.08915&radic&radic S000001159TOM71YHR117WverifiedMitochondrial outer membrane protein with similarity to Tom70p;probable minor component of the TOM(translocase of outer membrane) complexresponsible for recognition and import ofmitochondrially directed proteins 0.003610.08915 S000003013RIM8YGL045WverifiedProtein of unknown function, involved in the proteolyticactivation of Rim101p in response to alkalinepH; has similarity to A. nidulans PalF 0.003610.08866&radic&radic&radic S000000510PGS1YCL004WverifiedPhosphatidylglycerolphosphate synthase, catalyzes the synthesisof phosphatidylglycerolphosphate fromCDP-diacylglycerol and sn-glycerol 3-phosphatein the first committed and rate-limiting stepof cardiolipin biosynthesis 0.00360.08866&radic&radic&radic S000001857TUB2YFL037WverifiedBeta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p)to form tubulin dimer, which polymerizes toform microtubules 0.003590.08791&radic&radic S000002993PGD1YGL025CverifiedSubunit of the Mediator global transcriptional cofactorcomplex, which is part of the RNA polymerase IIholoenzyme and plays an essential role in basaland activated transcription; direct target ofthe Cyc8p-Tup1p transcriptional corepressor 0.003580.08791 S000005215BNI1YNL271CverifiedFormin, nucleates the formation of linear actin filaments,involved in cell processes such as budding andmitotic spindle orientation which require theformation of polarized actin cables,functionally redundant with BNR1 0.003580.08791&radic&radic S000004190YKE2YLR200WverifiedSubunit of the heterohexameric Gim/prefoldin protein complexinvolved in the folding of alpha-tubulin,beta-tubulin, and actin 0.003590.08791&radic&radic S000005775APC5YOR249CverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 0.003590.08791 S000004265SMD2YLR275WverifiedCore Sm protein Sm D2; part of heteroheptameric complex (withSmb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D2 0.003580.08791&radic&radic S000006061MKK2YPL140CverifiedMitogen-activated kinase kinase involved in protein kinase Csignaling pathway that controls cell integrity;upon activation by Bck1p phosphorylatesdownstream target, Slt2p; functionallyredundant with Mkk1p 0.003580.0878&radic&radic&radic S000000815PRP22YER013WverifiedDEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase,associates with lariat intermediates before thesecond catalytic step of splicing; mediatesATP-dependent mRNA release from the spliceosomeand unwinds RNA duplexes 0.003570.08749&radic&radic&radic S000006339CTF4YPR135WverifiedChromatin-associated protein, required for sister chromatidcohesion; interacts with DNA polymerase alpha(Pol1p) and may link DNA synthesis to sisterchromatid cohesion 0.003570.08749 S000001873GAT1YFL021WverifiedTranscriptional activator of genes involved in nitrogencatabolite repression, member of the GATAfamily of DNA binding proteins; activity andlocalization regulated by nitrogen limitationand Ure2p 0.003550.08664&radic&radic&radic&radic S000005420GPD2YOL059WverifiedNAD-dependent glycerol 3-phosphate dehydrogenase, homolog ofGpd1p, expression is controlled by anoxygen-independent signaling pathway requiredto regulate metabolism under anoxic conditions;located in cytosol and mitochondria 0.003550.08664&radic&radic S000000886YER084WDubiousHypothetical protein 0.003550.08664&radic&radic&radic&radic S000000440ABD1YBR236CverifiedMethyltransferase, catalyzes the transfer of a methyl groupfrom S-adenosylmethionine to the GpppN terminusof capped mRNA 0.003550.08664&radic S000005859VMA4YOR332WverifiedSubunit E of the eight-subunit V1 peripheral membrane domain ofthe vacuolar H+-ATPase (V-ATPase), anelectrogenic proton pump found throughout theendomembrane system; required for the V1 domainto assemble onto the vacuolar membrane 0.003540.08644&radic S000001545MSN4YKL062WverifiedTranscriptional activator related to Msn2p; activated in stressconditions, which results in translocation fromthe cytoplasm to the nucleus; binds DNA atstress response elements of responsive genes,inducing gene expression 0.003530.08608&radic&radic S000003621EXO70YJL085WverifiedEssential 70kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which has the essential function ofmediating polarized targeting of secretoryvesicles to active sites of exocytosis 0.003530.08608&radic S000004093CDC45YLR103CverifiedDNA replication initiation factor; recruited to MCM pre-RCcomplexes at replication origins; promotesrelease of MCM from Mcm10p, recruits elongationmachinery; mutants in human homolog may causevelocardiofacial and DiGeorge syndromes 0.003530.08608 S000003038RPB9YGL070CverifiedRNA polymerase II subunit B12.6; contacts DNA; mutations affecttranscription start site; involved in telomeremaintenance 0.003530.08605&radic S000005418YOL057WUncharacterizedPutative metalloprotease 0.003520.08584&radic&radic&radic&radic S000005857MIP1YOR330CverifiedCatalytic subunit of the mitochondrial DNA polymerase;conserved C-terminal segment is required forthe maintenance of mitochondrial genome. 0.003510.08537&radic&radic S000001899YPI1YFR003CverifiedInhibitor of the type I protein phosphatase Glc7p, which isinvolved in regulation of a variety ofmetabolic processes; overproduction causesdecreased cellular content of glycogen 0.003510.08537&radic S000005723MCA1YOR197WverifiedPutative cysteine protease similar to mammalian caspases,involved in regulation of apoptosis uponhydrogen peroxide treatment 0.003510.08537&radic&radic S000001210THP2YHR167WverifiedSubunit of the THO complex, which connects transcriptionelongation and mitotic recombination, and ofthe TREX complex, which is recruited toactivated genes and couples transcription tomRNA export; involved in telomere maintenance 0.003510.08537&radic&radic&radic&radic S000000889YER087WUncharacterizedHypothetical protein 0.003510.08537&radic S000004893CAT8YMR280CverifiedZinc cluster transcriptional activator necessary forderepression of a variety of genes undernon-fermentative growth conditions, activeafter diauxic shift, binds carbon sourceresponsive elements 0.003510.08537&radic&radic&radic&radic S000003665TRK1YJL129CverifiedComponent of the Trk1p-Trk2p potassium transport system; 180kDa high affinity potassium transporter;phosphorylated in vivo and interacts physicallywith the phosphatase Ppz1p, suggesting Trk1pacitivy is regulated by phosphorylation 0.00350.08494&radic&radic S000000060YAL064WUncharacterizedHypothetical protein 0.00350.08494 S000003719MNN11YJL183WverifiedSubunit of a Golgi mannosyltransferase complex that alsocontains Anp1p, Mnn9p, Mnn10p, and Hoc1p, andmediates elongation of the polysaccharidemannan backbone; has homology to Mnn10p 0.00350.08494&radic&radic S000003682IDS2YJL146WverifiedProtein involved in modulation of Ime2p activity duringmeiosis, appears to act indirectly to promoteIme2p-mediated late meiotic functions; found ingrowing cells and degraded during sporulation 0.003490.08491&radic&radic&radic S000000832CHZ1YER030WuncharacterizedPutative chaperone for Htz1p/H2A-H2B dimer 0.003490.08441&radic&radic&radic S000005985CWC27YPL064CverifiedComponent of a complex containing Cef1p, putatively involved inpre-mRNA splicing; has similarity to S. pombeCwf27p 0.003490.08441&radic&radic&radic S000001693UBA1YKL210WverifiedUbiquitin activating enzyme, involved in ubiquitin-mediatedprotein degradation and essential for viability 0.003480.08441&radic&radic&radic&radic S000002708PRO1YDR300CverifiedGamma-glutamyl kinase, catalyzes the first step in prolinebiosynthesis 0.003480.08441&radic&radic S000003313SLX9YGR081CverifiedProtein of unknown function; deletion mutant has syntheticfitness defect with an sgs1 deletion mutant 0.003470.08415&radic&radic&radic S000004140STM1YLR150WverifiedProtein that binds G4 quadruplex and purine motif triplexnucleic acid; acts with Cdc13p to maintaintelomere structure; interacts with ribosomesand subtelomeric Y' DNA; multicopy suppressorof tom1 and pop2 mutations 0.003440.08279&radic&radic S000004388VPS33YLR396CverifiedATP-binding protein that is a subunit of the homotypic vacuolefusion and vacuole protein sorting (HOPS)complex; essential for membrane docking andfusion at both the Golgi-to-endosome andendosome-to-vacuole stages of protein transport 0.003470.08279&radic S000005399RPP2AYOL039WverifiedRibosomal protein P2 alpha, a component of the ribosomal stalk,which is involved in the interaction betweentranslational elongation factors and theribosome; regulates the accumulation of P1(Rpp1Ap and Rpp1Bp) in the cytoplasm 0.003440.08279&radic&radic&radic S000000605PGK1YCR012Wverified3-phosphoglycerate kinase, catalyzes transfer of high-energyphosphoryl groups from the acyl phosphate of1,3-bisphosphoglycerate to ADP to produce ATP;key enzyme in glycolysis and gluconeogenesis 0.003460.08279&radic S000005556DFG16YOR030WverifiedProbable multiple transmembrane protein, involved in diploidinvasive and pseudohyphal growth upon nitrogenstarvation; required for accumulation ofprocessed Rim101p 0.003450.08279&radic&radic&radic S000003320CTT1YGR088WverifiedCytosolic catalase T, has a role in protection from oxidativedamage by hydrogen peroxide 0.003450.08279&radic&radic&radic&radic S000004665RNA14YMR061WverifiedCleavage and polyadenylation factor I (CF I) component involvedin cleavage and polyadenylation of mRNA 3'ends; bridges interaction between Rna15p andHrp1p in the CF I complex 0.003440.08279 S000002537FIN1YDR130CverifiedSpindle pole body-related intermediate filament protein, formscell cycle-specific filaments between spindlepole bodies in mother and daughter cells, ableto self-assemble, expression induced duringS/G2, localization cell-cycle dependent 0.003450.08279&radic&radic S000001574YKL091CVerifiedPutative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus 0.003470.08279&radic&radic&radic S000002621UPC2YDR213WverifiedSterol regulatory element binding protein, inducestranscription of sterol transport andbiosynthetic genes; involved in the anaerobicinduction of DAN/TIR mannoproteins andseripauperins; binucleate zinc cluster protein;Ecm22p homolog 0.003450.08279&radic&radic S000000081SWH1YAR042WverifiedProtein similar to mammalian oxysterol-binding protein;contains ankyrin repeats; localizes to theGolgi and the nucleus-vacuole junction 0.003460.08279 S000004628PEX12YMR026CverifiedRING-finger peroxisomal membrane peroxin that plays anessential role in peroxisome biogenesis andperoxisomal matrix protein import, formstranslocation subcomplex with Pex2p and Pex10p 0.003470.08279&radic S000000552YCL047CUncharacterizedPutative protein of unknown function 0.003460.08279&radic S000001667SPE1YKL184WverifiedOrnithine decarboxylase, catalyzes the first step in polyaminebiosynthesis; degraded in aproteasome-dependent manner in the presence ofexcess polyamines 0.003450.08279&radic S000004896RIT1YMR283Cverified2'-O-ribosyl phosphate transferase, modifies the initiatormethionine tRNA at position 64 to distinguishit from elongator methionine tRNA 0.003460.08279&radic&radic&radic&radic S000001860YFL034WUncharacterizedPutative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk 0.003450.08279&radic S000005937SWI1YPL016WverifiedSubunit of the SWI/SNF chromatin remodeling complex, whichregulates transcription by remodelingchromosomes; required for transcription of manygenes, including ADH1, ADH2, GAL1, HO, INO1 andSUC2 0.003430.08256&radic S000000661HCM1YCR065WverifiedForkhead transcription factor that drives S-phase specificexpression of genes involved in chromosomesegregation, spindle dynamics, and budding;suppressor of calmodulin mutants with specificSPB assembly defects; telomere maintenance role 0.003430.08256&radic S000005251MCK1YNL307CverifiedProtein serine/threonine/tyrosine (dual-specificity) kinaseinvolved in control of chromosome segregationand in regulating entry into meiosis; relatedto mammalian glycogen synthase kinases of theGSK-3 family 0.003420.0822&radic&radic&radic&radic S000003325YGR093WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus 0.003430.0822 S000004137SMD3YLR147CverifiedCore Sm protein Sm D3; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D3 0.003420.0822&radic&radic&radic S000002673PEX10YDR265WverifiedRING finger peroxisomal membrane peroxin required forperoxisomal matrix protein import, interactswith Pex12p, links ubiquitin-conjugating Pex4pto protein import machinery; mutations in humanhomolog cause a variety of peroxisomaldisorders 0.003420.0822&radic&radic S000003212TAD1YGL243WverifiedtRNA-specific adenosine deaminase, deaminates adenosine-37 toinosine in tRNA-Ala 0.003420.08177&radic&radic&radic&radic S000005603RTS2YOR077WverifiedBasic zinc-finger protein, similar to human and mouse Kin17proteins which are chromatin-associatedproteins involved in UV response and DNAreplication 0.003410.08177&radic&radic&radic S000003279TFC4YGR047CverifiedOne of six subunits of the RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part of theTauA domain of TFIIIC that binds BoxA DNApromoter sites of tRNA and similar genes; hasTPR motifs; human homolog is TFIIIC-102 0.00340.08136&radic&radic&radic S000001226GND1YHR183Wverified6-phosphogluconate dehydrogenase (decarboxylating), catalyzesan NADPH regenerating reaction in the pentosephosphate pathway; required for growth onD-glucono-delta-lactone and adaptation tooxidative stress 0.00340.08136&radic&radic&radic S000005065TOM70YNL121CverifiedComponent of the TOM (translocase of outer membrane) complexresponsible for recognition and initial importsteps for all mitochondrially directedproteins; acts as a receptor for incomingprecursor proteins 0.003390.08136 S000006331YPR127WUncharacterizedHypothetical protein 0.00340.08136&radic&radic&radic&radic S000004843RPS10BYMR230WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps10Ap and has similarity to ratribosomal protein S10 0.00340.08136&radic S000002637IVY1YDR229WverifiedPhospholipid-binding protein that interacts with both Ypt7p andVps33p, may partially counteract the action ofVps33p and vice versa, localizes to the rim ofthe vacuole as cells approach stationary phase 0.003390.08113&radic&radic S000000601SAT4YCR008WverifiedSer/Thr protein kinase involved in salt tolerance; funtions inregulation of Trk1p-Trk2p potassiumtransporter; partially redundant with Hal5p;has similarity to Npr1p 0.003390.08113&radic&radic&radic S000001334HOP1YIL072WverifiedMeiosis-specific DNA binding protein that displays Red1pdependent localization to the unsynapsedaxial-lateral elements of the synaptonemalcomplex; required for homologous chromosomesynapsis and chiasma formation 0.003390.08113&radic&radic&radic S000005226POP3YNL282WverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends 0.003380.08073&radic&radic&radic S000004835FSH2YMR222CverifiedSerine hydrolase that localizes to the cytoplasm; sequence issimilar to Fsh1p and Fsh3p 0.003380.08073&radic&radic&radic S000003367PRE9YGR135Wverified20S proteasome beta-type subunit; the only nonessential 20Ssubunit 0.003380.08073&radic S000004181PEX13YLR191WverifiedIntegral peroxisomal membrane receptor for the PTS1 peroxisomalmatrix protein signal recognition factor Pex5p,required for the translocation of peroxisomalmatrix proteins, also interacts with Pex7p andPex14p, contains a C-terminal SH3 domain 0.003370.08071&radic S000004224TOP3YLR234WverifiedDNA Topoisomerase III, conserved protein that functions in acomplex with Sgs1p and Rmi1p to relaxsingle-stranded negatively-supercoiled DNApreferentially, involved in telomere stabilityand regulation of mitotic recombination 0.003370.08052&radic&radic&radic S000003050YGL082WUncharacterizedHypothetical protein 0.003350.07983&radic&radic&radic S000003118INO80YGL150CverifiedATPase that forms a large complex, containing actin and severalactin-related proteins, that has chromatinremodeling activity and 3' to 5' DNA helicaseactivity in vitro; shows similarity to theSnf2p family of ATPases 0.003350.07983 S000005561SHE4YOR035CverifiedProtein containing a UCS (UNC-45/CRO1/SHE4) domain, binds tomyosin motor domains to regulate myosinfunction; involved in endocytosis, polarizationof the actin cytoskeleton, and asymmetric mRNAlocalization 0.003350.07983&radic&radic&radic&radic S000001618APL2YKL135CverifiedBeta-adaptin, large subunit of the clathrin-associated protein(AP-1) complex; binds clathrin; involved inclathrin-dependent Golgi protein sorting 0.003350.07983&radic&radic&radic S000001234CTF8YHR191CverifiedSubunit of a complex with Ctf18p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion 0.003340.07959 S000005713TUF1YOR187WverifiedMitochondrial translation elongation factor Tu; comprises bothGTPase and guanine nucleotide exchange factoractivities, while these activities are found inseparate proteins in S. pombe and humans 0.003340.07959&radic&radic&radic S000005387MDM38YOL027CverifiedMitochondrial inner membrane protein, required for K+/H+exchange and for normal mitochondrialmorphology and inheritance; associates withmitochondrial ribosomes; human ortholog Letm1is implicated in Wolf-Hirschhorn syndrome 0.003320.0786&radic&radic&radic S000000476HSM3YBR272CverifiedProtein of unknown function, involved in DNA mismatch repairduring slow growth; has weak similarity toMsh1p 0.003320.0786&radic S000004789MMT1YMR177WverifiedPutative metal transporter involved in mitochondrial ironaccumulation; closely related to Mmt2p 0.003320.0786 S000002948IRC4YDR540CuncharacterizedHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 0.003330.0786&radic&radic&radic S000003242NMA2YGR010WverifiedNicotinic acid mononucleotide adenylyltransferase, involved inNAD(+) salvage pathway 0.003310.0786&radic&radic&radic S000005979PDR12YPL058CverifiedPlasma membrane weak-acid-inducible ATP-binding cassette (ABC)transporter, required for weak organic acidresistance, strongly induced by sorbate andbenzoate, regulated by War1p, mutants exhibitsorbate hypersensitivity 0.003320.0786&radic&radic&radic S000004642SUB1YMR039CverifiedTranscriptional coactivator, facilitates elongation byinfluencing enzymes that modify RNAP II, actsin a peroxide resistance pathway involvingRad2p; suppressor of TFIIB mutations 0.003340.0786&radic&radic S000007230YCR018C-ADubiousPutative protein of unknown function; encoded opposite a Ty1 LTR 0.003320.0786&radic S000004410CDC73YLR418CverifiedConstituent of Paf1 complex with RNA polymerase II, Paf1p,Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinctfrom Srb-containing Pol II complexes; requiredfor expression of certain genes, modificationof some histones, and telomere maintenance 0.003320.0786 S000004210CCC1YLR220WverifiedPutative vacuolar Fe2+/Mn2+ transporter; suppresses respiratorydeficit of yfh1 mutants, which lack theortholog of mammalian frataxin, by preventingmitochondrial iron accumulation 0.003330.0786&radic&radic&radic S000001082BCD1YHR040WverifiedEssential protein required for the accumulation of box C/DsnoRNA 0.003310.0786&radic&radic&radic S000000461POP4YBR257WverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends; binds to the RPR1 RNAsubunit in Rnase P 0.003340.0786&radic&radic&radic&radic S000005158PEX17YNL214WverifiedPeroxisomal membrane protein component of the peroxisomaltranslocation machinery, required forperoxisome biogenesis, binds Pex14p 0.00330.07829&radic&radic S000004605YMR003WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria; YMR003W is not an essential gene 0.00330.07829&radic&radic&radic S000004846YMR233WUncharacterizedProtein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; YMR233W is not an essential gene 0.00330.07829&radic&radic&radic S000001592HAP4YKL109WverifiedSubunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5pCCAAT-binding complex, a transcriptionalactivator and global regulator of respiratorygene expression; provides the principalactivation function of the complex 0.003280.07761 S000004845FUS2YMR232WverifiedCytoplasmic protein localized to the shmoo tip; required forthe alignment of parental nuclei before nuclearfusion during mating 0.003290.07761&radic&radic&radic S000000457SRB6YBR253WverifiedEssentital subunit of the RNA polymerase II mediator complex;associates with core polymerase subunits toform the RNA polymerase II holoenzyme;essential for transcriptional regulation 0.003290.07761&radic S000004098YLR108CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene 0.00330.07761&radic&radic&radic S000003240STF2YGR008CverifiedProtein involved in regulation of the mitochondrial F1F0-ATPsynthase; Stf1p and Stf2p act as stabilizingfactors that enhance inhibitory action of theInh1p protein 0.003280.07761&radic&radic S000000635MATALPHA2YCR039CverifiedHomeobox-domain protein that, with Mcm1p, represses a-specificgenes in haploids; acts with A1p to represstranscription of haploid-specific genes indiploids; one of two genes encoded by theMATalpha mating type cassette 0.003290.07761 S000005383IFM1YOL023WverifiedMitochondrial translation initiation factor 2 0.003280.0776&radic&radic S000001530YKL047WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.003270.07689&radic&radic&radic S000000186MRP21YBL090WverifiedMitochondrial ribosomal protein of the large subunit; MRP21exhibits genetic interactions with mutations inthe COX2 and COX3 mRNA 5'-untranslated leadersequences 0.003260.07689&radic&radic S000004049REX2YLR059CverifiedRNA exonuclease, required for U4 snRNA maturation; functionsredundantly with Rnh70p in 5.8S rRNAmaturation, and with Rnh70p and Rex3p inprocessing of U5 snRNA and RNase P RNA; memberof RNase D family of exonucleases 0.003280.07689&radic S000000398SOY1YBR194WuncharacterizedProtein proposed to be associated with the nuclear pore complex 0.003270.07689&radic&radic&radic S000001307PIG2YIL045WverifiedPutative type-1 protein phosphatase targeting subunit thattethers Glc7p type-1 protein phosphatase toGsy2p glycogen synthase 0.003280.07689&radic&radic&radic S000003748OPT1YJL212CverifiedPlasma membrane transporter that transports tetra- andpentapeptides and glutathione; member of theOPT family 0.003270.07689&radic&radic S000005685SME1YOR159CverifiedCore Sm protein Sm E; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm E 0.003280.07689&radic&radic S000002718SUM1YDR310CverifiedTranscriptional repressor required for mitotic repression ofmiddle sporulation-specific genes; involved intelomere maintenance, regulated by thepachytene checkpoint 0.003260.07684&radic&radic S000005208PDR17YNL264CverifiedPhosphatidylinositol transfer protein (PITP), downregulatesPlb1p-mediated turnover of phosphatidylcholine,found in the cytosol and microsomes, homologousto Pdr16p, deletion affects phospholipidcomposition 0.003260.07683&radic&radic&radic S000000030PRP45YAL032CverifiedProtein required for pre-mRNA splicing; associates with thespliceosome and interacts with splicing factorsPrp22p and Prp46p; orthologous to humantranscriptional coactivator SKIP and canactivate transcription of a reporter gene 0.003240.07626&radic S000005936HST2YPL015CverifiedCytoplasmic member of the silencing information regulator 2(Sir2) family of NAD(+)-dependent proteindeacetylases; modulates nucleolar (rDNA) andtelomeric silencing; possesses NAD(+)-dependenthistone deacetylase activity in vitro 0.003260.07626&radic&radic S000005177BNI4YNL233WverifiedTargeting subunit for Glc7p protein phosphatase, localized tothe bud neck, required for localization ofchitin synthase III to the bud neck viainteraction with the chitin synthase IIIregulatory subunit Skt5p 0.003260.07626&radic&radic&radic S000004175RPL37AYLR185WverifiedProtein component of the large (60S) ribosomal subunit, hassimilarity to Rpl37Bp and to rat L37 ribosomalprotein 0.003240.07614&radic&radic S000002533SWF1YDR126WverifiedPalmitoyltransferase that acts on the SNAREs Snc1p, Syn8p,Tlg1p and likely on all SNAREs; member of afamily of putative palmitoyltransferasescontaining an Asp-His-His-Cys-cysteine rich(DHHC-CRD) domain; may have a role in vacuolefusion 0.003240.07614&radic S000002586CSN9YDR179CverifiedSubunit of the Cop9 signalosome, which is required fordeneddylation, or removal of the ubiquitin-likeprotein Rub1p from Cdc53p (cullin); involved inadaptation to pheromone signaling 0.003240.07597&radic&radic&radic&radic S000005165POP1YNL221CverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends; binds to the RPR1 RNAsubunit in Rnase P 0.003220.07547&radic&radic&radic S000005256RFA2YNL312WverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 0.003220.07547&radic&radic S000001922YFR026CUncharacterizedHypothetical protein 0.003230.07547&radic&radic&radic S000005405PSK2YOL045WverifiedOne of two (see also PSK1) PAS domain containing S/T proteinkinases; regulates sugar flux and translationin response to an unknown metabolite byphosphorylating Ugp1p and Gsy2p (sugar flux)and Caf20p, Tif11p and Sro9p (translation) 0.003220.07547&radic&radic&radic&radic S000000124YBL028CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis 0.003220.07547&radic S000006132NIP7YPL211WverifiedNucleolar protein required for 60S ribosome subunit biogenesis,constituent of 66S pre-ribosomal particles;physically interacts with Nop8p and the exosomesubunit Rrp43p 0.003220.07547&radic&radic&radic S000003925RTT109YLL002WverifiedProtein with a role in regulation of Ty1 transposition 0.003210.07526&radic&radic S000000103SLA1YBL007CverifiedCytoskeletal protein binding protein required for assembly ofthe cortical actin cytoskeleton; contains 3 SH3domains; interacts with proteins regulatingactin dynamics and with proteins required forendocytosis 0.003210.07526&radic&radic&radic&radic S000005784HNT3YOR258WverifiedMember of the third branch of the histidine triad (HIT)superfamily of nucleotide-binding proteins;similar to Aprataxin, a Hint related proteinthat is mutated in individuals with ataxia withoculomotor apraxia 0.003220.07526&radic&radic&radic S000001518UGP1YKL035WverifiedUDP-glucose pyrophosphorylase (UGPase), catalyses thereversible formation of UDP-Glc from glucose1-phosphate and UTP, involved in a wide varietyof metabolic pathways, expression modulated byPho85p through Pho4p 0.003210.07512&radic&radic&radic S000004815ERG2YMR202WverifiedC-8 sterol isomerase, catalyzes the isomerization of thedelta-8 double bond to the delta-7 position atan intermediate step in ergosterol biosynthesis 0.00320.07428&radic&radic&radic S000006349ASN1YPR145WverifiedAsparagine synthetase, isozyme of Asn2p; catalyzes thesynthesis of L-asparagine from L-aspartate inthe asparagine biosynthetic pathway 0.00320.07428&radic&radic&radic&radic S000001129YHR087WVerifiedProtein involved in RNA metabolism, one of two yeast homologs (with Sdo1p/Ylr022cp) of the human protein SBDS responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome, also conserved in Archaea 0.003210.07428&radic&radic&radic S000004368PSY3YLR376CuncharacterizedProtein of unknown function; deletion results in a mutatorphenotype suggesting a role for this protein asa mutational suppressor; deletion increasessensitivity to anticancer drugs oxaliplatin andcisplatin but not mitomycin C 0.003190.07428&radic&radic&radic&radic S000004267YSH1YLR277CverifiedPutative endonuclease, subunit of the mRNA cleavage andpolyadenylation specificity complex requiredfor 3' processing of mRNAs 0.00320.07428 S000005369MDM12YOL009CverifiedMitochondrial outer membrane protein, required for transmissionof mitochondria to daughter cells; exists in acomplex with Mmm1p and Mdm10p 0.003190.07428&radic&radic S000002201PRP11YDL043CverifiedSubunit of the SF3a splicing factor complex, required forspliceosome assembly 0.003190.07428 S000003044RPL7AYGL076CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl7Bp and has similarity to E.coli L30 and rat L7 ribosomal proteins;contains a conserved C-terminal Nucleic acidBinding Domain (NDB2) 0.003190.07428&radic&radic&radic&radic S000000777VMA8YEL051WverifiedSubunit D of the eight-subunit V1 peripheral membrane domain ofthe vacuolar H+-ATPase (V-ATPase), anelectrogenic proton pump found throughout theendomembrane system; plays a role in thecoupling of proton transport and ATP hydrolysis 0.003210.07428&radic&radic S000005023TPM1YNL079CverifiedMajor isoform of tropomyosin; binds to and stabilizes actincables and filaments, which direct polarizedcell growth and the distribution of severalorganelles; acetylated by the NatB complex andacetylated form binds actin most efficiently 0.00320.07428 S000003561APS3YJL024CverifiedSmall subunit of the clathrin-associated adaptor complex AP-3,which is involved in vacuolar protein sorting;related to the sigma subunit of the mammalianclathrin AP-3 complex; suppressor of loss ofcasein kinase 1 function 0.003180.07415&radic S000001034YHL042WUncharacterizedPutative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins 0.003180.07415&radic&radic S000005760RPL33BYOR234CverifiedRibosomal protein L37 of the large (60S) ribosomal subunit,nearly identical to Rpl33Ap and has similarityto rat L35a; rpl33b null mutant exhibits normalgrowth while rpl33a rpl33b double null mutantis inviable 0.003180.07415&radic&radic&radic&radic S000002572TRM82YDR165WverifiedSubunit of a tRNA methyltransferase complex composed of Trm8pand Trm82p that catalyzes 7-methylguanosinemodification of tRNA 0.003180.07414&radic&radic&radic S000002536SAC6YDR129CverifiedFimbrin, actin-bundling protein; cooperates with Scp1p(calponin/transgelin) in the organization andmaintenance of the actin cytoskeleton 0.003180.07414&radic&radic S000002205SIT4YDL047WverifiedType 2A-related serine-threonine phosphatase that functions inthe G1/S transition of the mitotic cycle;cytoplasmic and nuclear protein that modulatesfunctions mediated by Pkc1p including cell walland actin cytoskeleton organization 0.003160.07357&radic S000002720SSF2YDR312WverifiedProtein required for ribosomal large subunit maturation,functionally redundant with Ssf1p; member ofthe Brix family 0.003180.07357&radic S000003402PSD2YGR170WverifiedPhosphatidylserine decarboxylase of the Golgi and vacuolarmembranes, converts phosphatidylserine tophosphatidylethanolamine 0.003170.07357&radic&radic S000001465YVH1YIR026CverifiedProtein phosphatase involved in vegetative growth at lowtemperatures, sporulation, and glycogenaccumulation; transcription induced by lowtemperature and nitrogen starvation; member ofthe dual-specificity family of proteinphosphatases 0.003170.07357&radic&radic&radic S000000359CNS1YBR155WverifiedTPR-containing co-chaperone; binds both Hsp82p (Hsp90) andSsa1p (Hsp70) and stimulates the ATPaseactivity of SSA1, ts mutants reduce Hsp82pfunction while over expression suppresses thephenotypes of an HSP82 ts allele and a cpr7deletion 0.003170.07357&radic S000005113PSD1YNL169CverifiedPhosphatidylserine decarboxylase of the mitochondrial innermembrane, converts phosphatidylserine tophosphatidylethanolamine 0.003170.07357&radic&radic&radic S000004228FAR10YLR238WverifiedProtein involved in G1 cell cycle arrest in response topheromone, in a pathway different from theFar1p-dependent pathway; interacts with Far3p,Far7p, Far8p, Far9p, and Far11p; potentialCdc28p substrate 0.003150.07235&radic&radic&radic S000005873REV1YOR346WverifiedDeoxycytidyl transferase, forms a complex with the subunits ofDNA polymerase zeta, Rev3p and Rev7p; involvedin repair of abasic sites in damaged DNA 0.003140.07235&radic&radic&radic S000006336RPS23BYPR132WverifiedRibosomal protein 28 (rp28) of the small (40S) ribosomalsubunit, required for translational accuracy;nearly identical to Rps23Ap and similar to E.coli S12 and rat S23 ribosomal proteins;deletion of both RPS23A and RPS23B is lethal 0.003130.07235&radic S000002731PEP7YDR323CverifiedMultivalent adaptor protein that facilitates vesicle-mediatedvacuolar protein sorting by ensuringhigh-fidelity vesicle docking and fusion, whichare essential for targeting of vesicles to theendosome; required for vacuole inheritance 0.003150.07235 S000003315GCD2YGR083CverifiedDelta subunit of the translation initiation factor eIF2B, theguanine-nucleotide exchange factor for eIF2;activity subsequently regulated byphosphorylated eIF2; first identified as anegative regulator of GCN4 expression 0.003140.07235&radic&radic&radic&radic S000005635INP53YOR109WverifiedPhosphatidylinositol 4,5-bisphosphate 5-phosphatase,synaptojanin-like protein with an N-terminalSac1 domain, plays a role in a TGN (trans Golginetwork)-to-early endosome pathway;hyperosmotic stress causes translocation toactin patches 0.003130.07235&radic&radic&radic S000002790RPP2BYDR382WverifiedRibosomal protein P2 beta, a component of the ribosomal stalk,which is involved in the interaction betweentranslational elongation factors and theribosome; regulates the accumulation of P1(Rpp1Ap and Rpp1Bp) in the cytoplasm 0.003130.07235&radic&radic&radic S000002723IPK1YDR315CverifiedInositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear proteinrequired for synthesis of1,2,3,4,5,6-hexakisphosphate (phytate), whichis integral to cell function; has 2 motifsconserved in other fungi; ipk1 gle1 doublemutant is inviable 0.003150.07235&radic&radic&radic S000006323CLB2YPR119WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the transition from G2 to Mphase; accumulates during G2 and M, thentargeted via a destruction box motif forubiquitin-mediated degradation by theproteasome 0.003140.07235&radic&radic S000000104HIR1YBL008WverifiedNon-essential transcriptional corepressor involved in the cellcycle-regulated transcription of histone H2A,H2B, H3 and H4 genes; contributes to nucleosomeformation, heterochromatic gene silencing, andformation of functional kinetochores 0.003130.07235&radic&radic S000005786GCD1YOR260WverifiedGamma subunit of the translation initiation factor eIF2B, theguanine-nucleotide exchange factor for eIF2;activity subsequently regulated byphosphorylated eIF2; first identified as anegative regulator of GCN4 expression 0.003150.07235&radic&radic&radic&radic S000005655YOR129CVerifiedPutative component of the outer plaque of the spindle pole body; may be involved in cation homeostasis or multidrug resistance 0.003130.07235&radic&radic&radic S000001665FAS1YKL182WverifiedBeta subunit of fatty acid synthetase, which catalyzes thesynthesis of long-chain saturated fatty acids;contains acetyltransacylase, dehydratase, enoylreductase, malonyl transacylase, and palmitoyltransacylase activities 0.003150.07235&radic&radic&radic&radic S000001640APE2YKL157WverifiedZinc-dependent metallopeptidase yscII, may have a role inobtaining leucine from dipeptide substrates;sequence coordinates have changed since RT-PCRanalysis showed that the adjacent ORF YKL158Wcomprises the 5' exon of APE2/YKL157W 0.003150.07235&radic&radic&radic&radic S000006146YPL225WUncharacterizedHypothetical protein 0.003150.07235&radic&radic&radic&radic S000003993YLR003CUncharacterizedPutative protein of unknown function that may participate in DNA replication; green fluorescent protein (GFP)-fusion protein is localized to the nucleus; YLR003C is not an essential gene 0.003150.07235&radic&radic&radic&radic S000001093COX6YHR051WverifiedSubunit VI of cytochrome c oxidase, which is the terminalmember of the mitochondrial inner membraneelectron transport chain; expression isregulated by oxygen levels 0.003150.07235&radic S000001939IRC6YFR043CuncharacterizedHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 0.003150.07235&radic&radic&radic S000001081MSC7YHR039CverifiedProtein of unknown function, green fluorescent protein(GFP)-fusion protein localizes to theendoplasmic reticulum; msc7 mutants aredefective in directing meiotic recombinationevents to homologous chromatids 0.003130.07235&radic&radic S000001076PIH1YHR034CverifiedProtein of unresolved function; may function in protein foldingand/or rRNA processing, interacts with achaperone (Hsp82p), two chromatin remodelingfactors (Rvb1p, Rvb2p) and two rRNA processingfactors (Rrp43p, Nop58p) 0.003150.07235&radic&radic&radic S000001547MNR2YKL064WverifiedPutative magnesium transporter; has similarity to Alr1p andAlr2p, which mediate influx of Mg2+ and otherdivalent cations 0.003140.07235&radic&radic S000006161HSP82YPL240CverifiedCytoplasmic chaperone (Hsp90 family) required for pheromonesignaling and negative regulation of Hsf1p;docks with the mitochondrial import receptorTom70p for preprotein delivery; interacts withco-chaperones Cns1p, Cpr6p, Cpr7p, and Sti1p 0.00310.07126&radic&radic S000005989YPL068CUncharacterizedHypothetical protein 0.00310.07126&radic&radic S000000471REI1YBR267WverifiedCytoplasmic pre-60S factor; required for the correct recyclingof shuttling factors Alb1, Arx1 and Tif6 at theend of the ribosomal large subunit biogenesis;involved in bud growth in the mitotic signalingnetwork 0.003110.07126&radic&radic&radic&radic S000006032CAR1YPL111WverifiedArginase, responsible for arginine degradation, expressionresponds to both induction by arginine andnitrogen catabolite repression; disruptionenhances freeze tolerance 0.00310.07126&radic&radic&radic S000004772DNF3YMR162CverifiedAminophospholipid translocase (flippase) that maintainsmembrane lipid asymmetry in post-Golgisecretory vessicles; localizes to thetrans-Golgi network; likely involved in proteintransport; type 4 P-type ATPase 0.003110.07126&radic&radic S000004010YEH2YLR020CverifiedSteryl ester hydrolase, catalyzes steryl ester hydrolysis atthe plasma membrane; involved in sterolmetabolism 0.003110.07126&radic&radic&radic S000000056BDH1YAL060WverifiedNAD-dependent (2R,3R)-2,3-butanediol dehydrogenase, azinc-containing medium-chain alcoholdehydrogenase, produces 2,3-butanediol fromacetoin during fermentation and allows using2,3-butanediol as a carbon source duringaerobic growth 0.003110.07126&radic&radic S000004319TMA10YLR327CverifiedProtein of unknown function that associates with ribosomes 0.003110.07126&radic&radic S000003266RPL26BYGR034WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl26Ap and has similarity to E.coli L24 and rat L26 ribosomal proteins; bindsto 5.8S rRNA 0.003110.07126&radic&radic&radic&radic S000004200CLB4YLR210WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the G2/M transition; may beinvolved in DNA replication and spindleassembly; accumulates during S phase and G2,then targeted for ubiquitin-mediateddegradation 0.003110.07126&radic&radic S000001680PEX1YKL197CverifiedAAA-family ATPase peroxin required for peroxisome biogenesis,contains two 230 amino acid ATP-binding AAAcassettes, upregulated in anaerobiosis; Pex1pand Pex6p interact via their N-terminalAAA-cassettes 0.00310.07126&radic S000001219FMO1YHR176WverifiedFlavin-containing monooxygenase, localized to the cytoplasmicface of the ER membrane; catalyzes oxidation ofbiological thiols to maintain the ER redoxbuffer ratio for correct folding ofdisulfide-bonded proteins 0.003110.07126&radic&radic&radic S000004366YLR374CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W 0.003110.07126&radic&radic&radic S000006276NOT5YPR072WverifiedSubunit of the CCR4-NOT complex, which is a globaltranscriptional regulator with roles intranscription initiation and elongation and inmRNA degradation 0.00310.07126&radic S000001297CKA1YIL035CverifiedAlpha catalytic subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA2, CKB1 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.00310.07126&radic&radic&radic S000005116APC1YNL172WverifiedLargest subunit of the Anaphase-Promoting Complex/Cyclosome(APC/C), which is a ubiquitin-protein ligaserequired for degradation of anaphaseinhibitors, including mitotic cyclins, duringthe metaphase/anaphase transition 0.00310.07126&radic&radic S000004229LIP2YLR239CverifiedLipoyl ligase, involved in the modification of mitochondrialenzymes by the attachment of lipoic acid groups 0.003120.07126&radic&radic&radic S000005429HST1YOL068CverifiedNAD(+)-dependent histone deacetylase; essential subunit of theSum1p/Rfm1p/Hst1p complex required forORC-dependent silencing and mitotic repression;non-essential subunit of the Set3C deacetylasecomplex; involved in telomere maintenance 0.003090.07113&radic&radic&radic&radic&radic S000006274MED1YPR070WverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation 0.00310.07113 S000003258YGR026WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery 0.00310.07113&radic&radic&radic&radic S000001766GLG1YKR058WverifiedSelf-glucosylating initiator of glycogen synthesis, alsoglucosylates n-dodecyl-beta-D-maltoside;similar to mammalian glycogenin 0.003090.07097&radic&radic&radic S000003330ESP1YGR098CverifiedSeparase with cysteine protease activity (related to caspases)that promotes sister chromatid separation bymediating dissociation of the cohesin Scc1pfrom chromatin; inhibited by Pds1p 0.003090.07097&radic&radic&radic&radic S000000472MRPL37YBR268WverifiedMitochondrial ribosomal protein of the large subunit 0.003080.07076&radic S000004213IFH1YLR223CverifiedEssential protein with a highly acidic N-terminal domain; IFH1exhibits genetic interactions with FHL1,overexpression interferes with silencing attelomeres and HM loci; potential Cdc28psubstrate 0.003090.07076&radic&radic S000003276RME1YGR044CverifiedZinc finger protein involved in control of meiosis; preventsmeiosis by repressing IME1 expression andpromotes mitosis by activating CLN2 expression;directly repressed by a1-a2 regulator; mediatescell type control of sporulation 0.003090.07076&radic&radic&radic S000004921SCW10YMR305CverifiedCell wall protein with similarity to glucanases; may play arole in conjugation during mating based onmutant phenotype and its regulation by Ste12p 0.003080.07047&radic&radic&radic S000006363KRE6YPR159WverifiedProtein required for beta-1,6 glucan biosynthesis; putativebeta-glucan synthase; appears functionallyredundant with Skn1p 0.003080.07047&radic S000004180MMR1YLR190WverifiedPhosphorylated protein of the mitochondrial outer membrane,localizes only to mitochondria of the bud;interacts with Myo2p to mediate mitochondrialdistribution to buds; mRNA is targeted to thebud via the transport system involving She2p 0.003080.07047&radic&radic&radic S000002602MSS116YDR194CverifiedDEAD-box protein required for efficient splicing ofmitochondrial Group I and II introns; non-polarRNA helicase that also facilities strandannealing 0.003080.07047 S000000770IES6YEL044WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.003070.07047 S000001562SMY1YKL079WverifiedProtein that interacts with Myo2p, proposed to be involved inexocytosis; N-terminal domain is related to themotor domain of kinesins 0.003070.07047&radic&radic&radic&radic S000006180APM1YPL259CverifiedMu1-like medium subunit of the clathrin-associated proteincomplex (AP-1); binds clathrin; involved inclathrin-dependent Golgi protein sorting 0.003070.07032&radic&radic&radic S000005963SSN3YPL042CverifiedCyclin-dependent protein kinase, component of RNA polymerase IIholoenzyme; involved in phosphorylation of theRNA polymerase II C-terminal domain; involvedin glucose repression 0.003070.07032&radic S000003998PAM18YLR008CverifiedConstituent of the mitochondrial import motor associated withthe presequence translocase, along with Ssc1p,Tim44p, Mge1p, and Pam16p; stimulates theATPase activity of Ssc1p to drive mitochondrialimport; contains a J domain 0.003070.07032&radic&radic S000004187SIK1YLR197WverifiedEssential evolutionarily-conserved nucleolar protein componentof the box C/D snoRNP complexes that direct2'-O-methylation of pre-rRNA during itsmaturation; overexpression causes spindleorientation defects 0.003060.06956 S000000820SPC25YER018CverifiedComponent of the evolutionarily conservedkinetochore-associated Ndc80 complex(Ndc80p-Nuf2p-Spc24p-Spc25p); involved inchromosome segregation, spindle checkpointactivity and kinetochore clustering 0.003070.06956&radic&radic&radic S000000400PGI1YBR196CverifiedGlycolytic enzyme phosphoglucose isomerase, catalyzes theinterconversion of glucose-6-phosphate andfructose-6-phosphate; required for cell cycleprogression and completion of the gluconeogenicevents of sporulation 0.003050.06956&radic&radic S000003461SMI1YGR229CverifiedProtein involved in the regulation of cell wall synthesis;proposed to be involved in coordinating cellcycle progression with cell wall integrity 0.003050.06956&radic S000001116QNS1YHR074WverifiedGlutamine-dependent NAD(+) synthetase, essential for theformation of NAD(+) from nicotinic acid adeninedinucleotide 0.003060.06956&radic&radic&radic&radic S000004005BRE2YLR015WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres;involved in telomere maintenance; similar totrithorax-group protein ASH2L 0.003060.06956&radic S000003711YJL175WDubiousHypothetical protein 0.003060.06956 S000005562PEP12YOR036WverifiedTarget membrane receptor (t-SNARE) for vesicular intermediatestraveling between the Golgi apparatus and thevacuole; controls entry of biosynthetic,endocytic, and retrograde traffic into theprevacuolar compartment; syntaxin 0.003060.06956&radic&radic&radic S000000077YAR029WUncharacterizedMember of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.003070.06956&radic&radic&radic&radic S000004900DSS1YMR287CverifiedRNase, component of the mitochondrial degradosome along withthe ATP-dependent RNA helicase Suv3p; thedegradosome associates with the ribosome andmediates turnover of aberrant or unprocessedRNAs 0.003060.06956&radic S000006357YPR153WUncharacterizedHypothetical protein 0.003050.06956&radic&radic&radic S000006120YPL199CUncharacterizedHypothetical protein 0.003040.06925&radic&radic&radic&radic S000004011IRC25YLR021WuncharacterizedPutative protein of unknown function; mutant accumulatesunusually high amounts of dityrosine in thesoluble fraction though spores appearwild-type; YLR021W is not an essential gene;null mutant displays increased levels ofspontaneous Rad52 foci 0.003050.06925&radic&radic&radic S000000887YER085CUncharacterizedHypothetical protein 0.003040.06925&radic&radic&radic S000005890PIP2YOR363CverifiedAutoregulatory oleate-specific transcriptional activator ofperoxisome proliferation, contains Zn(2)-Cys(6)cluster domain, forms heterodimer with Oaf1p,binds oleate response elements (OREs),activates beta-oxidation genes 0.003040.06925&radic&radic&radic S000001075YHR033WUncharacterizedPutative protein of unknown function; epitope-tagged protein localizes to the cytoplasm 0.003040.06925&radic&radic S000002971CDH1YGL003CverifiedCell-cycle regulated activator of the anaphase-promotingcomplex/cyclosome (APC/C), which directsubiquitination of mitotic cyclins resulting inexit from mitosis; targets the APC/C tospecific substrates including CDC20, ASE1 andCIN8 0.003040.06919 S000001753YKR045CUncharacterizedPutative protein of unknown function; epitope-tagged protein localizes to the cytoplasm 0.003040.06919&radic&radic&radic&radic S000001885CDC4YFL009WverifiedF-box protein required for G1/S and G2/M transition, associateswith Skp1p and Cdc53p to form a complex,SCFCdc4, which acts as ubiquitin-protein ligasedirecting ubiquitination of the phosphorylatedCDK inhibitor Sic1p 0.003030.069&radic&radic S000002691GCN2YDR283CverifiedProtein kinase, phosphorylates the alpha-subunit of translationinitiation factor eIF2 (Sui2p) in response tostarvation; activated by uncharged tRNAs andthe Gcn1p-Gcn20p complex 0.003030.069&radic&radic S000001111RRP4YHR069CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp41p, Rrp42p,Rrp43p and Dis3p 0.003030.069&radic&radic&radic S000005258DAL82YNL314WverifiedPositive regulator of allophanate inducible genes; binds adodecanucleotide sequence upstream of all genesthat are induced by allophanate; contains anUISALL DNA-binding, a transcriptionalactivation, and a coiled-coil domain 0.003030.069&radic S000000181BOI1YBL085WverifiedProtein implicated in polar growth, functionally redundant withBoi2p; interacts with bud-emergence proteinBem1p; contains an SH3 (src homology 3) domainand a PH (pleckstrin homology) domain 0.003030.06886&radic&radic S000001576MBR1YKL093WverifiedProtein involved in mitochondrial functions and stressresponse; overexpression suppresses growthdefects of hap2, hap3, and hap4 mutants 0.003030.06886&radic&radic&radic S000005668LSC1YOR142WverifiedAlpha subunit of succinyl-CoA ligase, which is a mitochondrialenzyme of the TCA cycle that catalyzes thenucleotide-dependent conversion of succinyl-CoAto succinate 0.003030.06886&radic&radic&radic S000005417GPM3YOL056WverifiedHomolog of Gpm1p phosphoglycerate mutase, which converts3-phosphoglycerate to 2-phosphoglycerate inglycolysis; may be non-functional derivative ofa gene duplication event 0.003020.06847&radic&radic&radic&radic S000005923SNF8YPL002CverifiedComponent of the ESCRT-II complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; appears to be functionallyrelated to SNF7; involved in glucosederepression 0.003020.06847&radic S000002104RPL2AYFR031C-AverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl2Bp and has similarity to E.coli L2 and rat L8 ribosomal proteins 0.003020.06847&radic&radic&radic&radic S000002824SYF1YDR416WverifiedComponent of the spliceosome complex involved in pre-mRNAsplicing; involved in regulation of cell cycleprogression; similar to Drosophila crooked neckprotein 0.003020.06847 S000004409VPS36YLR417WverifiedComponent of the ESCRT-II complex; contains the GLUE (GRAM LikeUbiquitin binding in EAP45) domain which isinvolved in interactions with ESCRT-I andubiquitin-dependent sorting of proteins intothe endosome 0.003020.06847&radic&radic&radic S000005189CWC25YNL245CverifiedComponent of a complex containing Cef1p, involved in pre-mRNAsplicing; has similarity to S. pombe Cwf25p 0.003020.06847&radic&radic&radic S000003726RPS22AYJL190CverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps22Bp and has similarity to E.coli S8 and rat S15a ribosomal proteins 0.003010.06847&radic&radic S000006163IQG1YPL242CverifiedEssential protein required for determination of buddingpattern, promotes localization of axial markersBud4p and Cdc12p and functionally interactswith Sec3p, localizes to the contractile ringduring anaphase, member of the IQGAP family 0.003020.06847&radic&radic S000005996GCR1YPL075WverifiedTranscriptional activator of genes involved in glycolysis;DNA-binding protein that interacts andfunctions with the transcriptional activatorGcr2p 0.003020.06847&radic&radic&radic S000000517GBP2YCL011CverifiedPoly(A+) RNA-binding protein, involved in the export of mRNAsfrom the nucleus to the cytoplasm; similar toHrb1p and Npl3p; also binds single-strandedtelomeric repeat sequence in vitro 0.003020.06847&radic&radic S000005570IRC23YOR044WuncharacterizedPutative protein of unknown function; green fluorescent protein(GFP)-fusion localizes to the ER; null mutantdisplays increased levels of spontaneous Rad52foci 0.003020.06847&radic S000005613YVC1YOR087WverifiedVacuolar cation channel, mediates release of Ca(2+) from thevacuole in response to hyperosmotic shock 0.003020.06847&radic&radic&radic&radic S000005750RPB8YOR224CverifiedRNA polymerase subunit ABC14.5, common to RNA polymerases I,II, and III 0.003010.06808&radic&radic&radic S000003399CLC1YGR167WverifiedClathrin light chain, subunit of the major coat proteininvolved in intracellular protein transport andendocytosis; thought to regulate clathrinfunction, two Clathrin heavy chains (CHC1) formthe clathrin triskelion structural component 0.003010.06808&radic&radic&radic S000006359NCA2YPR155CverifiedProtein involved in regulation of mitochondrial expression ofsubunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1ATP synthase; functions with Nca3p 0.003010.06808&radic&radic S000004850BCH1YMR237WverifiedMember of the Chs5p-Arf1p-binding proteins (ChAPs), a group of4 related, interacting proteins (Bch1p, Fmp50p,Bud7p, Chs6p) that mediate export of specificcargo proteins, including chitin synthaseChs3p; may interact with ribosomes 0.003010.06808&radic&radic S000003440SER2YGR208WverifiedPhosphoserine phosphatase of the phosphoglycerate pathway,involved in serine and glycine biosynthesis,expression is regulated by the availablenitrogen source 0.003010.06808&radic&radic S000002683BSC2YDR275WverifiedProtein of unknown function, ORF exhibits genomic organizationcompatible with a translationalreadthrough-dependent mode of expression 0.0030.06808&radic&radic&radic S000001103GIC1YHR061CverifiedProtein of unknown function involved in initiation of buddingand cellular polarization, interacts withCdc42p via the Cdc42/Rac-interactive binding(CRIB) domain 0.003010.06808&radic&radic&radic&radic S000005820RRS1YOR294WverifiedEssential protein that binds ribosomal protein L11 and isrequired for nuclear export of the 60Spre-ribosomal subunit during ribosomebiogenesis; mouse homolog shows alteredexpression in Huntington's disease model mice 0.0030.06782&radic&radic