Yfunc lets you browse current and predicted gene functions in yeast

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Prediction of GO:0008168 "methyltransferase activity"

GO branch: MF
Number of currently annotated genes: 82

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest Huh:nucleusHuh:cytoplasmLum:GliotoxinLum:MMSHarbison:IME1_H2O2HiHarbison:UGA3_YPDHarbison:YPR022C_YPDLum:DMSOLum:AsulamLum:Staurosporine S000001161SET1YHR119WverifiedHistone methyltransferase, subunit of the COMPASS (Set1C)complex which methylates histone H3 on lysine4; required in transcriptional silencing neartelomeres and at the silent mating type loci;contains a SET domain &radic0.553520.95823&radic&radic S000000064SWD1YAR003WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres; WD40beta propeller superfamily member withsimilarity to mammalian Rbbp7 &radic0.4450.93469&radic&radic&radic&radic&radic S000002547MTQ2YDR140WuncharacterizedS-adenosylmethionine-dependent methyltransferase of the sevenbeta-strand family; methylates release factoreRF1 (Sup45p) in vitro; is not an essentialgene; similar to E.coli PrmC &radic0.425390.93469&radic&radic&radic&radic&radic&radic&radic S000004005BRE2YLR015WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres;involved in telomere maintenance; similar totrithorax-group protein ASH2L &radic0.432770.93469&radic&radic&radic&radic&radic S000000379SWD3YBR175WverifiedEssential subunit of the COMPASS (Set1C) complex, whichmethylates histone H3 on lysine 4 and isrequired in transcriptional silencing neartelomeres; WD40 beta propeller superfamilymember and ortholog of mammalian WDR5 &radic0.446080.93469&radic&radic&radic&radic&radic S000004467ERG6YML008CverifiedDelta(24)-sterol C-methyltransferase, converts zymosterol tofecosterol in the ergosterol biosyntheticpathway by methylating position C-24; localizedto both lipid particles and mitochondrial outermembrane &radic0.414990.93469&radic S000005484TRM11YOL124CverifiedCatalytic subunit of an adoMet-dependent tRNA methyltransferasecomplex (Trm11p-Trm112p), required for themethylation of the guanosine nucleotide atposition 10 (m2G10) in tRNAs; contains a THUMPdomain and a methyltransferase domain &radic0.356330.92332&radic S000002877SDC1YDR469WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres; hassimilarity to C. elegans Dpy-30 &radic0.356010.92332&radic&radic&radic&radic S000006059SPP1YPL138CverifiedSubunit of COMPASS (Set1C), a complex which methylates histoneH3 on lysine 4 and is required in telomerictranscriptional silencing; PHD finger domainprotein similar to human CGBP, an unmethylatedCpG binding protein &radic0.325150.90476&radic&radic&radic S000004018ADE16YLR028CverifiedEnzyme of 'de novo' purine biosynthesis containing both5-aminoimidazole-4-carboxamide ribonucleotidetransformylase and inosine monophosphatecyclohydrolase activities, isozyme of Ade17p;ade16 ade17 mutants require adenine andhistidine &radic0.311680.89937&radic&radic&radic S000000559SPB1YCL054WverifiedAdoMet-dependent methyltransferase involved in rRNA processingand 60S ribosomal subunit maturation;methylates G2922 in the tRNA docking site ofthe large subunit rRNA and in the absence ofsnR52, U2921; suppressor of PAB1 mutants &radic0.308850.89895&radic&radic&radic&radic&radic S000004727ADE17YMR120CverifiedEnzyme of 'de novo' purine biosynthesis containing both5-aminoimidazole-4-carboxamide ribonucleotidetransformylase and inosine monophosphatecyclohydrolase activities, isozyme of Ade16p;ade16 ade17 mutants require adenine andhistidine &radic0.304020.89642&radic S000004476TRM9YML014WverifiedtRNA methyltransferase, catalyzes the esterification ofmodified uridine nucleotides in tRNAs, creating5-methylcarbonylmethyluridine in tRNA(Arg3) and5-methylcarbonylmethyl-2-thiouridine intRNA(Glu); may have a role in stress response &radic0.286570.88629&radic&radic&radic&radic S000001326YIL064WUncharacterizedPutative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family &radic0.27580.88474&radic&radic&radic&radic&radic S000002476DOA4YDR069CverifiedUbiquitin hydrolase, required for recycling ubiquitin fromproteasome-bound ubiquitinated intermediates,acts at the late endosome/prevacuolarcompartment to recover ubiquitin fromubiquitinated membrane proteins en route to thevacuole 0.269870.88238&radic&radic&radic&radic&radic S000001252CRG1YHR209WuncharacterizedPutative S-adenosylmethionine-dependent methyltransferase;mediates cantharidin resistance &radic0.269430.88238&radic&radic&radic&radic&radic&radic S000000643BUD23YCR047CverifiedProtein involved in bud-site selection; diploid mutants displaya random budding pattern instead of thewild-type bipolar pattern &radic0.266750.88169&radic&radic S000000977TMT1YER175CverifiedTrans-aconitate methyltransferase, cytosolic enzyme thatcatalyzes the methyl esterification of3-isopropylmalate, an intermediate of theleucine biosynthetic pathway, andtrans-aconitate, which inhibits the citric acidcycle &radic0.24160.86522&radic S000005765ABP140YOR239WverifiedNonessential protein that binds actin filaments and localizesto actin patches and cables, has similarity toS-adenosylmethionine (AdoMet)-dependentmethyltransferases &radic0.232760.85876&radic&radic&radic&radic&radic S000002724OMS1YDR316WverifiedProtein integral to the mitochondrial membrane; has a conservedmethyltransferase motif; multicopy suppressorof respiratory defects caused by OXA1 mutations &radic0.232750.85876&radic&radic S000005456COQ3YOL096CverifiedO-methyltransferase, catalyzes two different O-methylationsteps in ubiquinone (Coenzyme Q) biosynthesis;component of a mitochondrialubiquinone-synthesizing complex &radic0.228720.85529&radic&radic S000003874RSM7YJR113CverifiedMitochondrial ribosomal protein of the small subunit, hassimilarity to E. coli S7 ribosomal protein 0.226580.85273 S000001106SSZ1YHR064CverifiedHsp70 protein that interacts with Zuo1p (a DnaJ homolog) toform a ribosome-associated complex that bindsthe ribosome via the Zuo1p subunit; alsoinvolved in pleiotropic drug resistance viasequential activation of PDR1 and PDR5; bindsATP 0.212050.83841&radic&radic S000005007MTQ1YNL063WuncharacterizedS-adenosylmethionine-dependent Methyltransferase; methylatestranslational release factor Mrf1p; similar toE.coli PrmC; is not an essential gene &radic0.200030.82692&radic S000004940YMR321CUncharacterizedHypothetical protein 0.186460.81062 S000005005NOP2YNL061WverifiedProbable RNA m(5)C methyltransferase, essential for processingand maturation of 27S pre-rRNA and largeribosomal subunit biogenesis; localized to thenucleolus; constituent of 66S pre-ribosomalparticles &radic0.169980.79505&radic&radic S000003104MRM2YGL136CverifiedMitochondrial 21S rRNA methyltransferase, required formethylation of U(2791) in 21S rRNA; MRM2deletion confers thermosensitive respirationand loss of mitochondrial DNA; has similarityto Spb1p and Trm7p, and to E. coli FtsJ/RrmJ &radic0.169530.7941 S000000265TRM7YBR061Cverified2'-O-ribose methyltransferase, methylates the 2'-O-ribose ofnucleotides at positions 32 and 34 of the tRNAanticodon loop &radic0.163130.78389&radic&radic&radic S000000560KAR4YCL055WverifiedTranscription factor required for gene regulation in repsonseto pheromones; also required during meiosis;exists in two forms, a slower-migrating formmore abundant during vegetative growth and afaster-migrating form induced by pheromone 0.156940.77748&radic&radic&radic&radic&radic&radic S000000467SHM1YBR263WverifiedMitochondrial serine hydroxymethyltransferase, involved inone-carbon metabolism &radic0.153870.77449&radic&radic&radic S000004048SHM2YLR058CverifiedCytosolic serine hydroxymethyltransferase, involved inone-carbon metabolism &radic0.147110.76365&radic&radic&radic&radic&radic&radic S000003233YGR001CUncharacterizedPutative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae &radic0.147040.76348&radic&radic&radic S000004464TRM12YML005WverifiedS-adenosylmethionine-dependent methyltransferase of the sevenbeta-strand family; required for wybutosineformation in phenylalanine-accepting tRNA &radic0.134340.74365&radic&radic&radic&radic S000005501PPM2YOL141WverifiedPutative carboxyl methyl transferase, has similarity to Ppm1pbut biochemical activity not yet demonstrated;the authentic, non-tagged protein is detectedin highly purified mitochondria inhigh-throughput studies &radic0.12470.72635&radic&radic S000004967YNL022CUncharacterizedPutative protein of unknown function with seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to a single spot in the nucleus; YNL022C is not an essential gene 0.12170.72315&radic&radic S000002816ADE8YDR408CverifiedPhosphoribosyl-glycinamide transformylase, catalyzes a step inthe 'de novo' purine nucleotide biosyntheticpathway &radic0.118930.71733&radic&radic&radic&radic S000001112TRM5YHR070WverifiedtRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacentto the anticodon that has a role in preventionof frameshifting; highly conserved acrossArchaea, Bacteria, and Eukarya &radic0.118730.7167&radic&radic&radic&radic&radic&radic&radic&radic&radic S000002843PPM1YDR435CverifiedCarboxyl methyl transferase, methylates the C terminus of theprotein phosphatase 2A catalytic subunit(Pph21p or Pph22p), which is important forcomplex formation with regulatory subunits &radic0.117770.71405&radic&radic&radic&radic S000004822YMR209CUncharacterizedPutative protein of unknown function; YMR209C is not an essential gene 0.113610.70636&radic S000005333LYS9YNR050CverifiedSaccharopine dehydrogenase (NADP+, L-glutamate-forming);catalyzes the formation of saccharopine fromalpha-aminoadipate 6-semialdehyde, which is theseventh step in lysine biosynthesis pathway 0.111060.70169&radic S000006012GLR1YPL091WverifiedCytosolic and mitochondrial glutathione oxidoreductase,converts oxidized glutathione to reducedglutathione 0.107010.69383&radic&radic&radic S000001876LPD1YFL018CverifiedDihydrolipoamide dehydrogenase, the lipoamide dehydrogenasecomponent (E3) of the pyruvate dehydrogenaseand 2-oxoglutarate dehydrogenase multi-enzymecomplexes 0.102050.68606&radic&radic S000006187DIM1YPL266WverifiedEssential 18S rRNA dimethylase, responsible for conservedm6(2)Am6(2)A dimethylation in 3'-terminal loopof 18 S rRNA, part of 90S and 40S pre-particlesin nucleolus, involved in pre-ribosomal RNAprocessing &radic0.100590.68448&radic&radic&radic&radic&radic&radic&radic S000004841MTF1YMR228WverifiedMitochondrial RNA polymerase specificity factor with structuralsimilarity to S-adenosylmethionine-dependentmethyltransferases and functional similarity tobacterial sigma-factors, interacts withmitochondrial core polymerase Rpo41p &radic0.099110.68216&radic&radic&radic&radic&radic&radic S000003985MHT1YLL062CverifiedS-methylmethionine-homocysteine methyltransferase, functionsalong with Sam4p in the conversion ofS-adenosylmethionine (AdoMet) to methionine tocontrol the methionine/AdoMet ratio &radic0.081120.63206&radic&radic&radic&radic S000006194SAM4YPL273WverifiedS-adenosylmethionine-homocysteine methyltransferase, functionsalong with Mht1p in the conversion ofS-adenosylmethionine (AdoMet) to methionine tocontrol the methionine/AdoMet ratio &radic0.079030.62435&radic&radic&radic&radic&radic&radic&radic S000003704SET2YJL168CverifiedHistone methyltransferase with a role in transcriptionalelongation, methylates a lysine residue ofhistone H3; associates with the C-terminaldomain of Rpo21p; histone methylation activityis regulated by phosphorylation status ofRpo21p &radic0.0750.61088&radic&radic&radic&radic&radic S000003145YGL177WDubiousHypothetical protein 0.069720.59195&radic&radic&radic S000001777MET1YKR069WverifiedS-adenosyl-L-methionine uroporphyrinogen III transmethylase,involved in sulfate assimilation, methioninemetabolism, and siroheme biosynthesis &radic0.069030.59013&radic&radic&radic&radic S000000120NCL1YBL024WverifiedS-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase,methylates cytosine to m5C at several positionsin tRNAs and intron-containing pre-tRNAs;similar to Nop2p and human proliferationassociated nucleolar protein p120 &radic0.062520.56679&radic&radic&radic&radic S000003666URA2YJL130CverifiedBifunctional carbamoylphosphate synthetase (CPSase)-aspartatetranscarbamylase (ATCase), catalyzes the firsttwo enzymatic steps in the de novo biosynthesisof pyrimidines; both activities are subject tofeedback inhibition by UTP 0.06050.55781&radic&radic&radic&radic&radic&radic S000000109FMT1YBL013WverifiedMethionyl-tRNA formyltransferase, catalyzes the formylation ofinitiator Met-tRNA in mitochondria; potentialCdc28p substrate &radic0.059090.5534&radic&radic&radic S000002910SAM2YDR502CverifiedS-adenosylmethionine synthetase, catalyzes transfer of theadenosyl group of ATP to the sulfur atom ofmethionine; one of two differentially regulatedisozymes (Sam1p and Sam2p) 0.056990.54119&radic&radic S000002607YDR199WDubiousHypothetical protein 0.051410.51611&radic&radic&radic&radic S000005263YNL319WDubiousDubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14 0.045250.48813&radic&radic&radic&radic&radic&radic S000001069RPN1YHR027CverifiedNon-ATPase base subunit of the 19S regulatory particle of the26S proteasome; may participate in therecognition of several ligands of theproteasome; contains a leucine-rich repeat(LRR) domain, a site for protein?proteininteractions 0.044310.48165&radic&radic&radic&radic&radic S000001219FMO1YHR176WverifiedFlavin-containing monooxygenase, localized to the cytoplasmicface of the ER membrane; catalyzes oxidation ofbiological thiols to maintain the ER redoxbuffer ratio for correct folding ofdisulfide-bonded proteins 0.044480.48165&radic S000001504MAK11YKL021CverifiedProtein essential for cell growth and replication of M dsRNAvirus; contains four beta-transducin repeats 0.043530.47986&radic&radic&radic&radic&radic&radic S000000867ICL1YER065CverifiedIsocitrate lyase, catalyzes the formation of succinate andglyoxylate from isocitrate, a key reaction ofthe glyoxylate cycle; expression of ICL1 isinduced by growth on ethanol and repressed bygrowth on glucose 0.041870.47216&radic&radic S000002744YDR336WUncharacterizedPutative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene 0.039720.4651&radic&radic&radic&radic&radic S000004045SPT8YLR055CverifiedSubunit of the SAGA transcriptional regulatory complex but notpresent in SAGA-like complex SLIK/SALSA,required for SAGA-mediated inhibition at somepromoters 0.038760.45954&radic&radic&radic S000005329TRM112YNR046WverifiedSubunit of an adoMet-dependent tRNA methyltransferase (MTase)complex (Trm11p-Trm112p), required for themethylation of the guanosine nucleotide atposition 10 (m2G10) in tRNAs; putative zincbinding subunit of other MTase-related proteins &radic0.037730.45661&radic&radic S000004754TIF34YMR146CverifiedSubunit of the core complex of translation initiation factor3(eIF3), which is essential for translation 0.036230.44894&radic&radic&radic S000003432ELP2YGR200CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;target of Kluyveromyces lactis zymocin 0.035780.44728&radic&radic&radic&radic&radic&radic S000004840TAF7YMR227CverifiedTFIID subunit (67 kDa), involved in RNA polymerase IItranscription initiation 0.034790.44149&radic&radic&radic&radic&radic&radic&radic&radic S000003322UTP22YGR090WuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.034690.44149&radic S000001308MET30YIL046WverifiedF-box protein containing five copies of the WD40 motif,controls cell cycle function, sulfurmetabolism, and methionine biosynthesis as partof the ubiquitin ligase complex; interacts withand regulates Met4p, localizes within thenucleus 0.034550.44134&radic&radic&radic&radic&radic&radic&radic S000002764SPC110YDR356WverifiedInner plaque spindle pole body (SPB) component, ortholog ofhuman kendrin; involved in connecting nuclearmicrotubules to SPB; interacts withTub4p-complex and calmodulin; phosphorylated byMps1p in cell cycle-dependent manner 0.033960.43807&radic&radic S000004162DPH5YLR172CverifiedMethyltransferase required for synthesis of diphthamide, whichis a modified histidine residue of translationelongation factor 2 (Eft1p or Eft2p); notessential for viability; GFP-Dph5p fusionprotein localizes to the cytoplasm &radic0.033830.43661&radic&radic&radic S000006383HDA3YPR179CverifiedSubunit of a possibly tetrameric trichostatin A-sensitive classII histone deacetylase complex that contains anHda1p homodimer and an Hda2p-Hda3p heterodimer;required for the activity of the complex; hassimilarity to Hda2p 0.032410.43037&radic&radic&radic&radic&radic S000003983GTT2YLL060CverifiedGlutathione S-transferase capable of homodimerization;functional overlap with Gtt2p, Grx1p, and Grx2p 0.031870.42736&radic&radic&radic&radic S000006382PRP4YPR178WverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.031490.42516&radic&radic&radic&radic&radic&radic&radic&radic S000003781YJR020WDubiousHypothetical protein 0.030610.41758&radic&radic S000001953YFR057WUncharacterizedHypothetical protein 0.030490.41758&radic&radic&radic S000005527RRP6YOR001WverifiedExonuclease component of the nuclear exosome; contributes tothe quality-control system that retains anddegrades aberrant mRNAs in the nucleus 0.030270.41758&radic&radic&radic&radic&radic&radic S000000302MMS4YBR098WverifiedSubunit of the structure-specific Mms4p-Mus81p endonucleasethat cleaves branched DNA; involved inrecombination and DNA repair 0.029630.41472&radic&radic&radic&radic S000004852RNT1YMR239CverifiedRNAase III; cleaves a stem-loop structure at the 3' end of U2snRNA to ensure formation of the correct U2 3'end 0.029490.41444&radic&radic&radic&radic&radic&radic S000000313CMD1YBR109CverifiedCalmodulin; Ca++ binding protein that regulates Ca++independent processes (mitosis, bud growth,actin organization, endocytosis, etc.) and Ca++dependent processes (stress-activatedpathways), targets include Nuf1p, Myo2p andcalcineurin 0.02870.40929 S000006168YPL247CUncharacterizedHypothetical protein 0.028140.40479&radic&radic&radic&radic&radic S000002840NPL3YDR432WverifiedRNA-binding protein that carries poly(A)+ mRNA from the nucleusinto the cytoplasm; phosphorylation by Sky1p inthe cytoplasm may promote release of mRNAs 0.027890.40401&radic&radic&radic&radic&radic S000002271ATG20YDL113CverifiedProtein required for transport of aminopeptidase I (Lap4p)through the cytoplasm-to-vacuole targetingpathway; bindsphosphatidylinositol-3-phosphate, involved inlocalization of membranes to thepreautophagosome, potential Cdc28p substrate 0.027710.40353&radic S000000399MSI1YBR195CverifiedSubunit of chromatin assembly factor I (CAF-I), regulates theRAS/cAMP pathway via sequestration of Npr1pkinase; localizes to the nucleus and cytoplasm;homologous to human retinoblastoma bindingproteins RbAp48 and RbAp46 0.027420.40169&radic&radic&radic&radic&radic&radic&radic&radic S000002229IRC1YDL071CdubiousHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 0.026820.39657&radic&radic&radic S000003201TAN1YGL232WverifiedPutative tRNA acetyltransferase, RNA-binding protein requiredfor the formation of the modified nucleosideN(4)-acetylcytidine in serine and leucine tRNAsbut not required for the same modification in18S rRNA 0.026850.39657&radic&radic&radic&radic&radic&radic&radic&radic&radic S000002226YDL068WDubiousHypothetical protein 0.026790.39657&radic&radic&radic S000003200YGL231CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum 0.026740.39631&radic&radic&radic&radic&radic S000000773YEL047CVerifiedFumurate ReDuctase Soluble 0.026350.39355&radic&radic&radic&radic&radic S000003778ESS1YJR017CverifiedPeptidylprolyl-cis/trans-isomerase (PPIase) specific forphosphorylated serine and threonine residuesN-terminal to proline; regulatesphosphorylation of the RNA polymerase II largesubunit (Rpo21p) C-terminal domain 0.025810.38911&radic&radic&radic&radic S000001153UBA4YHR111WverifiedProtein that activates Urm1p before its conjugation to proteins(urmylation); one target is the thioredoxinperoxidase Ahp1p, suggesting a role ofurmylation in the oxidative stress response 0.025840.38911&radic&radic&radic&radic&radic&radic S000002243NDE2YDL085WverifiedMitochondrial external NADH dehydrogenase, catalyzes theoxidation of cytosolic NADH; Nde1p and Nde2pare involved in providing the cytosolic NADH tothe mitochondrial respiratory chain 0.02550.38764 S000005025SWS2YNL081CuncharacterizedPutative mitochondrial ribosomal protein of the small subunit,has similarity to E. coli S13 ribosomal protein 0.025640.38764&radic S000001696DOA1YKL213CverifiedWD repeat protein required for ubiquitin-mediated proteindegradation, forms complex with Cdc48p, plays arole in controlling cellular ubiquitinconcentration; also promotes efficient NHEJ inpostdiauxic/stationary phase 0.024430.37639&radic&radic&radic&radic&radic S000004012SDO1YLR022CuncharacterizedEssential protein involved in RNA metabolism, one of two yeasthomologs (with Yhr087wp) of the human proteinSBDS responsible for autosomal recessiveShwachman-Bodian-Diamond Syndrome, alsoconserved in Archaea 0.023790.37374&radic&radic&radic&radic&radic&radic S000003196VID30YGL227WverifiedProtein involved in proteasome-dependent catabolite degradationof fructose-1,6-bisphosphatase (FBPase); shiftsthe balance of nitrogen metabolism toward theproduction of glutamate; localized to thenucleus and the cytoplasm 0.023420.37027&radic&radic&radic&radic&radic S000000794YEL068CDubiousHypothetical protein 0.023350.37027&radic&radic&radic&radic S000004198SEC13YLR208WverifiedComponent of both the Nup84 nuclear pore sub-complex and of theCOPII complex (Sar1p, Sec13p, Sec16p, Sec23p,Sec24p, Sec31p, Sfb2p, and Sfb3p) which isimportant for the formation of ER to Golgitransport vesicles 0.023410.37027&radic&radic&radic S000002538YDR131CUncharacterizedF-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex 0.023610.37027&radic&radic&radic&radic S000005756WTM1YOR230WverifiedTranscriptional repressor involved in regulation of meiosis andsilencing; contains WD repeats 0.023080.3684&radic&radic&radic S000004119DIP2YLR129WverifiedNucleolar protein, specifically associated with the U3 snoRNA,part of the large ribonucleoprotein complexknown as the small subunit (SSU) processome,required for 18S rRNA biogenesis, part of theactive pre-rRNA processing complex 0.022650.36439&radic&radic&radic&radic&radic S000002769BCP1YDR361CverifiedEssential protein involved in nuclear export of Mss4p, which isa lipid kinase that generatesphosphatidylinositol 4,5-biphosphate and playsa role in actin cytoskeleton organization andvesicular transport 0.022370.36296&radic&radic&radic&radic S000000782HAT2YEL056WverifiedSubunit of the Hat1p-Hat2p histone acetyltransferase complex;required for high affinity binding of thecomplex to free histone H4, thereby enhancingHat1p activity; similar to human RbAp46 and 48;has a role in telomeric silencing 0.022110.36111&radic&radic S000005228MRPL10YNL284CverifiedMitochondrial ribosomal protein of the large subunit; appearsas two protein spots (YmL10 and YmL18) ontwo-dimensional SDS gels 0.022190.36111 S000002789YRA1YDR381WverifiedNuclear protein that binds to RNA and to Mex67p, required forexport of poly(A)+ mRNA from the nucleus;member of the REF (RNA and export factorbinding proteins) family; another familymember, Yra2p, can substitute for Yra1pfunction 0.021970.35988&radic&radic&radic&radic&radic S000000682CSM1YCR086WverifiedNucleolar protein that forms a complex with Lrs4p which bindsMam1p at kinetochores during meiosis I tomediate accurate chromosome segregation, may beinvolved in premeiotic DNA replication;possible role in telomere maintenance 0.021960.35988&radic&radic&radic S000004470SPT5YML010WverifiedProtein that forms a complex with Spt4p and mediates bothactivation and inhibition of transcriptionelongation; Spt4p-Spt5p complex also plays arole in pre-mRNA processing 0.021930.35988&radic&radic&radic&radic S000006373JIP5YPR169WuncharacterizedNucleolar protein of unknown function, exhibits a physicalinteraction with Bre1p 0.021780.35885&radic&radic&radic&radic S000001029YHL037CDubiousHypothetical protein 0.021790.35885&radic&radic&radic&radic S000005738STE4YOR212WverifiedG protein beta subunit, forms a dimer with Ste18p to activatethe mating signaling pathway, forms aheterotrimer with Gpa1p and Ste18p to dampensignaling; may recruit Rho1p to the polarizedgrowth site during mating; contains WD40repeats 0.02160.3569&radic&radic&radic&radic S000004914DYN3YMR299CverifiedDynein light intermediate chain (LIC); localizes with dynein,null mutant is defective in nuclear migration 0.021540.3569&radic&radic&radic&radic&radic&radic&radic S000001034YHL042WUncharacterizedPutative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins 0.021470.35542&radic&radic S000000957BEM2YER155CverifiedRho GTPase activating protein (RhoGAP) involved in the controlof cytoskeleton organization and cellularmorphogenesis; required for bud emergence 0.021450.35542&radic S000005552BUB3YOR026WverifiedKinetochore checkpoint WD40 repeat protein that localizes tokinetochores during prophase and metaphase,delays anaphase in the presence of unattachedkinetochores; forms complexes with Mad1p-Bub1pand with Cdc20p, binds Mad2p and Mad3p 0.020870.35061&radic&radic&radic&radic&radic S000005147YNL203CDubiousHypothetical protein 0.020060.34365&radic&radic&radic&radic S000001587GFA1YKL104CverifiedGlutamine-fructose-6-phosphate amidotransferase, catalyzes theformation of glucosamine-6-P and glutamate fromfructose-6-P and glutamine in the first step ofchitin biosynthesis 0.020110.34365&radic&radic S000003934SOF1YLL011WverifiedEssential subunit of the U3 (box C+D) snRNP complex requiredfor 2' O-methylation of pre-RNA; has similarityto the beta subunit of trimeric G-proteins andthe splicing factor Prp4p 0.020140.34365&radic&radic&radic S000002505GRX3YDR098CverifiedHydroperoxide and superoxide-radical responsiveglutathione-dependent oxidoreductase; monothiolglutaredoxin subfamily member along with Grx4pand Grx5p; protects cells from oxidative damage 0.019950.3429&radic&radic&radic&radic&radic&radic S000000884UTP7YER082CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.019840.34096&radic&radic&radic S000001028MUP3YHL036WverifiedLow affinity methionine permease, similar to Mup1p 0.019850.34096&radic&radic&radic S000005651CAT5YOR125CverifiedMitochondrial inner membrane protein directly involved inubiquinone biosynthesis, essential for severalother metabolic pathways including respirationand gluconeogenic gene activation 0.019910.34096&radic&radic S000003622YJL086CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1 0.019840.34096&radic&radic S000003751YJL215CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data 0.019630.34047&radic&radic&radic&radic&radic S000001607SSH4YKL124WverifiedProtein whose overexpression confers resistance to the growthinhibitor leflunomide; suppressor of shr3mutation 0.019520.33959&radic&radic S000001805PCK1YKR097WverifiedPhosphoenolpyruvate carboxykinase, key enzyme ingluconeogenesis, catalyzes early reaction incarbohydrate biosynthesis, glucose repressestranscription and accelerates mRNA degradation,regulated by Mcm1p and Cat8p, located in thecytosol 0.019280.33745 S000002740IRC3YDR332WuncharacterizedHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 0.018980.3342&radic&radic&radic&radic&radic&radic S000002743MSN5YDR335WverifiedKaryopherin involved in nuclear import and export; shown to beresponsible for nuclear import of replicationprotein A and for export of several proteinsincluding Swi6p, Far1p, and Pho4p; cargodissociation involves binding to RanGTP 0.019090.3342&radic&radic&radic&radic S000000104HIR1YBL008WverifiedNon-essential transcriptional corepressor involved in the cellcycle-regulated transcription of histone H2A,H2B, H3 and H4 genes; contributes to nucleosomeformation, heterochromatic gene silencing, andformation of functional kinetochores 0.019090.3342&radic&radic&radic&radic&radic&radic S000005261PFS2YNL317WverifiedIntegral subunit of the pre-mRNA cleavage and polyadenylationfactor (CPF) complex; plays an essential rolein mRNA 3'-end formation by bridging differentprocessing factors and thereby promoting theassembly of the processing complex 0.018890.3342&radic&radic&radic S000005755WTM2YOR229WverifiedTranscriptional repressor involved in regulation of meiosis andsilencing; contains WD repeats 0.018620.33194&radic&radic&radic S000006339CTF4YPR135WverifiedChromatin-associated protein, required for sister chromatidcohesion; interacts with DNA polymerase alpha(Pol1p) and may link DNA synthesis to sisterchromatid cohesion 0.018640.33194&radic&radic&radic&radic&radic&radic S000004818PFK2YMR205CverifiedBeta subunit of heterooctameric phosphofructokinase involved inglycolysis, indispensable for anaerobic growth,activated by fructose-2,6-bisphosphate and AMP,mutation inhibits glucose induction of cellcycle-related genes 0.018410.32984&radic&radic&radic&radic&radic&radic S000004781YMR171CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to endosomes; mRNA is targeted to the bud via the mRNA transport system involving She2p: YMR171C is not an essential gene 0.01840.32984&radic&radic S000003046DBP3YGL078CverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in ribosomal biogenesis 0.018510.32984&radic&radic&radic&radic&radic&radic&radic S000000025YAL027WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YAL027W is a non-essential gene 0.018590.32984&radic&radic&radic&radic&radic S000004695YTA12YMR089CverifiedComponent, with Afg3p, of the mitochondrial inner membranem-AAA protease that mediates degradation ofmisfolded or unassembled proteins and is alsorequired for correct assembly of mitochondrialenzyme complexes 0.017910.32607 S000002597SLY1YDR189WverifiedHydrophilic protein involved in vesicle trafficking between theER and Golgi; SM (Sec1/Munc-18) family proteinthat binds the tSNARE Sed5p and stimulates itsassembly into a trans-SNARE membrane-proteincomplex 0.017980.32607&radic&radic&radic&radic S000003306SMD1YGR074WverifiedCore Sm protein Sm D1; part of heteroheptameric complex (withSmb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D1 0.018140.32607&radic&radic S000002254OPI6YDL096CdubiousDubious open reading frame unlikely to encode a protein, basedon available experimental and comparativesequence data; partially overlaps verified genePMT1/YDL095W; YDL096C is not essential 0.01830.32607&radic&radic&radic S000005197TEX1YNL253WverifiedProtein involved in mRNA export, component of the transcriptionexport (TREX) complex 0.017690.32346&radic&radic&radic S000005732NOC2YOR206WverifiedProtein that forms a nucleolar complex with Mak21p that bindsto 90S and 66S pre-ribosomes, as well as anuclear complex with Noc3p that binds to 66Spre-ribosomes; both complexes mediateintranuclear transport of ribosomal precursors 0.017720.32346&radic&radic&radic S000003413TIM13YGR181WverifiedMitochondrial intermembrane space protein, forms a complex withTIm8p that mediates import and insertion of asubset of polytopic inner membrane proteins;may prevent aggregation of incoming proteins ina chaperone-like manner 0.017630.32346&radic&radic&radic&radic&radic S000004401UTP21YLR409CuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.017580.32308&radic&radic&radic&radic&radic S000002943YDR535CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene. 0.017580.32308&radic S000000633PHO87YCR037CverifiedLow-affinity inorganic phosphate (Pi) transporter, involved inactivation of PHO pathway; expression isindependent of Pi concentration and Pho4pactivity; contains 12 membrane-spanningsegments 0.017510.32076&radic&radic&radic S000005072TEP1YNL128WverifiedHomolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that haslipid phosphatase activity and is linked to thephosphatidylinositol signaling pathway; plays arole in normal sporulation 0.017370.32076&radic&radic&radic S000004838MRPL44YMR225CverifiedMitochondrial ribosomal protein of the large subunit 0.017430.32076&radic&radic&radic&radic&radic&radic S000004021YLR031WUncharacterizedHypothetical protein 0.017450.32076&radic&radic S000000402TAF5YBR198CverifiedSubunit (90 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification 0.01720.31766&radic&radic&radic S000001052RPL27AYHR010WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl27Bp and has similarity to ratL27 ribosomal protein 0.017050.31766&radic&radic&radic&radic&radic&radic&radic S000002972RPN14YGL004CuncharacterizedPutative non-ATPase subunit of the 19S regulatory particle ofthe 26S proteasome; localized to the cytoplasm 0.017150.31766&radic&radic&radic&radic S000001730NTR2YKR022CverifiedEssential protein that forms a dimer with Ntr1p; also forms atrimer, with Ntr2p and the DExD/H-box RNAhelicase Prp43p, that is involved inspliceosome disassembly 0.017350.31766&radic&radic&radic&radic&radic&radic S000000183RPL23AYBL087CverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl23Bp and has similarity to E.coli L14 and rat L23 ribosomal proteins 0.016820.31616&radic&radic&radic S000002535YDR128WUncharacterizedHypothetical protein 0.016690.31427&radic&radic&radic S000002493SSS1YDR086CverifiedSubunit of the Sec61p translocation complex(Sec61p-Sss1p-Sbh1p) that forms a channel forpassage of secretory proteins through theendoplasmic reticulum membrane, and of theSsh1p complex (Ssh1p-Sbh2p-Sss1p); interactswith Ost4p and Wbp1p 0.016690.31427&radic&radic&radic&radic S000000792HPA3YEL066WverifiedD-Amino acid N-acetyltransferase, catalyzes N-acetylation ofD-amino acids through ordered bi-bi mechanismin which acetyl-CoA is first substrate boundand CoA is last product liberated; similar toHpa2p, acetylates histones weakly in vitro 0.016590.31383&radic&radic&radic&radic&radic S000000825PRO3YER023WverifiedDelta 1-pyrroline-5-carboxylate reductase, catalyzes the laststep in proline biosynthesis 0.016550.31278&radic&radic S000000883SER3YER081Wverified3-phosphoglycerate dehydrogenase, catalyzes the first step inserine and glycine biosynthesis; isozyme ofSer33p 0.016490.31278&radic&radic&radic&radic&radic&radic S000006072PRP46YPL151CverifiedSplicing factor that is found in the Cef1p subcomplex of thespliceosome 0.016330.31017&radic&radic&radic&radic S000003491YGR259CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W 0.016310.31017&radic&radic&radic&radic&radic&radic&radic S000006341RRP9YPR137WverifiedProtein involved in pre-rRNA processing, associated with U3snRNP; component of small ribosomal subunit(SSU) processosome; ortholog of the humanU3-55k protein 0.016170.30861&radic&radic S000006384AOS1YPR180WverifiedNuclear protein that acts as a heterodimer with Uba2p toactivate Smt3p (SUMO) before its conjugation toproteins (sumoylation), which may play a rolein protein targeting; essential for viability 0.015990.3056&radic&radic&radic&radic&radic&radic S000002473YDR066CUncharacterizedHypothetical protein 0.015920.3056&radic&radic&radic&radic&radic S000000438ARC40YBR234CverifiedEssential subunit of the ARP2/3 complex, which is required forthe motility and integrity of cortical actinpatches 0.015920.3056&radic&radic&radic&radic&radic&radic S000002251PMT5YDL093WverifiedProtein O-mannosyltransferase, transfers mannose residues fromdolichyl phosphate-D-mannose to proteinserine/threonine residues; acts in a complexwith Pmt3p, can instead interact with Pmt2p insome conditions; target for new antifungals 0.015880.3056&radic&radic&radic S000001586LAP4YKL103CverifiedVacuolar aminopeptidase, often used as a marker protein instudies of autophagy and cytosol to vacuoletargeting (CVT) pathway 0.015740.30353&radic&radic S000006047NAN1YPL126WverifiedU3 snoRNP protein, component of the small (ribosomal) subunit(SSU) processosome containing U3 snoRNA;required for the biogenesis of18S rRNA 0.015820.30353&radic&radic&radic S000004749YMR141CDubiousHypothetical protein 0.015730.30353&radic&radic&radic&radic S000002790RPP2BYDR382WverifiedRibosomal protein P2 beta, a component of the ribosomal stalk,which is involved in the interaction betweentranslational elongation factors and theribosome; regulates the accumulation of P1(Rpp1Ap and Rpp1Bp) in the cytoplasm 0.015320.3002&radic&radic S000004009PSR2YLR019WverifiedFunctionally redundant Psr1p homolog, a plasma membranephosphatase involved in the general stressresponse; required with Psr1p and Whi2p forfull activation of STRE-mediated geneexpression, possibly through dephosphorylationof Msn2p 0.015450.3002&radic&radic&radic&radic&radic S000002537FIN1YDR130CverifiedSpindle pole body-related intermediate filament protein, formscell cycle-specific filaments between spindlepole bodies in mother and daughter cells, ableto self-assemble, expression induced duringS/G2, localization cell-cycle dependent 0.015410.3002&radic&radic&radic&radic&radic&radic&radic&radic&radic S000000470SLM6YBR266CdubiousProtein with a potential role in actin cytoskeletonorganization; gene exhibits synthetic geneticinteraction with MSS4 encodingphosphatidylinositol 4-phosphate kinase 0.015190.29715&radic&radic S000002772CDC40YDR364CverifiedPre-mRNA splicing factor, important for catalytic step II ofpre-mRNA splicing and plays a role in cellcycle progression; required for DNA synthesisduring mitosis and meiosis; has WD repeats 0.015050.29715&radic&radic&radic&radic&radic S000001780SIS2YKR072CverifiedNegative regulatory subunit of the protein phosphatase 1 Ppz1p;involved in ion homeostasis and cell cycleprogression 0.015040.29715&radic&radic&radic&radic&radic S000002971CDH1YGL003CverifiedCell-cycle regulated activator of the anaphase-promotingcomplex/cyclosome (APC/C), which directsubiquitination of mitotic cyclins resulting inexit from mitosis; targets the APC/C tospecific substrates including CDC20, ASE1 andCIN8 0.014870.29539&radic&radic S000001643ELF1YKL160WverifiedTranscription elongation factor that contains a conserved zincfinger domain; implicated in the maintenance ofproper chromatin structure in activelytranscribed regions; deletion inhibits Bromemosaic virus (BMV) gene expression 0.014830.29527&radic&radic&radic&radic&radic&radic&radic S000003623TRL1YJL087CverifiedtRNA ligase, required for tRNA splicing; composed of threeessential domains containing thephosphodiesterase, polynucleotide kinase, andligase activities required for ligation;localized at the inner membrane of the nuclearenvelope 0.014770.29441&radic&radic&radic S000000798RMD6YEL072WverifiedProtein required for sporulation 0.014690.29261&radic&radic&radic&radic S000005415PSH1YOL054WuncharacterizedNuclear protein, putative RNA polymerase II elongation factor;isolated as Pob3p/Spt16p-binding protein 0.014660.29261&radic&radic&radic&radic&radic S000005171JJJ1YNL227CverifiedProtein that contains a 70 amino acid J-domain, may function asa co-chaperone to recruit Hsp70-like activityto specific sites; mutation causes defects influid-phase endocytosis 0.014630.29261&radic&radic&radic&radic&radic S000000001TFC3YAL001CverifiedLargest of six subunits of the RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part of theTauB domain of TFIIIC that binds DNA at theBoxB promoter sites of tRNA and similar genes;cooperates with Tfc6p in DNA binding 0.014750.29261&radic&radic&radic&radic&radic&radic&radic&radic&radic S000005564HIR2YOR038CverifiedNon-essential transcriptional corepressor involved in the cellcycle-regulated transcription of histone H2A,H2B, H3, and H4 genes; recruits Swi-Snfcomplexes to histone gene promoters; promotesheterochromatic gene silencing with Asf1p 0.014610.29259&radic&radic&radic&radic&radic S000000015PSK1YAL017WverifiedOne of two (see also PSK2) PAS domain containing S/T proteinkinases; coordinately regulates proteinsynthesis and carbohydrate metabolism andstorage in response to a unknown metabolitethat reflects nutritional status 0.014530.28925&radic&radic&radic S000000441PRP5YBR237WverifiedRNA helicase in the DEAD-box family, necessary forprespliceosome formation, bridges U1 and U2snRNPs and enables stable U2 snRNP associationwith intron RNA 0.014470.28925&radic&radic&radic&radic&radic S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling 0.014240.28728&radic&radic&radic&radic&radic&radic&radic S000000472MRPL37YBR268WverifiedMitochondrial ribosomal protein of the large subunit 0.013970.28429&radic&radic&radic&radic S000002506BMH2YDR099Wverified14-3-3 protein, minor isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others 0.013960.28429&radic&radic&radic&radic&radic S000000288MIS1YBR084WverifiedMitochondrial C1-tetrahydrofolate synthase, involved ininterconversion between different oxidationstates of tetrahydrofolate (THF); providesactivities of formyl-THF synthetase,methenyl-THF cyclohydrolase, and methylene-THFdehydrogenase 0.013970.28429 S000002776YPR1YDR368Wverified2-methylbutyraldehyde reductase, may be involved in isoleucinecatabolism 0.013920.28429&radic&radic&radic&radic&radic S000000406CDC47YBR202WverifiedComponent of the hexameric MCM complex, which is important forpriming origins of DNA replication in G1 andbecomes an active ATP-dependent helicase thatpromotes DNA melting and elongation whenactivated by Cdc7p-Dbf4p in S-phase 0.013710.28107&radic&radic&radic&radic&radic&radic&radic S000004279MEC3YLR288CverifiedDNA damage and meiotic pachytene checkpoint protein; subunit ofa heterotrimeric complex (Rad17p-Mec3p-Ddc1p)that forms a sliding clamp, loaded onto partialduplex DNA by a clamp loader complex; homologof human and S. pombe Hus1 0.01380.28107&radic&radic&radic&radic&radic&radic S000001305CBR1YIL043CverifiedMicrosomal cytochrome b reductase, not essential for viability;also detected in mitochondria; mutation inconserved NADH binding domain of the humanortholog results in type I methemoglobinemia 0.013780.28107&radic&radic&radic&radic S000003199YGL230CUncharacterizedHypothetical protein 0.013720.28107&radic&radic&radic&radic&radic&radic S000004868GFD1YMR255WverifiedCoiled-coiled protein of unknown function, identified as ahigh-copy suppressor of a dbp5 mutation 0.013440.27697&radic&radic&radic&radic&radic&radic S000003181SKI8YGL213CverifiedProtein involved in exosome mediated 3' to 5' mRNA degradationand translation inhibition of non-poly(A) mRNAsas well as double-strand break formation duringmeiotic recombination; required for repressingpropagation of dsRNA viruses 0.013420.27697&radic&radic&radic&radic S000006393SKI3YPR189WverifiedProtein involved in exosome mediated 3' to 5' mRNA degradationand translation inhibition of non-poly(A)mRNAs; forms complex with Ski2p and Ski8p;required for repressing propagation of dsRNAviruses 0.013250.2764&radic&radic&radic&radic&radic&radic&radic S000002580ARG82YDR173CverifiedInositol polyphosphate multikinase (IPMK), sequentiallyphosphorylates Ins(1,4,5)P3 to formIns(1,3,4,5,6)P5; putative nuclear lipidinositol PI3-kinase; regulates arginine-,phosphate-, and nitrogen-responsive genes 0.013160.27549&radic&radic&radic&radic S000004759YIM2YMR151WdubiousDubious open reading frame, unlikely to encode a protein; notconserved in closely related Saccharomycesspecies; 5% of ORF overlaps the verified geneIMP1 0.013190.27549&radic&radic&radic S000001597APN1YKL114CverifiedMajor apurinic/apyrimidinic endonuclease, 3'-repair diesteraseinvolved in repair of DNA damage by oxidationand alkylating agents; also functions as a3'-5' exonuclease to repair7,8-dihydro-8-oxodeoxyguanosine 0.013130.27519&radic&radic&radic&radic&radic&radic&radic S000001142YHR100CUncharacterizedPutative protein of unknown function; exhibits growth defect on a non-fermentable (respiratory) carbon source; YHR100C is not an essential gene 0.01310.27483&radic&radic&radic S000004867YMR254CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data 0.012970.27334&radic&radic&radic&radic&radic S000004186PWP1YLR196WverifiedProtein with WD-40 repeats involved in rRNA processing;associates with trans-acting ribosomebiogenesis factors; similar to beta-transducinsuperfamily 0.012720.26994&radic&radic S000002787RGA2YDR379WverifiedGTPase-activating protein for the polarity-establishmentprotein Cdc42p; implicated in control of septinorganization, pheromone response, and haploidinvasive growth 0.012710.26994&radic&radic&radic S000005725YOR199WDubiousHypothetical protein 0.012620.26917&radic&radic&radic&radic S000001604YKL121WUncharacterizedPutative protein of unknown function 0.012240.26492&radic&radic S000005354YNR071CUncharacterizedHypothetical protein 0.012460.26492&radic&radic S000005606DIA2YOR080WverifiedOrigin-binding F-box protein that forms an SCF ubiquitin ligasecomplex with Skp1p and Cdc53p; plays a role inDNA replication, involved in invasive andpseudohyphal growth 0.012480.26492&radic&radic S000000905SSA4YER103WverifiedHeat shock protein that is highly induced upon stress; plays arole in SRP-dependent cotranslationalprotein-membrane targeting and translocation;member of the HSP70 family; cytoplasmic proteinthat concentrates in nuclei upon starvation 0.012430.26492&radic S000003337VMA21YGR105WverifiedIntegral membrane protein that is required for vacuolarH+-ATPase (V-ATPase) function, although not anactual component of the V-ATPase complex;functions in the assembly of the V-ATPase;localized to the yeast endoplasmic reticulum(ER) 0.01250.26492&radic&radic&radic&radic S000005126IPI3YNL182CuncharacterizedProtein required for cell viability; computational analysis oflarge-scale protein-protein interaction datasuggests a possible role in assembly of theribosomal large subunit 0.012150.26458&radic&radic&radic&radic S000002611YDR203WDubiousHypothetical protein 0.012010.26147&radic&radic&radic&radic&radic&radic S000005458YOL098CUncharacterizedPutative metalloprotease 0.012140.26147&radic S000002330GLT1YDL171CverifiedNAD(+)-dependent glutamate synthase (GOGAT), synthesizesglutamate from glutamine andalpha-ketoglutarate; with Gln1p, forms thesecondary pathway for glutamate biosynthesisfrom ammonia; expression regulated by nitrogensource 0.012080.26147 S000005355HXT17YNR072WverifiedHexose transporter, up-regulated in media containing raffinoseand galactose at pH 7.7 versus pH 4.7,repressed by high levels of glucose 0.012140.26147&radic&radic S000006345KAR3YPR141CverifiedMinus-end-directed microtubule motor that functions in mitosisand meiosis, localizes to the spindle pole bodyand localization is dependent on functionalCik1p, required for nuclear fusion duringmating; potential Cdc28p substrate 0.012140.26147&radic&radic&radic&radic&radic&radic&radic S000004758IMP1YMR150CverifiedCatalytic subunit of the mitochondrial inner membrane peptidasecomplex, required for maturation ofmitochondrial proteins of the intermembranespace; complex contains Imp1p and Imp2p (bothcatalytic subunits), and Som1p 0.0120.26147&radic&radic&radic&radic&radic&radic&radic S000000544GID7YCL039WverifiedProtein of unknown function, involved in proteasome-dependentcatabolite inactivation offructose-1,6-bisphosphatase; contains six WD40repeats; computational analysis suggests thatGid7p and Moh1p have similar functions 0.012030.26147&radic&radic&radic&radic S000004389AFG2YLR397CverifiedATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexamericcomplex; may be involved in degradation ofaberrant mRNAs 0.012110.26147&radic&radic&radic&radic&radic&radic S000005784HNT3YOR258WverifiedMember of the third branch of the histidine triad (HIT)superfamily of nucleotide-binding proteins;similar to Aprataxin, a Hint related proteinthat is mutated in individuals with ataxia withoculomotor apraxia 0.011920.26066&radic&radic&radic&radic&radic&radic S000000307SIF2YBR103WverifiedWD40 repeat-containing subunit of the Set3C histone deacetylasecomplex, which represses early/middlesporulation genes; antagonizes telomericsilencing; binds specifically to the Sir4pN-terminus 0.011870.26042&radic&radic&radic S000004652ERB1YMR049CverifiedProtein required for maturation of the 25S and 5.8S ribosomalRNAs; constituent of 66S pre-ribosomalparticles; homologous to mammalian Bop1 0.011780.2592&radic S000006021ATG21YPL100WverifiedPhosphatidylinositol 3,5-bisphosphate-binding protein requiredfor maturation of pro-aminopeptidase I,predicted to fold as a seven-bladedbeta-propeller; displays punctate cytoplasmiclocalization 0.011790.2592&radic&radic&radic S000004300IMH1YLR309CverifiedProtein involved in vesicular transport, mediates transportbetween an endosomal compartment and the Golgi,contains a Golgi-localization (GRIP) domainthat interacts with activated Arl1p-GTP tolocalize Imh1p to the Golgi 0.011630.25625&radic&radic&radic&radic&radic&radic S000002810DIT2YDR402CverifiedN-formyltyrosine oxidase, sporulation-specific microsomalenzyme required for spore wall maturation,involved in the production of a solubleLL-dityrosine-containing precursor of the sporewall, homologous to cytochrome P-450s 0.011630.25625&radic&radic&radic S000001578YJU2YKL095WverifiedEssential nuclear protein; putative spliceosomal componentinvolved in mRNA splicing, based oncomputational analysis of large-scaleprotein-protein interaction data 0.011550.25615&radic&radic&radic S000003335NOP7YGR103WverifiedNucleolar protein involved in rRNA processing and 60S ribosomalsubunit biogenesis; constituent of severaldifferent pre-ribosomal particles; required forexit from G0 and the initiation ofcell proliferation 0.011470.25513&radic&radic&radic&radic S000002656YDR248CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.011490.25513&radic&radic&radic&radic&radic&radic S000000745MMS21YEL019CverifiedSUMO ligase involved in chromosomal organization and DNArepair; essential subunit of theMms21-Smc5-Smc6 complex; mutants are sensitiveto methyl methanesulfonate and show increasedspontaneous mutation and mitotic recombination 0.011450.25513&radic&radic&radic&radic&radic&radic S000000174ATG8YBL078CverifiedProtein required for autophagy; modified by the serial actionof Atg4p, Atg7p, and Atg3p, and conjugated atthe C terminus with phosphatidylethanolamine,to become the form essential for generation ofautophagosomes 0.011490.25513&radic&radic&radic S000004760YIM1YMR152WverifiedProtein of unknown function; null mutant displays sensitivityto DNA damaging agents; the authentic,non-tagged protein is detected in highlypurified mitochondria in high-throughputstudies 0.011410.25452&radic&radic&radic&radic&radic&radic S000003212TAD1YGL243WverifiedtRNA-specific adenosine deaminase, deaminates adenosine-37 toinosine in tRNA-Ala 0.011290.25117&radic&radic&radic&radic S000001885CDC4YFL009WverifiedF-box protein required for G1/S and G2/M transition, associateswith Skp1p and Cdc53p to form a complex,SCFCdc4, which acts as ubiquitin-protein ligasedirecting ubiquitination of the phosphorylatedCDK inhibitor Sic1p 0.011380.25117&radic&radic S000000231YBR027CDubiousHypothetical protein 0.011280.25117&radic&radic&radic S000002831CAD1YDR423CverifiedAP-1-like bZIP transcriptional activator involved in multiplestress responses, iron metabolism, andpleiotropic drug resistance; controls a set ofgenes involved in stabilizing proteins, bindsconsensus sequence TTACTAA; 5' UTR containsuORFs 0.011210.25117&radic&radic&radic&radic&radic&radic S000003955YLL032CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene 0.011320.25117&radic&radic&radic&radic S000002814PDR15YDR406WverifiedATP binding cassette (ABC) transporter of the plasma membrane;general stress response factor implicated incellular detoxification; target of Pdr1p, Pdr3pand Pdr8p transcription regulators; promotercontains a PDR responsive element 0.011380.25117&radic&radic&radic&radic&radic S000002549PEX7YDR142CverifiedPeroxisomal signal receptor for the N-terminal nonapeptidesignal (PTS2) of peroxisomal matrix proteins;WD repeat protein; defects in human homologcause lethal rhizomelic chondrodysplasiapunctata (RCDP) 0.011310.25117&radic&radic S000001602VPH2YKL119CverifiedIntegral membrane protein required for vacuolar H+-ATPase(V-ATPase) function, although not an actualcomponent of the V-ATPase complex; functions inthe assembly of the V-ATPase; localized to theendoplasmic reticulum (ER) 0.011150.25067&radic&radic&radic&radic S000006160YAR1YPL239WverifiedCytoplasmic ankyrin-repeat containing protein of unknownfunction, proposed to link the processes of 40Sribosomal subunit biogenesis and adaptation toosmotic and oxidative stress; expressionrepressed by heat shock 0.011130.25067&radic&radic&radic&radic&radic&radic S000004212UTP13YLR222CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.01110.24916&radic&radic&radic S000002653MNN10YDR245WverifiedSubunit of a Golgi mannosyltransferase complex also containingAnp1p, Mnn9p, Mnn11p, and Hoc1p that mediateselongation of the polysaccharide mannanbackbone; membrane protein of themannosyltransferase family 0.010980.24793&radic&radic&radic S000003504YGR272CUncharacterizedPutative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 0.010990.24793&radic&radic&radic&radic&radic S000006376YPR172WUncharacterizedProtein of unknown function, transcriptionally activated by Yrm1p along with genes involved in multidrug resistance 0.01080.24542&radic&radic&radic&radic&radic&radic S000002665SET7YDR257CverifiedNuclear protein that contains a SET-domain, which have beenshown to mediate methyltransferase activity inother proteins 0.010730.24488&radic&radic&radic&radic&radic S000000683YCR087WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene 0.010630.24336&radic&radic&radic S000006256NHP6AYPR052CverifiedHigh-mobility group non-histone chromatin protein, functionallyredundant with Nhp6Bp; homologous to mammalianhigh mobility group proteins 1 and 2; acts torecruit transcription factor Rcs1p to certainpromoters 0.010510.24139&radic&radic&radic S000003193VRG4YGL225WverifiedGolgi GDP-mannose transporter; regulates Golgi function andglycosylation in Golgi 0.01060.24139&radic&radic&radic S000003295SPT4YGR063CverifiedProtein that forms a complex with Spt5p and mediates bothactivation and inhibition of transcriptionelongation, and plays a role in pre-mRNAprocessing; in addition, Spt4p is involved inkinetochore function and gene silencing 0.010560.24139&radic S000005205ORC5YNL261WverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing 0.010490.24139&radic&radic&radic&radic S000005895RAD17YOR368WverifiedCheckpoint protein, involved in the activation of the DNAdamage and meiotic pachytene checkpoints; withMec3p and Ddc1p, forms a clamp that is loadedonto partial duplex DNA; homolog of human andS. pombe Rad1 and U. maydis Rec1 proteins 0.010490.24139&radic&radic&radic&radic&radic S000006161HSP82YPL240CverifiedCytoplasmic chaperone (Hsp90 family) required for pheromonesignaling and negative regulation of Hsf1p;docks with the mitochondrial import receptorTom70p for preprotein delivery; interacts withco-chaperones Cns1p, Cpr6p, Cpr7p, and Sti1p 0.010370.23964&radic&radic&radic&radic&radic&radic S000000935GLC7YER133WverifiedCatalytic subunit of type 1 serine/threonine proteinphosphatase, involved in many processesincluding glycogen metabolism, sporulation, andmitosis; interacts with multiple regulatorysubunits; predominantly isolated with Sds22p 0.010350.23964&radic&radic&radic&radic S000003783LSM8YJR022WverifiedLsm (Like Sm) protein; forms heteroheptameric complex (withLsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p)that is part of spliceosomal U6 snRNP and isalso implicated in processing of pre-tRNA,pre-snoRNA, and pre-rRNA 0.01040.23964&radic&radic&radic&radic S000003750HXT8YJL214WverifiedProtein of unknown function with similarity to hexosetransporter family members, expression isinduced by low levels of glucose and repressedby high levels of glucose 0.010360.23964&radic&radic&radic&radic S000000731VAB2YEL005CverifiedProtein with a potential role in vacuolar function, assuggested by its ability to bind Vac8p; greenfluorescent protein (GFP)-fusion proteinlocalizes to the cytoplasm in a punctatepattern 0.010330.23916&radic&radic&radic S000003100YGL132WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C 0.010320.23911&radic&radic S000003749YJL213WUncharacterizedPutative protein of unknown function; periodically expressed during the yeast metabolic cycle; expression induced in respiratory incompetent petite cells; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p 0.01030.23875&radic&radic S000002483RAD55YDR076WverifiedProtein that stimulates strand exchange by stabilizing thebinding of Rad51p to single-stranded DNA;involved in the recombinational repair ofdouble-strand breaks in DNA during vegetativegrowth and meiosis; forms heterodimer withRad57p 0.01030.23875&radic&radic&radic&radic&radic&radic&radic&radic S000001566YKL083WDubiousDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14 0.010250.23807&radic&radic&radic&radic S000003605UTP18YJL069CuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.010250.23807 S000004559GIM5YML094WverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.010130.23472&radic&radic&radic S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.010150.23472&radic&radic&radic&radic&radic&radic&radic S000005731FMP38YOR205CuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.010050.23472&radic&radic&radic&radic S000004305SPH1YLR313CverifiedProtein involved in shmoo formation and bipolar bud siteselection; homologous to Spa2p, localizes tosites of polarized growth in a cell cycledependent- and Spa2p-dependent manner,interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p 0.010060.23472&radic&radic&radic&radic S000002838CYM1YDR430CverifiedLysine-specific metalloprotease of the mitochondrialintermembrane space, member of the pitrilysinfamily; degrades proteins and presequencepeptides cleaved from imported proteins;required for normal mitochondrial morphology 0.010090.23472&radic&radic&radic&radic&radic&radic S000004824DML1YMR211WverifiedEssential protein involved in mtDNA inheritance, may alsofunction in the partitioning of themitochondrial organelle or in the segregationof chromosomes, exhibits regions similar tomembers of a GTPase family 0.010010.23407&radic&radic&radic S000000462SHG1YBR258CverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres &radic0.010020.23407&radic&radic&radic&radic&radic&radic&radic S000006104YPL183CUncharacterizedHypothetical protein 0.009970.23286&radic S000004497SRC1YML034WverifiedProtein with a putative role in sister chromatid segregation,potentially phosphorylated by Cdc28p; greenfluorescent protein (GFP)-fusion proteinlocalizes to the nuclear periphery 0.009920.23286&radic&radic&radic&radic S000000173YBL077WDubiousHypothetical protein; open reading frame overlaps 3' end of essential ILS1 gene encoding cytoplasmic isoleucine-tRNA synthetase 0.009940.23286&radic&radic&radic&radic S000000230ETR1YBR026Cverified2-enoyl thioester reductase, member of the medium chaindehydrogenase/reductase family; localized to inmitochondria, where it has a probable role infatty acid synthesis 0.009910.23225&radic&radic&radic S000002284CDC48YDL126CverifiedATPase in ER, nuclear membrane and cytosol with homology tomammalian p97; in a complex with Npl4p andUfd1p participates in retrotranslocation ofubiquitinated proteins from the ER into thecytosol for degradation by the proteasome 0.00990.23225&radic&radic S000003162HOS2YGL194CverifiedHistone deacetylase required for gene activation via specificdeacetylation of lysines in H3 and H4 histonetails; subunit of the Set3 complex, ameiotic-specific repressor of sporulationspecific genes that contains deacetylaseactivity 0.00980.23051&radic&radic&radic&radic&radic S000000815PRP22YER013WverifiedDEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase,associates with lariat intermediates before thesecond catalytic step of splicing; mediatesATP-dependent mRNA release from the spliceosomeand unwinds RNA duplexes 0.009850.23051&radic&radic&radic&radic&radic&radic S000002993PGD1YGL025CverifiedSubunit of the Mediator global transcriptional cofactorcomplex, which is part of the RNA polymerase IIholoenzyme and plays an essential role in basaland activated transcription; direct target ofthe Cyc8p-Tup1p transcriptional corepressor 0.009650.22804&radic&radic&radic S000000149YBL053WDubiousHypothetical protein 0.009780.22804&radic&radic&radic&radic S000002218TSR1YDL060WverifiedProtein required for processing of 20S pre-rRNA in thecytoplasm, associates with pre-40S ribosomalparticles 0.009790.22804&radic&radic S000003231YGL262WUncharacterizedPutative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene 0.009740.22804&radic&radic&radic&radic&radic S000002811DIT1YDR403WverifiedSporulation-specific enzyme required for spore wall maturation,involved in the production of a solubleLL-dityrosine-containing precursor of the sporewall; transcripts accumulate at the time ofprospore enclosure 0.009710.22804&radic&radic&radic&radic&radic S000002494RRP1YDR087CverifiedEssential evolutionarily conserved nucleolar protein necessaryfor biogenesis of 60S ribosomal subunits andprocessing of pre-rRNAs to mature rRNAs,associated with several distinct 66Spre-ribosomal particles 0.009780.22804&radic&radic&radic&radic&radic S000005593ALG8YOR067CverifiedGlucosyl transferase, involved in N-linked glycosylation; addsglucose to the dolichol-linked oligosaccharideprecursor prior to transfer to protein duringlipid-linked oligosaccharide biosynthesis;similar to Alg6p 0.009790.22804&radic&radic&radic S000000912KAP123YER110CverifiedKaryopherin beta, mediates nuclear import of ribosomal proteinsprior to assembly into ribosomes and import ofhistones H3 and H4; localizes to the nuclearpore, nucleus, and cytoplasm; exhibits geneticinteractions with RAI1 0.009670.22804&radic&radic S000004887RCE1YMR274CverifiedType II CAAX prenyl protease involved in the proteolysis andmaturation of Ras and the a-factor matingpheromone 0.009750.22804&radic&radic&radic&radic S000000069BUD14YAR014CverifiedProtein involved in bud-site selection, Bud14p-Glc7p complexfunctions as a cortical regulator of dynein;diploid mutants display a random buddingpattern instead of the wild-type bipolarpattern 0.009610.22698&radic&radic&radic&radic&radic&radic&radic S000001220YHR177WUncharacterized 0.00960.22698&radic&radic&radic&radic S000005604BUD21YOR078WverifiedComponent of small ribosomal subunit (SSU) processosome thatcontains U3 snoRNA; originally isolated asbud-site selection mutant that displays arandom budding pattern 0.00960.22698&radic&radic S000000217YBR013CUncharacterizedHypothetical protein 0.009610.22698&radic S000003723SWE1YJL187CverifiedProtein kinase that regulates the G2/M transition by inhibitionof Cdc28p kinase activity; localizes to thenucleus and to the daughter side of themother-bud neck; homolog of S. pombe Wee1p;potential Cdc28p substrate 0.009590.22698&radic&radic&radic S000005439YOL079WDubiousHypothetical protein 0.009590.22698&radic&radic&radic&radic S000004421CRN1YLR429WverifiedCoronin, cortical actin cytoskeletal component that associateswith the Arp2p/Arp3p complex to regulate itsactivity 0.009610.22698 S000002721PIB1YDR313CverifiedRING-type ubiquitin ligase of the endosomal and vacuolarmembranes, bindsphosphatidylinositol(3)-phosphate; contains aFYVE finger domain 0.009560.22678&radic&radic&radic S000004314VPS65YLR322WdubiousDubious open reading frame, unlikely to encode a protein; notconserved in closely related Saccharomycesspecies; 75% of ORF overlaps the verified geneSFH1; deletion causes a vacuolar proteinsorting defect 0.009520.22571&radic&radic&radic&radic&radic&radic S000002835RPN9YDR427WverifiedNon-ATPase regulatory subunit of the 26S proteasome, hassimilarity to putative proteasomal subunits inother species; null mutant is temperaturesensitive and exhibits cell cycle andproteasome assembly defects 0.009510.22571&radic&radic&radic&radic S000002601YDR193WDubiousHypothetical protein 0.009510.22571&radic&radic&radic&radic&radic S000002603REF2YDR195WverifiedRNA-binding protein involved in the cleavage step of mRNA3'-end formation prior to polyadenylation, andin snoRNA maturation; part of holo-CPFsubcomplex APT, which associates with 3'-endsof snoRNA- and mRNA-encoding genes 0.009520.22571&radic&radic&radic S000003207CSE1YGL238WverifiedNuclear envelope protein that mediates the nuclear export ofimportin alpha (Srp1p), homolog of metazoan CASprotein, required for accurate chromosomesegregation 0.009440.22372&radic&radic&radic&radic&radic&radic S000003307PRP38YGR075CverifiedUnique component of the U4/U6.U5 tri-snRNP particle,dispensable for spliceosome assembly, butrequired for conformational changes which leadto catalytic activation of the spliceosome 0.00940.22372&radic&radic&radic&radic S000000886YER084WDubiousHypothetical protein 0.009430.22372&radic&radic&radic&radic&radic&radic S000001508PAN3YKL025CverifiedEssential subunit of the Pan2p-Pan3p poly(A)-ribonucleasecomplex, which acts to control poly(A) taillength and regulate the stoichiometry andactivity of postreplication repair complexes 0.009380.22366&radic&radic S000003308MRPL25YGR076CverifiedMitochondrial ribosomal protein of the large subunit 0.009370.22366&radic&radic&radic S000002490RRP8YDR083WverifiedNucleolar protein involved in rRNA processing, pre-rRNAcleavage at site A2; also involved in telomeremaintenance; mutation is synthetically lethalwith a gar1 mutation &radic0.009370.22348&radic&radic&radic&radic&radic&radic S000002454HEM12YDR047WverifiedUroporphyrinogen decarboxylase, catalyzes the fifth step in theheme biosynthetic pathway; localizes to boththe cytoplasm and nucleus; activity inhibitedby Cu2+, Zn2+, Fe2+, Fe3+ andsulfhydryl-specific reagents 0.009210.22059&radic&radic S000001341AIR1YIL079CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p to regulate methylationof Npl3p, which modulates Npl3p function inmRNA processing and export; has similarity toAir2p 0.009230.22059&radic&radic&radic&radic S000004410CDC73YLR418CverifiedConstituent of Paf1 complex with RNA polymerase II, Paf1p,Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinctfrom Srb-containing Pol II complexes; requiredfor expression of certain genes, modificationof some histones, and telomere maintenance 0.009210.22059&radic&radic&radic&radic&radic&radic&radic S000005890PIP2YOR363CverifiedAutoregulatory oleate-specific transcriptional activator ofperoxisome proliferation, contains Zn(2)-Cys(6)cluster domain, forms heterodimer with Oaf1p,binds oleate response elements (OREs),activates beta-oxidation genes 0.009240.22059&radic&radic&radic&radic&radic&radic S000001297CKA1YIL035CverifiedAlpha catalytic subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA2, CKB1 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.009220.22059&radic&radic&radic&radic&radic S000001906UBP6YFR010WverifiedUbiquitin-specific protease situated in the base subcomplex ofthe 26S proteasome, releases free ubiquitinfrom branched polyubiquitin chains; deletioncauses hypersensitivity to cycloheximide andother toxic compounds 0.00920.22059&radic&radic&radic&radic&radic&radic&radic S000004161YLR171WDubiousHypothetical protein 0.00930.22059&radic&radic S000001550YNK1YKL067WverifiedNucleoside diphosphate kinase, catalyzes the transfer of gammaphosphates from nucleoside triphosphates,usually ATP, to nucleoside diphosphates by amechanism that involves formation of anautophosphorylated enzyme intermediate 0.009160.2201&radic&radic&radic&radic&radic&radic S000003188YGL220WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus 0.009160.2201&radic&radic&radic&radic S000004761YMR153C-ADubiousHypothetical protein 0.009160.2201&radic&radic&radic S000001593KTI12YKL110CverifiedProtein that plays a role, with Elongator complex, inmodification of wobble nucleosides in tRNA;involved in sensitivity to G1 arrest induced byzymocin; interacts with chromatin throughoutthe genome; also interacts with Cdc19p 0.009060.21791&radic&radic&radic&radic&radic S000000445YBR241CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene 0.009090.21791&radic S000001116QNS1YHR074WverifiedGlutamine-dependent NAD(+) synthetase, essential for theformation of NAD(+) from nicotinic acid adeninedinucleotide 0.009080.21791&radic&radic&radic S000005145PSY2YNL201CverifiedPutative subunit of an evolutionarily conserved proteinphosphatase complex containing the catalyticsubunit Pph3p and the regulatory subunit Psy4p;required for cisplatin and oxaliplatinresistance; localizes to nucleus 0.009050.21791&radic&radic&radic S000003424TDH3YGR192CverifiedGlyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involvedin glycolysis and gluconeogenesis; tetramerthat catalyzes the reaction ofglyceraldehyde-3-phosphate to 1,3bis-phosphoglycerate; detected in the cytoplasmand cell-wall 0.009010.21633&radic&radic&radic&radic S000000167YBL071CDubiousHypothetical protein 0.008980.21633&radic&radic&radic&radic S000003105SEC27YGL137WverifiedEssential beta'-coat protein of the COPI coatomer, involved inER-to-Golgi and Golgi-to-ER transport; containsWD40 domains that mediate cargo selectiveinteractions; 45% sequence identity tomammalian beta'-COP 0.008910.21542&radic&radic S000002201PRP11YDL043CverifiedSubunit of the SF3a splicing factor complex, required forspliceosome assembly 0.008940.21542&radic&radic&radic S000000831SMB1YER029CverifiedCore Sm protein Sm B; part of heteroheptameric complex (withSmd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm B and Sm B' 0.008920.21542&radic&radic&radic S000002498RLI1YDR091CverifiedEssential iron-sulfur protein required for ribosome biogenesisand translation initiation; facilitates bindingof a multifactor complex (MFC) of translationinitiation factors to the small ribosomalsubunit; predicted ABC family ATPase 0.008890.21434&radic&radic&radic&radic S000002572TRM82YDR165WverifiedSubunit of a tRNA methyltransferase complex composed of Trm8pand Trm82p that catalyzes 7-methylguanosinemodification of tRNA &radic0.008860.21434&radic&radic&radic&radic&radic S000002487VPS41YDR080WverifiedVacuolar membrane protein that is a subunit of the homotypicvacuole fusion and vacuole protein sorting(HOPS) complex; essential for membrane dockingand fusion at the Golgi-to-endosome andendosome-to-vacuole stages of protein transport 0.008880.21434&radic&radic&radic S000002482PPH3YDR075WverifiedCatalytic subunit of an evolutionarily conserved proteinphosphatase complex containing Psy2p and theregulatory subunit Psy4p; required forcisplatin resistance; involved in activation ofGln3p 0.008870.21434&radic&radic&radic&radic&radic&radic S000000729GIM4YEL003WverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.00890.21434&radic&radic&radic&radic&radic&radic S000002903VPS3YDR495CverifiedCytoplasmic protein required for the sorting and processing ofsoluble vacuolar proteins, acidification of thevacuolar lumen, and assembly of the vacuolarH+-ATPase 0.008880.21434&radic&radic&radic S000000112FUS3YBL016WverifiedMitogen-activated protein kinase involved in mating pheromoneresponse; activated by phosphorylation bySte7p; provides specificity during the matingvs. filamentous growth response byphosphorylating transcriptional and cytoplasmictargets 0.008840.21371&radic&radic&radic&radic&radic&radic S000001188YHR145CDubiousHypothetical protein 0.008820.2129&radic&radic S000005006GCD10YNL062CverifiedSubunit of tRNA (1-methyladenosine) methyltransferase withGcd14p, required for the modification of theadenine at position 58 in tRNAs, especiallytRNAi-Met; first identified as a negativeregulator of GCN4 expression &radic0.008830.2129&radic&radic S000003084CDC20YGL116WverifiedCell-cycle regulated activator of anaphase-promotingcomplex/cyclosome (APC/C), which is requiredfor metaphase/anaphase transition; directsubiquitination of mitotic cyclins, Pds1p, andother anaphase inhibitors; potential Cdc28psubstrate 0.008820.2129&radic&radic&radic S000000851TPA1YER049WuncharacterizedProtein of unknown function; interacts with Sup45p (eRF1),Sup35p (eRF3) and Pab1p; has a role intranslation termination efficiency, mRNApoly(A) tail length and mRNA stability 0.008790.2128&radic&radic&radic&radic&radic&radic S000003954GPI13YLL031CverifiedER membrane localized phosphoryltransferase that addsphosphoethanolamine onto the third mannoseresidue of the glycosylphosphatidylinositol(GPI) anchor precursor; similar to human PIG-Oprotein 0.008790.2128&radic&radic&radic S000006019MGR2YPL098CuncharacterizedProtein required for growth of cells lacking the mitochondrialgenome 0.008680.21024&radic&radic&radic&radic S000004272YLR282CDubiousHypothetical protein 0.008720.21024&radic&radic&radic&radic S000000294YBR090CUncharacterizedHypothetical protein 0.008660.21024&radic&radic&radic S000003941DPS1YLL018CverifiedCytoplasmic aspartyl-tRNA synthetase, homodimeric enzyme thatcatalyzes the specific aspartylation oftRNA(Asp); class II aminoacyl tRNA synthetase;binding to its own mRNA may conferautoregulation 0.008690.21024&radic&radic&radic&radic&radic&radic&radic S000004872YMR259CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR259C is not an essential gene 0.008760.21024&radic&radic&radic&radic&radic&radic S000000216YBR012CDubiousHypothetical protein 0.008770.21024&radic S000006295YPR091CUncharacterizedHypothetical protein 0.008760.21024&radic&radic&radic S000004196ENT2YLR206WverifiedEpsin-like protein required for endocytosis and actin patchassembly and functionally redundant with Ent1p;contains clathrin-binding motif at C-terminus 0.008650.21024&radic&radic&radic&radic S000000165AST1YBL069WverifiedPeripheral membrane protein that interacts with the plasmamembrane ATPase Pma1p and has a role in itstargeting to the plasma membrane, possibly byinfluencing its incorporation into lipid rafts 0.008720.21024&radic&radic&radic&radic&radic&radic&radic S000004846YMR233WUncharacterizedProtein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; YMR233W is not an essential gene 0.008730.21024&radic&radic&radic&radic&radic&radic&radic&radic&radic S000003959PRP19YLL036CverifiedSplicing factor associated with the spliceosome; contains aU-box, a motif found in a class of ubiquitinligases 0.008560.20873&radic&radic&radic&radic&radic S000006381YPR177CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex 0.008550.20873&radic&radic&radic&radic&radic S000001744CAF4YKR036CverifiedWD40 repeat-containing protein associated with the CCR4-NOTcomplex, interacts in a Ccr4p-dependent mannerwith Ssn2p; also interacts with Fis1p, Mdv1pand Dnm1p and plays a role in mitochondrialfission 0.008550.20827&radic&radic S000002944STL1YDR536WverifiedGlycerol proton symporter of the plasma membrane, subject toglucose-induced inactivation, strongly buttransiently induced when cells are subjected toosmotic shock 0.008550.20827&radic&radic&radic S000000154SHP1YBL058WverifiedUBX (ubiquitin regulatory X) domain-containing protein thatregulates Glc7p phosphatase activity andinteracts with Cdc48p; interacts withubiquitylated proteins in vivo and is requiredfor degradation of a ubiquitylated modelsubstrate 0.008530.20827&radic&radic&radic&radic S000000653PWP2YCR057CverifiedConserved 90S pre-ribosomal component essential for properendonucleolytic cleavage of the 35 S rRNAprecursor at A0, A1, and A2 sites; containseight WD-repeats; PWP2 deletion leads todefects in cell cycle and bud morphogenesis 0.008520.20814 S000005377ESC8YOL017WverifiedProtein involved in telomeric and mating-type locus silencing,interacts with Sir2p and also interacts withthe Gal11p, which is a component of the RNA polII mediator complex 0.008490.20686&radic&radic&radic&radic&radic&radic&radic&radic&radic S000005378TLG2YOL018CverifiedSyntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1pand mediates fusion of endosome-derivedvesicles with the late Golgi; binds Vps45p,which prevents Tlg2p degradation and alsofacilitates t-SNARE complex formation 0.00850.20686&radic&radic&radic&radic&radic&radic S000000574VBA3YCL069WverifiedPermease of basic amino acids in the vacuolar membrane 0.008510.20686&radic&radic&radic&radic&radic S000001312PCL7YIL050WverifiedPho85p cyclin of the Pho80p subfamily, forms a functionalkinase complex with Pho85p which phosphorylatesMmr1p and is regulated by Pho81p; involved inglycogen metabolism, expression is cell-cycleregulated 0.008510.20686&radic&radic&radic&radic&radic&radic S000003085YGL117WUncharacterizedPutative protein of unknown function 0.008450.20662&radic&radic&radic S000005577YOR051CUncharacterizedNuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts 0.008430.20607&radic&radic&radic&radic S000003332MDR1YGR100WverifiedCytoplasmic GTPase-activating protein for Ypt/Rab transportGTPases Ypt6p, Ypt31p and Sec4p; involved inrecycling of internalized proteins andregulation of Golgi secretory function 0.008430.20607&radic&radic&radic&radic&radic S000001705YKL222CUncharacterizedPutative protein of unknown function; similar to transcriptional regulators from the zinc cluster (binuclear cluster) protein family; null mutant is sensitive to caffeine 0.008430.20607&radic&radic&radic&radic S000001494CCE1YKL011CverifiedMitochondrial cruciform cutting endonuclease, cleaves Hollidayjunctions formed during recombination ofmitochondrial DNA 0.00840.20493&radic&radic&radic S000002618YDR210WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery 0.008350.20493&radic&radic S000003086YGL118CDubiousHypothetical protein 0.008310.20466&radic&radic&radic S000000786PRB1YEL060CverifiedVacuolar proteinase B (yscB), a serine protease of thesubtilisin family; involved in proteindegradation in the vacuole and required forfull protein degradation during sporulation 0.00830.20449&radic&radic&radic S000000056BDH1YAL060WverifiedNAD-dependent (2R,3R)-2,3-butanediol dehydrogenase, azinc-containing medium-chain alcoholdehydrogenase, produces 2,3-butanediol fromacetoin during fermentation and allows using2,3-butanediol as a carbon source duringaerobic growth 0.008240.20284&radic&radic&radic&radic&radic&radic&radic S000005370RCL1YOL010WverifiedRNA terminal phosphate cyclase-like protein involved in rRNAprocessing at sites A0, A1, and A2; does notpossess detectable RNA cyclase activity 0.008250.20284&radic&radic&radic S000001215SPC97YHR172WverifiedComponent of the microtubule-nucleating Tub4p (gamma-tubulin)complex; interacts with Spc110p at the spindlepole body (SPB) inner plaque and with Spc72p atthe SPB outer plaque 0.008270.20284&radic&radic&radic&radic&radic&radic S000000057YAL061WUncharacterizedputative polyol dehydrogenase 0.008270.20284&radic&radic&radic&radic S000000229YBR025CUncharacterizedHypothetical protein 0.008260.20284&radic&radic&radic&radic S000001635GPM1YKL152CverifiedTetrameric phosphoglycerate mutase, mediates the conversion of3-phosphoglycerate to 2-phosphoglycerate duringglycolysis and the reverse reaction duringgluconeogenesis 0.008180.20226&radic&radic&radic&radic S000002732UTP4YDR324CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.008170.20192&radic&radic&radic&radic S000005475PAP2YOL115WverifiedCatalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), anuclear poly (A) polymerase complex involved inRNA quality control; catalyzes polyadenylationof unmodified tRNAs, and snoRNA and rRNAprecursors; disputed role as a DNA polymerase 0.008140.20061&radic&radic&radic S000002157NHP6BYBR089C-AverifiedHigh-mobility group non-histone chromatin protein, functionallyredundant with Nhp6Ap; homologous to mammalianhigh mobility group proteins 1 and 2; acts torecruit transcription factor Rcs1p to certainpromoters 0.008150.20061&radic&radic S000001365DPH1YIL103WverifiedProtein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p,for synthesis of diphthamide, which is amodified histidine residue of translationelongation factor 2 (Eft1p or Eft2p); may actin a complex with Dph2p and Kti11p 0.008150.20061&radic&radic&radic&radic S000004837MRE11YMR224CverifiedSubunit of a complex with Rad50p and Xrs2p (RMX complex) thatfunctions in repair of DNA double-strand breaksand in telomere stability, exhibits nucleaseactivity that appears to be required for RMXfunction; widely conserved 0.008140.20061&radic&radic&radic&radic&radic&radic&radic S000002578HSP42YDR171WverifiedSmall cytosolic stress-induced chaperone that formsbarrel-shaped oligomers and suppresses theaggregation of non-native proteins; oligomerdissociation is not required for function;involved in cytoskeleton reorganization afterheat shock 0.008150.20061&radic&radic&radic&radic&radic S000001199LIN1YHR156CverifiedNon-essential component of U5 snRNP; nuclear protein;physically interacts with Irr1p of cohesincomplex; may link together proteins involved inchromosome segregation, mRNA splicing and DNAreplication 0.008140.20061&radic&radic S000003457AMA1YGR225WverifiedActivator of meiotic anaphase promoting complex (APC/C); Cdc20pfamily member; required for initiation of sporewall assembly; required for Clb1p degradationduring meiosis 0.008080.20061&radic&radic&radic&radic&radic&radic S000001051YHR009CUncharacterizedPutative protein of unknown function; not an essential gene 0.008150.20061&radic&radic&radic&radic&radic S000002774YDR366CUncharacterizedHypothetical protein 0.007980.19915 S000004025MLH2YLR035CverifiedProtein required for DNA mismatch repair in mitosis andmeiosis; involved in the repair of mutationalintermediates; forms a complex with Pms1p andMsh1p to repair mismatched DNA 0.008010.19915&radic&radic S000001349YIL087CUncharacterizedPutative protein of unknown function; localized to mitochondria in high-throughput localization studies 0.008060.19915&radic&radic S000002930SPS2YDR522CverifiedProtein expressed during sporulation, redundant with Sps22p fororganization of the beta-glucan layer of thespore wall; S. pombe ortholog is a spore wallcomponent 0.008010.19915&radic&radic&radic S000003488GND2YGR256Wverified6-phosphogluconate dehydrogenase (decarboxylating), catalyzesan NADPH regenerating reaction in the pentosephosphate pathway; required for growth onD-glucono-delta-lactone 0.007980.19915&radic&radic&radic S000000252RPS11BYBR048WverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps11Ap and has similarity to E.coli S17 and rat S11 ribosomal proteins 0.007970.19862&radic&radic&radic S000001335SPO22YIL073CverifiedMeiosis-specific protein essential for chromosome synapsis,similar to phospholipase A2, involved incompletion of nuclear divisions during meiosis;induced early in meiosis 0.007980.19862&radic&radic&radic&radic&radic S000000451ENP1YBR247CverifiedProtein associated with U3 and U14 snoRNAs, required forpre-rRNA processing and 40S ribosomal subunitsynthesis; localized in the nucleus andconcentrated in the nucleolus 0.007980.19862&radic&radic&radic&radic S000005260PHA2YNL316CverifiedPrephenate dehydratase, catalyzes the conversion of prephanateto phenylpyruvate, which is a step in thephenylalanine biosynthesis pathway 0.007970.19862&radic&radic S000003213RTF1YGL244WverifiedSubunit of the RNA polymerase II-associated Paf1 complex;directly or indirectly regulates DNA-bindingproperties of Spt15p and relative activities ofdifferent TATA elements; involved in telomeremaintenance 0.007980.19862&radic&radic&radic&radic S000002848DOT1YDR440WverifiedNucleosomal histone H3-Lys79 methylase, associates withtranscriptionally active genes, functions ingene silencing at telomeres, most likely bydirectly modulating chromatin structure and Sirprotein localization &radic0.007940.19861&radic&radic S000002536SAC6YDR129CverifiedFimbrin, actin-bundling protein; cooperates with Scp1p(calponin/transgelin) in the organization andmaintenance of the actin cytoskeleton 0.007940.19861&radic&radic&radic&radic S000004821ERG12YMR208WverifiedMevalonate kinase, acts in the biosynthesis of isoprenoids andsterols, including ergosterol, from mevalonate 0.007920.198&radic&radic&radic&radic&radic&radic S000004871YMR258CUncharacterizedProtein of unknown function with similarity to F-box proteins; physically interacts with Skp1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR258C is not an essential gene 0.007920.198&radic&radic&radic&radic&radic&radic&radic&radic S000006132NIP7YPL211WverifiedNucleolar protein required for 60S ribosome subunit biogenesis,constituent of 66S pre-ribosomal particles;physically interacts with Nop8p and the exosomesubunit Rrp43p 0.007920.198&radic&radic&radic&radic S000005873REV1YOR346WverifiedDeoxycytidyl transferase, forms a complex with the subunits ofDNA polymerase zeta, Rev3p and Rev7p; involvedin repair of abasic sites in damaged DNA 0.007910.1972&radic&radic&radic&radic&radic&radic&radic S000000106YBL010CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles 0.00790.1972&radic&radic&radic&radic S000001128NAM8YHR086WverifiedRNA binding protein, component of the U1 snRNP protein; mutantsare defective in meiotic recombination and information of viable spores, involved in theformation of DSBs through meiosis-specificsplicing of MER2 pre-mRNA 0.007870.1972&radic&radic&radic&radic S000004008POM34YLR018CverifiedIntegral membrane protein of the nuclear pore; has an importantrole in maintaining the architecture of thepore complex 0.00790.1972&radic S000005462TPT1YOL102CverifiedtRNA 2'-phosphotransferase, catalyzes the final step in yeasttRNA splicing: the transfer of the 2'-PO(4)from the splice junction to NAD(+) to formADP-ribose 1''-2''cyclic phosphate andnicotinamide 0.007870.1972&radic&radic&radic S000002307NOP14YDL148CverifiedNucleolar protein, forms a complex with Noc4p that mediatesmaturation and nuclear export of 40S ribosomalsubunits; also present in the small subunitprocessome complex, which is required forprocessing of pre-18S rRNA 0.007850.197 S000004798HSC82YMR186WverifiedCytoplasmic chaperone of the Hsp90 family, redundant infunction and nearly identical with Hsp82p, andtogether they are essential; expressedconstitutively at 10-fold higher basal levelsthat HSP82 and induced 2-3 fold by heat shock 0.00780.19606&radic&radic&radic&radic S000005798YTM1YOR272WverifiedConstituent of 66S pre-ribosomal particles, required formaturation of the large ribosomal subunit 0.007730.19466&radic S000002198NAT1YDL040CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.007720.19466&radic&radic&radic S000002612COQ4YDR204WverifiedProtein with a role in ubiquinone (Coenzyme Q) biosynthesis,possibly functioning in stabilization of Coq7p;located on the matrix face of the mitochondrialinner membrane; component of a mitochondrialubiquinone-synthesizing complex 0.007780.19466&radic&radic&radic S000003661GCD14YJL125CverifiedSubunit of tRNA (1-methyladenosine) methyltransferase, withGcd10p, required for the modification of theadenine at position 58 in tRNAs, especiallytRNAi-Met; first identified as a negativeregulator of GCN4 expression &radic0.007710.19459&radic&radic&radic S000005511GRE2YOL151WverifiedNADPH-dependent methylglyoxal reductase (D-lactaldehydedehydrogenase); stress induced (osmotic, ionic,oxidative, heat shock and heavy metals);regulated by the HOG pathway 0.007660.19403&radic&radic&radic S000001318VHR1YIL056WuncharacterizedTranscriptional activator, required for the vitaminH-responsive element (VHRE) mediated inductionof VHT1 (Vitamin H transporter) and BIO5(biotin biosynthesis intermediate transporter)in response to low biotin concentrations 0.007660.19403&radic&radic&radic S000001734GCN3YKR026CverifiedAlpha subunit of the translation initiation factor eIF2B, theguanine-nucleotide exchange factor for eIF2;activity subsequently regulated byphosphorylated eIF2; first identified as apositive regulator of GCN4 expression 0.007650.19335&radic&radic&radic&radic&radic&radic&radic S000001544YKL061WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endosome 0.007660.19335&radic&radic&radic&radic&radic S000001897LOC1YFR001WverifiedNuclear protein involved in asymmetric localization of ASH1mRNA; binds double-stranded RNA in vitro;constituent of 66S pre-ribosomal particles 0.007660.19335&radic&radic&radic&radic S000004165CBF5YLR175WverifiedPseudouridine synthase catalytic subunit of box H/ACA smallnucleolar ribonucleoprotein particles(snoRNPs), acts on both large and small rRNAsand on snRNA U2 0.007610.19301&radic&radic&radic&radic S000001229KOG1YHR186CverifiedSubunit of TORC1, a rapamycin-sensitive complex involved ingrowth control that contains Tor1p or Tor2p,Lst8p and Tco89p; contains four HEAT repeatsand seven WD-40 repeats; may act as a scaffoldprotein to couple TOR and its effectors 0.007580.19253&radic&radic S000001108SSF1YHR066WverifiedConstituent of 66S pre-ribosomal particles, required forribosomal large subunit maturation;functionally redundant with Ssf2p; member ofthe Brix family 0.00760.19253&radic&radic&radic&radic&radic S000003664PBS2YJL128CverifiedMAP kinase kinase that plays a pivotal role in the osmosensingsignal-transduction pathway, activated undersevere osmotic stress 0.007570.19151&radic&radic S000000200YBL104CUncharacterizedHypothetical protein 0.007560.19151&radic S000005837NOP58YOR310CverifiedProtein involved in pre-rRNA processing, 18S rRNA synthesis,and snoRNA synthesis; component of the smallsubunit processome complex, which is requiredfor processing of pre-18S rRNA 0.007530.19111&radic S000002360TRM8YDL201WverifiedSubunit of a tRNA methyltransferase complex composed of Trm8pand Trm82p that catalyzes 7-methylguanosinemodification of tRNA &radic0.00750.19111&radic S000003567MAD2YJL030WverifiedComponent of the spindle-assembly checkpoint complex, whichdelays the onset of anaphase in cells withdefects in mitotic spindle assembly; forms acomplex with Mad1p 0.007510.19111&radic&radic&radic S000001347KTR7YIL085CverifiedPutative mannosyltransferase involved in protein glycosylation;member of the KRE2/MNT1 mannosyltransferasefamily 0.007490.19052&radic&radic S000006365SGV1YPR161CverifiedCyclin (Bur2p)-dependent protein kinase that functions intranscriptional regulation; phosphorylates thecarboxy-terminal domain of Rpo21p, which is thelargest subunit of RNA polymerase II; regulatedby Cak1p 0.007450.19018&radic&radic&radic S000004862GAD1YMR250WverifiedGlutamate decarboxylase, converts glutamate intogamma-aminobutyric acid (GABA) during glutamatecatabolism; involved in response to oxidativestress 0.007440.19008&radic&radic S000002834YDR426CDubiousHypothetical protein 0.007440.19008&radic&radic&radic&radic&radic&radic S000001463YIR024CUncharacterizedPutative protein of unknown function; GFP-fusion protein localizes to mitochondria and native protein copurifies with mitochondria; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect 0.007410.18924&radic&radic&radic&radic&radic&radic S000000122LSM2YBL026WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.007370.18883&radic&radic&radic&radic&radic S000000852RSM18YER050CverifiedMitochondrial ribosomal protein of the small subunit, hassimilarity to E. coli S18 ribosomal protein 0.007370.18883&radic&radic&radic&radic&radic S000002259DUN1YDL101CverifiedCell-cycle checkpoint serine-threonine kinase required for DNAdamage-induced transcription of certain targetgenes, phosphorylation of Rad55p and Sml1p, andtransient G2/M arrest after DNA damage; alsoregulates postreplicative DNA repair 0.007330.18791&radic&radic&radic S000000346MAK5YBR142WverifiedEssential nucleolar protein, putative DEAD-box RNA helicaserequired for maintenance of M1 dsRNA virus;involved in biogenesis of large (60S) ribosomalsubunits 0.007370.18791&radic&radic S000002923SLF1YDR515WverifiedRNA binding protein that associates with polysomes; proposed tobe involved in regulating mRNA translation;involved in the copper-dependent mineralizationof copper sulfide complexes on cell surface incells cultured in copper salts 0.007340.18791&radic S000006357YPR153WUncharacterizedHypothetical protein 0.007340.18791&radic&radic S000003189NIF3YGL221CverifiedProtein of unknown function, similar to Listeria monocytogenesmajor sigma factor (rpoD gene product); theauthentic, non-tagged protein is detected inhighly purified mitochondria in high-throughputstudies 0.007350.18791&radic&radic&radic&radic S000004416SPP382YLR424WverifiedEssential protein that forms a dimer with Ntr2p; also forms atrimer, with Ntr2p and Prp43p, that is involvedin spliceosome disassembly; found also in amultisubunit complex with the splicing factorClf1p; suppressor of prp38-1 mutation 0.007310.18734&radic&radic&radic S000002524TMA64YDR117CverifiedProtein of unknown function that associates with ribosomes; hasa putative RNA binding domain 0.007320.18734&radic&radic&radic&radic&radic S000006060UME1YPL139CverifiedNegative regulator of meiosis, required for repression of asubset of meiotic genes during vegetativegrowth, binding of histone deacetylase Rpd3prequired for activity, contains a NEE box and aWD repeat motif; homologous with Wtm1p, Wtm2p 0.007230.18582&radic&radic&radic&radic&radic&radic S000004140STM1YLR150WverifiedProtein that binds G4 quadruplex and purine motif triplexnucleic acid; acts with Cdc13p to maintaintelomere structure; interacts with ribosomesand subtelomeric Y' DNA; multicopy suppressorof tom1 and pop2 mutations 0.007270.18582&radic&radic&radic S000002625RAD9YDR217CverifiedDNA damage-dependent checkpoint protein, required forcell-cycle arrest in G1/S, intra-S, and G2/M;transmits checkpoint signal by activatingRad53p and Chk1p; hyperphosphorylated by Mec1pand Tel1p; potential Cdc28p substrate 0.007260.18582&radic&radic&radic&radic S000002544RGP1YDR137WverifiedSubunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) thatcatalyzes nucleotide exchange on Ypt6p 0.007260.18582&radic&radic S000004283SEC72YLR292CverifiedNon-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66pand Sec72p); with Sec61 complex, Kar2p/BiP andLhs1p forms a channel competent forSRP-dependent and post-translationalSRP-independent protein targeting and importinto the ER 0.007250.18582&radic&radic&radic&radic S000000479RIF1YBR275CverifiedProtein that binds to the Rap1p C-terminus and actssynergistically with Rif2p to help controltelomere length and establish telomericsilencing; deletion results in telomereelongation 0.007250.18582&radic&radic&radic S000003510CWC22YGR278WverifiedEssential protein, component of a complex containing Cef1p, hassimilarity to S. pombe Cwf22p; putativespliceosomal component, based on computationalanalysis of large-scale protein-proteininteraction data 0.007280.18582&radic&radic&radic&radic&radic&radic&radic S000000456DUT1YBR252WverifieddUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, therebypreventing incorporation of uracil into DNAduring replication; critical for themaintenance of genetic stability 0.007240.18582&radic&radic&radic&radic&radic&radic&radic S000002691GCN2YDR283CverifiedProtein kinase, phosphorylates the alpha-subunit of translationinitiation factor eIF2 (Sui2p) in response tostarvation; activated by uncharged tRNAs andthe Gcn1p-Gcn20p complex 0.007270.18582&radic&radic S000001333PCI8YIL071CverifiedPossible shared subunit of Cop9 signalosome (CSN) and eIF3,binds eIF3b subunit Prt1p, has possible dualfunctions in transcriptional and translationalcontrol, contains a PCI (Proteasome-COP9signalosome (CSN)-eIF3) domain 0.007250.18582&radic&radic&radic&radic&radic&radic S000006090MEX67YPL169CverifiedPoly(A)RNA binding protein involved in nuclear mRNA export,component of the nuclear pore; ortholog ofhuman TAP 0.007290.18582&radic S000006356URN1YPR152CuncharacterizedPre-mRNA splicing factor associated with the U2-U5-U6 snRNPs,the RES complex, and the Prp19-associatedcomplex (NTC); null mutation displays syntheticgenetic interactions with mutations affectingU2 snRNA and pre-mRNA splicing factors 0.007260.18582&radic&radic S000000203YBL107CUncharacterizedHypothetical protein 0.007250.18582&radic&radic S000000958YER156CUncharacterizedHypothetical protein 0.00720.18524&radic&radic&radic S000004560RAD10YML095CverifiedSingle-stranded DNA endonuclease (with Rad1p), cleavessingle-stranded DNA during nucleotide excisionrepair and double-strand break repair; subunitof Nucleotide Excision Repair Factor 1 (NEF1);homolog of human ERCC1 protein 0.007160.18431&radic&radic&radic&radic S000005097GIM3YNL153CverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.007170.18431&radic&radic&radic S000000796DSF1YEL070WuncharacterizedDeletion suppressor of mpt5 mutation 0.007140.18431 S000005685SME1YOR159CverifiedCore Sm protein Sm E; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm E 0.007170.18431&radic&radic&radic S000003011DST1YGL043WverifiedGeneral transcription elongation factor TFIIS, enables RNApolymerase II to read through blocks toelongation by stimulating cleavage of nascenttranscripts stalled at transcription arrestsites 0.007120.18406&radic&radic&radic&radic S000003303YGR071CUncharacterizedPutative protein of unknown function; deletion mutant has increased glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the nucleus 0.007120.18319&radic&radic&radic&radic&radic S000002982PUF4YGL014WverifiedMember of the PUF protein family, which is defined by thepresence of Pumilio homology domains thatconfer RNA binding activity; preferentiallybinds mRNAs encoding nucleolar ribosomalRNA-processing factors 0.007110.18319&radic&radic&radic&radic&radic&radic S000001594YKL111CDubiousDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene ABF1 0.007110.18319&radic&radic&radic&radic&radic&radic S000001556LHS1YKL073WverifiedMolecular chaperone of the endoplasmic reticulum lumen,involved in polypeptide translocation andfolding; member of the Hsp70 family; localizesto the lumen of the ER; regulated by theunfolded protein response pathway 0.007090.18319&radic&radic S000002839YDR431WDubiousHypothetical protein 0.007110.18319&radic&radic&radic S000000382YBR178WDubiousHypothetical protein 0.007080.18314&radic&radic&radic&radic&radic S000002203FAD1YDL045CverifiedFlavin adenine dinucleotide (FAD) synthetase, performs thesecond step in synthesis of FAD from riboflavin 0.007050.18264&radic&radic S000001132YNG2YHR090CverifiedSubunit of the NuA4 histone acetyltransferase complex thatacetylates histone H4 and H2A; has similarityto the human tumor suppressor ING1 0.007060.18264&radic&radic&radic S000000147PIN4YBL051CverifiedProtein involved in G2/M phase progression and response to DNAdamage, interacts with Rad53p; contains an RNArecognition motif, a nuclear localizationsignal, and several SQ/TQ cluster domains;hyperphosphorylated in response to DNA damage 0.007050.18253&radic&radic&radic&radic&radic&radic&radic S000004187SIK1YLR197WverifiedEssential evolutionarily-conserved nucleolar protein componentof the box C/D snoRNP complexes that direct2'-O-methylation of pre-rRNA during itsmaturation; overexpression causes spindleorientation defects 0.007040.18225&radic&radic&radic S000005607TGL5YOR081CverifiedTriacylglycerol lipase involved in TAG mobilization; localizesto lipid particles; potential Cdc28p substrate 0.007030.18177&radic&radic&radic S000000564KRR1YCL059CverifiedEssential nucleolar protein required for the synthesis of 18SrRNA and for the assembly of 40S ribosomalsubunit 0.007030.18177&radic&radic&radic&radic&radic S000004376IKI3YLR384CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;maintains structural integrity of Elongator;homolog of human IKAP, mutations in which causefamilial dysautonomia (FD) 0.007020.18177&radic&radic&radic&radic&radic&radic S000001359FYV10YIL097WverifiedProtein of unknown function, required for survival uponexposure to K1 killer toxin; involved inproteasome-dependent catabolite inactivation offructose-1,6-bisphosphatase; contains CTLHdomain 0.006990.18016&radic&radic&radic&radic&radic S000002940YDR532CUncharacterizedProtein of unknown function that localizes to the nuclear side of the spindle pole body and along short spindles; deletion mutants have short telomeres; forms a complex with Spc105p 0.006940.18016 S000003992NOC3YLR002CverifiedProtein that forms a nuclear complex with Noc2p that binds to66S ribosomal precursors to mediate theirintranuclear transport; also binds to chromatinto promote the association of DNA replicationfactors and replication initiation 0.006990.18016&radic&radic&radic&radic S000003957RIX7YLL034CverifiedPutative ATPase of the AAA family, required for export ofpre-ribosomal large subunits from the nucleus;distributed between the nucleolus, nucleoplasm,and nuclear periphery depending on growthconditions 0.006990.18016&radic&radic&radic&radic S000002638YDR230WDubiousHypothetical protein 0.006930.18016&radic&radic&radic S000005605ATX2YOR079CverifiedGolgi membrane protein involved in manganese homeostasis;overproduction suppresses the sod1 (copper,zinc superoxide dismutase) null mutation 0.006990.18016&radic&radic&radic&radic S000003740RCY1YJL204CverifiedF-box protein involved in recycling plasma membrane proteinsinternalized by endocytosis; localized to sitesof polarized growth 0.006910.17959&radic&radic&radic&radic&radic S000005686MTR10YOR160WverifiedNuclear import receptor, mediates the nuclear localization ofproteins involved in mRNA-nucleus export 0.006890.17933&radic&radic&radic&radic&radic&radic&radic&radic S000004267YSH1YLR277CverifiedPutative endonuclease, subunit of the mRNA cleavage andpolyadenylation specificity complex requiredfor 3' processing of mRNAs 0.006890.17933&radic&radic&radic S000003078CUE3YGL110CuncharacterizedProtein of unknown function; has a CUE domain that bindsubiquitin, which may facilitate intramolecularmonoubiquitination 0.006860.17829&radic&radic S000002545HPR1YDR138WverifiedSubunit of THO/TREX complexes that couple transcriptionelongation with mitotic recombination and withmRNA metabolism and export, subunit of an RNAPol II complex; regulates lifespan; involved intelomere maintenance; similar to Top1p 0.006860.17829&radic&radic&radic&radic&radic&radic S000004710YPK2YMR104CverifiedProtein kinase with similarityto serine/threonine proteinkinase Ypk1p; functionally redundant with YPK1at the genetic level; participates in asignaling pathway required for optimal cellwall integrity; homolog of mammalian kinase SGK 0.006870.17829&radic&radic&radic S000002546RUB1YDR139CverifiedUbiquitin-like protein with similarity to mammalian NEDD8;conjugation (neddylation) substrates includethe cullins Cdc53p, Rtt101p, and Cul3p;activated by Ula1p and Uba3p (E1 enzyme pair);conjugation mediated by Ubc12p (E2 enzyme) 0.006830.17829&radic&radic&radic&radic&radic&radic S000000221KAP104YBR017CverifiedTransportin, cytosolic karyopherin beta 2 involved in deliveryof heterogeneous nuclear ribonucleoproteins tothe nucleoplasm, binds rg-nuclear localizationsignals on Nab2p and Hrp1p, plays a role incell-cycle progression 0.006840.17829&radic&radic S000005677RPB2YOR151CverifiedRNA polymerase II second largest subunit B150, part of centralcore; similar to bacterial beta subunit 0.006830.17816&radic&radic&radic S000005888PRT1YOR361CverifiedSubunit of the core complex of translation initiation factor3(eIF3), essential for translation; part of asubcomplex (Prt1p-Rpg1p-Nip1p) that stimulatesbinding of mRNA and tRNA(i)Met to ribosomes 0.006830.17816&radic&radic S000002453BAP3YDR046CverifiedAmino acid permease involved in the uptake of cysteine,leucine, isoleucine and valine 0.006820.17791 S000005735NPT1YOR209CverifiedNicotinate phosphoribosyltransferase, acts in the salvagepathway of NAD+ biosynthesis; required forsilencing at rDNA and telomeres and has a rolein silencing at mating-type loci; localized tothe nucleus 0.006820.17791&radic&radic&radic&radic&radic S000003323PRP31YGR091WverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.006810.17791&radic&radic&radic&radic&radic S000004973YNL028WDubiousHypothetical protein 0.00680.17733&radic&radic S000001146GRE3YHR104WverifiedAldose reductase involved in methylglyoxal, d-xylose andarabinose metabolism; stress induced (osmotic,ionic, oxidative, heat shock, starvation andheavy metals); regulated by the HOG pathway 0.006810.17733&radic&radic&radic&radic&radic&radic&radic S000004955YNL010WUncharacterizedPutative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation 0.006760.17666&radic&radic&radic S000004280GUF1YLR289WverifiedMitochondrial GTPase of unknown function, similar to E. colielongation factor-type GTP-binding protein LepAand to LK1236.1 from Caenorhabditis elegans 0.006760.17666&radic&radic&radic&radic&radic S000003398KRE11YGR166WverifiedProtein involved in biosynthesis of cell wall beta-glucans;subunit of the TRAPP (transport proteinparticle) complex, which is involved in thelate steps of endoplasmic reticulum to Golgitransport 0.006780.17666&radic&radic&radic S000006347RRP15YPR143WverifiedNucleolar protein, constituent of pre-60S ribosomal particles;required for processing of the 27S pre-rRNA atthe A2 site to yield 5.8S and 25S rRNA 0.006750.17666&radic&radic&radic S000003716ATP12YJL180CverifiedConserved protein required for assembly of alpha and betasubunits into the F1 sector of mitochondrialF1F0 ATP synthase; mutation of human ATP12reduces active ATP synthase levels and isassociated with the disorder ATPAF2 deficiency 0.006720.17578&radic&radic&radic&radic&radic S000000459YBR255WUncharacterizedProtein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.006680.1752&radic&radic S000005365RPB11YOL005CverifiedRNA polymerase II subunit B12.5; part of central core; similarto Rpc19p and bacterial alpha subunit 0.006680.1752&radic&radic&radic&radic S000006272HOS1YPR068CverifiedPutative class I histone deacetylase (HDAC) with sequencesimilarity to Hda1p, Rpd3p, Hos2p, and Hos3p;deletion results in increased histoneacetylation at rDNA repeats; interacts with theTup1p-Ssn6p corepressor complex 0.006690.1752&radic&radic&radic S000003729YJL193WUncharacterizedPutative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect 0.006610.17302&radic&radic&radic&radic S000002372NOP6YDL213CuncharacterizedProtein with similarity to hydrophilins, which are involved inthe adaptive response to hyperosmoticconditions; computational analysis oflarge-scale protein-protein interaction datasuggests a possible role in rRNA processing 0.006660.17302&radic&radic S000004039YLR049CUncharacterizedHypothetical protein 0.006660.17302&radic&radic&radic&radic&radic S000000381EHT1YBR177CverifiedAcyl-coenzymeA:ethanol O-acyltransferase that plays a minorrole in medium-chain fatty acid ethyl esterbiosynthesis; contains esterase activity;localizes to lipid particles and themitochondrial outer membrane 0.006620.17302&radic&radic&radic&radic&radic S000000341YBR137WUncharacterizedProtein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); YBR137W is not an essential gene 0.006610.17302&radic&radic S000000832CHZ1YER030WuncharacterizedPutative chaperone for Htz1p/H2A-H2B dimer 0.006590.17302&radic&radic&radic&radic&radic S000001930PHO4YFR034CverifiedBasic helix-loop-helix (bHLH) transcription factor; bindscooperatively with Pho2p to the PHO5 promoter;function is regulated by phosphorylation atmultiple sites and by phosphate availability 0.006670.17302&radic&radic&radic&radic&radic S000004632RSF1YMR030WverifiedProtein required for respiratory growth; localized to both thenucleus and mitochondrion; mutant displaysdecreased transcription of specific nuclear andmitochondrial genes whose products are involvedin respiratory growth 0.006660.17302&radic&radic&radic&radic&radic&radic S000005356YNR073CUncharacterizedHypothetical protein 0.006670.17302&radic&radic S000003272KSS1YGR040WverifiedMitogen-activated protein kinase (MAPK) involved in signaltransduction pathways that control filamentousgrowth and pheromone response 0.006580.17302&radic&radic&radic&radic S000003853FIP1YJR093CverifiedSubunit of cleavage polyadenylation factor (CPF), interactsdirectly with poly(A) polymerase (Pap1p) toregulate its activity 0.006650.17302&radic&radic S000004069SIC1YLR079WverifiedInhibitor of Cdc28-Clb kinase complexes that controls G1/Sphase transition, preventing premature S phaseand ensuring genomic integrity; phosphorylationtargets Sic1p for SCF(CDC4)-dependent turnover;functional homolog of mammalian Kip1 0.006570.17263&radic&radic&radic S000002299RPO21YDL140CverifiedRNA polymerase II largest subunit B220, part of central core;phosphorylation of C-terminal heptapeptiderepeat domain regulates association withtranscription and splicing factors; similar tobacterial beta-prime 0.006570.17263&radic S000000964RAD4YER162CverifiedProtein that recognizes and binds damaged DNA (with Rad23p)during nucleotide excision repair; subunit ofNuclear Excision Repair Factor 2 (NEF2);homolog of human XPC protein 0.006550.17259&radic&radic&radic S000003440SER2YGR208WverifiedPhosphoserine phosphatase of the phosphoglycerate pathway,involved in serine and glycine biosynthesis,expression is regulated by the availablenitrogen source 0.006550.1724&radic&radic&radic&radic&radic&radic&radic&radic S000001501SWD2YKL018WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lys 4 and is involved intelomeric silencing; subunit of CPF (cleavageand polyadenylation factor), a complex involvedin RNAP II transcription termination &radic0.006550.1724&radic&radic S000004361SSQ1YLR369WverifiedMitochondrial hsp70-type molecular chaperone, required forassembly of iron/sulfur clusters into proteinsat a step after cluster synthesis, and formaturation of Yfh1p, which is a homolog ofhuman frataxin implicated in Friedreich'sataxia 0.006540.1724&radic&radic&radic&radic&radic&radic S000000187MAP2YBL091CverifiedMethionine aminopeptidase, catalyzes the cotranslationalremoval of N-terminal methionine from nascentpolypeptides; function is partially redundantwith that of Map1p 0.006510.17149&radic&radic&radic&radic&radic&radic&radic S000000975RAD24YER173WverifiedCheckpoint protein, involved in the activation of the DNAdamage and meiotic pachytene checkpoints;subunit of a clamp loader that loadsRad17p-Mec3p-Ddc1p onto DNA; homolog of humanand S. pombe Rad17 protein 0.006490.17149&radic&radic&radic S000000022LTE1YAL024CverifiedPutative GDP/GTP exchange factor required for mitotic exit atlow temperatures; acts as a guanine nucleotideexchange factor (GEF) for Tem1p, which is a keyregulator of mitotic exit; physicallyassociates with Ras2p-GTP 0.006520.17149&radic&radic&radic S000004925PSE1YMR308CverifiedKaryopherin/importin that interacts with the nuclear porecomplex; acts as the nuclear import receptorfor specific proteins, including Pdr1p, Yap1p,Ste12p, and Aft1p 0.006490.17149&radic&radic&radic S000005820RRS1YOR294WverifiedEssential protein that binds ribosomal protein L11 and isrequired for nuclear export of the 60Spre-ribosomal subunit during ribosomebiogenesis; mouse homolog shows alteredexpression in Huntington's disease model mice 0.006460.17044&radic&radic&radic&radic S000005582NOB1YOR056CverifiedEssential nuclear protein involved in proteasome maturation andsynthesis of 40S ribosomal subunits; requiredfor cleavage of the 20S pre-rRNA to generatethe mature 18S rRNA 0.006420.17009&radic&radic&radic S000002700SRP101YDR292CverifiedSignal recognition particle (SRP) receptor - alpha subunit;contain GTPase domains; involved inSRP-dependent protein targeting; interacts withSRP102p 0.006420.17009&radic&radic&radic&radic S000001561DHR2YKL078WverifiedPredominantly nucleolar DEAH-box RNA helicase, required for 18SrRNA synthesis 0.006380.16913&radic&radic S000001334HOP1YIL072WverifiedMeiosis-specific DNA binding protein that displays Red1pdependent localization to the unsynapsedaxial-lateral elements of the synaptonemalcomplex; required for homologous chromosomesynapsis and chiasma formation 0.006390.16913&radic&radic&radic&radic&radic&radic S000002796RVS167YDR388WverifiedActin-associated protein, subunit of a complex(Rvs161p-Rvs167p) involved in regulation ofactin cytoskeleton, endocytosis, and viabilityfollowing starvation or osmotic stress; homologof mammalian amphiphysin 0.006380.16913&radic&radic&radic&radic&radic S000004108YLR118CVerifiedAcyl-protein thioesterase responsible for depalmitoylation of Gpa1p; the mutant has no gross defects in signaling through the mating pathway; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 0.006390.16913&radic&radic&radic S000005030YNL086WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to endosomes 0.006380.16913&radic&radic&radic S000001081MSC7YHR039CverifiedProtein of unknown function, green fluorescent protein(GFP)-fusion protein localizes to theendoplasmic reticulum; msc7 mutants aredefective in directing meiotic recombinationevents to homologous chromatids 0.006370.16877&radic&radic&radic S000003152STR3YGL184CverifiedCystathionine beta-lyase, converts cystathionine intohomocysteine 0.006350.1685&radic&radic&radic S000001126STE12YHR084WverifiedTranscription factor that is activated by a MAP kinasesignaling cascade, activates genes involved inmating or pseudohyphal/invasive growthpathways; cooperates with Tec1p transcriptionfactor to regulate genes specific for invasivegrowth 0.006350.1685&radic S000005505CTR9YOL145CverifiedComponent of the Paf1p complex, which is a large complex thatbinds to and modulates the activity of RNApolymerase II and is required for expression ofa subset of genes, including cyclin genes;contains TPR repeats 0.006350.1685&radic&radic S000003794RAV1YJR033CverifiedSubunit of the RAVE complex (Rav1p, Rav2p, Skp1p), whichpromotes assembly of the V-ATPase holoenzyme;required for transport between the early andlate endosome/PVC and for localization of TGNmembrane proteins; potential Cdc28p substrate 0.006330.16803&radic S000002209LHP1YDL051WverifiedRNA binding protein required for maturation of tRNA and snRNAprecursors; acts as a molecular chaperone forRNAs transcribed by polymerase III; homologousto human La (SS-B) autoantigen 0.006330.16803&radic S000001939IRC6YFR043CuncharacterizedHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 0.006330.16803&radic&radic&radic&radic S000000245FAT1YBR041WverifiedFatty acid transporter and very long-chain fatty acyl-CoAsynthetase, may form a complex with Faa1p orFaa4p that imports and activates exogenousfatty acids 0.00630.16738&radic&radic S000006276NOT5YPR072WverifiedSubunit of the CCR4-NOT complex, which is a globaltranscriptional regulator with roles intranscription initiation and elongation and inmRNA degradation 0.006290.16738&radic S000000613PET18YCR020CverifiedProtein required for respiratory growth and stability of themitochondrial genome 0.006290.1666&radic&radic&radic S000005317SOL1YNR034WverifiedProtein with a possible role in tRNA export; shows similarityto 6-phosphogluconolactonase non-catalyticdomains but does not exhibit this enzymaticactivity; homologous to Sol2p, Sol3p, and Sol4p 0.006270.1666&radic&radic S000003367PRE9YGR135Wverified20S proteasome beta-type subunit; the only nonessential 20Ssubunit 0.006270.1666&radic&radic&radic&radic&radic&radic&radic S000001055ARD1YHR013CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.006270.1666&radic&radic&radic&radic&radic&radic S000005649LEO1YOR123CverifiedComponent of the Paf1 complex, which associates with RNApolymerase II and is involved in histonemethylation 0.006270.1666&radic&radic&radic&radic&radic&radic S000003214GUS1YGL245WverifiedGlutamyl-tRNA synthetase (GluRS), forms a complex withmethionyl-tRNA synthetase (Mes1p) and Arc1p;complex formation increases the catalyticefficiency of both tRNA synthetases and ensurestheir correct localization to the cytoplasm 0.006240.16627&radic&radic&radic&radic S000005504NOP8YOL144WverifiedNucleolar protein required for 60S ribosomal subunit biogenesis 0.006220.16563&radic S000002629GTB1YDR221WverifiedGlucosidase II beta subunit, forms a complex with alpha subunitRot2p, involved in removal of two glucoseresidues from N-linked glycans duringglycoprotein biogenesis in the ER 0.006210.16563&radic&radic&radic S000004239YEF3YLR249WverifiedTranslational elongation factor, stimulates the binding ofaminoacyl-tRNA (AA-tRNA) to ribosomes byreleasing EF-1 alpha from the ribosomalcomplex; contains two ABC cassettes; binds andhydrolyses ATP 0.006230.16563&radic&radic&radic&radic S000002806UTP5YDR398WverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.00620.16555&radic&radic S000000301VPS15YBR097WverifiedMyristoylated serine/threonine protein kinase involved invacuolar protein sorting; functions as amembrane-associated complex with Vps34p; activeform recruits Vps34p to the Golgi membrane;interacts with the GDP-bound form of Gpa1p 0.00620.16555&radic S000003451YGR219WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C 0.006190.16491&radic&radic&radic&radic&radic&radic S000003893NMD5YJR132WverifiedKaryopherin, a carrier protein involved in nuclear import ofproteins; importin beta homolog 0.006180.16491&radic&radic&radic&radic S000002581HMO1YDR174WverifiedChromatin associated high mobility group (HMG) family memberinvolved in genome maintenance; rDNA-bindingcomponent of the Pol I transcription system;associates with a 5'-3' DNA helicase and Fpr1p,a prolyl isomerase 0.006160.16432 S000001497URB1YKL014CverifiedNucleolar protein required for the normal accumulation of 25Sand 5.8S rRNAs, associated with the 27SA2pre-ribosomal particle; proposed to be involvedin the biogenesis of the 60S ribosomal subunit 0.006160.16432&radic S000005405PSK2YOL045WverifiedOne of two (see also PSK1) PAS domain containing S/T proteinkinases; regulates sugar flux and translationin response to an unknown metabolite byphosphorylating Ugp1p and Gsy2p (sugar flux)and Caf20p, Tif11p and Sro9p (translation) 0.006160.16432&radic&radic&radic S000001917ATG18YFR021WverifiedPhosphatidylinositol 3,5-bisphosphate-binding protein of thevacuolar membrane, predicted to fold as aseven-bladed beta-propeller; required forrecycling of Atg9p through thepre-autophagosomal structure 0.006160.16432 S000005724BFR1YOR198CverifiedComponent of mRNP complexes associated with polyribosomes;implicated in secretion and nuclearsegregation; multicopy suppressor of BFA(Brefeldin A) sensitivity 0.006150.16432&radic&radic&radic&radic&radic S000000701PAU3YCR104WverifiedPart of 23-member seripauperin multigene family encoded mainlyin subtelomeric regions, active duringalcoholic fermentation, regulated byanaerobiosis, negatively regulated by oxygen,repressed by heme 0.006140.16418&radic S000005382YOL022CUncharacterizedProtein required for cell viability 0.006140.16418&radic&radic&radic S000001283RPB3YIL021WverifiedRNA polymerase II third largest subunit B44, part of centralcore; similar to prokaryotic alpha subunit 0.006080.16123&radic&radic&radic&radic&radic S000003388PTI1YGR156WverifiedPta1p Interacting protein 0.006130.16123&radic&radic&radic S000003158CDC55YGL190CverifiedNon-essential regulatory subunit B of protein phosphatase 2A;has multiple roles in mitosis and proteinbiosynthesis; found in the nucleus of mostcells but also at the bud neck (large-buddedcells) and at the bud tip (small-budded cells) 0.006120.16123&radic&radic&radic S000002459DBF4YDR052CverifiedRegulatory subunit of Cdc7p-Dbf4p kinase complex, required forCdc7p kinase activity and initiation of DNAreplication; phosphorylates the Mcm2-7 familyof proteins; cell cycle regulated 0.006130.16123&radic&radic&radic&radic S000005779NAT5YOR253WverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.006020.16123&radic&radic S000005042RAS2YNL098CverifiedGTP-binding protein that regulates the nitrogen starvationresponse, sporulation, and filamentous growth;farnesylation and palmitoylation required foractivity and localization to plasma membrane;homolog of mammalian Ras proto-oncogenes 0.006070.16123&radic&radic S000001191IMP3YHR148WverifiedComponent of the SSU processome, which is required for pre-18SrRNA processing, essential protein thatinteracts with Mpp10p and mediates interactionsof Imp4p and Mpp10p with U3 snoRNA 0.006080.16123&radic&radic S000003348SPT6YGR116WverifiedEssential protein that interacts with histones and is involvedin nucleosome disassembly and reassembly duringtranscription elongation 0.006070.16123&radic&radic S000005682NFI1YOR156CverifiedSUMO ligase, catalyzes the covalent attachment of SUMO (Smt3p)to proteins; involved in maintenance of propertelomere length 0.006090.16123&radic&radic&radic&radic S000005151RIO2YNL207WverifiedEssential serine kinase involved in the processing of the 20Spre-rRNA into mature 18S rRNA; has similarityto Rio1p 0.00610.16123&radic&radic&radic S000001225YHR182WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm 0.006130.16123&radic&radic&radic S000004265SMD2YLR275WverifiedCore Sm protein Sm D2; part of heteroheptameric complex (withSmb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D2 0.006070.16123&radic&radic S000001292SSM4YIL030CverifiedUbiquitin-protein ligase of the ER/nuclear envelope, requiredfor degradation of Alpha2p and other proteinscontaining a Deg1 degradation signal; ssm4mutation suppresses mRNA instability caused byan rna14 mutation 0.00610.16123&radic S000003156YGL188CDubiousHypothetical protein 0.006030.16123&radic&radic S000001562SMY1YKL079WverifiedProtein that interacts with Myo2p, proposed to be involved inexocytosis; N-terminal domain is related to themotor domain of kinesins 0.006110.16123&radic&radic&radic&radic&radic S000001030CBP2YHL038CverifiedMitochondrial protein required for splicing of the group Iintron aI5 of the COB pre-mRNA, binds to theRNA to promote splicing; also involved in butnot essential for splicing of the COB bI2intron and the intron in the 21S rRNA gene 0.006120.16123&radic&radic&radic&radic&radic S000004271YLR281CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene 0.006020.16099&radic&radic&radic&radic&radic S000004046ERG3YLR056WverifiedC-5 sterol desaturase, catalyzes the introduction of a C-5(6)double bond into episterol, a precursor inergosterol biosynthesis; mutants are viable,but cannot grow on non-fermentable carbonsources 0.006010.16098&radic&radic&radic S000003026RAD6YGL058WverifiedUbiquitin-conjugating enzyme (E2), involved in postreplicationrepair (with Rad18p), sporulation, telomeresilencing, and ubiquitin-mediated N-end ruleprotein degradation (with Ubr1p) 0.0060.16031&radic&radic&radic&radic S000001558YKL075CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin 0.0060.16031&radic&radic&radic&radic&radic S000000635MATALPHA2YCR039CverifiedHomeobox-domain protein that, with Mcm1p, represses a-specificgenes in haploids; acts with A1p to represstranscription of haploid-specific genes indiploids; one of two genes encoded by theMATalpha mating type cassette 0.0060.16031&radic S000004339KAP95YLR347CverifiedKaryopherin beta, forms a dimeric complex with Srp1p (Kap60p)that mediates nuclear import of cargo proteinsvia a nuclear localization signal (NLS),interacts with nucleoporins to guide transportacross the nuclear pore complex 0.005990.16031&radic&radic&radic S000004255NEJ1YLR265CverifiedProtein involved in regulation of nonhomologous end joining;repressed by MAT heterozygosity; associateswith Lif1p and regulates its cellulardistribution 0.0060.16031&radic&radic&radic&radic&radic&radic S000002457TPI1YDR050CverifiedTriose phosphate isomerase, abundant glycolytic enzyme; mRNAhalf-life is regulated by iron availability;transcription is controlled by activatorsReb1p, Gcr1p, and Rap1p through binding sitesin the 5' non-coding region 0.0060.16031&radic&radic&radic&radic S000002922YDR514CUncharacterizedHypothetical protein 0.005980.16015&radic S000000663SED4YCR067CverifiedIntegral endoplasmic reticulum membrane protein, functions as apositive regulator of Sar1p probably throughinhibition of GTPase activation by Sec23p;binds Sec16p, participates in vesicleformation, similar to Sec12p 0.005970.15999&radic&radic S000005795PAC1YOR269WverifiedProtein involved in nuclear migration, part of thedynein/dynactin pathway; targets dynein tomicrotubule tips, which is necessary forsliding of microtubules along bud cortex;synthetic lethal with bni1; homolog of humanLIS1 0.005970.15999&radic&radic S000004732STO1YMR125WverifiedLarge subunit of the nuclear mRNA cap-binding protein complex,interacts with Npl3p to carry nuclear poly(A)+mRNA to cytoplasm; also involved in nuclearmRNA degradation and telomere maintenance;orthologous to mammalian CBP80 0.005970.15999&radic&radic&radic S000004075ARP6YLR085CverifiedActin-related protein that binds nucleosomes; a component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.005950.15958&radic&radic&radic S000004665RNA14YMR061WverifiedCleavage and polyadenylation factor I (CF I) component involvedin cleavage and polyadenylation of mRNA 3'ends; bridges interaction between Rna15p andHrp1p in the CF I complex 0.005950.15958&radic&radic S000000123RPL19BYBL027WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl19Ap and has similarity to ratL19 ribosomal protein; rpl19a and rpl19b singlenull mutations result in slow growth, while thedouble null mutation is lethal 0.005960.15958&radic&radic&radic S000003833NPA3YJR072CverifiedEssential, conserved, cytoplasmic ATPase; phosphorylated by thePcl1p-Pho85p kinase complex 0.005960.15958&radic&radic&radic S000000667IMG2YCR071CverifiedMitochondrial ribosomal protein of the small subunit 0.005960.15958&radic&radic&radic S000004735ECM16YMR128WverifiedEssential DEAH-box ATP-dependent RNA helicase specific to theU3 snoRNP, predominantly nucleolar indistribution, required for 18S rRNA synthesis 0.005950.15958&radic S000000846ERG28YER044CverifiedEndoplasmic reticulum membrane protein, may facilitateprotein-protein interactions between the Erg26pdehydrogenase and the Erg27p 3-ketoreductaseand/or tether these enzymes to the ER, alsointeracts with Erg6p 0.00590.15814&radic&radic&radic&radic S000001071YHI9YHR029CverifiedProtein of unknown function that is a member of the PhzFsuperfamily, although unlike its bacterialhomolog, is most likely not involved inphenazine production; possibly involved in amembrane regulation metabolic pathway 0.005920.15814&radic&radic S000004312MMS22YLR320WverifiedProtein involved in resistance to ionizing radiation; acts withMms1p in a repair pathway that may be involvedin resolving replication intermediates orpreventing the damage caused by blockedreplication forks 0.005910.15814&radic&radic&radic&radic S000003358YGR126WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 0.005910.15814&radic&radic&radic&radic&radic S000000323MUD1YBR119WverifiedU1 snRNP A protein, homolog of human U1-A; involved in nuclearmRNA splicing 0.005950.15814&radic&radic&radic S000000363IFA38YBR159WverifiedMicrosomal beta-keto-reductase; contains oleate responseelement (ORE) sequence in the promoter region;mutants exhibit reduced VLCFA synthesis,accumulate high levels of dihydrosphingosine,phytosphingosine and medium-chain ceramides. 0.005890.15796 S000003038RPB9YGL070CverifiedRNA polymerase II subunit B12.6; contacts DNA; mutations affecttranscription start site; involved in telomeremaintenance 0.00590.15796&radic&radic&radic&radic&radic S000004911LCB1YMR296CverifiedComponent of serine palmitoyltransferase, responsible alongwith Lcb2p for the first committed step insphingolipid synthesis, which is thecondensation of serine with palmitoyl-CoA toform 3-ketosphinganine 0.005890.15796 S000005999ATP4YPL078CverifiedSubunit b of the stator stalk of mitochondrial F1F0 ATPsynthase, which is a large, evolutionarilyconserved enzyme complex required for ATPsynthesis 0.005890.15796&radic&radic&radic&radic&radic S000002904PUF6YDR496CverifiedPumilio-homology domain protein that binds ASH1 mRNA at PUFconsensus sequences in the 3' UTR and repressesits translation, resulting in proper asymmetriclocalization of ASH1 mRNA 0.005890.15796&radic&radic S000002893VPS72YDR485CverifiedHtz1p-binding component of the SWR1 complex, which exchangeshistone variant H2AZ (Htz1p) forchromatin-bound histone H2A; required forvacuolar protein sorting 0.005890.15796&radic S000005964NOP4YPL043WverifiedNucleolar protein, essential for processing and maturation of27S pre-rRNA and large ribosomal subunitbiogenesis; constituent of 66S pre-ribosomalparticles; contains four RNA recognition motifs(RRMs) 0.005870.1576&radic&radic S000005530UTP23YOR004WverifiedEssential nucleolar protein that is a component of the SSU(small subunit) processome involved in 40Sribosomal subunit biogenesis; has homology toPINc domain protein Fcf1p, although the PINcdomain of Utp23p is not required for function 0.005860.15708&radic&radic&radic&radic S000004190YKE2YLR200WverifiedSubunit of the heterohexameric Gim/prefoldin protein complexinvolved in the folding of alpha-tubulin,beta-tubulin, and actin 0.005860.15708&radic&radic&radic S000002716SRB7YDR308CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation; target of theglobal repressor Tup1p 0.005860.15708&radic&radic&radic&radic S000006259SEC8YPR055WverifiedEssential 121kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which has the essential function ofmediating polarized targeting of secretoryvesicles to active sites of exocytosis 0.005840.15678&radic&radic&radic S000005611OST3YOR085WverifiedGamma subunit of the oligosaccharyltransferase complex of theER lumen, which catalyzes asparagine-linkedglycosylation of newly synthesized proteins;Ost3p is important for N-glycosylation of asubset of proteins 0.005830.15669&radic&radic&radic S000000330TPS1YBR126CverifiedSynthase subunit of trehalose-6-phosphate synthase/phosphatasecomplex, which synthesizes the storagecarbohydrate trehalose; also found in amonomeric form; expression is induced by thestress response and repressed by the Ras-cAMPpathway 0.005840.15669&radic&radic&radic S000002470YDR063WUncharacterizedHypothetical protein 0.005820.15631&radic&radic&radic&radic&radic S000001240RIX1YHR197WverifiedEssential protein involved in the processing of the ITS2 regionof the rRNA locus; required for the maturationand nuclear export of the 60S ribosomal subunit 0.005820.15631&radic&radic S000001924CDC14YFR028CverifiedProtein phosphatase required for mitotic exit; located in thenucleolus until liberated by the FEAR andMitotic Exit Network in anaphase, enabling itto act on key substrates to effect a decreasein CDK/B-cyclin activity and mitotic exit 0.005820.15631&radic&radic S000003931DRS1YLL008WverifiedNucleolar DEAD-box protein required for ribosome assembly andfunction, including synthesis of 60S ribosomalsubunits; constituent of 66S pre-ribosomalparticles 0.005820.15631&radic&radic&radic&radic S000005194RAD50YNL250WverifiedSubunit of MRX complex, with Mre11p and Xrs2p, involved inprocessing double-strand DNA breaks invegetative cells, initiation of meiotic DSBs,telomere maintenance, and nonhomologous endjoining 0.005790.15567&radic&radic S000002957TMA20YER007C-AverifiedProtein of unknown function that associates with ribosomes andhas a putative RNA binding domain; interactswith Tma22p; null mutant exhibits translationdefects; has homology to human oncogene MCT-1 0.005790.15567&radic&radic&radic&radic&radic&radic S000002312SAS10YDL153CverifiedComponent of the small (ribosomal) subunit (SSU) processosomerequired for pre-18S rRNa processing; essentialnucleolar protein that, when overproduced,disrupts silencing 0.00580.15567&radic&radic S000004734SAS2YMR127CverifiedHistone acetyltransferase (HAT) catalytic subunit of the SAScomplex (Sas2p-Sas4p-Sas5p), which acetylatesfree histones and nucleosomes and regulatestranscriptional silencing; member of theMYSTacetyltransferase family 0.005790.15567&radic&radic&radic S000003509YGR277CUncharacterizedPutative protein of unknown function; sequence similarity to Pantetheine-phosphate adenylyltransferase (PPAT); YGR277C is an essential gene 0.005770.15445&radic&radic&radic&radic&radic S000002830SIP1YDR422CverifiedAlternate beta-subunit of the Snf1p kinase complex, may confersubstrate specificity; vacuolar proteincontaining KIS (Kinase-Interacting Sequence)and ASC (Association with Snf1 kinase Complex)domains involved in protein interactions 0.005740.15445&radic&radic&radic S000001314RPL34BYIL052CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl34Ap and has similarity to ratL34 ribosomal protein 0.005740.15445&radic&radic&radic S000000999STE20YHL007CverifiedSignal transducing kinase of the PAK (p21-activated kinase)family, involved in pheromone response andpseudohyphal/invasive growth pathways,activated by Cdc42p; binds Ste4p at a GBB motifpresent in noncatalytic domains of PAK kinases 0.005780.15445&radic&radic&radic S000006402SGE1YPR198WverifiedMembrane-associated multidrug transporter, acts as an extrusionpermease, member of the drug-resistance proteinfamily within the major facilitator superfamily(MFS), partial multicopy suppressor of gal11mutations 0.005770.15445&radic&radic&radic&radic&radic S000002847LRS4YDR439WverifiedProtein involved in rDNA silencing; positively chargedcoiled-coil protein with limited similarity tomyosin 0.005750.15445&radic S000002367NHP2YDL208WverifiedNuclear protein related to mammalian high mobility group (HMG)proteins, essential for function of H/ACA-typesnoRNPs, which are involved in 18S rRNAprocessing 0.005770.15445&radic S000000303YBR099CDubiousHypothetical protein 0.005740.15445&radic&radic S000003143SAE2YGL175CverifiedProtein with a role in accurate meiotic and mitoticdouble-strand break repair; phosphorylated inresponse to DNA damage and required for normalresistance to DNA-damaging agents 0.005760.15445&radic&radic&radic&radic S000003325YGR093WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus 0.005730.15435&radic&radic&radic S000003109HUL5YGL141WverifiedProtein with similarity to hect domain E3 ubiquitin-proteinligases, not essential for viability 0.005720.15383&radic&radic&radic&radic S000000829GAL83YER027CverifiedOne of three possible beta-subunits of the Snf1 kinase complex,allows nuclear localization of the Snf1 kinasecomplex in the presence of a nonfermentablecarbon source; contains glycogen-binding domain 0.005710.15364&radic&radic&radic S000002200SIR2YDL042CverifiedConserved NAD+ dependent histone deacetylase of the Sirtuinfamily involved in regulation of lifespan;plays roles in silencing at HML, HMR,telomeres, and the rDNA locus; negativelyregulates initiation of DNA replication 0.005710.15364 S000001518UGP1YKL035WverifiedUDP-glucose pyrophosphorylase (UGPase), catalyses thereversible formation of UDP-Glc from glucose1-phosphate and UTP, involved in a wide varietyof metabolic pathways, expression modulated byPho85p through Pho4p 0.00570.15334&radic&radic&radic S000001537DEF1YKL054CverifiedRNAPII degradation factor, forms a complex with Rad26p inchromatin, enables ubiquitination andproteolysis of RNAPII present in an elongationcomplex 0.00570.15334&radic&radic&radic S000000158YBL062WDubiousHypothetical protein 0.005690.15334&radic&radic&radic&radic S000003209DOC1YGL240WverifiedProcessivity factor required for the ubiquitination activity ofthe anaphase promoting complex (APC), mediatesthe activity of the APC by contributing tosubstrate recognition; involved in cyclinproteolysis 0.005670.1528&radic&radic&radic&radic&radic&radic&radic S000000868YER066WUncharacterizedHypothetical protein 0.005670.1528 S000002725HIM1YDR317WverifiedProtein of unknown function involved in DNA repair 0.005670.1528&radic&radic&radic&radic S000006257YPR053CDubiousHypothetical protein 0.005670.1528&radic&radic S000002461CDC34YDR054CverifiedUbiquitin-conjugating enzyme or E2; together with Skp1p, Rbx1p,Cdc53p, and an F-box protein, forms aubiquitin-protein ligase called the SCF complexwhich regulates cell cycle progression bytargeting key substrates for degradation 0.005610.15084&radic&radic&radic&radic S000002161MCD1YDL003WverifiedEssential protein required for sister chromatid cohesion inmitosis and meiosis; subunit of the cohesincomplex; expression is cell cycle regulated andpeaks in S phase 0.005660.15084&radic&radic&radic S000002194PUS9YDL036CverifiedMitochondrial tRNA pseudouridine synthase involved inpseudouridylation of mitochondrial tRNAs atposition 32 0.005640.15084&radic&radic&radic&radic&radic S000003487COQ6YGR255CverifiedPutative flavin-dependent monooxygenase, involved in ubiquinone(Coenzyme Q) biosynthesis; located on thematrix side of the mitochondrial inner membrane 0.005630.15084&radic&radic S000001859MOB2YFL034C-BverifiedComponent of the RAM signaling network, localizes and activatesthe Ace2p in the daughter cell nucleus todirect daughter cell-specific transcription ofseveral genes involved in cell separation;Mob1p-like protein 0.005640.15084&radic&radic&radic&radic S000005679PDR5YOR153WverifiedShort-lived membrane ABC (ATP-binding cassette) transporter,actively exports various drugs, expressionregulated by Pdr1p; also involved in steroidtransport, cation resistance, and cellulardetoxification during exponential growth 0.005620.15084&radic S000000364CDC28YBR160WverifiedCatalytic subunit of the main cell cycle cyclin-dependentkinase (CDK); alternately associates with G1cyclins (CLNs) and G2/M cyclins (CLBs) whichdirect the CDK to specific substrates 0.005610.15084&radic&radic&radic&radic S000005868RPA190YOR341WverifiedRNA polymerase I subunit; largest subunit of RNA polymerase I 0.005650.15084&radic S000003149GTS1YGL181WverifiedProtein containing a zinc-finger in the N-terminus and a longGln-rich region in the C-terminus; regulatesultradian rhythm, cell size, cell cycle,lifespan, sporulation, heat tolerance, andmultidrug transport 0.005660.15084&radic&radic S000003796RAD26YJR035WverifiedProtein involved in transcription-coupled repair nucleotideexcision repair of UV-induced DNA lesions;homolog of human CSB protein 0.005660.15084&radic&radic&radic S000006322YPR118WVerifiedMethylthioribose-1-phosphate isomerase, catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway 0.005640.15084&radic&radic&radic&radic S000004234MAP1YLR244CverifiedMethionine aminopeptidase, catalyzes the cotranslationalremoval of N-terminal methionine from nascentpolypeptides; function is partially redundantwith that of Map2p 0.00560.15084&radic&radic&radic&radic S000005708RPS30BYOR182CverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps30Ap and has similarity to ratS30 ribosomal protein 0.005640.15084&radic&radic&radic&radic&radic S000002458YDR051CUncharacterizedHypothetical protein 0.005630.15084&radic&radic&radic&radic&radic&radic S000005204YNL260CUncharacterizedPutative protein of unknown function with similarity to a human protein overexpressed in oral cancers; localizes to the nucleus and cytoplasm; YNL260C is an essential gene 0.005650.15084&radic&radic&radic S000005051YAF9YNL107WverifiedSubunit of both the NuA4 histone H4 acetyltransferase complexand the SWR1 complex, may function toantagonize silencing near telomeres; interactsdirectly with Swc4p, has homology to humanleukemogenic protein AF9, contains a YEATSdomain 0.005640.15084&radic&radic S000000124YBL028CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis 0.005620.15084&radic&radic&radic S000003920SOR1YJR159WverifiedSorbitol dehydrogenase; expression is induced in the presenceof sorbitol 0.005630.15084 S000004631FAR8YMR029CverifiedProtein involved in G1 cell cycle arrest in response topheromone, in a pathway different from theFar1p-dependent pathway; interacts with Far3p,Far7p, Far9p, Far10p, and Far11p 0.005610.15084&radic&radic&radic&radic S000002741YDR333CUncharacterizedHypothetical protein 0.005580.15009&radic&radic&radic&radic&radic S000006007ELP3YPL086CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;exhibits histone acetyltransferase activitythat is directed to histones H3 and H4;disruption confers resistance to K. lactiszymotoxin 0.005590.15009&radic&radic&radic&radic&radic S000003897YJR136CUncharacterizedPutative protein of unknown function; may interact with mitochondrial ribosomal protein Rsm23p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.005590.15009&radic&radic&radic S000002178RPN4YDL020CverifiedTranscription factor that stimulates expression of proteasomegenes; Rpn4p levels are in turn regulated bythe 26S proteasome in a negative feedbackcontrol mechanism; RPN4 is transcriptionallyregulated by various stress responses 0.005580.15009&radic&radic S000001492MRT4YKL009WverifiedProtein involved in mRNA turnover and ribosome assembly,localizes to the nucleolus 0.005590.15009&radic&radic&radic S000003256THG1YGR024CverifiedtRNAHis guanylyltransferase, adds a guanosine residue to the 5'end of tRNAHis after transcription and RNase Pcleavage; couples nuclear division andmigration to cell budding and cytokinesis;essential enzyme conserved among eukaryotes 0.005580.15009&radic&radic&radic&radic S000006400YPR196WUncharacterizednuclear protein (putative) 0.005590.15009&radic&radic&radic&radic&radic S000003274YGR042WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 0.005570.14999&radic&radic&radic&radic&radic&radic&radic&radic S000005996GCR1YPL075WverifiedTranscriptional activator of genes involved in glycolysis;DNA-binding protein that interacts andfunctions with the transcriptional activatorGcr2p 0.005570.14999&radic&radic&radic&radic&radic S000002351ARF1YDL192WverifiedADP-ribosylation factor, GTPase of the Ras superfamily involvedin regulation of coated formation vesicles inintracellular trafficking within the Golgi;functionally interchangeable with Arf2p 0.005560.1499&radic&radic&radic&radic&radic S000001858RPO41YFL036WverifiedMitochondrial RNA polymerase; single subunit enzyme similar tothose of T3 and T7 bacteriophages; requires aspecificity subunit encoded by MTF1 forpromoter recognition 0.005530.14922 S000000070ADE1YAR015WverifiedN-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR)synthetase, required for 'de novo' purinenucleotide biosynthesis; red pigmentaccumulates in mutant cells deprived of adenine 0.005530.14922&radic&radic&radic&radic&radic&radic&radic&radic S000005562PEP12YOR036WverifiedTarget membrane receptor (t-SNARE) for vesicular intermediatestraveling between the Golgi apparatus and thevacuole; controls entry of biosynthetic,endocytic, and retrograde traffic into theprevacuolar compartment; syntaxin 0.005530.14922&radic&radic&radic&radic S000000730YEA4YEL004WverifiedUridine diphosphate-N-acetylglucosamine (UDP-GlcNAc)transporter required for cell wall chitinsynthesis; localized to the ER 0.005530.14922&radic&radic&radic&radic&radic S000001673CNB1YKL190WverifiedCalcineurin B; the regulatory subunit of calcineurin, aCa++/calmodulin-regulated protein phosphatasewhich regulates Crz1p (a stress-responsetranscription factor), the other calcineurinsubunit is encoded by CNA1 and/or CMP1 0.005540.14922&radic&radic&radic&radic&radic S000005767MET7YOR241WverifiedFolylpolyglutamate synthetase, catalyzes extension of theglutamate chains of the folate coenzymes,required for methionine synthesis and formaintenance of mitochondrial DNA 0.005540.14922&radic&radic&radic S000003737ECM25YJL201WverifiedNon-essential protein of unknown function; promoter contains aconsensus binding sequence for factor Abf1p 0.005490.1479&radic&radic&radic S000002562CPR1YDR155CverifiedCytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin),catalyzes the cis-trans isomerization ofpeptide bonds N-terminal to proline residues;binds the drug cyclosporin A 0.005510.1479&radic&radic&radic S000000374NPL4YBR170CverifiedEndoplasmic reticulum and nuclear membrane protein, forms acomplex with Cdc48p and Ufd1p that recognizesubiquitinated proteins in the endoplasmicreticulum and delivers them to the proteasomefor degradation 0.005510.1479&radic&radic&radic S000002722RAD34YDR314CverifiedProtein involved in nucleotide excision repair (NER);homologous to RAD4 0.005510.1479&radic&radic&radic&radic&radic&radic&radic S000001458MUC1YIR019CverifiedGPI-anchored cell surface glycoprotein required for diploidpseudohyphal formation and haploid invasivegrowth, transcriptionally regulated by the MAPKpathway (via Ste12p and Tec1p) and the cAMPpathway (via Flo8p) 0.005490.1479&radic&radic&radic S000001894SPB4YFL002CverifiedPutative ATP-dependent RNA helicase, nucleolar protein requiredfor synthesis of 60S ribosomal subunits at alate step in the pathway; sediments with 66Spre-ribosomes in sucrose gradients 0.005470.14757&radic&radic S000003098CEG1YGL130WverifiedAlpha (guanylyltransferase) subunit of the mRNA capping enzyme,a heterodimer (the other subunit is CET1, anRNA 5'-triphophatase) involved in adding the 5'cap to mRNA; the mammalian enzyme is a singlebifunctional polypeptide 0.005470.14757&radic&radic S000002327SFA1YDL168WverifiedBifunctional enzyme containing both alcohol dehydrogenase andglutathione-dependent formaldehydedehydrogenase activities, functions informaldehyde detoxification and formation oflong chain and complex alcohols, regulated byHog1p-Sko1p 0.005460.14592&radic S000001185RPC10YHR143W-AverifiedRNA polymerase subunit, found in RNA polymerase complexes I,II, and III 0.005430.14592&radic&radic&radic&radic&radic&radic S000004683CTF18YMR078CverifiedSubunit of a complex with Ctf8p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion; may have overlappingfunctions with Rad24p in the DNA damagereplication checkpoint 0.005430.14592&radic&radic&radic S000004980YNL035CUncharacterizedPutative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene 0.00540.14592&radic S000002773ESF1YDR365CverifiedNucleolar protein involved in pre-rRNA processing; depletioncauses severely decreased 18S rRNA levels 0.00540.14592&radic&radic&radic&radic&radic&radic S000005506PSF3YOL146WverifiedSubunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), whichis localized to DNA replication origins andimplicated in assembly of the DNA replicationmachinery 0.005410.14592&radic&radic S000003093MET13YGL125WverifiedIsozyme of methylenetetrahydrofolate reductase, catalyzes thereduction of 5,10-methylenetetrahydrofolate to5-methyltetrahydrofolate in the methioninebiosynthesis pathway 0.005450.14592&radic&radic&radic&radic S000001608RRN3YKL125WverifiedProtein required for transcription of rDNA by RNA polymerase I;transcription factor independent of DNAtemplate; involved in recruitment of RNApolymerase I to rDNA 0.005450.14592&radic&radic&radic&radic S000002869MFA1YDR461WverifiedMating pheromone a-factor, made by a cells; interacts withalpha cells to induce cell cycle arrest andother responses leading to mating; biogenesisinvolves C-terminal modification, N-terminalproteolysis, and export; also encoded by MFA2 0.00540.14568&radic&radic&radic&radic S000000259PRP6YBR055CverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.005370.14519&radic&radic S000005200FOL1YNL256WverifiedMultifunctional enzyme of the folic acid biosynthesis pathway,has dihydropteroate synthetase,dihydro-6-hydroxymethylpterinpyrophosphokinase, and dihydroneopterinaldolase activities 0.005380.14519&radic&radic&radic S000004211RSA3YLR221CverifiedProtein with a likely role in ribosomal maturation, requiredfor accumulation of wild-type levels of large(60S) ribosomal subunits; binds to the helicaseDbp6p in pre-60S ribosomal particles in thenucleolus 0.005380.14519&radic&radic S000002918SMT3YDR510WverifiedUbiquitin-like protein of the SUMO family, conjugated to lysineresidues of target proteins; regulateschromatid cohesion, chromosome segregation,APC-mediated proteolysis, DNA replication andseptin ring dynamics 0.005370.14468&radic&radic S000003336SRB5YGR104CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation; involved intelomere maintenance 0.005370.14468&radic&radic&radic&radic&radic S000004427TSR2YLR435WverifiedProtein with a potential role in pre-rRNA processing 0.005360.14468&radic&radic&radic S000003422YGR190CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W 0.005350.14468&radic S000002909PLM2YDR501WverifiedProtein required for partitioning of the 2-micron plasmid 0.005350.14409&radic S000001794PRP16YKR086WverifiedRNA helicase in the DEAH-box family involved in the secondcatalytic step of splicing, exhibitsATP-dependent RNA unwinding activity 0.005340.14409&radic&radic S000003271YGR039WDubiousHypothetical protein 0.005340.14409&radic&radic&radic&radic&radic S000003317RPL11BYGR085CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl11Ap; involved in ribosomalassembly; depletion causes degradation ofproteins and RNA of the 60S subunit; hassimilarity to E. coli L5 and rat L11 0.005350.14409&radic S000001557MUD2YKL074CverifiedProtein involved in early pre-mRNA splicing; component of thepre-mRNA-U1 snRNP complex, the commitmentcomplex; interacts with Msl5p/BBP splicingfactor and Sub2p; similar to metazoan splicingfactor U2AF65 0.005340.14409&radic&radic&radic&radic&radic&radic S000000002VPS8YAL002WverifiedMembrane-associated hydrophilic protein that interacts with thesmall GTPase, Vps21p, to facilitate solublevacuolar protein localization; required forlocalization and trafficking of the CPY sortingreceptor; contains a RING finger motif 0.005330.14409&radic&radic&radic&radic&radic&radic S000005267LEM3YNL323WverifiedMembrane protein of the plasma membrane and ER, involved intranslocation of phospholipids andalkylphosphocholine drugs across the plasmamembrane 0.005340.14409&radic&radic&radic S000004390SKI2YLR398CverifiedPutative RNA helicase, involved in exosome mediated 3' to 5'mRNA degradation and translation inhibition ofnon-poly(A) mRNAs; forms complex with Ski3p andSki8p; required for repressing propagation ofdsRNA viruses 0.005320.14322&radic&radic&radic S000004951LST8YNL006WverifiedProtein required for the transport of amino acid permease Gap1pfrom the Golgi to the cell surface; componentof the TOR signaling pathway; associates withboth Tor1p and Tor2p; contains a WD-repeat 0.005320.14322 S000000101PDR3YBL005WverifiedTranscriptional activator of the pleiotropic drug resistancenetwork, regulates expression of ATP-bindingcassette (ABC) transporters through binding tocis-acting sites known as PDREs (PDR responsiveelements) 0.00530.14322&radic&radic&radic&radic S000000636MATALPHA1YCR040WverifiedTranscriptional co-activator involved in regulation ofmating-type-specific gene expression; targetsthe transcription factor Mcm1p to the promotersof alpha-specific genes; one of two genesencoded by the MATalpha mating type cassette 0.00530.14322&radic S000002573SEC5YDR166CverifiedEssential 107kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which has the essential function ofmediating polarized targeting of secretoryvesicles to active sites of exocytosis 0.005310.14322&radic&radic&radic S000005933RRP12YPL012WverifiedProtein required for export of the ribosomal subunits;associates with the RNA components of thepre-ribosomes; contains HEAT-repeats 0.00530.14305&radic&radic&radic&radic S000001049ERG11YHR007CverifiedLanosterol 14-alpha-demethylase, catalyzes the C-14demethylation of lanosterol to form4,4''-dimethylcholesta-8,14,24-triene-3-beta-ol in theergosterol biosynthesis pathway; member of thecytochrome P450 family 0.00530.14305&radic&radic&radic&radic S000006391RPO26YPR187WverifiedRNA polymerase subunit ABC23, common to RNA polymerases I, II,and III; part of central core; similar tobacterial omega subunit 0.005290.14244&radic&radic&radic&radic&radic&radic&radic&radic&radic S000004738RRB1YMR131CverifiedEssential nuclear protein involved in early steps of ribosomebiogenesis; physically interacts with theribosomal protein Rpl3p 0.005280.14244&radic&radic S000003648MDV1YJL112WverifiedPeripheral protein of the cytosolic face of the mitochondrialouter membrane, required for mitochondrialfission; interacts with Fis1p and with thedynamin-related GTPase Dnm1p; contains WDrepeats 0.005280.14244 S000002311YDL152WDubiousHypothetical protein; open reading frame overlaps 5' end of essential SAS10 gene encoding a component of the small ribosomal subunit processosome 0.005290.14244&radic&radic&radic&radic S000000485DUG2YBR281CuncharacterizedProtein involved in alternative pathway of glutathionedegradation; green fluorescent protein(GFP)-fusion protein localizes to the cytoplasmand nucleus; YBR281C is not an essential gene 0.005280.14244&radic&radic&radic S000006324CLB5YPR120CverifiedB-type cyclin involved in DNA replication during S phase;activates Cdc28p to promote initiation of DNAsynthesis; functions in formation of mitoticspindles along with Clb3p and Clb4p; mostabundant during late G1 phase 0.005290.14244&radic&radic S000000016YAL018CUncharacterizedHypothetical protein 0.005260.14218&radic&radic&radic&radic&radic S000003081SLD3YGL113WverifiedProtein involved in the initiation of DNA replication, requiredfor proper assembly of replication proteins atthe origins of replication; interacts withCdc45p 0.005270.14218&radic&radic&radic&radic S000003210KAP114YGL241WverifiedKaryopherin, responsible for nuclear import of Spt15p, histonesH2A and H2B, and Nap1p; amino terminus showssimilarity to those of other importins,particularly Cse1p; localization is primarilynuclear 0.005270.14218&radic&radic&radic&radic&radic&radic&radic S000003310PAC10YGR078CverifiedPart of the heteromeric co-chaperone GimC/prefoldin complex,which promotes efficient protein folding 0.005260.14218&radic&radic&radic&radic S000001243RPN10YHR200WverifiedNon-ATPase base subunit of the 19S regulatory particle (RP) ofthe 26S proteasome; N-terminus plays a role inmaintaining the structural integrity of the RP;binds selectively to polyubiquitin chains;homolog of the mammalian S5a protein 0.005260.14218&radic&radic&radic&radic&radic S000003416UBR1YGR184CverifiedUbiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2pto ubiquitinate substrates of the N-end rulepathway; binds to the Rpn2p, Rpt1p, and Rpt6pproteins of the 19S particle of the 26Sproteasome 0.005260.14178&radic S000003645UTP10YJL109CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.005240.14162&radic&radic S000003563RNR2YJL026WverifiedRibonucleotide-diphosphate reductase (RNR), small subunit; theRNR complex catalyzes the rate-limiting step indNTP synthesis and is regulated by DNAreplication and DNA damage checkpoint pathwaysvia localization of the small subunits 0.005240.14162&radic&radic&radic&radic&radic S000004907YMR293CUncharacterizedPutative protein similar to bacterial glutamyl-tRNA amidotransferases; may be involved in aerobic respiration; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR293C is not an essential gene 0.005240.14162&radic&radic S000000928NSA2YER126CverifiedConstituent of 66S pre-ribosomal particles, involved in 60Sribosomal subunit biogenesis 0.005240.14162&radic S000006380BET2YPR176CverifiedBeta subunit of Type II geranylgeranyltransferase required forvesicular transport between the endoplasmicreticulum and the Golgi; provides a membraneattachment moiety to Rab-like proteins Ypt1pand Sec4p 0.005240.14162&radic S000002794MUS81YDR386WverifiedHelix-hairpin-helix protein, involved in DNA repair andreplication fork stability; functions as anendonuclease in complex with Mms4p; interactswith Rad54p 0.005210.14111&radic&radic&radic S000004141PCD1YLR151CverifiedPeroxisomal nudix pyrophosphatase with specificity for coenzymeA and CoA derivatives, may function to removepotentially toxic oxidized CoA disulfide fromperoxisomes to maintain the capacity forbeta-oxidation of fatty acids 0.005220.14111&radic&radic&radic&radic&radic&radic S000000293YBR089WDubiousHypothetical protein 0.005210.14086&radic S000000214HHT1YBR010WverifiedOne of two identical histone H3 proteins (see also HHT2); corehistone required for chromatin assembly,involved in heterochromatin-mediated telomericand HM silencing; regulated by acetylation,methylation, and mitotic phosphorylation 0.005210.14086&radic S000005409GSH2YOL049WverifiedGlutathione synthetase, catalyzes the ATP-dependent synthesisof glutathione (GSH) fromgamma-glutamylcysteine and glycine; induced byoxidative stress and heat shock 0.005190.14033&radic&radic&radic S000002172NOP1YDL014WverifiedNucleolar protein, component of the small subunit processomecomplex, which is required for processing ofpre-18S rRNA; has similarity to mammalianfibrillarin &radic0.005190.14033 S000003506TAF1YGR274CverifiedTFIID subunit (145 kDa), involved in RNA polymerase IItranscription initiation, has histoneacetyltransferase activity, involved inpromoter binding and G1/S progression 0.00520.14033&radic&radic&radic&radic&radic&radic S000004170SAM1YLR180WverifiedS-adenosylmethionine synthetase, catalyzes transfer of theadenosyl group of ATP to the sulfur atom ofmethionine; one of two differentially regulatedisozymes (Sam1p and Sam2p) 0.005190.14033&radic&radic&radic&radic S000002211PBP4YDL053CverifiedPbp1p binding protein, interacts strongly with Pab1p-bindingprotein 1 (Pbp1p) in the yeast two-hybridsystem; also interacts with Lsm12p in acopurification assay 0.005190.14033&radic&radic&radic&radic S000005337ESF2YNR054CverifiedEssential nucleolar protein involved in pre-18S rRNAprocessing; component of the small subunit(SSU) processome; has sequence similarity tomABT1, a mouse transcription activator 0.00520.14033&radic S000003594BIT61YJL058CverifiedSubunit of TORC2(Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p-Slm1p-Slm2p), a membrane-associated complex thatregulates cell cycle-dependent actincytoskeletal dynamics during polarized growthand cell wall integrity 0.00520.14033&radic&radic S000003693FAR1YJL157CverifiedCyclin-dependent kinase inhibitor that mediates cell cyclearrest in response to pheromone; also forms acomplex with Cdc24p, Ste4p, and Ste18p that mayspecify the direction of polarized growthduring mating; potential Cdc28p substrate 0.00520.14033&radic&radic&radic&radic&radic&radic S000005201SIP3YNL257CverifiedProtein that activates transcription through interaction withDNA-bound Snf1p, C-terminal region has aputative leucine zipper motif; potential Cdc28psubstrate 0.005180.13984&radic&radic&radic&radic&radic S000003436ADE3YGR204WverifiedCytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase,involved in single carbon metabolism andrequired for biosynthesis of purines,thymidylate, methionine, and histidine