Yfunc lets you browse current and predicted gene functions in yeast

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Prediction of GO:0008380 "RNA splicing"

GO branch: BP
Number of currently annotated genes: 125

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest Huh:nucleusHarbison:SFL1_YPDTAP:158TAP:161Harbison:IME1_YPDHarbison:IME1_H2O2HiTAP:160Harbison:UGA3_YPDLum:WarfarinLum:AZT S000004107CLF1YLR117CverifiedEssential splicesome assembly factor; contains multipletetratricopeptide repeat (TPR) protein-bindingmotifs and interacts specifically with manyspliceosome components, may serve as a scaffoldduring splicesome assembly &radic0.893741&radic&radic&radic&radic&radic&radic S000001656SNU114YKL173WverifiedGTPase component of U5 snRNP involved in mRNA splicing viaspliceosome; binds directly to U5 snRNA;proposed to be involved in conformationalchanges of the spliceosome; similarity toribosomal translocation factor EF-2 &radic0.919461&radic&radic&radic&radic&radic&radic&radic&radic S000003959PRP19YLL036CverifiedSplicing factor associated with the spliceosome; contains aU-box, a motif found in a class of ubiquitinligases &radic0.948741&radic&radic&radic&radic&radic&radic&radic&radic S000006305SNT309YPR101WverifiedComponent of NineTeen complex (NTC) containing Prp19p involvedin mRNA splicing, interacts physically andgenetically with Prp19p &radic0.878860.97695&radic&radic&radic&radic&radic&radic S000004853CUS1YMR240CverifiedProtein required for assembly of U2 snRNP into the spliceosome,forms a complex with Hsh49p and Hsh155p &radic0.87030.97695&radic&radic&radic&radic&radic S000000914LSM4YER112WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA &radic0.87070.97695&radic&radic&radic&radic S000006386SMX3YPR182WverifiedCore Sm protein Sm F; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm F &radic0.863390.97154&radic&radic&radic&radic&radic&radic S000004265SMD2YLR275WverifiedCore Sm protein Sm D2; part of heteroheptameric complex (withSmb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D2 &radic0.865130.97154&radic&radic&radic&radic&radic&radic&radic S000003660LSM1YJL124CverifiedLsm (Like Sm) protein; forms heteroheptameric complex (withLsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p)involved in degradation of cytoplasmic mRNAs 0.861640.97058&radic S000000831SMB1YER029CverifiedCore Sm protein Sm B; part of heteroheptameric complex (withSmd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm B and Sm B' &radic0.860750.97058&radic&radic&radic&radic&radic&radic S000006072PRP46YPL151CverifiedSplicing factor that is found in the Cef1p subcomplex of thespliceosome &radic0.859340.9661&radic&radic&radic&radic&radic S000001323SNP1YIL061CverifiedComponent of U1 snRNP required for mRNA splicing viaspliceosome; may interact with poly(A)polymerase to regulate polyadenylation; homologof human U1 70K protein &radic0.856770.96242&radic&radic&radic&radic&radic S000004137SMD3YLR147CverifiedCore Sm protein Sm D3; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D3 &radic0.855260.96242&radic&radic&radic&radic&radic&radic&radic&radic S000002965SMX2YFL017W-AverifiedCore Sm protein Sm G; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm G &radic0.853640.96242&radic&radic&radic&radic S000003739PRP21YJL203WverifiedSubunit of the SF3a splicing factor complex, required forspliceosome assembly &radic0.844760.9589&radic&radic&radic&radic&radic&radic&radic&radic&radic S000001495PRP40YKL012WverifiedU1 snRNP protein involved in splicing, interacts with thebranchpoint-binding protein during theformation of the second commitment complex &radic0.810890.95833&radic&radic&radic&radic&radic S000002188PRP9YDL030WverifiedSubunit of the SF3a splicing factor complex, required forspliceosome assembly; acts after the formationof the U1 snRNP-pre-mRNA complex &radic0.816820.95833&radic&radic&radic&radic&radic&radic S000003811ISY1YJR050WverifiedComponent of the spliceosome complex involved in pre-mRNAsplicing, auxiliary splicing factor that maymodulate Syf1p activity and help optimizesplicing; isy1 syf2 double mutation activatesthe spindle checkpoint, causing cell cyclearrest &radic0.819740.95833&radic&radic S000002824SYF1YDR416WverifiedComponent of the spliceosome complex involved in pre-mRNAsplicing; involved in regulation of cell cycleprogression; similar to Drosophila crooked neckprotein &radic0.835660.95833&radic&radic&radic&radic&radic&radic S000001208PRP8YHR165CverifiedComponent of the U4/U6-U5 snRNP complex, involved in the secondcatalytic step of splicing &radic0.796780.95833&radic&radic S000006382PRP4YPR178WverifiedSplicing factor, component of the U4/U6-U5 snRNP complex &radic0.803790.95833&radic&radic&radic&radic&radic&radic&radic S000000122LSM2YBL026WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA &radic0.79650.95833&radic&radic&radic&radic&radic&radic&radic&radic S000002201PRP11YDL043CverifiedSubunit of the SF3a splicing factor complex, required forspliceosome assembly &radic0.840810.95833&radic&radic&radic&radic&radic&radic&radic&radic S000002648SNU56YDR240CverifiedComponent of U1 snRNP required for mRNA splicing viaspliceosome; yeast specific, no metazoancounterpart; interacts with mRNA in commitmentcomplex &radic0.829660.95833&radic&radic&radic&radic&radic&radic S000003245SNU71YGR013WverifiedComponent of U1 snRNP required for mRNA splicing viaspliceosome; yeast specific, no metazoancounterpart &radic0.824840.95833&radic&radic&radic&radic&radic&radic&radic&radic S000006134LEA1YPL213WverifiedComponent of U2 snRNP; disruption causes reduced U2 snRNPlevels; physically interacts with Msl1p;invovled in telomere maintenance; putativehomolog of human U2A' snRNP protein &radic0.794030.95833&radic&radic&radic&radic&radic S000000269ECM2YBR065CverifiedPre-mRNA splicing factor, facilitates the cooperative formationof U2/U6 helix II in association with stem IIin the spliceosome, function may be regulatedby Slu7p &radic0.801190.95833&radic&radic&radic&radic&radic&radic S000005835SNU66YOR308CverifiedComponent of the U4/U6.U5 snRNP complex involved in pre-mRNAsplicing via spliceosome; has homology to humanSART-1 and to an S. pombe protein; snu66 nullmutation confers cold-sensitivity but is notlethal at normal growth temperatures &radic0.788220.95833&radic&radic&radic&radic&radic&radic&radic&radic&radic S000004901HSH155YMR288WverifiedU2-snRNP associated splicing factor that forms extensiveassociations with the branch site-3' splicesite-3' exon region upon prespliceosomeformation; similarity to the mammalian U2snRNP-associated splicing factor SAP155 &radic0.803310.95833&radic&radic&radic&radic&radic&radic&radic&radic S000004732STO1YMR125WverifiedLarge subunit of the nuclear mRNA cap-binding protein complex,interacts with Npl3p to carry nuclear poly(A)+mRNA to cytoplasm; also involved in nuclearmRNA degradation and telomere maintenance;orthologous to mammalian CBP80 &radic0.814890.95833&radic&radic&radic&radic&radic&radic&radic S000002881PRP3YDR473CverifiedSplicing factor, component of the U4/U6-U5 snRNP complex &radic0.787590.95755&radic&radic&radic&radic&radic&radic&radic S000005685SME1YOR159CverifiedCore Sm protein Sm E; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm E &radic0.780430.95652&radic&radic&radic&radic&radic&radic&radic S000002368CWC2YDL209CverifiedProtein involved in pre-mRNA splicing, component of a complexcontaining Cef1p; interacts with Prp19p;contains an RNA recognition motif; hassimilarity to S. pombe Cwf2p &radic0.782880.95652&radic&radic&radic&radic&radic S000000323MUD1YBR119WverifiedU1 snRNP A protein, homolog of human U1-A; involved in nuclearmRNA splicing &radic0.774610.95638&radic&radic&radic&radic&radic&radic&radic S000001448MSL1YIR009WverifiedU2B component of U2 snRNP, involved in splicing, binds the U2snRNA stem-loop IV in vitro; does not containthe conserved C-terminal RNA binding domainfound in other family members &radic0.771630.95365&radic&radic&radic&radic S000004826CEF1YMR213WverifiedEssential splicing factor; associated with Prp19p and thespliceosome, contains an N-terminal c-Myb DNAbinding motif necessary for cell viability butnot for Prp19p association, evolutionarilyconserved and homologous to S. pombe Cdc5p &radic0.768590.95069&radic&radic&radic S000005091LSM7YNL147WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA &radic0.763710.94727&radic&radic S000004416SPP382YLR424WverifiedEssential protein that forms a dimer with Ntr2p; also forms atrimer, with Ntr2p and Prp43p, that is involvedin spliceosome disassembly; found also in amultisubunit complex with the splicing factorClf1p; suppressor of prp38-1 mutation &radic0.761770.94494&radic&radic&radic&radic&radic&radic&radic S000000948LSM5YER146WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA &radic0.757620.94199&radic S000003306SMD1YGR074WverifiedCore Sm protein Sm D1; part of heteroheptameric complex (withSmb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D1 &radic0.758150.94199&radic&radic&radic&radic&radic&radic&radic&radic S000003783LSM8YJR022WverifiedLsm (Like Sm) protein; forms heteroheptameric complex (withLsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p)that is part of spliceosomal U6 snRNP and isalso implicated in processing of pre-tRNA,pre-snoRNA, and pre-rRNA &radic0.741770.93983&radic&radic&radic&radic&radic S000002786LSM6YDR378CverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA &radic0.739140.93736&radic&radic&radic S000003323PRP31YGR091WverifiedSplicing factor, component of the U4/U6-U5 snRNP complex &radic0.739710.93736&radic&radic&radic&radic&radic&radic&radic&radic S000002245LUC7YDL087CverifiedEssential protein associated with the U1 snRNP complex;splicing factor involved in recognition of 5'splice site &radic0.739020.93601&radic&radic&radic&radic S000000030PRP45YAL032CverifiedProtein required for pre-mRNA splicing; associates with thespliceosome and interacts with splicing factorsPrp22p and Prp46p; orthologous to humantranscriptional coactivator SKIP and canactivate transcription of a reporter gene &radic0.730060.93455&radic S000006434LSM3YLR438C-AverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA &radic0.730920.93455&radic S000000259PRP6YBR055CverifiedSplicing factor, component of the U4/U6-U5 snRNP complex &radic0.720450.93415&radic&radic&radic&radic S000004509PRP39YML046WverifiedU1 snRNP protein involved in splicing, contains multipletetriatricopeptide repeats &radic0.709870.92758&radic&radic&radic&radic S000004513RSE1YML049CverifiedProtein involved in pre-mRNA splicing; component of thepre-spliceosome; associates with U2 snRNA;involved in ER to Golgi transport &radic0.701470.92325&radic&radic&radic S000006286DIB1YPR082Cverified17-kDa component of the U4/U6aU5 tri-snRNP, plays an essentialrole in pre-mRNA splicing, orthologue of hDIM1,the human U5-specific 15-kDa protein &radic0.671610.9116&radic&radic&radic&radic&radic S000002772CDC40YDR364CverifiedPre-mRNA splicing factor, important for catalytic step II ofpre-mRNA splicing and plays a role in cellcycle progression; required for DNA synthesisduring mitosis and meiosis; has WD repeats &radic0.670150.91119&radic&radic S000002643PRP42YDR235WverifiedU1 snRNP protein involved in splicing, required for U1 snRNPbiogenesis; contains multipletetriatricopeptide repeats &radic0.65260.90183&radic&radic&radic&radic&radic&radic&radic&radic&radic S000002495SLU7YDR088CverifiedRNA splicing factor, required for ATP-independent portion of2nd catalytic step of spliceosomal RNAsplicing; interacts with Prp18p; contains zincknuckle domain &radic0.637590.89416&radic&radic&radic S000002840NPL3YDR432WverifiedRNA-binding protein that carries poly(A)+ mRNA from the nucleusinto the cytoplasm; phosphorylation by Sky1p inthe cytoplasm may promote release of mRNAs 0.628370.8871&radic&radic&radic&radic&radic S000004289YHC1YLR298CverifiedComponent of the U1 snRNP complex required for pre-mRNAsplicing; putative ortholog of human U1Cprotein, which is involved in formation of acomplex between U1 snRNP and the pre-mRNA 5'splice site &radic0.625970.88549&radic&radic&radic&radic&radic&radic S000000815PRP22YER013WverifiedDEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase,associates with lariat intermediates before thesecond catalytic step of splicing; mediatesATP-dependent mRNA release from the spliceosomeand unwinds RNA duplexes &radic0.60390.87476&radic&radic&radic&radic&radic S000001128NAM8YHR086WverifiedRNA binding protein, component of the U1 snRNP protein; mutantsare defective in meiotic recombination and information of viable spores, involved in theformation of DSBs through meiosis-specificsplicing of MER2 pre-mRNA &radic0.581190.86106&radic&radic&radic&radic&radic&radic S000000659BUD31YCR063WverifiedProtein involved in bud-site selection; analysis of integratedhigh-throughput datasets predicts aninvolvement in RNA splicing; diploid mutantsdisplay a random budding pattern instead of thewild-type bipolar pattern &radic0.580810.86106&radic&radic S000003844CSN12YJR084WverifiedSubunit of the Cop9 signalosome, which is required fordeneddylation, or removal of the ubiquitin-likeprotein Rub1p from Cdc53p (cullin); involved inadaptation to pheromone signaling 0.565660.85018&radic&radic&radic&radic&radic S000003307PRP38YGR075CverifiedUnique component of the U4/U6.U5 tri-snRNP particle,dispensable for spliceosome assembly, butrequired for conformational changes which leadto catalytic activation of the spliceosome &radic0.563890.84902&radic&radic&radic&radic&radic&radic S000006261BRR1YPR057WverifiedsnRNP protein component of spliceosomal snRNPs, required forpre-mRNA splicing and snRNP biogenesis; in nullmutant newly-synthesized snRNAs aredestabilized and 3'-end processing is slowed &radic0.56380.84902&radic&radic&radic&radic S000003510CWC22YGR278WverifiedEssential protein, component of a complex containing Cef1p, hassimilarity to S. pombe Cwf22p; putativespliceosomal component, based on computationalanalysis of large-scale protein-proteininteraction data &radic0.556850.84443&radic&radic&radic&radic&radic&radic&radic S000002256SNU23YDL098CverifiedComponent of U4/U6.U5 snRNP involved in mRNA splicing viaspliceosome &radic0.555830.84361&radic&radic&radic&radic&radic S000001578YJU2YKL095WverifiedEssential nuclear protein; putative spliceosomal componentinvolved in mRNA splicing, based oncomputational analysis of large-scaleprotein-protein interaction data &radic0.552980.84075&radic&radic S000005294PRP2YNR011CverifiedRNA-dependent ATPase in the DEAH-box family, required foractivation of the spliceosome before the firsttransesterification step in RNA splicing &radic0.542580.83463&radic&radic&radic S000004881PRP24YMR268CverifiedSplicing factor that reanneals U4 and U6 snRNPs duringspliceosome recycling &radic0.536960.83347&radic&radic&radic&radic&radic S000000170AAR2YBL074CverifiedComponent of the U5 snRNP, required for splicing of U3precursors; originally described as a splicingfactor specifically required for splicingpre-mRNA of the MATa1 cistron &radic0.528010.82618&radic&radic&radic&radic&radic&radic&radic S000003096CWC23YGL128CverifiedComponent of a complex containing Cef1p, putatively involved inpre-mRNA splicing; has similarity to E. coliDnaJ and other DnaJ-like proteins and to S.pombe Cwf23p 0.525840.82496&radic&radic S000003088PRP43YGL120CverifiedRNA helicase in the DEAH-box family, functions in both RNApolymerase I and polymerase II transcriptmetabolism, involved in release of thelariat-intron from the spliceosome &radic0.517630.82137&radic&radic&radic S000004650NUP116YMR047CverifiedSubunit of the nuclear pore complex (NPC) that is localized toboth sides of the pore; contains a repetitiveGLFG motif that interacts with mRNA exportfactor Mex67p and with karyopherin Kap95p;homologous to Nup100p &radic0.517570.82137&radic S000006099CBC2YPL178WverifiedSmall subunit of the heterodimeric cap binding complex thatalso contains Sto1p, component of thespliceosomal commitment complex; interacts withNpl3p, possibly to package mRNA for export fromthe nucleus; contains an RNA-binding motif &radic0.517490.82116&radic&radic&radic&radic&radic&radic S000000974BRR2YER172CverifiedRNA-dependent ATPase RNA helicase involved in the facilitationand disruption of snRNA interactions, requiredfor disruption of U4/U6 base-pairing in nativesnRNPs to activate the spliceosome forcatalysis &radic0.481810.80242&radic&radic S000001083SRB2YHR041CverifiedGeneral transcription factor, subunit of the RNA polymerase IImediator complex; associates with corepolymerase subunits to form the RNA polymeraseII holoenzyme; involved in telomere maintenance 0.461790.79069&radic&radic&radic&radic S000001551NUP100YKL068WverifiedSubunit of the nuclear pore complex (NPC) that is localized toboth sides of the pore; contains a repetitiveGLFG motif that interacts with mRNA exportfactor Mex67p and with karyopherin Kap95p;homologous to Nup116p 0.460590.78994&radic&radic&radic&radic S000002319DHH1YDL160CverifiedCytoplasmic DExD/H-box helicase, stimulates mRNA decapping,coordinates distinct steps in mRNA function anddecay, interacts with both the decapping anddeadenylase complexes, may have a role in mRNAexport and translation 0.4540.78575&radic&radic&radic S000001794PRP16YKR086WverifiedRNA helicase in the DEAH-box family involved in the secondcatalytic step of splicing, exhibitsATP-dependent RNA unwinding activity &radic0.452350.78497&radic S000005499CDC33YOL139CverifiedCytoplasmic mRNA cap binding protein; the eIF4E-cap complex isresponsible for mediating cap-dependent mRNAtranslation via interactions with thetranslation initiation factor eIF4G (Tif4631por Tif4632p) 0.449980.78445&radic&radic S000000392NTC20YBR188CverifiedMember of a complex, including Prp19p, that binds to thespliceosome; required for pre-mRNA splicing &radic0.450120.78445&radic&radic&radic&radic&radic S000004095SEN2YLR105CverifiedSubunit of the tRNA splicing endonuclease, which is composed ofSen2p, Sen15p, Sen34p, and Sen54p; Sen2pcontains the active site for tRNA 5' splicesite cleavage and has similarity to Sen34p andto Archaeal tRNA splicing endonuclease &radic0.43880.77643&radic S000000356SPP381YBR152WverifiedmRNA splicing factor, component of U4/U6.U5 tri-snRNP;interacts genetically and physically withPrp38p &radic0.405940.75006&radic&radic&radic S000005846HSH49YOR319WverifiedU2-snRNP associated splicing factor with similarity to themammalian splicing factor SAP49; proposed tofunction as a U2-snRNP assembly factor alongwith Hsh155p and binding partner Cus1p;contains two RNA recognition motifs (RRM) &radic0.396620.74351&radic&radic&radic&radic S000007270COBQ0105verifiedCytochrome b, mitochondrially encoded subunit of theubiquinol-cytochrome c reductase complex whichincludes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p,Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p 0.376690.725 S000003394TIF4631YGR162WverifiedTranslation initiation factor eIF4G, subunit of the mRNAcap-binding protein complex (eIF4F) that alsocontains eIF4E (Cdc33p); associates with thepoly(A)-binding protein Pab1p, also interactswith eIF4A (Tif1p); homologous to Tif4632p 0.371310.7196&radic S000003060NUP145YGL092WverifiedEssential nucleoporin, catalyzes its own cleavage in vivo togenerate a C-terminal fragment that assemblesinto the Nup84p subcomplex of the nuclear porecomplex, and an N-terminal fragment of unknownfunction that is homologous to Nup100p &radic0.36370.71106 S000001199LIN1YHR156CverifiedNon-essential component of U5 snRNP; nuclear protein;physically interacts with Irr1p of cohesincomplex; may link together proteins involved inchromosome segregation, mRNA splicing and DNAreplication 0.347190.68902&radic&radic&radic S000002651PRP28YDR243CverifiedRNA helicase in the DEAD-box family, involved in RNAisomerization at the 5' splice site &radic0.341810.68342&radic&radic&radic&radic&radic S000000066SEN34YAR008WverifiedSubunit of the tRNA splicing endonuclease, which is composed ofSen2p, Sen15p, Sen34p, and Sen54p; Sen34pcontains the active site for tRNA 3' splicesite cleavage and has similarity to Sen2p andto Archaeal tRNA splicing endonuclease &radic0.334050.67522&radic&radic&radic&radic&radic S000003238PRP18YGR006WverifiedSplicing factor involved in the positioning of the 3' splicesite during the second catalytic step ofsplicing, recruited to the spliceosome by Slu7p &radic0.311510.64513&radic&radic S000007273BI4Q0120verifiedMitochondrial mRNA maturase, forms a complex with Nam2p tomediate splicing of the bI4 intron of the COBgene; encoded by both exon and intron sequencesof partially processed COB mRNA &radic0.305250.63892 S000007272BI3Q0115verifiedMitochondrial mRNA maturase, forms a complex with Mrs1p tomediate splicing of the bI3 intron of the COBgene; encoded by both exon and intron sequencesof partially processed COB mRNA &radic0.300120.63278 S000000614MAK31YCR020C-AverifiedNon-catalytic subunit of N-terminal acetyltransferase of theNatC type; required for replication of dsRNAvirus; member of the Sm protein family 0.296890.62808&radic&radic&radic S000002367NHP2YDL208WverifiedNuclear protein related to mammalian high mobility group (HMG)proteins, essential for function of H/ACA-typesnoRNPs, which are involved in 18S rRNAprocessing 0.293440.62447&radic S000002209LHP1YDL051WverifiedRNA binding protein required for maturation of tRNA and snRNAprecursors; acts as a molecular chaperone forRNAs transcribed by polymerase III; homologousto human La (SS-B) autoantigen 0.283610.61346&radic S000003450CRM1YGR218WverifiedMajor karyopherin, involved in export of proteins, RNAs, andribosomal subunits from the nucleus 0.277660.60621&radic&radic&radic&radic S000004339KAP95YLR347CverifiedKaryopherin beta, forms a dimeric complex with Srp1p (Kap60p)that mediates nuclear import of cargo proteinsvia a nuclear localization signal (NLS),interacts with nucleoporins to guide transportacross the nuclear pore complex 0.27090.5979 S000007260COX1Q0045verifiedSubunit I of cytochrome c oxidase, which is the terminal memberof the mitochondrial inner membrane electrontransport chain; one of threemitochondrially-encoded subunits 0.268660.59539 S000002691GCN2YDR283CverifiedProtein kinase, phosphorylates the alpha-subunit of translationinitiation factor eIF2 (Sui2p) in response tostarvation; activated by uncharged tRNAs andthe Gcn1p-Gcn20p complex 0.258390.58184&radic&radic&radic&radic&radic S000004903HAS1YMR290CverifiedATP-dependent RNA helicase; localizes to both the nuclearperiphery and nucleolus; highly enriched innuclear pore complex fractions; constituent of66S pre-ribosomal particles 0.25750.58114&radic S000001557MUD2YKL074CverifiedProtein involved in early pre-mRNA splicing; component of thepre-mRNA-U1 snRNP complex, the commitmentcomplex; interacts with Msl5p/BBP splicingfactor and Sub2p; similar to metazoan splicingfactor U2AF65 &radic0.252050.57428&radic&radic&radic&radic&radic&radic S000002633HTA1YDR225WverifiedOne of two nearly identical (see also HTA2) histone H2Asubtypes; core histone required for chromatinassembly and chromosome function; DNAdamage-dependent phosphorylation by Mec1pfacilitates DNA repair; acetylated by Nat4p 0.248410.56769&radic&radic&radic&radic S000003017TIF4632YGL049CverifiedTranslation initiation factor eIF4G, subunit of the mRNAcap-binding protein complex (eIF4F) that alsocontains eIF4E (Cdc33p); associates with thepoly(A)-binding protein Pab1p, also interactswith eIF4A (Tif1p); homologous to Tif4631p 0.243760.56103&radic S000005493HRT1YOL133WverifiedRING finger containing subunit of Skp1-Cullin-F-box ubiquitinprotein ligases (SCF); required for Gic2p,Far1p, Sic1p and Cln2p degradation; may tetherCdc34p (a ubiquitin conjugating enzyme or E2)and Cdc53p (a cullin) subunits of SCF 0.238570.55348&radic S000000752SNU13YEL026WverifiedRNA binding protein, part of U3 snoRNP involved in rRNAprocessing, part of U4/U6-U5 tri-snRNP involvedin mRNA splicing, similar to human 15.5Kprotein &radic0.216620.52387&radic&radic&radic S000004239YEF3YLR249WverifiedTranslational elongation factor, stimulates the binding ofaminoacyl-tRNA (AA-tRNA) to ribosomes byreleasing EF-1 alpha from the ribosomalcomplex; contains two ABC cassettes; binds andhydrolyses ATP 0.215270.5214&radic&radic&radic S000004064BUD20YLR074CverifiedProtein involved in bud-site selection; diploid mutants displaya random budding pattern instead of thewild-type bipolar pattern 0.211790.51593&radic S000005686MTR10YOR160WverifiedNuclear import receptor, mediates the nuclear localization ofproteins involved in mRNA-nucleus export 0.206240.50635&radic&radic&radic&radic S000004173TOS4YLR183CverifiedTranscription factor that binds to a number of promoterregions, particularly promoters of some genesinvolved in pheromone response and cell cycle;potential Cdc28p substrate; expression isinduced in G1 by bound SBF 0.202540.50063&radic&radic&radic S000004487YML6YML025CverifiedMitochondrial ribosomal protein of the large subunit, hassimilarity to E. coli L4 ribosomal protein andhuman mitoribosomal MRP-L4 protein; essentialfor viability, unlike most other mitoribosomalproteins 0.202590.50063&radic S000002334AIR2YDL175CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p; may regulatemethylation of Npl3p, which modulates Npl3pfunction in mRNA processing and export; hassimilarity to Air1p 0.202310.50029&radic S000000441PRP5YBR237WverifiedRNA helicase in the DEAD-box family, necessary forprespliceosome formation, bridges U1 and U2snRNPs and enables stable U2 snRNP associationwith intron RNA &radic0.20110.49847&radic&radic&radic&radic&radic&radic S000000564KRR1YCL059CverifiedEssential nucleolar protein required for the synthesis of 18SrRNA and for the assembly of 40S ribosomalsubunit 0.197360.49142&radic&radic&radic S000001732DBP7YKR024CverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in ribosomal biogenesis 0.196760.49048&radic S000006156RVB2YPL235WverifiedEssential protein involved in transcription regulation;component of chromatin remodeling complexes;required for assembly and function of the INO80complex; member of the RUVB-like protein family 0.195870.48896&radic&radic&radic S000003616SCP160YJL080CverifiedEssential RNA-binding G protein effector of mating responsepathway, predominantly associated with nuclearenvelope and ER, interacts in mRNA-dependentmanner with translating ribosomes via multipleKH domains, similar to vertebrate vigilins 0.195520.48835 S000003577NSP1YJL041WverifiedEssential component of the nuclear pore complex, which mediatesnuclear import and export 0.194040.48594 S000005230CUS2YNL286WverifiedProtein that binds to U2 snRNA and Prp11p, may be involved inU2 snRNA folding; contains two RNA recognitionmotifs (RRMs) &radic0.188810.4783&radic&radic&radic S000004106MSL5YLR116WverifiedComponent of the commitment complex, which defines the firststep in the splicing pathway; essential proteinthat interacts with Mud2p and Prp40p, forming abridge between the intron ends; also involvedin nuclear retention of pre-mRNA &radic0.187790.47622&radic&radic&radic&radic&radic&radic S000000455MRPS5YBR251WverifiedMitochondrial ribosomal protein of the small subunit 0.185620.47235&radic&radic&radic S000005896RPS12YOR369CverifiedProtein component of the small (40S) ribosomal subunit; hassimilarity to rat ribosomal protein S12 0.18090.46457&radic S000001444IST3YIR005WverifiedComponent of the U2 snRNP, required for the first catalyticstep of splicing and for spliceosomal assembly;interacts with Rds3p and is required forMer1p-activated splicing &radic0.179990.46315&radic&radic&radic S000003674TIF2YJL138CverifiedTranslation initiation factor eIF4A, identical to Tif1p;DEA(D/H)-box RNA helicase that couples ATPaseactivity to RNA binding and unwinding; forms adumbbell structure of two compact domainsconnected by a linker; interacts with eIF4G 0.179850.46264&radic&radic S000000063NUP60YAR002WverifiedSubunit of the nuclear pore complex (NPC), functions to anchorNup2p to the NPC in a process controlled by thenucleoplasmic concentration of Gsp1p-GTP;potential Cdc28p substrate; involved intelomere maintenance 0.177290.45868&radic&radic&radic&radic S000004431MRPL4YLR439WverifiedMitochondrial ribosomal protein of the large subunit 0.172160.44886&radic&radic&radic S000001341AIR1YIL079CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p to regulate methylationof Npl3p, which modulates Npl3p function inmRNA processing and export; has similarity toAir2p 0.169970.44535&radic&radic&radic&radic S000002789YRA1YDR381WverifiedNuclear protein that binds to RNA and to Mex67p, required forexport of poly(A)+ mRNA from the nucleus;member of the REF (RNA and export factorbinding proteins) family; another familymember, Yra2p, can substitute for Yra1pfunction 0.168450.4425&radic&radic S000002730MRPL35YDR322WverifiedMitochondrial ribosomal protein of the large subunit 0.15910.42527&radic&radic&radic&radic S000000808NUG1YER006WverifiedGTPase that associates with nuclear 60S pre-ribosomes, requiredfor export of 60S ribosomal subunits from thenucleus 0.157430.42218&radic&radic&radic S000001653MRPL38YKL170WverifiedMitochondrial ribosomal protein of the large subunit; appearsas two protein spots (YmL34 and YmL38) ontwo-dimensional SDS gels 0.15540.41811&radic&radic S000001767TIF1YKR059WverifiedTranslation initiation factor eIF4A, identical to Tif2p;DEA(D/H)-box RNA helicase that couples ATPaseactivity to RNA binding and unwinding; forms adumbbell structure of two compact domainsconnected by a linker; interacts with eIF4G 0.15410.4153&radic S000000128HEK2YBL032WverifiedRNA binding protein with similarity to hnRNP-K that localizesto the cytoplasm and to subtelomeric DNA;required for the proper localization of ASH1mRNA; involved in the regulation of telomereposition effect and telomere length 0.153840.41493&radic&radic S000005572DBP5YOR046CverifiedCytoplasmic ATP-dependent RNA helicase of the DEAD-box familyinvolved in mRNA export from the nucleus 0.153310.41416&radic S000004401UTP21YLR409CuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.152660.41273&radic&radic&radic&radic&radic S000005730DED1YOR204WverifiedATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, requiredfor translation initiation of all yeast mRNAs;mutations in human DEAD-box DBY are a frequentcause of male infertility &radic0.152570.41253&radic&radic S000003046DBP3YGL078CverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in ribosomal biogenesis 0.151620.41123&radic&radic&radic S000005168SQS1YNL224CverifiedProtein of unknown function; overexpression antagonizes thesuppression of splicing defects by spp382mutants; green fluorescent protein (GFP)-fusionprotein localizes to both the cytoplasm and thenucleus 0.150870.41018&radic&radic&radic&radic S000001894SPB4YFL002CverifiedPutative ATP-dependent RNA helicase, nucleolar protein requiredfor synthesis of 60S ribosomal subunits at alate step in the pathway; sediments with 66Spre-ribosomes in sucrose gradients 0.150430.40922&radic&radic S000000226POA1YBR022WverifiedPhosphatase that is highly specific for ADP-ribose1''-phosphate, a tRNA splicing metabolite; mayhave a role in regulation of tRNA splicing &radic0.14640.40139 S000005527RRP6YOR001WverifiedExonuclease component of the nuclear exosome; contributes tothe quality-control system that retains anddegrades aberrant mRNAs in the nucleus 0.145510.39947&radic&radic&radic&radic S000002837TIF35YDR429CverifiedSubunit of the core complex of translation initiation factor3(eIF3), which is essential for translation 0.144510.3977&radic&radic&radic S000003361SYF2YGR129WverifiedComponent of the spliceosome complex involved in pre-mRNAsplicing; involved in regulation of cell cycleprogression &radic0.143270.39547&radic&radic&radic&radic&radic S000002870MRPL28YDR462WverifiedMitochondrial ribosomal protein of the large subunit 0.142450.39328&radic S000001107RRP3YHR065CverifiedProtein involved in rRNA processing; required for maturation ofthe 35S primary transcript of pre-rRNA and forcleavage leading to mature 18S rRNA; homologousto eIF-4a, which is a DEAD box RNA-dependentATPase with helicase activity 0.140580.38999&radic&radic&radic&radic S000000870MOT2YER068WverifiedComponent of the CCR4-NOT complex, which has multiple roles intranscription regulation, mRNA degradation, andpost-transcriptional modifications; with Ubc4p,ubiquitylates subunits of the nascentpolypeptide-associated complex (NAC) 0.139650.38815&radic&radic S000004626MRPL3YMR024WverifiedMitochondrial ribosomal protein of the large subunit 0.137340.38434&radic S000000642IMG1YCR046CverifiedMitochondrial ribosomal protein of the large subunit, requiredfor respiration and for maintenance of themitochondrial genome 0.136710.38321&radic S000001697YRA2YKL214CverifiedMember of the REF (RNA and export factor binding proteins)family; when overexpressed, can substitute forthe function of Yra1p in export of poly(A)+mRNA from the nucleus 0.135630.38124&radic&radic S000003599MRPL8YJL063CverifiedMitochondrial ribosomal protein of the large subunit 0.134690.3791&radic S000002923SLF1YDR515WverifiedRNA binding protein that associates with polysomes; proposed tobe involved in regulating mRNA translation;involved in the copper-dependent mineralizationof copper sulfide complexes on cell surface incells cultured in copper salts 0.13450.37873 S000001877GNA1YFL017CverifiedEvolutionarily conserved glucosamine-6-phosphateacetyltransferase required for multiple cellcycle events including passage through START,DNA synthesis, and mitosis; involved inUDP-N-acetylglucosamine synthesis, formsGlcNAc6P from AcCoA 0.133740.37702&radic&radic&radic&radic&radic S000007271BI2Q0110verifiedMitochondrial mRNA maturase with a role in splicing, encoded byboth exon and intron sequences of partiallyprocessed COB mRNA &radic0.133250.37642 S000003803NUP85YJR042WverifiedSubunit of the Nup84p subcomplex of the nuclear pore complex(NPC), required for assembly of the subcomplexand also for formation of the nucleocytoplasmicGsp1p concentration gradient that plays a rolein nuclear trafficking 0.132230.37416&radic S000004950MRP7YNL005CverifiedMitochondrial ribosomal protein of the large subunit 0.13170.37336&radic S000002545HPR1YDR138WverifiedSubunit of THO/TREX complexes that couple transcriptionelongation with mitotic recombination and withmRNA metabolism and export, subunit of an RNAPol II complex; regulates lifespan; involved intelomere maintenance; similar to Top1p 0.130740.37148&radic&radic&radic&radic S000004735ECM16YMR128WverifiedEssential DEAH-box ATP-dependent RNA helicase specific to theU3 snoRNP, predominantly nucleolar indistribution, required for 18S rRNA synthesis 0.128590.36716&radic&radic&radic S000000346MAK5YBR142WverifiedEssential nucleolar protein, putative DEAD-box RNA helicaserequired for maintenance of M1 dsRNA virus;involved in biogenesis of large (60S) ribosomalsubunits 0.128180.36611&radic&radic&radic S000007261AI1Q0050verifiedReverse transcriptase required for splicing of the COX1pre-mRNA, encoded by a mobile group II intronwithin the mitochondrial COX1 gene 0.127460.36455 S000000542SRO9YCL037CverifiedCytoplasmic RNA-binding protein that associates withtranslating ribosomes; involved in hemeregulation of Hap1p as a component of the HMCcomplex, also involved in the organization ofactin filaments; contains a La motif 0.126480.3626&radic S000007263AI3Q0060verifiedEndonuclease I-SceIII, encoded by a mobile group I intronwithin the mitochondrial COX1 gene 0.12540.36026 S000004411YLR419WUncharacterizedPutative helicase with limited sequence similarity to human Rb protein; localized to the cytoplasm and the mitochondria; YLR419W is not an essential gene 0.125060.35965&radic&radic&radic S000004693YMR087WVerifiedPutative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain &radic0.123310.35634&radic&radic&radic&radic S000003454PET54YGR222WverifiedProtein required for splicing of the COX1 intron AI5 beta; alsospecifically required, together with Pet122pand Pet494p, for translation of the COX3 mRNA;located in the mitochondrial inner membrane &radic0.122870.35544&radic&radic&radic&radic&radic S000002242SUB2YDL084WverifiedComponent of the TREX complex required for nuclear mRNA export;member of the DEAD-box RNA helicase superfamilyand is involved in early and late steps ofspliceosome assembly; homolog of the humansplicing factor hUAP56 &radic0.120950.35083&radic S000001901SAD1YFR005CverifiedConserved zinc-finger domain protein involved in pre-mRNAsplicing, required for assembly of U4 snRNAinto the U4/U6 particle &radic0.120140.34959&radic&radic&radic&radic&radic&radic S000004685NAM7YMR080CverifiedATP-dependent RNA helicase of the SFI superfamily, required fornonsense mediated mRNA decay and for efficienttranslation termination at nonsense codons;involved in telomere maintenance 0.118040.34454&radic S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling 0.117410.34349&radic&radic&radic&radic&radic&radic S000002749YDR341CVerifiedCytoplasmic arginyl-tRNA synthetase 0.117140.34279&radic&radic S000003931DRS1YLL008WverifiedNucleolar DEAD-box protein required for ribosome assembly andfunction, including synthesis of 60S ribosomalsubunits; constituent of 66S pre-ribosomalparticles 0.116750.34206&radic S000007282Q0255UncharacterizedHypothetical protein 0.115530.33958 S000005837NOP58YOR310CverifiedProtein involved in pre-rRNA processing, 18S rRNA synthesis,and snoRNA synthesis; component of the smallsubunit processome complex, which is requiredfor processing of pre-18S rRNA 0.114460.33719&radic&radic S000000673PAT1YCR077CverifiedTopoisomerase II-associated deadenylation-dependentmRNA-decapping factor; also required forfaithful chromosome transmission, maintenanceof rDNA locus stability, and protection of mRNA3'-UTRs from trimming; functionally linked toPab1p 0.114330.337 S000004187SIK1YLR197WverifiedEssential evolutionarily-conserved nucleolar protein componentof the box C/D snoRNP complexes that direct2'-O-methylation of pre-rRNA during itsmaturation; overexpression causes spindleorientation defects 0.114270.33682&radic S000003955YLL032CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene 0.114220.33669 S000004125SLX4YLR135WverifiedSubunit of a complex, with Slx1p, that hydrolyzes 5' branchesfrom duplex DNA in response to stalled orconverging replication forks; function overlapswith that of Sgs1p-Top3p 0.112930.3336&radic S000003220HFM1YGL251CverifiedMeiosis specific DNA helicase involved in the conversion ofdouble-stranded breaks to later recombinationintermediates and in crossover control;catalyzes the unwinding of Holliday junctions;has ssDNA and dsDNA stimulated ATPase activity 0.11240.33269&radic&radic S000003503SLH1YGR271WverifiedPutative RNA helicase related to Ski2p, involved in translationinhibition of non-poly(A) mRNAs; required forrepressing propagation of dsRNA viruses 0.11190.33132&radic&radic S000005888PRT1YOR361CverifiedSubunit of the core complex of translation initiation factor3(eIF3), essential for translation; part of asubcomplex (Prt1p-Rpg1p-Nip1p) that stimulatesbinding of mRNA and tRNA(i)Met to ribosomes 0.110110.32692&radic&radic S000001561DHR2YKL078WverifiedPredominantly nucleolar DEAH-box RNA helicase, required for 18SrRNA synthesis 0.109650.3261&radic&radic&radic S000006259SEC8YPR055WverifiedEssential 121kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which has the essential function ofmediating polarized targeting of secretoryvesicles to active sites of exocytosis 0.109330.32523&radic&radic&radic S000000307SIF2YBR103WverifiedWD40 repeat-containing subunit of the Set3C histone deacetylasecomplex, which represses early/middlesporulation genes; antagonizes telomericsilencing; binds specifically to the Sir4pN-terminus 0.109060.32464&radic&radic&radic S000004266DBP9YLR276CverifiedATP-dependent RNA helicase of the DEAD-box family involved inbiogenesis of the 60S ribosomal subunit 0.108440.32333&radic S000001330SEC6YIL068CverifiedEssential 88kDa subunit of the exocyst complex, which mediatespolarized targeting of secretory vesicles toactive sites of exocytosis; dimeric form ofSec6p interacts with Sec9p in vitro andinhibits t-SNARE assembly 0.10760.32103&radic&radic S000004722ASC1YMR116CverifiedWD repeat protein (G-beta like protein) involved in translationregulation; required for repression of Gcn4pactivity in the absence of amino-acidstarvation; core component of the ribosome;ortholog of mammalian RACK1 0.106220.31835 S000005195NRD1YNL251CverifiedRNA-binding protein that interacts with the C-terminal domainof the RNA polymerase II large subunit(Rpo21p), required for transcriptiontermination and 3' end maturation ofnonpolyadenylated RNAs 0.104040.31299&radic&radic S000006111NAB3YPL190CverifiedSingle stranded DNA binding protein; acidic ribonucleoprotein;required for termination of non-poly(A)transcripts and efficient splicing; interactswith Nrd1p 0.103360.31098&radic&radic S000006132NIP7YPL211WverifiedNucleolar protein required for 60S ribosome subunit biogenesis,constituent of 66S pre-ribosomal particles;physically interacts with Nop8p and the exosomesubunit Rrp43p 0.100290.30337&radic&radic&radic&radic&radic&radic S000005336NOG2YNR053CverifiedPutative GTPase that associates with pre-60S ribosomal subunitsin the nucleolus and is required for theirnuclear export and maturation 0.10.3026&radic S000002274NUP84YDL116WverifiedSubunit of the nuclear pore complex (NPC), forms a subcomplexwith Nup85p, Nup120p, Nup145p-C, Sec13p, andSeh1p that plays a role in nuclear mRNA exportand NPC biogenesis 0.098020.29754 S000006040DBP1YPL119CverifiedPutative ATP-dependent RNA helicase of the DEAD-box proteinfamily; mutants show reduced stability of the40S ribosomal subunit scanning through 5'untranslated regions of mRNAs 0.096690.29451 S000003664PBS2YJL128CverifiedMAP kinase kinase that plays a pivotal role in the osmosensingsignal-transduction pathway, activated undersevere osmotic stress 0.096230.29336&radic&radic&radic S000005119NOP13YNL175CverifiedProtein of unknown function, localizes to the nucleolus andnucleoplasm; contains an RNA recognition motif(RRM) and has similarity to Nop12p, which isrequired for processing of pre-18S rRNA 0.093610.2858&radic&radic S000005199GIS2YNL255CverifiedProtein with seven cysteine-rich CCHC zinc-finger motifs,similar to human CNBP, proposed to be involvedin the RAS/cAMP signaling pathway 0.093230.28483&radic S000000452HIS7YBR248CverifiedImidazole glycerol phosphate synthase (glutamineamidotransferase:cyclase), catalyzes the fifthand sixth steps of histidine biosynthesis andalso produces 5-aminoimidazole-4-carboxamideribotide (AICAR), a purine precursor 0.092830.28368&radic&radic&radic S000005504NOP8YOL144WverifiedNucleolar protein required for 60S ribosomal subunit biogenesis 0.092050.28178&radic&radic S000003512PXR1YGR280CverifiedEssential protein involved in rRNA and snoRNA maturation;competes with TLC1 RNA for binding to Est2p,suggesting a role in regulation of telomerase;human homolog inhibits telomerase; contains aG-patch RNA interacting domain 0.091270.27965 S000005471MDY2YOL111CverifiedProtein required for efficient mating; involved in shmooformation and nuclear migration in thepre-zygote; associates with ribosomes andinteracts with YOR164C; contains aubiquitin-like (UBL) domain 0.089350.27428 S000004652ERB1YMR049CverifiedProtein required for maturation of the 25S and 5.8S ribosomalRNAs; constituent of 66S pre-ribosomalparticles; homologous to mammalian Bop1 0.08920.27391&radic S000002172NOP1YDL014WverifiedNucleolar protein, component of the small subunit processomecomplex, which is required for processing ofpre-18S rRNA; has similarity to mammalianfibrillarin 0.089160.27379 S000004490TSA1YML028WverifiedUbiquitous housekeeping thioredoxin peroxidase, reducesreactive oxygen, nitrogen and sulfur speciesusing thioredoxin as hydrogen donor; mediatesredox regulation of the nuclear localization ofYap1p; deletion results in mutator phenotype 0.088950.27333&radic S000004261YLR271WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YLR271W is not an essential gene 0.088050.27071&radic&radic&radic S000000437PBP2YBR233WverifiedRNA binding protein with similarity to mammalian heterogeneousnuclear RNP K protein, involved in theregulation of telomere position effect andtelomere length 0.087720.2699&radic S000003570HCA4YJL033WverifiedPutative nucleolar DEAD box RNA helicase; high-copy numbersuppression of a U14 snoRNA processing mutantsuggests an involvement in 18S rRNA synthesis 0.087680.2699 S000003586MTR4YJL050WverifiedDead-box family ATP dependent helicase required for mRNA exportfrom the nucleus; co-factor of the exosomecomplex, required for 3' end formation of 5.8SrRNA 0.086720.2675&radic&radic&radic&radic&radic S000000383FZO1YBR179CverifiedMitochondrial integral membrane protein involved inmitochondrial fusion and maintenance of themitochondrial genome; contains N-terminalGTPase domain 0.085610.26437&radic&radic S000004165CBF5YLR175WverifiedPseudouridine synthase catalytic subunit of box H/ACA smallnucleolar ribonucleoprotein particles(snoRNPs), acts on both large and small rRNAsand on snRNA U2 0.085840.26437&radic&radic&radic&radic&radic S000004156SEC10YLR166CverifiedEssential 100kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which has the essential function ofmediating polarized targeting of secretoryvesicles to active sites of exocytosis 0.085210.26339&radic&radic S000004006PML1YLR016CverifiedSubunit of the RES complex, which is required for nuclearretention of unspliced pre-mRNAs; acts in thesame pathway as Pml39p and Mlp1p &radic0.084960.26265&radic&radic S000002743MSN5YDR335WverifiedKaryopherin involved in nuclear import and export; shown to beresponsible for nuclear import of replicationprotein A and for export of several proteinsincluding Swi6p, Far1p, and Pho4p; cargodissociation involves binding to RanGTP 0.084720.2621&radic&radic S000001002YHL010CUncharacterizedPutative protein of unknown function, contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences 0.084580.26179&radic&radic&radic S000004836UBP8YMR223WverifiedUbiquitin-specific protease that is a component of the SAGA(Spt-Ada-Gcn5-Acetyltransferase) acetylationcomplex; required for SAGA-mediateddeubiquitination of histone H2B 0.084330.26092&radic&radic&radic S000000517GBP2YCL011CverifiedPoly(A+) RNA-binding protein, involved in the export of mRNAsfrom the nucleus to the cytoplasm; similar toHrb1p and Npl3p; also binds single-strandedtelomeric repeat sequence in vitro 0.084210.26065&radic&radic&radic S000002487VPS41YDR080WverifiedVacuolar membrane protein that is a subunit of the homotypicvacuole fusion and vacuole protein sorting(HOPS) complex; essential for membrane dockingand fusion at the Golgi-to-endosome andendosome-to-vacuole stages of protein transport 0.083320.25808&radic&radic&radic S000005122RPS3YNL178WverifiedProtein component of the small (40S) ribosomal subunit, hasapurinic/apyrimidinic (AP) endonucleaseactivity; essential for viability; hassimilarity to E. coli S3 and rat S3 ribosomalproteins 0.082760.25658&radic&radic S000007264AI4Q0065verifiedEndonuclease I-SceII, encoded by a mobile group I intron withinthe mitochondrial COX1 gene; intron is normallyspliced by the BI4p maturase but AI4p canmutate to acquire the same maturase activity &radic0.082660.25651 S000003410PBP1YGR178CverifiedProtein interacting with poly(A)-binding protein Pab1p; likelyinvolved in controlling the extent of mRNApolyadenylation; forms a complex with Mkt1pthat may regulate HO translation; interactswith Lsm12p in a copurification assay 0.08130.25247&radic S000004327NUP2YLR335WverifiedProtein involved in nucleocytoplasmic transport, binds toeither the nucleoplasmic or cytoplasmic facesof the nuclear pore complex depending onRan-GTP levels; also has a role in chromatinorganization 0.080160.24943&radic S000005768SSP2YOR242CverifiedSporulation specific protein that localizes to the spore wall;required for sporulation at a point aftermeiosis II and during spore wall formation;SSP2 expression is induced midway in meiosis 0.080060.24923 S000001380RHO3YIL118WverifiedNon-essential small GTPase of the Rho/Rac subfamily of Ras-likeproteins involved in the establishment of cellpolarity; GTPase activity positively regulatedby the GTPase activating protein (GAP) Rgd1p 0.079940.24889&radic&radic&radic S000001297CKA1YIL035CverifiedAlpha catalytic subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA2, CKB1 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.079880.24877&radic&radic&radic&radic&radic&radic S000002573SEC5YDR166CverifiedEssential 107kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which has the essential function ofmediating polarized targeting of secretoryvesicles to active sites of exocytosis 0.079720.24814&radic&radic&radic&radic&radic S000003149GTS1YGL181WverifiedProtein containing a zinc-finger in the N-terminus and a longGln-rich region in the C-terminus; regulatesultradian rhythm, cell size, cell cycle,lifespan, sporulation, heat tolerance, andmultidrug transport 0.079390.24719&radic S000002918SMT3YDR510WverifiedUbiquitin-like protein of the SUMO family, conjugated to lysineresidues of target proteins; regulateschromatid cohesion, chromosome segregation,APC-mediated proteolysis, DNA replication andseptin ring dynamics 0.079190.24668&radic S000003968RPL8BYLL045CverifiedRibosomal protein L4 of the large (60S) ribosomal subunit,nearly identical to Rpl8Ap and has similarityto rat L7a ribosomal protein; mutation resultsin decreased amounts of free 60S subunits 0.078570.24516&radic&radic S000001547MNR2YKL064WverifiedPutative magnesium transporter; has similarity to Alr1p andAlr2p, which mediate influx of Mg2+ and otherdivalent cations 0.078170.24411&radic&radic S000005056DBP2YNL112WverifiedEssential ATP-dependent RNA helicase of the DEAD-box proteinfamily, involved in nonsense-mediated mRNAdecay and rRNA processing 0.077520.24233&radic S000001025RPL8AYHL033CverifiedRibosomal protein L4 of the large (60S) ribosomal subunit,nearly identical to Rpl8Bp and has similarityto rat L7a ribosomal protein; mutation resultsin decreased amounts of free 60S subunits 0.076910.24042&radic S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.076150.23847&radic&radic&radic&radic&radic S000004284GSP1YLR293CverifiedGTP binding protein (mammalian Ranp homolog) involved in themaintenance of nuclear organization, RNAprocessing and transport; regulated by Prp20p,Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p andKap95p; yeast Gsp2p homolog 0.075940.23798&radic&radic&radic&radic S000005062DCP2YNL118CverifiedCatalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex,which removes the 5' cap structure from mRNAsprior to their degradation; member of the Nudixhydrolase family 0.074930.23506 S000006365SGV1YPR161CverifiedCyclin (Bur2p)-dependent protein kinase that functions intranscriptional regulation; phosphorylates thecarboxy-terminal domain of Rpo21p, which is thelargest subunit of RNA polymerase II; regulatedby Cak1p 0.074920.23506&radic&radic&radic&radic S000001377NUP159YIL115CverifiedSubunit of the nuclear pore complex that is found exclusivelyon the cytoplasmic side, forms a subcomplexwith Nup82p and Nsp1p, required for mRNA export 0.074650.23431&radic&radic S000002831CAD1YDR423CverifiedAP-1-like bZIP transcriptional activator involved in multiplestress responses, iron metabolism, andpleiotropic drug resistance; controls a set ofgenes involved in stabilizing proteins, bindsconsensus sequence TTACTAA; 5' UTR containsuORFs 0.074420.23373&radic&radic&radic&radic S000001540NUP120YKL057CverifiedSubunit of the Nup84p subcomplex of the nuclear pore complex(NPC), required for even distribution of NPCsaround the nuclear envelope, involved inestablishment of a normal nucleocytoplasmicconcentration gradient of the GTPase Gsp1p 0.073930.23223&radic&radic S000007262AI2Q0055verifiedReverse transcriptase required for splicing of the COX1pre-mRNA, encoded by a mobile group II intronwithin the mitochondrial COX1 gene &radic0.073890.23223 S000001898NIC96YFR002WverifiedComponent of the nuclear pore complex, required for nuclearpore formation; forms a subcomplex with Nsp1p,Nup57p, and Nup49p 0.073660.23147 S000000264ORC2YBR060CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing; may be phosphorylated by Cdc28p 0.07330.23066&radic&radic&radic S000004422SEN1YLR430WverifiedPutative helicase required for RNA polymerase II transcriptiontermination and processing of RNAs; homolog ofSenataxin which causes Ataxia-OculomotorApraxia 2 and a dominant form of amyotrophiclateral sclerosis 0.072880.22962&radic S000003032MRH4YGL064CverifiedMitochondrial RNA helicase of the DEAD-box family, plays anessential role in mitochondrial function 0.072730.22932&radic S000005150RTT106YNL206CverifiedProtein with a role in regulation of Ty1 transposition 0.071750.22652&radic&radic S000002428FAL1YDR021WverifiedNucleolar protein required for maturation of 18S rRNA, memberof the eIF4A subfamily of DEAD-boxATP-dependent RNA helicases 0.071260.22512&radic&radic&radic&radic S000003139ROK1YGL171WverifiedATP-dependent RNA helicase of the DEAD box family; required for18S rRNA synthesis 0.071160.22489&radic&radic&radic&radic S000004802SGS1YMR190CverifiedNucleolar DNA helicase of the RecQ family involved inmaintenance of genome integrity, regulateschromosome synapsis and meiotic crossing over;has similarity to human BLM and WRN helicasesimplicated in Bloom and Werner syndromes 0.070980.2244&radic S000001026SBP1YHL034CverifiedNucleolar single-strand nucleic acid binding protein;associates with small nuclear RNAs 0.070090.22187&radic S000004103HOG1YLR113WverifiedMitogen-activated protein kinase involved in osmoregulation viathree independent osmosensors; mediates therecruitment and activation of RNA Pol II atHot1p-dependent promoters; localizationregulated by Ptp2p and Ptp3p 0.069830.22117&radic&radic S000000318RAD16YBR114WverifiedProtein that recognizes and binds damaged DNA in anATP-dependent manner (with Rad7p) duringnucleotide excision repair; subunit ofNucleotide Excision Repair Factor 4 (NEF4);member of the SWI/SNF family 0.069660.22036&radic S000000966CHD1YER164WverifiedNucleosome remodeling factor that functions in regulation oftranscription elongation; contains a chromodomain, a helicase domain and a DNA-bindingdomain; component of both the SAGA and SILKcomplexes 0.069380.21989&radic S000007279SCEIQ0160verifiedI-SceI DNA endonuclease, encoded by the mitochondrial group Iintron of the 21S_rRNA gene; mediates geneconversion that propagates the intron intointron-less copies of the 21S_rRNA gene 0.069150.21929 S000001133MSR1YHR091CverifiedMitochondrial arginyl-tRNA synthetase 0.068860.21831&radic&radic S000003131RAD54YGL163CverifiedDNA-dependent ATPase, stimulates strand exchange by modifyingthe topology of double-stranded DNA; involvedin the recombinational repair of double-strandbreaks in DNA during vegetative growth andmeiosis; member of the SWI/SNF family 0.068430.21696&radic S000002552TAF12YDR145WverifiedSubunit (61/68 kDa) of TFIID and SAGA complexes, involved inRNA polymerase II transcription initiation andin chromatin modification, similar to histoneH2A 0.068310.2169&radic&radic&radic S000000396RIM2YBR192WverifiedMitochondrial pyrimidine nucleotide transporter; importspyrimidine nucleoside triphosphates and exportspyrimidine nucleoside monophosphates; member ofthe mitochondrial carrier family 0.067610.21513&radic&radic&radic S000005933RRP12YPL012WverifiedProtein required for export of the ribosomal subunits;associates with the RNA components of thepre-ribosomes; contains HEAT-repeats 0.067380.21445&radic&radic&radic S000001635GPM1YKL152CverifiedTetrameric phosphoglycerate mutase, mediates the conversion of3-phosphoglycerate to 2-phosphoglycerate duringglycolysis and the reverse reaction duringgluconeogenesis 0.067110.2136&radic&radic&radic&radic&radic S000002483RAD55YDR076WverifiedProtein that stimulates strand exchange by stabilizing thebinding of Rad51p to single-stranded DNA;involved in the recombinational repair ofdouble-strand breaks in DNA during vegetativegrowth and meiosis; forms heterodimer withRad57p 0.066680.21227&radic&radic&radic&radic&radic S000001802RPL40BYKR094CverifiedFusion protein, identical to Rpl40Ap, that is cleaved to yieldubiquitin and a ribosomal protein of the large(60S) ribosomal subunit with similarity to ratL40; ubiquitin may facilitate assembly of theribosomal protein into ribosomes 0.066620.21214 S000000824SRB4YER022WverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation 0.066580.21199&radic&radic&radic&radic&radic&radic S000000159KIP1YBL063WverifiedKinesin-related motor protein required for mitotic spindleassembly and chromosome segregation;functionally redundant with Cin8p 0.066570.21199 S000003388PTI1YGR156WverifiedPta1p Interacting protein 0.066450.21166&radic&radic S000005433THP1YOL072WverifiedNuclear pore-associated protein, forms a complex with Sac3pthat is involved in transcription and in mRNAexport from the nucleus; contains a PAM domainimplicated in protein-protein binding 0.066330.21122&radic&radic S000003141KEM1YGL173CverifiedEvolutionarily-conserved 5'-3' exonuclease component ofcytoplasmic processing (P) bodies involved inmRNA decay; plays a role inmicrotubule-mediated processes, filamentousgrowth, ribosomal RNA maturation, and telomeremaintenance 0.06540.20883 S000004157RPS31YLR167WverifiedFusion protein that is cleaved to yield a ribosomal protein ofthe small (40S) subunit and ubiquitin;ubiquitin may facilitate assembly of theribosomal protein into ribosomes; interactsgenetically with translation factor eIF2B 0.065320.20851&radic&radic S000001790NUP133YKR082WverifiedSubunit of the Nup84p subcomplex of the nuclear pore complex(NPC), localizes to both sides of the NPC,required to establish a normalnucleocytoplasmic concentration gradient of theGTPase Gsp1p 0.065230.20831 S000002444KRS1YDR037WverifiedLysyl-tRNA synthetase; also identified as a negative regulatorof general control of amino acid biosynthesis 0.064390.20587&radic&radic&radic S000005981LPE10YPL060WverifiedMitochondrial inner membrane magnesium transporter, involved inmaintenance of magnesium concentrations insidemitochondria; indirectly affects splicing ofgroup II introns; functionally and structurallyrelated to Mrs2p 0.064380.20587&radic S000004172SWI6YLR182WverifiedTranscription cofactor, forms complexes with DNA-bindingproteins Swi4p and Mbp1p to regulatetranscription at the G1/S transition; involvedin meiotic gene expression; localizationregulated by phosphorylation; potential Cdc28psubstrate 0.064250.20525&radic&radic&radic&radic S000001212DBP8YHR169WverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in biogenesis of the 40S ribosomalsubunit 0.064110.20502&radic S000003482YGR250CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.063830.2043&radic&radic&radic S000002372NOP6YDL213CuncharacterizedProtein with similarity to hydrophilins, which are involved inthe adaptive response to hyperosmoticconditions; computational analysis oflarge-scale protein-protein interaction datasuggests a possible role in rRNA processing 0.063510.2033&radic&radic S000000393RPS9BYBR189WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps9Ap and has similarity to E.coli S4 and rat S9 ribosomal proteins 0.063060.20201&radic&radic S000005133SRP1YNL189WverifiedKaryopherin alpha homolog, forms a dimer with karyopherin betaKap95p to mediate import of nuclear proteins,binds the nuclear localization signal of thesubstrate during import; may also play a rolein regulation of protein degradation 0.063140.20201&radic S000005509DCP1YOL149WverifiedSubunit of the Dcp1p-Dcp2p decapping enzyme complex, whichremoves the 5' cap structure from mRNAs priorto their degradation; enhances the activity ofcatalytic subunit Dcp2p; regulated by DEAD boxprotein Dhh1p 0.063140.20201&radic&radic&radic&radic S000000810SEC3YER008CverifiedNon-essential subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, Exo84p)which mediates targeting of post-Golgi vesiclesto sites of active exocytosis; Sec3pspecifically is a spatial landmark forsecretion 0.063060.20201&radic&radic&radic S000004829SKY1YMR216CverifiedSR protein kinase (SRPK) involved in regulating proteinsinvolved in mRNA metabolism and cationhomeostasis; similar to human SRPK1 &radic0.063050.2019&radic&radic&radic S000005141WHI3YNL197CverifiedRNA binding protein that sequesters CLN3 mRNA in cytoplasmicfoci; cytoplasmic retention factor for Cdc28pand associated cyclins; regulates cell fate anddose-dependently regulates the critical cellsize required for passage through Start 0.062590.20063&radic&radic&radic&radic S000001441MPH1YIR002CverifiedMember of the DEAH family of helicases, functions in anerror-free DNA damage bypass pathway thatinvolves homologous recombination, mutationsconfer a mutator phenotype 0.062510.20029&radic S000000973RAD3YER171Wverified5' to 3' DNA helicase, involved in nucleotide excision repairand transcription; subunit of RNA polymerase IItranscription initiation factor TFIIH; subunitof Nucleotide Excision Repair Factor 3 (NEF3);homolog of human XPD protein 0.062230.19957&radic S000001844ALR2YFL050CverifiedProbable Mg(2+) transporter; overexpression confers increasedtolerance to Al(3+) and Ga(3+) ions 0.062080.19907 S000003207CSE1YGL238WverifiedNuclear envelope protein that mediates the nuclear export ofimportin alpha (Srp1p), homolog of metazoan CASprotein, required for accurate chromosomesegregation 0.061550.19733&radic&radic&radic&radic&radic&radic&radic S000005154MER1YNL210WverifiedProtein with RNA-binding motifs required for meiosis-specificmRNA splicing; required for chromosome pairingand meiotic recombination &radic0.061450.19701&radic&radic&radic&radic S000004410CDC73YLR418CverifiedConstituent of Paf1 complex with RNA polymerase II, Paf1p,Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinctfrom Srb-containing Pol II complexes; requiredfor expression of certain genes, modificationof some histones, and telomere maintenance 0.061440.19701&radic&radic&radic&radic&radic S000005321DBP6YNR038WverifiedEssential protein involved in ribosome biogenesis; putativeATP-dependent RNA helicase of the DEAD-boxprotein family 0.0610.19573&radic S000004216BUR2YLR226WverifiedCyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2pcomprise a CDK-cyclin complex involved intranscriptional regulation through itsphosphorylation of the carboxy-terminal domainof the largest subunit of RNA polymerase II 0.06020.19347&radic&radic&radic&radic S000002602MSS116YDR194CverifiedDEAD-box protein required for efficient splicing ofmitochondrial Group I and II introns; non-polarRNA helicase that also facilities strandannealing &radic0.059180.19039 S000005490ALR1YOL130WverifiedPlasma membrane Mg(2+) transporter, expression and turnover areregulated by Mg(2+) concentration;overexpression confers increased tolerance toAl(3+) and Ga(3+) ions 0.059160.19039 S000000262UBP14YBR058CverifiedUbiquitin-specific protease that specifically disassemblesunanchored ubiquitin chains; involved infructose-1,6-bisphosphatase (Fbp1p)degradation; similar to human isopeptidase T 0.059070.19023&radic S000002699HRQ1YDR291WuncharacterizedPutative DNA helicase 0.058870.18964&radic&radic S000002566SAC3YDR159WverifiedNuclear pore-associated protein, forms a complex with Thp1pthat is involved in transcription and in mRNAexport from the nucleus 0.058840.18949&radic&radic S000002189DBP10YDL031WverifiedPutative ATP-dependent RNA helicase of the DEAD-box proteinfamily, constituent of 66S pre-ribosomalparticles; essential protein involved inribosome biogenesis 0.058430.18823 S000001057MIP6YHR015WverifiedPutative RNA-binding protein, interacts with Mex67p, which is acomponent of the nuclear pore involved innuclear mRNA export 0.058020.18706&radic&radic&radic S000005964NOP4YPL043WverifiedNucleolar protein, essential for processing and maturation of27S pre-rRNA and large ribosomal subunitbiogenesis; constituent of 66S pre-ribosomalparticles; contains four RNA recognition motifs(RRMs) 0.057790.18635&radic&radic&radic S000002984KAP122YGL016WverifiedKaryopherin beta, responsible for import of the Toa1p-Toa2pcomplex into the nucleus; binds to nucleoporinsNup1p and Nup2p; may play a role in regulationof pleiotropic drug resistance 0.057680.18599&radic&radic&radic&radic S000001119NMD2YHR077CverifiedProtein involved in the nonsense-mediated mRNA decay (NMD)pathway; interacts with Nam7p and Upf3p;involved in telomere maintenance 0.05760.18575&radic S000000909GLE2YER107CverifiedComponent of the nuclear pore complex required forpolyadenylated RNA export but not for proteinimport, homologous to S. pombe Rae1p 0.057550.1856 S000000329PTC4YBR125CverifiedCytoplasmic type 2C protein phosphatase; identified as ahigh-copy number suppressor of the syntheticlethality of a cnb1 mpk1 double deletion;overexpression decreases high-osmolarityinduced Hog1p phosphorylation and kinaseactivity 0.056780.1832 S000004310EST2YLR318WverifiedReverse transcriptase subunit of the telomerase holoenzyme,essential for telomerase core catalyticactivity, involved in other aspects oftelomerase assembly and function; mutations inhuman homolog are associated with aplasticanemia 0.056780.1832 S000005624NUP1YOR098CverifiedNuclear pore complex (NPC) subunit, involved in proteinimport/export and in export of RNAs, possiblekaryopherin release factor that acceleratesrelease of karyopherin-cargo complexes aftertransport across NPC; potential Cdc28psubstrate 0.056690.18298&radic S000001542MPE1YKL059CverifiedEssential conserved subunit of CPF (cleavage andpolyadenylation factor), plays a role in 3' endformation of mRNA via the specific cleavage andpolyadenylation of pre-mRNA, contains aputative RNA-binding zinc knuckle motif 0.056380.18221&radic&radic&radic S000002366GLE1YDL207WverifiedCytoplasmic nucleoporin required for polyadenylated RNA exportbut not for protein import; component of Nup82pnuclear pore subcomplex; contains a nuclearexport signal 0.0560.18111&radic&radic S000002466UBC5YDR059CverifiedUbiquitin-conjugating enzyme that mediates selectivedegradation of short-lived and abnormalproteins, central component of the cellularstress response; expression is heat inducible 0.05590.18086&radic&radic S000000891PTC2YER089CverifiedType 2C protein phosphatase; dephosphorylates Hog1p to limitmaximal osmostress induced kinase activity;dephosphorylates Ire1p to downregulate theunfolded protein response; dephosphorylatesCdc28p; role in DNA checkpoint inactivation 0.055750.18031&radic S000001730NTR2YKR022CverifiedEssential protein that forms a dimer with Ntr1p; also forms atrimer, with Ntr2p and the DExD/H-box RNAhelicase Prp43p, that is involved inspliceosome disassembly &radic0.05570.18021&radic&radic&radic&radic&radic S000002771ESC2YDR363WverifiedProtein involved in mating-type locus silencing, interacts withSir2p; probably functions to recruit orstabilize Sir proteins 0.055430.17938&radic&radic S000003360UTP8YGR128CverifiedNucleolar protein required for export of tRNAs from thenucleus; also copurifies with the small subunit(SSU) processome containing the U3 snoRNA thatis involved in processing of pre-18S rRNA 0.054870.17783&radic&radic&radic&radic S000000464RGD1YBR260CverifiedGTPase-activating protein (RhoGAP) for Rho3p and Rho4p,possibly involved in control of actincytoskeleton organization 0.054930.17783 S000004305SPH1YLR313CverifiedProtein involved in shmoo formation and bipolar bud siteselection; homologous to Spa2p, localizes tosites of polarized growth in a cell cycledependent- and Spa2p-dependent manner,interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p 0.054890.17783&radic&radic&radic S000004494RAD52YML032CverifiedProtein that stimulates strand exchange by facilitating Rad51pbinding to single-stranded DNA; annealscomplementary single-stranded DNA; involved inthe repair of double-strand breaks in DNAduring vegetative growth and meiosis 0.054930.17783&radic&radic S000000883SER3YER081Wverified3-phosphoglycerate dehydrogenase, catalyzes the first step inserine and glycine biosynthesis; isozyme ofSer33p 0.054630.1772&radic&radic&radic&radic&radic S000002744YDR336WUncharacterizedPutative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene 0.053750.17486&radic&radic&radic&radic&radic&radic S000002740IRC3YDR332WuncharacterizedHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 0.053720.1748&radic&radic&radic&radic&radic S000003351NUP57YGR119CverifiedEssential subunit of the nuclear pore complex (NPC), functionsas the organizing center of an NPC subcomplexcontaining Nsp1p, Nup49p, Nup57p, and Nic96p 0.053580.17431&radic S000005616PTC5YOR090CverifiedMitochondrially localized type 2C protein phosphatase involvedin regulation of pyruvate dehydrogenaseactivity; contains Mg2+/Mn2+-dependent caseinphosphatase activity in vitro 0.053250.17335&radic S000004390SKI2YLR398CverifiedPutative RNA helicase, involved in exosome mediated 3' to 5'mRNA degradation and translation inhibition ofnon-poly(A) mRNAs; forms complex with Ski3p andSki8p; required for repressing propagation ofdsRNA viruses 0.05280.17206&radic S000004563VPS9YML097CverifiedA guanine nucleotide exchange factor involved invesicle-mediated vacuolar protein transport;specifically stimulates the intrinsic guaninenucleotide exchange activity of Vps21p/Rab5:similar to mammalian ras inhibitors; bindsubiquitin 0.052340.17053&radic&radic&radic&radic S000005475PAP2YOL115WverifiedCatalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), anuclear poly (A) polymerase complex involved inRNA quality control; catalyzes polyadenylationof unmodified tRNAs, and snoRNA and rRNAprecursors; disputed role as a DNA polymerase 0.052060.16984&radic&radic&radic&radic S000001056SPO13YHR014WverifiedMeiosis-specific protein, involved in maintaining sisterchromatid cohesion during meiosis I as well aspromoting proper attachment of kinetochores tothe spindle during meiosis I and meiosis II 0.051980.16964&radic&radic&radic S000000472MRPL37YBR268WverifiedMitochondrial ribosomal protein of the large subunit 0.051970.16958&radic S000001550YNK1YKL067WverifiedNucleoside diphosphate kinase, catalyzes the transfer of gammaphosphates from nucleoside triphosphates,usually ATP, to nucleoside diphosphates by amechanism that involves formation of anautophosphorylated enzyme intermediate 0.051930.16943&radic&radic S000004841MTF1YMR228WverifiedMitochondrial RNA polymerase specificity factor with structuralsimilarity to S-adenosylmethionine-dependentmethyltransferases and functional similarity tobacterial sigma-factors, interacts withmitochondrial core polymerase Rpo41p 0.051570.16848&radic&radic&radic&radic&radic S000000115APN2YBL019WverifiedClass II abasic (AP) endonuclease involved in repair of DNAdamage; homolog of human HAP1 and E. coliexoIII 0.051560.16846&radic&radic&radic&radic&radic&radic S000002501YDR094WDubiousHypothetical protein 0.051260.16739&radic S000001123LRP1YHR081WverifiedSubstrate-specific nuclear cofactor for exosome activity in theprocessing of stable RNAs; required fortelomere length maintenance; homolog ofmammalian nuclear matrix protein C1D involvedin regulation of DNA repair and recombination 0.050930.16612&radic S000005950SUV3YPL029WverifiedATP-dependent RNA helicase, component of the mitochondrialdegradosome along with the RNase Dss1p; thedegradosome associates with the ribosome andmediates turnover of aberrant or unprocessedRNAs 0.050770.16584&radic&radic S000003597NUP82YJL061WverifiedSubunit of the nuclear pore complex (NPC), forms a subcomplexwith Nup159p and Nsp1p, interacts with Nup116pand is required for proper localization ofNup116p in the NPC 0.050620.16538&radic&radic&radic S000000763RAD23YEL037CverifiedProtein with ubiquitin-like N terminus, recognizes and bindsdamaged DNA (with Rad4p) during nucleotideexcision repair; regulates Rad4p levels,subunit of Nuclear Excision Repair Factor 2(NEF2); homolog of human HR23A and HR23Bproteins 0.050540.16529&radic&radic&radic S000000147PIN4YBL051CverifiedProtein involved in G2/M phase progression and response to DNAdamage, interacts with Rad53p; contains an RNArecognition motif, a nuclear localizationsignal, and several SQ/TQ cluster domains;hyperphosphorylated in response to DNA damage 0.050460.16509&radic&radic&radic S000004223EST1YLR233CverifiedTLC1 RNA-associated factor involved in telomere lengthregulation as the recruitment subunit of thetelomerase holoenzyme, has a possible role inactivating Est2p-TLC1-RNA bound to the telomere 0.050190.16416&radic&radic S000005549AHC1YOR023CverifiedSubunit of the Ada histone acetyltransferase complex, requiredfor structural integrity of the complex 0.050130.16404&radic S000003202SEC15YGL233WverifiedEssential 113kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which mediates polarized targeting ofvesicles to active sites of exocytosis; Sec15passociates with Sec4p and vesicles 0.050080.1639&radic&radic&radic&radic S000005483HRP1YOL123WverifiedSubunit of cleavage factor I, a five-subunit complex requiredfor the cleavage and polyadenylation ofpre-mRNA 3' ends; RRM-containing heteronuclearRNA binding protein and hnRNPA/B family memberthat binds to poly (A) signal sequences 0.049790.16303&radic S000002546RUB1YDR139CverifiedUbiquitin-like protein with similarity to mammalian NEDD8;conjugation (neddylation) substrates includethe cullins Cdc53p, Rtt101p, and Cul3p;activated by Ula1p and Uba3p (E1 enzyme pair);conjugation mediated by Ubc12p (E2 enzyme) 0.04970.16277&radic&radic&radic&radic S000005543PET127YOR017WverifiedProtein with a role in mitochondrial RNA stability and/orprocessing, located in the mitochondrialmembrane 0.049640.16259&radic&radic S000000532FUS1YCL027WverifiedMembrane protein localized to the shmoo tip, required for cellfusion; expression regulated by matingpheromone; proposed to coordinate signaling,fusion, and polarization events required forfusion; potential Cdc28p substrate 0.049550.16225&radic&radic S000002326NRP1YDL167CverifiedProtein of unknown function, rich in asparagine residues 0.04940.16173&radic S000000449ISW1YBR245CverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPase thatforms a complex with Ioc2p and Ioc4p toregulate transcription elongation, and acomplex with Ioc3p to repress transcriptioninitiation 0.048980.1605&radic&radic S000000221KAP104YBR017CverifiedTransportin, cytosolic karyopherin beta 2 involved in deliveryof heterogeneous nuclear ribonucleoproteins tothe nucleoplasm, binds rg-nuclear localizationsignals on Nab2p and Hrp1p, plays a role incell-cycle progression 0.04870.15959&radic S000006129RKM1YPL208WverifiedSET-domain lysine-N-methyltransferase, catalyzes the formationof dimethyllysine residues on the largeribsomal subunit protein L23a (RPL23A andRPL23B) 0.048640.15939&radic&radic&radic S000001491LAC1YKL008CverifiedCeramide synthase component, involved in synthesis of ceramidefrom C26(acyl)-coenzyme A anddihydrosphingosine or phytosphingosine,functionally equivalent to Lag1p 0.04860.15925&radic&radic&radic&radic S000000702ADH7YCR105WverifiedNADPH-dependent cinnamyl alcohol dehydrogenase family memberwith broad substrate specificity; may beinvolved in fusel alcohol synthesis 0.04850.15888&radic S000000741EDC3YEL015WverifiedNon-essential conserved protein of unknown function, plays arole in mRNA decapping by specificallyaffecting the function of the decapping enzymeDcp1p; localizes to cytoplasmic mRNA processingbodies 0.048420.15864&radic&radic&radic&radic S000001891MSH4YFL003CverifiedProtein involved in meiotic recombination, required for normallevels of crossing over, colocalizes with Zip2pto discrete foci on meiotic chromosomes, hashomology to bacterial MutS protein 0.047990.15741&radic S000006337SPN1YPR133CverifiedProtein that interacts with Spt6p and copurifies with Spt5p andRNA polymerase II, probable transcriptionalelongation factor; metazoan homologs contain anacidic N terminus; mutations in the gene conferan Spt- phenotype 0.047910.15692&radic&radic S000003542CYR1YJL005WverifiedAdenylate cyclase, required for cAMP production andcAMP-dependent protein kinase signaling;involved in cell cycle control and glucose andnitrogen repression of sporulation 0.047610.15598 S000002709CFT1YDR301WverifiedRNA-binding subunit of the mRNA cleavage and polyadenylationfactor; involved in poly(A) site recognitionand required for both pre-mRNA cleavage andpolyadenylation, 51% sequence similarity withmammalian AAUAA-binding subunit of CPSF 0.047570.15593&radic&radic&radic S000004328SGD1YLR336CverifiedEssential nuclear protein with a possible role in theosmoregulatory glycerol response; interactswith phospholipase C (Plc1p); putative homologof human NOM1 which is implicated in acutemyeloid leukemia 0.047490.15559&radic&radic&radic S000005054NOP15YNL110CverifiedConstituent of 66S pre-ribosomal particles, involved in 60Sribosomal subunit biogenesis; localizes to bothnucleolus and cytoplasm 0.047430.15545&radic S000006311YTH1YPR107CverifiedEssential RNA-binding component of cleavage and polyadenylationfactor, contains five zinc fingers; requiredfor pre-mRNA 3'-end processing andpolyadenylation 0.047360.15502&radic&radic&radic S000004007MEU1YLR017WverifiedMethylthioadenosine phosphorylase (MTAP), catalyzes the initialstep in the methionine salvage pathway; affectspolyamine biosynthesis through regulation ofornithine decarboxylase (Spe1p) activity;regulates ADH2 gene expression 0.047390.15502&radic&radic&radic S000004093CDC45YLR103CverifiedDNA replication initiation factor; recruited to MCM pre-RCcomplexes at replication origins; promotesrelease of MCM from Mcm10p, recruits elongationmachinery; mutants in human homolog may causevelocardiofacial and DiGeorge syndromes 0.04680.15325&radic&radic S000004267YSH1YLR277CverifiedPutative endonuclease, subunit of the mRNA cleavage andpolyadenylation specificity complex requiredfor 3' processing of mRNAs 0.046750.15312&radic&radic&radic&radic&radic S000001049ERG11YHR007CverifiedLanosterol 14-alpha-demethylase, catalyzes the C-14demethylation of lanosterol to form4,4''-dimethylcholesta-8,14,24-triene-3-beta-ol in theergosterol biosynthesis pathway; member of thecytochrome P450 family 0.046380.152&radic&radic&radic S000003391NSR1YGR159CverifiedNucleolar protein that binds nuclear localization sequences,required for pre-rRNA processing and ribosomebiogenesis 0.046380.15189&radic&radic S000001692STE6YKL209CverifiedATP-binding cassette (ABC) transporter required for the exportof a-factor, catalyzes ATP hydrolysis coupledto a-factor transport, contains 12transmembrane domains and two ATP bindingdomains, expressed only in MATa cells 0.046350.15189&radic&radic S000005783CDC31YOR257WverifiedComponent of the spindle pole body (SPB) half-bridge, requiredfor SPB duplication in mitosis and meiosis II;homolog of mammalian centrin; interacts withKar1p 0.046330.15183&radic&radic&radic&radic&radic S000003962UBI4YLL039CverifiedUbiquitin, becomes conjugated to proteins, marking them forselective degradation via the ubiquitin-26Sproteasome system; essential for the cellularstress response 0.045960.15064&radic&radic S000001410RPL40AYIL148WverifiedFusion protein, identical to Rpl40Bp, that is cleaved to yieldubiquitin and a ribosomal protein of the large(60S) ribosomal subunit with similarity to ratL40; ubiquitin may facilitate assembly of theribosomal protein into ribosomes 0.045750.15007&radic S000005083RLR1YNL139CverifiedSubunit of the THO complex, which is required for efficienttranscription elongation and involved intranscriptional elongation-associatedrecombination; required for LacZ RNA expressionfrom certain plasmids 0.04570.14991&radic S000005146SPS19YNL202WverifiedPeroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme offatty acid beta-oxidation; homodimeric enzymerequired for growth and sporulation onpetroselineate medium; expression inducedduring late sporulation and in the presence ofoleate 0.045690.14984&radic S000002435REG1YDR028CverifiedRegulatory subunit of type 1 protein phosphatase Glc7p,involved in negative regulation ofglucose-repressible genes 0.045650.14972&radic&radic&radic S000003215RAI1YGL246CverifiedNuclear protein that binds to and stabilizes theexoribonuclease Rat1p, required for pre-rRNAprocessing 0.045670.14972&radic&radic&radic&radic&radic&radic&radic S000000671ERS1YCR075CverifiedProtein with similarity to human cystinosin, which is aH(+)-driven transporter involved in L-cystineexport from lysosomes and implicated in thedisease cystinosis; contains seventransmembrane domains 0.045650.14967 S000005649LEO1YOR123CverifiedComponent of the Paf1 complex, which associates with RNApolymerase II and is involved in histonemethylation 0.045630.14963&radic&radic&radic&radic&radic S000001490CAP1YKL007WverifiedAlpha subunit of the capping protein (CP) heterodimer (Cap1pand Cap2p) which binds to the barbed ends ofactin filaments preventing furtherpolymerization; localized predominantly tocortical actin patches 0.045520.14929&radic&radic&radic&radic S000000152PTC3YBL056WverifiedType 2C protein phosphatase; dephosphorylates Hog1p (see alsoPtc2p) to limit maximal kinase activity inducedby osmotic stress; dephosphorylates T169phosphorylated Cdc28p (see also Ptc2p); role inDNA checkpoint inactivation 0.045370.14885&radic&radic S000000967PAB1YER165WverifiedPoly(A) binding protein, part of the 3'-end RNA-processingcomplex, mediates interactions between the 5'cap structure and the 3' mRNA poly(A) tail,involved in control of poly(A) tail length,interacts with translation factor eIF-4G 0.045140.14807 S000002526YDR119WUncharacterizedHypothetical protein 0.045060.14771&radic&radic&radic&radic S000001526PHD1YKL043WverifiedTranscriptional activator that enhances pseudohyphal growth;regulates expression of FLO11, an adhesinrequired for pseudohyphal filament formation;similar to StuA, an A. nidulans developmentalregulator; potential Cdc28p substrate 0.044670.14664&radic&radic&radic S000005976LGE1YPL055CverifiedProtein of unknown function; null mutant forms abnormally largecells 0.04450.14607&radic&radic&radic S000002467MAK21YDR060WverifiedConstituent of 66S pre-ribosomal particles, required for large(60S) ribosomal subunit biogenesis; involved innuclear export of pre-ribosomes; required formaintenance of dsRNA virus; homolog of humanCAATT-binding protein 0.04440.14574&radic S000003142BUD13YGL174WverifiedSubunit of the RES complex, which is required for nuclearpre-mRNA retention and splicing; involved inbud-site selection; diploid mutants display aunipolar budding pattern instead of thewild-type bipolar pattern &radic0.044290.14548&radic&radic&radic&radic&radic S000001055ARD1YHR013CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.044310.14548&radic&radic S000005189CWC25YNL245CverifiedComponent of a complex containing Cef1p, involved in pre-mRNAsplicing; has similarity to S. pombe Cwf25p &radic0.044160.14509&radic&radic&radic&radic&radic S000002571SEC1YDR164CverifiedSm-like protein involved in docking and fusion of exocyticvesicles through binding to assembled SNAREcomplexes at the membrane; localization tosites of secretion (bud neck and bud tip) isdependent on SNARE function 0.04410.14471&radic&radic S000004210CCC1YLR220WverifiedPutative vacuolar Fe2+/Mn2+ transporter; suppresses respiratorydeficit of yfh1 mutants, which lack theortholog of mammalian frataxin, by preventingmitochondrial iron accumulation 0.044030.14458&radic S000005832YOR305WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; YOR305W is not an essential gene 0.043910.14418&radic&radic&radic S000002796RVS167YDR388WverifiedActin-associated protein, subunit of a complex(Rvs161p-Rvs167p) involved in regulation ofactin cytoskeleton, endocytosis, and viabilityfollowing starvation or osmotic stress; homologof mammalian amphiphysin 0.043890.14416&radic&radic&radic S000000818BIM1YER016WverifiedMicrotubule-binding protein that together with Kar9p makes upthe cortical microtubule capture site anddelays the exit from mitosis when the spindleis oriented abnormally 0.043750.1437 S000005674SPP2YOR148CverifiedEssential protein that promotes the first step of splicing andis required for the final stages of spliceosomematuration; interacts with Prp2p, which mayrelease Spp2p from the spliceosome followingthe first cleavage reaction &radic0.043730.14365&radic&radic&radic S000004571NUP188YML103CverifiedSubunit of the nuclear pore complex (NPC), involved in thestructural organization of the complex and ofthe nuclear envelope, also involved in nuclearenvelope permeability, interacts with Pom152pand Nic96p 0.043710.14354 S000003411OKP1YGR179CverifiedOuter kinetochore protein, required for accurate mitoticchromosome segregation; component of thekinetochore sub-complex COMA (Ctf19p, Okp1p,Mcm21p, Ame1p) that functions as a platform forkinetochore assembly 0.043490.14286&radic&radic&radic&radic S000005098YCK2YNL154CverifiedPalmitoylated, plasma membrane-bound casein kinase I isoform;shares redundant functions with Yck1p inmorphogenesis, proper septin assembly,endocytic trafficking; provides an essentialfunction overlapping with that of Yck1p 0.04340.14265&radic&radic&radic S000006373JIP5YPR169WuncharacterizedNucleolar protein of unknown function, exhibits a physicalinteraction with Bre1p 0.043360.1424&radic&radic&radic&radic S000001669MTR2YKL186CverifiedmRNA transport regulator, essential nuclear protein; Mex67p andMtr2p form a mRNA export complex which binds toRNA 0.043390.1424&radic&radic S000006325THI22YPR121WverifiedProtein with similarity to hydroxymethylpyrimidine phosphatekinases; member of a gene family with THI20 andTHI21; not required for thiamine biosynthesis 0.04310.14159&radic S000006376YPR172WUncharacterizedProtein of unknown function, transcriptionally activated by Yrm1p along with genes involved in multidrug resistance 0.043060.14139&radic&radic&radic&radic&radic S000001906UBP6YFR010WverifiedUbiquitin-specific protease situated in the base subcomplex ofthe 26S proteasome, releases free ubiquitinfrom branched polyubiquitin chains; deletioncauses hypersensitivity to cycloheximide andother toxic compounds 0.0430.14124&radic&radic&radic&radic&radic S000002776YPR1YDR368Wverified2-methylbutyraldehyde reductase, may be involved in isoleucinecatabolism 0.042940.141&radic&radic S000002701SSD1YDR293CverifiedProtein with a role in maintenance of cellular integrity,interacts with components of the TOR pathway;ssd1 mutant of a clinical S. cerevisiae straindisplays elevated virulence 0.042870.14074&radic&radic S000001305CBR1YIL043CverifiedMicrosomal cytochrome b reductase, not essential for viability;also detected in mitochondria; mutation inconserved NADH binding domain of the humanortholog results in type I methemoglobinemia 0.042750.14041&radic&radic&radic&radic&radic S000006090MEX67YPL169CverifiedPoly(A)RNA binding protein involved in nuclear mRNA export,component of the nuclear pore; ortholog ofhuman TAP 0.042780.14041&radic&radic S000003068SEH1YGL100WverifiedNuclear pore protein that is part of the evolutionarilyconserved Nup84p complex (Nup84p, Nup85p,Nup120p, Nup145p, and Seh1p); homologous toSec13p 0.042690.14014&radic&radic&radic S000002828HKR1YDR420WverifiedSerine/threonine rich cell surface protein that contains an EFhand motif; involved in the regulation of cellwall beta-1,3 glucan synthesis and bud siteselection; overexpression confers resistance toHansenula mrakii killer toxin, HM-1 0.042460.13949&radic&radic S000001318VHR1YIL056WuncharacterizedTranscriptional activator, required for the vitaminH-responsive element (VHRE) mediated inductionof VHT1 (Vitamin H transporter) and BIO5(biotin biosynthesis intermediate transporter)in response to low biotin concentrations 0.042290.13889&radic S000000203YBL107CUncharacterizedHypothetical protein 0.042150.1385&radic&radic S000002296ARF2YDL137WverifiedADP-ribosylation factor, GTPase of the Ras superfamily involvedin regulation of coated formation vesicles inintracellular trafficking within the Golgi;functionally interchangeable with Arf1p 0.042130.13846&radic&radic S000001108SSF1YHR066WverifiedConstituent of 66S pre-ribosomal particles, required forribosomal large subunit maturation;functionally redundant with Ssf2p; member ofthe Brix family 0.042120.13842&radic&radic&radic&radic&radic&radic S000002592ATC1YDR184CverifiedNuclear protein, possibly involved in regulation of cationstress responses and/or in the establishment ofbipolar budding pattern 0.041930.13775&radic&radic&radic&radic&radic&radic S000000939YER137CUncharacterizedHypothetical protein 0.041810.13744 S000001617OCT1YKL134CverifiedMitochondrial intermediate peptidase, cleaves N-terminalresidues of a subset of proteins upon import,after their cleavage by mitochondrialprocessing peptidase (Mas1p-Mas2p); maycontribute to mitochondrial iron homeostasis 0.041560.13655&radic&radic&radic S000003038RPB9YGL070CverifiedRNA polymerase II subunit B12.6; contacts DNA; mutations affecttranscription start site; involved in telomeremaintenance 0.041520.13655&radic&radic&radic S000001934IRC5YFR038WuncharacterizedPutative ATPase containing the DEAD/H helicase-related sequencemotif; null mutant displays increased levels ofspontaneous Rad52 foci 0.04110.13517&radic&radic S000004585NAB6YML117WuncharacterizedPutative RNA-binding protein, based on computational analysisof large-scale protein-protein interaction data 0.040990.13485 S000005242CLA4YNL298WverifiedCdc42p activated signal transducing kinase of the PAK(p21-activated kinase) family, involved inseptin ring assembly and cytokinesis; directlyphosphorylates septins Cdc3p and Cdc10p; otheryeast PAK family members are Ste20p and Skm1p 0.040930.13468 S000003241SEC9YGR009Cverifiedt-SNARE protein important for fusion of secretory vesicles withthe plasma membrane; similar to but notfunctionally redundant with Spo20p; SNAP-25homolog 0.04090.13461&radic&radic S000004920UBP15YMR304WverifiedUbiquitin-specific protease that may play a role in ubiquitinprecursor processing 0.040870.13456&radic&radic S000004762NUP53YMR153WverifiedSubunit of the nuclear pore complex (NPC), interacts withkaryopherin Kap121p or with Nup170p viaoverlapping regions of Nup53p, involved inactivation of the spindle checkpoint mediatedby the Mad1p-Mad2p complex 0.040850.13433&radic S000004022RAD5YLR032WverifiedSingle-stranded DNA-dependent ATPase, involved inpostreplication repair; contains RING fingerdomain 0.040810.13433&radic&radic&radic&radic&radic S000000667IMG2YCR071CverifiedMitochondrial ribosomal protein of the small subunit 0.040790.13428&radic&radic&radic&radic S000000175NUP170YBL079WverifiedAbundant subunit of the nuclear pore complex (NPC), requiredfor proper localization of specificnucleoporins within the NPC, involved innuclear envelope permeability and in chromosomesegregation, has similarity to Nup157p 0.040670.13381&radic&radic S000000682CSM1YCR086WverifiedNucleolar protein that forms a complex with Lrs4p which bindsMam1p at kinetochores during meiosis I tomediate accurate chromosome segregation, may beinvolved in premeiotic DNA replication;possible role in telomere maintenance 0.040640.13368&radic&radic&radic&radic S000004237IRC20YLR247CuncharacterizedPutative helicase; localized to mitochondria and the nucleus;YLR247C is not an essential gene; null mutantdisplays increased levels of spontaneous Rad52foci 0.04050.13321&radic&radic&radic S000005337ESF2YNR054CverifiedEssential nucleolar protein involved in pre-18S rRNAprocessing; component of the small subunit(SSU) processome; has sequence similarity tomABT1, a mouse transcription activator 0.04050.13321 S000006046KAP120YPL125WverifiedKaryopherin with a role in the assembly or export of 60Sribosomal subunits 0.040440.13297&radic S000000885GET2YER083CverifiedSubunit of the GET complex; required for meiotic nucleardivision and for the retrieval of HDEL proteinsfrom the Golgi to the ER in an ERD2 dependentfashion; may be involved in cell wall function 0.040390.13289&radic S000005148SPS18YNL204CverifiedProtein of unknown function, contains a putative zinc-bindingdomain; expressed during sporulation 0.040310.13262&radic&radic S000006139SAR1YPL218WverifiedGTPase, GTP-binding protein of the ARF family, component ofCOPII coat of vesicles; required for transportvesicle formation during ER to Golgi proteintransport 0.040170.13225 S000000416NGR1YBR212WverifiedRNA binding protein that negatively regulates growth rate;interacts with the 3' UTR of the mitochondrialporin (POR1) mRNA and enhances its degradation;overexpression impairs mitochondrial function;expressed in stationary phase 0.039910.13141&radic&radic S000005732NOC2YOR206WverifiedProtein that forms a nucleolar complex with Mak21p that bindsto 90S and 66S pre-ribosomes, as well as anuclear complex with Noc3p that binds to 66Spre-ribosomes; both complexes mediateintranuclear transport of ribosomal precursors 0.039890.13133&radic&radic&radic&radic S000000378YBR174CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective 0.039630.13049&radic&radic&radic&radic S000006284TEF1YPR080WverifiedTranslational elongation factor EF-1 alpha; also encoded byTEF2; functions in the binding reaction ofaminoacyl-tRNA (AA-tRNA) to ribosomes 0.039520.13006 S000000912KAP123YER110CverifiedKaryopherin beta, mediates nuclear import of ribosomal proteinsprior to assembly into ribosomes and import ofhistones H3 and H4; localizes to the nuclearpore, nucleus, and cytoplasm; exhibits geneticinteractions with RAI1 0.039410.12966&radic S000002600NUP42YDR192CverifiedSubunit of the nuclear pore complex (NPC) that localizesexclusively to the cytoplasmic side; involvedin RNA export, most likely at a terminal step;interacts with Gle1p 0.039330.1294&radic S000001596RAD27YKL113Cverified5' to 3' exonuclease, 5' flap endonuclease, required forOkazaki fragment processing and maturation aswell as for long-patch base-excision repair;member of the S. pombe RAD2/FEN1 family 0.039160.1288&radic&radic S000002198NAT1YDL040CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.038980.12821&radic&radic&radic S000001622CTK1YKL139WverifiedCatalytic (alpha) subunit of C-terminal domain kinase I(CTDK-I), which phosphorylates the C-terminalrepeated domain of the RNA polymerase II largesubunit (Rpo21p) to affect both transcriptionand pre-mRNA 3' end processing 0.038920.12795&radic&radic S000003851JSN1YJR091CverifiedMember of the Puf family of RNA-binding proteins, interactswith mRNAs encoding membrane-associatedproteins; overexpression suppresses a tub2-150mutation and causes increased sensitivity tobenomyl in wild-type cells 0.038780.12756 S000006316MRD1YPR112CverifiedEssential conserved protein that associates with 35S precursorrRNA and is required for its initial processingat the A(0)-A(2) cleavage sites, shows partialnucleolar localization, contains five consensusRNA-binding domains 0.038730.12742&radic&radic S000004099AHP1YLR109WverifiedThiol-specific peroxiredoxin, reduces hydroperoxides to protectagainst oxidative damage; function in vivorequires covalent conjugation to Urm1p 0.038690.12724&radic&radic&radic S000000851TPA1YER049WuncharacterizedProtein of unknown function; interacts with Sup45p (eRF1),Sup35p (eRF3) and Pab1p; has a role intranslation termination efficiency, mRNApoly(A) tail length and mRNA stability 0.038470.12653&radic&radic&radic&radic&radic S000000838ARB1YER036CverifiedATPase of the ATP-binding cassette (ABC) family involved in 40Sand 60S ribosome biogenesis, has similarity toGcn20p; shuttles from nucleus to cytoplasm,physically interacts with Tif6p, Lsg1p 0.038440.1264 S000004198SEC13YLR208WverifiedComponent of both the Nup84 nuclear pore sub-complex and of theCOPII complex (Sar1p, Sec13p, Sec16p, Sec23p,Sec24p, Sec31p, Sfb2p, and Sfb3p) which isimportant for the formation of ER to Golgitransport vesicles 0.03830.12591&radic&radic S000003427SKI6YGR195Wverified3'-to-5' phosphorolytic exoribonuclease that is a subunit ofthe exosome; required for 3' processing of the5.8S rRNA; involved in 3' to 5' mRNAdegradation and translation inhibition ofnon-poly(A) mRNAs 0.038240.12577&radic&radic S000004665RNA14YMR061WverifiedCleavage and polyadenylation factor I (CF I) component involvedin cleavage and polyadenylation of mRNA 3'ends; bridges interaction between Rna15p andHrp1p in the CF I complex 0.038190.12563&radic&radic&radic S000004889DSK2YMR276WverifiedNuclear-enriched ubiquitin-like polyubiquitin-binding protein,required for spindle pole body (SPB)duplication and for transit through the G2/Mphase of the cell cycle, involved inproteolysis, interacts with the proteasome 0.038180.12543&radic&radic S000002865TOM1YDR457WverifiedE3 ubiquitin ligase of the hect-domain class; has a role inmRNA export from the nucleus and may regulatetranscriptional coactivators 0.038050.12509&radic&radic&radic S000002636PCF11YDR228CverifiedmRNA 3' end processing factor, essential component of cleavageand polyadenylation factor IA (CF IA), involvedin pre-mRNA 3' end processing and intranscription termination; binds C-terminaldomain of largest subunit of RNA pol II(Rpo21p) 0.038050.12509&radic&radic&radic&radic&radic S000000070ADE1YAR015WverifiedN-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR)synthetase, required for 'de novo' purinenucleotide biosynthesis; red pigmentaccumulates in mutant cells deprived of adenine 0.038020.12501&radic&radic&radic&radic&radic&radic&radic S000001072SLT2YHR030CverifiedSerine/threonine MAP kinase involved in regulating themaintenance of cell wall integrity andprogression through the cell cycle; regulatedby the PKC1-mediated signaling pathway 0.037940.12471&radic&radic S000001693UBA1YKL210WverifiedUbiquitin activating enzyme, involved in ubiquitin-mediatedprotein degradation and essential for viability 0.037930.12471&radic&radic&radic S000000339CKS1YBR135WverifiedSubunit of the Cdc28 protein kinase, required for mitoticproteolysis, may also be involved in theproteolysis of the G1 cyclins 0.037910.12464&radic S000005873REV1YOR346WverifiedDeoxycytidyl transferase, forms a complex with the subunits ofDNA polymerase zeta, Rev3p and Rev7p; involvedin repair of abasic sites in damaged DNA 0.037830.12435&radic&radic&radic&radic&radic S000005190VPS75YNL246WverifiedProtein of unknown function involved in vacuolar proteinsorting; detected in the nucleus 0.037790.12416&radic&radic&radic&radic&radic S000003466YHB1YGR234WverifiedNitric oxide oxidoreductase, flavohemoglobin involved in nitricoxide detoxification; plays a role in theoxidative and nitrosative stress responses 0.037710.12406 S000002587YDR179W-AUncharacterizedHypothetical protein 0.037590.12376&radic&radic&radic&radic&radic S000006105MRN1YPL184CuncharacterizedPutative RNA binding protein 0.037550.12361&radic&radic S000005194RAD50YNL250WverifiedSubunit of MRX complex, with Mre11p and Xrs2p, involved inprocessing double-strand DNA breaks invegetative cells, initiation of meiotic DSBs,telomere maintenance, and nonhomologous endjoining 0.037520.12351&radic S000004252YPT6YLR262CverifiedGTPase, Ras-like GTP binding protein involved in the secretorypathway, required for fusion ofendosome-derived vesicles with the late Golgi,maturation of the vacuolar carboxypeptidase Y;has similarity to the human GTPase, Rab6 0.037520.12351&radic&radic&radic S000005642RPO31YOR116CverifiedRNA polymerase III subunit C160, part of core enzyme; similarto bacterial beta-prime subunit 0.03750.12348&radic&radic&radic S000000104HIR1YBL008WverifiedNon-essential transcriptional corepressor involved in the cellcycle-regulated transcription of histone H2A,H2B, H3 and H4 genes; contributes to nucleosomeformation, heterochromatic gene silencing, andformation of functional kinetochores 0.037490.12343&radic&radic S000004925PSE1YMR308CverifiedKaryopherin/importin that interacts with the nuclear porecomplex; acts as the nuclear import receptorfor specific proteins, including Pdr1p, Yap1p,Ste12p, and Aft1p 0.037470.12331&radic&radic S000003704SET2YJL168CverifiedHistone methyltransferase with a role in transcriptionalelongation, methylates a lysine residue ofhistone H3; associates with the C-terminaldomain of Rpo21p; histone methylation activityis regulated by phosphorylation status ofRpo21p 0.037280.12262&radic&radic&radic&radic S000002251PMT5YDL093WverifiedProtein O-mannosyltransferase, transfers mannose residues fromdolichyl phosphate-D-mannose to proteinserine/threonine residues; acts in a complexwith Pmt3p, can instead interact with Pmt2p insome conditions; target for new antifungals 0.036960.12168&radic&radic&radic&radic S000000439YBR235WUncharacterizedPutative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene 0.036950.12165&radic&radic&radic S000003335NOP7YGR103WverifiedNucleolar protein involved in rRNA processing and 60S ribosomalsubunit biogenesis; constituent of severaldifferent pre-ribosomal particles; required forexit from G0 and the initiation ofcell proliferation 0.036830.12135&radic&radic&radic&radic&radic&radic S000004279MEC3YLR288CverifiedDNA damage and meiotic pachytene checkpoint protein; subunit ofa heterotrimeric complex (Rad17p-Mec3p-Ddc1p)that forms a sliding clamp, loaded onto partialduplex DNA by a clamp loader complex; homologof human and S. pombe Hus1 0.036710.12093&radic&radic&radic&radic S000004017AAT2YLR027CverifiedCytosolic aspartate aminotransferase, involved in nitrogenmetabolism; localizes to peroxisomes inoleate-grown cells 0.036570.12058&radic S000003200YGL231CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum 0.036480.12028&radic&radic&radic&radic&radic S000004486RPS17AYML024WverifiedRibosomal protein 51 (rp51) of the small (40s) subunit; nearlyidentical to Rps17Bp and has similarity to ratS17 ribosomal protein 0.036420.1201&radic&radic S000000007SPO7YAL009WverifiedIntegral nuclear/ER membrane protein of unknown function,required for normal nuclear envelope morphologyand sporulation 0.036410.12004&radic&radic S000000907NUP157YER105CverifiedAbundant subunit of the nuclear pore complex (NPC), present onboth sides of the NPC, has similarity toNup170p 0.036320.11974 S000003740RCY1YJL204CverifiedF-box protein involved in recycling plasma membrane proteinsinternalized by endocytosis; localized to sitesof polarized growth 0.03620.11937&radic&radic&radic&radic&radic&radic S000000566MRC1YCL061CverifiedS-phase checkpoint protein found at replication forks, requiredfor DNA replication; also required for Rad53pactivation during DNA replication stress, whereit forms a replication-pausing complex withTof1p and is phosphorylated by Mec1p; proteininvolved in replication checkpoint 0.036130.11921&radic&radic&radic S000006161HSP82YPL240CverifiedCytoplasmic chaperone (Hsp90 family) required for pheromonesignaling and negative regulation of Hsf1p;docks with the mitochondrial import receptorTom70p for preprotein delivery; interacts withco-chaperones Cns1p, Cpr6p, Cpr7p, and Sti1p 0.03610.11907&radic&radic&radic&radic S000004917YME2YMR302CverifiedIntegral inner mitochondrial membrane protein with similarityto exonucleases; mutants exhibit an increasedrate of mitochondrial DNA escape 0.036080.11907&radic S000004008POM34YLR018CverifiedIntegral membrane protein of the nuclear pore; has an importantrole in maintaining the architecture of thepore complex 0.036070.11898&radic S000004949HRB1YNL004WverifiedPoly(A+) RNA-binding protein, involved in the export of mRNAsfrom the nucleus to the cytoplasm; similar toGbp2p and Npl3p 0.036010.1188&radic S000004004PPR1YLR014CverifiedZinc finger transcription factor containing a Zn(2)-Cys(6)binuclear cluster domain, positively regulatestranscription of genes involved in uracilbiosynthesis; activity may be modulated byinteraction with Tup1p 0.036010.1188&radic&radic&radic&radic S000004018ADE16YLR028CverifiedEnzyme of 'de novo' purine biosynthesis containing both5-aminoimidazole-4-carboxamide ribonucleotidetransformylase and inosine monophosphatecyclohydrolase activities, isozyme of Ade17p;ade16 ade17 mutants require adenine andhistidine 0.035690.11776 S000000827GCD11YER025WverifiedGamma subunit of the translation initiation factor eIF2,involved in the identification of the startcodon; binds GTP when forming the ternarycomplex with GTP and tRNAi-Met 0.035660.11763&radic&radic&radic&radic&radic S000001268YIA6YIL006WverifiedMitochondrial NAD+ transporter, involved in the transport ofNAD+ into the mitochondria (see also YEA6);member of the mitochondrial carrier subfamily;disputed role as a pyruvate transporter; hasputative mouse and human orthologs 0.035620.11746&radic S000003414YGR182CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W 0.035490.11702&radic&radic S000004806MRPL24YMR193WverifiedMitochondrial ribosomal protein of the large subunit 0.035480.11698&radic&radic&radic S000006395QCR2YPR191WverifiedSubunit 2 of the ubiquinol cytochrome-c reductase complex,which is a component of the mitochondrial innermembrane electron transport chain;transcription is regulated by Hap1p,Hap2p/Hap3p, and heme 0.035440.11689 S000002493SSS1YDR086CverifiedSubunit of the Sec61p translocation complex(Sec61p-Sss1p-Sbh1p) that forms a channel forpassage of secretory proteins through theendoplasmic reticulum membrane, and of theSsh1p complex (Ssh1p-Sbh2p-Sss1p); interactswith Ost4p and Wbp1p 0.035410.11678&radic S000006043TFB2YPL122CverifiedSubunit of TFIIH and nucleotide excision repair factor 3complexes, involved in transcriptioninitiation, required for nucleotide excisionrepair, similar to 52 kDa subunit of humanTFIIH 0.035380.11668&radic&radic&radic&radic&radic&radic S000002637IVY1YDR229WverifiedPhospholipid-binding protein that interacts with both Ypt7p andVps33p, may partially counteract the action ofVps33p and vice versa, localizes to the rim ofthe vacuole as cells approach stationary phase 0.035350.11639&radic&radic&radic&radic S000002243NDE2YDL085WverifiedMitochondrial external NADH dehydrogenase, catalyzes theoxidation of cytosolic NADH; Nde1p and Nde2pare involved in providing the cytosolic NADH tothe mitochondrial respiratory chain 0.03530.11639&radic S000002588SCC2YDR180WverifiedSubunit of cohesin loading factor (Scc2p-Scc4p), a complexrequired for the loading of cohesin complexesonto chromosomes; involved in establishingsister chromatid cohesion during DSB repair viahistone H2AX 0.035310.11639&radic&radic&radic&radic S000003760YJL225CUncharacterizedPutative protein of unknown function; similarity to DNA helicases that are also encoded within subtelomeric Y' elements and induced in telomerase deficient survivors 0.035290.11627 S000005843COT1YOR316CverifiedVacuolar transporter that mediates zinc transport into thevacuole; overexpression confers resistance tocobalt and rhodium 0.035260.1162 S000000004SSA1YAL005CverifiedATPase involved in protein folding and nuclear localizationsignal (NLS)-directed nuclear transport; memberof heat shock protein 70 (HSP70) family; formsa chaperone complex with Ydj1p; localized tothe nucleus, cytoplasm, and cell wall 0.035220.11602&radic&radic&radic&radic&radic S000003003MIG1YGL035CverifiedTranscription factor involved in glucose repression; C2H2 zincfinger protein similar to mammalian Egr andWilms tumor proteins 0.035190.11597&radic S000001160ORC6YHR118CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing; may be phosphorylated by Cdc28p 0.035120.11573&radic&radic&radic&radic&radic S000002232BRE1YDL074CverifiedE3 ubiquitin ligase for Rad6p, required for the ubiquitinationof histone H2B, recruitment of Rad6p topromoter chromatin and subsequent methylationof histone H3 (on L4 and L79), contains RINGfinger domain 0.035090.11547&radic&radic&radic&radic S000002684PMP3YDR276CverifiedSmall plasma membrane protein related to a family of plantpolypeptides that are overexpressed under highsalt concentration or low temperature, notessential for viability, deletion causeshyperpolarization of the plasma membranepotential 0.03510.11547&radic&radic S000001803MLP1YKR095WverifiedMyosin-like protein associated with the nuclear envelope,connects the nuclear pore complex with thenuclear interior; involved with Tel1p intelomere length control; involved with Pml1pand Pml39p in nuclear retention of unsplicedmRNAs 0.035010.11537 S000004550TUB1YML085CverifiedAlpha-tubulin; associates with beta-tubulin (Tub2p) to formtubulin dimer, which polymerizes to formmicrotubules 0.034960.1152&radic S000001405SSL2YIL143CverifiedComponent of the holoenzyme form of RNA polymerasetranscription factor TFIIH, has DNA-dependentATPase/helicase activity and is required, withRad3p, for unwinding promoter DNA; involved inDNA repair; homolog of human ERCC3 0.034890.11504&radic S000004527MFT1YML062CverifiedSubunit of the THO complex, which is a nuclear complexcomprised of Hpr1p, Mft1p, Rlr1p, and Thp2p,that is involved in transcription elongationand mitotic recombination; involved in telomeremaintenance 0.034820.11476&radic&radic&radic S000003782REC107YJR021CverifiedProtein involved in early stages of meiotic recombination;involved in altering chromatin structure at DNAdouble-stranded break sites and in coordinationbetween the initiation of recombination and thefirst division of meiosis 0.034820.11476&radic&radic&radic&radic S000003700TPK1YJL164CverifiedSubunit of cytoplasmic cAMP-dependent protein kinase, whichcontains redundant catalytic subunits Tpk1p,Tpk2p, and Tpk3p and regulatory subunit Bcy1p;promotes vegetative growth in response tonutrients; inhibits filamentous growth 0.034830.11476&radic&radic&radic&radic&radic S000001340THS1YIL078WverifiedThreonyl-tRNA synthetase, essential cytoplasmic protein 0.034820.1147&radic&radic&radic S000001061DED81YHR019CverifiedCytosolic asparaginyl-tRNA synthetase, required for proteinsynthesis, catalyzes the specific attachment ofasparagine to its cognate tRNA 0.034790.11461&radic S000005812FMP31YOR286WuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.034780.11461&radic&radic S000005149YNL205CDubiousHypothetical protein 0.034670.11421&radic&radic&radic S000001868STE2YFL026WverifiedReceptor for alpha-factor pheromone; seven transmembrane-domainGPCR that interacts with both pheromone and aheterotrimeric G protein to initiate thesignaling response that leads to mating betweenhaploid a and alpha cells 0.034650.11415&radic&radic&radic S000003592ZAP1YJL056CverifiedZinc-regulated transcription factor, binds to zinc-responsivepromoter elements to induce transcription ofcertain genes in the presence of zinc;regulates its own transcription; contains sevenzinc-finger domains 0.034610.11399&radic S000000992YRF1-2YER190WverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p 0.034590.11393&radic&radic&radic S000004736POM152YMR129WverifiedNuclear pore membrane glycoprotein; may be involved induplication of nuclear pores and nuclear porecomplexes during S-phase; 0.034460.11343 S000005682NFI1YOR156CverifiedSUMO ligase, catalyzes the covalent attachment of SUMO (Smt3p)to proteins; involved in maintenance of propertelomere length 0.034420.11321&radic&radic&radic&radic&radic&radic S000004312MMS22YLR320WverifiedProtein involved in resistance to ionizing radiation; acts withMms1p in a repair pathway that may be involvedin resolving replication intermediates orpreventing the damage caused by blockedreplication forks 0.034270.11274&radic S000004961PUB1YNL016WverifiedPoly(A)+ RNA-binding protein, abundant mRNP-component proteinthat binds mRNA and is required for stabilityof a number of mRNAs; not reported to associatewith polyribosomes 0.034230.11263 S000002872SPP41YDR464WverifiedProtein involved in negative regulation of expression ofspliceosome components PRP4 and PRP3 0.034250.11263&radic&radic S000005335POP2YNR052CverifiedRNase of the DEDD superfamily, subunit of the Ccr4-Not complexthat mediates 3' to 5' mRNA deadenylation 0.034230.11263 S000000064SWD1YAR003WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres; WD40beta propeller superfamily member withsimilarity to mammalian Rbbp7 0.034140.11234&radic&radic S000006133PUS1YPL212CverifiedtRNA:pseudouridine synthase, introduces pseudouridines atpositions 26-28, 34-36, 65, and 67 of tRNA;nuclear protein that appears to be involved intRNA export; also acts on U2 snRNA 0.034140.11234&radic&radic&radic&radic S000001149CDC12YHR107CverifiedComponent of the septin ring of the mother-bud neck that isrequired for cytokinesis; septins recruitproteins to the neck and can act as a barrierto diffusion at the membrane, and they comprisethe 10nm filaments seen with EM 0.03410.11222 S000003941DPS1YLL018CverifiedCytoplasmic aspartyl-tRNA synthetase, homodimeric enzyme thatcatalyzes the specific aspartylation oftRNA(Asp); class II aminoacyl tRNA synthetase;binding to its own mRNA may conferautoregulation 0.034080.11213&radic&radic&radic S000001566YKL083WDubiousDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14 0.033990.11187&radic&radic&radic&radic&radic S000001210THP2YHR167WverifiedSubunit of the THO complex, which connects transcriptionelongation and mitotic recombination, and ofthe TREX complex, which is recruited toactivated genes and couples transcription tomRNA export; involved in telomere maintenance 0.033960.11175&radic S000005861MRS2YOR334WverifiedMitochondrial inner membrane Mg(2+) channel, required formaintenance of intramitochondrial Mg(2+)concentrations at the correct level to supportsplicing of group II introns &radic0.033950.11173&radic S000003665TRK1YJL129CverifiedComponent of the Trk1p-Trk2p potassium transport system; 180kDa high affinity potassium transporter;phosphorylated in vivo and interacts physicallywith the phosphatase Ppz1p, suggesting Trk1pacitivy is regulated by phosphorylation 0.033920.11162&radic S000004837MRE11YMR224CverifiedSubunit of a complex with Rad50p and Xrs2p (RMX complex) thatfunctions in repair of DNA double-strand breaksand in telomere stability, exhibits nucleaseactivity that appears to be required for RMXfunction; widely conserved 0.033830.1113&radic&radic&radic&radic&radic S000001094CIC1YHR052WverifiedEssential protein that interacts with proteasome components andhas a potential role in proteasome substratespecificity; also copurifies with 66Spre-ribosomal particles 0.033810.11121&radic S000005208PDR17YNL264CverifiedPhosphatidylinositol transfer protein (PITP), downregulatesPlb1p-mediated turnover of phosphatidylcholine,found in the cytosol and microsomes, homologousto Pdr16p, deletion affects phospholipidcomposition 0.033760.111&radic&radic&radic&radic&radic S000000615HSP30YCR021CverifiedHydrophobic plasma membrane localized, stress-responsiveprotein that negatively regulates theH(+)-ATPase Pma1p; induced by heat shock,ethanol treatment, weak organic acid, glucoselimitation, and entry into stationary phase 0.03370.11089&radic S000002471RPS13YDR064WverifiedProtein component of the small (40S) ribosomal subunit; hassimilarity to E. coli S15 and rat S13 ribosomalproteins 0.033660.11079&radic&radic&radic&radic&radic&radic S000000229YBR025CUncharacterizedHypothetical protein 0.033580.11046&radic&radic&radic&radic S000005215BNI1YNL271CverifiedFormin, nucleates the formation of linear actin filaments,involved in cell processes such as budding andmitotic spindle orientation which require theformation of polarized actin cables,functionally redundant with BNR1 0.033550.11039&radic S000002647YDR239CUncharacterizedHypothetical protein 0.033520.1102&radic&radic S000001760MRS4YKR052CverifiedMitochondrial iron transporter of the mitochondrial carrierfamily (MCF), very similar to and functionallyredundant with Mrs3p; functions under low-ironconditions; may transport other cations inaddition to iron &radic0.033480.11014&radic S000001758TRK2YKR050WverifiedComponent of the Trk1p-Trk2p potassium transport system 0.033460.11007 S000004140STM1YLR150WverifiedProtein that binds G4 quadruplex and purine motif triplexnucleic acid; acts with Cdc13p to maintaintelomere structure; interacts with ribosomesand subtelomeric Y' DNA; multicopy suppressorof tom1 and pop2 mutations 0.033420.1099&radic S000004898NGL2YMR285CverifiedProtein involved in 5.8S rRNA processing; Ccr4p-like RNaserequired for correct 3'-end formation of 5.8SrRNA at site E; similar to Ngl1p and Ngl3p 0.033380.10979&radic&radic S000002764SPC110YDR356WverifiedInner plaque spindle pole body (SPB) component, ortholog ofhuman kendrin; involved in connecting nuclearmicrotubules to SPB; interacts withTub4p-complex and calmodulin; phosphorylated byMps1p in cell cycle-dependent manner 0.033180.10908&radic&radic&radic S000004999VAC7YNL054WverifiedIntegral vacuolar membrane protein involved in vacuoleinheritance and morphology; may function toregulate Fab1p kinase activity 0.033160.10908&radic&radic&radic S000005564HIR2YOR038CverifiedNon-essential transcriptional corepressor involved in the cellcycle-regulated transcription of histone H2A,H2B, H3, and H4 genes; recruits Swi-Snfcomplexes to histone gene promoters; promotesheterochromatic gene silencing with Asf1p 0.033120.10891&radic&radic S000001146GRE3YHR104WverifiedAldose reductase involved in methylglyoxal, d-xylose andarabinose metabolism; stress induced (osmotic,ionic, oxidative, heat shock, starvation andheavy metals); regulated by the HOG pathway 0.033020.10853&radic&radic&radic&radic&radic S000006047NAN1YPL126WverifiedU3 snoRNP protein, component of the small (ribosomal) subunit(SSU) processosome containing U3 snoRNA;required for the biogenesis of18S rRNA 0.032950.10841&radic&radic S000001325YRB2YIL063CverifiedProtein of unknown function involved in nuclear processes ofthe Ran-GTPase cycle; involved in nuclearprotein export; contains Ran Binding Domain andFxFG repeats; interacts with Srm1p, GTP-Gsp1p,Rna1p and Crm1p; is not essential 0.032940.1084&radic&radic S000005155YNL211CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene 0.032930.10838&radic&radic&radic S000000897RAD51YER095WverifiedStrand exchange protein, forms a helical filament with DNA thatsearches for homology; involved in therecombinational repair of double-strand breaksin DNA during vegetative growth and meiosis;homolog of Dmc1p and bacterial RecA protein 0.032910.10831&radic S000003344SHY1YGR112WverifiedMitochondrial inner membrane protein required for normalrespiration, possible chaperone involved inassembly of cytochrome c oxidase; similar toSURF1 from mammals, chickens, and D.melanogaster 0.032880.10821&radic&radic&radic S000004478PPZ1YML016CverifiedSerine/threonine protein phosphatase Z, isoform of Ppz2p;involved in regulation of potassium transport,which affects osmotic stability, cell cycleprogression, and halotolerance 0.032850.10808 S000005622RPS7AYOR096WverifiedProtein component of the small (40S) ribosomal subunit, nearlyidentical to Rps7Bp; interacts with Kti11p;deletion causes hypersensitivity to zymocin;has similarity to rat S7 and Xenopus S8ribosomal proteins 0.03280.10784 S000002447ENA1YDR040CverifiedP-type ATPase sodium pump, involved in Na+ and Li+ efflux toallow salt tolerance 0.032710.10768&radic&radic S000005753YOR227WUncharacterizedHypothetical protein 0.032670.10754&radic S000002388SSB1YDL229WverifiedCytoplasmic ATPase that is a ribosome-associated molecularchaperone, functions with J-protein partnerZuo1p; may be involved in folding of newly-madepolypeptide chains; member of the HSP70 family;interacts with phosphatase subunit Reg1p 0.032660.10743 S000001505CDC16YKL022CverifiedSubunit of the anaphase-promoting complex/cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition; required forsporulation 0.032640.10743&radic&radic&radic&radic&radic&radic S000001204YAP1801YHR161CverifiedProtein involved in clathrin cage assembly; binds Pan1p andclathrin; homologous to Yap1802p, member of theAP180 protein family 0.032590.10729&radic S000000306EXO84YBR102CverifiedEssential protein with dual roles in spliceosome assembly andexocytosis; the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p) mediates polarized targeting ofsecretory vesicles to active sites ofexocytosis &radic0.032540.10711&radic&radic S000003693FAR1YJL157CverifiedCyclin-dependent kinase inhibitor that mediates cell cyclearrest in response to pheromone; also forms acomplex with Cdc24p, Ste4p, and Ste18p that mayspecify the direction of polarized growthduring mating; potential Cdc28p substrate 0.03250.10691&radic&radic&radic&radic&radic&radic S000001308MET30YIL046WverifiedF-box protein containing five copies of the WD40 motif,controls cell cycle function, sulfurmetabolism, and methionine biosynthesis as partof the ubiquitin ligase complex; interacts withand regulates Met4p, localizes within thenucleus 0.032460.1068&radic&radic&radic&radic&radic S000006356URN1YPR152CuncharacterizedPre-mRNA splicing factor associated with the U2-U5-U6 snRNPs,the RES complex, and the Prp19-associatedcomplex (NTC); null mutation displays syntheticgenetic interactions with mutations affectingU2 snRNA and pre-mRNA splicing factors 0.032350.10645&radic&radic&radic S000005996GCR1YPL075WverifiedTranscriptional activator of genes involved in glycolysis;DNA-binding protein that interacts andfunctions with the transcriptional activatorGcr2p 0.032330.10631&radic&radic&radic&radic&radic S000004334FKS1YLR342WverifiedCatalytic subunit of 1,3-beta-D-glucan synthase, functionallyredundant with alternate catalytic subunitGsc2p; binds to regulatory subunit Rho1p;involved in cell wall synthesis andmaintenance; localizes to sites of cell wallremodeling 0.032250.10616&radic S000004424IMD3YLR432WverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 0.032230.1061 S000003196VID30YGL227WverifiedProtein involved in proteasome-dependent catabolite degradationof fructose-1,6-bisphosphatase (FBPase); shiftsthe balance of nitrogen metabolism toward theproduction of glutamate; localized to thenucleus and the cytoplasm 0.03220.10599&radic&radic&radic S000004493NDC1YML031WverifiedNuclear envelope protein with multiple putative transmembranedomains, required for nuclear pore complexassembly and spindle pole body duplication;required for meiosis II 0.032190.10599 S000002570CWC15YDR163WverifiedNon-essential protein involved in pre-mRNA splicing, componentof a complex containing Cef1p; has similarityto S. pombe Cwf15p &radic0.032130.10579&radic&radic S000005929CHL1YPL008WverifiedConserved nuclear protein required to establishsister-chromatid pairing during S-phase,probable DNA helicase with similarity to humanBACH1, which associates with tumor suppressorBRCA1; associates with acetyltransferase Ctf7p 0.0320.10541&radic&radic&radic S000000019CCR4YAL021CverifiedComponent of the CCR4-NOT transcriptional complex, which isinvolved in regulation of gene expression;component of the major cytoplasmic deadenylase,which is involved in mRNA poly(A) tailshortening 0.031990.10535&radic S000001042YHL050CUncharacterizedPutative protein of unknown function, potential Cdc28p substrate 0.031980.10532 S000004614CLU1YMR012WverifiedeIF3 component of unknown function; deletion causes defects inmitochondrial organization but not in growth ortranslation initiation, can rescue cytokinesisand mitochondrial organization defects of theDictyostelium cluA- mutant 0.031960.10529&radic S000001780SIS2YKR072CverifiedNegative regulatory subunit of the protein phosphatase 1 Ppz1p;involved in ion homeostasis and cell cycleprogression 0.031910.10507&radic&radic&radic&radic S000000398SOY1YBR194WuncharacterizedProtein proposed to be associated with the nuclear pore complex 0.031850.10495&radic&radic S000005036YNL092WUncharacterizedPutative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene 0.031840.10493 S000003368LSB1YGR136WverifiedProtein containing an N-terminal SH3 domain; binds Las17p,which is a homolog of human Wiskott-AldrichSyndrome protein involved in actin patchassembly and actin polymerization 0.031820.10485&radic&radic&radic S000005192RPA49YNL248CverifiedRNA polymerase I subunit A49 0.031760.10464&radic&radic S000001564TEF4YKL081WverifiedTranslation elongation factor EF-1 gamma 0.031760.10464&radic S000003802URB2YJR041CverifiedNucleolar protein required for normal metabolism of the rRNAprimary transcript, proposed to be involved inribosome biogenesis 0.031720.10456&radic S000004171VTA1YLR181CverifiedMultivesicular body (MVB) protein involved in endosomal proteinsorting; binds to Vps20p and Vps4p; mayregulate Vps4p function; bindsVps60p and mayact at a late step in MVB formation; mutantsshow class E vacuolar-protein sorting defects 0.031710.10455&radic&radic S000004842RRP5YMR229CverifiedProtein required for the synthesis of both 18S and 5.8S rRNA;C-terminal region is crucial for the formationof 18S rRNA and N-terminal region is requiredfor the 5.8S rRNA; component of small ribosomalsubunit (SSU) processosome 0.031620.10414&radic S000003628HPR5YJL092WverifiedDNA helicase and DNA-dependent ATPase involved in DNA repair,required for proper timing of commitment tomeiotic recombination and the transition fromMeiosis I to Meiosis II; potential Cdc28psubstrate 0.03160.10397&radic S000002780VPS74YDR372CverifiedNon-essential protein of unknown function involved in vacuolarprotein sorting; belongs to a family ofcytosolic Golgi-associated proteins suggestingthat it may play a role in secretion; alsodetected in the nucleus 0.031560.10397&radic&radic&radic&radic&radic S000002187ARP2YDL029WverifiedEssential component of the Arp2/3 complex, which is a highlyconserved actin nucleation center required forthe motility and integrity of actin patches;involved in endocytosis and membrane growth andpolarity 0.031440.10363&radic&radic S000001005OTU2YHL013CverifiedProtein of unknown function that may interact with ribosomes,based on co-purification experiments; member ofthe ovarian tumor-like (OTU) superfamily ofpredicted cysteine proteases; shows cytoplasmiclocalization 0.031450.10363&radic&radic&radic&radic&radic S000005617TMA46YOR091WverifiedProtein of unknown function that associates with ribosomes;interacts with GTPase Rbg1p 0.031420.10353&radic S000005343FRE4YNR060WverifiedFerric reductase, reduces a specific subset ofsiderophore-bound iron prior to uptake bytransporters; expression induced by low ironlevels 0.031380.10339&radic&radic&radic S000005176CSL4YNL232WverifiedSubunit of the exosome, which is an essential complex presentin both nucleus and cytoplasm that mediates RNAprocessing and degradation 0.031270.10306&radic&radic&radic&radic&radic S000001828YFL066CUncharacterizedHelicase-like protein encoded within the telomeric Y' element 0.031130.10259 S000000065RFA1YAR007CverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 0.031160.10259&radic&radic&radic&radic S000005283YRF1-6YNL339CverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p 0.03110.10252&radic S000004069SIC1YLR079WverifiedInhibitor of Cdc28-Clb kinase complexes that controls G1/Sphase transition, preventing premature S phaseand ensuring genomic integrity; phosphorylationtargets Sic1p for SCF(CDC4)-dependent turnover;functional homolog of mammalian Kip1 0.031060.10237&radic&radic S000004663SEN15YMR059WverifiedSubunit of the tRNA splicing endonuclease, which is composed ofSen2p, Sen15p, Sen34p, and Sen54p &radic0.031040.10214&radic S000002988GET1YGL020CverifiedSubunit of the GET complex; required for the retrieval of HDELproteins from the Golgi to the ER in an ERD2dependent fashion and for normal mitochondrialmorphology and inheritance 0.031020.10214 S000005364SIN3YOL004WverifiedComponent of the Sin3p-Rpd3p histone deacetylase complex,involved in transcriptional repression andactivation of diverse processes, includingmating-type switching and meiosis; involved inthe maintenance of chromosomal integrity 0.030980.10205&radic S000001655EBP2YKL172WverifiedEssential protein required for the maturation of 25S rRNA and60S ribosomal subunit assembly, localizes tothe nucleolus; constituent of 66S pre-ribosomalparticles 0.030990.10205&radic&radic&radic&radic&radic&radic S000001070DAP2YHR028CverifiedDipeptidyl aminopeptidase, synthesized as a glycosylatedprecursor; localizes to the vacuolar membrane;similar to Ste13p 0.030960.102&radic&radic&radic&radic&radic&radic S000002349UFD2YDL190CverifiedUbiquitin chain assembly factor (E4) that cooperates with aubiquitin-activating enzyme (E1), aubiquitin-conjugating enzyme (E2), and aubiquitin protein ligase (E3) to conjugateubiquitin to substrates; also functions as an 0.030940.1019&radic&radic S000001162MSH1YHR120WverifiedDNA-binding protein of the mitochondria involved in repair ofmitochondrial DNA, has ATPase activity andbinds to DNA mismatches; has homology to E.coli MutS; transcription is induced duringmeiosis 0.030850.10163&radic&radic&radic S000005197TEX1YNL253WverifiedProtein involved in mRNA export, component of the transcriptionexport (TREX) complex 0.03080.10145&radic S000002299RPO21YDL140CverifiedRNA polymerase II largest subunit B220, part of central core;phosphorylation of C-terminal heptapeptiderepeat domain regulates association withtranscription and splicing factors; similar tobacterial beta-prime 0.030790.10145&radic S000006236SRO7YPR032WverifiedPutative effector of Rab GTPase Sec4p, forms a complex withSec4p and t-SNARE Sec9p; involved in exocytosisand docking and fusion of post-Golgi vesicleswith plasma membrane; homolog of Sro77p andDrosophila lgl tumor suppressor 0.030730.10118&radic&radic&radic&radic S000004021YLR031WUncharacterizedHypothetical protein 0.030680.10103&radic&radic&radic&radic S000002490RRP8YDR083WverifiedNucleolar protein involved in rRNA processing, pre-rRNAcleavage at site A2; also involved in telomeremaintenance; mutation is synthetically lethalwith a gar1 mutation 0.030620.10086&radic&radic&radic&radic&radic S000000106YBL010CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles 0.030580.10072&radic&radic&radic&radic S000006114RSA1YPL193WverifiedProtein involved in the assembly of 60S ribosomal subunits;functionally interacts with Dbp6p; functions ina late nucleoplasmic step of the assembly 0.030560.10065&radic S000005862ALA1YOR335CverifiedCytoplasmic alanyl-tRNA synthetase, required for proteinsynthesis; point mutation (cdc64-1 allele)causes cell cycle arrest at G1; lethality ofnull mutation is functionally complemented byhuman homolog 0.030460.10029&radic&radic S000006343VPS66YPR139CverifiedCytoplasmic protein of unknown function involved in vacuolarprotein sorting. 0.030460.10029&radic&radic&radic S000001756NAP1YKR048CverifiedProtein that interacts with mitotic cyclin Clb2p; required forthe regulation of microtubule dynamics duringmitosis; controls bud morphogenesis; involvedin the transport of H2A and H2B histones to thenucleus 0.030420.10016&radic S000005671PNO1YOR145CverifiedEssential nucleolar protein required for pre-18S rRNAprocessing, interacts with Dim1p, an 18S rRNAdimethyltransferase, and also with Nob1p, whichis involved in proteasome biogenesis; containsa KH domain 0.030420.10016&radic&radic S000003576NUP192YJL039CverifiedEssential structural subunit of the nuclear pore complex (NPC),localizes to the nuclear periphery of nuclearpores, homologous to human p205 0.030370.09991 S000003669MRS3YJL133WverifiedMitochondrial iron transporter of the mitochondrial carrierfamily (MCF), very similar to and functionallyredundant with Mrs4p; functions under low-ironconditions; may transport other cations inaddition to iron &radic0.030340.09991&radic&radic&radic&radic S000004814RAD14YMR201CverifiedProtein that recognizes and binds damaged DNA during nucleotideexcision repair; subunit of Nucleotide ExcisionRepair Factor 1 (NEF1); contains zinc fingermotif; homolog of human XPA protein 0.030310.09975&radic&radic&radic S000001261YHR218WUncharacterizedHelicase-like protein encoded within the telomeric Y' element 0.030250.09954&radic&radic&radic S000005670ELG1YOR144CverifiedProtein required for S phase progression and telomerehomeostasis, forms an alternative replicationfactor C complex important for DNA replicationand genome integrity; involved in homologousrecombination-mediated DNA repair 0.030220.09946&radic&radic S000000118PIM1YBL022CverifiedMitochondrial ATP-dependent protease involved inintramitochondrial proteolysis; involved indegradation of misfolded proteins inmitochondria; required for bigenesis andmaintenance of mitochondria 0.03020.09943&radic&radic&radic S000001664PRS1YKL181Wverified5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involvedin nucleotide, histidine, and tryptophanbiosynthesis; one of five related enzymes,which are active as heteromultimeric complexes 0.03020.09943&radic S000000286UBC4YBR082CverifiedUbiquitin-conjugating enzyme that mediates degradation ofshort-lived and abnormal proteins; interactswith E3-CaM in ubiquitinating calmodulin;interacts with many SCF ubiquitin proteinligases; component of the cellular stressresponse 0.030150.09921&radic S000003262POP6YGR030CverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends 0.030190.09921&radic&radic&radic S000001608RRN3YKL125WverifiedProtein required for transcription of rDNA by RNA polymerase I;transcription factor independent of DNAtemplate; involved in recruitment of RNApolymerase I to rDNA 0.030080.09901&radic&radic&radic&radic&radic S000005577YOR051CUncharacterizedNuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts 0.029980.09859&radic S000003744NUC1YJL208CverifiedMajor mitochondrial nuclease, has RNAse and DNA endo- andexonucleolytic activities; has a role inmitochondrial recombination 0.029940.09852&radic S000005720TOA1YOR194CverifiedTFIIA large subunit; involved in transcriptional activation,acts as antirepressor or as coactivator;homologous to largest and second largestsubunits of human and Drosophila TFIIA 0.02990.09828&radic&radic S000006348NOC4YPR144CverifiedNucleolar protein, forms a complex with Nop14p that mediatesmaturation and nuclear export of 40S ribosomalsubunits 0.029930.09828&radic&radic&radic S000003956IRC19YLL033WuncharacterizedPutative protein of unknown function; YLL033W is not anessential gene but mutant is defective in sporeformation; null mutant displays increasedlevels of spontaneous Rad52 foci 0.029850.09815&radic&radic&radic&radic S000005925LSP1YPL004CverifiedPrimary component of eisosomes, which are large immobile patchstructures at the cell cortex associated withendocytosis, along with Pil1p and Sur7p ; nullmutants show activation of Pkc1p/Ypk1p stressresistance pathways 0.029860.09815 S000004871YMR258CUncharacterizedProtein of unknown function with similarity to F-box proteins; physically interacts with Skp1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR258C is not an essential gene 0.029790.09792&radic&radic&radic&radic&radic&radic&radic S000000560KAR4YCL055WverifiedTranscription factor required for gene regulation in repsonseto pheromones; also required during meiosis;exists in two forms, a slower-migrating formmore abundant during vegetative growth and afaster-migrating form induced by pheromone 0.029810.09792&radic&radic&radic&radic&radic&radic&radic S000003796RAD26YJR035WverifiedProtein involved in transcription-coupled repair nucleotideexcision repair of UV-induced DNA lesions;homolog of human CSB protein 0.029770.09785&radic&radic S000003026RAD6YGL058WverifiedUbiquitin-conjugating enzyme (E2), involved in postreplicationrepair (with Rad18p), sporulation, telomeresilencing, and ubiquitin-mediated N-end ruleprotein degradation (with Ubr1p) 0.029730.0977&radic&radic&radic S000000017FUN30YAL019WverifiedProtein whose overexpression affects chromosome stability,potential Cdc28p substrate; homolog of Snf2p;the authentic, non-tagged protein is detectedin highly purified mitochondria inhigh-throughput studies 0.029690.09753&radic S000002820RRP17YDR412WuncharacterizedProtein required for cell viability 0.02970.09753&radic&radic S000004908JNM1YMR294WverifiedComponent of the yeast dynactin complex, consisting of Nip100p,Jnm1p, and Arp1p; required for proper nuclearmigration and spindle partitioning duringmitotic anaphase B 0.029680.09749&radic&radic&radic S000004798HSC82YMR186WverifiedCytoplasmic chaperone of the Hsp90 family, redundant infunction and nearly identical with Hsp82p, andtogether they are essential; expressedconstitutively at 10-fold higher basal levelsthat HSP82 and induced 2-3 fold by heat shock 0.029480.09675&radic&radic&radic S000003621EXO70YJL085WverifiedEssential 70kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which has the essential function ofmediating polarized targeting of secretoryvesicles to active sites of exocytosis 0.029450.09675&radic&radic&radic S000002836YDR428CUncharacterizedPutative alpha/beta-serine hydrolase belonging to the subfamily of hormone-sensitive lipase-like hydrolases 0.029410.09629&radic&radic S000004738RRB1YMR131CverifiedEssential nuclear protein involved in early steps of ribosomebiogenesis; physically interacts with theribosomal protein Rpl3p 0.029450.09629&radic&radic&radic&radic S000002655VHS1YDR247WverifiedCytoplasmic serine/threonine protein kinase; identified as ahigh-copy suppressor of the synthetic lethalityof a sis2 sit4 double mutant, suggesting a rolein G1/S phase progression; homolog of Sks1p 0.029390.09629&radic S000004075ARP6YLR085CverifiedActin-related protein that binds nucleosomes; a component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.029340.09629&radic&radic&radic S000004607TAF4YMR005WverifiedTFIID subunit (48 kDa), involved in RNA polymerase IItranscription initiation; potential Cdc28psubstrate 0.02940.09629 S000002814PDR15YDR406WverifiedATP binding cassette (ABC) transporter of the plasma membrane;general stress response factor implicated incellular detoxification; target of Pdr1p, Pdr3pand Pdr8p transcription regulators; promotercontains a PDR responsive element 0.029350.09629&radic&radic&radic&radic S000006344TAZ1YPR140WverifiedLyso-phosphatidylcholine acyltransferase, required for normalphospholipid content of mitochondrialmembranes; may remodel acyl groups ofcardiolipin in the inner membrane; similar tohuman tafazzin, which is implicated in Barthsyndrome 0.02930.09612&radic&radic&radic S000003193VRG4YGL225WverifiedGolgi GDP-mannose transporter; regulates Golgi function andglycosylation in Golgi 0.029270.09603&radic&radic&radic S000000467SHM1YBR263WverifiedMitochondrial serine hydroxymethyltransferase, involved inone-carbon metabolism 0.029250.09588 S000001246RPS4BYHR203CverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps4Ap and has similarity to ratS4 ribosomal protein 0.029190.09578 S000000440ABD1YBR236CverifiedMethyltransferase, catalyzes the transfer of a methyl groupfrom S-adenosylmethionine to the GpppN terminusof capped mRNA 0.02920.09578&radic&radic&radic&radic&radic&radic S000005990BTS1YPL069CverifiedGeranylgeranyl diphosphate synthase, increases theintracellular pool of geranylgeranyldiphosphate, suppressor of bet2 mutation thatcauses defective geranylgeranylation of smallGTP-binding proteins that mediate vesiculartraffic 0.029170.09571&radic S000001800SRP40YKR092CverifiedNucleolar, serine-rich protein with a role in preribosomeassembly or transport; may function as achaperone of small nucleolar ribonucleoproteinparticles (snoRNPs); immunologically andstructurally to rat Nopp140 0.029180.09571 S000004315CWC24YLR323CverifiedEssential protein, component of a complex containing Cef1p; hassimilarity to S. pombe Cwf24p 0.029080.09542&radic S000003651ASF1YJL115WverifiedNucleosome assembly factor, involved in chromatin assembly anddisassembly, anti-silencing protein that causesderepression of silent loci when overexpressed 0.029020.09516&radic&radic&radic S000005151RIO2YNL207WverifiedEssential serine kinase involved in the processing of the 20Spre-rRNA into mature 18S rRNA; has similarityto Rio1p 0.029020.09516&radic S000001215SPC97YHR172WverifiedComponent of the microtubule-nucleating Tub4p (gamma-tubulin)complex; interacts with Spc110p at the spindlepole body (SPB) inner plaque and with Spc72p atthe SPB outer plaque 0.028970.09496&radic&radic&radic S000004924GAS1YMR307WverifiedBeta-1.3-glucanosyltransferase, required for cell wallassembly; localizes to the cell surface via aglycosylphosphatidylinositol (GPI) anchor 0.028970.09496 S000003446RPS0AYGR214WverifiedProtein component of the small (40S) ribosomal subunit, nearlyidentical to Rps0Bp; required for maturation of18S rRNA along with Rps0Bp; deletion of eitherRPS0 gene reduces growth rate, deletion of bothgenes is lethal 0.028920.09483&radic S000006333SCD6YPR129WverifiedProtein containing an Lsm domain, may bind RNA and have a rolein RNA processing; overproduction suppresses anull mutation in CHC1, which encodes the heavychain of clathrin 0.028940.09483&radic&radic S000000165AST1YBL069WverifiedPeripheral membrane protein that interacts with the plasmamembrane ATPase Pma1p and has a role in itstargeting to the plasma membrane, possibly byinfluencing its incorporation into lipid rafts 0.028940.09483&radic&radic&radic&radic S000002873RMT2YDR465CverifiedArginine methyltransferase; ribosomal protein L12 is asubstrate 0.028880.09459&radic&radic&radic S000006393SKI3YPR189WverifiedProtein involved in exosome mediated 3' to 5' mRNA degradationand translation inhibition of non-poly(A)mRNAs; forms complex with Ski2p and Ski8p;required for repressing propagation of dsRNAviruses 0.028820.09442&radic&radic&radic&radic&radic S000001388STH1YIL126WverifiedATPase component of the ATP-dependent RSC chromatin remodelingcomplex required for kinetochore function inchromosome segregation; required for expressionof early meiotic genes; essentialhelicase-related protein homologous to Snf2p 0.02880.09439&radic S000001460MRS1YIR021WverifiedProtein required for the splicing of two mitochondrial group Iintrons (BI3 in COB and AI5beta in COX1); formsa splicing complex, containing four subunits ofMrs1p and two subunits of the BI3-encodedmaturase, that binds to the BI3 RNA &radic0.02880.09439&radic S000005623YOR097CUncharacterizedHypothetical protein 0.028780.09428 S000005548YOR022CUncharacterizedHypothetical protein 0.028770.09418&radic&radic&radic&radic&radic S000000141COR1YBL045CverifiedCore subunit of the ubiquinol-cytochrome c reductase complex(bc1 complex), which is a component of themitochondrial inner membrane electron transportchain 0.028750.09415 S000001338SEC28YIL076WverifiedEpsilon-COP subunit of the coatomer; regulates retrogradeGolgi-to-ER protein traffic; stabilizes Cop1p,the alpha-COP and the coatomer complex;non-essential for cell growth 0.028740.09415&radic S000003925RTT109YLL002WverifiedProtein with a role in regulation of Ty1 transposition 0.028720.09402&radic&radic&radic&radic&radic S000001486MRP17YKL003CverifiedMitochondrial ribosomal protein of the small subunit; MRP17exhibits genetic interactions with PET122,encoding a COX3-specific translationalactivator 0.028690.0939&radic&radic S000000168RPS8AYBL072CverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps8Bp and has similarity to ratS8 ribosomal protein 0.028670.09384&radic&radic S000001725YKR017CUncharacterizedPutative protein of unknown function; contains a RING finger motif 0.028650.09378&radic&radic&radic&radic S000004057PET309YLR067CverifiedSpecific translational activator for the COX1 mRNA, alsoinfluences stability of intron-containing COX1primary transcripts; located in themitochondrial inner membrane 0.028640.09378&radic&radic&radic S000002157NHP6BYBR089C-AverifiedHigh-mobility group non-histone chromatin protein, functionallyredundant with Nhp6Ap; homologous to mammalianhigh mobility group proteins 1 and 2; acts torecruit transcription factor Rcs1p to certainpromoters 0.028640.0937&radic&radic&radic S000003308MRPL25YGR076CverifiedMitochondrial ribosomal protein of the large subunit 0.028630.0937&radic&radic&radic&radic S000002492AFR1YDR085CverifiedAlpha-factor pheromone receptor regulator, negatively regulatespheromone receptor signaling; required fornormal mating projection (shmoo) formation;interacts with Cdc12p 0.028640.0937&radic&radic S000005361PHO80YOL001WverifiedCyclin, negatively regulates phosphate metabolism;Pho80p-Pho85p (cyclin-CDK complex)phosphorylates Pho4p and Swi5p; deletion ofPHO80 leads to aminoglycoside supersensitivity;truncated form of PHO80 affects vacuoleinheritance 0.028610.09357&radic S000004546YML081WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YML081w is not an essential gene 0.028570.09349&radic S000002528DPB4YDR121WverifiedShared subunit of DNA polymerase epsilon and of ISW2/yCHRACchromatin accessibility complex; involved inboth chromosomal DNA replication and ininheritance of telomeric silencing 0.028550.09326&radic&radic S000003865SOD1YJR104CverifiedCytosolic superoxide dismutase; some mutations are analogous tothose that cause ALS (amyotrophic lateralsclerosis) in humans 0.028530.09326&radic S000001334HOP1YIL072WverifiedMeiosis-specific DNA binding protein that displays Red1pdependent localization to the unsynapsedaxial-lateral elements of the synaptonemalcomplex; required for homologous chromosomesynapsis and chiasma formation 0.028550.09326&radic&radic&radic&radic S000004322CHS5YLR330WverifiedProtein involved in export from the Golgi to plasma membrane;involved in chitin biosynthesis through itsrole in Chs3p localization; interacts withArf1p, Bch1p, Fmp50p, Bud7p, and Chs6p 0.028520.09326 S000006003MOT1YPL082CverifiedEssential abundant protein involved in regulation oftranscription, removes Spt15p (TBP) from DNAvia its C-terminal ATPase activity, forms acomplex with TBP that binds TATA DNA with highaffinity but with altered specificity 0.028540.09326&radic S000001747GAP1YKR039WverifiedGeneral amino acid permease; localization to the plasmamembrane is regulated by nitrogen source 0.028460.09297 S000001597APN1YKL114CverifiedMajor apurinic/apyrimidinic endonuclease, 3'-repair diesteraseinvolved in repair of DNA damage by oxidationand alkylating agents; also functions as a3'-5' exonuclease to repair7,8-dihydro-8-oxodeoxyguanosine 0.028390.09271&radic&radic&radic&radic S000005958EGD1YPL037CverifiedSubunit beta1 of the nascent polypeptide-associated complex(NAC) involved in protein targeting, associatedwith cytoplasmic ribosomes; enhances DNAbinding of the Gal4p activator; homolog ofhuman BTF3b 0.028410.09271&radic S000006298RDS3YPR094WverifiedZinc cluster protein involved in pre-mRNA splicing andcycloheximide resistance &radic0.028360.09269&radic&radic S000004352VPS38YLR360WverifiedPart of a Vps34p phosphatidylinositol 3-kinase complex thatfunctions in carboxypeptidase Y (CPY) sorting;binds Vps30p and Vps34p to promote productionof phosphatidylinositol 3-phosphate (PtdIns3P)which stimulates kinase activity 0.028320.09255&radic&radic&radic&radic&radic S000002276YDL118WUncharacterizedNon-essential protein of unconfirmed function; mutants are defective in telomere maintenance, and are synthetically sick or lethal with alpha-synuclein 0.028290.09241&radic S000000183RPL23AYBL087CverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl23Bp and has similarity to E.coli L14 and rat L23 ribosomal proteins 0.02830.09241&radic&radic&radic&radic S000004282GCD7YLR291CverifiedBeta subunit of the translation initiation factor eIF2B, theguanine-nucleotide exchange factor for eIF2;activity subsequently regulated byphosphorylated eIF2; first identified as anegative regulator of GCN4 expression 0.028260.09231&radic S000003268CAX4YGR036CverifiedDolichyl pyrophosphate (Dol-P-P) phosphatase with a luminallyoriented active site in the ER, cleaves theanhydride linkage in Dol-P-P, required forDol-P-P-linked oligosaccharide intermediatesynthesis and protein N-glycosylation 0.028270.09231&radic&radic&radic S000001090YHR048WUncharacterizedPutative protein of unknown function, has similarity to multidrug resistance proteins; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles 0.028280.09231&radic S000001006YLF2YHL014CverifiedProtein of unknown function, has weak similarity to E. coliGTP-binding protein gtp1; the authentic,non-tagged protein is detected in highlypurified mitochondria in high-throughputstudies 0.028210.09207&radic&radic&radic S000001640APE2YKL157WverifiedZinc-dependent metallopeptidase yscII, may have a role inobtaining leucine from dipeptide substrates;sequence coordinates have changed since RT-PCRanalysis showed that the adjacent ORF YKL158Wcomprises the 5' exon of APE2/YKL157W 0.028160.0919&radic&radic S000000052GPB2YAL056WverifiedProposed beta subunit of the heterotrimeric G protein;interacts with the receptor Grp1p, affectssignaling by altering the level ofphosphorylation of PKS substrates; regulatespseudohyphal growth through cAMP levels;homolog of Gpb1p 0.028090.09166 S000005582NOB1YOR056CverifiedEssential nuclear protein involved in proteasome maturation andsynthesis of 40S ribosomal subunits; requiredfor cleavage of the 20S pre-rRNA to generatethe mature 18S rRNA 0.028080.09162&radic&radic S000001131GAR1YHR089CverifiedProtein component of the H/ACA snoRNP pseudouridylase complex,involved in the modification and cleavage ofthe 18S pre-rRNA 0.028060.09158 S000003428FYV8YGR196CverifiedProtein of unknown function, required for survival uponexposure to K1 killer toxin 0.028050.09153 S000005092ALF1YNL148CverifiedAlpha-tubulin folding protein, similar to mammalian cofactor B;Alf1p-GFP localizes to cytoplasmicmicrotubules; required for the folding ofalpha-tubulin and may play an additional rolein microtubule maintenance 0.028040.09152&radic&radic S000003201TAN1YGL232WverifiedPutative tRNA acetyltransferase, RNA-binding protein requiredfor the formation of the modified nucleosideN(4)-acetylcytidine in serine and leucine tRNAsbut not required for the same modification in18S rRNA 0.028040.0915&radic&radic&radic&radic&radic S000006338MSS18YPR134WverifiedNuclear encoded protein needed for efficient splicing ofmitochondrial COX1 aI5beta intron; mss18mutations block cleavage of 5' exon - intronjunction; phenotype of intronless strainsuggests additional functions &radic0.028020.09138&radic&radic&radic&radic S000003949HSP104YLL026WverifiedHeat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p(Hsp70) to refold and reactivate previouslydenatured, aggregated proteins; responsive tostresses including: heat, ethanol, and sodiumarsenite; involved in [PSI+] propagation 0.027930.0911&radic&radic&radic&radic S000002890CWC21YDR482CverifiedComponent of a complex containing Cef1p, putatively involved inpre-mRNA splicing; may bind RNA; has similarityto S. pombe Cwf21p 0.027920.09108&radic S000002411RAD57YDR004WverifiedProtein that stimulates strand exchange by stabilizing thebinding of Rad51p to single-stranded DNA;involved in the recombinational repair ofdouble-strand breaks in DNA during vegetativegrowth and meiosis; forms heterodimer withRad55p 0.02790.091&radic S000001439YIL177CUncharacterizedPutative protein of unknown function; similarity to DNA helicases that are encoded within subtelomeric Y' elements and induced in telomerase deficient survivors 0.027870.0909 S000004231YLR241WUncharacterizedHypothetical protein 0.027890.0909&radic&radic&radic&radic S000005809YOR283WUncharacterizedPutative protein of unknown function with some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene 0.027830.09067&radic&radic&radic&radic&radic&radic S000002285PCL2YDL127WverifiedG1 cyclin, associates with Pho85p cyclin-dependent kinase (Cdk)to contribute to entry into the mitotic cellcycle, essential for cell morphogenesis;localizes to sites of polarized cell growth 0.027810.09067&radic&radic S000003326VAS1YGR094WverifiedMitochondrial and cytoplasmic valyl-tRNA synthetase 0.027840.09067&radic&radic&radic&radic S000002575CDC37YDR168WverifiedEssential Hsp90p co-chaperone; necessary for passage throughthe START phase of the cell cycle 0.027820.09067&radic&radic S000001259IMD2YHR216WverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, expression is induced bymycophenolic acid resulting in resistance tothe drug, expression is repressed by nutrientlimitation 0.027810.09065&radic&radic&radic S000001935YFR039CUncharacterizedPutative protein of unknown function; YFR039C is not an essential gene 0.027780.09055 S000002432RPS11AYDR025WverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps11Bp and has similarity to E.coli S17 and rat S11 ribosomal proteins 0.027710.09001&radic S000003703ERG20YJL167WverifiedFarnesyl pyrophosphate synthetase, has bothdimethylallyltranstransferase andgeranyltranstransferase activities; catalyzesthe formation of C15 farnesyl pyrophosphateunits for isoprenoid and sterol biosynthesis 0.027640.09001&radic&radic&radic S000001939IRC6YFR043CuncharacterizedHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 0.027690.09001&radic&radic&radic&radic&radic S000000287TEC1YBR083WverifiedTranscription factor required for full Ty1 epxression,Ty1-mediated gene activation, and haploidinvasive and diploid pseudohyphal growth;TEA/ATTS DNA-binding domain family member 0.027660.09001&radic&radic&radic&radic S000004520IMD4YML056CverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 0.027690.09001 S000000172ILS1YBL076CverifiedCytoplasmic isoleucine-tRNA synthetase, target of theG1-specific inhibitor reveromycin A 0.027610.08987&radic S000001052RPL27AYHR010WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl27Bp and has similarity to ratL27 ribosomal protein 0.027610.08987&radic&radic&radic&radic&radic&radic S000000295MRS5YBR091CverifiedEssential protein of the inner mitochondrial membrane,peripherally localized; component of the TIM22complex, which is a twin-pore translocase thatmediates insertion of numerous multispanninginner membrane proteins 0.027630.08987 S000004433RPS1AYLR441CverifiedRibosomal protein 10 (rp10) of the small (40S) subunit; nearlyidentical to Rps1Bp and has similarity to ratS3a ribosomal protein 0.02760.08984&radic&radic S000001195SPO12YHR152WverifiedNucleolar protein of unknown function, positive regulator ofexit from mitosis; involved in regulating therelease of Cdc14p from the nucleolus in earlyanaphase; proposed to play similar role inmeiosis 0.027580.08972&radic&radic S000002569NBP2YDR162CverifiedProtein involved in the HOG (high osmolarity glycerol) pathway,negatively regulates Hog1p by recruitment ofphosphatase Ptc1p the Pbs2p-Hog1p complex,found in the nucleus and cytoplasm, contains anSH3 domain that binds Pbs2p 0.027540.08965&radic&radic S000005256RFA2YNL312WverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 0.027510.08959&radic&radic&radic S000005782TRE2YOR256CverifiedProtein of unknown function with similarity to TRE1/YPL176C;required for cell viability 0.02750.08955&radic&radic&radic&radic&radic S000000884UTP7YER082CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.027490.0895&radic&radic&radic&radic&radic S000004691YMR086C-ADubiousHypothetical protein 0.02750.0895&radic&radic&radic&radic S000004630TAP42YMR028WverifiedEssential protein involved in the TOR signaling pathway;physically associates with the proteinphosphatase 2A and the SIT4 protein phosphatasecatalytic subunits 0.027470.08944&radic&radic&radic&radic S000002603REF2YDR195WverifiedRNA-binding protein involved in the cleavage step of mRNA3'-end formation prior to polyadenylation, andin snoRNA maturation; part of holo-CPFsubcomplex APT, which associates with 3'-endsof snoRNA- and mRNA-encoding genes 0.027450.08934&radic&radic&radic S000003488GND2YGR256Wverified6-phosphogluconate dehydrogenase (decarboxylating), catalyzesan NADPH regenerating reaction in the pentosephosphate pathway; required for growth onD-glucono-delta-lactone 0.027460.08934&radic&radic&radic&radic S000004122YLR132CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to mitochondria and nucleus; YLR132C is an essential gene &radic0.027410.08919&radic&radic S000000114POP8YBL018CverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends 0.027390.08911&radic&radic&radic S000001493UFD4YKL010CverifiedUbiquitin-protein ligase (E3) that interacts with Rpt4p andRpt6p, two subunits of the 19S particle of the26S proteasome; cytoplasmic E3 involved in thedegradation of ubiquitin fusion proteins 0.02740.08911&radic&radic&radic&radic&radic&radic S000006260TFB4YPR056WverifiedSubunit of TFIIH complex, involved in transcription initiation,similar to 34 kDa subunit of human TFIIH;interacts with Ssl1p 0.027380.08907&radic&radic&radic&radic S000004602YML133CUncharacterizedPutative protein of unknown function with similarity to helicases; localized to mitochondria; YML133C contains an intron 0.027360.08899 S000002224IDP1YDL066WverifiedMitochondrial NADP-specific isocitrate dehydrogenase, catalyzesthe oxidation of isocitrate toalpha-ketoglutarate; not required formitochondrial respiration and may function todivert alpha-ketoglutarate to biosyntheticprocesses 0.027330.08889 S000004204FRE1YLR214WverifiedFerric reductase and cupric reductase, reducessiderophore-bound iron and oxidized copperprior to uptake by transporters; expressioninduced by low copper and iron levels 0.027310.08875&radic&radic S000001028MUP3YHL036WverifiedLow affinity methionine permease, similar to Mup1p 0.027270.0886&radic&radic&radic&radic S000005171JJJ1YNL227CverifiedProtein that contains a 70 amino acid J-domain, may function asa co-chaperone to recruit Hsp70-like activityto specific sites; mutation causes defects influid-phase endocytosis 0.02730.0886&radic&radic&radic S000003413TIM13YGR181WverifiedMitochondrial intermembrane space protein, forms a complex withTIm8p that mediates import and insertion of asubset of polytopic inner membrane proteins;may prevent aggregation of incoming proteins ina chaperone-like manner 0.027290.0886&radic&radic&radic&radic&radic&radic S000006014NOG1YPL093WverifiedPutative GTPase that associates with free 60S ribosomalsubunits in the nucleolus and is required for60S ribosomal subunit biogenesis; constituentof 66S pre-ribosomal particles; member of theODN family of nucleolar G-proteins 0.027250.08855&radic&radic&radic S000002773ESF1YDR365CverifiedNucleolar protein involved in pre-rRNA processing; depletioncauses severely decreased 18S rRNA levels 0.027230.0884&radic&radic S000004844PEP5YMR231WverifiedPeripheral vacuolar membrane protein required for proteintrafficking and vacuole biogenesis; formscomplex with Pep3p that promotes vesiculardocking/fusion reactions in conjunction withSNARE proteins, also interacts with Pep7p 0.027230.0884&radic&radic&radic&radic&radic S000005224ERG24YNL280CverifiedC-14 sterol reductase, acts in ergosterol biosynthesis; mutantsaccumulate the abnormal sterol ignosterol(ergosta-8,14 dienol), and are viable underanaerobic growth conditions but inviable onrich medium under aerobic conditions 0.027210.08836 S000003269ACB1YGR037CverifiedAcyl-CoA-binding protein, transports newly synthesized acyl-CoAesters from fatty acid synthetase (Fas1p-Fas2p)to acyl-CoA-consuming processes 0.027170.08819&radic&radic S000000805PMI40YER003CverifiedMannose-6-phosphate isomerase, catalyzes the interconversion offructose-6-P and mannose-6-P; required forearly steps in protein mannosylation 0.027150.08818&radic S000004771HLJ1YMR161WverifiedCo-chaperone for Hsp40p, anchored in the ER membrane; with itshomolog Hdj1p promotes ER-associated proteindegradation (ERAD) of integral membranesubstrates; similar to E. coli DnaJ 0.027140.08808&radic&radic S000004926NIP1YMR309CverifiedSubunit of the eukaryotic translation initiation factor 3(eIF3), involved in the assembly ofpreinitiation complex and start codon selection 0.027120.08787&radic S000003453TOS2YGR221CverifiedProtein involved in localization of Cdc24p to the site of budgrowth; may act as a membrane anchor; localizesto the bud neck and bud tip; potentiallyphosphorylated by Cdc28p 0.027090.08787&radic&radic&radic&radic S000001554YKL071WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.02710.08787&radic&radic&radic S000006364GPH1YPR160WverifiedNon-essential glycogen phosphorylase required for themobilization of glycogen, activity is regulatedby cyclic AMP-mediated phosphorylation,expression is regulated by stress-responseelements and by the HOG MAP kinase pathway 0.027060.08778&radic&radic S000004870PET111YMR257CverifiedSpecific translational activator for the COX2 mRNA, located inthe mitochondrial inner membrane 0.027060.08778&radic&radic&radic S000001945YMR31YFR049WverifiedMitochondrial ribosomal protein of the small subunit, hassimilarity to human mitochondrial ribosomalprotein MRP-S36 0.027010.08763&radic S000002995CWH41YGL027CverifiedProcessing alpha glucosidase I, ER type II integral membraneN-glycoprotein involved in assembly of cellwall beta 1,6 glucan and asparagine-linkedprotein glycosylation; also involved in ERprotein quality control and sensing of ERstress 0.026970.08745&radic S000005136CHS1YNL192WverifiedChitin synthase I, requires activation from zymogenic f