Yfunc lets you browse current and predicted gene functions in yeast

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Prediction of GO:0016073 "snRNA metabolism"

GO branch: BP
Number of currently annotated genes: 8

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest TAP:129Ho:S000001341Ho:S000002334IPR002058PF03828Lee:GTS1PS01268Lum:TerbinafineLum:5-FCPR00939 S000005475PAP2YOL115WverifiedCatalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), anuclear poly (A) polymerase complex involved inRNA quality control; catalyzes polyadenylationof unmodified tRNAs, and snoRNA and rRNAprecursors; disputed role as a DNA polymerase &radic0.230790.97297&radic&radic S000005243TRF5YNL299WverifiedPoly (A) polymerase involved in nuclear RNA quality controlbased on: homology with Trf4p, geneticinteractions with TRF4 mutants, physicalinteraction with Mtr4p (TRAMP subunit), and bydirect assay; disputed role as a sigma DNApolymerase &radic0.08930.73576&radic&radic&radic&radic S000001341AIR1YIL079CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p to regulate methylationof Npl3p, which modulates Npl3p function inmRNA processing and export; has similarity toAir2p &radic0.053920.619&radic&radic&radic&radic S000004420YLR428CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1 0.037260.54776&radic S000002334AIR2YDL175CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p; may regulatemethylation of Npl3p, which modulates Npl3pfunction in mRNA processing and export; hassimilarity to Air1p &radic0.030970.52352&radic&radic&radic S000003586MTR4YJL050WverifiedDead-box family ATP dependent helicase required for mRNA exportfrom the nucleus; co-factor of the exosomecomplex, required for 3' end formation of 5.8SrRNA 0.022510.46741 S000002495SLU7YDR088CverifiedRNA splicing factor, required for ATP-independent portion of2nd catalytic step of spliceosomal RNAsplicing; interacts with Prp18p; contains zincknuckle domain 0.021070.44756&radic&radic&radic S000002840NPL3YDR432WverifiedRNA-binding protein that carries poly(A)+ mRNA from the nucleusinto the cytoplasm; phosphorylation by Sky1p inthe cytoplasm may promote release of mRNAs 0.019840.43592&radic&radic S000005527RRP6YOR001WverifiedExonuclease component of the nuclear exosome; contributes tothe quality-control system that retains anddegrades aberrant mRNAs in the nucleus 0.017060.41261&radic&radic S000005883YOR356WUncharacterizedHypothetical protein 0.014810.38415&radic S000006111NAB3YPL190CverifiedSingle stranded DNA binding protein; acidic ribonucleoprotein;required for termination of non-poly(A)transcripts and efficient splicing; interactswith Nrd1p 0.010470.33727&radic&radic&radic S000005195NRD1YNL251CverifiedRNA-binding protein that interacts with the C-terminal domainof the RNA polymerase II large subunit(Rpo21p), required for transcriptiontermination and 3' end maturation ofnonpolyadenylated RNAs 0.009980.33089&radic&radic S000004732STO1YMR125WverifiedLarge subunit of the nuclear mRNA cap-binding protein complex,interacts with Npl3p to carry nuclear poly(A)+mRNA to cytoplasm; also involved in nuclearmRNA degradation and telomere maintenance;orthologous to mammalian CBP80 0.009290.32202&radic S000000744EAF5YEL018WuncharacterizedEsa1p-associated factor, subunit of the NuA4 acetyltransferasecomplex 0.008940.32003&radic&radic S000001111RRP4YHR069CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp41p, Rrp42p,Rrp43p and Dis3p 0.008830.3174&radic S000005366TOP1YOL006CverifiedTopoisomerase I, nuclear enzyme that relieves torsional strainin DNA by cleaving and re-sealing thephosphodiester backbone; relaxes bothpositively and negatively supercoiled DNA;functions in replication, transcription, andrecombination 0.007170.28976 S000004852RNT1YMR239CverifiedRNAase III; cleaves a stem-loop structure at the 3' end of U2snRNA to ensure formation of the correct U2 3'end 0.006610.27339&radic&radic S000004265SMD2YLR275WverifiedCore Sm protein Sm D2; part of heteroheptameric complex (withSmb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D2 0.005860.25362&radic S000005381DIS3YOL021CverifiedNucleolar exosome component, involved in rRNA processing andRNA degradation, binds Gsp1p/Ran and enhancesthe GEF activity of Srm1p, implicated inmitotic control, homologous to the E. coliRNase R of the RNase II family 0.005780.25127&radic&radic S000003394TIF4631YGR162WverifiedTranslation initiation factor eIF4G, subunit of the mRNAcap-binding protein complex (eIF4F) that alsocontains eIF4E (Cdc33p); associates with thepoly(A)-binding protein Pab1p, also interactswith eIF4A (Tif1p); homologous to Tif4632p 0.00570.24762&radic S000005837NOP58YOR310CverifiedProtein involved in pre-rRNA processing, 18S rRNA synthesis,and snoRNA synthesis; component of the smallsubunit processome complex, which is requiredfor processing of pre-18S rRNA 0.005580.24379&radic S000004137SMD3YLR147CverifiedCore Sm protein Sm D3; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D3 0.005540.24236&radic S000001710PAP1YKR002WverifiedPoly(A) polymerase, one of three factors required for mRNA3'-end polyadenylation, forms multiproteincomplex with polyadenylation factor I (PF I),also required for mRNA nuclear export; may alsopolyadenylate rRNAs 0.005390.2353&radic&radic S000005176CSL4YNL232WverifiedSubunit of the exosome, which is an essential complex presentin both nucleus and cytoplasm that mediates RNAprocessing and degradation 0.004960.21933&radic&radic S000005199GIS2YNL255CverifiedProtein with seven cysteine-rich CCHC zinc-finger motifs,similar to human CNBP, proposed to be involvedin the RAS/cAMP signaling pathway 0.004770.21205&radic&radic S000005206POL2YNL262WverifiedCatalytic subunit of DNA polymerase epsilon, one of the majorchromosomal DNA replication polymerasescharacterized by processivity and proofreadingexonuclease activity; also involved in DNAsynthesis during DNA repair 0.004680.2077&radic S000004106MSL5YLR116WverifiedComponent of the commitment complex, which defines the firststep in the splicing pathway; essential proteinthat interacts with Mud2p and Prp40p, forming abridge between the intron ends; also involvedin nuclear retention of pre-mRNA 0.004620.20538&radic S000003490RAD2YGR258CverifiedSingle-stranded DNA endonuclease, cleaves single-stranded DNAduring nucleotide excision repair to excisedamaged DNA; subunit of Nucleotide ExcisionRepair Factor 3 (NEF3); homolog of human XPGprotein 0.003220.14878 S000003313SLX9YGR081CverifiedProtein of unknown function; deletion mutant has syntheticfitness defect with an sgs1 deletion mutant 0.00310.14478 S000002732UTP4YDR324CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.00290.1363 S000003335NOP7YGR103WverifiedNucleolar protein involved in rRNA processing and 60S ribosomalsubunit biogenesis; constituent of severaldifferent pre-ribosomal particles; required forexit from G0 and the initiation ofcell proliferation 0.002890.13609&radic S000004186PWP1YLR196WverifiedProtein with WD-40 repeats involved in rRNA processing;associates with trans-acting ribosomebiogenesis factors; similar to beta-transducinsuperfamily 0.002810.13228&radic S000000631RRP43YCR035CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp41p, Rrp42p,Rrp4p and Dis3p; required for efficientmaturation of 5.8S, 18S and 25S rRNA 0.002790.13146 S000000745MMS21YEL019CverifiedSUMO ligase involved in chromosomal organization and DNArepair; essential subunit of theMms21-Smc5-Smc6 complex; mutants are sensitiveto methyl methanesulfonate and show increasedspontaneous mutation and mitotic recombination 0.002730.12918&radic&radic S000002688RRP45YDR280WverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex 0.002720.12844&radic S000000682CSM1YCR086WverifiedNucleolar protein that forms a complex with Lrs4p which bindsMam1p at kinetochores during meiosis I tomediate accurate chromosome segregation, may beinvolved in premeiotic DNA replication;possible role in telomere maintenance 0.00270.12745 S000004842RRP5YMR229CverifiedProtein required for the synthesis of both 18S and 5.8S rRNA;C-terminal region is crucial for the formationof 18S rRNA and N-terminal region is requiredfor the 5.8S rRNA; component of small ribosomalsubunit (SSU) processosome 0.002670.12581 S000003088PRP43YGL120CverifiedRNA helicase in the DEAH-box family, functions in both RNApolymerase I and polymerase II transcriptmetabolism, involved in release of thelariat-intron from the spliceosome 0.002630.12266 S000004187SIK1YLR197WverifiedEssential evolutionarily-conserved nucleolar protein componentof the box C/D snoRNP complexes that direct2'-O-methylation of pre-rRNA during itsmaturation; overexpression causes spindleorientation defects 0.00260.12266 S000003327RRP46YGR095CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex 0.002590.12266&radic S000005337ESF2YNR054CverifiedEssential nucleolar protein involved in pre-18S rRNAprocessing; component of the small subunit(SSU) processome; has sequence similarity tomABT1, a mouse transcription activator 0.00260.12266 S000003931DRS1YLL008WverifiedNucleolar DEAD-box protein required for ribosome assembly andfunction, including synthesis of 60S ribosomalsubunits; constituent of 66S pre-ribosomalparticles 0.002540.12145 S000002256SNU23YDL098CverifiedComponent of U4/U6.U5 snRNP involved in mRNA splicing viaspliceosome 0.002510.11984&radic S000002140YAL064C-AUncharacterizedHypothetical protein 0.00250.11922&radic S000005442ATG19YOL082WverifiedProtein involved in the cytoplasm-to-vacuole targeting pathwayand in autophagy, recognizes cargo proteins anddelivers them to the preautophagosomalstructure for eventual engulfment by theautophagosome and degradation 0.00250.11922&radic&radic S000005287YNR004WUncharacterizedHypothetical protein 0.002490.11903 S000000939YER137CUncharacterizedHypothetical protein 0.002480.11879&radic S000002690YDR282CUncharacterizedHypothetical protein 0.002480.11822&radic S000002299RPO21YDL140CverifiedRNA polymerase II largest subunit B220, part of central core;phosphorylation of C-terminal heptapeptiderepeat domain regulates association withtranscription and splicing factors; similar tobacterial beta-prime 0.002480.11822 S000005732NOC2YOR206WverifiedProtein that forms a nucleolar complex with Mak21p that bindsto 90S and 66S pre-ribosomes, as well as anuclear complex with Noc3p that binds to 66Spre-ribosomes; both complexes mediateintranuclear transport of ribosomal precursors 0.00240.11538&radic&radic S000003802URB2YJR041CverifiedNucleolar protein required for normal metabolism of the rRNAprimary transcript, proposed to be involved inribosome biogenesis 0.002370.11437 S000004577ZDS2YML109WverifiedProtein that interacts with silencing proteins at the telomere,involved in transcriptional silencing; paralogof Zds1p 0.002350.11363 S000000238HMT1YBR034CverifiedNuclear SAM-dependent mono- and asymmetric argininedimethylating methyltransferase that modifieshnRNPs, including Npl3p and Hrp1p, thusfacilitating nuclear export of these proteins;required for viability of npl3 mutants 0.002340.11324 S000000831SMB1YER029CverifiedCore Sm protein Sm B; part of heteroheptameric complex (withSmd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm B and Sm B' 0.002310.11222 S000003992NOC3YLR002CverifiedProtein that forms a nuclear complex with Noc2p that binds to66S ribosomal precursors to mediate theirintranuclear transport; also binds to chromatinto promote the association of DNA replicationfactors and replication initiation 0.00230.1113&radic S000005502RRP40YOL142WverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex 0.00230.1113 S000006379DPB2YPR175WverifiedSecond largest subunit of DNA polymerase II (DNA polymeraseepsilon), required for normal yeast chromosomalreplication; expression peaks at the G1/S phaseboundary; potential Cdc28p substrate 0.002260.11008 S000001817YAL065CUncharacterizedHypothetical protein 0.002270.11008&radic&radic&radic S000000062SEO1YAL067CverifiedPutative permease, member of the allantoate transportersubfamily of the major facilitator superfamily;mutation confers resistance to ethioninesulfoxide 0.002210.10814&radic&radic S000002142PAU8YAL068CuncharacterizedHypothetical protein 0.00220.10804&radic&radic&radic S000005552BUB3YOR026WverifiedKinetochore checkpoint WD40 repeat protein that localizes tokinetochores during prophase and metaphase,delays anaphase in the presence of unattachedkinetochores; forms complexes with Mad1p-Bub1pand with Cdc20p, binds Mad2p and Mad3p 0.001920.09543&radic&radic S000005051YAF9YNL107WverifiedSubunit of both the NuA4 histone H4 acetyltransferase complexand the SWR1 complex, may function toantagonize silencing near telomeres; interactsdirectly with Swc4p, has homology to humanleukemogenic protein AF9, contains a YEATSdomain 0.001890.09432 S000001790NUP133YKR082WverifiedSubunit of the Nup84p subcomplex of the nuclear pore complex(NPC), localizes to both sides of the NPC,required to establish a normalnucleocytoplasmic concentration gradient of theGTPase Gsp1p 0.001880.09411 S000002360TRM8YDL201WverifiedSubunit of a tRNA methyltransferase complex composed of Trm8pand Trm82p that catalyzes 7-methylguanosinemodification of tRNA 0.001840.0924 S000001596RAD27YKL113Cverified5' to 3' exonuclease, 5' flap endonuclease, required forOkazaki fragment processing and maturation aswell as for long-patch base-excision repair;member of the S. pombe RAD2/FEN1 family 0.001830.092&radic&radic S000005056DBP2YNL112WverifiedEssential ATP-dependent RNA helicase of the DEAD-box proteinfamily, involved in nonsense-mediated mRNAdecay and rRNA processing 0.001810.09036 S000002847LRS4YDR439WverifiedProtein involved in rDNA silencing; positively chargedcoiled-coil protein with limited similarity tomyosin 0.001810.09036 S000003651ASF1YJL115WverifiedNucleosome assembly factor, involved in chromatin assembly anddisassembly, anti-silencing protein that causesderepression of silent loci when overexpressed 0.001810.09036 S000004520IMD4YML056CverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 0.001790.08975 S000001542MPE1YKL059CverifiedEssential conserved subunit of CPF (cleavage andpolyadenylation factor), plays a role in 3' endformation of mRNA via the specific cleavage andpolyadenylation of pre-mRNA, contains aputative RNA-binding zinc knuckle motif 0.001780.08874 S000004886ZDS1YMR273CverifiedProtein that interacts with silencing proteins at the telomere,involved in transcriptional silencing; has arole in localization of Bcy1p, a regulatorysubunit of protein kinase A; implicated in mRNAnuclear export 0.001750.0878&radic&radic S000006305SNT309YPR101WverifiedComponent of NineTeen complex (NTC) containing Prp19p involvedin mRNA splicing, interacts physically andgenetically with Prp19p 0.001720.08647 S000000120NCL1YBL024WverifiedS-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase,methylates cytosine to m5C at several positionsin tRNAs and intron-containing pre-tRNAs;similar to Nop2p and human proliferationassociated nucleolar protein p120 0.001730.08647 S000005730DED1YOR204WverifiedATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, requiredfor translation initiation of all yeast mRNAs;mutations in human DEAD-box DBY are a frequentcause of male infertility 0.001720.08647&radic S000001003PRS3YHL011Cverified5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involvedin nucleotide, histidine, and tryptophanbiosynthesis; one of a five related enzymes,which are active as heteromultimeric complexes 0.00170.08563 S000003095SOH1YGL127CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; involved in telomeremaintenance; conserved with other metazoanMED31 subunits 0.001710.08563 S000006311YTH1YPR107CverifiedEssential RNA-binding component of cleavage and polyadenylationfactor, contains five zinc fingers; requiredfor pre-mRNA 3'-end processing andpolyadenylation 0.001670.08391&radic&radic S000002447ENA1YDR040CverifiedP-type ATPase sodium pump, involved in Na+ and Li+ efflux toallow salt tolerance 0.001650.08329 S000004476TRM9YML014WverifiedtRNA methyltransferase, catalyzes the esterification ofmodified uridine nucleotides in tRNAs, creating5-methylcarbonylmethyluridine in tRNA(Arg3) and5-methylcarbonylmethyl-2-thiouridine intRNA(Glu); may have a role in stress response 0.001650.08296&radic&radic S000005372HTZ1YOL012CverifiedHistone variant H2AZ, exchanged for histone H2A in nucleosomesby the SWR1 complex; involved intranscriptional regulation through preventionof the spread of silent heterochromatin 0.001610.08025 S000004467ERG6YML008CverifiedDelta(24)-sterol C-methyltransferase, converts zymosterol tofecosterol in the ergosterol biosyntheticpathway by methylating position C-24; localizedto both lipid particles and mitochondrial outermembrane 0.001570.07857&radic S000005194RAD50YNL250WverifiedSubunit of MRX complex, with Mre11p and Xrs2p, involved inprocessing double-strand DNA breaks invegetative cells, initiation of meiotic DSBs,telomere maintenance, and nonhomologous endjoining 0.001550.07802 S000002648SNU56YDR240CverifiedComponent of U1 snRNP required for mRNA splicing viaspliceosome; yeast specific, no metazoancounterpart; interacts with mRNA in commitmentcomplex 0.001560.07802&radic S000004837MRE11YMR224CverifiedSubunit of a complex with Rad50p and Xrs2p (RMX complex) thatfunctions in repair of DNA double-strand breaksand in telomere stability, exhibits nucleaseactivity that appears to be required for RMXfunction; widely conserved 0.001520.07663&radic&radic S000000967PAB1YER165WverifiedPoly(A) binding protein, part of the 3'-end RNA-processingcomplex, mediates interactions between the 5'cap structure and the 3' mRNA poly(A) tail,involved in control of poly(A) tail length,interacts with translation factor eIF-4G 0.001520.07663 S000004312MMS22YLR320WverifiedProtein involved in resistance to ionizing radiation; acts withMms1p in a repair pathway that may be involvedin resolving replication intermediates orpreventing the damage caused by blockedreplication forks 0.001510.07646 S000005143GCR2YNL199CverifiedTranscriptional activator of genes involved in glycolysis;interacts and functions with the DNA-bindingprotein Gcr1p 0.001510.07624&radic S000005169CNM67YNL225CverifiedComponent of the spindle pole body outer plaque; required forspindle orientation and mitotic nuclearmigration 0.001460.07386&radic&radic S000001697YRA2YKL214CverifiedMember of the REF (RNA and export factor binding proteins)family; when overexpressed, can substitute forthe function of Yra1p in export of poly(A)+mRNA from the nucleus 0.001460.07361&radic&radic S000001323SNP1YIL061CverifiedComponent of U1 snRNP required for mRNA splicing viaspliceosome; may interact with poly(A)polymerase to regulate polyadenylation; homologof human U1 70K protein 0.001460.07361&radic S000005606DIA2YOR080WverifiedOrigin-binding F-box protein that forms an SCF ubiquitin ligasecomplex with Skp1p and Cdc53p; plays a role inDNA replication, involved in invasive andpseudohyphal growth 0.001450.07335&radic S000000455MRPS5YBR251WverifiedMitochondrial ribosomal protein of the small subunit 0.001450.07319&radic S000000787CIN8YEL061CverifiedKinesin motor protein involved in mitotic spindle assembly andchromosome segregation 0.001420.0721&radic&radic S000004029RIC1YLR039CverifiedProtein involved in retrograde transport to the cis-Golginetwork; forms heterodimer with Rgp1p that actsas a GTP exchange factor for Ypt6p; involved intranscription of rRNA and ribosomal proteingenes 0.001430.0721 S000000323MUD1YBR119WverifiedU1 snRNP A protein, homolog of human U1-A; involved in nuclearmRNA splicing 0.001430.0721&radic S000000063NUP60YAR002WverifiedSubunit of the nuclear pore complex (NPC), functions to anchorNup2p to the NPC in a process controlled by thenucleoplasmic concentration of Gsp1p-GTP;potential Cdc28p substrate; involved intelomere maintenance 0.001410.07128&radic&radic S000006365SGV1YPR161CverifiedCyclin (Bur2p)-dependent protein kinase that functions intranscriptional regulation; phosphorylates thecarboxy-terminal domain of Rpo21p, which is thelargest subunit of RNA polymerase II; regulatedby Cak1p 0.001370.06959&radic S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling 0.001350.06794&radic&radic S000005083RLR1YNL139CverifiedSubunit of the THO complex, which is required for efficienttranscription elongation and involved intranscriptional elongation-associatedrecombination; required for LacZ RNA expressionfrom certain plasmids 0.001350.06794&radic S000001897LOC1YFR001WverifiedNuclear protein involved in asymmetric localization of ASH1mRNA; binds double-stranded RNA in vitro;constituent of 66S pre-ribosomal particles 0.001340.06773&radic S000000542SRO9YCL037CverifiedCytoplasmic RNA-binding protein that associates withtranslating ribosomes; involved in hemeregulation of Hap1p as a component of the HMCcomplex, also involved in the organization ofactin filaments; contains a La motif 0.001330.06609&radic&radic S000006261BRR1YPR057WverifiedsnRNP protein component of spliceosomal snRNPs, required forpre-mRNA splicing and snRNP biogenesis; in nullmutant newly-synthesized snRNAs aredestabilized and 3'-end processing is slowed 0.00130.06523&radic S000004585NAB6YML117WuncharacterizedPutative RNA-binding protein, based on computational analysisof large-scale protein-protein interaction data 0.00130.06413&radic S000004216BUR2YLR226WverifiedCyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2pcomprise a CDK-cyclin complex involved intranscriptional regulation through itsphosphorylation of the carboxy-terminal domainof the largest subunit of RNA polymerase II 0.001270.0632&radic S000000818BIM1YER016WverifiedMicrotubule-binding protein that together with Kar9p makes upthe cortical microtubule capture site anddelays the exit from mitosis when the spindleis oriented abnormally 0.001270.0632&radic S000002517FOB1YDR110WverifiedNucleolar protein required for DNA replication fork blockingand recombinational hotspot activities; bindsto the replication fork barrier site in therDNA region; related to retroviral integrases 0.001250.06194&radic&radic S000000813TIR1YER011WverifiedCell wall mannoprotein of the Srp1p/Tip1p family ofserine-alanine-rich proteins; expression isdownregulated at acidic pH and induced by coldshock and anaerobiosis; abundance is increasedin cells cultured without shaking 0.001250.06194&radic&radic S000001495PRP40YKL012WverifiedU1 snRNP protein involved in splicing, interacts with thebranchpoint-binding protein during theformation of the second commitment complex 0.001220.06046&radic&radic S000004509PRP39YML046WverifiedU1 snRNP protein involved in splicing, contains multipletetriatricopeptide repeats 0.001230.06046&radic S000006099CBC2YPL178WverifiedSmall subunit of the heterodimeric cap binding complex thatalso contains Sto1p, component of thespliceosomal commitment complex; interacts withNpl3p, possibly to package mRNA for export fromthe nucleus; contains an RNA-binding motif 0.001210.05959&radic&radic S000003957RIX7YLL034CverifiedPutative ATPase of the AAA family, required for export ofpre-ribosomal large subunits from the nucleus;distributed between the nucleolus, nucleoplasm,and nuclear periphery depending on growthconditions 0.001210.05959&radic&radic S000003245SNU71YGR013WverifiedComponent of U1 snRNP required for mRNA splicing viaspliceosome; yeast specific, no metazoancounterpart 0.00120.05959&radic&radic S000003017TIF4632YGL049CverifiedTranslation initiation factor eIF4G, subunit of the mRNAcap-binding protein complex (eIF4F) that alsocontains eIF4E (Cdc33p); associates with thepoly(A)-binding protein Pab1p, also interactswith eIF4A (Tif1p); homologous to Tif4631p 0.001210.05959&radic&radic S000006132NIP7YPL211WverifiedNucleolar protein required for 60S ribosome subunit biogenesis,constituent of 66S pre-ribosomal particles;physically interacts with Nop8p and the exosomesubunit Rrp43p 0.001210.05959&radic&radic S000001128NAM8YHR086WverifiedRNA binding protein, component of the U1 snRNP protein; mutantsare defective in meiotic recombination and information of viable spores, involved in theformation of DSBs through meiosis-specificsplicing of MER2 pre-mRNA 0.00120.05899&radic&radic S000005923SNF8YPL002CverifiedComponent of the ESCRT-II complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; appears to be functionallyrelated to SNF7; involved in glucosederepression 0.001190.05836&radic S000003616SCP160YJL080CverifiedEssential RNA-binding G protein effector of mating responsepathway, predominantly associated with nuclearenvelope and ER, interacts in mRNA-dependentmanner with translating ribosomes via multipleKH domains, similar to vertebrate vigilins 0.001190.05836&radic S000004424IMD3YLR432WverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 0.001180.05802 S000006082BEM4YPL161CverifiedProtein involved in establishment of cell polarity and budemergence; interacts with the Rho1p smallGTP-binding protein and with the Rho-typeGTPase Cdc42p; involved in maintenance ofproper telomere length 0.001180.05802&radic S000002643PRP42YDR235WverifiedU1 snRNP protein involved in splicing, required for U1 snRNPbiogenesis; contains multipletetriatricopeptide repeats 0.001160.05642&radic&radic S000004949HRB1YNL004WverifiedPoly(A+) RNA-binding protein, involved in the export of mRNAsfrom the nucleus to the cytoplasm; similar toGbp2p and Npl3p 0.001150.05642 S000001927SMC2YFR031CverifiedComponent of the condensin complex, essential SMC chromosomalATPase family member that forms a complex withSmc4p to form the active ATPase; Smc2p/Smc4pcomplex binds DNA, possibly in the cleft formedby the coiled-coil of the folded dimer 0.001150.05642 S000004252YPT6YLR262CverifiedGTPase, Ras-like GTP binding protein involved in the secretorypathway, required for fusion ofendosome-derived vesicles with the late Golgi,maturation of the vacuolar carboxypeptidase Y;has similarity to the human GTPase, Rab6 0.001170.05642 S000003054MAD1YGL086WverifiedCoiled-coil protein involved in the spindle-assemblycheckpoint; phosphorylated by Mps1p uponcheckpoint activation which leads to inhibitionof the activity of the anaphase promotingcomplex; forms a complex with Mad2p 0.001170.05642 S000002245LUC7YDL087CverifiedEssential protein associated with the U1 snRNP complex;splicing factor involved in recognition of 5'splice site 0.001140.05577&radic S000000301VPS15YBR097WverifiedMyristoylated serine/threonine protein kinase involved invacuolar protein sorting; functions as amembrane-associated complex with Vps34p; activeform recruits Vps34p to the Golgi membrane;interacts with the GDP-bound form of Gpa1p 0.001140.05577 S000001891MSH4YFL003CverifiedProtein involved in meiotic recombination, required for normallevels of crossing over, colocalizes with Zip2pto discrete foci on meiotic chromosomes, hashomology to bacterial MutS protein 0.001150.05577&radic S000000284SEC18YBR080CverifiedATPase required for the release of Sec17p during the 'priming'step in homotypic vacuole fusion and for ER toGolgi transport; homolog of the mammalian NSF 0.001140.05512 S000004329VRP1YLR337CverifiedProline-rich actin-associated protein involved in cytoskeletalorganization and cytokinesis; related tomammalian Wiskott-Aldrich syndrome protein(WASP)-interacting protein (WIP) 0.001130.05466&radic S000000970CCA1YER168CverifiedATP (CTP):tRNA-specific tRNA nucleotidyltransferase; differentforms targeted to the nucleus, cytosol, andmitochondrion are generated via the use ofmultiple transcriptional and translationalstart sites 0.001120.05428 S000002545HPR1YDR138WverifiedSubunit of THO/TREX complexes that couple transcriptionelongation with mitotic recombination and withmRNA metabolism and export, subunit of an RNAPol II complex; regulates lifespan; involved intelomere maintenance; similar to Top1p 0.001110.05379&radic&radic S000005831ISW2YOR304WverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPasecomponent that, with Itc1p, forms a complexrequired for repression of a-specific genes,INO1, and early meiotic genes during mitoticgrowth 0.001110.05379&radic S000005187SLA2YNL243WverifiedTransmembrane actin-binding protein involved in membranecytoskeleton assembly and cell polarization;adaptor protein that links actin to clathrinand endocytosis; present in the actin corticalpatch of the emerging bud tip; dimer in vivo 0.00110.05326 S000003818CDC8YJR057WverifiedThymidylate and uridylate kinase, functions in de novobiosynthesis of pyrimidinedeoxyribonucleotides; converts dTMP to dTDP anddUMP to dUTP; essential for mitotic and meioticDNA replication; homologous to S. pombe Tmp1p 0.00110.05326 S000004093CDC45YLR103CverifiedDNA replication initiation factor; recruited to MCM pre-RCcomplexes at replication origins; promotesrelease of MCM from Mcm10p, recruits elongationmachinery; mutants in human homolog may causevelocardiofacial and DiGeorge syndromes 0.00110.05299&radic S000000435SWC5YBR231CuncharacterizedProtein of unknown function, component of the SWR1 complex,which exchanges histone variant H2AZ (Htz1p)for chromatin-bound histone H2A 0.001090.05277&radic S000000292POL30YBR088CverifiedProliferating cell nuclear antigen (PCNA), functions as thesliding clamp for DNA polymerase delta; mayfunction as a docking site for other proteinsrequired for mitotic and meiotic chromosomalDNA replication and for DNA repair 0.001080.05211 S000000913SWI4YER111CverifiedDNA binding component of the SBF complex (Swi4p-Swi6p), atranscriptional activator that in concert withMBF (Mbp1-Swi6p) regulates late G1-specifictranscription of targets including cyclins andgenes required for DNA synthesis and repair 0.001080.05196 S000003397MRPS35YGR165WverifiedMitochondrial ribosomal protein of the small subunit 0.001080.05196&radic S000005016RNH201YNL072WverifiedRibonuclease H2 catalytic subunit, removes RNA primers duringOkazaki fragment synthesis; cooperates withRad27p nuclease 0.001070.05162 S000001129YHR087WVerifiedProtein involved in RNA metabolism, one of two yeast homologs (with Sdo1p/Ylr022cp) of the human protein SBDS responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome, also conserved in Archaea 0.001070.05053 S000005530UTP23YOR004WverifiedEssential nucleolar protein that is a component of the SSU(small subunit) processome involved in 40Sribosomal subunit biogenesis; has homology toPINc domain protein Fcf1p, although the PINcdomain of Utp23p is not required for function 0.001060.05053&radic&radic S000000122LSM2YBL026WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.001060.05053 S000004683CTF18YMR078CverifiedSubunit of a complex with Ctf8p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion; may have overlappingfunctions with Rad24p in the DNA damagereplication checkpoint 0.001070.05053 S000003140NUP49YGL172WverifiedSubunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of thenuclear pore complex (NPC), required fornuclear export of ribosomes 0.001070.05053 S000002771ESC2YDR363WverifiedProtein involved in mating-type locus silencing, interacts withSir2p; probably functions to recruit orstabilize Sir proteins 0.001060.05053&radic S000002767VID21YDR359CverifiedComponent of the NuA4 histone acetyltransferase complex 0.001050.05041&radic S000003508RNH70YGR276Cverified3' exoribonuclease, required for 5S and tRNA-Arg3 maturation 0.001050.05019 S000004349RSC2YLR357WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; involvedin telomere maintenance 0.001050.05019 S000001886SMC1YFL008WverifiedSubunit of the multiprotein cohesin complex, essential proteininvolved in chromosome segregation and indouble-strand DNA break repair; SMC chromosomalATPase family member, binds DNA with apreference for DNA with secondary structure 0.001050.05019&radic&radic S000006395QCR2YPR191WverifiedSubunit 2 of the ubiquinol cytochrome-c reductase complex,which is a component of the mitochondrial innermembrane electron transport chain;transcription is regulated by Hap1p,Hap2p/Hap3p, and heme 0.001050.05019&radic&radic S000002544RGP1YDR137WverifiedSubunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) thatcatalyzes nucleotide exchange on Ypt6p 0.001050.05008&radic&radic S000004415ATG17YLR423CverifiedProtein that interacts with and is required for activation ofApg1p protein kinase; involved in autophagy butnot in the Cvt (cytoplasm to vacuole targeting)pathway 0.001050.05008 S000001132YNG2YHR090CverifiedSubunit of the NuA4 histone acetyltransferase complex thatacetylates histone H4 and H2A; has similarityto the human tumor suppressor ING1 0.001040.04973 S000004665RNA14YMR061WverifiedCleavage and polyadenylation factor I (CF I) component involvedin cleavage and polyadenylation of mRNA 3'ends; bridges interaction between Rna15p andHrp1p in the CF I complex 0.001040.04973 S000004045SPT8YLR055CverifiedSubunit of the SAGA transcriptional regulatory complex but notpresent in SAGA-like complex SLIK/SALSA,required for SAGA-mediated inhibition at somepromoters 0.001040.04972&radic S000002789YRA1YDR381WverifiedNuclear protein that binds to RNA and to Mex67p, required forexport of poly(A)+ mRNA from the nucleus;member of the REF (RNA and export factorbinding proteins) family; another familymember, Yra2p, can substitute for Yra1pfunction 0.001040.04972&radic&radic S000001725YKR017CUncharacterizedPutative protein of unknown function; contains a RING finger motif 0.001040.04972&radic S000005667ARP8YOR141CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes 0.001040.04972&radic S000004596RSC9YML127WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; DNA-binding protein involved inthe synthesis of rRNA and in transcriptionalrepression and activation of genes regulated bythe Target of Rapamycin (TOR) pathway 0.001030.04923 S000003510CWC22YGR278WverifiedEssential protein, component of a complex containing Cef1p, hassimilarity to S. pombe Cwf22p; putativespliceosomal component, based on computationalanalysis of large-scale protein-proteininteraction data 0.001030.04923 S000006072PRP46YPL151CverifiedSplicing factor that is found in the Cef1p subcomplex of thespliceosome 0.001030.04923&radic S000004181PEX13YLR191WverifiedIntegral peroxisomal membrane receptor for the PTS1 peroxisomalmatrix protein signal recognition factor Pex5p,required for the translocation of peroxisomalmatrix proteins, also interacts with Pex7p andPex14p, contains a C-terminal SH3 domain 0.001030.04923&radic S000000233CDS1YBR029CverifiedPhosphatidate cytidylyltransferase (CDP-diglyceridesynthetase); an enzyme that catalyzes thatconversion of CTP + phosphate into diphosphate+ CDP-diaclglyerol, a critical step in thesynthesis of all major yeast phospholipids 0.001030.04923 S000006161HSP82YPL240CverifiedCytoplasmic chaperone (Hsp90 family) required for pheromonesignaling and negative regulation of Hsf1p;docks with the mitochondrial import receptorTom70p for preprotein delivery; interacts withco-chaperones Cns1p, Cpr6p, Cpr7p, and Sti1p 0.001030.04873 S000003626DPB11YJL090CverifiedEssential BRCT repeat protein, required on the prereplicativecomplex at replication origins for loading DNApolymerases to initiate DNA synthesis, alsorequired for S/M checkpoint control 0.001020.04873 S000000322TEF2YBR118WverifiedTranslational elongation factor EF-1 alpha; also encoded byTEF1; functions in the binding reaction ofaminoacyl-tRNA (AA-tRNA) to ribosomes 0.001020.04873 S000002430SES1YDR023WverifiedCytosolic seryl-tRNA synthetase, class II aminoacyl-tRNAsynthetase that aminoacylates tRNA(Ser),displays tRNA-dependent amino acid recognitionwhich enhances discrimination of the serinesubstrate, interacts with peroxin Pex21p 0.001020.04873 S000003272KSS1YGR040WverifiedMitogen-activated protein kinase (MAPK) involved in signaltransduction pathways that control filamentousgrowth and pheromone response 0.001030.04873 S000003288RSC1YGR056WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; containstwo essential bromodomains, a bromo-adjacenthomology (BAH) domain, and an AT hook 0.001020.04869&radic S000004075ARP6YLR085CverifiedActin-related protein that binds nucleosomes; a component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.001020.04869&radic S000003390MTR3YGR158Cverified3'5' exoribonuclease, exosome subunit; nucleolar proteininvolved in export of mRNA and ribosomalsubunits; homologous to the E. coli exonucleaseRNase PH 0.001010.04843&radic S000002536SAC6YDR129CverifiedFimbrin, actin-bundling protein; cooperates with Scp1p(calponin/transgelin) in the organization andmaintenance of the actin cytoskeleton 0.001010.04843&radic S000001112TRM5YHR070WverifiedtRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacentto the anticodon that has a role in preventionof frameshifting; highly conserved acrossArchaea, Bacteria, and Eukarya 0.001020.04843&radic S000004925PSE1YMR308CverifiedKaryopherin/importin that interacts with the nuclear porecomplex; acts as the nuclear import receptorfor specific proteins, including Pdr1p, Yap1p,Ste12p, and Aft1p 0.001020.04843 S000004362ARC18YLR370CverifiedSubunit of the ARP2/3 complex, which is required for themotility and integrity of cortical actinpatches 0.001010.04654 S000005036YNL092WUncharacterizedPutative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene 0.001010.04654 S000003237TFG2YGR005CverifiedTFIIF (Transcription Factor II) middle subunit; involved inboth transcription initiation and elongation ofRNA polymerase II; homologous to human RAP30 0.001010.04654&radic S000000929LCP5YER127WverifiedEssential protein involved in maturation of 18S rRNA; depletionleads to inhibited pre-rRNA processing andreduced polysome levels; localizes primarily tothe nucleolus 0.001010.04654 S000005356YNR073CUncharacterizedHypothetical protein 0.001010.04616 S000004172SWI6YLR182WverifiedTranscription cofactor, forms complexes with DNA-bindingproteins Swi4p and Mbp1p to regulatetranscription at the G1/S transition; involvedin meiotic gene expression; localizationregulated by phosphorylation; potential Cdc28psubstrate 0.0010.04616 S000000770IES6YEL044WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.001010.04616&radic S000002160NHP10YDL002CverifiedProtein related to mammalian high mobility group proteins;likely component of the INO80 complex, which isan ATP-dependent chromatin-remodeling complex 0.0010.04616 S000003863VPS25YJR102CverifiedComponent of the ESCRT-II complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome 0.0010.04603 S000003062PAN2YGL094CverifiedEssential subunit of the Pan2p-Pan3p poly(A)-ribonucleasecomplex, which acts to control poly(A) taillength and regulate the stoichiometry andactivity of postreplication repair complexes 0.0010.045 S000006067NOP53YPL146CverifiedNucleolar protein; involved in biogenesis of the 60S subunit ofthe ribosome; interacts with rRNA processingfactors Cbf5p and Nop2p; null mutant is viablebut growth is severely impaired 0.0010.045 S000006284TEF1YPR080WverifiedTranslational elongation factor EF-1 alpha; also encoded byTEF2; functions in the binding reaction ofaminoacyl-tRNA (AA-tRNA) to ribosomes 0.000990.045 S000000422PYC2YBR218CverifiedPyruvate carboxylase isoform, cytoplasmic enzyme that convertspyruvate to oxaloacetate; highly similar toisoform Pyc1p but differentially regulated;mutations in the human homolog are associatedwith lactic acidosis 0.000980.045&radic&radic S000003201TAN1YGL232WverifiedPutative tRNA acetyltransferase, RNA-binding protein requiredfor the formation of the modified nucleosideN(4)-acetylcytidine in serine and leucine tRNAsbut not required for the same modification in18S rRNA 0.000980.045&radic&radic S000004494RAD52YML032CverifiedProtein that stimulates strand exchange by facilitating Rad51pbinding to single-stranded DNA; annealscomplementary single-stranded DNA; involved inthe repair of double-strand breaks in DNAduring vegetative growth and meiosis 0.000990.045&radic&radic S000005943RAD1YPL022WverifiedSingle-stranded DNA endonuclease (with Rad10p), cleavessingle-stranded DNA during nucleotide excisionrepair and double-strand break repair; subunitof Nucleotide Excision Repair Factor 1 (NEF1);homolog of human XPF protein 0.000990.045&radic S000002633HTA1YDR225WverifiedOne of two nearly identical (see also HTA2) histone H2Asubtypes; core histone required for chromatinassembly and chromosome function; DNAdamage-dependent phosphorylation by Mec1pfacilitates DNA repair; acetylated by Nat4p 0.0010.045&radic S000001238NVJ1YHR195WverifiedNuclear envelope protein that interacts with the vacuolarmembrane protein Vac8p to promote formation ofnucleus-vacuole junctions during piecemealmicroautophagy of the nucleus (PMN) 0.000980.045&radic S000001756NAP1YKR048CverifiedProtein that interacts with mitotic cyclin Clb2p; required forthe regulation of microtubule dynamics duringmitosis; controls bud morphogenesis; involvedin the transport of H2A and H2B histones to thenucleus 0.000980.04451&radic S000005133SRP1YNL189WverifiedKaryopherin alpha homolog, forms a dimer with karyopherin betaKap95p to mediate import of nuclear proteins,binds the nuclear localization signal of thesubstrate during import; may also play a rolein regulation of protein degradation 0.000980.04451&radic S000000602RVS161YCR009CverifiedAmphiphysin-like lipid raft protein; subunit of a complex(Rvs161p-Rvs167p) that regulates polarizationof the actin cytoskeleton, endocytosis, cellpolarity, cell fusion and viability followingstarvation or osmotic stress 0.000980.04451 S000000673PAT1YCR077CverifiedTopoisomerase II-associated deadenylation-dependentmRNA-decapping factor; also required forfaithful chromosome transmission, maintenanceof rDNA locus stability, and protection of mRNA3'-UTRs from trimming; functionally linked toPab1p 0.000980.04451 S000003783LSM8YJR022WverifiedLsm (Like Sm) protein; forms heteroheptameric complex (withLsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p)that is part of spliceosomal U6 snRNP and isalso implicated in processing of pre-tRNA,pre-snoRNA, and pre-rRNA 0.000970.04451 S000000968DNF1YER166WverifiedAminophospholipid translocase (flippase) that localizesprimarily to the plasma membrane; contributesto endocytosis, protein transport and cellpolarity; type 4 P-type ATPase 0.000970.04441 S000004918ADH2YMR303CverifiedGlucose-repressible alcohol dehydrogenase II, catalyzes theconversion of ethanol to acetaldehyde; involvedin the production of certain carboxylateesters; regulated by ADR1 0.000970.04441&radic S000004470SPT5YML010WverifiedProtein that forms a complex with Spt4p and mediates bothactivation and inhibition of transcriptionelongation; Spt4p-Spt5p complex also plays arole in pre-mRNA processing 0.000970.04441&radic S000005028END3YNL084CverifiedEH domain-containing protein involved in endocytosis, actincytoskeletal organization and cell wallmorphogenesis; forms a complex with Sla1p andPan1p 0.000970.04418 S000004682VPS20YMR077CverifiedMyristoylated subunit of ESCRTIII, the endosomal sortingcomplex required for transport of transmembraneproteins into the multivesicular body pathwayto the lysosomal/vacuolar lumen; cytoplasmicprotein recruited to endosomal membranes 0.000960.04383 S000006352YPR148CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.000960.04383&radic S000004984BDP1YNL039WverifiedEssential subunit of RNA polymerase III transcription factor(TFIIIB), which is involved in transcription ofgenes encoding tRNAs, 5S rRNA, U6 snRNA, andother small RNAs 0.000950.04318 S000003063VPS45YGL095CverifiedProtein of the Sec1p/Munc-18 family, essential for vacuolarprotein sorting; required for the function ofPep12p and the early endosome/late Golgi SNARETlg2p; essential for fusion of Golgi-derivedvesicles with the prevacuolar compartment 0.000950.04318 S000006005BRO1YPL084WverifiedCytoplasmic class E vacuolar protein sorting (VPS) factor thatcoordinates deubiquitination in themultivesicular body (MVB) pathway by recruitingDoa4p to endosomes 0.000950.04318 S000000935GLC7YER133WverifiedCatalytic subunit of type 1 serine/threonine proteinphosphatase, involved in many processesincluding glycogen metabolism, sporulation, andmitosis; interacts with multiple regulatorysubunits; predominantly isolated with Sds22p 0.000950.04318 S000000039CDC24YAL041WverifiedGuanine nucleotide exchange factor (GEF or GDP-release factor)for Cdc42p; required for polarity establishmentand maintenance, and mutants have morphologicaldefects in bud formation and shmooing 0.000940.04288&radic&radic S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.000940.04266&radic&radic S000005401NOP12YOL041CverifiedNucleolar protein, required for pre-25S rRNA processing;contains an RNA recognition motif (RRM) and hassimilarity to Nop13p, Nsr1p, and putativeorthologs in Drosophila and S. pombe 0.000930.04224&radic&radic S000004363ROM2YLR371WverifiedGDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutationsare synthetically lethal with mutations inrom1, which also encodes a GEP 0.000930.04224&radic&radic S000003306SMD1YGR074WverifiedCore Sm protein Sm D1; part of heteroheptameric complex (withSmb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D1 0.000930.04224&radic S000003660LSM1YJL124CverifiedLsm (Like Sm) protein; forms heteroheptameric complex (withLsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p)involved in degradation of cytoplasmic mRNAs 0.000930.04224 S000005925LSP1YPL004CverifiedPrimary component of eisosomes, which are large immobile patchstructures at the cell cortex associated withendocytosis, along with Pil1p and Sur7p ; nullmutants show activation of Pkc1p/Ypk1p stressresistance pathways 0.000930.04224 S000000483PAF1YBR279WverifiedRNA polymerase II-associated protein, defines a large complexthat is biochemically and functionally distinctfrom the Srb-Mediator form of Pol II holoenzymeand is required for full expression of a subsetof cell cycle-regulated genes 0.000930.04224 S000001906UBP6YFR010WverifiedUbiquitin-specific protease situated in the base subcomplex ofthe 26S proteasome, releases free ubiquitinfrom branched polyubiquitin chains; deletioncauses hypersensitivity to cycloheximide andother toxic compounds 0.000930.04224&radic S000002419RPL4BYDR012WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl4Ap and has similarity to E.coli L4 and rat L4 ribosomal proteins 0.000920.04181 S000004409VPS36YLR417WverifiedComponent of the ESCRT-II complex; contains the GLUE (GRAM LikeUbiquitin binding in EAP45) domain which isinvolved in interactions with ESCRT-I andubiquitin-dependent sorting of proteins intothe endosome 0.000910.04156&radic S000002718SUM1YDR310CverifiedTranscriptional repressor required for mitotic repression ofmiddle sporulation-specific genes; involved intelomere maintenance, regulated by thepachytene checkpoint 0.000920.04156 S000000996MRP4YHL004WverifiedMitochondrial ribosomal protein of the small subunit 0.00090.0411 S000004339KAP95YLR347CverifiedKaryopherin beta, forms a dimeric complex with Srp1p (Kap60p)that mediates nuclear import of cargo proteinsvia a nuclear localization signal (NLS),interacts with nucleoporins to guide transportacross the nuclear pore complex 0.00090.0411&radic&radic&radic S000000286UBC4YBR082CverifiedUbiquitin-conjugating enzyme that mediates degradation ofshort-lived and abnormal proteins; interactswith E3-CaM in ubiquitinating calmodulin;interacts with many SCF ubiquitin proteinligases; component of the cellular stressresponse 0.00090.04097 S000001123LRP1YHR081WverifiedSubstrate-specific nuclear cofactor for exosome activity in theprocessing of stable RNAs; required fortelomere length maintenance; homolog ofmammalian nuclear matrix protein C1D involvedin regulation of DNA repair and recombination &radic0.00090.04097&radic&radic S000001508PAN3YKL025CverifiedEssential subunit of the Pan2p-Pan3p poly(A)-ribonucleasecomplex, which acts to control poly(A) taillength and regulate the stoichiometry andactivity of postreplication repair complexes 0.00090.04093&radic S000004513RSE1YML049CverifiedProtein involved in pre-mRNA splicing; component of thepre-spliceosome; associates with U2 snRNA;involved in ER to Golgi transport 0.00090.04093&radic S000002572TRM82YDR165WverifiedSubunit of a tRNA methyltransferase complex composed of Trm8pand Trm82p that catalyzes 7-methylguanosinemodification of tRNA 0.000890.04054&radic S000004597MSC1YML128CverifiedProtein of unknown function; mutant is defective in directingmeiotic recombination events to homologouschromatids; the authentic, non-tagged proteinis detected in highly purified mitochondria inhigh-throughput studies 0.000890.04054 S000006177CLN2YPL256CverifiedG1 cyclin involved in regulation of the cell cycle; activatesCdc28p kinase to promote the G1 to S phasetransition; late G1 specific expression dependson transcription factor complexes, MBF(Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) 0.000890.04039&radic&radic S000001234CTF8YHR191CverifiedSubunit of a complex with Ctf18p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion 0.000890.04039 S000003406CBP4YGR174CverifiedMitochondrial protein required for assembly of ubiquinolcytochrome-c reductase complex (cytochrome bc1complex); interacts with Cbp3p and function ispartially redundant with that of Cbp3p 0.000870.03983&radic&radic S000001732DBP7YKR024CverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in ribosomal biogenesis 0.000860.03951&radic S000004882TMA23YMR269WverifiedProtein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to thenucleolus; identified in proteomic screens ofribosomal complexes; YMR269W is not anessential gene 0.000860.03951&radic S000005307YNR024WUncharacterizedHypothetical protein 0.000860.03938 S000003797HUL4YJR036CverifiedProtein with similarity to hect domain E3 ubiquitin-proteinligases, not essential for viability 0.000850.03923 S000004844PEP5YMR231WverifiedPeripheral vacuolar membrane protein required for proteintrafficking and vacuole biogenesis; formscomplex with Pep3p that promotes vesiculardocking/fusion reactions in conjunction withSNARE proteins, also interacts with Pep7p 0.000850.03923&radic&radic S000002581HMO1YDR174WverifiedChromatin associated high mobility group (HMG) family memberinvolved in genome maintenance; rDNA-bindingcomponent of the Pol I transcription system;associates with a 5'-3' DNA helicase and Fpr1p,a prolyl isomerase 0.000840.0381 S000000514STP22YCL008CverifiedComponent of the ESCRT-I complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; homologous to the mouse and humanTsg101 tumor susceptibility gene; mutantsexhibit a Class E Vps phenotype 0.000840.0381 S000006074RAD53YPL153CverifiedProtein kinase, required for cell-cycle arrest in response toDNA damage; activated by transautophosphorylation when interacting withhyperphosphorylated Rad9p; also interacts withARS1 and plays a role in initiation of DNAreplication 0.000840.0381&radic&radic S000003121PEX14YGL153WverifiedPeroxisomal membrane protein that is a central component of theperoxisomal protein import machinery, interactswith PTS1 (Pex5p) and PTS2 (Pex7p) peroxisomalmatrix protein signal recognition factors andmembrane receptor Pex13p 0.000830.038 S000002905ITR1YDR497CverifiedMyo-inositol transporter with strong similarity to the minormyo-inositol transporter Itr2p, member of thesugar transporter superfamily; expression isrepressed by inositol and choline via Opi1p andderepressed via Ino2p and Ino4p 0.000820.03767 S000003719MNN11YJL183WverifiedSubunit of a Golgi mannosyltransferase complex that alsocontains Anp1p, Mnn9p, Mnn10p, and Hoc1p, andmediates elongation of the polysaccharidemannan backbone; has homology to Mnn10p 0.000810.03719&radic&radic S000003746PEX2YJL210WverifiedRING-finger peroxin, peroxisomal membrane protein with aC-terminal zinc-binding RING domain, formsputative translocation subcomplex with Pex10pand Pex12p which functions in peroxisomalmatrix protein import 0.00080.03706&radic&radic S000003391NSR1YGR159CverifiedNucleolar protein that binds nuclear localization sequences,required for pre-rRNA processing and ribosomebiogenesis 0.00080.03639&radic&radic S000005192RPA49YNL248CverifiedRNA polymerase I subunit A49 0.00080.03639 S000001073RRM3YHR031CverifiedDNA helicase involved in rDNA replication and Ty1transposition; relieves replication fork pausesat telomeric regions; structurally andfunctionally related to Pif1p 0.000770.03565&radic S000004616BUD22YMR014WverifiedProtein involved in bud-site selection; diploid mutants displaya random budding pattern instead of thewild-type bipolar pattern 0.000770.03536 S000004138PEP3YLR148WverifiedVacuolar peripheral membrane protein that promotes vesiculardocking/fusion reactions in conjunction withSNARE proteins, required for vacuolarbiogenesis, forms complex with Pep5p thatmediates protein transport to the vacuole 0.000760.03507 S000005821UAF30YOR295WverifiedSubunit of UAF (upstream activation factor), which is an RNApolymerase I specific transcription stimulatoryfactor composed of Uaf30p, Rrn5p, Rrn9p,Rrn10p, histones H3 and H4; deletion decreasescellular growth rate 0.000750.03483&radic S000002467MAK21YDR060WverifiedConstituent of 66S pre-ribosomal particles, required for large(60S) ribosomal subunit biogenesis; involved innuclear export of pre-ribosomes; required formaintenance of dsRNA virus; homolog of humanCAATT-binding protein 0.000710.03347&radic S000005604BUD21YOR078WverifiedComponent of small ribosomal subunit (SSU) processosome thatcontains U3 snoRNA; originally isolated asbud-site selection mutant that displays arandom budding pattern 0.000710.03329&radic S000005819RPS10AYOR293WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps10Bp and has similarity to ratribosomal protein S10 0.000710.03329 S000001497URB1YKL014CverifiedNucleolar protein required for the normal accumulation of 25Sand 5.8S rRNAs, associated with the 27SA2pre-ribosomal particle; proposed to be involvedin the biogenesis of the 60S ribosomal subunit 0.000710.03323&radic S000005736RPB10YOR210WverifiedRNA polymerase subunit ABC10-beta, common to RNA polymerases I,II, and III 0.000680.03188&radic S000004806MRPL24YMR193WverifiedMitochondrial ribosomal protein of the large subunit 0.000670.03156&radic S000004328SGD1YLR336CverifiedEssential nuclear protein with a possible role in theosmoregulatory glycerol response; interactswith phospholipase C (Plc1p); putative homologof human NOM1 which is implicated in acutemyeloid leukemia 0.000660.03142&radic S000006314RPC40YPR110CverifiedRNA polymerase subunit, common to RNA polymerase I and III 0.000660.03128&radic S000006373JIP5YPR169WuncharacterizedNucleolar protein of unknown function, exhibits a physicalinteraction with Bre1p 0.000660.03109 S000005005NOP2YNL061WverifiedProbable RNA m(5)C methyltransferase, essential for processingand maturation of 27S pre-rRNA and largeribosomal subunit biogenesis; localized to thenucleolus; constituent of 66S pre-ribosomalparticles 0.000650.03097 S000002494RRP1YDR087CverifiedEssential evolutionarily conserved nucleolar protein necessaryfor biogenesis of 60S ribosomal subunits andprocessing of pre-rRNAs to mature rRNAs,associated with several distinct 66Spre-ribosomal particles 0.000650.03083&radic S000001185RPC10YHR143W-AverifiedRNA polymerase subunit, found in RNA polymerase complexes I,II, and III 0.000650.03074 S000005370RCL1YOL010WverifiedRNA terminal phosphate cyclase-like protein involved in rRNAprocessing at sites A0, A1, and A2; does notpossess detectable RNA cyclase activity 0.000640.03066&radic S000006341RRP9YPR137WverifiedProtein involved in pre-rRNA processing, associated with U3snRNP; component of small ribosomal subunit(SSU) processosome; ortholog of the humanU3-55k protein 0.000640.03043 S000002733YCG1YDR325WverifiedNon-SMC subunit of the condensin complex(Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required forestablishment and maintenance of chromosomecondensation, chromosome segregation and forchromatin binding of the condensin complex 0.000640.03043 S000003512PXR1YGR280CverifiedEssential protein involved in rRNA and snoRNA maturation;competes with TLC1 RNA for binding to Est2p,suggesting a role in regulation of telomerase;human homolog inhibits telomerase; contains aG-patch RNA interacting domain 0.000630.0304 S000004883RRN9YMR270CverifiedProtein involved in promoting high level transcription of rDNA,subunit of UAF (upstream activation factor) forRNA polymerase I 0.000640.0304&radic S000003605UTP18YJL069CuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.000630.03022 S000001389YIL127CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus 0.000630.03004 S000003046DBP3YGL078CverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in ribosomal biogenesis 0.000630.03004&radic&radic S000001239UTP9YHR196WverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.000630.03004&radic S000004359RPS22BYLR367WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps22Ap and has similarity to E.coli S8 and rat S15a ribosomal proteins 0.000620.02986&radic S000004728RPL15BYMR121CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl15Ap and has similarity to ratL15 ribosomal protein; binds to 5.8 S rRNA 0.000610.02946 S000002806UTP5YDR398WverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.000610.02937&radic S000005119NOP13YNL175CverifiedProtein of unknown function, localizes to the nucleolus andnucleoplasm; contains an RNA recognition motif(RRM) and has similarity to Nop12p, which isrequired for processing of pre-18S rRNA 0.00060.02921&radic S000004212UTP13YLR222CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.00060.02892 S000005252KRI1YNL308CverifiedEssential nucleolar protein required for 40S ribosomebiogenesis; physically and functionallyinteracts with Krr1p 0.00060.02892 S000005868RPA190YOR341WverifiedRNA polymerase I subunit; largest subunit of RNA polymerase I 0.00060.02892 S000001800SRP40YKR092CverifiedNucleolar, serine-rich protein with a role in preribosomeassembly or transport; may function as achaperone of small nucleolar ribonucleoproteinparticles (snoRNPs); immunologically andstructurally to rat Nopp140 0.00060.02892 S000004652ERB1YMR049CverifiedProtein required for maturation of the 25S and 5.8S ribosomalRNAs; constituent of 66S pre-ribosomalparticles; homologous to mammalian Bop1 0.000590.02883 S000003562RRN7YJL025WverifiedProtein involved in the transcription of 35S rRNA genes by RNApolymerase I; component of the core factor (CF)complex also composed of Rrn11p, Rrn6p andTATA-binding protein 0.000590.02875 S000002865TOM1YDR457WverifiedE3 ubiquitin ligase of the hect-domain class; has a role inmRNA export from the nucleus and may regulatetranscriptional coactivators 0.000590.02863 S000005440REX4YOL080CverifiedPutative RNA exonuclease possibly involved in pre-rRNAprocessing and ribosome assembly 0.000590.02863 S000000609YCR016WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; YCR016W is not an essential gene 0.000590.02863 S000004699UTP15YMR093WverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.000590.02863 S000002433YDR026CUncharacterizedPutative transcription factor; Myb-like DNA-binding protein that may bind to the Ter region of rDNA; interacts physically with Fob1p, although this interaction is not involved in replication fork arrest 0.000590.02841 S000006214RPA135YPR010CverifiedRNA polymerase I subunit A135 0.000590.02841 S000002563RPA14YDR156WverifiedRNA polymerase I subunit A14 0.000590.02841&radic S000001504MAK11YKL021CverifiedProtein essential for cell growth and replication of M dsRNAvirus; contains four beta-transducin repeats 0.000590.02841&radic S000002904PUF6YDR496CverifiedPumilio-homology domain protein that binds ASH1 mRNA at PUFconsensus sequences in the 3' UTR and repressesits translation, resulting in proper asymmetriclocalization of ASH1 mRNA 0.000590.02841 S000004131RRN5YLR141WverifiedProtein involved in transcription of rDNA by RNA polymerase I;transcription factor, member of UAF (upstreamactivation factor) family along with Rrn9p andRrn10p 0.000580.02725 S000004165CBF5YLR175WverifiedPseudouridine synthase catalytic subunit of box H/ACA smallnucleolar ribonucleoprotein particles(snoRNPs), acts on both large and small rRNAsand on snRNA U2 0.000580.02725 S000002428FAL1YDR021WverifiedNucleolar protein required for maturation of 18S rRNA, memberof the eIF4A subfamily of DEAD-boxATP-dependent RNA helicases 0.000570.02724 S000001212DBP8YHR169WverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in biogenesis of the 40S ribosomalsubunit 0.000570.02717 S000001894SPB4YFL002CverifiedPutative ATP-dependent RNA helicase, nucleolar protein requiredfor synthesis of 60S ribosomal subunits at alate step in the pathway; sediments with 66Spre-ribosomes in sucrose gradients 0.000570.02717 S000000121RRN10YBL025WverifiedProtein involved in promoting high level transcription of rDNA,subunit of UAF (upstream activation factor) forRNA polymerase I 0.000570.02708&radic S000003570HCA4YJL033WverifiedPutative nucleolar DEAD box RNA helicase; high-copy numbersuppression of a U14 snoRNA processing mutantsuggests an involvement in 18S rRNA synthesis 0.000570.02708 S000001561DHR2YKL078WverifiedPredominantly nucleolar DEAH-box RNA helicase, required for 18SrRNA synthesis 0.000560.02682&radic S000003360UTP8YGR128CverifiedNucleolar protein required for export of tRNAs from thenucleus; also copurifies with the small subunit(SSU) processome containing the U3 snoRNA thatis involved in processing of pre-18S rRNA 0.000560.02682 S000001358YIL096CUncharacterizedPutative protein of unknown function; associates with precursors of the 60S ribosomal subunit 0.000560.02682&radic S000004441FPR4YLR449WverifiedPeptidyl-prolyl cis-trans isomerase (PPIase) (prolineisomerase) localized to the nucleus; catalyzesisomerization of proline residues in histonesH3 and H4, which affects lysine methylation ofthose histones 0.000560.02682 S000002367NHP2YDL208WverifiedNuclear protein related to mammalian high mobility group (HMG)proteins, essential for function of H/ACA-typesnoRNPs, which are involved in 18S rRNAprocessing 0.000560.02682 S000003079NSA1YGL111WverifiedConstituent of 66S pre-ribosomal particles, involved in 60Sribosomal subunit biogenesis 0.000560.02682 S000001768UTP30YKR060WuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.000560.02682&radic S000004211RSA3YLR221CverifiedProtein with a likely role in ribosomal maturation, requiredfor accumulation of wild-type levels of large(60S) ribosomal subunits; binds to the helicaseDbp6p in pre-60S ribosomal particles in thenucleolus 0.000560.02682&radic&radic S000002820RRP17YDR412WuncharacterizedProtein required for cell viability 0.000560.02682&radic S000003684RPA34YJL148WverifiedRNA polymerase I subunit A34.5 0.000560.02681&radic S000006047NAN1YPL126WverifiedU3 snoRNP protein, component of the small (ribosomal) subunit(SSU) processosome containing U3 snoRNA;required for the biogenesis of18S rRNA 0.000560.02659&radic S000001094CIC1YHR052WverifiedEssential protein that interacts with proteasome components andhas a potential role in proteasome substratespecificity; also copurifies with 66Spre-ribosomal particles 0.000560.02659 S000003547NOP9YJL010CuncharacterizedEssential nucleolar protein required for 18S rRNA synthesis 0.000560.02659 S000005504NOP8YOL144WverifiedNucleolar protein required for 60S ribosomal subunit biogenesis 0.000550.0265 S000005057RPC19YNL113WverifiedRNA polymerase subunit, common to RNA polymerases I and III 0.000550.0265 S000002707BFR2YDR299WverifiedEssential protein possibly involved in secretion; multicopysuppressor of sensitivity to Brefeldin A 0.000550.0265&radic S000000536RRP7YCL031CverifiedEssential protein involved in rRNA processing and ribosomebiogenesis 0.000540.02625 S000006119RPL7BYPL198WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl7Ap and has similarity to E.coli L30 and rat L7 ribosomal proteins;contains a conserved C-terminal Nucleic acidBinding Domain (NDB2) 0.000540.02625&radic&radic S000001492MRT4YKL009WverifiedProtein involved in mRNA turnover and ribosome assembly,localizes to the nucleolus 0.000550.02625 S000004846YMR233WUncharacterizedProtein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; YMR233W is not an essential gene 0.000540.02625&radic&radic S000003645UTP10YJL109CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.000540.0261 S000001718TOF2YKR010CverifiedNonessential mitochondrial protein of unknown function withsequence similarity to Net1p; identified as atopoisomerase I (Top1p) binding protein;displays synthetic genetic interactions withTOP1 and HPR1 0.000540.0261 S000000564KRR1YCL059CverifiedEssential nucleolar protein required for the synthesis of 18SrRNA and for the assembly of 40S ribosomalsubunit 0.000540.02598&radic S000002773ESF1YDR365CverifiedNucleolar protein involved in pre-rRNA processing; depletioncauses severely decreased 18S rRNA levels 0.000540.02598&radic&radic S000000345YBR141CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene 0.000540.02598 S000003727RPS14BYJL191WverifiedRibosomal protein 59 of the small subunit, required forribosome assembly and 20S pre-rRNA processing;mutations confer cryptopleurine resistance;nearly identical to Rps14Ap and similar to E.coli S11 and rat S14 ribosomal proteins 0.000530.02579 S000003515YGR283CUncharacterizedPutative protein of unknown function; deletion mutant is resistant to fluconazole; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus 0.000530.02566&radic S000002720SSF2YDR312WverifiedProtein required for ribosomal large subunit maturation,functionally redundant with Ssf1p; member ofthe Brix family 0.000530.02566&radic S000004735ECM16YMR128WverifiedEssential DEAH-box ATP-dependent RNA helicase specific to theU3 snoRNP, predominantly nucleolar indistribution, required for 18S rRNA synthesis 0.000530.02566 S000004967YNL022CUncharacterizedPutative protein of unknown function with seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to a single spot in the nucleus; YNL022C is not an essential gene 0.000530.02566 S000005054NOP15YNL110CverifiedConstituent of 66S pre-ribosomal particles, involved in 60Sribosomal subunit biogenesis; localizes to bothnucleolus and cytoplasm 0.000530.02536 S000005867RPA43YOR340CverifiedRNA polymerase I subunit A43 0.000530.02536&radic S000000781POL5YEL055CverifiedProtein with sequence similarity to the human MybBP1A and weaksequence similar to B-type DNA polymerases, notrequired for chromosomal DNA replication;required for the synthesis of rRNA 0.000530.02536 S000004262YCS4YLR272CverifiedNon-SMC subunit of the condensin complex(Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required forestablishment and maintenance of chromosomecondensation, chromosome segregation, chromatinbinding of condensin and silencing at themating type locus 0.000520.02525&radic&radic S000003427SKI6YGR195Wverified3'-to-5' phosphorolytic exoribonuclease that is a subunit ofthe exosome; required for 3' processing of the5.8S rRNA; involved in 3' to 5' mRNAdegradation and translation inhibition ofnon-poly(A) mRNAs 0.000520.02512&radic&radic S000004058FYV7YLR068WverifiedProtein of unknown function, required for survival uponexposure to K1 killer toxin; involved inprocessing the 35S rRNA primary transcript togenerate the 20S and 27SA2 pre-rRNA transcripts 0.000520.02512&radic&radic S000005798YTM1YOR272WverifiedConstituent of 66S pre-ribosomal particles, required formaturation of the large ribosomal subunit 0.000520.02512 S000007455NOP10YHR072W-AverifiedConstituent of small nucleolar ribonucleoprotein particlescontaining H/ACA-type snoRNAs, which arerequired for pseudouridylation and processingof pre-18S rRNA 0.000520.02512 S000001052RPL27AYHR010WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl27Bp and has similarity to ratL27 ribosomal protein 0.000520.02512&radic S000000100UTP20YBL004WverifiedComponent of the small-subunit (SSU) processome, which isinvolved in the biogenesis of the 18S rRNA 0.000520.02512 S000005076KRE33YNL132WverifiedEssential protein of unknown function; heterozygous mutantshows haploinsufficiency in K1 killer toxinresistance 0.000510.0246 S000001353YIL091CUncharacterizedProtein required for cell viability 0.00050.02406 S000007223LUG1YCR087C-AuncharacterizedPutative protein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to thenucleolus; YCR087C-A is not an essential gene 0.00050.02406 S000003612NET1YJL076WverifiedCore subunit of the RENT complex, which is a complex involvedin nucleolar silencing and telophase exit;stimulates transcription by RNA polymerase Iand regulates nucleolar structure 0.00050.02406 S000001108SSF1YHR066WverifiedConstituent of 66S pre-ribosomal particles, required forribosomal large subunit maturation;functionally redundant with Ssf2p; member ofthe Brix family 0.00050.02406&radic S000003824RPA12YJR063WverifiedRNA polymerase I subunit A12.2; contains two zinc bindingdomains, and the N terminal domain isresponsible for anchoring to the RNA pol Icomplex 0.000510.02406 S000002857UTP6YDR449CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.00050.02406 S000005321DBP6YNR038WverifiedEssential protein involved in ribosome biogenesis; putativeATP-dependent RNA helicase of the DEAD-boxprotein family 0.00050.02406 S000006347RRP15YPR143WverifiedNucleolar protein, constituent of pre-60S ribosomal particles;required for processing of the 27S pre-rRNA atthe A2 site to yield 5.8S and 25S rRNA 0.00050.02406&radic S000004041FCF2YLR051CverifiedEssential nucleolar protein involved in the early steps of 35SrRNA processing; interacts with Faf1p; memberof a transcriptionally co-regulated set ofgenes called the RRB regulon 0.000510.02406 S000004558UTP14YML093WverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.000490.02252 S000003322UTP22YGR090WuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.00050.02252 S000003726RPS22AYJL190CverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps22Bp and has similarity to E.coli S8 and rat S15a ribosomal proteins 0.000490.02252&radic S000004539FPR3YML074CverifiedNucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506binding protein; phosphorylated by caseinkinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) anddephosphorylated by Ptp1p 0.00050.02252 S000000808NUG1YER006WverifiedGTPase that associates with nuclear 60S pre-ribosomes, requiredfor export of 60S ribosomal subunits from thenucleus 0.00050.02252&radic S000005964NOP4YPL043WverifiedNucleolar protein, essential for processing and maturation of27S pre-rRNA and large ribosomal subunitbiogenesis; constituent of 66S pre-ribosomalparticles; contains four RNA recognition motifs(RRMs) 0.00050.02252&radic S000001131GAR1YHR089CverifiedProtein component of the H/ACA snoRNP pseudouridylase complex,involved in the modification and cleavage ofthe 18S pre-rRNA 0.00050.02252 S000000124YBL028CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis 0.000490.02252 S000006220TIF6YPR016CverifiedConstituent of 66S pre-ribosomal particles, has similarity tohuman translation initiation factor 6 (eIF6);may be involved in the biogenesis and orstability of 60S ribosomal subunits 0.000490.02252 S000004507RRN11YML043CverifiedProtein required for rDNA transcription by RNA polymerase I,component of the core factor (CF) of rDNAtranscription factor, which also contains Rrn6pand Rrn7p 0.000490.02236 S000004738RRB1YMR131CverifiedEssential nuclear protein involved in early steps of ribosomebiogenesis; physically interacts with theribosomal protein Rpl3p 0.000490.02211 S000000451ENP1YBR247CverifiedProtein associated with U3 and U14 snoRNAs, required forpre-rRNA processing and 40S ribosomal subunitsynthesis; localized in the nucleus andconcentrated in the nucleolus 0.000480.02184&radic&radic S000001608RRN3YKL125WverifiedProtein required for transcription of rDNA by RNA polymerase I;transcription factor independent of DNAtemplate; involved in recruitment of RNApolymerase I to rDNA 0.000480.02184 S000003934SOF1YLL011WverifiedEssential subunit of the U3 (box C+D) snRNP complex requiredfor 2' O-methylation of pre-RNA; has similarityto the beta subunit of trimeric G-proteins andthe splicing factor Prp4p 0.000480.02147&radic S000007608YGR271C-AUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus 0.000470.02053 S000002372NOP6YDL213CuncharacterizedProtein with similarity to hydrophilins, which are involved inthe adaptive response to hyperosmoticconditions; computational analysis oflarge-scale protein-protein interaction datasuggests a possible role in rRNA processing 0.000470.02046 S000002269RRP42YDL111CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp4p, Rrp41p,Rrp43p and Dis3p 0.000470.02024 S000001789RPF2YKR081CverifiedEssential protein involved in the processing of pre-rRNA andthe assembly of the 60S ribosomal subunit;interacts with ribosomal protein L11; localizespredominantly to the nucleolus; constituent of66S pre-ribosomal particles 0.000460.01984&radic S000000346MAK5YBR142WverifiedEssential nucleolar protein, putative DEAD-box RNA helicaserequired for maintenance of M1 dsRNA virus;involved in biogenesis of large (60S) ribosomalsubunits 0.000460.01984 S000001924CDC14YFR028CverifiedProtein phosphatase required for mitotic exit; located in thenucleolus until liberated by the FEAR andMitotic Exit Network in anaphase, enabling itto act on key substrates to effect a decreasein CDK/B-cyclin activity and mitotic exit 0.000470.01984 S000000653PWP2YCR057CverifiedConserved 90S pre-ribosomal component essential for properendonucleolytic cleavage of the 35 S rRNAprecursor at A0, A1, and A2 sites; containseight WD-repeats; PWP2 deletion leads todefects in cell cycle and bud morphogenesis 0.000460.01955 S000003483YGR251WUncharacterizedPutative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene 0.000450.01935 S000006126YPL205CDubiousHypothetical protein; deletion of locus affects telomere length 0.000440.01915&radic&radic S000003006OCH1YGL038CverifiedMannosyltransferase of the cis-Golgi apparatus, initiates thepolymannose outer chain elongation of N-linkedoligosaccharides of glycoproteins 0.000450.01915&radic&radic S000005172YNL228WDubiousHypothetical protein 0.000440.01915 S000003705YJL169WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2 0.000440.01915 S000002649BUD26YDR241WdubiousDubious open reading frame, unlikely to encode a protein; notconserved in closely related Saccharomycesspecies; 1% of ORF overlaps the verified geneSNU56; diploid mutant displays a weak buddingpattern phenotype in a systematic assay 0.000440.0189 S000003392YGR160WDubiousHypothetical protein 0.000440.0189&radic&radic S000000563FYV5YCL058CdubiousProtein of unknown function, required for survival uponexposure to K1 killer toxin; involved in ionhomeostasis 0.000440.0189 S000005437BRX1YOL077CverifiedNucleolar protein, constituent of 66S pre-ribosomal particles;depletion leads to defects in rRNA processingand a block in the assembly of large ribosomalsubunits; possesses a sigma(70)-likeRNA-binding motif 0.000440.0189&radic&radic S000000513YCL007CDubiousDubious ORF unlikely to encode a protein; overlaps verified ORF YCL005W-A; mutations in YCL007C were thought to confer sensitivity to calcofluor white, but this phenotype was later shown to be due to the defect in YCL005W-A 0.000440.0189&radic S000001172YHR130CDubiousHypothetical protein 0.000440.0189 S000003186YGL218WDubiousDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance 0.000440.0189 S000000785YEL059WDubiousHypothetical protein 0.000440.0189&radic S000000110RRN6YBL014CverifiedProtein involved in the transcription of 35S rRNA genes by RNApolymerase I; component of the core factor (CF)complex also composed of Rrn11p, Rrn7p andTATA-binding protein 0.000430.01861&radic&radic S000006278TKL1YPR074CverifiedTransketolase, similar to Tkl2p; catalyzes conversion ofxylulose-5-phosphate and ribose-5-phosphate tosedoheptulose-7-phosphate andglyceraldehyde-3-phosphate in the pentosephosphate pathway; needed for synthesis ofaromatic amino acids 0.000430.01861 S000004486RPS17AYML024WverifiedRibosomal protein 51 (rp51) of the small (40s) subunit; nearlyidentical to Rps17Bp and has similarity to ratS17 ribosomal protein 0.000430.01861&radic S000005433THP1YOL072WverifiedNuclear pore-associated protein, forms a complex with Sac3pthat is involved in transcription and in mRNAexport from the nucleus; contains a PAM domainimplicated in protein-protein binding 0.000420.01796&radic S000000398SOY1YBR194WuncharacterizedProtein proposed to be associated with the nuclear pore complex 0.000420.01796&radic S000000804NOP16YER002WverifiedConstituent of 66S pre-ribosomal particles, involved in 60Sribosomal subunit biogenesis 0.000420.01796&radic&radic S000004924GAS1YMR307WverifiedBeta-1.3-glucanosyltransferase, required for cell wallassembly; localizes to the cell surface via aglycosylphosphatidylinositol (GPI) anchor 0.000420.01796&radic&radic S000003350RPS23AYGR118WverifiedRibosomal protein 28 (rp28) of the small (40S) ribosomalsubunit, required for translational accuracy;nearly identical to Rps23Bp and similar to E.coli S12 and rat S23 ribosomal proteins;deletion of both RPS23A and RPS23B is lethal 0.000420.01789 S000001489RPL14AYKL006WverifiedN-terminally acetylated protein component of the large (60S)ribosomal subunit, nearly identical to Rpl14Bpand has similarity to rat L14 ribosomalprotein; rpl14a csh5 double null mutantexhibits synthetic slow growth 0.000410.01754 S000005441IRA2YOL081WverifiedGTPase-activating protein that negatively regulates RAS byconverting it from the GTP- to the GDP-boundinactive form, required for reducing cAMPlevels under nutrient limiting conditions, hassimilarity to Ira1p and human neurofibromin 0.000410.01722&radic S000000780RPL12AYEL054CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl12Bp; rpl12a rpl12b doublemutant exhibits slow growth and slowtranslation; has similarity to E. coli L11 andrat L12 ribosomal proteins 0.00040.01709&radic S000003484GCN5YGR252WverifiedHistone acetyltransferase, acetylates N-terminal lysines onhistones H2B and H3; catalytic subunit of theADA and SAGA histone acetyltransferasecomplexes; founding member of the Gcn5p-relatedN-acetyltransferase superfamily 0.00040.01671 S000005351YNR068CUncharacterizedHypothetical protein 0.00040.01671 S000002566SAC3YDR159WverifiedNuclear pore-associated protein, forms a complex with Thp1pthat is involved in transcription and in mRNAexport from the nucleus 0.00040.01671&radic&radic S000003420BUB1YGR188CverifiedProtein kinase that forms a complex with Mad1p and Bub3p thatis crucial in the checkpoint mechanism requiredto prevent cell cycle progression into anaphasein the presence of spindle damage, associateswith centromere DNA via Skp1p 0.00040.01671 S000000521DCC1YCL016CverifiedSubunit of a complex with Ctf8p and Ctf18p that shares somecomponents with Replication Factor C, requiredfor sister chromatid cohesion and telomerelength maintenance 0.00040.01671&radic S000004439VMA6YLR447CverifiedSubunit D of the five-subunit V0 integral membrane domain ofvacuolar H+-ATPase (V-ATPase), an electrogenicproton pump found in the endomembrane system;stabilizes VO subunits; required for V1 domainassembly on the vacuolar membrane 0.00040.01671 S000004230VPS34YLR240WverifiedPhosphatidylinositol 3-kinase responsible for the synthesis ofphosphatidylinositol 3-phosphate; formsmembrane-associated signal transduction complexwith Vps15p to regulate protein sorting;activated by the GTP-bound form of Gpa1p 0.00040.01671&radic&radic S000005293CSE2YNR010WverifiedComponent of the Med9/10 module, which is a subcomplex withinthe RNA polymerase II Mediator complex;required for regulation of RNA polymerase IIactivity 0.00040.01667 S000001102VMA22YHR060WverifiedIntegral membrane protein that is required for vacuolarH+-ATPase (V-ATPase) function, although not anactual component of the V-ATPase complex;functions in the assembly of the V-ATPase;localized to the yeast endoplasmic reticulum(ER) 0.00040.01667&radic&radic S000003676RPB4YJL140WverifiedRNA polymerase II subunit B32; forms two subunit dissociablecomplex with Rpb7p; dispensable under someenvironmental conditions; involved in export ofmRNA to cytoplasm under stress conditions;involved in telomere maintenance 0.00040.01667 S000000393RPS9BYBR189WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps9Ap and has similarity to E.coli S4 and rat S9 ribosomal proteins 0.00040.01652 S000001626LTV1YKL143WverifiedComponent of the GSE complex, which is required for propersorting of amino acid permease Gap1p; requiredfor ribosomal small subunit export fromnucleus; required for growth at low temperature 0.00040.01652 S000006363KRE6YPR159WverifiedProtein required for beta-1,6 glucan biosynthesis; putativebeta-glucan synthase; appears functionallyredundant with Skn1p 0.000390.01592&radic S000002351ARF1YDL192WverifiedADP-ribosylation factor, GTPase of the Ras superfamily involvedin regulation of coated formation vesicles inintracellular trafficking within the Golgi;functionally interchangeable with Arf2p 0.000390.01592&radic&radic S000002424KCS1YDR017CverifiedInositol hexaphosphate kinase, phosphorylates inositolhexakisphosphate (InsP6) to diphosphoinositolpolyphosphates, required for proper vacuolemorphology and involved in salt stressresponse, contains two leucine heptad repeats 0.00040.01592 S000004017AAT2YLR027CverifiedCytosolic aspartate aminotransferase, involved in nitrogenmetabolism; localizes to peroxisomes inoleate-grown cells 0.000390.01537&radic S000000733YEL007WUncharacterizedPutative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) 0.000390.01537&radic S000001237MDM31YHR194WverifiedMitochondrial inner membrane protein with similarity to Mdm32p,required for normal mitochondrial morphologyand inheritance; interacts genetically withMMM1, MDM10, MDM12, and MDM34 0.000380.01452 S000006335NAT3YPR131CverifiedCatalytic subunit of the NatB N-terminal acetyltransferase,which catalyzes acetylation of theamino-terminal methionine residues of allproteins beginning with Met-Asp or Met-Glu andof some proteins beginning with Met-Asn orMet-Met 0.000380.01452 S000000285SPT7YBR081CverifiedSubunit of the SAGA transcriptional regulatory complex,involved in proper assembly of the complex;also present as a C-terminally truncated formin the SLIK/SALSA transcriptional regulatorycomplex 0.000380.01452 S000003215RAI1YGL246CverifiedNuclear protein that binds to and stabilizes theexoribonuclease Rat1p, required for pre-rRNAprocessing 0.000380.01452&radic S000005666SFL1YOR140WverifiedTranscription repressor involved in regulation offlocculation-related genes, inhibitstranscription by recruiting general corepressorCyc8p-Tup1p to different promoters; negativelyregulated by cAMP-dependent protein kinase Asubunit Tpk2p 0.000380.01452&radic&radic S000002672AKR1YDR264CverifiedPalmitoyl transferase involved in protein palmitoylation; actsas a negative regulator of pheromone responsepathway; required for endocytosis of pheromonereceptors; involved in cell shape control;contains ankyrin repeats 0.000380.01452 S000000175NUP170YBL079WverifiedAbundant subunit of the nuclear pore complex (NPC), requiredfor proper localization of specificnucleoporins within the NPC, involved innuclear envelope permeability and in chromosomesegregation, has similarity to Nup157p 0.000380.01452 S000005561SHE4YOR035CverifiedProtein containing a UCS (UNC-45/CRO1/SHE4) domain, binds tomyosin motor domains to regulate myosinfunction; involved in endocytosis, polarizationof the actin cytoskeleton, and asymmetric mRNAlocalization 0.000380.01452&radic S000004254RPS28BYLR264WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps28Ap and has similarity to ratS28 ribosomal protein 0.000380.01452 S000003174CHC1YGL206CverifiedClathrin heavy chain, subunit of the major coat proteininvolved in intracellular protein transport andendocytosis; two heavy chains form the clathrintriskelion structural component; the lightchain (CLC1) is thought to regulate function 0.000380.01452 S000006046KAP120YPL125WverifiedKaryopherin with a role in the assembly or export of 60Sribosomal subunits 0.000380.01452&radic&radic S000006114RSA1YPL193WverifiedProtein involved in the assembly of 60S ribosomal subunits;functionally interacts with Dbp6p; functions ina late nucleoplasmic step of the assembly 0.000380.01452&radic S000000024DRS2YAL026CverifiedAminophospholipid translocase (flippase) that maintainsmembrane lipid asymmetry in post-Golgisecretory vessicles; localizes to thetrans-Golgi network; contributes toclathrin-coated vesicle formation andendocytosis; type 4 P-type ATPase 0.000380.01408&radic S000003529QCR10YHR001W-AverifiedSubunit of the ubiqunol-cytochrome c oxidoreductase complex,involved in aerobic respiration 0.000380.01408 S000001071YHI9YHR029CverifiedProtein of unknown function that is a member of the PhzFsuperfamily, although unlike its bacterialhomolog, is most likely not involved inphenazine production; possibly involved in amembrane regulation metabolic pathway 0.000370.01408&radic S000002790RPP2BYDR382WverifiedRibosomal protein P2 beta, a component of the ribosomal stalk,which is involved in the interaction betweentranslational elongation factors and theribosome; regulates the accumulation of P1(Rpp1Ap and Rpp1Bp) in the cytoplasm 0.000380.01408 S000005196MRPL17YNL252CverifiedMitochondrial ribosomal protein of the large subunit 0.000380.01408 S000006000RPL21BYPL079WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl21Ap and has similarity to ratL21 ribosomal protein 0.000380.01408 S000005952PHO85YPL031CverifiedCyclin-dependent kinase, with ten cyclin partners; involved inenvironmental stress response; inphosphate-rich conditions, Pho85p-Pho80pcomplex phosphorylates Pho4p which in turnrepresses PHO5 0.000370.01408&radic S000006175HFI1YPL254WverifiedAdaptor protein required for structural integrity of the SAGAcomplex, a histoneacetyltransferase-coactivator complex that isinvolved in global regulation of geneexpression through acetylation andtranscription functions 0.000380.01408&radic S000002391OST4YDL232WverifiedSubunit of the oligosaccharyltransferase complex of the ERlumen, which catalyzes proteinasparagine-linked glycosylation; type Imembrane protein required for incorporation ofOst3p or Ost6p into the OST complex 0.000380.01408 S000005735NPT1YOR209CverifiedNicotinate phosphoribosyltransferase, acts in the salvagepathway of NAD+ biosynthesis; required forsilencing at rDNA and telomeres and has a rolein silencing at mating-type loci; localized tothe nucleus 0.000370.0138&radic S000005246RPS19BYNL302CverifiedProtein component of the small (40S) ribosomal subunit,required for assembly and maturation of pre-40S particles; mutations in human RPS19 areassociated with Diamond Blackfan anemia; nearlyidentical to Rps19Ap 0.000370.0135&radic S000001068PPA1YHR026WverifiedSubunit c'' of the vacuolar ATPase, which functions inacidification of the vacuole; one of threeproteolipid subunits of the V0 domain 0.000370.0135 S000001025RPL8AYHL033CverifiedRibosomal protein L4 of the large (60S) ribosomal subunit,nearly identical to Rpl8Bp and has similarityto rat L7a ribosomal protein; mutation resultsin decreased amounts of free 60S subunits 0.000370.0135&radic S000005173URE2YNL229CverifiedNitrogen catabolite repression regulator that acts byinhibition of GLN3 transcription in goodnitrogen source; altered form of Ure2p creates[URE3] prion 0.000370.01337&radic S000000885GET2YER083CverifiedSubunit of the GET complex; required for meiotic nucleardivision and for the retrieval of HDEL proteinsfrom the Golgi to the ER in an ERD2 dependentfashion; may be involved in cell wall function 0.000370.01337 S000006155TFP3YPL234CverifiedVacuolar ATPase V0 domain subunit c', involved in protontransport activity; hydrophobic integralmembrane protein (proteolipid) containing fourtransmembrane segments; N and C termini are inthe vacuolar lumen 0.000370.01337 S000002940YDR532CUncharacterizedProtein of unknown function that localizes to the nuclear side of the spindle pole body and along short spindles; deletion mutants have short telomeres; forms a complex with Spc105p 0.000370.01337 S000005224ERG24YNL280CverifiedC-14 sterol reductase, acts in ergosterol biosynthesis; mutantsaccumulate the abnormal sterol ignosterol(ergosta-8,14 dienol), and are viable underanaerobic growth conditions but inviable onrich medium under aerobic conditions 0.000370.01337&radic S000001659LST4YKL176CverifiedProtein possibly involved in a post-Golgi secretory pathway;required for the transport ofnitrogen-regulated amino acid permease Gap1pfrom the Golgi to the cell surface 0.000360.01334&radic S000005632VAM3YOR106WverifiedSyntaxin-related protein required for vacuolar assembly;functions with Vam7p in vacuolar proteintrafficking; member of the syntaxin family ofproteins 0.000360.01332&radic&radic S000003720GON7YJL184WverifiedProtein proposed to be involved in the modification of N-linkedoligosaccharides, osmotic stress response,telomere uncapping and elongation,transcription; component of the EKC/KEOPSprotein complex with Kae1p, Cgi121p, Pcc1p, andBud32p 0.000360.01332 S000000142PSY4YBL046WverifiedPutative regulatory subunit of an evolutionarily conservedprotein phosphatase complex containing thecatalytic subunit Pph3p and a third subunitPsy2p; required for cisplatin resistance;GFP-fusion protein localizes to the nucleus 0.000360.01332 S000004641CCS1YMR038CverifiedCopper chaperone for superoxide dismutase Sod1p, involved inoxidative stress protection; Met-X-Cys-X2-Cysmotif within the N-terminal portion is involvedin insertion of copper into Sod1p underconditions of copper deprivation 0.000360.01319 S000005970DIG1YPL049CverifiedRegulatory protein of unknown function,constitutively-expressed, involved in theregulation of mating-specific genes and theinvasive growth pathway, required forMAP-kinase imposed repression, inhibitspheromone-responsive transcription 0.000360.01319 S000002481TPS2YDR074WverifiedPhosphatase subunit of the trehalose-6-phosphatesynthase/phosphatase complex, which synthesizesthe storage carbohydrate trehalose; expressionis induced by stress conditions and repressedby the Ras-cAMP pathway 0.000360.01319 S000005077FYV6YNL133CverifiedProtein of unknown function, required for survival uponexposure to K1 killer toxin; proposed toregulate double-strand break repair vianon-homologous end-joining 0.000360.01317 S000005306SNF12YNR023Wverified73 kDa subunit of the SWI/SNF chromatin remodeling complexinvolved in transcriptional regulation; homologof Rsc6p subunit of the RSC chromatinremodeling complex; deletion mutants aretemperature-sensitive 0.000360.01317 S000006022ELP4YPL101WverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;required for Elongator structural integrity 0.000360.01291 S000005436MDM20YOL076WverifiedNon-catalytic subunit of the NatB N-terminal acetyltransferase,which catalyzes acetylation of theamino-terminal methionine residues of allproteins beginning with Met-Asp or Met-Glu andof some proteins beginning with Met-Asn orMet-Met; involved in mitochondrial inheritanceand actin assembly 0.000360.01291&radic&radic S000001609YPK1YKL126WverifiedSerine/threonine protein kinase required for receptor-mediatedendocytosis; involved in sphingolipid-mediatedand cell integrity signaling pathways;localized to the bud neck, cytosol and plasmamembrane; homolog of mammalian kinase SGK 0.000360.01289&radic&radic S000001602VPH2YKL119CverifiedIntegral membrane protein required for vacuolar H+-ATPase(V-ATPase) function, although not an actualcomponent of the V-ATPase complex; functions inthe assembly of the V-ATPase; localized to theendoplasmic reticulum (ER) 0.000350.01279&radic S000006109POS5YPL188WverifiedMitochondrial NADH kinase, phosphorylates NADH; alsophosphorylates NAD(+) with lower specificity;required for the response to oxidative stress 0.000360.01279&radic S000002490RRP8YDR083WverifiedNucleolar protein involved in rRNA processing, pre-rRNAcleavage at site A2; also involved in telomeremaintenance; mutation is synthetically lethalwith a gar1 mutation 0.000350.01278&radic S000000842GLN3YER040WverifiedTranscriptional activator of genes regulated by nitrogencatabolite repression (NCR), localization andactivity regulated by quality of nitrogensource 0.000350.01278&radic&radic S000000872RNR1YER070WverifiedRibonucleotide-diphosphate reductase (RNR), large subunit; theRNR complex catalyzes the rate-limiting step indNTP synthesis and is regulated by DNAreplication and DNA damage checkpoint pathwaysvia localization of the small subunits 0.000350.01275&radic S000004818PFK2YMR205CverifiedBeta subunit of heterooctameric phosphofructokinase involved inglycolysis, indispensable for anaerobic growth,activated by fructose-2,6-bisphosphate and AMP,mutation inhibits glucose induction of cellcycle-related genes 0.000350.01243&radic S000001878MDJ1YFL016CverifiedProtein involved in folding of mitochondrially synthesizedproteins in the mitochondrial matrix; localizesto the mitochondrial inner membrane; member ofthe DnaJ family of molecular chaperones 0.000350.01243 S000004970SSN8YNL025CverifiedCyclin-like component of the RNA polymerase II holoenzyme,involved in phosphorylation of the RNApolymerase II C-terminal domain; involved inglucose repression and telomere maintenance 0.000350.01243 S000005008YDJ1YNL064CverifiedProtein chaperone involved in regulation of the HSP90 and HSP70functions; involved in protein translocationacross membranes; member of the DnaJ family 0.000350.01243 S000005121MRPL22YNL177CverifiedMitochondrial ribosomal protein of the large subunit 0.000350.01243&radic S000006367TIF3YPR163CverifiedTranslation initiation factor eIF-4B, has RNA annealingactivity; contains an RNA recognition motif andbinds to single-stranded RNA 0.000350.01243&radic&radic S000003044RPL7AYGL076CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl7Bp and has similarity to E.coli L30 and rat L7 ribosomal proteins;contains a conserved C-terminal Nucleic acidBinding Domain (NDB2) 0.000350.01243&radic S000004466YAP1YML007WverifiedBasic leucine zipper (bZIP) transcription factor required foroxidative stress tolerance; mediatespleiotropic drug and metal resistance;localized to the nucleus in response to thepresence of oxidants 0.000350.01243&radic S000001876LPD1YFL018CverifiedDihydrolipoamide dehydrogenase, the lipoamide dehydrogenasecomponent (E3) of the pyruvate dehydrogenaseand 2-oxoglutarate dehydrogenase multi-enzymecomplexes 0.000350.01243 S000001563VMA5YKL080WverifiedSubunit C of the eight-subunit V1 peripheral membrane domain ofvacuolar H+-ATPase (V-ATPase), an electrogenicproton pump found throughout the endomembranesystem; required for the V1 domain to assembleonto the vacuolar membrane 0.000350.01243 S000007224YPL183W-AUncharacterizedHomolog of the prokaryotic ribosomal protein L36, likely to be a mitochondrial ribosomal protein coded in the nuclear genome 0.000350.01235 S000003034SGF73YGL066Wverified73 kDa subunit of SAGA histone acetyltransferase complex;involved in formation of the preinitiationcomplex assembly at promoters 0.000350.01235&radic S000003336SRB5YGR104CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation; involved intelomere maintenance 0.000340.01229&radic S000004815ERG2YMR202WverifiedC-8 sterol isomerase, catalyzes the isomerization of thedelta-8 double bond to the delta-7 position atan intermediate step in ergosterol biosynthesis 0.000340.0122&radic&radic S000001063RPS27BYHR021CverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps27Ap and has similarity to ratS27 ribosomal protein 0.000340.0122 S000000821ISC1YER019WverifiedInositol phosphosphingolipid phospholipase C, hydrolyzesinositolphosphosphingolipids, activated byphosphatidylserine, cardiolipin, andphosphatidylglycerol, mediates Na+ and Li+halotolerance, contains a P loop-like domain 0.000340.0122 S000001083SRB2YHR041CverifiedGeneral transcription factor, subunit of the RNA polymerase IImediator complex; associates with corepolymerase subunits to form the RNA polymeraseII holoenzyme; involved in telomere maintenance 0.000340.012 S000002610RAV2YDR202CverifiedSubunit of RAVE (Rav1p, Rav2p, Skp1p), a complex thatassociates with the V1 domain of the vacuolarmembrane (H+)-ATPase (V-ATPase) and promotesassembly and reassembly of the holoenzyme 0.000340.012 S000005565CKB2YOR039WverifiedBeta' regulatory subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKA2 and CKB1, the many substratesinclude transcription factors and all RNApolymerases 0.000340.012&radic&radic S000002363RTN2YDL204WverifiedProtein of unknown function; has similarity to mammalianreticulon proteins; member of the RTNLA(reticulon-like A) subfamily 0.000340.012 S000001687EAP1YKL204WverifiedeIF4E-associated protein, binds eIF4E and inhibitscap-dependent translation, also functionsindependently of eIF4E to maintain geneticstability; plays a role in cell growth,implicated in the TOR signaling cascade 0.000340.012 S000005164ADE12YNL220WverifiedAdenylosuccinate synthase, catalyzes the first committed stepin the 'de novo' biosynthesis of adenosine 0.000340.012 S000003472PFK1YGR240CverifiedAlpha subunit of heterooctameric phosphofructokinase involvedin glycolysis, indispensable for anaerobicgrowth, activated by fructose-2,6-bisphosphateand AMP, mutation inhibits glucose induction ofcell cycle-related genes 0.000340.012&radic S000006011RPS6AYPL090CverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps6Bp and has similarity to ratS6 ribosomal protein 0.000340.01191 S000001728VPS51YKR020WverifiedComponent of the GARP (Golgi-associated retrograde protein)complex, Vps51p-Vps52p-Vps53p-Vps54p, which isrequired for the recycling of proteins fromendosomes to the late Golgi; links the(VFT/GARP) complex to the SNARE Tlg1p 0.000340.01186&radic S000002580ARG82YDR173CverifiedInositol polyphosphate multikinase (IPMK), sequentiallyphosphorylates Ins(1,4,5)P3 to formIns(1,3,4,5,6)P5; putative nuclear lipidinositol PI3-kinase; regulates arginine-,phosphate-, and nitrogen-responsive genes 0.000330.01172&radic S000001226GND1YHR183Wverified6-phosphogluconate dehydrogenase (decarboxylating), catalyzesan NADPH regenerating reaction in the pentosephosphate pathway; required for growth onD-glucono-delta-lactone and adaptation tooxidative stress 0.000330.01172&radic&radic S000004851DFG5YMR238WverifiedPutative mannosidase, essential glycosylphosphatidylinositol(GPI)-anchored membrane protein required forcell wall biogenesis in bud formation, involvedin filamentous growth, homologous to Dcw1p 0.000330.01155&radic S000004500CGI121YML036WverifiedProtein involved in telomere uncapping and elongation ascomponent of the KEOPS protein complex withBud32p, Kae1p, Pcc1p, and Gon7p; also shown tobe a component of the EKC protein complex;homolog of human CGI-121 0.000330.01143 S000004334FKS1YLR342WverifiedCatalytic subunit of 1,3-beta-D-glucan synthase, functionallyredundant with alternate catalytic subunitGsc2p; binds to regulatory subunit Rho1p;involved in cell wall synthesis andmaintenance; localizes to sites of cell wallremodeling 0.000330.01143&radic S000004051RPL22AYLR061WverifiedProtein component of the large (60S) ribosomal subunit, hassimilarity to Rpl22Bp and to rat L22 ribosomalprotein 0.000330.01143 S000004046ERG3YLR056WverifiedC-5 sterol desaturase, catalyzes the introduction of a C-5(6)double bond into episterol, a precursor inergosterol biosynthesis; mutants are viable,but cannot grow on non-fermentable carbonsources 0.000330.01143&radic S000006432EST3YIL009C-AverifiedComponent of the telomerase holoenzyme, involved in telomerereplication 0.000330.01137 S000002603REF2YDR195WverifiedRNA-binding protein involved in the cleavage step of mRNA3'-end formation prior to polyadenylation, andin snoRNA maturation; part of holo-CPFsubcomplex APT, which associates with 3'-endsof snoRNA- and mRNA-encoding genes 0.000330.01137&radic S000000273TAT1YBR069CverifiedAmino acid transport protein for valine, leucine, isoleucine,and tyrosine, low-affinity tryptophan andhistidine transporter; overexpression confersFK506 resistance 0.000330.01128 S000000677SRB8YCR081WverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation; involved in glucoserepression 0.000330.01128 S000004635HOF1YMR032WverifiedBud neck-localized, SH3 domain-containing protein required forcytokinesis; regulates actomyosin ring dynamicsand septin localization; interacts with theformins, Bni1p and Bnr1p, and with Cyk3p,Vrp1p, and Bni5p 0.000330.01084&radic S000001715MEH1YKR007WverifiedComponent of the EGO complex, which is involved in theregulation of microautophagy, and of the GSEcomplex, which is required for proper sortingof amino acid permease Gap1p; loss results in adefect in vacuolar acidification 0.000330.01084&radic S000002178RPN4YDL020CverifiedTranscription factor that stimulates expression of proteasomegenes; Rpn4p levels are in turn regulated bythe 26S proteasome in a negative feedbackcontrol mechanism; RPN4 is transcriptionallyregulated by various stress responses 0.000320.01084 S000002344TFP1YDL185WverifiedVacuolar ATPase V1 domain subunit A containing the catalyticnucleotide binding sites; protein precursorundergoes self-catalyzed splicing to yield theextein Tfp1p and the intein Vde (PI-SceI),which is a site-specific endonuclease 0.000320.01084 S000000755BUD16YEL029CverifiedProtein involved in bud-site selection and telomeremaintenance; diploid mutants display a randombudding pattern instead of the wild-typebipolar pattern; has similarity to pyridoxalkinases 0.000330.01084&radic S000005274RPD3YNL330CverifiedHistone deacetylase; regulates transcription and silencing 0.000320.01076&radic S000002583NGG1YDR176WverifiedTranscriptional regulator involved in glucose repression ofGal4p-regulated genes; component oftranscriptional adaptor and histoneacetyltransferase complexes, the ADA complex,the SAGA complex, and the SLIK complex 0.000320.01076&radic&radic S000003317RPL11BYGR085CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl11Ap; involved in ribosomalassembly; depletion causes degradation ofproteins and RNA of the 60S subunit; hassimilarity to E. coli L5 and rat L11 0.000320.01046 S000000870MOT2YER068WverifiedComponent of the CCR4-NOT complex, which has multiple roles intranscription regulation, mRNA degradation, andpost-transcriptional modifications; with Ubc4p,ubiquitylates subunits of the nascentpolypeptide-associated complex (NAC) 0.000320.01046&radic S000004751RPS16AYMR143WverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps16Bp and has similarity to E.coli S9 and rat S16 ribosomal proteins 0.000320.01046 S000005364SIN3YOL004WverifiedComponent of the Sin3p-Rpd3p histone deacetylase complex,involved in transcriptional repression andactivation of diverse processes, includingmating-type switching and meiosis; involved inthe maintenance of chromosomal integrity 0.000320.01046&radic S000000395RPL21AYBR191WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl21Bp and has similarity to ratL21 ribosomal protein 0.000320.01046 S000002708PRO1YDR300CverifiedGamma-glutamyl kinase, catalyzes the first step in prolinebiosynthesis 0.000320.01046&radic&radic S000002534ARO1YDR127WverifiedPentafunctional arom protein, catalyzes steps 2 through 6 inthe biosynthesis of chorismate, which is aprecursor to aromatic amino acids 0.000320.01041&radic S000002800SPT3YDR392WverifiedSubunit of the SAGA and SAGA-like transcriptional regulatorycomplexes, interacts with Spt15p to activatetranscription of some RNA polymeraseII-dependent genes, also functions to inhibittranscription at some promoters 0.000320.01013&radic&radic S000005251MCK1YNL307CverifiedProtein serine/threonine/tyrosine (dual-specificity) kinaseinvolved in control of chromosome segregationand in regulating entry into meiosis; relatedto mammalian glycogen synthase kinases of theGSK-3 family 0.000310.01013&radic&radic S000003599MRPL8YJL063CverifiedMitochondrial ribosomal protein of the large subunit 0.000320.01013 S000004730PKR1YMR123WverifiedV-ATPase assembly factor, functions with other V-ATPaseassembly factors in the ER to efficientlyassemble the V-ATPase membrane sector(V0); overproduction confersresistance to Pichia farinosa killer toxin 0.000310.01013 S000003866ADO1YJR105WverifiedAdenosine kinase, required for the utilization ofS-adenosylmethionine (AdoMet); may be involvedin recycling adenosine produced through themethyl cycle 0.000310.00983 S000002508ARX1YDR101CverifiedShuttling pre-60S factor; involved in the biogenesis ofribosomal large subunit biogenesis; interactsdirectly with Alb1; responsible for Tif6recycling defects in absence of Rei1;associated with the ribosomal export complex 0.000310.00983 S000001540NUP120YKL057CverifiedSubunit of the Nup84p subcomplex of the nuclear pore complex(NPC), required for even distribution of NPCsaround the nuclear envelope, involved inestablishment of a normal nucleocytoplasmicconcentration gradient of the GTPase Gsp1p 0.000310.00983&radic S000002615UME6YDR207CverifiedKey transcriptional regulator of early meiotic genes, bindsURS1 upstream regulatory sequence, couplesmetabolic responses to nutritional cues withinitiation and progression of meiosis, formscomplex with Ime1p, and also with Sin3p-Rpd3p 0.000310.00936 S000002608VPS64YDR200CverifiedCytoplasmic protein required for cytoplasm to vacuole targetingof proteins; forms a complex with Far3p, Far7p,Far10p, and Far11p that is involved inpheromone-induced cell cycle arrest; alsolocalized to the endoplasmic reticulum membrane 0.000310.00936&radic S000000623FEN2YCR028CverifiedPlasma membrane H+-pantothenate symporter; confers sensitivityto the antifungal agent fenpropimorph 0.00030.00916 S000003222HXK2YGL253WverifiedHexokinase isoenzyme 2 that catalyzes phosphorylation ofglucose in the cytosol; predominant hexokinaseduring growth on glucose; functions in thenucleus to repress expression of HXK1 and GLK1and to induce expression of its own gene 0.00030.00916&radic&radic S000000680TUP1YCR084CverifiedGeneral repressor of transcription, forms complex with Cyc8p,involved in the establishment of repressivechromatin structure through interactions withhistones H3 and H4, appears to enhanceexpression of some genes 0.00030.00905 S000000331VMA2YBR127CverifiedSubunit B of the eight-subunit V1 peripheral membrane domain ofthe vacuolar H+-ATPase (V-ATPase), anelectrogenic proton pump found throughout theendomembrane system; contains nucleotidebinding sites; also detected in the cytoplasm 0.00030.00905 S000004750RPL13BYMR142CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl13Ap; not essential forviability; has similarity to rat L13 ribosomalprotein 0.00030.00886 S000006345KAR3YPR141CverifiedMinus-end-directed microtubule motor that functions in mitosisand meiosis, localizes to the spindle pole bodyand localization is dependent on functionalCik1p, required for nuclear fusion duringmating; potential Cdc28p substrate 0.00030.00886&radic&radic S000001537DEF1YKL054CverifiedRNAPII degradation factor, forms a complex with Rad26p inchromatin, enables ubiquitination andproteolysis of RNAPII present in an elongationcomplex 0.00030.00876 S000000372PEX32YBR168WverifiedPeroxisomal integral membrane protein, involved in negativeregulation of peroxisome size; partiallyfunctionally redundant with Pex31p; geneticinteractions suggest action at a stepdownstream of steps mediated by Pex28p andPex29p 0.00030.00851 S000004361SSQ1YLR369WverifiedMitochondrial hsp70-type molecular chaperone, required forassembly of iron/sulfur clusters into proteinsat a step after cluster synthesis, and formaturation of Yfh1p, which is a homolog ofhuman frataxin implicated in Friedreich'sataxia 0.00030.00851&radic S000001871BUD27YFL023WverifiedProtein involved in bud-site selection, nutrient signaling, andgene expression controlled by the TOR kinase;diploid mutants display a random buddingpattern instead of the wild-type bipolarpattern 0.00030.00851 S000003395GTR2YGR163WverifiedCytoplasmic GTP binding protein that negatively regulatesRan/Tc4 GTPase cycle; subunit of EGO complex,which is involved in microautophagy regulation,and of GSE complex, required for sorting ofGap1p; homolog of human RagC and RagD 0.00030.00851 S000004038RPS0BYLR048WverifiedProtein component of the small (40S) ribosomal subunit, nearlyidentical to Rps0Ap; required for maturation of18S rRNA along with Rps0Ap; deletion of eitherRPS0 gene reduces growth rate, deletion of bothgenes is lethal 0.00030.00843&radic S000006343VPS66YPR139CverifiedCytoplasmic protein of unknown function involved in vacuolarprotein sorting. 0.00030.00843&radic S000000777VMA8YEL051WverifiedSubunit D of the eight-subunit V1 peripheral membrane domain ofthe vacuolar H+-ATPase (V-ATPase), anelectrogenic proton pump found throughout theendomembrane system; plays a role in thecoupling of proton transport and ATP hydrolysis 0.00030.00843&radic S000005622RPS7AYOR096WverifiedProtein component of the small (40S) ribosomal subunit, nearlyidentical to Rps7Bp; interacts with Kti11p;deletion causes hypersensitivity to zymocin;has similarity to rat S7 and Xenopus S8ribosomal proteins 0.000290.00822 S000001472MGA2YIR033WverifiedER membrane protein involved in regulation of OLE1transcription, acts with homolog Spt23p;inactive ER form dimerizes and one subunit isthen activated byubiquitin/proteasome-dependent processingfollowed by nuclear targeting 0.000290.00822&radic S000001221STB5YHR178WverifiedActivator of multidrug resistance genes, forms a heterodimerwith Pdr1p; contains a Zn(II)2Cys6 zinc fingerdomain that interacts with a PDRE (pleotropicdrug resistance element) in vitro; binds Sin3pin a two-hybrid assay 0.000290.00818&radic&radic S000002435REG1YDR028CverifiedRegulatory subunit of type 1 protein phosphatase Glc7p,involved in negative regulation ofglucose-repressible genes 0.000290.00789 S000004354STE11YLR362WverifiedSignal transducing MEK kinase involved in pheromone responseand pseudohyphal/invasive growth pathways whereit phosphorylates Ste7p, and the highosmolarity response pathway, viaphosphorylation of Pbs2p; regulated by Ste20pand Ste50p 0.000290.00789&radic S000002772CDC40YDR364CverifiedPre-mRNA splicing factor, important for catalytic step II ofpre-mRNA splicing and plays a role in cellcycle progression; required for DNA synthesisduring mitosis and meiosis; has WD repeats 0.000290.00789&radic&radic S000000330TPS1YBR126CverifiedSynthase subunit of trehalose-6-phosphate synthase/phosphatasecomplex, which synthesizes the storagecarbohydrate trehalose; also found in amonomeric form; expression is induced by thestress response and repressed by the Ras-cAMPpathway 0.000290.00789 S000002786LSM6YDR378CverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.000290.00789&radic S000000154SHP1YBL058WverifiedUBX (ubiquitin regulatory X) domain-containing protein thatregulates Glc7p phosphatase activity andinteracts with Cdc48p; interacts withubiquitylated proteins in vivo and is requiredfor degradation of a ubiquitylated modelsubstrate 0.000290.00789&radic S000006134LEA1YPL213WverifiedComponent of U2 snRNP; disruption causes reduced U2 snRNPlevels; physically interacts with Msl1p;invovled in telomere maintenance; putativehomolog of human U2A' snRNP protein 0.000280.00762&radic S000005990BTS1YPL069CverifiedGeranylgeranyl diphosphate synthase, increases theintracellular pool of geranylgeranyldiphosphate, suppressor of bet2 mutation thatcauses defective geranylgeranylation of smallGTP-binding proteins that mediate vesiculartraffic 0.000280.00706 S000006274MED1YPR070WverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation 0.000280.00706 S000003925RTT109YLL002WverifiedProtein with a role in regulation of Ty1 transposition 0.000280.00702&radic S000000776RML2YEL050CverifiedMitochondrial ribosomal protein of the large subunit, hassimilarity to E. coli L2 ribosomal protein;fat21 mutant allele causes inability to utilizeoleate and may interfere with activity of theAdr1p transcription factor 0.000280.00681&radic&radic S000003446RPS0AYGR214WverifiedProtein component of the small (40S) ribosomal subunit, nearlyidentical to Rps0Bp; required for maturation of18S rRNA along with Rps0Bp; deletion of eitherRPS0 gene reduces growth rate, deletion of bothgenes is lethal 0.000270.00679 S000001246RPS4BYHR203CverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps4Ap and has similarity to ratS4 ribosomal protein 0.000270.00679 S000001695SAC1YKL212WverifiedLipid phosphoinositide phosphatase of the ER and Golgi,involved in protein trafficking and secretion 0.000270.00669&radic&radic S000004722ASC1YMR116CverifiedWD repeat protein (G-beta like protein) involved in translationregulation; required for repression of Gcn4pactivity in the absence of amino-acidstarvation; core component of the ribosome;ortholog of mammalian RACK1 0.000270.00653 S000005945RMI1YPL024WverifiedInvolved in response to DNA damage; null mutants have increasedrates of recombination and delayed S phase;interacts physically and genetically with Sgs1p(RecQ family member) and Top3p (topoisomeraseIII) 0.000270.00653&radic S000002472YDR065WUncharacterizedProtein of unknown function, required for vacuolar acidification 0.000270.00653&radic&radic S000000471REI1YBR267WverifiedCytoplasmic pre-60S factor; required for the correct recyclingof shuttling factors Alb1, Arx1 and Tif6 at theend of the ribosomal large subunit biogenesis;involved in bud growth in the mitotic signalingnetwork 0.000270.00615&radic S000005934MRPS16YPL013CverifiedMitochondrial ribosomal protein of the small subunit 0.000270.00615 S000000385RPS6BYBR181CverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps6Ap and has similarity to ratS6 ribosomal protein 0.000270.00615 S000002100VMA10YHR039C-AverifiedVacuolar H+ ATPase subunit G of the catalytic (V1) sector,involved in vacuolar acidification 0.000270.00615 S000006050TAF14YPL129WverifiedSubunit (30 kDa) of TFIID, TFIIF, and SWI/SNF complexes,involved in RNA polymerase II transcriptioninitiation and in chromatin modification,contains a YEATS domain 0.000260.00555 S000006328CTR1YPR124WverifiedHigh-affinity copper transporter of the plasma membrane,mediates nearly all copper uptake under lowcopper conditions; transcriptionally induced atlow copper levels and degraded at high copperlevels 0.000260.00555&radic&radic S000005963SSN3YPL042CverifiedCyclin-dependent protein kinase, component of RNA polymerase IIholoenzyme; involved in phosphorylation of theRNA polymerase II C-terminal domain; involvedin glucose repression 0.000260.00555&radic S000004278RPS30AYLR287C-AverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps30Bp and has similarity to ratS30 ribosomal protein 0.000260.00549 S000001106SSZ1YHR064CverifiedHsp70 protein that interacts with Zuo1p (a DnaJ homolog) toform a ribosome-associated complex that bindsthe ribosome via the Zuo1p subunit; alsoinvolved in pleiotropic drug resistance viasequential activation of PDR1 and PDR5; bindsATP 0.000260.00544 S000003657RPE1YJL121CverifiedD-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in thenon-oxidative part of the pentose-phosphatepathway; mutants are sensitive to oxidativestress 0.000250.00521 S000003865SOD1YJR104CverifiedCytosolic superoxide dismutase; some mutations are analogous tothose that cause ALS (amyotrophic lateralsclerosis) in humans 0.000250.00521 S000004258SEC22YLR268WverifiedR-SNARE protein; assembles into SNARE complex with Bet1p, Bos1pand Sed5p; cycles between the ER and Golgicomplex; involved in anterograde and retrogradetransport between the ER and Golgi;synaptobrevin homolog 0.000250.00521&radic S000006240VMA13YPR036WverifiedSubunit H of the eight-subunit V1 peripheral membrane domain ofthe vacuolar H+-ATPase (V-ATPase), anelectrogenic proton pump found throughout theendomembrane system; serves as an activator ora structural stabilizer of the V-ATPase 0.000250.00521 S000006339CTF4YPR135WverifiedChromatin-associated protein, required for sister chromatidcohesion; interacts with DNA polymerase alpha(Pol1p) and may link DNA synthesis to sisterchromatid cohesion 0.000250.00521&radic S000001570CYT2YKL087CverifiedCytochrome c1 heme lyase, involved in maturation of cytochromec1, which is a subunit of the mitochondrialubiquinol-cytochrome-c reductase; links hemecovalently to apocytochrome c1 0.000250.00512 S000005944MET12YPL023CverifiedIsozyme of methylenetetrahydrofolate reductase, catalyzes thereduction of 5,10-methylenetetrahydrofolate to5-methyltetrahydrofolate in the methioninebiosynthesis pathway 0.000250.00512&radic S000001914YFR018CUncharacterizedHypothetical protein 0.000250.00501 S000005335POP2YNR052CverifiedRNase of the DEDD superfamily, subunit of the Ccr4-Not complexthat mediates 3' to 5' mRNA deadenylation 0.000250.00498 S000003191COG1YGL223CverifiedEssential component of the conserved oligomeric Golgi complex(Cog1p through Cog8p), a cytosolic tetheringcomplex that functions in protein traffickingto mediate fusion of transport vesicles toGolgi compartments 0.000250.00498&radic&radic S000000841HVG1YER039CverifiedProtein of unknown function, has homology to Vrg4p 0.000250.00498 S000000702ADH7YCR105WverifiedNADPH-dependent cinnamyl alcohol dehydrogenase family memberwith broad substrate specificity; may beinvolved in fusel alcohol synthesis 0.000250.00489&radic&radic S000003714ATG27YJL178CverifiedType II membrane protein that binds phosphatidylinositol3-phosphate, required for thecytoplasm-to-vacuole targeting (Cvt) pathway 0.000250.00489&radic S000002644FMN1YDR236CverifiedRiboflavin kinase, phosphorylates riboflavin to form riboflavinmonophosphate (FMN), which is a necessarycofactor for many enzymes; localizes tomicrosomes and to the mitochondrial innermembrane 0.000250.00489 S000006313YPR109WUncharacterizedHypothetical protein 0.000250.00489&radic&radic S000002662CHL4YDR254WverifiedOuter kinetochore protein required for chromosome stability,interacts with kinetochore proteins Ctf19p,Ctf3p, and Iml3p; exhibits a two-hybridinteraction with Mif2p; association with CENDNA requires Ctf19p 0.000250.00489&radic S000004610PLB1YMR008CverifiedPhospholipase B (lysophospholipase) involved in lipidmetabolism, required for deacylation ofphosphatidylcholine andphosphatidylethanolamine but notphosphatidylinositol 0.000250.00489&radic S000004006PML1YLR016CverifiedSubunit of the RES complex, which is required for nuclearretention of unspliced pre-mRNAs; acts in thesame pathway as Pml39p and Mlp1p 0.000250.00479&radic S000003252VMA7YGR020CverifiedSubunit F of the eight-subunit V1 peripheral membrane domain ofvacuolar H+-ATPase (V-ATPase), an electrogenicproton pump found throughout the endomembranesystem; required for the V1 domain to assembleonto the vacuolar membrane 0.000250.00479&radic S000004536COG8YML071CverifiedComponent of the conserved oligomeric Golgi complex (Cog1pthrough Cog8p), a cytosolic tethering complexthat functions in protein trafficking tomediate fusion of transport vesicles to Golgicompartments 0.000250.00479 S000006206PDH1YPR002WverifiedMitochondrial protein that participates in respiration, inducedby diauxic shift; homologous to E. coli PrpD,may take part in the conversion of2-methylcitrate to 2-methylisocitrate 0.000250.00473&radic S000002172NOP1YDL014WverifiedNucleolar protein, component of the small subunit processomecomplex, which is required for processing ofpre-18S rRNA; has similarity to mammalianfibrillarin 0.000250.00473 S000028654YHR214C-EUncharacterizedIdentified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 0.000250.00473 S000004202TUB4YLR212CverifiedGamma-tubulin, involved in nucleating microtubules from boththe cytoplasmic and nuclear faces of thespindle pole body 0.000250.00473&radic S000004073EMP70YLR083CverifiedProtein whose 24kDa cleavage product is found inendosome-enriched membrane fractions, predictedto be a transmembrane protein 0.000250.00473&radic S000001667SPE1YKL184WverifiedOrnithine decarboxylase, catalyzes the first step in polyaminebiosynthesis; degraded in aproteasome-dependent manner in the presence ofexcess polyamines 0.000250.00473&radic S000001179ARO9YHR137WverifiedAromatic aminotransferase, catalyzes the first step oftryptophan, phenylalanine, and tyrosinecatabolism 0.000240.00468&radic&radic S000004878YMR265CUncharacterizedHypothetical protein 0.000240.00468 S000006059SPP1YPL138CverifiedSubunit of COMPASS (Set1C), a complex which methylates histoneH3 on lysine 4 and is required in telomerictranscriptional silencing; PHD finger domainprotein similar to human CGBP, an unmethylatedCpG binding protein 0.000240.00468 S000004340DIC1YLR348CverifiedMitochondrial dicarboxylate carrier, integral membrane protein,catalyzes a dicarboxylate-phosphate exchangeacross the inner mitochondrial membrane,transports cytoplasmic dicarboxylates into themitochondrial matrix 0.000240.00468&radic&radic S000004200CLB4YLR210WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the G2/M transition; may beinvolved in DNA replication and spindleassembly; accumulates during S phase and G2,then targeted for ubiquitin-mediateddegradation 0.000240.00468&radic S000004210CCC1YLR220WverifiedPutative vacuolar Fe2+/Mn2+ transporter; suppresses respiratorydeficit of yfh1 mutants, which lack theortholog of mammalian frataxin, by preventingmitochondrial iron accumulation 0.000240.00468&radic S000004173TOS4YLR183CverifiedTranscription factor that binds to a number of promoterregions, particularly promoters of some genesinvolved in pheromone response and cell cycle;potential Cdc28p substrate; expression isinduced in G1 by bound SBF 0.000240.0046&radic S000004027DAN2YLR037CverifiedCell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p,and Tir4p; expressed under anaerobicconditions, completely repressed during aerobicgrowth 0.000240.0046 S000001028MUP3YHL036WverifiedLow affinity methionine permease, similar to Mup1p 0.000240.0046 S000002480SNF11YDR073WverifiedSubunit of the SWI/SNF chromatin remodeling complex involved intranscriptional regulation; interacts with ahighly conserved 40-residue sequence of Snf2p 0.000240.0046&radic&radic S000003712SWI3YJL176CverifiedSubunit of the SWI/SNF chromatin remodeling complex, whichregulates transcription by remodelingchromosomes; required for transcription of manygenes, including ADH1, ADH2, GAL1, HO, INO1 andSUC2 0.000240.0046&radic S000002570CWC15YDR163WverifiedNon-essential protein involved in pre-mRNA splicing, componentof a complex containing Cef1p; has similarityto S. pombe Cwf15p 0.000240.0046&radic S000002597SLY1YDR189WverifiedHydrophilic protein involved in vesicle trafficking between theER and Golgi; SM (Sec1/Munc-18) family proteinthat binds the tSNARE Sed5p and stimulates itsassembly into a trans-SNARE membrane-proteincomplex 0.000240.0046 S000001453YIR014WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene 0.000240.0046 S000003888RSF2YJR127CverifiedZinc-finger protein involved in transcriptional control of bothnuclear and mitochondrial genes, many of whichspecify products required for glycerol-basedgrowth, respiration, and other functions 0.000240.0046 S000004668AEP1YMR064WverifiedProtein required for expression of the mitochondrial OLI1 geneencoding subunit 9 of F1-F0 ATP synthase 0.000240.0046 S000004983GPI15YNL038WverifiedProtein involved in the synthesis of N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI), the firstintermediate in the synthesis ofglycosylphosphatidylinositol (GPI) anchors;homologous to the human PIG-H protein 0.000240.0046 S000006185YPL264CUncharacterizedHypothetical protein 0.000240.0046&radic&radic S000002761TRR1YDR353WverifiedCytoplasmic thioredoxin reductase, key regulatory enzyme thatdetermines the redox state of the thioredoxinsystem, which acts as a disulfide reductasesystem and protects cells against bothoxidative and reductive stress 0.000240.0046&radic S000005702HEM15YOR176WverifiedFerrochelatase, a mitochondrial inner membrane protein,catalyzes the insertion of ferrous iron intoprotoporphyrin IX, the eighth and final step inthe heme biosynthetic pathway 0.000240.00455&radic S000005827RAX1YOR301WverifiedProtein involved in bud site selection during bipolar budding;localization requires Rax2p; has similarity tomembers of the insulin-related peptidesuperfamily 0.000240.00455 S000004839TMA29YMR226CverifiedNADP(+)-dependent dehydrogenase; acts on serine,L-allo-threonine, and other 3-hydroxy acids;green fluorescent protein fusion proteinlocalizes to the cytoplasm and nucleus; mayinteract with ribosomes, based onco-purification experiments 0.000240.00455&radic S000004865YMR252CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene 0.000240.00455&radic&radic S000000072CDC15YAR019CverifiedProtein kinase of the Mitotic Exit Network that is localized tothe spindle pole bodies at late anaphase;promotes mitotic exit by directly switching onthe kinase activity of Dbf2p 0.000240.00455&radic S000004180MMR1YLR190WverifiedPhosphorylated protein of the mitochondrial outer membrane,localizes only to mitochondria of the bud;interacts with Myo2p to mediate mitochondrialdistribution to buds; mRNA is targeted to thebud via the transport system involving She2p 0.000240.00455&radic S000113553YDR374W-AUncharacterizedPutative protein of unknown function 0.000240.00455 S000002144YAR066WUncharacterizedHypothetical protein 0.000240.00455 S000001145SBE22YHR103WverifiedProtein involved in the transport of cell wall components fromthe Golgi to the cell surface; similar instructure and functionally redundant withSbe2p; involved in bud growth 0.000240.00455&radic S000005234RFC3YNL290WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon 0.000240.00455&radic S000005671PNO1YOR145CverifiedEssential nucleolar protein required for pre-18S rRNAprocessing, interacts with Dim1p, an 18S rRNAdimethyltransferase, and also with Nob1p, whichis involved in proteasome biogenesis; containsa KH domain 0.000240.00455 S000003582YJL046WUncharacterizedPutative protein of unknown function, predicted to encode a lipoate-protein ligase A family member; deletion mutant has a respiratory growth defect 0.000240.00455 S000002542YCF1YDR135CverifiedVacuolar glutathione S-conjugate transporter of the ATP-bindingcassette family, has a role in detoxifyingmetals such as cadmium, mercury, and arsenite;also transports unconjugated bilirubin; similarto human cystic fibrosis protein CFTR 0.000240.00455&radic&radic S000002757YPS7YDR349CverifiedPutative GPI-anchored aspartic protease, located in thecytoplasm and endoplasmic reticulum 0.000240.00455&radic&radic S000002591PLP1YDR183WverifiedProtein with a possible role in folding of beta-tubulin; hassimilarity to phosducins, which are GTPaseinhibitors 0.000240.0045&radic S000004175RPL37AYLR185WverifiedProtein component of the large (60S) ribosomal subunit, hassimilarity to Rpl37Bp and to rat L37 ribosomalprotein 0.000240.0045&radic S000000368ARL1YBR164CverifiedSoluble GTPase with a role in regulation of membrane traffic;regulates potassium influx; G protein of theRas superfamily, similar to ADP-ribosylationfactor 0.000240.0045 S000005183LAP3YNL239WverifiedAminopeptidase of cysteine protease family, has a DNA bindingactivity and acts as bleomycin hydrolase invitro; transcription is regulated by galactosevia Gal4p 0.000240.0045 S000002871STP1YDR463WverifiedTranscription factor, activated by proteolytic processing inresponse to signals from the SPS sensor systemfor external amino acids; activatestranscription of amino acid permease genes andmay have a role in tRNA processing 0.000240.0045 S000003029DUO1YGL061CverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; is transferred to thekinetochore prior to mitosis 0.000240.0045&radic S000001567HOT13YKL084WverifiedMitochondrial intermembrane space protein, first component of apathway mediating assembly of small TIM(Translocase of the Inner Membrane) complexeswhich escort hydrophobic inner membraneproteins en route to the TIM22 complex 0.000240.0045 S000005237MSB3YNL293WverifiedGTPase-activating protein for Sec4p and several other RabGTPases, regulates exocytosis via its action onSec4p, also required for proper actinorganization; similar to Msb4p; both Msb3p andMsb4p localize to sites of polarized growth 0.000240.0045 S000004906GOT1YMR292WverifiedEvolutionarily conserved non-essential protein present in earlyGolgi cisternae that may be involved inER-Golgi transport at a step after vesicletethering to Golgi membranes, exhibits membranetopology similar to that of Sft2p 0.000240.0045&radic S000004811CIK1YMR198WverifiedKinesin-associated protein required for both karyogamy andmitotic spindle organization, interacts stablyand specifically with Kar3p and may function totarget this kinesin to a specific cellularrole; has similarity to Vik1p 0.000240.0045 S000004327NUP2YLR335WverifiedProtein involved in nucleocytoplasmic transport, binds toeither the nucleoplasmic or cytoplasmic facesof the nuclear pore complex depending onRan-GTP levels; also has a role in chromatinorganization 0.000240.0045&radic S000000964RAD4YER162CverifiedProtein that recognizes and binds damaged DNA (with Rad23p)during nucleotide excision repair; subunit ofNuclear Excision Repair Factor 2 (NEF2);homolog of human XPC protein 0.000240.0045 S000001138HXT5YHR096CverifiedHexose transporter with moderate affinity for glucose, inducedin the presence of non-fermentable carbonsources, induced by a decrease in growth rate,contains an extended N-terminal domain relativeto other HXTs 0.000240.0045&radic S000001505CDC16YKL022CverifiedSubunit of the anaphase-promoting complex/cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition; required forsporulation 0.000240.0045&radic S000004255NEJ1YLR265CverifiedProtein involved in regulation of nonhomologous end joining;repressed by MAT heterozygosity; associateswith Lif1p and regulates its cellulardistribution 0.000240.0045&radic&radic S000005278SNO2YNL334CverifiedProtein of unknown function, nearly identical to Sno3p;expression is induced before the diauxic shiftand also in the absence of thiamin 0.000240.00442 S000000416NGR1YBR212WverifiedRNA binding protein that negatively regulates growth rate;interacts with the 3' UTR of the mitochondrialporin (POR1) mRNA and enhances its degradation;overexpression impairs mitochondrial function;expressed in stationary phase 0.000240.00442&radic&radic S000001616YKL133CUncharacterizedHypothetical protein 0.000240.00442 S000000187MAP2YBL091CverifiedMethionine aminopeptidase, catalyzes the cotranslationalremoval of N-terminal methionine from nascentpolypeptides; function is partially redundantwith that of Map1p 0.000240.00442&radic&radic S000001510YKL027WVerifiedProtein of unknown function, localized to the mitochondrial outer membrane 0.000240.00442&radic S000005591CYT1YOR065WverifiedCytochrome c1, component of the mitochondrial respiratorychain; expression is regulated by theheme-activated, glucose-repressedHap2p/3p/4p/5p CCAAT-binding complex 0.000240.00442&radic&radic S000006073RRD2YPL152WverifiedActivator of the phosphotyrosyl phosphatase activity of PP2A;regulates G1 phase progression, theosmoresponse and microtubule dynamics;implicated in the spindle assembly check;subunit of the Tap42p-Pph21p-Rrd2p complex 0.000240.00442&radic S000005859VMA4YOR332WverifiedSubunit E of the eight-subunit V1 peripheral membrane domain ofthe vacuolar H+-ATPase (V-ATPase), anelectrogenic proton pump found throughout theendomembrane system; required for the V1 domainto assemble onto the vacuolar membrane 0.000240.00442&radic&radic S000001491LAC1YKL008CverifiedCeramide synthase component, involved in synthesis of ceramidefrom C26(acyl)-coenzyme A anddihydrosphingosine or phytosphingosine,functionally equivalent to Lag1p 0.000240.00442 S000001929QCR6YFR033CverifiedSubunit 6 of the ubiquinol cytochrome-c reductase complex,which is a component of the mitochondrial innermembrane electron transport chain; highlyacidic protein; required for maturation ofcytochrome c1 0.000240.00442&radic S000001181SPS100YHR139CverifiedProtein required for spore wall maturation; expressed duringsporulation; may be a component of the sporewall 0.000240.00442&radic S000006262YMC1YPR058WverifiedPutative mitochondrial inner membrane transporter, member ofthe mitochondrial carrier (MCF) family; theauthentic, non-tagged protein is detected inhighly purified mitochondria in high-throughputstudies 0.000240.00442 S000000115APN2YBL019WverifiedClass II abasic (AP) endonuclease involved in repair of DNAdamage; homolog of human HAP1 and E. coliexoIII 0.000240.00442&radic S000004916ATM1YMR301CverifiedMitochondrial inner membrane transporter, exportsmitochondrially synthesized precursors ofiron-sulfur (Fe/S) clusters to the cytosol;member of the ATP-binding cassette (ABC)transporter family 0.000240.00442&radic S000000688MSH3YCR092CverifiedMismatch repair protein, forms dimers with Msh2p that mediaterepair of insertion or deletion mutations andremoval of nonhomologous DNA ends, contains aPCNA (Pol30p) binding motif required for genomestability 0.000240.00438&radic S000004001LOT6YLR011WverifiedPutative NADPH-dependent FMN reductase with strong ferricyanidereductase activity in vitro; gene expressionincreases in cultures shifted to a lowertemperature 0.000240.00438&radic S000002891KRE2YDR483WverifiedAlpha1,2-mannosyltransferase of the Golgi involved in proteinmannosylation 0.000240.00438 S000006204YRF1-7YPL283CverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p 0.000240.00438 S000001162MSH1YHR120WverifiedDNA-binding protein of the mitochondria involved in repair ofmitochondrial DNA, has ATPase activity andbinds to DNA mismatches; has homology to E.coli MutS; transcription is induced duringmeiosis 0.000240.00438&radic S000003576NUP192YJL039CverifiedEssential structural subunit of the nuclear pore complex (NPC),localizes to the nuclear periphery of nuclearpores, homologous to human p205 0.000240.00438 S000002506BMH2YDR099Wverified14-3-3 protein, minor isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others 0.000240.00438&radic&radic S000003698JJJ2YJL162CuncharacterizedProtein of unknown function, contains a J-domain, which is aregion with homology to the E. coli DnaJprotein 0.000240.00438 S000000127SHE1YBL031WverifiedCytoskeletal protein of unknown function; overexpression causesgrowth arrest 0.000240.00438&radic S000001002YHL010CUncharacterizedPutative protein of unknown function, contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences 0.000240.00438&radic S000087085YBR201C-AUncharacterizedPutative protein of unknown function 0.000240.00438 S000000545GLK1YCL040WverifiedGlucokinase, catalyzes the phosphorylation of glucose at C6 inthe first irreversible step of glucosemetabolism; one of three glucosephosphorylating enzymes; expression regulatedby non-fermentable carbon sources 0.000240.00438&radic S000000291RFC5YBR087WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon 0.000240.00438 S000000534BIK1YCL029CverifiedMicrotubule-associated protein, component of the interfacebetween microtubules and kinetochore, involvedin sister chromatid separation; essential inpolyploid cells but not in haploid or diploidcells; ortholog of mammalian CLIP-170 0.000240.00438&radic&radic S000005250MRPS18YNL306WverifiedMitochondrial ribosomal protein of the small subunit; essentialfor viability, unlike most other mitoribosomalproteins 0.000240.00438&radic S000003173POX1YGL205WverifiedFatty-acyl coenzyme A oxidase, involved in the fatty acidbeta-oxidation pathway; localized to theperoxisomal matrix 0.000240.00438 S000004044OSW2YLR054CuncharacterizedProtein of unknown function proposed to be involved in theassembly of the spore wall 0.000240.0043 S000001814YKR106WUncharacterizedProtein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YCL073C 0.000240.0043 S000004111YPS3YLR121CverifiedAspartic protease, attached to the plasma membrane via aglycosylphosphatidylinositol (GPI) anchor 0.000240.0043&radic S000005765ABP140YOR239WverifiedNonessential protein that binds actin filaments and localizesto actin patches and cables, has similarity toS-adenosylmethionine (AdoMet)-dependentmethyltransferases 0.000240.0043&radic&radic S000000547YCL042WUncharacterizedHypothetical protein 0.000240.0043&radic S000000139ECM13YBL043WverifiedNon-essential protein of unknown function 0.000240.0043 S000005699DCS2YOR173WverifiedNon-essential, stress induced regulatory protein containing aHIT (histidine triad) motif; modulatesm7G-oligoribonucleotide metabolism; inhibitsDcs1p; regulated by Msn2p, Msn4p, and theRas-cAMP-cAPK signaling pathway, similar toDcs1p. 0.000240.0043&radic S000028827YGR035W-AUncharacterizedPutative protein of unknown function 0.000240.0043 S000005368COQ10YOL008WverifiedCoenzyme Q binding protein, required for function of coenzyme Qin respiration by functioning in the deliveryof Q6 to its proper location forelectron transport, START domain protein withhomologs in bacteria and eukaryotes 0.000240.0043&radic S000002294RDI1YDL135CverifiedRho GDP dissociation inhibitor involved in the localization andregulation of Cdc42p 0.000240.0043 S000004241SYM1YLR251WuncharacterizedProtein required for ethanol metabolism; induced by heat shockand localized to the inner mitochondrialmembrane; homologous to mammalian peroxisomalmembrane protein Mpv17 0.000240.0043 S000004543CPR3YML078WverifiedMitochondrial peptidyl-prolyl cis-trans isomerase(cyclophilin), catalyzes the cis-transisomerization of peptide bonds N-terminal toproline residues; involved in protein refoldingafter import into mitochondria 0.000240.0043 S000005655YOR129CVerifiedPutative component of the outer plaque of the spindle pole body; may be involved in cation homeostasis or multidrug resistance 0.000240.0043&radic S000001136HXT1YHR094CverifiedLow-affinity glucose transporter of the major facilitatorsuperfamily, expression is induced by Hxk2p inthe presence of glucose and repressed by Rgt1pwhen glucose is limiting 0.000240.0043 S000002831CAD1YDR423CverifiedAP-1-like bZIP transcriptional activator involved in multiplestress responses, iron metabolism, andpleiotropic drug resistance; controls a set ofgenes involved in stabilizing proteins, bindsconsensus sequence TTACTAA; 5' UTR containsuORFs 0.000240.0043&radic S000001318VHR1YIL056WuncharacterizedTranscriptional activator, required for the vitaminH-responsive element (VHRE) mediated inductionof VHT1 (Vitamin H transporter) and BIO5(biotin biosynthesis intermediate transporter)in response to low biotin concentrations 0.000240.0043 S000001539TMA19YKL056CverifiedProtein that associates with ribosomes; homolog oftranslationally controlled tumor protein; greenfluorescent protein (GFP)-fusion proteinlocalizes to the cytoplasm and relocates to themitochondrial outer surface upon oxidativestress 0.000240.0043&radic S000003247YGR015CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion 0.000240.0043&radic S000004223EST1YLR233CverifiedTLC1 RNA-associated factor involved in telomere lengthregulation as the recruitment subunit of thetelomerase holoenzyme, has a possible role inactivating Est2p-TLC1-RNA bound to the telomere 0.000240.0043&radic S000002337DLD2YDL178WverifiedD-lactate dehydrogenase, located in the mitochondrial matrix 0.000240.0043 S000001074YHR032WUncharacterizedPutative protein of unknown function 0.000240.0043 S000004079ALT1YLR089CuncharacterizedPutative alanine transaminase (glutamic pyruvic transaminase);the authentic, non-tagged protein is detectedin highly purified mitochondria inhigh-throughput studies 0.000240.0043&radic&radic S000001765RPS21AYKR057WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps21Bp and has similarity to ratS21 ribosomal protein 0.000240.0043 S000004757SWP1YMR149WverifiedDelta subunit of the oligosaccharyl transferase glycoproteincomplex, which is required for N-linkedglycosylation of proteins in the endoplasmicreticulum 0.000240.0043 S000003439YGR207CVerifiedProtein of unknown function; homolog of mammalian electron transfer flavoprotein complex subunit ETF-beta; interacts with frataxin (Yfh1p) 0.000240.00428 S000001646PIR3YKL163WverifiedO-glycosylated covalently-bound cell wall protein required forcell wall stability; expression is cell cycleregulated, peaking in M/G1 and also subject toregulation by the cell integrity pathway 0.000240.00428 S000004214YLR224WUncharacterizedF-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene 0.000240.00428&radic S000003432ELP2YGR200CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;target of Kluyveromyces lactis zymocin 0.000240.00428&radic S000004388VPS33YLR396CverifiedATP-binding protein that is a subunit of the homotypic vacuolefusion and vacuole protein sorting (HOPS)complex; essential for membrane docking andfusion at both the Golgi-to-endosome andendosome-to-vacuole stages of protein transport 0.000240.00428&radic S000005521PAU20YOL161CuncharacterizedHypothetical protein 0.000240.00428 S000002521YDR114CUncharacterizedPutative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium 0.000240.00428&radic&radic S000005245RPL18BYNL301CverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl18Ap and has similarity to ratL18 ribosomal protein 0.000240.00428 S000004008POM34YLR018CverifiedIntegral membrane protein of the nuclear pore; has an importantrole in maintaining the architecture of thepore complex 0.000240.00428&radic S000000537STE50YCL032WverifiedProtein involved in mating response, invasive/filamentousgrowth, and osmotolerance, acts as an adaptorthat links G protein-associated Cdc42p-Ste20pcomplex to the effector Ste11p to modulatesignal transduction 0.000240.00428&radic&radic S000005797FSF1YOR271CuncharacterizedPutative protein, predicted by computational methods to be analpha-isopropylmalate carrier; the authentic,non-tagged protein is detected in highlypurified mitochondria in high-throughputstudies 0.000240.00428 S000003968RPL8BYLL045CverifiedRibosomal protein L4 of the large (60S) ribosomal subunit,nearly identical to Rpl8Ap and has similarityto rat L7a ribosomal protein; mutation resultsin decreased amounts of free 60S subunits 0.000240.00428&radic S000001766GLG1YKR058WverifiedSelf-glucosylating initiator of glycogen synthesis, alsoglucosylates n-dodecyl-beta-D-maltoside;similar to mammalian glycogenin 0.000240.00428&radic S000004179ATG26YLR189CverifiedUDP-glucose:sterol glucosyltransferase, conserved enzymeinvolved in synthesis of sterol glucosidemembrane lipids, involved in autophagy 0.000240.00428&radic S000000784PCM1YEL058WverifiedEssential N-acetylglucosamine-phosphate mutase, ahexosephosphate mutase involved in thebiosynthesis of chitin 0.000240.00428&radic S000003267YGR035CUncharacterizedPutative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance 0.000240.00428&radic S000001673CNB1YKL190WverifiedCalcineurin B; the regulatory subunit of calcineurin, aCa++/calmodulin-regulated protein phosphatasewhich regulates Crz1p (a stress-responsetranscription factor), the other calcineurinsubunit is encoded by CNA1 and/or CMP1 0.000240.00428&radic S000003903YJR142WUncharacterizedPutative protein of unknown function 0.000240.00428 S000002593YDR185CUncharacterizedMitochondrial protein of unknown function; has similarity to Ups1p, which is involved in regulation of alternative topogenesis of the dynamin-related GTPase Mgm1p 0.000240.00428&radic&radic S000004419MAG2YLR427WuncharacterizedDNA-3-methyladenine glycosidase II that catalyzes of thehydrolysis of alkylated DNA 0.000240.00428 S000004895AEP2YMR282CverifiedMitochondrial protein, likely involved in translation of themitochondrial OLI1 mRNA; exhibits geneticinteraction with the OLI1 mRNA 5'-untranslatedleader 0.000240.00428&radic&radic S000004396YLR404WUncharacterizedPutative protein of unknown function; may be an integral membrane protein; YLR404W is not an essential gene 0.000240.00418&radic S000005013RPL16BYNL069CverifiedN-terminally acetylated protein component of the large (60S)ribosomal subunit, binds to 5.8 S rRNA; hassimilarity to Rpl16Ap, E. coli L13 and rat L13aribosomal proteins; transcriptionally regulatedby Rap1p 0.000240.00418 S000004011IRC25YLR021WuncharacterizedPutative protein of unknown function; mutant accumulatesunusually high amounts of dityrosine in thesoluble fraction though spores appearwild-type; YLR021W is not an essential gene;null mutant displays increased levels ofspontaneous Rad52 foci 0.000240.00418&radic&radic S000004490TSA1YML028WverifiedUbiquitous housekeeping thioredoxin peroxidase, reducesreactive oxygen, nitrogen and sulfur speciesusing thioredoxin as hydrogen donor; mediatesredox regulation of the nuclear localization ofYap1p; deletion results in mutator phenotype 0.000240.00418&radic&radic S000003856SFC1YJR095WverifiedMitochondrial succinate-fumarate transporter, transportssuccinate into and fumarate out of themitochondrion; required for ethanol and acetateutilization 0.000240.00418 S000005446ADH1YOL086CverifiedAlcohol dehydrogenase, fermentative isozyme active as homo- orheterotetramers; required for the reduction ofacetaldehyde to ethanol, the last step in theglycolytic pathway 0.000240.00418 S000005905YOR378WUncharacterizedHypothetical protein 0.000240.00418 S000001713YKR005CUncharacterizedPutative protein of unknown function 0.000240.00418&radic S000005213BSC4YNL269WverifiedProtein of unknown function, ORF exhibits genomic organizationcompatible with a translationalreadthrough-dependent mode of expression;readthrough is increased upon depletion ofSup35p 0.000240.00418&radic&radic S000000694HMRA1YCR097WverifiedSilenced copy of a1 at HMR; homeobox corepressor that interactswith Alpha2p to repress haploid-specific genetranscription in diploid cells 0.000240.00418 S000004488RPS18BYML026CverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps18Ap and has similarity to E.coli S13 and rat S18 ribosomal proteins 0.000240.00418 S000005786GCD1YOR260WverifiedGamma subunit of the translation initiation factor eIF2B, theguanine-nucleotide exchange factor for eIF2;activity subsequently regulated byphosphorylated eIF2; first identified as anegative regulator of GCN4 expression 0.000240.00418 S000002780VPS74YDR372CverifiedNon-essential protein of unknown function involved in vacuolarprotein sorting; belongs to a family ofcytosolic Golgi-associated proteins suggestingthat it may play a role in secretion; alsodetected in the nucleus 0.000240.00418 S000005637YOR111WUncharacterizedHypothetical protein 0.000240.00418&radic&radic S000000516SGF29YCL010CverifiedSaGa associated Factor 29kDa; Probable 29kKDa Subunit of SAGAhistone acetyltransferase complex 0.000240.00418&radic S000001943BNA6YFR047CverifiedQuinolinate phosphoribosyl transferase, required forbiosynthesis of nicotinic acid from tryptophanvia kynurenine pathway 0.000240.00418&radic&radic S000001640APE2YKL157WverifiedZinc-dependent metallopeptidase yscII, may have a role inobtaining leucine from dipeptide substrates;sequence coordinates have changed since RT-PCRanalysis showed that the adjacent ORF YKL158Wcomprises the 5' exon of APE2/YKL157W 0.000240.00418&radic&radic S000000556LRE1YCL051WverifiedProtein involved in control of cell wall structure and stressresponse; inhibits Cbk1p protein kinaseactivity; overproduction confers resistance tocell-wall degrading enzymes 0.000240.00418&radic S000002694YDR286CUncharacterizedHypothetical protein 0.000240.00418&radic S000028816YBR196C-BUncharacterizedPutative protein of unknown function; identified by expression profiling and mass spectrometry 0.000240.00418 S000003302ROM1YGR070WverifiedGDP/GTP exchange protein (GEP) for Rho1p; mutations aresynthetically lethal with mutations in rom2,which also encodes a GEP 0.000240.00418 S000006289YPR085CUncharacterizedProtein required for cell viability 0.000240.00418 S000003548RPC17YJL011CverifiedRNA polymerase III subunit C17; physically interacts with C31,C11, and TFIIIB70; may be involved in therecruitment of pol III by the preinitiationcomplex 0.000240.00418 S000002884YDR476CUncharacterizedHypothetical protein 0.000240.00418 S000000001TFC3YAL001CverifiedLargest of six subunits of the RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part of theTauB domain of TFIIIC that binds DNA at theBoxB promoter sites of tRNA and similar genes;cooperates with Tfc6p in DNA binding 0.000240.00418&radic S000002193GPR1YDL035CverifiedPlasma membrane G protein coupled receptor (GPCR) thatinteracts with the heterotrimeric G proteinalpha subunit, Gpa2p, and with Plc1p; sensorthat integrates nutritional signals with themodulation of cell fate via PKA and cAMPsynthesis 0.000240.00418 S000000459YBR255WUncharacterizedProtein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.000240.00412 S000002528DPB4YDR121WverifiedShared subunit of DNA polymerase epsilon and of ISW2/yCHRACchromatin accessibility complex; involved inboth chromosomal DNA replication and ininheritance of telomeric silencing 0.000240.00412&radic S000000884UTP7YER082CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.000240.00412&radic S000004308TAD3YLR316CverifiedSubunit of tRNA-specific adenosine-34 deaminase, forms aheterodimer with Tad2p that converts adenosineto inosine at the wobble position of severaltRNAs 0.000240.00412&radic S000000837EDC2YER035WverifiedRNA-binding protein, activates mRNA decapping directly bybinding to the mRNA substrate and enhancing theactivity of the decapping proteins Dcp1p andDcp2p 0.000240.00412 S000028520YDL160C-AUncharacterizedPutative protein of unknown function 0.000240.00412 S000000596MRPL32YCR003WverifiedMitochondrial ribosomal protein of the large subunit 0.000240.00412&radic S000004215YLR225CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene 0.000240.00412 S000004010YEH2YLR020CverifiedSteryl ester hydrolase, catalyzes steryl ester hydrolysis atthe plasma membrane; involved in sterolmetabolism 0.000240.00412&radic&radic S000000768GDA1YEL042WverifiedGuanosine diphosphatase located in the Golgi, involved in thetransport of GDP-mannose into the Golgi lumenby converting GDP to GMP after mannose istransferred its substrate 0.000240.00412&radic S000006008YDC1YPL087WverifiedAlkaline dihydroceramidase, involved in sphingolipidmetabolism; preferentially hydrolyzesdihydroceramide to a free fatty acid anddihydrosphingosine; has a minor reverseactivity 0.000240.00412 S000004128NHA1YLR138WverifiedNa+/H+ antiporter involved in sodium and potassium effluxthrough the plasma membrane; required foralkali cation tolerance at acidic pH 0.000240.00412 S000001621MRPL31YKL138CverifiedMitochondrial ribosomal protein of the large subunit 0.000240.00412&radic S000028566YLR159C-AUncharacterizedPutative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-5 0.000240.00412 S000005373HRD1YOL013CverifiedUbiquitin-protein ligase required for endoplasmicreticulum-associated degradation (ERAD) ofmisfolded proteins; genetically linked to theunfolded protein response (UPR); regulatedthrough association with Hrd3p; contains an H2ring finger 0.000240.00412&radic&radic S000003364PHB1YGR132CverifiedSubunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDaring-shaped inner mitochondrial membranechaperone that stabilizes newly synthesizedproteins; determinant of replicative life span;involved in mitochondrial segregation 0.000240.00412 S000003765APL1YJR005WverifiedBeta-adaptin, large subunit of the clathrin associ