Yfunc lets you browse current and predicted gene functions in yeast

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Prediction of GO:0008757 "S-adenosylmethionine-dependent methyltransferase activity"

GO branch: MF
Number of currently annotated genes: 62

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest Huh:nucleusHarbison:IME1_H2O2HiLum:ClotrimazoleLum:GliotoxinTAP:65Huh:cytoplasmLum:Valproic AcidHarbison:MBF1_YPDLum:GemfibrozilHarbison:IME1_YPD S000001161SET1YHR119WverifiedHistone methyltransferase, subunit of the COMPASS (Set1C)complex which methylates histone H3 on lysine4; required in transcriptional silencing neartelomeres and at the silent mating type loci;contains a SET domain &radic0.495540.94505&radic&radic S000000064SWD1YAR003WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres; WD40beta propeller superfamily member withsimilarity to mammalian Rbbp7 &radic0.448960.93469&radic&radic&radic&radic S000002877SDC1YDR469WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres; hassimilarity to C. elegans Dpy-30 &radic0.396550.93469&radic&radic&radic&radic S000004005BRE2YLR015WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres;involved in telomere maintenance; similar totrithorax-group protein ASH2L &radic0.397190.93469&radic&radic&radic&radic S000000379SWD3YBR175WverifiedEssential subunit of the COMPASS (Set1C) complex, whichmethylates histone H3 on lysine 4 and isrequired in transcriptional silencing neartelomeres; WD40 beta propeller superfamilymember and ortholog of mammalian WDR5 &radic0.451510.93469&radic&radic&radic&radic&radic&radic S000006059SPP1YPL138CverifiedSubunit of COMPASS (Set1C), a complex which methylates histoneH3 on lysine 4 and is required in telomerictranscriptional silencing; PHD finger domainprotein similar to human CGBP, an unmethylatedCpG binding protein &radic0.344510.91985&radic&radic&radic&radic&radic&radic S000004467ERG6YML008CverifiedDelta(24)-sterol C-methyltransferase, converts zymosterol tofecosterol in the ergosterol biosyntheticpathway by methylating position C-24; localizedto both lipid particles and mitochondrial outermembrane &radic0.301290.89373&radic&radic&radic S000004476TRM9YML014WverifiedtRNA methyltransferase, catalyzes the esterification ofmodified uridine nucleotides in tRNAs, creating5-methylcarbonylmethyluridine in tRNA(Arg3) and5-methylcarbonylmethyl-2-thiouridine intRNA(Glu); may have a role in stress response 0.297180.89039&radic&radic&radic&radic&radic S000000977TMT1YER175CverifiedTrans-aconitate methyltransferase, cytosolic enzyme thatcatalyzes the methyl esterification of3-isopropylmalate, an intermediate of theleucine biosynthetic pathway, andtrans-aconitate, which inhibits the citric acidcycle &radic0.267590.88238&radic S000005765ABP140YOR239WverifiedNonessential protein that binds actin filaments and localizesto actin patches and cables, has similarity toS-adenosylmethionine (AdoMet)-dependentmethyltransferases &radic0.269320.88238&radic&radic&radic&radic&radic S000002724OMS1YDR316WverifiedProtein integral to the mitochondrial membrane; has a conservedmethyltransferase motif; multicopy suppressorof respiratory defects caused by OXA1 mutations &radic0.268780.88238&radic&radic S000005456COQ3YOL096CverifiedO-methyltransferase, catalyzes two different O-methylationsteps in ubiquinone (Coenzyme Q) biosynthesis;component of a mitochondrialubiquinone-synthesizing complex &radic0.264410.87907&radic&radic S000002476DOA4YDR069CverifiedUbiquitin hydrolase, required for recycling ubiquitin fromproteasome-bound ubiquitinated intermediates,acts at the late endosome/prevacuolarcompartment to recover ubiquitin fromubiquitinated membrane proteins en route to thevacuole 0.261550.87768&radic&radic&radic S000003874RSM7YJR113CverifiedMitochondrial ribosomal protein of the small subunit, hassimilarity to E. coli S7 ribosomal protein 0.253520.87581 S000001106SSZ1YHR064CverifiedHsp70 protein that interacts with Zuo1p (a DnaJ homolog) toform a ribosome-associated complex that bindsthe ribosome via the Zuo1p subunit; alsoinvolved in pleiotropic drug resistance viasequential activation of PDR1 and PDR5; bindsATP 0.236510.85989&radic&radic&radic S000004940YMR321CUncharacterizedHypothetical protein 0.19930.82557 S000001326YIL064WUncharacterizedPutative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family &radic0.190760.81544&radic&radic&radic S000000265TRM7YBR061Cverified2'-O-ribose methyltransferase, methylates the 2'-O-ribose ofnucleotides at positions 32 and 34 of the tRNAanticodon loop 0.18010.80505&radic&radic&radic S000001252CRG1YHR209WuncharacterizedPutative S-adenosylmethionine-dependent methyltransferase;mediates cantharidin resistance &radic0.177720.8015&radic&radic&radic&radic&radic S000000643BUD23YCR047CverifiedProtein involved in bud-site selection; diploid mutants displaya random budding pattern instead of thewild-type bipolar pattern &radic0.175990.8&radic&radic S000000560KAR4YCL055WverifiedTranscription factor required for gene regulation in repsonseto pheromones; also required during meiosis;exists in two forms, a slower-migrating formmore abundant during vegetative growth and afaster-migrating form induced by pheromone 0.163190.78487&radic&radic&radic&radic&radic&radic S000003233YGR001CUncharacterizedPutative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae 0.151870.77132&radic&radic&radic S000002547MTQ2YDR140WuncharacterizedS-adenosylmethionine-dependent methyltransferase of the sevenbeta-strand family; methylates release factoreRF1 (Sup45p) in vitro; is not an essentialgene; similar to E.coli PrmC &radic0.147880.76415&radic&radic&radic&radic&radic&radic S000005484TRM11YOL124CverifiedCatalytic subunit of an adoMet-dependent tRNA methyltransferasecomplex (Trm11p-Trm112p), required for themethylation of the guanosine nucleotide atposition 10 (m2G10) in tRNAs; contains a THUMPdomain and a methyltransferase domain &radic0.141150.75457&radic&radic&radic S000004464TRM12YML005WverifiedS-adenosylmethionine-dependent methyltransferase of the sevenbeta-strand family; required for wybutosineformation in phenylalanine-accepting tRNA &radic0.135750.74421&radic&radic&radic S000001112TRM5YHR070WverifiedtRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacentto the anticodon that has a role in preventionof frameshifting; highly conserved acrossArchaea, Bacteria, and Eukarya &radic0.130290.738&radic&radic&radic&radic&radic S000004822YMR209CUncharacterizedPutative protein of unknown function; YMR209C is not an essential gene 0.125450.729&radic S000006187DIM1YPL266WverifiedEssential 18S rRNA dimethylase, responsible for conservedm6(2)Am6(2)A dimethylation in 3'-terminal loopof 18 S rRNA, part of 90S and 40S pre-particlesin nucleolus, involved in pre-ribosomal RNAprocessing &radic0.116630.71305&radic&radic&radic&radic S000004967YNL022CUncharacterizedPutative protein of unknown function with seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to a single spot in the nucleus; YNL022C is not an essential gene 0.111970.70262&radic&radic&radic S000006012GLR1YPL091WverifiedCytosolic and mitochondrial glutathione oxidoreductase,converts oxidized glutathione to reducedglutathione 0.103130.68717&radic&radic&radic&radic S000005005NOP2YNL061WverifiedProbable RNA m(5)C methyltransferase, essential for processingand maturation of 27S pre-rRNA and largeribosomal subunit biogenesis; localized to thenucleolus; constituent of 66S pre-ribosomalparticles &radic0.102460.68711&radic&radic S000001876LPD1YFL018CverifiedDihydrolipoamide dehydrogenase, the lipoamide dehydrogenasecomponent (E3) of the pyruvate dehydrogenaseand 2-oxoglutarate dehydrogenase multi-enzymecomplexes 0.095690.67402&radic&radic&radic&radic S000003985MHT1YLL062CverifiedS-methylmethionine-homocysteine methyltransferase, functionsalong with Sam4p in the conversion ofS-adenosylmethionine (AdoMet) to methionine tocontrol the methionine/AdoMet ratio &radic0.089550.65618&radic&radic S000006194SAM4YPL273WverifiedS-adenosylmethionine-homocysteine methyltransferase, functionsalong with Mht1p in the conversion ofS-adenosylmethionine (AdoMet) to methionine tocontrol the methionine/AdoMet ratio &radic0.087230.64871&radic&radic&radic&radic S000005333LYS9YNR050CverifiedSaccharopine dehydrogenase (NADP+, L-glutamate-forming);catalyzes the formation of saccharopine fromalpha-aminoadipate 6-semialdehyde, which is theseventh step in lysine biosynthesis pathway 0.08480.64108&radic&radic S000000559SPB1YCL054WverifiedAdoMet-dependent methyltransferase involved in rRNA processingand 60S ribosomal subunit maturation;methylates G2922 in the tRNA docking site ofthe large subunit rRNA and in the absence ofsnR52, U2921; suppressor of PAB1 mutants &radic0.076690.61689&radic&radic&radic&radic S000001777MET1YKR069WverifiedS-adenosyl-L-methionine uroporphyrinogen III transmethylase,involved in sulfate assimilation, methioninemetabolism, and siroheme biosynthesis &radic0.075120.61117&radic S000005007MTQ1YNL063WuncharacterizedS-adenosylmethionine-dependent Methyltransferase; methylatestranslational release factor Mrf1p; similar toE.coli PrmC; is not an essential gene &radic0.063640.5707&radic S000003704SET2YJL168CverifiedHistone methyltransferase with a role in transcriptionalelongation, methylates a lysine residue ofhistone H3; associates with the C-terminaldomain of Rpo21p; histone methylation activityis regulated by phosphorylation status ofRpo21p &radic0.062450.56679&radic&radic&radic&radic S000000120NCL1YBL024WverifiedS-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase,methylates cytosine to m5C at several positionsin tRNAs and intron-containing pre-tRNAs;similar to Nop2p and human proliferationassociated nucleolar protein p120 &radic0.057970.54748&radic&radic&radic&radic&radic S000004470SPT5YML010WverifiedProtein that forms a complex with Spt4p and mediates bothactivation and inhibition of transcriptionelongation; Spt4p-Spt5p complex also plays arole in pre-mRNA processing 0.052190.51611&radic&radic&radic&radic S000004754TIF34YMR146CverifiedSubunit of the core complex of translation initiation factor3(eIF3), which is essential for translation 0.045640.48918&radic&radic S000004841MTF1YMR228WverifiedMitochondrial RNA polymerase specificity factor with structuralsimilarity to S-adenosylmethionine-dependentmethyltransferases and functional similarity tobacterial sigma-factors, interacts withmitochondrial core polymerase Rpo41p &radic0.045530.48858&radic&radic&radic&radic S000000957BEM2YER155CverifiedRho GTPase activating protein (RhoGAP) involved in the controlof cytoskeleton organization and cellularmorphogenesis; required for bud emergence 0.044730.48165&radic&radic S000002607YDR199WDubiousHypothetical protein 0.043390.47879&radic&radic&radic S000000867ICL1YER065CverifiedIsocitrate lyase, catalyzes the formation of succinate andglyoxylate from isocitrate, a key reaction ofthe glyoxylate cycle; expression of ICL1 isinduced by growth on ethanol and repressed bygrowth on glucose 0.04260.47389&radic&radic S000001219FMO1YHR176WverifiedFlavin-containing monooxygenase, localized to the cytoplasmicface of the ER membrane; catalyzes oxidation ofbiological thiols to maintain the ER redoxbuffer ratio for correct folding ofdisulfide-bonded proteins 0.041540.47091&radic S000000825PRO3YER023WverifiedDelta 1-pyrroline-5-carboxylate reductase, catalyzes the laststep in proline biosynthesis 0.040760.46884&radic&radic&radic S000004045SPT8YLR055CverifiedSubunit of the SAGA transcriptional regulatory complex but notpresent in SAGA-like complex SLIK/SALSA,required for SAGA-mediated inhibition at somepromoters 0.039230.46329&radic&radic&radic&radic&radic S000003322UTP22YGR090WuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.037540.45489&radic&radic S000005228MRPL10YNL284CverifiedMitochondrial ribosomal protein of the large subunit; appearsas two protein spots (YmL10 and YmL18) ontwo-dimensional SDS gels 0.03590.44728&radic S000003104MRM2YGL136CverifiedMitochondrial 21S rRNA methyltransferase, required formethylation of U(2791) in 21S rRNA; MRM2deletion confers thermosensitive respirationand loss of mitochondrial DNA; has similarityto Spb1p and Trm7p, and to E. coli FtsJ/RrmJ &radic0.035490.44465&radic S000000142PSY4YBL046WverifiedPutative regulatory subunit of an evolutionarily conservedprotein phosphatase complex containing thecatalytic subunit Pph3p and a third subunitPsy2p; required for cisplatin resistance;GFP-fusion protein localizes to the nucleus 0.033870.43807&radic S000004401UTP21YLR409CuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.034460.43807&radic&radic&radic S000001308MET30YIL046WverifiedF-box protein containing five copies of the WD40 motif,controls cell cycle function, sulfurmetabolism, and methionine biosynthesis as partof the ubiquitin ligase complex; interacts withand regulates Met4p, localizes within thenucleus 0.032740.43235&radic&radic&radic&radic&radic&radic&radic S000004162DPH5YLR172CverifiedMethyltransferase required for synthesis of diphthamide, whichis a modified histidine residue of translationelongation factor 2 (Eft1p or Eft2p); notessential for viability; GFP-Dph5p fusionprotein localizes to the cytoplasm &radic0.031690.42736&radic&radic&radic&radic S000005025SWS2YNL081CuncharacterizedPutative mitochondrial ribosomal protein of the small subunit,has similarity to E. coli S13 ribosomal protein 0.031730.42736&radic S000005329TRM112YNR046WverifiedSubunit of an adoMet-dependent tRNA methyltransferase (MTase)complex (Trm11p-Trm112p), required for themethylation of the guanosine nucleotide atposition 10 (m2G10) in tRNAs; putative zincbinding subunit of other MTase-related proteins &radic0.031020.42412&radic&radic&radic&radic S000001034YHL042WUncharacterizedPutative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins 0.029740.41568&radic&radic S000000399MSI1YBR195CverifiedSubunit of chromatin assembly factor I (CAF-I), regulates theRAS/cAMP pathway via sequestration of Npr1pkinase; localizes to the nucleus and cytoplasm;homologous to human retinoblastoma bindingproteins RbAp48 and RbAp46 0.02980.41568&radic&radic&radic&radic&radic&radic S000004781YMR171CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to endosomes; mRNA is targeted to the bud via the mRNA transport system involving She2p: YMR171C is not an essential gene 0.029680.41472&radic&radic S000000288MIS1YBR084WverifiedMitochondrial C1-tetrahydrofolate synthase, involved ininterconversion between different oxidationstates of tetrahydrofolate (THF); providesactivities of formyl-THF synthetase,methenyl-THF cyclohydrolase, and methylene-THFdehydrogenase 0.028650.40929 S000002790RPP2BYDR382WverifiedRibosomal protein P2 beta, a component of the ribosomal stalk,which is involved in the interaction betweentranslational elongation factors and theribosome; regulates the accumulation of P1(Rpp1Ap and Rpp1Bp) in the cytoplasm 0.028010.40479&radic&radic&radic S000001504MAK11YKL021CverifiedProtein essential for cell growth and replication of M dsRNAvirus; contains four beta-transducin repeats 0.028070.40479&radic&radic&radic&radic&radic S000000183RPL23AYBL087CverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl23Bp and has similarity to E.coli L14 and rat L23 ribosomal proteins 0.027940.40479&radic&radic&radic&radic&radic S000003432ELP2YGR200CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;target of Kluyveromyces lactis zymocin 0.02760.40353&radic&radic&radic&radic&radic&radic S000001607SSH4YKL124WverifiedProtein whose overexpression confers resistance to the growthinhibitor leflunomide; suppressor of shr3mutation 0.025410.38669&radic&radic S000002761TRR1YDR353WverifiedCytoplasmic thioredoxin reductase, key regulatory enzyme thatdetermines the redox state of the thioredoxinsystem, which acts as a disulfide reductasesystem and protects cells against bothoxidative and reductive stress 0.025080.38461&radic&radic&radic&radic&radic&radic S000003196VID30YGL227WverifiedProtein involved in proteasome-dependent catabolite degradationof fructose-1,6-bisphosphatase (FBPase); shiftsthe balance of nitrogen metabolism toward theproduction of glutamate; localized to thenucleus and the cytoplasm 0.025030.38333&radic&radic&radic&radic&radic S000000470SLM6YBR266CdubiousProtein with a potential role in actin cytoskeletonorganization; gene exhibits synthetic geneticinteraction with MSS4 encodingphosphatidylinositol 4-phosphate kinase 0.024740.37639&radic&radic S000002535YDR128WUncharacterizedHypothetical protein 0.024310.37639&radic S000005732NOC2YOR206WverifiedProtein that forms a nucleolar complex with Mak21p that bindsto 90S and 66S pre-ribosomes, as well as anuclear complex with Noc3p that binds to 66Spre-ribosomes; both complexes mediateintranuclear transport of ribosomal precursors 0.024370.37639&radic&radic&radic&radic S000005552BUB3YOR026WverifiedKinetochore checkpoint WD40 repeat protein that localizes tokinetochores during prophase and metaphase,delays anaphase in the presence of unattachedkinetochores; forms complexes with Mad1p-Bub1pand with Cdc20p, binds Mad2p and Mad3p 0.024570.37639&radic&radic&radic&radic&radic S000002769BCP1YDR361CverifiedEssential protein involved in nuclear export of Mss4p, which isa lipid kinase that generatesphosphatidylinositol 4,5-biphosphate and playsa role in actin cytoskeleton organization andvesicular transport 0.024350.37639&radic&radic&radic&radic&radic S000002787RGA2YDR379WverifiedGTPase-activating protein for the polarity-establishmentprotein Cdc42p; implicated in control of septinorganization, pheromone response, and haploidinvasive growth 0.023610.37027&radic&radic&radic&radic S000003424TDH3YGR192CverifiedGlyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involvedin glycolysis and gluconeogenesis; tetramerthat catalyzes the reaction ofglyceraldehyde-3-phosphate to 1,3bis-phosphoglycerate; detected in the cytoplasmand cell-wall 0.022420.36373&radic&radic&radic&radic S000004119DIP2YLR129WverifiedNucleolar protein, specifically associated with the U3 snoRNA,part of the large ribonucleoprotein complexknown as the small subunit (SSU) processome,required for 18S rRNA biogenesis, part of theactive pre-rRNA processing complex 0.022480.36373&radic&radic&radic&radic S000000782HAT2YEL056WverifiedSubunit of the Hat1p-Hat2p histone acetyltransferase complex;required for high affinity binding of thecomplex to free histone H4, thereby enhancingHat1p activity; similar to human RbAp46 and 48;has a role in telomeric silencing 0.022490.36373&radic&radic&radic&radic S000001805PCK1YKR097WverifiedPhosphoenolpyruvate carboxykinase, key enzyme ingluconeogenesis, catalyzes early reaction incarbohydrate biosynthesis, glucose repressestranscription and accelerates mRNA degradation,regulated by Mcm1p and Cat8p, located in thecytosol 0.021790.35885 S000003367PRE9YGR135Wverified20S proteasome beta-type subunit; the only nonessential 20Ssubunit 0.021560.3569&radic&radic&radic&radic&radic&radic S000001052RPL27AYHR010WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl27Bp and has similarity to ratL27 ribosomal protein 0.021680.3569&radic&radic&radic&radic&radic&radic S000000438ARC40YBR234CverifiedEssential subunit of the ARP2/3 complex, which is required forthe motility and integrity of cortical actinpatches 0.021450.35542&radic&radic&radic&radic S000004914DYN3YMR299CverifiedDynein light intermediate chain (LIC); localizes with dynein,null mutant is defective in nuclear migration 0.021410.35542&radic&radic&radic&radic&radic&radic S000005126IPI3YNL182CuncharacterizedProtein required for cell viability; computational analysis oflarge-scale protein-protein interaction datasuggests a possible role in assembly of theribosomal large subunit 0.021160.35245&radic&radic S000001069RPN1YHR027CverifiedNon-ATPase base subunit of the 19S regulatory particle of the26S proteasome; may participate in therecognition of several ligands of theproteasome; contains a leucine-rich repeat(LRR) domain, a site for protein?proteininteractions 0.020770.35061&radic&radic&radic&radic S000001587GFA1YKL104CverifiedGlutamine-fructose-6-phosphate amidotransferase, catalyzes theformation of glucosamine-6-P and glutamate fromfructose-6-P and glutamine in the first step ofchitin biosynthesis 0.020160.34365&radic&radic S000002482PPH3YDR075WverifiedCatalytic subunit of an evolutionarily conserved proteinphosphatase complex containing Psy2p and theregulatory subunit Psy4p; required forcisplatin resistance; involved in activation ofGln3p 0.019960.3429&radic&radic&radic&radic&radic S000005145PSY2YNL201CverifiedPutative subunit of an evolutionarily conserved proteinphosphatase complex containing the catalyticsubunit Pph3p and the regulatory subunit Psy4p;required for cisplatin and oxaliplatinresistance; localizes to nucleus 0.019930.34286&radic&radic&radic S000005261PFS2YNL317WverifiedIntegral subunit of the pre-mRNA cleavage and polyadenylationfactor (CPF) complex; plays an essential rolein mRNA 3'-end formation by bridging differentprocessing factors and thereby promoting theassembly of the processing complex 0.019850.34096&radic&radic&radic&radic&radic S000001696DOA1YKL213CverifiedWD repeat protein required for ubiquitin-mediated proteindegradation, forms complex with Cdc48p, plays arole in controlling cellular ubiquitinconcentration; also promotes efficient NHEJ inpostdiauxic/stationary phase 0.019430.33852&radic&radic&radic&radic&radic S000000472MRPL37YBR268WverifiedMitochondrial ribosomal protein of the large subunit 0.019490.33852&radic&radic S000002972RPN14YGL004CuncharacterizedPutative non-ATPase subunit of the 19S regulatory particle ofthe 26S proteasome; localized to the cytoplasm 0.018850.3337&radic&radic&radic&radic S000004840TAF7YMR227CverifiedTFIID subunit (67 kDa), involved in RNA polymerase IItranscription initiation 0.018760.33194&radic&radic&radic&radic&radic&radic&radic S000002772CDC40YDR364CverifiedPre-mRNA splicing factor, important for catalytic step II ofpre-mRNA splicing and plays a role in cellcycle progression; required for DNA synthesisduring mitosis and meiosis; has WD repeats 0.018780.33194&radic&radic&radic&radic S000003413TIM13YGR181WverifiedMitochondrial intermembrane space protein, forms a complex withTIm8p that mediates import and insertion of asubset of polytopic inner membrane proteins;may prevent aggregation of incoming proteins ina chaperone-like manner 0.018570.32984&radic&radic&radic&radic S000000104HIR1YBL008WverifiedNon-essential transcriptional corepressor involved in the cellcycle-regulated transcription of histone H2A,H2B, H3 and H4 genes; contributes to nucleosomeformation, heterochromatic gene silencing, andformation of functional kinetochores 0.017990.32607&radic&radic&radic&radic S000002971CDH1YGL003CverifiedCell-cycle regulated activator of the anaphase-promotingcomplex/cyclosome (APC/C), which directsubiquitination of mitotic cyclins resulting inexit from mitosis; targets the APC/C tospecific substrates including CDC20, ASE1 andCIN8 0.018170.32607&radic&radic S000005147YNL203CDubiousHypothetical protein 0.017470.32076&radic&radic&radic&radic S000000307SIF2YBR103WverifiedWD40 repeat-containing subunit of the Set3C histone deacetylasecomplex, which represses early/middlesporulation genes; antagonizes telomericsilencing; binds specifically to the Sir4pN-terminus 0.017080.31766&radic&radic&radic S000000313CMD1YBR109CverifiedCalmodulin; Ca++ binding protein that regulates Ca++independent processes (mitosis, bud growth,actin organization, endocytosis, etc.) and Ca++dependent processes (stress-activatedpathways), targets include Nuf1p, Myo2p andcalcineurin 0.017310.31766&radic S000006382PRP4YPR178WverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.017030.31751&radic&radic&radic&radic&radic S000004798HSC82YMR186WverifiedCytoplasmic chaperone of the Hsp90 family, redundant infunction and nearly identical with Hsp82p, andtogether they are essential; expressedconstitutively at 10-fold higher basal levelsthat HSP82 and induced 2-3 fold by heat shock 0.016930.31684&radic&radic&radic S000000798RMD6YEL072WverifiedProtein required for sporulation 0.016750.31427&radic&radic&radic&radic S000005564HIR2YOR038CverifiedNon-essential transcriptional corepressor involved in the cellcycle-regulated transcription of histone H2A,H2B, H3, and H4 genes; recruits Swi-Snfcomplexes to histone gene promoters; promotesheterochromatic gene silencing with Asf1p 0.016730.31427&radic&radic&radic&radic S000002840NPL3YDR432WverifiedRNA-binding protein that carries poly(A)+ mRNA from the nucleusinto the cytoplasm; phosphorylation by Sky1p inthe cytoplasm may promote release of mRNAs 0.016650.31427&radic&radic&radic&radic&radic&radic&radic&radic S000004198SEC13YLR208WverifiedComponent of both the Nup84 nuclear pore sub-complex and of theCOPII complex (Sar1p, Sec13p, Sec16p, Sec23p,Sec24p, Sec31p, Sfb2p, and Sfb3p) which isimportant for the formation of ER to Golgitransport vesicles 0.016710.31427&radic&radic&radic&radic S000006339CTF4YPR135WverifiedChromatin-associated protein, required for sister chromatidcohesion; interacts with DNA polymerase alpha(Pol1p) and may link DNA synthesis to sisterchromatid cohesion 0.016610.31383&radic&radic S000005197TEX1YNL253WverifiedProtein involved in mRNA export, component of the transcriptionexport (TREX) complex 0.016490.31278&radic&radic&radic S000000402TAF5YBR198CverifiedSubunit (90 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification 0.01630.31017&radic&radic S000000883SER3YER081Wverified3-phosphoglycerate dehydrogenase, catalyzes the first step inserine and glycine biosynthesis; isozyme ofSer33p 0.016270.31017&radic&radic&radic&radic&radic&radic S000005649LEO1YOR123CverifiedComponent of the Paf1 complex, which associates with RNApolymerase II and is involved in histonemethylation 0.016340.31017&radic&radic&radic&radic&radic S000005756WTM1YOR230WverifiedTranscriptional repressor involved in regulation of meiosis andsilencing; contains WD repeats 0.016210.30861&radic&radic&radic&radic S000006021ATG21YPL100WverifiedPhosphatidylinositol 3,5-bisphosphate-binding protein requiredfor maturation of pro-aminopeptidase I,predicted to fold as a seven-bladedbeta-propeller; displays punctate cytoplasmiclocalization 0.016020.30763&radic&radic&radic S000006168YPL247CUncharacterizedHypothetical protein 0.015960.3056&radic&radic&radic&radic S000006130IPL1YPL209CverifiedAurora kinase involved in regulating kinetochore-microtubuleattachments; helps maintain condensedchromosomes during anaphase and earlytelophase; associates with Sli15p, whichpromotes Ipl1p association with mitotic spindle 0.015650.30353&radic&radic&radic&radic&radic S000004212UTP13YLR222CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.015540.30226&radic&radic&radic S000006341RRP9YPR137WverifiedProtein involved in pre-rRNA processing, associated with U3snRNP; component of small ribosomal subunit(SSU) processosome; ortholog of the humanU3-55k protein 0.015280.29992&radic&radic&radic S000002487VPS41YDR080WverifiedVacuolar membrane protein that is a subunit of the homotypicvacuole fusion and vacuole protein sorting(HOPS) complex; essential for membrane dockingand fusion at the Golgi-to-endosome andendosome-to-vacuole stages of protein transport 0.015080.29715&radic&radic S000000544GID7YCL039WverifiedProtein of unknown function, involved in proteasome-dependentcatabolite inactivation offructose-1,6-bisphosphatase; contains six WD40repeats; computational analysis suggests thatGid7p and Moh1p have similar functions 0.015110.29715&radic&radic S000000905SSA4YER103WverifiedHeat shock protein that is highly induced upon stress; plays arole in SRP-dependent cotranslationalprotein-membrane targeting and translocation;member of the HSP70 family; cytoplasmic proteinthat concentrates in nuclei upon starvation 0.015160.29715&radic S000004778CEP3YMR168CverifiedEssential kinetochore protein, component of the CBF3 complexthat binds the CDEIII region of the centromere;contains an N-terminal Zn2Cys6 type zinc fingerdomain, a C-terminal acidic domain, and aputative coiled coil dimerization domain 0.014210.28728&radic&radic S000000124YBL028CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis 0.014170.28728&radic&radic&radic S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling 0.014010.28429&radic&radic&radic&radic&radic&radic&radic&radic S000002494RRP1YDR087CverifiedEssential evolutionarily conserved nucleolar protein necessaryfor biogenesis of 60S ribosomal subunits andprocessing of pre-rRNAs to mature rRNAs,associated with several distinct 66Spre-ribosomal particles 0.013870.28407&radic&radic&radic&radic&radic S000005738STE4YOR212WverifiedG protein beta subunit, forms a dimer with Ste18p to activatethe mating signaling pathway, forms aheterotrimer with Gpa1p and Ste18p to dampensignaling; may recruit Rho1p to the polarizedgrowth site during mating; contains WD40repeats 0.013690.28107&radic&radic&radic&radic S000004559GIM5YML094WverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.013350.27697&radic&radic&radic S000005527RRP6YOR001WverifiedExonuclease component of the nuclear exosome; contributes tothe quality-control system that retains anddegrades aberrant mRNAs in the nucleus 0.013460.27697&radic&radic&radic&radic&radic S000000912KAP123YER110CverifiedKaryopherin beta, mediates nuclear import of ribosomal proteinsprior to assembly into ribosomes and import ofhistones H3 and H4; localizes to the nuclearpore, nucleus, and cytoplasm; exhibits geneticinteractions with RAI1 0.013190.27549&radic&radic&radic S000004279MEC3YLR288CverifiedDNA damage and meiotic pachytene checkpoint protein; subunit ofa heterotrimeric complex (Rad17p-Mec3p-Ddc1p)that forms a sliding clamp, loaded onto partialduplex DNA by a clamp loader complex; homologof human and S. pombe Hus1 0.013110.27519&radic&radic&radic S000006072PRP46YPL151CverifiedSplicing factor that is found in the Cef1p subcomplex of thespliceosome 0.013080.27483&radic&radic&radic&radic S000002611YDR203WDubiousHypothetical protein 0.013040.27397&radic&radic&radic&radic S000005755WTM2YOR229WverifiedTranscriptional repressor involved in regulation of meiosis andsilencing; contains WD repeats 0.012980.27334&radic&radic&radic S000005210YNL266WDubiousHypothetical protein 0.012710.26994&radic&radic&radic&radic&radic S000001604YKL121WUncharacterizedPutative protein of unknown function 0.012740.26994&radic S000002330GLT1YDL171CverifiedNAD(+)-dependent glutamate synthase (GOGAT), synthesizesglutamate from glutamine andalpha-ketoglutarate; with Gln1p, forms thesecondary pathway for glutamate biosynthesisfrom ammonia; expression regulated by nitrogensource 0.012810.26994 S000001129YHR087WVerifiedProtein involved in RNA metabolism, one of two yeast homologs (with Sdo1p/Ylr022cp) of the human protein SBDS responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome, also conserved in Archaea 0.012340.26492&radic&radic&radic&radic&radic&radic&radic S000004838MRPL44YMR225CverifiedMitochondrial ribosomal protein of the large subunit 0.012430.26492&radic&radic&radic&radic&radic S000004412URA4YLR420WverifiedDihydroorotase, catalyzes the third enzymatic step in the denovo biosynthesis of pyrimidines, convertingcarbamoyl-L-aspartate into dihydroorotate 0.012390.26492&radic&radic&radic&radic&radic&radic S000001359FYV10YIL097WverifiedProtein of unknown function, required for survival uponexposure to K1 killer toxin; involved inproteasome-dependent catabolite inactivation offructose-1,6-bisphosphatase; contains CTLHdomain 0.012340.26492&radic&radic&radic&radic&radic&radic S000001207DNA2YHR164CverifiedEssential tripartite DNA replication factor withsingle-stranded DNA-dependent ATPase,ATP-dependent nuclease, and helicaseactivities; required for Okazaki fragmentprocessing; involved in DNA repair pathways;potential Cdc28p substrate 0.01240.26492&radic&radic&radic&radic S000001730NTR2YKR022CverifiedEssential protein that forms a dimer with Ntr1p; also forms atrimer, with Ntr2p and the DExD/H-box RNAhelicase Prp43p, that is involved inspliceosome disassembly 0.012490.26492&radic&radic&radic&radic&radic&radic&radic&radic S000001734GCN3YKR026CverifiedAlpha subunit of the translation initiation factor eIF2B, theguanine-nucleotide exchange factor for eIF2;activity subsequently regulated byphosphorylated eIF2; first identified as apositive regulator of GCN4 expression 0.01210.26147&radic&radic&radic&radic&radic S000000123RPL19BYBL027WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl19Ap and has similarity to ratL19 ribosomal protein; rpl19a and rpl19b singlenull mutations result in slow growth, while thedouble null mutation is lethal 0.011940.26066&radic&radic&radic&radic&radic S000001885CDC4YFL009WverifiedF-box protein required for G1/S and G2/M transition, associateswith Skp1p and Cdc53p to form a complex,SCFCdc4, which acts as ubiquitin-protein ligasedirecting ubiquitination of the phosphorylatedCDK inhibitor Sic1p 0.011880.26042&radic S000005458YOL098CUncharacterizedPutative metalloprotease 0.011880.26042&radic S000002831CAD1YDR423CverifiedAP-1-like bZIP transcriptional activator involved in multiplestress responses, iron metabolism, andpleiotropic drug resistance; controls a set ofgenes involved in stabilizing proteins, bindsconsensus sequence TTACTAA; 5' UTR containsuORFs 0.011820.2592&radic&radic&radic&radic&radic&radic&radic S000000729GIM4YEL003WverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.011670.25771&radic&radic&radic&radic&radic&radic S000006383HDA3YPR179CverifiedSubunit of a possibly tetrameric trichostatin A-sensitive classII histone deacetylase complex that contains anHda1p homodimer and an Hda2p-Hda3p heterodimer;required for the activity of the complex; hassimilarity to Hda2p 0.011610.25625&radic&radic&radic&radic&radic&radic S000006259SEC8YPR055WverifiedEssential 121kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which has the essential function ofmediating polarized targeting of secretoryvesicles to active sites of exocytosis 0.011570.25625&radic&radic&radic S000001051YHR009CUncharacterizedPutative protein of unknown function; not an essential gene 0.011570.25625&radic&radic&radic&radic&radic S000002549PEX7YDR142CverifiedPeroxisomal signal receptor for the N-terminal nonapeptidesignal (PTS2) of peroxisomal matrix proteins;WD repeat protein; defects in human homologcause lethal rhizomelic chondrodysplasiapunctata (RCDP) 0.011620.25625 S000003085YGL117WUncharacterizedPutative protein of unknown function 0.011610.25625&radic&radic S000001594YKL111CDubiousDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene ABF1 0.011550.25615&radic&radic&radic&radic S000004837MRE11YMR224CverifiedSubunit of a complex with Rad50p and Xrs2p (RMX complex) thatfunctions in repair of DNA double-strand breaksand in telomere stability, exhibits nucleaseactivity that appears to be required for RMXfunction; widely conserved 0.011490.25513&radic&radic&radic&radic&radic&radic&radic S000001005OTU2YHL013CverifiedProtein of unknown function that may interact with ribosomes,based on co-purification experiments; member ofthe ovarian tumor-like (OTU) superfamily ofpredicted cysteine proteases; shows cytoplasmiclocalization 0.011380.25117&radic&radic&radic&radic&radic&radic&radic S000004829SKY1YMR216CverifiedSR protein kinase (SRPK) involved in regulating proteinsinvolved in mRNA metabolism and cationhomeostasis; similar to human SRPK1 0.011240.25117&radic&radic&radic&radic&radic S000000462SHG1YBR258CverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres &radic0.011180.25117&radic&radic&radic&radic&radic&radic S000001148TRR2YHR106WverifiedMitochondrial thioredoxin reductase involved in protectionagainst oxidative stress, required with Glr1pto maintain the redox state of Trx3p, containsactive-site motif (CAVC) present in prokaryoticthioredoxin reductases, binds NADPH and FAD 0.011230.25117&radic&radic S000000165AST1YBL069WverifiedPeripheral membrane protein that interacts with the plasmamembrane ATPase Pma1p and has a role in itstargeting to the plasma membrane, possibly byinfluencing its incorporation into lipid rafts 0.011260.25117&radic&radic&radic&radic&radic&radic&radic&radic S000000002VPS8YAL002WverifiedMembrane-associated hydrophilic protein that interacts with thesmall GTPase, Vps21p, to facilitate solublevacuolar protein localization; required forlocalization and trafficking of the CPY sortingreceptor; contains a RING finger motif 0.011060.24916&radic&radic&radic&radic&radic&radic S000005257YNL313CUncharacterizedProtein required for cell viability 0.011120.24916&radic&radic&radic&radic&radic&radic S000004186PWP1YLR196WverifiedProtein with WD-40 repeats involved in rRNA processing;associates with trans-acting ribosomebiogenesis factors; similar to beta-transducinsuperfamily 0.011110.24916&radic&radic&radic&radic S000005784HNT3YOR258WverifiedMember of the third branch of the histidine triad (HIT)superfamily of nucleotide-binding proteins;similar to Aprataxin, a Hint related proteinthat is mutated in individuals with ataxia withoculomotor apraxia 0.011040.24916&radic&radic&radic&radic&radic&radic S000002806UTP5YDR398WverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.010980.24793&radic&radic&radic S000003723SWE1YJL187CverifiedProtein kinase that regulates the G2/M transition by inhibitionof Cdc28p kinase activity; localizes to thenucleus and to the daughter side of themother-bud neck; homolog of S. pombe Wee1p;potential Cdc28p substrate 0.0110.24793&radic&radic S000000001TFC3YAL001CverifiedLargest of six subunits of the RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part of theTauB domain of TFIIIC that binds DNA at theBoxB promoter sites of tRNA and similar genes;cooperates with Tfc6p in DNA binding 0.010960.24793&radic&radic&radic&radic&radic&radic&radic S000005171JJJ1YNL227CverifiedProtein that contains a 70 amino acid J-domain, may function asa co-chaperone to recruit Hsp70-like activityto specific sites; mutation causes defects influid-phase endocytosis 0.010910.247&radic&radic&radic&radic&radic S000000792HPA3YEL066WverifiedD-Amino acid N-acetyltransferase, catalyzes N-acetylation ofD-amino acids through ordered bi-bi mechanismin which acetyl-CoA is first substrate boundand CoA is last product liberated; similar toHpa2p, acetylates histones weakly in vitro 0.010910.247&radic&radic&radic&radic S000005475PAP2YOL115WverifiedCatalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), anuclear poly (A) polymerase complex involved inRNA quality control; catalyzes polyadenylationof unmodified tRNAs, and snoRNA and rRNAprecursors; disputed role as a DNA polymerase 0.010870.24634&radic&radic&radic S000001188YHR145CDubiousHypothetical protein 0.010840.24634&radic S000005439YOL079WDubiousHypothetical protein 0.010850.24634&radic&radic&radic&radic&radic&radic S000006060UME1YPL139CverifiedNegative regulator of meiosis, required for repression of asubset of meiotic genes during vegetativegrowth, binding of histone deacetylase Rpd3prequired for activity, contains a NEE box and aWD repeat motif; homologous with Wtm1p, Wtm2p 0.010750.24542&radic&radic&radic&radic&radic S000002538YDR131CUncharacterizedF-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex 0.010740.24532&radic&radic&radic&radic S000004761YMR153C-ADubiousHypothetical protein 0.010720.24488&radic&radic&radic&radic&radic S000004376IKI3YLR384CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;maintains structural integrity of Elongator;homolog of human IKAP, mutations in which causefamilial dysautonomia (FD) 0.010610.24336&radic&radic&radic S000006376YPR172WUncharacterizedProtein of unknown function, transcriptionally activated by Yrm1p along with genes involved in multidrug resistance 0.010650.24336&radic&radic&radic&radic&radic&radic&radic&radic S000001128NAM8YHR086WverifiedRNA binding protein, component of the U1 snRNP protein; mutantsare defective in meiotic recombination and information of viable spores, involved in theformation of DSBs through meiosis-specificsplicing of MER2 pre-mRNA 0.010530.24139&radic&radic&radic&radic&radic S000001335SPO22YIL073CverifiedMeiosis-specific protein essential for chromosome synapsis,similar to phospholipase A2, involved incompletion of nuclear divisions during meiosis;induced early in meiosis 0.010490.24139&radic&radic&radic S000000119MCM2YBL023CverifiedProtein involved in DNA replication; component of the Mcm2-7hexameric complex that binds chromatin as apart of the pre-replicative complex 0.01060.24139&radic&radic&radic&radic&radic&radic&radic S000002783BCS1YDR375CverifiedProtein of the mitochondrial inner membrane that functions asan ATP-dependent chaperone, required for theassembly of the cytochrome bc(1) complex fromthe Rip1p and Qcr10p proteins; member of theCDC48/PAS1/SEC18 ATPase family 0.01040.23964&radic&radic&radic&radic S000004190YKE2YLR200WverifiedSubunit of the heterohexameric Gim/prefoldin protein complexinvolved in the folding of alpha-tubulin,beta-tubulin, and actin 0.010390.23964&radic&radic&radic&radic S000000935GLC7YER133WverifiedCatalytic subunit of type 1 serine/threonine proteinphosphatase, involved in many processesincluding glycogen metabolism, sporulation, andmitosis; interacts with multiple regulatorysubunits; predominantly isolated with Sds22p 0.010380.23964&radic&radic&radic&radic S000004421CRN1YLR429WverifiedCoronin, cortical actin cytoskeletal component that associateswith the Arp2p/Arp3p complex to regulate itsactivity 0.01040.23964&radic S000004255NEJ1YLR265CverifiedProtein involved in regulation of nonhomologous end joining;repressed by MAT heterozygosity; associateswith Lif1p and regulates its cellulardistribution 0.010420.23964&radic&radic&radic&radic&radic&radic S000001599PRR1YKL116CverifiedProtein kinase with a possible role in MAP kinase signaling inthe pheromone response pathway 0.010340.23916&radic&radic&radic&radic&radic&radic S000003304UPF3YGR072WverifiedComponent of the nonsense-mediated mRNA decay (NMD) pathway,along with Nam7p and Nmd2p; involved in decayof mRNA containing nonsense codons; involved intelomere maintenance 0.010290.23875&radic&radic&radic&radic&radic&radic S000000884UTP7YER082CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.010280.23807&radic&radic&radic&radic&radic&radic S000003934SOF1YLL011WverifiedEssential subunit of the U3 (box C+D) snRNP complex requiredfor 2' O-methylation of pre-RNA; has similarityto the beta subunit of trimeric G-proteins andthe splicing factor Prp4p 0.010250.23807&radic&radic&radic&radic&radic S000003457AMA1YGR225WverifiedActivator of meiotic anaphase promoting complex (APC/C); Cdc20pfamily member; required for initiation of sporewall assembly; required for Clb1p degradationduring meiosis 0.010250.23807&radic&radic&radic&radic S000004070EMP46YLR080WverifiedIntegral membrane component of endoplasmic reticulum-derivedCOPII-coated vesicles, which function in ER toGolgi transport 0.010230.23692&radic&radic&radic&radic S000004871YMR258CUncharacterizedProtein of unknown function with similarity to F-box proteins; physically interacts with Skp1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR258C is not an essential gene 0.01020.23692&radic&radic&radic&radic&radic&radic&radic S000003783LSM8YJR022WverifiedLsm (Like Sm) protein; forms heteroheptameric complex (withLsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p)that is part of spliceosomal U6 snRNP and isalso implicated in processing of pre-tRNA,pre-snoRNA, and pre-rRNA 0.010210.23692&radic&radic&radic&radic&radic S000002835RPN9YDR427WverifiedNon-ATPase regulatory subunit of the 26S proteasome, hassimilarity to putative proteasomal subunits inother species; null mutant is temperaturesensitive and exhibits cell cycle andproteasome assembly defects 0.010150.23472&radic&radic&radic S000003084CDC20YGL116WverifiedCell-cycle regulated activator of anaphase-promotingcomplex/cyclosome (APC/C), which is requiredfor metaphase/anaphase transition; directsubiquitination of mitotic cyclins, Pds1p, andother anaphase inhibitors; potential Cdc28psubstrate 0.010070.23472&radic&radic&radic&radic S000004570CAC2YML102WverifiedComponent of the chromatin assembly complex (with Rlf2p andMsi1p) that assembles newly synthesizedhistones onto recently replicated DNA, requiredfor building functional kinetochores, conservedfrom yeast to humans 0.009950.23286&radic S000003181SKI8YGL213CverifiedProtein involved in exosome mediated 3' to 5' mRNA degradationand translation inhibition of non-poly(A) mRNAsas well as double-strand break formation duringmeiotic recombination; required for repressingpropagation of dsRNA viruses 0.009930.23286&radic&radic&radic&radic&radic&radic S000000450YBR246WUncharacterizedHypothetical protein 0.009910.23225&radic&radic&radic&radic&radic&radic S000003335NOP7YGR103WverifiedNucleolar protein involved in rRNA processing and 60S ribosomalsubunit biogenesis; constituent of severaldifferent pre-ribosomal particles; required forexit from G0 and the initiation ofcell proliferation 0.009840.23051&radic&radic&radic&radic S000003778ESS1YJR017CverifiedPeptidylprolyl-cis/trans-isomerase (PPIase) specific forphosphorylated serine and threonine residuesN-terminal to proline; regulatesphosphorylation of the RNA polymerase II largesubunit (Rpo21p) C-terminal domain 0.009820.23051&radic&radic&radic&radic&radic S000004272YLR282CDubiousHypothetical protein 0.009790.23051&radic&radic&radic&radic&radic&radic S000001297CKA1YIL035CverifiedAlpha catalytic subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA2, CKB1 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.009850.23051&radic&radic&radic&radic&radic S000006314RPC40YPR110CverifiedRNA polymerase subunit, common to RNA polymerase I and III 0.009760.22804&radic&radic&radic&radic S000000252RPS11BYBR048WverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps11Ap and has similarity to E.coli S17 and rat S11 ribosomal proteins 0.009670.22804&radic&radic&radic&radic S000004280GUF1YLR289WverifiedMitochondrial GTPase of unknown function, similar to E. colielongation factor-type GTP-binding protein LepAand to LK1236.1 from Caenorhabditis elegans 0.009770.22804&radic&radic&radic&radic S000002834YDR426CDubiousHypothetical protein 0.00970.22804&radic&radic&radic&radic&radic S000000229YBR025CUncharacterizedHypothetical protein 0.009730.22804&radic&radic&radic&radic S000003272KSS1YGR040WverifiedMitogen-activated protein kinase (MAPK) involved in signaltransduction pathways that control filamentousgrowth and pheromone response 0.009730.22804&radic&radic&radic&radic&radic S000001070DAP2YHR028CverifiedDipeptidyl aminopeptidase, synthesized as a glycosylatedprecursor; localizes to the vacuolar membrane;similar to Ste13p 0.009610.22698&radic&radic&radic&radic&radic S000003491YGR259CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W 0.009580.22698&radic&radic&radic&radic S000004262YCS4YLR272CverifiedNon-SMC subunit of the condensin complex(Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required forestablishment and maintenance of chromosomecondensation, chromosome segregation, chromatinbinding of condensin and silencing at themating type locus 0.00960.22698&radic&radic&radic&radic&radic&radic S000000122LSM2YBL026WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.009510.22571&radic&radic&radic&radic S000004410CDC73YLR418CverifiedConstituent of Paf1 complex with RNA polymerase II, Paf1p,Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinctfrom Srb-containing Pol II complexes; requiredfor expression of certain genes, modificationof some histones, and telomere maintenance 0.009520.22571&radic&radic&radic&radic&radic&radic S000000449ISW1YBR245CverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPase thatforms a complex with Ioc2p and Ioc4p toregulate transcription elongation, and acomplex with Ioc3p to repress transcriptioninitiation 0.009520.22571&radic&radic&radic&radic&radic S000002505GRX3YDR098CverifiedHydroperoxide and superoxide-radical responsiveglutathione-dependent oxidoreductase; monothiolglutaredoxin subfamily member along with Grx4pand Grx5p; protects cells from oxidative damage 0.009490.22372&radic&radic&radic&radic&radic&radic S000000851TPA1YER049WuncharacterizedProtein of unknown function; interacts with Sup45p (eRF1),Sup35p (eRF3) and Pab1p; has a role intranslation termination efficiency, mRNApoly(A) tail length and mRNA stability 0.009380.22372&radic&radic&radic S000006373JIP5YPR169WuncharacterizedNucleolar protein of unknown function, exhibits a physicalinteraction with Bre1p 0.009480.22372&radic&radic&radic S000003162HOS2YGL194CverifiedHistone deacetylase required for gene activation via specificdeacetylation of lysines in H3 and H4 histonetails; subunit of the Set3 complex, ameiotic-specific repressor of sporulationspecific genes that contains deacetylaseactivity 0.009460.22372&radic&radic&radic&radic&radic&radic S000004760YIM1YMR152WverifiedProtein of unknown function; null mutant displays sensitivityto DNA damaging agents; the authentic,non-tagged protein is detected in highlypurified mitochondria in high-throughputstudies 0.009420.22372&radic&radic&radic&radic&radic S000001906UBP6YFR010WverifiedUbiquitin-specific protease situated in the base subcomplex ofthe 26S proteasome, releases free ubiquitinfrom branched polyubiquitin chains; deletioncauses hypersensitivity to cycloheximide andother toxic compounds 0.009370.22366&radic&radic&radic&radic&radic S000005006GCD10YNL062CverifiedSubunit of tRNA (1-methyladenosine) methyltransferase withGcd14p, required for the modification of theadenine at position 58 in tRNAs, especiallytRNAi-Met; first identified as a negativeregulator of GCN4 expression &radic0.009350.22287&radic&radic S000004749YMR141CDubiousHypothetical protein 0.009320.22287&radic&radic&radic&radic S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.009310.2228&radic&radic&radic&radic&radic S000000846ERG28YER044CverifiedEndoplasmic reticulum membrane protein, may facilitateprotein-protein interactions between the Erg26pdehydrogenase and the Erg27p 3-ketoreductaseand/or tether these enzymes to the ER, alsointeracts with Erg6p 0.00930.22059&radic&radic&radic&radic&radic S000001312PCL7YIL050WverifiedPho85p cyclin of the Pho80p subfamily, forms a functionalkinase complex with Pho85p which phosphorylatesMmr1p and is regulated by Pho81p; involved inglycogen metabolism, expression is cell-cycleregulated 0.009190.22059&radic&radic&radic&radic S000000147PIN4YBL051CverifiedProtein involved in G2/M phase progression and response to DNAdamage, interacts with Rad53p; contains an RNArecognition motif, a nuclear localizationsignal, and several SQ/TQ cluster domains;hyperphosphorylated in response to DNA damage 0.009170.22043&radic&radic&radic&radic S000004294MET17YLR303WverifiedO-acetyl homoserine-O-acetyl serine sulfhydrylase, required forsulfur amino acid synthesis 0.009160.2201&radic&radic&radic&radic S000003306SMD1YGR074WverifiedCore Sm protein Sm D1; part of heteroheptameric complex (withSmb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D1 0.009150.21959&radic&radic&radic&radic S000000406CDC47YBR202WverifiedComponent of the hexameric MCM complex, which is important forpriming origins of DNA replication in G1 andbecomes an active ATP-dependent helicase thatpromotes DNA melting and elongation whenactivated by Cdc7p-Dbf4p in S-phase 0.009080.21791&radic&radic&radic&radic&radic&radic&radic&radic S000005606DIA2YOR080WverifiedOrigin-binding F-box protein that forms an SCF ubiquitin ligasecomplex with Skp1p and Cdc53p; plays a role inDNA replication, involved in invasive andpseudohyphal growth 0.009090.21791&radic&radic&radic&radic&radic S000002910SAM2YDR502CverifiedS-adenosylmethionine synthetase, catalyzes transfer of theadenosyl group of ATP to the sulfur atom ofmethionine; one of two differentially regulatedisozymes (Sam1p and Sam2p) 0.009040.2179&radic&radic S000002743MSN5YDR335WverifiedKaryopherin involved in nuclear import and export; shown to beresponsible for nuclear import of replicationprotein A and for export of several proteinsincluding Swi6p, Far1p, and Pho4p; cargodissociation involves binding to RanGTP 0.008990.21633&radic&radic&radic&radic S000005798YTM1YOR272WverifiedConstituent of 66S pre-ribosomal particles, required formaturation of the large ribosomal subunit 0.009030.21633&radic S000004652ERB1YMR049CverifiedProtein required for maturation of the 25S and 5.8S ribosomalRNAs; constituent of 66S pre-ribosomalparticles; homologous to mammalian Bop1 0.008990.21633&radic S000006160YAR1YPL239WverifiedCytoplasmic ankyrin-repeat containing protein of unknownfunction, proposed to link the processes of 40Sribosomal subunit biogenesis and adaptation toosmotic and oxidative stress; expressionrepressed by heat shock 0.0090.21633&radic&radic&radic&radic S000002435REG1YDR028CverifiedRegulatory subunit of type 1 protein phosphatase Glc7p,involved in negative regulation ofglucose-repressible genes 0.008910.21434&radic&radic&radic&radic S000006099CBC2YPL178WverifiedSmall subunit of the heterodimeric cap binding complex thatalso contains Sto1p, component of thespliceosomal commitment complex; interacts withNpl3p, possibly to package mRNA for export fromthe nucleus; contains an RNA-binding motif 0.008880.21434&radic&radic&radic&radic&radic S000000667IMG2YCR071CverifiedMitochondrial ribosomal protein of the small subunit 0.008870.21434&radic&radic S000000013NTG1YAL015CverifiedDNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involvedin base excision repair, localizes to thenucleus and mitochondrion 0.008840.21371&radic&radic&radic&radic&radic&radic S000003193VRG4YGL225WverifiedGolgi GDP-mannose transporter; regulates Golgi function andglycosylation in Golgi 0.00880.2129&radic&radic S000000302MMS4YBR098WverifiedSubunit of the structure-specific Mms4p-Mus81p endonucleasethat cleaves branched DNA; involved inrecombination and DNA repair 0.008810.2129&radic&radic&radic&radic&radic S000001744CAF4YKR036CverifiedWD40 repeat-containing protein associated with the CCR4-NOTcomplex, interacts in a Ccr4p-dependent mannerwith Ssn2p; also interacts with Fis1p, Mdv1pand Dnm1p and plays a role in mitochondrialfission 0.008740.21024&radic&radic&radic S000002601YDR193WDubiousHypothetical protein 0.008730.21024&radic&radic&radic&radic&radic S000003086YGL118CDubiousHypothetical protein 0.008770.21024&radic&radic S000004300IMH1YLR309CverifiedProtein involved in vesicular transport, mediates transportbetween an endosomal compartment and the Golgi,contains a Golgi-localization (GRIP) domainthat interacts with activated Arl1p-GTP tolocalize Imh1p to the Golgi 0.008720.21024&radic&radic&radic&radic&radic S000002612COQ4YDR204WverifiedProtein with a role in ubiquinone (Coenzyme Q) biosynthesis,possibly functioning in stabilization of Coq7p;located on the matrix face of the mitochondrialinner membrane; component of a mitochondrialubiquinone-synthesizing complex 0.008720.21024&radic&radic&radic&radic&radic S000003623TRL1YJL087CverifiedtRNA ligase, required for tRNA splicing; composed of threeessential domains containing thephosphodiesterase, polynucleotide kinase, andligase activities required for ligation;localized at the inner membrane of the nuclearenvelope 0.008750.21024&radic&radic&radic S000005263YNL319WDubiousDubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14 0.008640.20976&radic&radic&radic&radic&radic S000002321YDL162CDubiousHypothetical protein 0.008640.20976&radic&radic S000003751YJL215CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data 0.008630.20976&radic&radic&radic&radic&radic S000000653PWP2YCR057CverifiedConserved 90S pre-ribosomal component essential for properendonucleolytic cleavage of the 35 S rRNAprecursor at A0, A1, and A2 sites; containseight WD-repeats; PWP2 deletion leads todefects in cell cycle and bud morphogenesis 0.008640.20976&radic S000003455HSV2YGR223CverifiedPhosphatidylinositol 3,5-bisphosphate-binding protein,predicted to fold as a seven-bladedbeta-propeller; displays punctate cytoplasmiclocalization 0.008590.20873&radic&radic&radic S000001493UFD4YKL010CverifiedUbiquitin-protein ligase (E3) that interacts with Rpt4p andRpt6p, two subunits of the 19S particle of the26S proteasome; cytoplasmic E3 involved in thedegradation of ubiquitin fusion proteins 0.008580.20873&radic&radic&radic&radic&radic&radic&radic S000000149YBL053WDubiousHypothetical protein 0.008530.20827&radic&radic&radic S000001028MUP3YHL036WverifiedLow affinity methionine permease, similar to Mup1p 0.008480.20686&radic&radic&radic&radic S000003859YJR098CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; detectable in highly purified mitochondria 0.008490.20686&radic&radic&radic S000003323PRP31YGR091WverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.008480.20686&radic&radic&radic&radic S000005295URK1YNR012WverifiedUridine/cytidine kinase, component of the pyrimidineribonucleotide salvage pathway that convertsuridine into UMP and cytidine into CMP;involved in the pyrimidine deoxyribonucleotidesalvage pathway, converting deoxycytidine intodCMP 0.008450.20662&radic&radic&radic&radic S000001153UBA4YHR111WverifiedProtein that activates Urm1p before its conjugation to proteins(urmylation); one target is the thioredoxinperoxidase Ahp1p, suggesting a role ofurmylation in the oxidative stress response 0.008430.20607&radic&radic&radic&radic S000002269RRP42YDL111CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp4p, Rrp41p,Rrp43p and Dis3p 0.00840.20493&radic&radic&radic&radic&radic S000003295SPT4YGR063CverifiedProtein that forms a complex with Spt5p and mediates bothactivation and inhibition of transcriptionelongation, and plays a role in pre-mRNAprocessing; in addition, Spt4p is involved inkinetochore function and gene silencing 0.008410.20493&radic&radic S000000794YEL068CDubiousHypothetical protein 0.008380.20493&radic&radic S000001566YKL083WDubiousDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14 0.008320.20466&radic&radic&radic S000006132NIP7YPL211WverifiedNucleolar protein required for 60S ribosome subunit biogenesis,constituent of 66S pre-ribosomal particles;physically interacts with Nop8p and the exosomesubunit Rrp43p 0.008290.20449&radic&radic&radic S000002597SLY1YDR189WverifiedHydrophilic protein involved in vesicle trafficking between theER and Golgi; SM (Sec1/Munc-18) family proteinthat binds the tSNARE Sed5p and stimulates itsassembly into a trans-SNARE membrane-proteincomplex 0.008290.20441&radic&radic&radic&radic&radic S000006161HSP82YPL240CverifiedCytoplasmic chaperone (Hsp90 family) required for pheromonesignaling and negative regulation of Hsf1p;docks with the mitochondrial import receptorTom70p for preprotein delivery; interacts withco-chaperones Cns1p, Cpr6p, Cpr7p, and Sti1p 0.008240.20284&radic&radic&radic S000000187MAP2YBL091CverifiedMethionine aminopeptidase, catalyzes the cotranslationalremoval of N-terminal methionine from nascentpolypeptides; function is partially redundantwith that of Map1p 0.008250.20284&radic&radic&radic&radic&radic&radic S000000456DUT1YBR252WverifieddUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, therebypreventing incorporation of uracil into DNAduring replication; critical for themaintenance of genetic stability 0.008260.20284&radic&radic&radic&radic&radic&radic S000002810DIT2YDR402CverifiedN-formyltyrosine oxidase, sporulation-specific microsomalenzyme required for spore wall maturation,involved in the production of a solubleLL-dityrosine-containing precursor of the sporewall, homologous to cytochrome P-450s 0.008240.20284&radic&radic&radic&radic S000001937ERJ5YFR041CuncharacterizedType I membrane protein with a J domain is required to preservethe folding capacity of the endoplasmicreticulum; loss of the non-essential ERJ5 geneleads to a constitutively induced unfoldedprotein response 0.008270.20284&radic&radic&radic&radic S000002273IWR1YDL115CuncharacterizedProtein of unknown function, deletion causes hypersensitivityto the K1 killer toxin 0.008220.20284&radic&radic&radic S000006347RRP15YPR143WverifiedNucleolar protein, constituent of pre-60S ribosomal particles;required for processing of the 27S pre-rRNA atthe A2 site to yield 5.8S and 25S rRNA 0.008220.20284&radic&radic&radic&radic S000001737SET3YKR029CverifiedDefining member of the SET3 histone deacetylase complex whichis a meiosis-specific repressor of sporulationgenes; necessary for efficient transcription byRNAPII; one of two yeast proteins that containsboth SET and PHD domains 0.008220.20284&radic&radic S000004161YLR171WDubiousHypothetical protein 0.008250.20284&radic&radic&radic&radic&radic S000001108SSF1YHR066WverifiedConstituent of 66S pre-ribosomal particles, required forribosomal large subunit maturation;functionally redundant with Ssf2p; member ofthe Brix family 0.008180.20226&radic&radic&radic&radic S000004868GFD1YMR255WverifiedCoiled-coiled protein of unknown function, identified as ahigh-copy suppressor of a dbp5 mutation 0.008180.20192&radic&radic&radic&radic&radic&radic S000001341AIR1YIL079CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p to regulate methylationof Npl3p, which modulates Npl3p function inmRNA processing and export; has similarity toAir2p 0.00810.20061&radic&radic&radic&radic&radic S000003201TAN1YGL232WverifiedPutative tRNA acetyltransferase, RNA-binding protein requiredfor the formation of the modified nucleosideN(4)-acetylcytidine in serine and leucine tRNAsbut not required for the same modification in18S rRNA 0.008150.20061&radic&radic&radic&radic&radic&radic&radic S000002732UTP4YDR324CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.008150.20061&radic&radic&radic S000001220YHR177WUncharacterized 0.008040.19915&radic&radic&radic&radic&radic S000001782YKR074WUncharacterizedPutative protein of unknown function; epitope-tagged protein localizes to the cytoplasm 0.008040.19915&radic&radic&radic&radic&radic&radic&radic S000004901HSH155YMR288WverifiedU2-snRNP associated splicing factor that forms extensiveassociations with the branch site-3' splicesite-3' exon region upon prespliceosomeformation; similarity to the mammalian U2snRNP-associated splicing factor SAP155 0.008040.19915&radic&radic&radic&radic&radic S000002460YDR053WDubiousPutative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex 0.007950.19862&radic&radic&radic&radic&radic S000001146GRE3YHR104WverifiedAldose reductase involved in methylglyoxal, d-xylose andarabinose metabolism; stress induced (osmotic,ionic, oxidative, heat shock, starvation andheavy metals); regulated by the HOG pathway 0.007970.19862&radic&radic&radic&radic&radic&radic S000001501SWD2YKL018WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lys 4 and is involved intelomeric silencing; subunit of CPF (cleavageand polyadenylation factor), a complex involvedin RNAP II transcription termination &radic0.007980.19862&radic&radic&radic&radic S000004625MSS1YMR023CverifiedMitochondrial protein, forms a heterodimer complex with Mto1pthat performs the 5-carboxymethylaminomethylmodification of the wobble uridine base inmitochondrial tRNAs; similar to human GTPBP3 0.007950.19862&radic&radic&radic&radic S000000886YER084WDubiousHypothetical protein 0.007920.198&radic&radic&radic&radic&radic S000002572TRM82YDR165WverifiedSubunit of a tRNA methyltransferase complex composed of Trm8pand Trm82p that catalyzes 7-methylguanosinemodification of tRNA &radic0.007910.1972&radic&radic&radic&radic&radic S000006405ARR3YPR201WverifiedArsenite transporter of the plasma membrane, required forresistance to arsenic compounds; transcriptionis activated by Arr1p in the presence ofarsenite 0.007890.1972&radic&radic&radic S000002490RRP8YDR083WverifiedNucleolar protein involved in rRNA processing, pre-rRNAcleavage at site A2; also involved in telomeremaintenance; mutation is synthetically lethalwith a gar1 mutation 0.007880.1972&radic&radic&radic&radic&radic&radic S000002653MNN10YDR245WverifiedSubunit of a Golgi mannosyltransferase complex also containingAnp1p, Mnn9p, Mnn11p, and Hoc1p that mediateselongation of the polysaccharide mannanbackbone; membrane protein of themannosyltransferase family 0.007870.1972&radic&radic&radic S000002744YDR336WUncharacterizedPutative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene 0.007870.1972&radic&radic&radic&radic S000004558UTP14YML093WverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.007860.197&radic&radic&radic S000006047NAN1YPL126WverifiedU3 snoRNP protein, component of the small (ribosomal) subunit(SSU) processosome containing U3 snoRNA;required for the biogenesis of18S rRNA 0.007810.19606&radic&radic&radic&radic S000001334HOP1YIL072WverifiedMeiosis-specific DNA binding protein that displays Red1pdependent localization to the unsynapsedaxial-lateral elements of the synaptonemalcomplex; required for homologous chromosomesynapsis and chiasma formation 0.007830.19606&radic&radic&radic&radic S000002814PDR15YDR406WverifiedATP binding cassette (ABC) transporter of the plasma membrane;general stress response factor implicated incellular detoxification; target of Pdr1p, Pdr3pand Pdr8p transcription regulators; promotercontains a PDR responsive element 0.007720.19466&radic&radic&radic&radic&radic S000000740YEL014CDubiousHypothetical protein 0.007750.19466&radic&radic&radic&radic&radic&radic S000003767SUI2YJR007WverifiedAlpha subunit of the translation initiation factor eIF2,involved in the identification of the startcodon; phosphorylation of Ser51 is required forregulation of translation by inhibiting theexchange of GDP for GTP 0.007730.19466&radic&radic&radic S000000738UBC8YEL012WverifiedUbiquitin-conjugating enzyme that negatively regulatesgluconeogenesis by mediating theglucose-induced ubiquitination offructose-1,6-bisphosphatase (FBPase);cytoplasmic enzyme that catalyzes theubiquitination of histones in vitro 0.007730.19466&radic&radic&radic&radic S000001006YLF2YHL014CverifiedProtein of unknown function, has weak similarity to E. coliGTP-binding protein gtp1; the authentic,non-tagged protein is detected in highlypurified mitochondria in high-throughputstudies 0.007670.1942&radic&radic&radic&radic S000004416SPP382YLR424WverifiedEssential protein that forms a dimer with Ntr2p; also forms atrimer, with Ntr2p and Prp43p, that is involvedin spliceosome disassembly; found also in amultisubunit complex with the splicing factorClf1p; suppressor of prp38-1 mutation 0.007640.19335&radic&radic&radic&radic S000006345KAR3YPR141CverifiedMinus-end-directed microtubule motor that functions in mitosisand meiosis, localizes to the spindle pole bodyand localization is dependent on functionalCik1p, required for nuclear fusion duringmating; potential Cdc28p substrate 0.007630.19335&radic&radic&radic&radic&radic&radic S000005895RAD17YOR368WverifiedCheckpoint protein, involved in the activation of the DNAdamage and meiotic pachytene checkpoints; withMec3p and Ddc1p, forms a clamp that is loadedonto partial duplex DNA; homolog of human andS. pombe Rad1 and U. maydis Rec1 proteins 0.007620.19301&radic&radic&radic&radic&radic&radic S000004783HOT1YMR172WverifiedTranscription factor required for the transient induction ofglycerol biosynthetic genes GPD1 and GPP2 inresponse to high osmolarity; targets Hog1p toosmostress responsive promoters; has similarityto Msn1p and Gcr1p 0.007610.19301&radic&radic&radic S000000958YER156CUncharacterizedHypothetical protein 0.007610.19301&radic&radic&radic&radic S000004846YMR233WUncharacterizedProtein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; YMR233W is not an essential gene 0.007620.19301&radic&radic&radic&radic&radic&radic&radic S000000112FUS3YBL016WverifiedMitogen-activated protein kinase involved in mating pheromoneresponse; activated by phosphorylation bySte7p; provides specificity during the matingvs. filamentous growth response byphosphorylating transcriptional and cytoplasmictargets 0.007580.19253&radic&radic&radic&radic&radic&radic S000002198NAT1YDL040CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.007570.19151&radic&radic&radic S000003993YLR003CUncharacterizedPutative protein of unknown function that may participate in DNA replication; green fluorescent protein (GFP)-fusion protein is localized to the nucleus; YLR003C is not an essential gene 0.007530.19151&radic&radic&radic&radic S000004159YLR169WDubiousHypothetical protein 0.007530.19151&radic&radic&radic&radic S000004887RCE1YMR274CverifiedType II CAAX prenyl protease involved in the proteolysis andmaturation of Ras and the a-factor matingpheromone 0.007560.19151&radic&radic&radic&radic S000001365DPH1YIL103WverifiedProtein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p,for synthesis of diphthamide, which is amodified histidine residue of translationelongation factor 2 (Eft1p or Eft2p); may actin a complex with Dph2p and Kti11p 0.007510.19111&radic&radic&radic S000000200YBL104CUncharacterizedHypothetical protein 0.007530.19111&radic&radic S000001185RPC10YHR143W-AverifiedRNA polymerase subunit, found in RNA polymerase complexes I,II, and III 0.007490.19052&radic&radic&radic&radic S000002251PMT5YDL093WverifiedProtein O-mannosyltransferase, transfers mannose residues fromdolichyl phosphate-D-mannose to proteinserine/threonine residues; acts in a complexwith Pmt3p, can instead interact with Pmt2p insome conditions; target for new antifungals 0.007480.19052&radic&radic S000002470YDR063WUncharacterizedHypothetical protein 0.00740.18924&radic&radic&radic&radic&radic&radic S000001492MRT4YKL009WverifiedProtein involved in mRNA turnover and ribosome assembly,localizes to the nucleolus 0.00740.18924&radic&radic&radic&radic&radic S000004758IMP1YMR150CverifiedCatalytic subunit of the mitochondrial inner membrane peptidasecomplex, required for maturation ofmitochondrial proteins of the intermembranespace; complex contains Imp1p and Imp2p (bothcatalytic subunits), and Som1p 0.007380.18883&radic&radic&radic&radic&radic S000000459YBR255WUncharacterizedProtein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.007330.18791&radic&radic&radic S000002740IRC3YDR332WuncharacterizedHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 0.007360.18791&radic&radic&radic&radic&radic S000002625RAD9YDR217CverifiedDNA damage-dependent checkpoint protein, required forcell-cycle arrest in G1/S, intra-S, and G2/M;transmits checkpoint signal by activatingRad53p and Chk1p; hyperphosphorylated by Mec1pand Tel1p; potential Cdc28p substrate 0.007310.18734&radic&radic&radic&radic&radic&radic&radic S000001305CBR1YIL043CverifiedMicrosomal cytochrome b reductase, not essential for viability;also detected in mitochondria; mutation inconserved NADH binding domain of the humanortholog results in type I methemoglobinemia 0.007310.18734&radic&radic&radic&radic&radic S000002537FIN1YDR130CverifiedSpindle pole body-related intermediate filament protein, formscell cycle-specific filaments between spindlepole bodies in mother and daughter cells, ableto self-assemble, expression induced duringS/G2, localization cell-cycle dependent 0.007310.18734&radic&radic&radic&radic&radic&radic S000003200YGL231CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum 0.007310.18734&radic&radic&radic S000000773YEL047CVerifiedFumurate ReDuctase Soluble 0.007230.18582&radic&radic&radic&radic S000001917ATG18YFR021WverifiedPhosphatidylinositol 3,5-bisphosphate-binding protein of thevacuolar membrane, predicted to fold as aseven-bladed beta-propeller; required forrecycling of Atg9p through thepre-autophagosomal structure 0.007220.18582&radic S000003399CLC1YGR167WverifiedClathrin light chain, subunit of the major coat proteininvolved in intracellular protein transport andendocytosis; thought to regulate clathrinfunction, two Clathrin heavy chains (CHC1) formthe clathrin triskelion structural component 0.007190.18524&radic&radic&radic&radic S000000070ADE1YAR015WverifiedN-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR)synthetase, required for 'de novo' purinenucleotide biosynthesis; red pigmentaccumulates in mutant cells deprived of adenine 0.00720.18524&radic&radic&radic&radic&radic&radic&radic S000005202DSL1YNL258CverifiedEndoplasmic reticulum (ER)-localized peripheral membraneprotein required for Golgi-to-ER retrogradetraffic; component of the ER target site thatinteracts with coatomer, the major component ofthe COPI vesicle protein coat 0.007180.18431&radic&radic&radic&radic S000000420YBP1YBR216CverifiedProtein required for oxidation of specific cysteine residues ofthe transcription factor Yap1p, resulting inthe nuclear localization of Yap1p in responseto stress 0.007150.18431&radic&radic&radic&radic&radic S000003188YGL220WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus 0.007180.18431&radic&radic&radic&radic&radic&radic S000004427TSR2YLR435WverifiedProtein with a potential role in pre-rRNA processing 0.007180.18431&radic&radic&radic S000000111ACH1YBL015WverifiedAcetyl-coA hydrolase, primarily localized to mitochondria;required for acetate utilization and fordiploid pseudohyphal growth 0.007150.18431&radic&radic&radic&radic&radic S000006384AOS1YPR180WverifiedNuclear protein that acts as a heterodimer with Uba2p toactivate Smt3p (SUMO) before its conjugation toproteins (sumoylation), which may play a rolein protein targeting; essential for viability 0.007120.18319&radic&radic&radic&radic&radic&radic&radic S000002603REF2YDR195WverifiedRNA-binding protein involved in the cleavage step of mRNA3'-end formation prior to polyadenylation, andin snoRNA maturation; part of holo-CPFsubcomplex APT, which associates with 3'-endsof snoRNA- and mRNA-encoding genes 0.007060.18264&radic&radic&radic&radic&radic S000002691GCN2YDR283CverifiedProtein kinase, phosphorylates the alpha-subunit of translationinitiation factor eIF2 (Sui2p) in response tostarvation; activated by uncharged tRNAs andthe Gcn1p-Gcn20p complex 0.007060.18264&radic&radic&radic&radic&radic S000001366SHQ1YIL104CverifiedEssential nuclear protein, required for accumulation of boxH/ACA snoRNAs and for rRNA processing;interacts with Naf1p 0.007040.18225&radic&radic&radic S000000682CSM1YCR086WverifiedNucleolar protein that forms a complex with Lrs4p which bindsMam1p at kinetochores during meiosis I tomediate accurate chromosome segregation, may beinvolved in premeiotic DNA replication;possible role in telomere maintenance 0.007040.18225&radic&radic S000003661GCD14YJL125CverifiedSubunit of tRNA (1-methyladenosine) methyltransferase, withGcd10p, required for the modification of theadenine at position 58 in tRNAs, especiallytRNAi-Met; first identified as a negativeregulator of GCN4 expression &radic0.007030.18225&radic&radic&radic S000002546RUB1YDR139CverifiedUbiquitin-like protein with similarity to mammalian NEDD8;conjugation (neddylation) substrates includethe cullins Cdc53p, Rtt101p, and Cul3p;activated by Ula1p and Uba3p (E1 enzyme pair);conjugation mediated by Ubc12p (E2 enzyme) 0.007030.18177&radic&radic&radic&radic&radic&radic&radic S000002203FAD1YDL045CverifiedFlavin adenine dinucleotide (FAD) synthetase, performs thesecond step in synthesis of FAD from riboflavin 0.007010.18016&radic&radic&radic&radic S000002881PRP3YDR473CverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.006960.18016&radic&radic S000001859MOB2YFL034C-BverifiedComponent of the RAM signaling network, localizes and activatesthe Ace2p in the daughter cell nucleus todirect daughter cell-specific transcription ofseveral genes involved in cell separation;Mob1p-like protein 0.006930.18016&radic&radic&radic&radic&radic&radic S000003207CSE1YGL238WverifiedNuclear envelope protein that mediates the nuclear export ofimportin alpha (Srp1p), homolog of metazoan CASprotein, required for accurate chromosomesegregation 0.006980.18016&radic&radic&radic&radic&radic&radic&radic S000005450MSH2YOL090WverifiedProtein that forms heterodimers with Msh3p and Msh6p that bindto DNA mismatches to initiate the mismatchrepair process; contains a Walker ATP-bindingmotif required for repair activity; Msh2p-Msh6pbinds to and hydrolyzes ATP 0.006960.18016&radic&radic&radic&radic S000002580ARG82YDR173CverifiedInositol polyphosphate multikinase (IPMK), sequentiallyphosphorylates Ins(1,4,5)P3 to formIns(1,3,4,5,6)P5; putative nuclear lipidinositol PI3-kinase; regulates arginine-,phosphate-, and nitrogen-responsive genes 0.0070.18016&radic&radic&radic&radic&radic&radic S000001259IMD2YHR216WverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, expression is induced bymycophenolic acid resulting in resistance tothe drug, expression is repressed by nutrientlimitation 0.006960.18016&radic&radic&radic S000005290ATG3YNR007CverifiedProtein involved in autophagy; E2-like enzyme that plays a rolein formation of Atg8p-phosphatidylethanolamineconjugates, which are involved in membranedynamics during autophagy 0.006940.18016&radic&radic&radic&radic S000000831SMB1YER029CverifiedCore Sm protein Sm B; part of heteroheptameric complex (withSmd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm B and Sm B' 0.0070.18016&radic&radic&radic S000001897LOC1YFR001WverifiedNuclear protein involved in asymmetric localization of ASH1mRNA; binds double-stranded RNA in vitro;constituent of 66S pre-ribosomal particles 0.006970.18016&radic&radic&radic&radic&radic S000003853FIP1YJR093CverifiedSubunit of cleavage polyadenylation factor (CPF), interactsdirectly with poly(A) polymerase (Pap1p) toregulate its activity 0.0070.18016&radic&radic S000004852RNT1YMR239CverifiedRNAase III; cleaves a stem-loop structure at the 3' end of U2snRNA to ensure formation of the correct U2 3'end 0.006990.18016&radic&radic&radic&radic&radic&radic&radic&radic S000003189NIF3YGL221CverifiedProtein of unknown function, similar to Listeria monocytogenesmajor sigma factor (rpoD gene product); theauthentic, non-tagged protein is detected inhighly purified mitochondria in high-throughputstudies 0.00690.17949&radic&radic&radic&radic&radic&radic S000006257YPR053CDubiousHypothetical protein 0.00690.17949&radic&radic S000004460YPT7YML001WverifiedGTPase; GTP-binding protein of the rab family; required forhomotypic fusion event in vacuole inheritance,for endosome-endosome fusion, similar tomammalian Rab7 0.006890.17933&radic&radic&radic&radic S000000815PRP22YER013WverifiedDEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase,associates with lariat intermediates before thesecond catalytic step of splicing; mediatesATP-dependent mRNA release from the spliceosomeand unwinds RNA duplexes 0.006890.17933&radic&radic&radic&radic&radic&radic&radic S000003303YGR071CUncharacterizedPutative protein of unknown function; deletion mutant has increased glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the nucleus 0.006870.17829&radic&radic&radic&radic S000000381EHT1YBR177CverifiedAcyl-coenzymeA:ethanol O-acyltransferase that plays a minorrole in medium-chain fatty acid ethyl esterbiosynthesis; contains esterase activity;localizes to lipid particles and themitochondrial outer membrane 0.006850.17829&radic&radic&radic&radic&radic S000006393SKI3YPR189WverifiedProtein involved in exosome mediated 3' to 5' mRNA degradationand translation inhibition of non-poly(A)mRNAs; forms complex with Ski2p and Ski8p;required for repressing propagation of dsRNAviruses 0.006860.17829&radic&radic&radic&radic&radic&radic&radic S000000101PDR3YBL005WverifiedTranscriptional activator of the pleiotropic drug resistancenetwork, regulates expression of ATP-bindingcassette (ABC) transporters through binding tocis-acting sites known as PDREs (PDR responsiveelements) 0.006870.17829&radic&radic&radic&radic&radic S000001229KOG1YHR186CverifiedSubunit of TORC1, a rapamycin-sensitive complex involved ingrowth control that contains Tor1p or Tor2p,Lst8p and Tco89p; contains four HEAT repeatsand seven WD-40 repeats; may act as a scaffoldprotein to couple TOR and its effectors 0.006810.17791&radic&radic&radic&radic S000004563VPS9YML097CverifiedA guanine nucleotide exchange factor involved invesicle-mediated vacuolar protein transport;specifically stimulates the intrinsic guaninenucleotide exchange activity of Vps21p/Rab5:similar to mammalian ras inhibitors; bindsubiquitin 0.006810.17791&radic&radic&radic S000000540GRX1YCL035CverifiedHydroperoxide and superoxide-radical responsive heat-stableglutathione-dependent disulfide oxidoreductasewith active site cysteine pair; protects cellsfrom oxidative damage 0.00680.17733&radic&radic&radic&radic S000005685SME1YOR159CverifiedCore Sm protein Sm E; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm E 0.006790.17733&radic&radic&radic&radic S000000069BUD14YAR014CverifiedProtein involved in bud-site selection, Bud14p-Glc7p complexfunctions as a cortical regulator of dynein;diploid mutants display a random buddingpattern instead of the wild-type bipolarpattern 0.006750.17666&radic&radic&radic&radic&radic&radic&radic S000007496IGO2YHR132W-AuncharacterizedPutative protein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to the cytoplasmand nucleus 0.006780.17666&radic&radic&radic&radic S000005682NFI1YOR156CverifiedSUMO ligase, catalyzes the covalent attachment of SUMO (Smt3p)to proteins; involved in maintenance of propertelomere length 0.006780.17666&radic&radic&radic&radic&radic&radic&radic&radic S000006322YPR118WVerifiedMethylthioribose-1-phosphate isomerase, catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway 0.006770.17666&radic&radic&radic&radic S000000245FAT1YBR041WverifiedFatty acid transporter and very long-chain fatty acyl-CoAsynthetase, may form a complex with Faa1p orFaa4p that imports and activates exogenousfatty acids 0.006750.17639&radic&radic&radic S000003105SEC27YGL137WverifiedEssential beta'-coat protein of the COPI coatomer, involved inER-to-Golgi and Golgi-to-ER transport; containsWD40 domains that mediate cargo selectiveinteractions; 45% sequence identity tomammalian beta'-COP 0.006740.17639&radic&radic&radic S000002218TSR1YDL060WverifiedProtein required for processing of 20S pre-rRNA in thecytoplasm, associates with pre-40S ribosomalparticles 0.006730.17605&radic&radic&radic S000000157SKT5YBL061CverifiedActivator of Chs3p (chitin synthase III), recruits Chs3p to thebud neck via interaction with Bni4p; hassimilarity to Shc1p, which activates Chs3pduring sporulation 0.006730.17605&radic&radic&radic&radic&radic S000000078PRM9YAR031WverifiedPheromone-regulated protein with 3 predicted transmembranesegments and an FF sequence, a motif involvedin COPII binding; member of DUP240 gene family 0.006720.17578&radic&radic&radic&radic&radic&radic S000000230ETR1YBR026Cverified2-enoyl thioester reductase, member of the medium chaindehydrogenase/reductase family; localized to inmitochondria, where it has a probable role infatty acid synthesis 0.006710.17578&radic&radic S000006007ELP3YPL086CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;exhibits histone acetyltransferase activitythat is directed to histones H3 and H4;disruption confers resistance to K. lactiszymotoxin 0.006710.17578&radic&radic&radic&radic&radic S000001132YNG2YHR090CverifiedSubunit of the NuA4 histone acetyltransferase complex thatacetylates histone H4 and H2A; has similarityto the human tumor suppressor ING1 0.006690.1755&radic&radic S000004562YML096WUncharacterizedPutative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10 0.006680.1752&radic&radic&radic S000002837TIF35YDR429CverifiedSubunit of the core complex of translation initiation factor3(eIF3), which is essential for translation 0.006690.1752&radic&radic&radic&radic S000003209DOC1YGL240WverifiedProcessivity factor required for the ubiquitination activity ofthe anaphase promoting complex (APC), mediatesthe activity of the APC by contributing tosubstrate recognition; involved in cyclinproteolysis 0.006650.17302&radic&radic&radic&radic&radic&radic S000002982PUF4YGL014WverifiedMember of the PUF protein family, which is defined by thepresence of Pumilio homology domains thatconfer RNA binding activity; preferentiallybinds mRNAs encoding nucleolar ribosomalRNA-processing factors 0.006650.17302&radic&radic&radic&radic&radic S000003271YGR039WDubiousHypothetical protein 0.006630.17302&radic&radic&radic&radic&radic S000003078CUE3YGL110CuncharacterizedProtein of unknown function; has a CUE domain that bindsubiquitin, which may facilitate intramolecularmonoubiquitination 0.006670.17302&radic&radic S000006365SGV1YPR161CverifiedCyclin (Bur2p)-dependent protein kinase that functions intranscriptional regulation; phosphorylates thecarboxy-terminal domain of Rpo21p, which is thelargest subunit of RNA polymerase II; regulatedby Cak1p 0.006670.17302&radic&radic&radic S000000025YAL027WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YAL027W is a non-essential gene 0.006650.17302&radic&radic&radic&radic&radic&radic S000003897YJR136CUncharacterizedPutative protein of unknown function; may interact with mitochondrial ribosomal protein Rsm23p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.006670.17302&radic&radic&radic S000007522YBR085C-AUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus 0.006620.17302&radic&radic S000002323CDC9YDL164CverifiedDNA ligase found in the nucleus and mitochondria, an essentialenzyme that joins Okazaki fragments during DNAreplication; also acts in nucleotide excisionrepair, base excision repair, and recombination 0.006570.17263&radic&radic&radic S000003044RPL7AYGL076CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl7Bp and has similarity to E.coli L30 and rat L7 ribosomal proteins;contains a conserved C-terminal Nucleic acidBinding Domain (NDB2) 0.006560.17263&radic&radic&radic&radic&radic&radic S000005562PEP12YOR036WverifiedTarget membrane receptor (t-SNARE) for vesicular intermediatestraveling between the Golgi apparatus and thevacuole; controls entry of biosynthetic,endocytic, and retrograde traffic into theprevacuolar compartment; syntaxin 0.006560.17263&radic&radic&radic&radic&radic S000005204YNL260CUncharacterizedPutative protein of unknown function with similarity to a human protein overexpressed in oral cancers; localizes to the nucleus and cytoplasm; YNL260C is an essential gene 0.006570.17263&radic&radic&radic S000005505CTR9YOL145CverifiedComponent of the Paf1p complex, which is a large complex thatbinds to and modulates the activity of RNApolymerase II and is required for expression ofa subset of genes, including cyclin genes;contains TPR repeats 0.006570.17263&radic&radic S000005548YOR022CUncharacterizedHypothetical protein 0.006570.17263&radic&radic&radic&radic&radic S000005820RRS1YOR294WverifiedEssential protein that binds ribosomal protein L11 and isrequired for nuclear export of the 60Spre-ribosomal subunit during ribosomebiogenesis; mouse homolog shows alteredexpression in Huntington's disease model mice 0.006550.17258&radic&radic&radic&radic&radic S000001562SMY1YKL079WverifiedProtein that interacts with Myo2p, proposed to be involved inexocytosis; N-terminal domain is related to themotor domain of kinesins 0.006550.1724&radic&radic&radic&radic S000004873TIF11YMR260CverifiedTranslation initiation factor eIF1A, essential protein thatforms a complex with Sui1p (eIF1) and the 40Sribosomal subunit and scans for the startcodon; C-terminus associates with Fun12p(eIF5B); N terminus interacts with eIF2 andeIF3 0.00650.17149&radic&radic&radic&radic&radic&radic S000005098YCK2YNL154CverifiedPalmitoylated, plasma membrane-bound casein kinase I isoform;shares redundant functions with Yck1p inmorphogenesis, proper septin assembly,endocytic trafficking; provides an essentialfunction overlapping with that of Yck1p 0.006520.17149&radic&radic&radic&radic&radic S000002525APC4YDR118WverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 0.006520.17149&radic&radic&radic&radic&radic&radic&radic&radic S000003212TAD1YGL243WverifiedtRNA-specific adenosine deaminase, deaminates adenosine-37 toinosine in tRNA-Ala 0.006440.17044&radic&radic&radic&radic&radic&radic S000005779NAT5YOR253WverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.006470.17044&radic&radic&radic S000003896MCM22YJR135CverifiedProtein involved in minichromosome maintenance; component ofthe kinetochore; binds to centromeric DNA in aCtf19p-dependent manner 0.006470.17044&radic&radic&radic S000003992NOC3YLR002CverifiedProtein that forms a nuclear complex with Noc2p that binds to66S ribosomal precursors to mediate theirintranuclear transport; also binds to chromatinto promote the association of DNA replicationfactors and replication initiation 0.006480.17044&radic&radic&radic&radic&radic&radic&radic S000003388PTI1YGR156WverifiedPta1p Interacting protein 0.006430.1702&radic&radic&radic&radic S000000003EFB1YAL003WverifiedTranslation elongation factor 1 beta; stimulates nucleotideexchange to regenerate EF-1 alpha-GTP for thenext elongation cycle; part of the EF-1complex, which facilitates binding ofaminoacyl-tRNA to the ribosomal A site 0.006420.17009&radic&radic&radic&radic&radic&radic&radic S000006272HOS1YPR068CverifiedPutative class I histone deacetylase (HDAC) with sequencesimilarity to Hda1p, Rpd3p, Hos2p, and Hos3p;deletion results in increased histoneacetylation at rDNA repeats; interacts with theTup1p-Ssn6p corepressor complex 0.006420.16989&radic&radic S000003368LSB1YGR136WverifiedProtein containing an N-terminal SH3 domain; binds Las17p,which is a homolog of human Wiskott-AldrichSyndrome protein involved in actin patchassembly and actin polymerization 0.006410.16989&radic&radic&radic&radic&radic S000003213RTF1YGL244WverifiedSubunit of the RNA polymerase II-associated Paf1 complex;directly or indirectly regulates DNA-bindingproperties of Spt15p and relative activities ofdifferent TATA elements; involved in telomeremaintenance 0.006390.16913&radic&radic&radic S000005167ATG4YNL223WverifiedCysteine protease required for autophagy; cleaves Atg8p to aform required for autophagosome and Cvt vesiclegeneration; mediates attachment ofautophagosomes to microtubules throughinteractions with Tub1p and Tub2p 0.006380.16913&radic&radic&radic&radic&radic&radic&radic S000004955YNL010WUncharacterizedPutative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation 0.006370.16877&radic&radic&radic&radic S000005830YOR304C-AUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck 0.006360.16877&radic&radic&radic&radic S000003507RTT102YGR275WverifiedComponent of both the SWI/SNF and RSC chromatin remodelingcomplexes, suggested role in chromosomemaintenance; possible weak regulator of Ty1transposition 0.006350.1685&radic&radic&radic S000002848DOT1YDR440WverifiedNucleosomal histone H3-Lys79 methylase, associates withtranscriptionally active genes, functions ingene silencing at telomeres, most likely bydirectly modulating chromatin structure and Sirprotein localization &radic0.006340.1685&radic&radic S000003325YGR093WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus 0.006330.16823&radic&radic&radic S000001311DFG10YIL049WverifiedProtein of unknown function, involved in filamentous growth 0.006330.16803&radic&radic&radic&radic&radic S000004234MAP1YLR244CverifiedMethionine aminopeptidase, catalyzes the cotranslationalremoval of N-terminal methionine from nascentpolypeptides; function is partially redundantwith that of Map2p 0.006330.16803&radic&radic&radic&radic S000003567MAD2YJL030WverifiedComponent of the spindle-assembly checkpoint complex, whichdelays the onset of anaphase in cells withdefects in mitotic spindle assembly; forms acomplex with Mad1p 0.006330.16803&radic&radic&radic&radic S000005677RPB2YOR151CverifiedRNA polymerase II second largest subunit B150, part of centralcore; similar to bacterial beta subunit 0.00630.16738&radic&radic&radic&radic S000004665RNA14YMR061WverifiedCleavage and polyadenylation factor I (CF I) component involvedin cleavage and polyadenylation of mRNA 3'ends; bridges interaction between Rna15p andHrp1p in the CF I complex 0.00630.16738&radic&radic S000003700TPK1YJL164CverifiedSubunit of cytoplasmic cAMP-dependent protein kinase, whichcontains redundant catalytic subunits Tpk1p,Tpk2p, and Tpk3p and regulatory subunit Bcy1p;promotes vegetative growth in response tonutrients; inhibits filamentous growth 0.006310.16738&radic&radic&radic&radic&radic&radic S000000294YBR090CUncharacterizedHypothetical protein 0.006260.1666&radic&radic&radic S000004735ECM16YMR128WverifiedEssential DEAH-box ATP-dependent RNA helicase specific to theU3 snoRNP, predominantly nucleolar indistribution, required for 18S rRNA synthesis 0.006260.1666&radic&radic S000002923SLF1YDR515WverifiedRNA binding protein that associates with polysomes; proposed tobe involved in regulating mRNA translation;involved in the copper-dependent mineralizationof copper sulfide complexes on cell surface incells cultured in copper salts 0.006260.1666&radic S000002284CDC48YDL126CverifiedATPase in ER, nuclear membrane and cytosol with homology tomammalian p97; in a complex with Npl4p andUfd1p participates in retrotranslocation ofubiquitinated proteins from the ER into thecytosol for degradation by the proteasome 0.006250.1666&radic&radic&radic S000002573SEC5YDR166CverifiedEssential 107kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which has the essential function ofmediating polarized targeting of secretoryvesicles to active sites of exocytosis 0.006280.1666&radic&radic&radic S000002483RAD55YDR076WverifiedProtein that stimulates strand exchange by stabilizing thebinding of Rad51p to single-stranded DNA;involved in the recombinational repair ofdouble-strand breaks in DNA during vegetativegrowth and meiosis; forms heterodimer withRad57p 0.006260.1666&radic&radic&radic&radic&radic&radic&radic S000001104RPP1YHR062CverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends 0.006240.16627&radic&radic&radic&radic&radic&radic S000003893NMD5YJR132WverifiedKaryopherin, a carrier protein involved in nuclear import ofproteins; importin beta homolog 0.006240.16627&radic&radic&radic&radic S000003487COQ6YGR255CverifiedPutative flavin-dependent monooxygenase, involved in ubiquinone(Coenzyme Q) biosynthesis; located on thematrix side of the mitochondrial inner membrane 0.006230.16563&radic&radic S000005619YOR093CUncharacterizedHypothetical protein 0.006230.16563&radic&radic&radic&radic&radic&radic S000003451YGR219WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C 0.006220.16563&radic&radic&radic&radic&radic&radic S000000832CHZ1YER030WuncharacterizedPutative chaperone for Htz1p/H2A-H2B dimer 0.006210.16563&radic&radic&radic&radic&radic&radic S000001250SET5YHR207CverifiedZinc-finger protein of unknown function, contains one canonicaland two unusual fingers in unusualarrangements; deletion enhances replication ofpositive-strand RNA virus 0.006230.16563&radic&radic&radic&radic&radic S000000975RAD24YER173WverifiedCheckpoint protein, involved in the activation of the DNAdamage and meiotic pachytene checkpoints;subunit of a clamp loader that loadsRad17p-Mec3p-Ddc1p onto DNA; homolog of humanand S. pombe Rad17 protein 0.006190.16491&radic&radic&radic&radic S000001907YFR011CUncharacterizedPutative protein of unknown function; localizes to the mitochondrion; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR011C is not an essential gene 0.006160.16432&radic&radic&radic&radic&radic S000002776YPR1YDR368Wverified2-methylbutyraldehyde reductase, may be involved in isoleucinecatabolism 0.006160.16432&radic&radic S000005725YOR199WDubiousHypothetical protein 0.006140.16418&radic&radic&radic&radic S000005511GRE2YOL151WverifiedNADPH-dependent methylglyoxal reductase (D-lactaldehydedehydrogenase); stress induced (osmotic, ionic,oxidative, heat shock and heavy metals);regulated by the HOG pathway 0.006080.16123&radic&radic&radic S000003180VAM7YGL212WverifiedComponent of the vacuole SNARE complex involved in vacuolarmorphogenesis; SNAP-25 homolog; functions witha syntaxin homolog Vam3p in vacuolar proteintrafficking 0.006040.16123&radic&radic&radic S000000458TRS20YBR254CverifiedOne of 10 subunits of the transport protein particle (TRAPP)complex of the cis-Golgi which mediates vesicledocking and fusion; mutations in the humanhomolog cause the spondyloepiphyseal dysplasiatarda (SEDL) disorder 0.006070.16123&radic&radic&radic&radic&radic&radic S000001164YHR122WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; may be involved in transcription; YHR122W is an essential gene 0.006080.16123&radic&radic&radic&radic&radic S000002372NOP6YDL213CuncharacterizedProtein with similarity to hydrophilins, which are involved inthe adaptive response to hyperosmoticconditions; computational analysis oflarge-scale protein-protein interaction datasuggests a possible role in rRNA processing 0.006080.16123&radic S000000004SSA1YAL005CverifiedATPase involved in protein folding and nuclear localizationsignal (NLS)-directed nuclear transport; memberof heat shock protein 70 (HSP70) family; formsa chaperone complex with Ydj1p; localized tothe nucleus, cytoplasm, and cell wall 0.006130.16123&radic&radic&radic&radic&radic S000002473YDR066CUncharacterizedHypothetical protein 0.006070.16123&radic&radic&radic&radic&radic S000004260DCS1YLR270WverifiedNon-essential hydrolase involved in mRNA decapping, mayfunction in a feedback mechanism to regulatedeadenylation, contains pyrophosphataseactivity and a HIT (histidine triad) motif;interacts with neutral trehalase Nth1p 0.006090.16123&radic&radic&radic&radic&radic&radic&radic S000004697NPL6YMR091CverifiedComponent of the RSC chromatin remodeling complex; interactswith Rsc3p, Rsc30p, Ldb7p, and Htl1p to form amodule important for a broad range of RSCfunctions; involved in nuclear protein importand maintenance of proper telomere length 0.00610.16123&radic&radic&radic S000002474OCA6YDR067CuncharacterizedCytoplasmic protein required for replication of Brome mosaicvirus in S. cerevisiae, which is a model systemfor studying replication of positive-strand RNAviruses in their natural hosts 0.006130.16123&radic&radic&radic&radic S000003256THG1YGR024CverifiedtRNAHis guanylyltransferase, adds a guanosine residue to the 5'end of tRNAHis after transcription and RNase Pcleavage; couples nuclear division andmigration to cell budding and cytokinesis;essential enzyme conserved among eukaryotes 0.006060.16123&radic&radic&radic&radic S000001743OPI8YKR035CdubiousDubious open reading frame unlikely to encode a protein, basedon available experimental and comparativesequence data; partially overlaps verified geneDID2/YKR035W-A 0.006010.16098&radic&radic S000002161MCD1YDL003WverifiedEssential protein required for sister chromatid cohesion inmitosis and meiosis; subunit of the cohesincomplex; expression is cell cycle regulated andpeaks in S phase 0.005990.16031&radic&radic&radic S000001463YIR024CUncharacterizedPutative protein of unknown function; GFP-fusion protein localizes to mitochondria and native protein copurifies with mitochondria; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect 0.005990.16031&radic&radic&radic&radic S000002311YDL152WDubiousHypothetical protein; open reading frame overlaps 5' end of essential SAS10 gene encoding a component of the small ribosomal subunit processosome 0.0060.16031&radic&radic&radic&radic S000002874PKH3YDR466WverifiedProtein kinase with similarity to mammalianphosphoinositide-dependent kinase 1 (PDK1) andyeast Pkh1p and Pkh2p, two redundant upstreamactivators of Pkc1p; identified as a multicopysuppressor of a pkh1 pkh2 double mutant 0.006010.16031&radic&radic S000000849SAP1YER047CverifiedPutative ATPase of the AAA family, interacts with the Sin1ptranscriptional repressor in the two-hybridsystem 0.0060.16031&radic&radic&radic&radic&radic S000000683YCR087WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene 0.005980.16025&radic&radic S000000193BRN1YBL097WverifiedEssential protein required for chromosome condensation, likelyto function as an intrinsic component of thecondensation machinery, may influence multipleaspects of chromosome transmission and dynamics 0.005980.16025&radic&radic&radic S000004072SRL2YLR082CverifiedProtein of unknown function; overexpression suppresses thelethality caused by a rad53 null mutation 0.005980.16025&radic&radic&radic&radic S000001597APN1YKL114CverifiedMajor apurinic/apyrimidinic endonuclease, 3'-repair diesteraseinvolved in repair of DNA damage by oxidationand alkylating agents; also functions as a3'-5' exonuclease to repair7,8-dihydro-8-oxodeoxyguanosine 0.005950.15958&radic&radic&radic&radic&radic&radic S000003833NPA3YJR072CverifiedEssential, conserved, cytoplasmic ATPase; phosphorylated by thePcl1p-Pho85p kinase complex 0.005960.15958&radic&radic&radic S000000066SEN34YAR008WverifiedSubunit of the tRNA splicing endonuclease, which is composed ofSen2p, Sen15p, Sen34p, and Sen54p; Sen34pcontains the active site for tRNA 3' splicesite cleavage and has similarity to Sen2p andto Archaeal tRNA splicing endonuclease 0.005960.15958&radic&radic&radic&radic&radic&radic&radic S000003214GUS1YGL245WverifiedGlutamyl-tRNA synthetase (GluRS), forms a complex withmethionyl-tRNA synthetase (Mes1p) and Arc1p;complex formation increases the catalyticefficiency of both tRNA synthetases and ensurestheir correct localization to the cytoplasm 0.005950.15958&radic&radic&radic&radic&radic S000003737ECM25YJL201WverifiedNon-essential protein of unknown function; promoter contains aconsensus binding sequence for factor Abf1p 0.005940.15814&radic&radic S000005873REV1YOR346WverifiedDeoxycytidyl transferase, forms a complex with the subunits ofDNA polymerase zeta, Rev3p and Rev7p; involvedin repair of abasic sites in damaged DNA 0.005940.15814&radic&radic&radic&radic S000004550TUB1YML085CverifiedAlpha-tubulin; associates with beta-tubulin (Tub2p) to formtubulin dimer, which polymerizes to formmicrotubules 0.005930.15814&radic S000005724BFR1YOR198CverifiedComponent of mRNP complexes associated with polyribosomes;implicated in secretion and nuclearsegregation; multicopy suppressor of BFA(Brefeldin A) sensitivity 0.005940.15814&radic&radic&radic&radic S000002186MPS1YDL028CverifiedDual-specificity kinase required for spindle pole body (SPB)duplication and spindle checkpoint function;substrates include SPB proteins Spc42p,Spc110p, and Spc98p, mitotic exit networkprotein Mob1p, and checkpoint protein Mad1p 0.005940.15814&radic&radic S000006236SRO7YPR032WverifiedPutative effector of Rab GTPase Sec4p, forms a complex withSec4p and t-SNARE Sec9p; involved in exocytosisand docking and fusion of post-Golgi vesicleswith plasma membrane; homolog of Sro77p andDrosophila lgl tumor suppressor 0.005890.15796&radic&radic&radic S000002299RPO21YDL140CverifiedRNA polymerase II largest subunit B220, part of central core;phosphorylation of C-terminal heptapeptiderepeat domain regulates association withtranscription and splicing factors; similar tobacterial beta-prime 0.005880.1576&radic&radic S000003594BIT61YJL058CverifiedSubunit of TORC2(Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p-Slm1p-Slm2p), a membrane-associated complex thatregulates cell cycle-dependent actincytoskeletal dynamics during polarized growthand cell wall integrity 0.005880.1576&radic&radic&radic&radic S000003199YGL230CUncharacterizedHypothetical protein 0.005880.1576&radic&radic&radic&radic S000004560RAD10YML095CverifiedSingle-stranded DNA endonuclease (with Rad1p), cleavessingle-stranded DNA during nucleotide excisionrepair and double-strand break repair; subunitof Nucleotide Excision Repair Factor 1 (NEF1);homolog of human ERCC1 protein 0.005860.15708&radic&radic&radic&radic S000003879ILM1YJR118CverifiedProtein of unknown function; may be involved in mitochondrialDNA maintenance; required for slowed DNAsynthesis-induced filamentous growth 0.005860.15708&radic&radic S000000561YCL056CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.005860.15708&radic&radic&radic&radic&radic S000005651CAT5YOR125CverifiedMitochondrial inner membrane protein directly involved inubiquinone biosynthesis, essential for severalother metabolic pathways including respirationand gluconeogenic gene activation 0.005860.15708&radic&radic&radic&radic S000003348SPT6YGR116WverifiedEssential protein that interacts with histones and is involvedin nucleosome disassembly and reassembly duringtranscription elongation 0.005840.15678&radic&radic&radic S000000358RPB5YBR154CverifiedRNA polymerase subunit ABC27, common to RNA polymerases I, II,and III; contacts DNA and affectstransactivation 0.005840.15678&radic&radic S000001537DEF1YKL054CverifiedRNAPII degradation factor, forms a complex with Rad26p inchromatin, enables ubiquitination andproteolysis of RNAPII present in an elongationcomplex 0.005820.15654&radic&radic S000000745MMS21YEL019CverifiedSUMO ligase involved in chromosomal organization and DNArepair; essential subunit of theMms21-Smc5-Smc6 complex; mutants are sensitiveto methyl methanesulfonate and show increasedspontaneous mutation and mitotic recombination 0.005810.15631&radic&radic&radic S000003954GPI13YLL031CverifiedER membrane localized phosphoryltransferase that addsphosphoethanolamine onto the third mannoseresidue of the glycosylphosphatidylinositol(GPI) anchor precursor; similar to human PIG-Oprotein 0.005820.15631&radic&radic&radic&radic S000005775APC5YOR249CverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 0.005820.15631&radic&radic&radic&radic&radic S000006330YPR126CDubiousHypothetical protein 0.005820.15631&radic&radic S000004527MFT1YML062CverifiedSubunit of the THO complex, which is a nuclear complexcomprised of Hpr1p, Mft1p, Rlr1p, and Thp2p,that is involved in transcription elongationand mitotic recombination; involved in telomeremaintenance 0.005790.15567&radic&radic&radic&radic S000003740RCY1YJL204CverifiedF-box protein involved in recycling plasma membrane proteinsinternalized by endocytosis; localized to sitesof polarized growth 0.00580.15567&radic&radic&radic&radic S000002201PRP11YDL043CverifiedSubunit of the SF3a splicing factor complex, required forspliceosome assembly 0.005790.15567&radic&radic&radic S000002618YDR210WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery 0.00580.15567&radic&radic&radic S000001243RPN10YHR200WverifiedNon-ATPase base subunit of the 19S regulatory particle (RP) ofthe 26S proteasome; N-terminus plays a role inmaintaining the structural integrity of the RP;binds selectively to polyubiquitin chains;homolog of the mammalian S5a protein 0.00580.15567&radic&radic&radic&radic S000003142BUD13YGL174WverifiedSubunit of the RES complex, which is required for nuclearpre-mRNA retention and splicing; involved inbud-site selection; diploid mutants display aunipolar budding pattern instead of thewild-type bipolar pattern 0.005770.15445&radic&radic&radic&radic&radic S000005686MTR10YOR160WverifiedNuclear import receptor, mediates the nuclear localization ofproteins involved in mRNA-nucleus export 0.005770.15445&radic&radic&radic&radic&radic&radic S000002315YDL156WUncharacterizedHypothetical protein 0.005760.15445&radic&radic&radic&radic S000000633PHO87YCR037CverifiedLow-affinity inorganic phosphate (Pi) transporter, involved inactivation of PHO pathway; expression isindependent of Pi concentration and Pho4pactivity; contains 12 membrane-spanningsegments 0.005780.15445&radic&radic S000001173YHR131CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.005750.15445&radic&radic&radic S000003332MDR1YGR100WverifiedCytoplasmic GTPase-activating protein for Ypt/Rab transportGTPases Ypt6p, Ypt31p and Sec4p; involved inrecycling of internalized proteins andregulation of Golgi secretory function 0.005740.15445&radic&radic S000002271ATG20YDL113CverifiedProtein required for transport of aminopeptidase I (Lap4p)through the cytoplasm-to-vacuole targetingpathway; bindsphosphatidylinositol-3-phosphate, involved inlocalization of membranes to thepreautophagosome, potential Cdc28p substrate 0.005780.15445&radic&radic S000002211PBP4YDL053CverifiedPbp1p binding protein, interacts strongly with Pab1p-bindingprotein 1 (Pbp1p) in the yeast two-hybridsystem; also interacts with Lsm12p in acopurification assay 0.005740.15445&radic&radic&radic&radic&radic S000001939IRC6YFR043CuncharacterizedHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 0.005770.15445&radic&radic&radic&radic S000002232BRE1YDL074CverifiedE3 ubiquitin ligase for Rad6p, required for the ubiquitinationof histone H2B, recruitment of Rad6p topromoter chromatin and subsequent methylationof histone H3 (on L4 and L79), contains RINGfinger domain 0.005730.15435&radic&radic&radic&radic S000001575BUD2YKL092CverifiedGTPase activating factor for Rsr1p/Bud1p required for bothaxial and bipolar budding patterns; mutantsexhibit random budding in all cell types 0.005720.15421&radic&radic&radic&radic&radic&radic&radic S000003509YGR277CUncharacterizedPutative protein of unknown function; sequence similarity to Pantetheine-phosphate adenylyltransferase (PPAT); YGR277C is an essential gene 0.005720.15383&radic&radic&radic S000002254OPI6YDL096CdubiousDubious open reading frame unlikely to encode a protein, basedon available experimental and comparativesequence data; partially overlaps verified genePMT1/YDL095W; YDL096C is not essential 0.005710.15383&radic&radic S000001292SSM4YIL030CverifiedUbiquitin-protein ligase of the ER/nuclear envelope, requiredfor degradation of Alpha2p and other proteinscontaining a Deg1 degradation signal; ssm4mutation suppresses mRNA instability caused byan rna14 mutation 0.005710.15383&radic&radic S000006381YPR177CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex 0.005710.15383&radic&radic&radic&radic&radic S000000452HIS7YBR248CverifiedImidazole glycerol phosphate synthase (glutamineamidotransferase:cyclase), catalyzes the fifthand sixth steps of histidine biosynthesis andalso produces 5-aminoimidazole-4-carboxamideribotide (AICAR), a purine precursor 0.005710.15364&radic&radic&radic&radic&radic&radic S000006119RPL7BYPL198WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl7Ap and has similarity to E.coli L30 and rat L7 ribosomal proteins;contains a conserved C-terminal Nucleic acidBinding Domain (NDB2) 0.00570.15364&radic&radic&radic&radic&radic S000000678AHC2YCR082WuncharacterizedProtein of unknown function, putative transcriptionalregulator; proposed to be a Ada Histoneacetyltransferase complex component; GFP taggedprotein is localized to the cytoplasm andnucleus 0.00570.15364&radic&radic&radic S000003782REC107YJR021CverifiedProtein involved in early stages of meiotic recombination;involved in altering chromatin structure at DNAdouble-stranded break sites and in coordinationbetween the initiation of recombination and thefirst division of meiosis 0.005690.15334&radic&radic&radic S000004574URA5YML106WverifiedOne of two orotate phosphoribosyltransferase isozymes (see alsoURA10) that catalyze the fifth enzymatic stepin de novo biosynthesis of pyrimidines,converting orotate into orotidine-5'-phosphate 0.00570.15334&radic&radic&radic&radic S000002545HPR1YDR138WverifiedSubunit of THO/TREX complexes that couple transcriptionelongation with mitotic recombination and withmRNA metabolism and export, subunit of an RNAPol II complex; regulates lifespan; involved intelomere maintenance; similar to Top1p 0.005670.1528&radic&radic&radic&radic&radic S000002796RVS167YDR388WverifiedActin-associated protein, subunit of a complex(Rvs161p-Rvs167p) involved in regulation ofactin cytoskeleton, endocytosis, and viabilityfollowing starvation or osmotic stress; homologof mammalian amphiphysin 0.005680.1528&radic&radic&radic S000004769ATG16YMR159CverifiedProtein that interacts with the Atg12p-Atg5p conjugate duringformation of the pre-autophagosomal structure;essential for autophagy 0.005680.1528&radic&radic&radic&radic S000002458YDR051CUncharacterizedHypothetical protein 0.005690.1528&radic&radic&radic&radic&radic S000002360TRM8YDL201WverifiedSubunit of a tRNA methyltransferase complex composed of Trm8pand Trm82p that catalyzes 7-methylguanosinemodification of tRNA &radic0.005660.15272&radic S000005203ATX1YNL259CverifiedCytosolic copper metallochaperone that transports copper to thesecretory vesicle copper transporter Ccc2p foreventual insertion into Fet3p, which is amulticopper oxidase required for high-affinityiron uptake 0.005660.15272&radic&radic&radic&radic S000003059NBP35YGL091CverifiedEssential P-loop NTPase that functions in nuclear and cytosoliciron-sulfur (FeS) protein assembly; has ahighly conserved N-terminus 0.005660.15272&radic&radic&radic S000003346YGR114CDubiousHypothetical protein; open reading frame overlaps 5' end of essential SPT6 gene involved in nucleosome disassembly and reassembly during transcription 0.005660.15272&radic&radic&radic&radic&radic&radic S000002544RGP1YDR137WverifiedSubunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) thatcatalyzes nucleotide exchange on Ypt6p 0.005640.15084&radic&radic&radic&radic&radic S000004738RRB1YMR131CverifiedEssential nuclear protein involved in early steps of ribosomebiogenesis; physically interacts with theribosomal protein Rpl3p 0.005620.15084&radic&radic&radic S000004765TPP1YMR156CverifiedDNA 3'-phosphatase that functions in repair of endogenousdamage of double-stranded DNA, activity isspecific for removal of 3' phosphates at strandbreaks; has similarity to the l-2-haloaciddehalogenase superfamily 0.005640.15084&radic&radic&radic&radic S000001571YKL088WUncharacterizedPredicted phosphopantothenoylcysteine decarboxylase, may be involved in coenzyme A biosynthesis; interacts with Sis2p and Vhs3p 0.005610.15084&radic&radic&radic&radic S000002371SHR3YDL212WverifiedEndoplasmic reticulum packaging chaperone, required forincorporation of amino acid permeases intoCOPII coated vesicles for transport to the cellsurface 0.005610.15084&radic S000004022RAD5YLR032WverifiedSingle-stranded DNA-dependent ATPase, involved inpostreplication repair; contains RING fingerdomain 0.005650.15084&radic&radic&radic&radic S000002499UBC13YDR092WverifiedUbiquitin-conjugating enzyme involved in the error-free DNApostreplication repair pathway; interacts withMms2p to assemble ubiquitin chains at the UbLys-63 residue; DNA damage triggersredistribution from the cytoplasm to thenucleus 0.005630.15084&radic&radic S000004576YML108WUncharacterizedPutative protein of unknown function whose structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene 0.005650.15084&radic&radic&radic&radic&radic S000002303YDL144CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene. 0.00560.15084&radic&radic&radic&radic S000003143SAE2YGL175CverifiedProtein with a role in accurate meiotic and mitoticdouble-strand break repair; phosphorylated inresponse to DNA damage and required for normalresistance to DNA-damaging agents 0.005610.15084&radic&radic&radic&radic&radic S000003750HXT8YJL214WverifiedProtein of unknown function with similarity to hexosetransporter family members, expression isinduced by low levels of glucose and repressedby high levels of glucose 0.005610.15084&radic&radic&radic&radic S000002903VPS3YDR495CverifiedCytoplasmic protein required for the sorting and processing ofsoluble vacuolar proteins, acidification of thevacuolar lumen, and assembly of the vacuolarH+-ATPase 0.00560.15084&radic&radic S000002498RLI1YDR091CverifiedEssential iron-sulfur protein required for ribosome biogenesisand translation initiation; facilitates bindingof a multifactor complex (MFC) of translationinitiation factors to the small ribosomalsubunit; predicted ABC family ATPase 0.005580.15009&radic&radic&radic S000000539LSB5YCL034WverifiedProtein of unknown function; binds Las17p, which is a homologof human Wiskott-Aldrich Syndrome proteininvolved in actin patch assembly and actinpolymerization 0.005590.15009&radic&radic&radic&radic&radic&radic S000005377ESC8YOL017WverifiedProtein involved in telomeric and mating-type locus silencing,interacts with Sir2p and also interacts withthe Gal11p, which is a component of the RNA polII mediator complex 0.005580.15009&radic&radic&radic&radic&radic S000006392MLC2YPR188CuncharacterizedRegulatory light chain for the type II myosin, Myo1p; binds toan IQ motif of Myo1p, localization to the budneck depends on Myo1p; involved in thedisassembly of the Myo1p ring 0.005590.15009&radic&radic&radic&radic&radic S000004223EST1YLR233CverifiedTLC1 RNA-associated factor involved in telomere lengthregulation as the recruitment subunit of thetelomerase holoenzyme, has a possible role inactivating Est2p-TLC1-RNA bound to the telomere 0.00560.15009&radic&radic&radic S000004546YML081WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YML081w is not an essential gene 0.005560.14995&radic S000001225YHR182WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm 0.005560.14995&radic&radic&radic S000003681SFH5YJL145WverifiedPutative phosphatidylinositol transfer protein (PITP), exhibitsphosphatidylinositol- but notphosphatidylcholine-transfer activity, mainlylocalized to cytosol and microsomes, similar toSec14p; may be PITP regulator rather thanactual PITP 0.005550.14955&radic&radic&radic&radic&radic S000004818PFK2YMR205CverifiedBeta subunit of heterooctameric phosphofructokinase involved inglycolysis, indispensable for anaerobic growth,activated by fructose-2,6-bisphosphate and AMP,mutation inhibits glucose induction of cellcycle-related genes 0.005550.14955&radic&radic&radic&radic&radic S000004368PSY3YLR376CuncharacterizedProtein of unknown function; deletion results in a mutatorphenotype suggesting a role for this protein asa mutational suppressor; deletion increasessensitivity to anticancer drugs oxaliplatin andcisplatin but not mitomycin C 0.005550.14955&radic&radic&radic&radic S000004265SMD2YLR275WverifiedCore Sm protein Sm D2; part of heteroheptameric complex (withSmb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D2 0.005540.14922&radic&radic&radic&radic&radic&radic S000002908RPL37BYDR500CverifiedProtein component of the large (60S) ribosomal subunit, hassimilarity to Rpl37Ap and to rat L37 ribosomalprotein 0.00550.1479&radic&radic&radic S000002830SIP1YDR422CverifiedAlternate beta-subunit of the Snf1p kinase complex, may confersubstrate specificity; vacuolar proteincontaining KIS (Kinase-Interacting Sequence)and ASC (Association with Snf1 kinase Complex)domains involved in protein interactions 0.005510.1479&radic&radic&radic&radic S000000663SED4YCR067CverifiedIntegral endoplasmic reticulum membrane protein, functions as apositive regulator of Sar1p probably throughinhibition of GTPase activation by Sec23p;binds Sec16p, participates in vesicleformation, similar to Sec12p 0.005520.1479&radic&radic S000003715PFD1YJL179WverifiedSubunit of heterohexameric prefoldin, which binds cytosolicchaperonin and transfers target proteins to it;involved in the biogenesis of actin and ofalpha- and gamma-tubulin 0.005520.1479&radic&radic&radic&radic&radic&radic S000003249YGR017WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm 0.005520.1479&radic&radic&radic&radic&radic&radic S000000056BDH1YAL060WverifiedNAD-dependent (2R,3R)-2,3-butanediol dehydrogenase, azinc-containing medium-chain alcoholdehydrogenase, produces 2,3-butanediol fromacetoin during fermentation and allows using2,3-butanediol as a carbon source duringaerobic growth 0.00550.1479&radic&radic&radic&radic&radic S000003398KRE11YGR166WverifiedProtein involved in biosynthesis of cell wall beta-glucans;subunit of the TRAPP (transport proteinparticle) complex, which is involved in thelate steps of endoplasmic reticulum to Golgitransport 0.00550.1479&radic&radic&radic&radic S000003510CWC22YGR278WverifiedEssential protein, component of a complex containing Cef1p, hassimilarity to S. pombe Cwf22p; putativespliceosomal component, based on computationalanalysis of large-scale protein-proteininteraction data 0.005480.1479&radic&radic&radic&radic&radic S000000062SEO1YAL067CverifiedPutative permease, member of the allantoate transportersubfamily of the major facilitator superfamily;mutation confers resistance to ethioninesulfoxide 0.005520.1479&radic&radic&radic&radic&radic S000000868YER066WUncharacterizedHypothetical protein 0.005480.1479&radic S000002524TMA64YDR117CverifiedProtein of unknown function that associates with ribosomes; hasa putative RNA binding domain 0.005490.1479&radic&radic&radic S000003245SNU71YGR013WverifiedComponent of U1 snRNP required for mRNA splicing viaspliceosome; yeast specific, no metazoancounterpart 0.005490.1479&radic&radic&radic&radic&radic&radic S000001167YHR125WDubiousHypothetical protein 0.005510.1479&radic&radic&radic S000001849SEC53YFL045CverifiedPhosphomannomutase, involved in synthesis of GDP-mannose anddolichol-phosphate-mannose; required forfolding and glycosylation of secretory proteinsin the ER lumen 0.00550.1479&radic&radic&radic&radic&radic&radic&radic S000001745SPC34YKR037CverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; also localized tonuclear side of spindle pole body 0.005470.14757&radic&radic&radic&radic S000000156YBL060WUncharacterizedHypothetical protein 0.005470.14757&radic&radic&radic&radic S000003693FAR1YJL157CverifiedCyclin-dependent kinase inhibitor that mediates cell cyclearrest in response to pheromone; also forms acomplex with Cdc24p, Ste4p, and Ste18p that mayspecify the direction of polarized growthduring mating; potential Cdc28p substrate 0.005470.14757&radic&radic&radic&radic&radic S000002764SPC110YDR356WverifiedInner plaque spindle pole body (SPB) component, ortholog ofhuman kendrin; involved in connecting nuclearmicrotubules to SPB; interacts withTub4p-complex and calmodulin; phosphorylated byMps1p in cell cycle-dependent manner 0.005460.14592&radic&radic&radic S000002229IRC1YDL071CdubiousHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 0.005450.14592&radic&radic S000003796RAD26YJR035WverifiedProtein involved in transcription-coupled repair nucleotideexcision repair of UV-induced DNA lesions;homolog of human CSB protein 0.005450.14592&radic&radic&radic S000000216YBR012CDubiousHypothetical protein 0.005410.14592&radic S000004393DUS3YLR401CuncharacterizedDihydrouridine synthase, member of a widespread family ofconserved proteins including Smm1p, Dus1p, andDus4p; contains a consensus oleate responseelement (ORE) in its promoter region 0.005420.14592&radic&radic&radic&radic&radic S000002838CYM1YDR430CverifiedLysine-specific metalloprotease of the mitochondrialintermembrane space, member of the pitrilysinfamily; degrades proteins and presequencepeptides cleaved from imported proteins;required for normal mitochondrial morphology 0.005450.14592&radic&radic&radic&radic&radic S000005567YOR041CDubiousDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance 0.005460.14592&radic&radic&radic&radic&radic S000001175NSG1YHR133CverifiedProtein involved in regulation of sterol biosynthesis;specifically stabilizes Hmg2p, one of twoHMG-CoA isoenzymes that catalyze therate-limiting step in sterol biosynthesis;homolog of mammalian INSIG proteins 0.005430.14592&radic&radic&radic S000002304COP1YDL145CverifiedAlpha subunit of COPI vesicle coatomer complex, which surroundstransport vesicles in the early secretorypathway 0.005420.14592&radic S000002261QRI1YDL103CverifiedUDP-N-acetylglucosamine pyrophosphorylase, catalyzes theformation of UDP-N-acetylglucosamine(UDP-GlcNAc), which is important in cell wallbiosynthesis, protein N-glycosylation, and GPIanchor biosynthesis 0.005450.14592&radic&radic&radic&radic S000005459YOL099CDubiousHypothetical protein 0.005430.14592&radic&radic S000004389AFG2YLR397CverifiedATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexamericcomplex; may be involved in degradation ofaberrant mRNAs 0.005460.14592&radic&radic&radic&radic S000002226YDL068WDubiousHypothetical protein 0.005450.14592&radic&radic S000002586CSN9YDR179CverifiedSubunit of the Cop9 signalosome, which is required fordeneddylation, or removal of the ubiquitin-likeprotein Rub1p from Cdc53p (cullin); involved inadaptation to pheromone signaling 0.005430.14592&radic&radic&radic&radic&radic S000004267YSH1YLR277CverifiedPutative endonuclease, subunit of the mRNA cleavage andpolyadenylation specificity complex requiredfor 3' processing of mRNAs 0.005390.14568&radic&radic&radic&radic&radic S000003743LAA1YJL207CverifiedProtein of unknown function, proposed to function as a largeAP-1 accessory protein; colocalizes withclathrin to the late-Golgi apparatus; YJL207Cis a non-essential gene 0.005390.14519&radic&radic&radic S000002194PUS9YDL036CverifiedMitochondrial tRNA pseudouridine synthase involved inpseudouridylation of mitochondrial tRNAs atposition 32 0.005380.14519&radic&radic&radic&radic S000002209LHP1YDL051WverifiedRNA binding protein required for maturation of tRNA and snRNAprecursors; acts as a molecular chaperone forRNAs transcribed by polymerase III; homologousto human La (SS-B) autoantigen 0.005380.14519&radic&radic S000003957RIX7YLL034CverifiedPutative ATPase of the AAA family, required for export ofpre-ribosomal large subunits from the nucleus;distributed between the nucleolus, nucleoplasm,and nuclear periphery depending on growthconditions 0.005370.14519&radic&radic&radic&radic&radic&radic S000001451SQT1YIR012WverifiedEssential protein involved in a late step of 60S ribosomalsubunit assembly or modification; containsmultiple WD repeats; interacts with Qsr1p in atwo-hybrid assay 0.005380.14519&radic&radic S000001554YKL071WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.005380.14519&radic&radic&radic&radic S000001558YKL075CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin 0.005350.14468&radic&radic&radic&radic S000003949HSP104YLL026WverifiedHeat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p(Hsp70) to refold and reactivate previouslydenatured, aggregated proteins; responsive tostresses including: heat, ethanol, and sodiumarsenite; involved in [PSI+] propagation 0.005350.14468&radic&radic&radic&radic S000000132YBL036CVerifiedSingle-domain racemase, possibly non-specific due to the lack of the second domain, which presumably determines specificity 0.005370.14468&radic&radic&radic S000003956IRC19YLL033WuncharacterizedPutative protein of unknown function; YLL033W is not anessential gene but mutant is defective in sporeformation; null mutant displays increasedlevels of spontaneous Rad52 foci 0.005350.14468&radic&radic&radic&radic&radic&radic S000004734SAS2YMR127CverifiedHistone acetyltransferase (HAT) catalytic subunit of the SAScomplex (Sas2p-Sas4p-Sas5p), which acetylatesfree histones and nucleosomes and regulatestranscriptional silencing; member of theMYSTacetyltransferase family 0.005370.14468&radic&radic&radic&radic S000000853JHD1YER051WverifiedJmjC domain family histone demethylase specific for H3-K36,similar to proteins found in human, mouse,drosophila, X. laevis, C. elegans, and S. pombe 0.005350.14468&radic&radic&radic&radic&radic S000003100YGL132WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C 0.005370.14468&radic&radic S000000203YBL107CUncharacterizedHypothetical protein 0.005350.14468&radic&radic&radic S000003716ATP12YJL180CverifiedConserved protein required for assembly of alpha and betasubunits into the F1 sector of mitochondrialF1F0 ATP synthase; mutation of human ATP12reduces active ATP synthase levels and isassociated with the disorder ATPAF2 deficiency 0.005330.14409&radic&radic&radic&radic S000000231YBR027CDubiousHypothetical protein 0.005330.14409&radic&radic S000004951LST8YNL006WverifiedProtein required for the transport of amino acid permease Gap1pfrom the Golgi to the cell surface; componentof the TOR signaling pathway; associates withboth Tor1p and Tor2p; contains a WD-repeat 0.005340.14409&radic S000005561SHE4YOR035CverifiedProtein containing a UCS (UNC-45/CRO1/SHE4) domain, binds tomyosin motor domains to regulate myosinfunction; involved in endocytosis, polarizationof the actin cytoskeleton, and asymmetric mRNAlocalization 0.005340.14409&radic&radic&radic&radic&radic&radic S000001127IPI1YHR085WverifiedProtein of unknown function, essential for viability, may beinvolved in rRNA processing 0.005340.14409&radic&radic&radic&radic S000001458MUC1YIR019CverifiedGPI-anchored cell surface glycoprotein required for diploidpseudohyphal formation and haploid invasivegrowth, transcriptionally regulated by the MAPKpathway (via Ste12p and Tec1p) and the cAMPpathway (via Flo8p) 0.005350.14409&radic&radic&radic&radic S000005141WHI3YNL197CverifiedRNA binding protein that sequesters CLN3 mRNA in cytoplasmicfoci; cytoplasmic retention factor for Cdc28pand associated cyclins; regulates cell fate anddose-dependently regulates the critical cellsize required for passage through Start 0.005320.14322&radic&radic&radic&radic&radic&radic S000005201SIP3YNL257CverifiedProtein that activates transcription through interaction withDNA-bound Snf1p, C-terminal region has aputative leucine zipper motif; potential Cdc28psubstrate 0.005310.14322&radic&radic&radic&radic&radic S000002741YDR333CUncharacterizedHypothetical protein 0.00530.14322&radic&radic&radic&radic&radic&radic S000003382YGR150CUncharacterizedPutative protein of unknown function; deletion mutant has growth defects on both non-fermentable carbon sources and rich medium; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; contains PPR motifs 0.005320.14322&radic&radic&radic&radic S000001055ARD1YHR013CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.00530.14322&radic&radic&radic&radic S000004732STO1YMR125WverifiedLarge subunit of the nuclear mRNA cap-binding protein complex,interacts with Npl3p to carry nuclear poly(A)+mRNA to cytoplasm; also involved in nuclearmRNA degradation and telomere maintenance;orthologous to mammalian CBP80 0.00530.14305&radic&radic&radic S000003081SLD3YGL113WverifiedProtein involved in the initiation of DNA replication, requiredfor proper assembly of replication proteins atthe origins of replication; interacts withCdc45p 0.005290.14244&radic&radic&radic&radic S000005999ATP4YPL078CverifiedSubunit b of the stator stalk of mitochondrial F1F0 ATPsynthase, which is a large, evolutionarilyconserved enzyme complex required for ATPsynthesis 0.005290.14244&radic&radic&radic&radic&radic&radic S000005791RBL2YOR265WverifiedProtein involved in microtubule morphogenesis, required forprotection from excess free beta-tubulin;proposed to be involved the folding ofbeta-tubulin 0.005280.14244&radic&radic&radic S000004108YLR118CVerifiedAcyl-protein thioesterase responsible for depalmitoylation of Gpa1p; the mutant has no gross defects in signaling through the mating pathway; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 0.005290.14244&radic&radic&radic S000002944STL1YDR536WverifiedGlycerol proton symporter of the plasma membrane, subject toglucose-induced inactivation, strongly buttransiently induced when cells are subjected toosmotic shock 0.005270.14244&radic&radic&radic&radic S000000668RSA4YCR072CverifiedWD-repeat protein involved in ribosome biogenesis; may interactwith ribosomes; required for maturation andefficient intra-nuclear transport or pre-60Sribosomal subunits, localizes to the nucleolus 0.005290.14244 S000004277YLR287CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene 0.005270.14244&radic&radic&radic&radic S000001902YFR006WUncharacterizedPutative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene 0.005270.14218&radic&radic S000004051RPL22AYLR061WverifiedProtein component of the large (60S) ribosomal subunit, hassimilarity to Rpl22Bp and to rat L22 ribosomalprotein 0.005270.14218&radic&radic&radic&radic S000001465YVH1YIR026CverifiedProtein phosphatase involved in vegetative growth at lowtemperatures, sporulation, and glycogenaccumulation; transcription induced by lowtemperature and nitrogen starvation; member ofthe dual-specificity family of proteinphosphatases 0.005270.14218&radic&radic&radic&radic&radic&radic&radic S000002542YCF1YDR135CverifiedVacuolar glutathione S-conjugate transporter of the ATP-bindingcassette family, has a role in detoxifyingmetals such as cadmium, mercury, and arsenite;also transports unconjugated bilirubin; similarto human cystic fibrosis protein CFTR 0.005260.14218&radic&radic&radic&radic S000001423YIL161WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene 0.005250.14178&radic&radic&radic S000001111RRP4YHR069CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp41p, Rrp42p,Rrp43p and Dis3p 0.005250.14178&radic&radic&radic&radic&radic&radic S000003504YGR272CUncharacterizedPutative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 0.005260.14178&radic&radic&radic&radic S000002475DOS2YDR068WverifiedProtein of unknown function, green fluorescent protein(GFP)-fusion protein localizes to the cytoplasm 0.005250.14178&radic&radic&radic&radic&radic S000004274ECI1YLR284CverifiedPeroxisomal delta3,delta2-enoyl-CoA isomerase, hexamericprotein that converts 3-hexenoyl-CoA totrans-2-hexenoyl-CoA, essential for thebeta-oxidation of unsaturated fatty acids,oleate-induced 0.005240.14162&radic&radic&radic&radic&radic S000000364CDC28YBR160WverifiedCatalytic subunit of the main cell cycle cyclin-dependentkinase (CDK); alternately associates with G1cyclins (CLNs) and G2/M cyclins (CLBs) whichdirect the CDK to specific substrates 0.005230.14141&radic&radic&radic&radic S000001087YHR045WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum 0.005230.14141&radic&radic S000004693YMR087WVerifiedPutative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain 0.005230.14141&radic&radic&radic S000002584UBC1YDR177WverifiedUbiquitin-conjugating enzyme that mediates selectivedegradation of short-lived and abnormalproteins; plays a role in vesicle biogenesisand ER-associated protein degradation (ERAD);component of the cellular stress response 0.005230.14141&radic&radic&radic&radic&radic S000004683CTF18YMR078CverifiedSubunit of a complex with Ctf8p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion; may have overlappingfunctions with Rad24p in the DNA damagereplication checkpoint 0.005220.14111&radic&radic&radic&radic S000003667YJL131CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria; YJL131C is a non-essential gene 0.005220.14111&radic&radic&radic&radic&radic S000004433RPS1AYLR441CverifiedRibosomal protein 10 (rp10) of the small (40S) subunit; nearlyidentical to Rps1Bp and has similarity to ratS3a ribosomal protein 0.005190.14033&radic&radic&radic&radic S000001345YIL083CUncharacterizedHomolog to human PPCS 0.005190.14033&radic&radic&radic&radic S000001550YNK1YKL067WverifiedNucleoside diphosphate kinase, catalyzes the transfer of gammaphosphates from nucleoside triphosphates,usually ATP, to nucleoside diphosphates by amechanism that involves formation of anautophosphorylated enzyme intermediate 0.005190.14033&radic&radic&radic&radic&radic&radic&radic S000005291LRO1YNR008WverifiedAcyltransferase that catalyzes diacylglycerol esterification;one of several acyltransferases that contributeto triglyceride synthesis; putative homolog ofhuman lecithin cholesterol acyltransferase 0.00520.14033&radic&radic&radic S000002491TVP23YDR084CuncharacterizedIntegral membrane protein localized to late Golgi vesiclesalong with the v-SNARE Tlg2p; green fluorescentprotein (GFP)-fusion protein localizes to thecytoplasm in a punctate pattern 0.005190.14033&radic&radic&radic&radic S000004629YMR027WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene 0.005180.13984&radic&radic&radic&radic&radic&radic S000004708YMR102CUncharacterizedProtein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene 0.005170.13984&radic S000000999STE20YHL007CverifiedSignal transducing kinase of the PAK (p21-activated kinase)family, involved in pheromone response andpseudohyphal/invasive growth pathways,activated by Cdc42p; binds Ste4p at a GBB motifpresent in noncatalytic domains of PAK kinases 0.005170.13984&radic&radic&radic&radic S000002808URH1YDR400WverifiedUridine nucleosidase (uridine-cytidine N-ribohydrolase),cleaves N-glycosidic bonds in nucleosides;involved in recycling pyrimidine deoxy- andribonucleosides via the pyrimidine salvagepathway 0.005180.13984&radic&radic&radic&radic S000004028COX12YLR038CverifiedSubunit VIb of cytochrome c oxidase, which is the terminalmember of the mitochondrial inner membraneelectron transport chain; required for assemblyof fully active cytochrome c oxidase but notrequired for activity after assembly 0.005170.13984&radic&radic&radic S000000077YAR029WUncharacterizedMember of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.005180.13984&radic&radic&radic&radic S000000210UGA2YBR006WverifiedSuccinate semialdehyde dehydrogenase involved in theutilization of gamma-aminobutyrate (GABA) as anitrogen source; part of the 4-aminobutyrateand glutamate degradation pathways; localizedto the cytoplasm 0.005170.13984&radic&radic&radic S000006256NHP6AYPR052CverifiedHigh-mobility group non-histone chromatin protein, functionallyredundant with Nhp6Bp; homologous to mammalianhigh mobility group proteins 1 and 2; acts torecruit transcription factor Rcs1p to certainpromoters 0.005160.13968&radic&radic&radic S000000382YBR178WDubiousHypothetical protein 0.005170.13968&radic&radic&radic&radic S000006391RPO26YPR187WverifiedRNA polymerase subunit ABC23, common to RNA polymerases I, II,and III; part of central core; similar tobacterial omega subunit 0.005150.13915&radic&radic&radic&radic&radic&radic&radic S000002656YDR248CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.005160.13915&radic&radic&radic&radic S000005457WRS1YOL097CverifiedCytoplasmic tryptophanyl-tRNA synthetase, aminoacylatestryptophanyl-tRNA 0.005150.13915&radic&radic&radic S000000346MAK5YBR142WverifiedEssential nucleolar protein, putative DEAD-box RNA helicaserequired for maintenance of M1 dsRNA virus;involved in biogenesis of large (60S) ribosomalsubunits 0.005150.13915&radic&radic&radic S000003047YGL079WUncharacterizedHypothetical protein 0.005150.13915&radic&radic&radic&radic S000005807PLP2YOR281CverifiedEssential protein with similarity to phosducins, which areGTPase inhibitors; lethality of null mutationis functionally complemented by expression ofmouse phosducin-like protein MgcPhLP 0.005160.13915&radic&radic S000000829GAL83YER027CverifiedOne of three possible beta-subunits of the Snf1 kinase complex,allows nuclear localization of the Snf1 kinasecomplex in the presence of a nonfermentablecarbon source; contains glycogen-binding domain 0.00510.13718&radic&radic&radic S000002680GLO2YDR272WverifiedCytoplasmic glyoxalase II, catalyzes the hydrolysis ofS-D-lactoylglutathione into glutathione andD-lactate 0.00510.13718&radic&radic&radic&radic S000002592ATC1YDR184CverifiedNuclear protein, possibly involved in regulation of cationstress responses and/or in the establishment ofbipolar budding pattern 0.005130.13718&radic&radic&radic&radic&radic&radic S000004847RNH1YMR234WverifiedRibonuclease H1, removes RNA primers during Okazaki fragmentsynthesis; degrades RNA attached to the 5'-endof a DNA strand 0.005110.13718&radic&radic&radic&radic&radic S000002506BMH2YDR099Wverified14-3-3 protein, minor isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others 0.005140.13718&radic&radic&radic&radic&radic&radic S000001652YKL169CDubiousHypothetical protein 0.005080.13718&radic&radic&radic&radic&radic&radic S000002936HLR1YDR528WverifiedProtein involved in regulation of cell wall composition andintegrity and response to osmotic stress;overproduction suppresses a lysis sensitive PKCmutation; similar to Lre1p, which functionsantagonistically to protein kinase A 0.005130.13718&radic&radic S000006359NCA2YPR155CverifiedProtein involved in regulation of mitochondrial expression ofsubunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1ATP synthase; functions with Nca3p 0.005120.13718&radic&radic&radic&radic&radic S000005073NRK1YNL129WverifiedNicotinamide riboside kinase, catalyzes the synthesis ofnicotinamide nucleotide (NMN) from nicotinamideriboside; involved in a salvage pathway forNAD+ biosynthesis 0.005080.13718&radic&radic&radic S000001901SAD1YFR005CverifiedConserved zinc-finger domain protein involved in pre-mRNAsplicing, required for assembly of U4 snRNAinto the U4/U6 particle 0.00510.13718&radic&radic&radic&radic&radic S000003606YJL070CUncharacterizedPutative protein of unknown function with similarity to AMP deaminases; YJL070C is a non-essential gene 0.005110.13718&radic&radic&radic&radic S000001029YHL037CDubiousHypothetical protein 0.005090.13718&radic&radic&radic&radic S000003326VAS1YGR094WverifiedMitochondrial and cytoplasmic valyl-tRNA synthetase 0.005140.13718&radic&radic&radic&radic&radic&radic S000006104YPL183CUncharacterizedHypothetical protein 0.005080.13718&radic S000003482YGR250CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.005120.13718&radic&radic&radic S000002294RDI1YDL135CverifiedRho GDP dissociation inhibitor involved in the localization andregulation of Cdc42p 0.00510.13718&radic&radic&radic&radic&radic S000001272DOT5YIL010WverifiedNuclear thiol peroxidase which functions as analkyl-hydroperoxide reductase duringpost-diauxic growth 0.005120.13718&radic&radic&radic S000005042RAS2YNL098CverifiedGTP-binding protein that regulates the nitrogen starvationresponse, sporulation, and filamentous growth;farnesylation and palmitoylation required foractivity and localization to plasma membrane;homolog of mammalian Ras proto-oncogenes 0.005110.13718&radic&radic S000000796DSF1YEL070WuncharacterizedDeletion suppressor of mpt5 mutation 0.005120.13718&radic S000000730YEA4YEL004WverifiedUridine diphosphate-N-acetylglucosamine (UDP-GlcNAc)transporter required for cell wall chitinsynthesis; localized to the ER 0.005130.13718&radic&radic&radic&radic S000000287TEC1YBR083WverifiedTranscription factor required for full Ty1 epxression,Ty1-mediated gene activation, and haploidinvasive and diploid pseudohyphal growth;TEA/ATTS DNA-binding domain family member 0.005090.13718&radic&radic&radic&radic&radic S000002930SPS2YDR522CverifiedProtein expressed during sporulation, redundant with Sps22p fororganization of the beta-glucan layer of thespore wall; S. pombe ortholog is a spore wallcomponent 0.005130.13718&radic&radic&radic S000003156YGL188CDubiousHypothetical protein 0.005120.13718&radic&radic&radic S000003622YJL086CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1 0.005120.13718&radic&radic S000000370TYR1YBR166CverifiedPrephenate dehydrogenase involved in tyrosine biosynthesis,expression is dependent on phenylalanine levels 0.005080.13718&radic&radic&radic S000000677SRB8YCR081WverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation; involved in glucoserepression 0.005070.13667&radic&radic&radic&radic S000003158CDC55YGL190CverifiedNon-essential regulatory subunit B of protein phosphatase 2A;has multiple roles in mitosis and proteinbiosynthesis; found in the nucleus of mostcells but also at the bud neck (large-buddedcells) and at the bud tip (small-budded cells) 0.005060.13667&radic&radic S000003633PHS1YJL097WuncharacterizedProtein of unknown function; homolog of mammalian PTPLA;involved in sphingolipid biosynthesis, proteintrafficking; required for cell viability 0.005060.13667&radic&radic S000005795PAC1YOR269WverifiedProtein involved in nuclear migration, part of thedynein/dynactin pathway; targets dynein tomicrotubule tips, which is necessary forsliding of microtubules along bud cortex;synthetic lethal with bni1; homolog of humanLIS1 0.005060.13667&radic&radic&radic S000003648MDV1YJL112WverifiedPeripheral protein of the cytosolic face of the mitochondrialouter membrane, required for mitochondrialfission; interacts with Fis1p and with thedynamin-related GTPase Dnm1p; contains WDrepeats 0.005060.13667 S000004807RPL36AYMR194WverifiedN-terminally acetylated protein component of the large (60S)ribosomal subunit, nearly identical to Rpl36Bpand has similarity to rat L36 ribosomalprotein; binds to 5.8 S rRNA 0.005070.13667&radic&radic&radic&radic&radic&radic&radic S000003308MRPL25YGR076CverifiedMitochondrial ribosomal protein of the large subunit 0.005060.13667&radic&radic&radic&radic S000004335GAS2YLR343WuncharacterizedPutative 1,3-beta-glucanosyltransferase, has similarity toGas1p 0.005070.13667&radic&radic&radic S000001924CDC14YFR028CverifiedProtein phosphatase required for mitotic exit; located in thenucleolus until liberated by the FEAR andMitotic Exit Network in anaphase, enabling itto act on key substrates to effect a decreasein CDK/B-cyclin activity and mitotic exit 0.005070.13667&radic&radic S000006357YPR153WUncharacterizedHypothetical protein 0.005080.13667&radic&radic&radic S000003439YGR207CVerifiedProtein of unknown function; homolog of mammalian electron transfer flavoprotein complex subunit ETF-beta; interacts with frataxin (Yfh1p) 0.005050.13624&radic&radic&radic&radic S000001314RPL34BYIL052CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl34Ap and has similarity to ratL34 ribosomal protein 0.005040.13624&radic&radic&radic S000000564KRR1YCL059CverifiedEssential nucleolar protein required for the synthesis of 18SrRNA and for the assembly of 40S ribosomalsubunit 0.005050.13624&radic&radic&radic&radic&radic&radic S000005356YNR073CUncharacterizedHypothetical protein 0.005050.13624&radic S000006356URN1YPR152CuncharacterizedPre-mRNA splicing factor associated with the U2-U5-U6 snRNPs,the RES complex, and the Prp19-associatedcomplex (NTC); null mutation displays syntheticgenetic interactions with mutations affectingU2 snRNA and pre-mRNA splicing factors 0.005050.13624&radic&radic S000001224SVP26YHR181WverifiedIntegral membrane protein of the early Golgi apparatus andendoplasmic reticulum, involved in COP IIvesicle transport; may also function to promoteretention of proteins in the early Golgicompartment 0.005040.13624&radic&radic&radic S000005690YOR164CVerifiedProtein of unknown function; interacts with Mdy2p 0.005020.13534&radic&radic&radic&radic&radic&radic&radic S000004627CSI1YMR025WverifiedSubunit of the Cop9 signalosome, which is required fordeneddylation, or removal of the ubiquitin-likeprotein Rub1p from Cdc53p (cullin); involved inadaptation to pheromone signaling 0.005040.13534&radic S000002782YDR374CUncharacterizedHypothetical protein 0.005030.13534&radic&radic&radic S000005208PDR17YNL264CverifiedPhosphatidylinositol transfer protein (PITP), downregulatesPlb1p-mediated turnover of phosphatidylcholine,found in the cytosol and microsomes, homologousto Pdr16p, deletion affects phospholipidcomposition 0.005020.13534&radic&radic&radic&radic&radic&radic S000000680TUP1YCR084CverifiedGeneral repressor of transcription, forms complex with Cyc8p,involved in the establishment of repressivechromatin structure through interactions withhistones H3 and H4, appears to enhanceexpression of some genes 0.005030.13534&radic S000005585YOR059CUncharacterizedHypothetical protein 0.005020.13534&radic&radic&radic&radic&radic S000003900HOM6YJR139CverifiedHomoserine dehydrogenase (L-homoserine:NADP oxidoreductase),dimeric enzyme that catalyzes the third step inthe common pathway for methionine and threoninebiosynthesis; enzyme has nucleotide-binding,dimerization and catalytic regions 0.005030.13534&radic&radic&radic&radic S000005157YNL213CUncharacterizedPutative protein of unknown function, contains a mitochondrial targeting sequence as identified by P-SORT; null mutant lacks mitochondrial DNA and cannot grow on glycerol 0.005020.13534&radic&radic&radic&radic&radic S000003109HUL5YGL141WverifiedProtein with similarity to hect domain E3 ubiquitin-proteinligases, not essential for viability 0.005030.13534&radic&radic&radic&radic S000003624ARG3YJL088WverifiedOrnithine carbamoyltransferase (carbamoylphosphate:L-ornithinecarbamoyltransferase), catalyzes the sixth stepin the biosynthesis of the arginine precursorornithine 0.005030.13534&radic&radic&radic&radic&radic S000003149GTS1YGL181WverifiedProtein containing a zinc-finger in the N-terminus and a longGln-rich region in the C-terminus; regulatesultradian rhythm, cell size, cell cycle,lifespan, sporulation, heat tolerance, andmultidrug transport 0.005010.13511&radic&radic S000003026RAD6YGL058WverifiedUbiquitin-conjugating enzyme (E2), involved in postreplicationrepair (with Rad18p), sporulation, telomeresilencing, and ubiquitin-mediated N-end ruleprotein degradation (with Ubr1p) 0.004990.13433&radic&radic&radic&radic&radic&radic S000004069SIC1YLR079WverifiedInhibitor of Cdc28-Clb kinase complexes that controls G1/Sphase transition, preventing premature S phaseand ensuring genomic integrity; phosphorylationtargets Sic1p for SCF(CDC4)-dependent turnover;functional homolog of mammalian Kip1 0.004990.13433&radic&radic&radic&radic S000001791DAD2YKR083CverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; is transferred to thekinetochore prior to mitosis 0.004990.13433&radic&radic&radic&radic S000006090MEX67YPL169CverifiedPoly(A)RNA binding protein involved in nuclear mRNA export,component of the nuclear pore; ortholog ofhuman TAP 0.0050.13433&radic&radic&radic S000003829RFC2YJR068WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon 0.0050.13433&radic&radic S000004023RSC58YLR033WverifiedRemodels the structure of chromatin complex 58KDa subunit;Chromatin Remodeling Complex subunit 0.004980.13424&radic&radic S000000264ORC2YBR060CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing; may be phosphorylated by Cdc28p 0.004980.13416&radic&radic&radic&radic&radic S000006260TFB4YPR056WverifiedSubunit of TFIIH complex, involved in transcription initiation,similar to 34 kDa subunit of human TFIIH;interacts with Ssl1p 0.004960.13329&radic&radic&radic S000005638CEX1YOR112WverifiedCytoplasmic component of the nuclear aminoacylation-dependenttRNA export pathway; interacts with nuclearpore component Nup116p; copurifies with tRNAexport receptors Los1p and Msn5p, as well aseIF-1a and the RAN GTPase Gsp1p 0.004950.13329&radic&radic&radic&radic S000005447YOL087CUncharacterizedHypothetical protein 0.004960.13329&radic&radic S000002989ALK1YGL021WverifiedProtein kinase; accumulation and phosphorylation are periodicduring the cell cycle; phosphorylated inresponse to DNA damage; contains characteristicmotifs for degradation via the APC pathway;similar to Alk2p and to mammalian haspins 0.004970.13329&radic&radic&radic S000000491ZSP1YBR287WuncharacterizedProtein of unknown function; mutation results in a zincsensitive phenotype 0.004960.13329&radic&radic S000000158YBL062WDubiousHypothetical protein 0.004960.13329&radic&radic&radic&radic&radic S000003093MET13YGL125WverifiedIsozyme of methylenetetrahydrofolate reductase, catalyzes thereduction of 5,10-methylenetetrahydrofolate to5-methyltetrahydrofolate in the methioninebiosynthesis pathway 0.004970.13329&radic&radic&radic&radic&radic S000005996GCR1YPL075WverifiedTranscriptional activator of genes involved in glycolysis;DNA-binding protein that interacts andfunctions with the transcriptional activatorGcr2p 0.004960.13329&radic&radic&radic&radic&radic&radic S000001360FMC1YIL098CverifiedMitochondrial matrix protein, required for assembly orstability at high temperature of the F1 sectorof mitochondrial F1F0 ATP synthase; null mutanttemperature sensitive growth on glycerol issuppressed by multicopy expression of Odc1p 0.004910.13197&radic&radic&radic S000002528DPB4YDR121WverifiedShared subunit of DNA polymerase epsilon and of ISW2/yCHRACchromatin accessibility complex; involved inboth chromosomal DNA replication and ininheritance of telomeric silencing 0.004920.13197&radic&radic&radic&radic&radic&radic&radic S000000368ARL1YBR164CverifiedSoluble GTPase with a role in regulation of membrane traffic;regulates potassium influx; G protein of theRas superfamily, similar to ADP-ribosylationfactor 0.004910.13197&radic&radic&radic S000003798YJR037WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; YJR037W is not an essential gene. 0.004940.13197&radic&radic&radic S000003775TMA22YJR014WverifiedProtein of unknown function that associates with ribosomes andhas a putative RNA binding domain; interactswith Tma20p; has homology to human proteinDRP1, which interacts with human Tma20p homologMCT-1 0.004930.13197&radic&radic&radic&radic S000004155PUS5YLR165CverifiedPseudouridine synthase, catalyzes only the formation ofpseudouridine (Psi)-2819 in mitochondrial 21SrRNA; not essential for viability 0.004920.13197&radic&radic&radic&radic&radic S000001172YHR130CDubiousHypothetical protein 0.004910.13197&radic&radic&radic&radic S000001333PCI8YIL071CverifiedPossible shared subunit of Cop9 signalosome (CSN) and eIF3,binds eIF3b subunit Prt1p, has possible dualfunctions in transcriptional and translationalcontrol, contains a PCI (Proteasome-COP9signalosome (CSN)-eIF3) domain 0.00490.13197&radic&radic&radic&radic&radic S000002379CDC13YDL220CverifiedSingle stranded DNA-binding protein found at TG1-3 telomereG-tails; regulates telomere replication throughrecruitment of specific sub-complexes, but theessential function is telomere capping 0.004910.13197&radic&radic&radic&radic S000005354YNR071CUncharacterizedHypothetical protein 0.004920.13197&radic&radic S000005260PHA2YNL316CverifiedPrephenate dehydratase, catalyzes the conversion of prephanateto phenylpyruvate, which is a step in thephenylalanine biosynthesis pathway 0.004930.13197&radic&radic S000001412MCM10YIL150CverifiedEssential, chromatin-associated protein involved in theinitiation of DNA replication; required for theassociation of the MCM2-7 complex withreplication origins 0.004920.13197&radic&radic&radic&radic S000002178RPN4YDL020CverifiedTranscription factor that stimulates expression of proteasomegenes; Rpn4p levels are in turn regulated bythe 26S proteasome in a negative feedbackcontrol mechanism; RPN4 is transcriptionallyregulated by various stress responses 0.00490.13197&radic&radic S000007472HUG1YML058W-AverifiedProtein involved in the Mec1p-mediated checkpoint pathway thatresponds to DNA damage or replication arrest,transcription is induced by DNA damage 0.004930.13197&radic&radic&radic S000000824SRB4YER022WverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation 0.004930.13197&radic&radic&radic&radic&radic&radic&radic&radic S000002633HTA1YDR225WverifiedOne of two nearly identical (see also HTA2) histone H2Asubtypes; core histone required for chromatinassembly and chromosome function; DNAdamage-dependent phosphorylation by Mec1pfacilitates DNA repair; acetylated by Nat4p 0.004910.13197&radic&radic&radic&radic S000005097GIM3YNL153CverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.004890.13141&radic&radic&radic S000000380ECM31YBR176WverifiedKetopantoate hydroxymethyltransferase, required for pantothenicacid biosynthesis, converts 2-oxoisovalerateinto 2-dehydropantoate 0.004890.13141&radic&radic&radic S000000208GPI18YBR004CverifiedFunctional ortholog of human PIG-V, which is amannosyltransferase that transfers the secondmannose in glycosylphosphatidylinositolbiosynthesis; the authentic, non-tagged proteinwas localized to mitochondria 0.004880.13141&radic&radic S000004053YLR063WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene 0.004880.13141&radic&radic&radic S000004137SMD3YLR147CverifiedCore Sm protein Sm D3; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D3 0.004890.13141&radic&radic&radic&radic&radic S000001103GIC1YHR061CverifiedProtein of unknown function involved in initiation of buddingand cellular polarization, interacts withCdc42p via the Cdc42/Rac-interactive binding(CRIB) domain 0.004890.13141&radic&radic&radic&radic S000001619YKL136WDubiousHypothetical protein 0.004890.13141&radic&radic&radic&radic&radic&radic&radic S000000359CNS1YBR155WverifiedTPR-containing co-chaperone; binds both Hsp82p (Hsp90) andSsa1p (Hsp70) and stimulates the ATPaseactivity of SSA1, ts mutants reduce Hsp82pfunction while over expression suppresses thephenotypes of an HSP82 ts allele and a cpr7deletion 0.004890.13141&radic&radic&radic S000000485DUG2YBR281CuncharacterizedProtein involved in alternative pathway of glutathionedegradation; green fluorescent protein(GFP)-fusion protein localizes to the cytoplasmand nucleus; YBR281C is not an essential gene 0.004880.13122&radic&radic&radic&radic&radic S000004668AEP1YMR064WverifiedProtein required for expression of the mitochondrial OLI1 geneencoding subunit 9 of F1-F0 ATP synthase 0.004870.13122&radic&radic&radic S000001608RRN3YKL125WverifiedProtein required for transcription of rDNA by RNA polymerase I;transcripti