Yfunc lets you browse current and predicted gene functions in yeast

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Prediction of GO:0016076 "snRNA catabolism"

GO branch: BP
Number of currently annotated genes: 4

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest Ho:S000001341Ho:S000002334IPR002058PR00939Giaever:5-fluorouracil_38.5uMTAP:129PF00098PF03828PF01909IPR002934 S000005475PAP2YOL115WverifiedCatalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), anuclear poly (A) polymerase complex involved inRNA quality control; catalyzes polyadenylationof unmodified tRNAs, and snoRNA and rRNAprecursors; disputed role as a DNA polymerase &radic0.24160.97297&radic&radic&radic&radic S000005243TRF5YNL299WverifiedPoly (A) polymerase involved in nuclear RNA quality controlbased on: homology with Trf4p, geneticinteractions with TRF4 mutants, physicalinteraction with Mtr4p (TRAMP subunit), and bydirect assay; disputed role as a sigma DNApolymerase &radic0.09410.74689&radic&radic&radic&radic&radic S000001341AIR1YIL079CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p to regulate methylationof Npl3p, which modulates Npl3p function inmRNA processing and export; has similarity toAir2p &radic0.059520.63653&radic&radic&radic S000002334AIR2YDL175CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p; may regulatemethylation of Npl3p, which modulates Npl3pfunction in mRNA processing and export; hassimilarity to Air1p &radic0.05470.62072&radic&radic&radic&radic S000001710PAP1YKR002WverifiedPoly(A) polymerase, one of three factors required for mRNA3'-end polyadenylation, forms multiproteincomplex with polyadenylation factor I (PF I),also required for mRNA nuclear export; may alsopolyadenylate rRNAs 0.006550.27152&radic&radic S000002495SLU7YDR088CverifiedRNA splicing factor, required for ATP-independent portion of2nd catalytic step of spliceosomal RNAsplicing; interacts with Prp18p; contains zincknuckle domain 0.004870.21557&radic&radic S000005199GIS2YNL255CverifiedProtein with seven cysteine-rich CCHC zinc-finger motifs,similar to human CNBP, proposed to be involvedin the RAS/cAMP signaling pathway 0.004580.20432&radic&radic S000004106MSL5YLR116WverifiedComponent of the commitment complex, which defines the firststep in the splicing pathway; essential proteinthat interacts with Mud2p and Prp40p, forming abridge between the intron ends; also involvedin nuclear retention of pre-mRNA 0.004350.19421&radic&radic S000000939YER137CUncharacterizedHypothetical protein 0.003230.14936&radic S000006311YTH1YPR107CverifiedEssential RNA-binding component of cleavage and polyadenylationfactor, contains five zinc fingers; requiredfor pre-mRNA 3'-end processing andpolyadenylation 0.002460.11754 S000001542MPE1YKL059CverifiedEssential conserved subunit of CPF (cleavage andpolyadenylation factor), plays a role in 3' endformation of mRNA via the specific cleavage andpolyadenylation of pre-mRNA, contains aputative RNA-binding zinc knuckle motif 0.002430.1164 S000003586MTR4YJL050WverifiedDead-box family ATP dependent helicase required for mRNA exportfrom the nucleus; co-factor of the exosomecomplex, required for 3' end formation of 5.8SrRNA 0.001110.05371 S000002840NPL3YDR432WverifiedRNA-binding protein that carries poly(A)+ mRNA from the nucleusinto the cytoplasm; phosphorylation by Sky1p inthe cytoplasm may promote release of mRNAs 0.000720.03347&radic S000005206POL2YNL262WverifiedCatalytic subunit of DNA polymerase epsilon, one of the majorchromosomal DNA replication polymerasescharacterized by processivity and proofreadingexonuclease activity; also involved in DNAsynthesis during DNA repair 0.000540.02579 S000005366TOP1YOL006CverifiedTopoisomerase I, nuclear enzyme that relieves torsional strainin DNA by cleaving and re-sealing thephosphodiester backbone; relaxes bothpositively and negatively supercoiled DNA;functions in replication, transcription, andrecombination 0.000460.01976 S000000238HMT1YBR034CverifiedNuclear SAM-dependent mono- and asymmetric argininedimethylating methyltransferase that modifieshnRNPs, including Npl3p and Hrp1p, thusfacilitating nuclear export of these proteins;required for viability of npl3 mutants 0.000430.01861 S000004029RIC1YLR039CverifiedProtein involved in retrograde transport to the cis-Golginetwork; forms heterodimer with Rgp1p that actsas a GTP exchange factor for Ypt6p; involved intranscription of rRNA and ribosomal proteingenes 0.000280.00706 S000006379DPB2YPR175WverifiedSecond largest subunit of DNA polymerase II (DNA polymeraseepsilon), required for normal yeast chromosomalreplication; expression peaks at the G1/S phaseboundary; potential Cdc28p substrate 0.000260.00555 S000004577ZDS2YML109WverifiedProtein that interacts with silencing proteins at the telomere,involved in transcriptional silencing; paralogof Zds1p 0.000260.00555 S000005730DED1YOR204WverifiedATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, requiredfor translation initiation of all yeast mRNAs;mutations in human DEAD-box DBY are a frequentcause of male infertility 0.000250.00479 S000001129YHR087WVerifiedProtein involved in RNA metabolism, one of two yeast homologs (with Sdo1p/Ylr022cp) of the human protein SBDS responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome, also conserved in Archaea 0.000210.00287 S000005056DBP2YNL112WverifiedEssential ATP-dependent RNA helicase of the DEAD-box proteinfamily, involved in nonsense-mediated mRNAdecay and rRNA processing 0.00020.00278 S000004349RSC2YLR357WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; involvedin telomere maintenance 0.00020.00278 S000004093CDC45YLR103CverifiedDNA replication initiation factor; recruited to MCM pre-RCcomplexes at replication origins; promotesrelease of MCM from Mcm10p, recruits elongationmachinery; mutants in human homolog may causevelocardiofacial and DiGeorge syndromes 0.00020.00278 S000005028END3YNL084CverifiedEH domain-containing protein involved in endocytosis, actincytoskeletal organization and cell wallmorphogenesis; forms a complex with Sla1p andPan1p 0.00020.00271 S000006305SNT309YPR101WverifiedComponent of NineTeen complex (NTC) containing Prp19p involvedin mRNA splicing, interacts physically andgenetically with Prp19p 0.00020.00271&radic S000000120NCL1YBL024WverifiedS-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase,methylates cytosine to m5C at several positionsin tRNAs and intron-containing pre-tRNAs;similar to Nop2p and human proliferationassociated nucleolar protein p120 0.00020.00271 S000004949HRB1YNL004WverifiedPoly(A+) RNA-binding protein, involved in the export of mRNAsfrom the nucleus to the cytoplasm; similar toGbp2p and Npl3p 0.00020.00271 S000004886ZDS1YMR273CverifiedProtein that interacts with silencing proteins at the telomere,involved in transcriptional silencing; has arole in localization of Bcy1p, a regulatorysubunit of protein kinase A; implicated in mRNAnuclear export 0.00020.00271 S000004172SWI6YLR182WverifiedTranscription cofactor, forms complexes with DNA-bindingproteins Swi4p and Mbp1p to regulatetranscription at the G1/S transition; involvedin meiotic gene expression; localizationregulated by phosphorylation; potential Cdc28psubstrate 0.00020.00271 S000004187SIK1YLR197WverifiedEssential evolutionarily-conserved nucleolar protein componentof the box C/D snoRNP complexes that direct2'-O-methylation of pre-rRNA during itsmaturation; overexpression causes spindleorientation defects 0.00020.00266 S000005667ARP8YOR141CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes 0.00020.00263 S000004181PEX13YLR191WverifiedIntegral peroxisomal membrane receptor for the PTS1 peroxisomalmatrix protein signal recognition factor Pex5p,required for the translocation of peroxisomalmatrix proteins, also interacts with Pex7p andPex14p, contains a C-terminal SH3 domain 0.000190.00257 S000004415ATG17YLR423CverifiedProtein that interacts with and is required for activation ofApg1p protein kinase; involved in autophagy butnot in the Cvt (cytoplasm to vacuole targeting)pathway 0.000190.00253 S000004732STO1YMR125WverifiedLarge subunit of the nuclear mRNA cap-binding protein complex,interacts with Npl3p to carry nuclear poly(A)+mRNA to cytoplasm; also involved in nuclearmRNA degradation and telomere maintenance;orthologous to mammalian CBP80 0.000190.00253&radic S000006067NOP53YPL146CverifiedNucleolar protein; involved in biogenesis of the 60S subunit ofthe ribosome; interacts with rRNA processingfactors Cbf5p and Nop2p; null mutant is viablebut growth is severely impaired 0.000190.00242 S000001886SMC1YFL008WverifiedSubunit of the multiprotein cohesin complex, essential proteininvolved in chromosome segregation and indouble-strand DNA break repair; SMC chromosomalATPase family member, binds DNA with apreference for DNA with secondary structure 0.000190.00242 S000002360TRM8YDL201WverifiedSubunit of a tRNA methyltransferase complex composed of Trm8pand Trm82p that catalyzes 7-methylguanosinemodification of tRNA 0.000180.00235 S000003797HUL4YJR036CverifiedProtein with similarity to hect domain E3 ubiquitin-proteinligases, not essential for viability 0.000180.00231 S000001906UBP6YFR010WverifiedUbiquitin-specific protease situated in the base subcomplex ofthe 26S proteasome, releases free ubiquitinfrom branched polyubiquitin chains; deletioncauses hypersensitivity to cycloheximide andother toxic compounds 0.000180.00231 S000004837MRE11YMR224CverifiedSubunit of a complex with Rad50p and Xrs2p (RMX complex) thatfunctions in repair of DNA double-strand breaksand in telomere stability, exhibits nucleaseactivity that appears to be required for RMXfunction; widely conserved 0.000170.00217 S000000435SWC5YBR231CuncharacterizedProtein of unknown function, component of the SWR1 complex,which exchanges histone variant H2AZ (Htz1p)for chromatin-bound histone H2A 0.000170.00214 S000000301VPS15YBR097WverifiedMyristoylated serine/threonine protein kinase involved invacuolar protein sorting; functions as amembrane-associated complex with Vps34p; activeform recruits Vps34p to the Golgi membrane;interacts with the GDP-bound form of Gpa1p 0.000170.00214 S000006111NAB3YPL190CverifiedSingle stranded DNA binding protein; acidic ribonucleoprotein;required for termination of non-poly(A)transcripts and efficient splicing; interactswith Nrd1p 0.000170.00213&radic S000004520IMD4YML056CverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 0.000170.00213 S000001508PAN3YKL025CverifiedEssential subunit of the Pan2p-Pan3p poly(A)-ribonucleasecomplex, which acts to control poly(A) taillength and regulate the stoichiometry andactivity of postreplication repair complexes 0.000160.00212 S000003397MRPS35YGR165WverifiedMitochondrial ribosomal protein of the small subunit 0.000160.00212 S000004363ROM2YLR371WverifiedGDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutationsare synthetically lethal with mutations inrom1, which also encodes a GEP 0.000160.00211 S000000322TEF2YBR118WverifiedTranslational elongation factor EF-1 alpha; also encoded byTEF1; functions in the binding reaction ofaminoacyl-tRNA (AA-tRNA) to ribosomes 0.000160.00211 S000006177CLN2YPL256CverifiedG1 cyclin involved in regulation of the cell cycle; activatesCdc28p kinase to promote the G1 to S phasetransition; late G1 specific expression dependson transcription factor complexes, MBF(Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) 0.000160.00209 S000005606DIA2YOR080WverifiedOrigin-binding F-box protein that forms an SCF ubiquitin ligasecomplex with Skp1p and Cdc53p; plays a role inDNA replication, involved in invasive andpseudohyphal growth 0.000160.00209 S000000968DNF1YER166WverifiedAminophospholipid translocase (flippase) that localizesprimarily to the plasma membrane; contributesto endocytosis, protein transport and cellpolarity; type 4 P-type ATPase 0.000160.00202 S000000744EAF5YEL018WuncharacterizedEsa1p-associated factor, subunit of the NuA4 acetyltransferasecomplex 0.000160.00202 S000003095SOH1YGL127CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; involved in telomeremaintenance; conserved with other metazoanMED31 subunits 0.000160.00202 S000004467ERG6YML008CverifiedDelta(24)-sterol C-methyltransferase, converts zymosterol tofecosterol in the ergosterol biosyntheticpathway by methylating position C-24; localizedto both lipid particles and mitochondrial outermembrane 0.000160.00202 S000005195NRD1YNL251CverifiedRNA-binding protein that interacts with the C-terminal domainof the RNA polymerase II large subunit(Rpo21p), required for transcriptiontermination and 3' end maturation ofnonpolyadenylated RNAs 0.000160.002&radic S000003406CBP4YGR174CverifiedMitochondrial protein required for assembly of ubiquinolcytochrome-c reductase complex (cytochrome bc1complex); interacts with Cbp3p and function ispartially redundant with that of Cbp3p 0.000150.00197 S000004312MMS22YLR320WverifiedProtein involved in resistance to ionizing radiation; acts withMms1p in a repair pathway that may be involvedin resolving replication intermediates orpreventing the damage caused by blockedreplication forks 0.000130.00182 S000000286UBC4YBR082CverifiedUbiquitin-conjugating enzyme that mediates degradation ofshort-lived and abnormal proteins; interactswith E3-CaM in ubiquitinating calmodulin;interacts with many SCF ubiquitin proteinligases; component of the cellular stressresponse 0.000140.00182 S000004329VRP1YLR337CverifiedProline-rich actin-associated protein involved in cytoskeletalorganization and cytokinesis; related tomammalian Wiskott-Aldrich syndrome protein(WASP)-interacting protein (WIP) 0.000130.00178 S000003054MAD1YGL086WverifiedCoiled-coil protein involved in the spindle-assemblycheckpoint; phosphorylated by Mps1p uponcheckpoint activation which leads to inhibitionof the activity of the anaphase promotingcomplex; forms a complex with Mad2p 0.000130.00176 S000005187SLA2YNL243WverifiedTransmembrane actin-binding protein involved in membranecytoskeleton assembly and cell polarization;adaptor protein that links actin to clathrinand endocytosis; present in the actin corticalpatch of the emerging bud tip; dimer in vivo 0.000130.00175 S000005923SNF8YPL002CverifiedComponent of the ESCRT-II complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; appears to be functionallyrelated to SNF7; involved in glucosederepression 0.000130.00174 S000005552BUB3YOR026WverifiedKinetochore checkpoint WD40 repeat protein that localizes tokinetochores during prophase and metaphase,delays anaphase in the presence of unattachedkinetochores; forms complexes with Mad1p-Bub1pand with Cdc20p, binds Mad2p and Mad3p 0.000130.00174 S000002545HPR1YDR138WverifiedSubunit of THO/TREX complexes that couple transcriptionelongation with mitotic recombination and withmRNA metabolism and export, subunit of an RNAPol II complex; regulates lifespan; involved intelomere maintenance; similar to Top1p 0.000130.00174 S000004409VPS36YLR417WverifiedComponent of the ESCRT-II complex; contains the GLUE (GRAM LikeUbiquitin binding in EAP45) domain which isinvolved in interactions with ESCRT-I andubiquitin-dependent sorting of proteins intothe endosome 0.000130.00174 S000005051YAF9YNL107WverifiedSubunit of both the NuA4 histone H4 acetyltransferase complexand the SWR1 complex, may function toantagonize silencing near telomeres; interactsdirectly with Swc4p, has homology to humanleukemogenic protein AF9, contains a YEATSdomain 0.000130.00174 S000004075ARP6YLR085CverifiedActin-related protein that binds nucleosomes; a component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.000120.00173 S000002160NHP10YDL002CverifiedProtein related to mammalian high mobility group proteins;likely component of the INO80 complex, which isan ATP-dependent chromatin-remodeling complex 0.000120.00173 S000000913SWI4YER111CverifiedDNA binding component of the SBF complex (Swi4p-Swi6p), atranscriptional activator that in concert withMBF (Mbp1-Swi6p) regulates late G1-specifictranscription of targets including cyclins andgenes required for DNA synthesis and repair 0.000120.00173 S000000631RRP43YCR035CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp41p, Rrp42p,Rrp4p and Dis3p; required for efficientmaturation of 5.8S, 18S and 25S rRNA 0.000120.00173 S000001927SMC2YFR031CverifiedComponent of the condensin complex, essential SMC chromosomalATPase family member that forms a complex withSmc4p to form the active ATPase; Smc2p/Smc4pcomplex binds DNA, possibly in the cleft formedby the coiled-coil of the folded dimer 0.000120.00173 S000000770IES6YEL044WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.000120.00173 S000000682CSM1YCR086WverifiedNucleolar protein that forms a complex with Lrs4p which bindsMam1p at kinetochores during meiosis I tomediate accurate chromosome segregation, may beinvolved in premeiotic DNA replication;possible role in telomere maintenance 0.000120.00172 S000005143GCR2YNL199CverifiedTranscriptional activator of genes involved in glycolysis;interacts and functions with the DNA-bindingprotein Gcr1p 0.000120.00172 S000005169CNM67YNL225CverifiedComponent of the spindle pole body outer plaque; required forspindle orientation and mitotic nuclearmigration 0.000120.00171 S000003288RSC1YGR056WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; containstwo essential bromodomains, a bromo-adjacenthomology (BAH) domain, and an AT hook 0.000120.0017 S000000122LSM2YBL026WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.000120.0017 S000001596RAD27YKL113Cverified5' to 3' exonuclease, 5' flap endonuclease, required forOkazaki fragment processing and maturation aswell as for long-patch base-excision repair;member of the S. pombe RAD2/FEN1 family 0.000120.0017 S000000673PAT1YCR077CverifiedTopoisomerase II-associated deadenylation-dependentmRNA-decapping factor; also required forfaithful chromosome transmission, maintenanceof rDNA locus stability, and protection of mRNA3'-UTRs from trimming; functionally linked toPab1p 0.000120.0017 S000003863VPS25YJR102CverifiedComponent of the ESCRT-II complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome 0.000120.00169 S000005831ISW2YOR304WverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPasecomponent that, with Itc1p, forms a complexrequired for repression of a-specific genes,INO1, and early meiotic genes during mitoticgrowth 0.000120.00169 S000004683CTF18YMR078CverifiedSubunit of a complex with Ctf8p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion; may have overlappingfunctions with Rad24p in the DNA damagereplication checkpoint 0.000120.00169 S000003651ASF1YJL115WverifiedNucleosome assembly factor, involved in chromatin assembly anddisassembly, anti-silencing protein that causesderepression of silent loci when overexpressed 0.000120.00169 S000002536SAC6YDR129CverifiedFimbrin, actin-bundling protein; cooperates with Scp1p(calponin/transgelin) in the organization andmaintenance of the actin cytoskeleton 0.000120.00169 S000003818CDC8YJR057WverifiedThymidylate and uridylate kinase, functions in de novobiosynthesis of pyrimidinedeoxyribonucleotides; converts dTMP to dTDP anddUMP to dUTP; essential for mitotic and meioticDNA replication; homologous to S. pombe Tmp1p 0.000120.00169 S000003626DPB11YJL090CverifiedEssential BRCT repeat protein, required on the prereplicativecomplex at replication origins for loading DNApolymerases to initiate DNA synthesis, alsorequired for S/M checkpoint control 0.000120.00167 S000001756NAP1YKR048CverifiedProtein that interacts with mitotic cyclin Clb2p; required forthe regulation of microtubule dynamics duringmitosis; controls bud morphogenesis; involvedin the transport of H2A and H2B histones to thenucleus 0.000120.00167 S000004362ARC18YLR370CverifiedSubunit of the ARP2/3 complex, which is required for themotility and integrity of cortical actinpatches 0.000120.00167 S000005372HTZ1YOL012CverifiedHistone variant H2AZ, exchanged for histone H2A in nucleosomesby the SWR1 complex; involved intranscriptional regulation through preventionof the spread of silent heterochromatin 0.000120.00167 S000001790NUP133YKR082WverifiedSubunit of the Nup84p subcomplex of the nuclear pore complex(NPC), localizes to both sides of the NPC,required to establish a normalnucleocytoplasmic concentration gradient of theGTPase Gsp1p 0.000120.00167 S000003660LSM1YJL124CverifiedLsm (Like Sm) protein; forms heteroheptameric complex (withLsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p)involved in degradation of cytoplasmic mRNAs 0.000120.00167 S000003062PAN2YGL094CverifiedEssential subunit of the Pan2p-Pan3p poly(A)-ribonucleasecomplex, which acts to control poly(A) taillength and regulate the stoichiometry andactivity of postreplication repair complexes 0.000120.00166 S000004045SPT8YLR055CverifiedSubunit of the SAGA transcriptional regulatory complex but notpresent in SAGA-like complex SLIK/SALSA,required for SAGA-mediated inhibition at somepromoters 0.000120.00166 S000003063VPS45YGL095CverifiedProtein of the Sec1p/Munc-18 family, essential for vacuolarprotein sorting; required for the function ofPep12p and the early endosome/late Golgi SNARETlg2p; essential for fusion of Golgi-derivedvesicles with the prevacuolar compartment 0.000120.00166 S000004252YPT6YLR262CverifiedGTPase, Ras-like GTP binding protein involved in the secretorypathway, required for fusion ofendosome-derived vesicles with the late Golgi,maturation of the vacuolar carboxypeptidase Y;has similarity to the human GTPase, Rab6 0.000120.00166 S000002789YRA1YDR381WverifiedNuclear protein that binds to RNA and to Mex67p, required forexport of poly(A)+ mRNA from the nucleus;member of the REF (RNA and export factorbinding proteins) family; another familymember, Yra2p, can substitute for Yra1pfunction 0.000120.00166 S000006005BRO1YPL084WverifiedCytoplasmic class E vacuolar protein sorting (VPS) factor thatcoordinates deubiquitination in themultivesicular body (MVB) pathway by recruitingDoa4p to endosomes 0.000120.00166 S000000455MRPS5YBR251WverifiedMitochondrial ribosomal protein of the small subunit 0.000120.00166 S000004984BDP1YNL039WverifiedEssential subunit of RNA polymerase III transcription factor(TFIIIB), which is involved in transcription ofgenes encoding tRNAs, 5S rRNA, U6 snRNA, andother small RNAs 0.000110.00165 S000005356YNR073CUncharacterizedHypothetical protein 0.000110.00165 S000001123LRP1YHR081WverifiedSubstrate-specific nuclear cofactor for exosome activity in theprocessing of stable RNAs; required fortelomere length maintenance; homolog ofmammalian nuclear matrix protein C1D involvedin regulation of DNA repair and recombination 0.000110.00164 S000004682VPS20YMR077CverifiedMyristoylated subunit of ESCRTIII, the endosomal sortingcomplex required for transport of transmembraneproteins into the multivesicular body pathwayto the lysosomal/vacuolar lumen; cytoplasmicprotein recruited to endosomal membranes 0.000110.00163 S000004597MSC1YML128CverifiedProtein of unknown function; mutant is defective in directingmeiotic recombination events to homologouschromatids; the authentic, non-tagged proteinis detected in highly purified mitochondria inhigh-throughput studies 0.000110.00163 S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.000110.00163 S000005194RAD50YNL250WverifiedSubunit of MRX complex, with Mre11p and Xrs2p, involved inprocessing double-strand DNA breaks invegetative cells, initiation of meiotic DSBs,telomere maintenance, and nonhomologous endjoining 0.000110.00163 S000000602RVS161YCR009CverifiedAmphiphysin-like lipid raft protein; subunit of a complex(Rvs161p-Rvs167p) that regulates polarizationof the actin cytoskeleton, endocytosis, cellpolarity, cell fusion and viability followingstarvation or osmotic stress 0.000110.00163 S000006395QCR2YPR191WverifiedSubunit 2 of the ubiquinol cytochrome-c reductase complex,which is a component of the mitochondrial innermembrane electron transport chain;transcription is regulated by Hap1p,Hap2p/Hap3p, and heme 0.000110.00163 S000003088PRP43YGL120CverifiedRNA helicase in the DEAH-box family, functions in both RNApolymerase I and polymerase II transcriptmetabolism, involved in release of thelariat-intron from the spliceosome 0.000110.00159 S000000039CDC24YAL041WverifiedGuanine nucleotide exchange factor (GEF or GDP-release factor)for Cdc42p; required for polarity establishmentand maintenance, and mutants have morphologicaldefects in bud formation and shmooing 0.000110.00159 S000002430SES1YDR023WverifiedCytosolic seryl-tRNA synthetase, class II aminoacyl-tRNAsynthetase that aminoacylates tRNA(Ser),displays tRNA-dependent amino acid recognitionwhich enhances discrimination of the serinesubstrate, interacts with peroxin Pex21p 0.000110.00159 S000001238NVJ1YHR195WverifiedNuclear envelope protein that interacts with the vacuolarmembrane protein Vac8p to promote formation ofnucleus-vacuole junctions during piecemealmicroautophagy of the nucleus (PMN) 0.000110.00159 S000005133SRP1YNL189WverifiedKaryopherin alpha homolog, forms a dimer with karyopherin betaKap95p to mediate import of nuclear proteins,binds the nuclear localization signal of thesubstrate during import; may also play a rolein regulation of protein degradation 0.000110.00157 S000004842RRP5YMR229CverifiedProtein required for the synthesis of both 18S and 5.8S rRNA;C-terminal region is crucial for the formationof 18S rRNA and N-terminal region is requiredfor the 5.8S rRNA; component of small ribosomalsubunit (SSU) processosome 0.000110.00157 S000004424IMD3YLR432WverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 0.000110.00157 S000004918ADH2YMR303CverifiedGlucose-repressible alcohol dehydrogenase II, catalyzes theconversion of ethanol to acetaldehyde; involvedin the production of certain carboxylateesters; regulated by ADR1 0.000110.00157 S000004925PSE1YMR308CverifiedKaryopherin/importin that interacts with the nuclear porecomplex; acts as the nuclear import receptorfor specific proteins, including Pdr1p, Yap1p,Ste12p, and Aft1p 0.000110.00157 S000001073RRM3YHR031CverifiedDNA helicase involved in rDNA replication and Ty1transposition; relieves replication fork pausesat telomeric regions; structurally andfunctionally related to Pif1p 0.00010.00154 S000002847LRS4YDR439WverifiedProtein involved in rDNA silencing; positively chargedcoiled-coil protein with limited similarity tomyosin 0.00010.00154 S000006082BEM4YPL161CverifiedProtein involved in establishment of cell polarity and budemergence; interacts with the Rho1p smallGTP-binding protein and with the Rho-typeGTPase Cdc42p; involved in maintenance ofproper telomere length 0.00010.00154 S000002718SUM1YDR310CverifiedTranscriptional repressor required for mitotic repression ofmiddle sporulation-specific genes; involved intelomere maintenance, regulated by thepachytene checkpoint 0.00010.00154 S000001234CTF8YHR191CverifiedSubunit of a complex with Ctf18p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion 0.00010.00152 S000000514STP22YCL008CverifiedComponent of the ESCRT-I complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; homologous to the mouse and humanTsg101 tumor susceptibility gene; mutantsexhibit a Class E Vps phenotype 0.00010.00152 S000004476TRM9YML014WverifiedtRNA methyltransferase, catalyzes the esterification ofmodified uridine nucleotides in tRNAs, creating5-methylcarbonylmethyluridine in tRNA(Arg3) and5-methylcarbonylmethyl-2-thiouridine intRNA(Glu); may have a role in stress response 0.00010.00152 S000002905ITR1YDR497CverifiedMyo-inositol transporter with strong similarity to the minormyo-inositol transporter Itr2p, member of thesugar transporter superfamily; expression isrepressed by inositol and choline via Opi1p andderepressed via Ino2p and Ino4p 0.00010.00152&radic S000004494RAD52YML032CverifiedProtein that stimulates strand exchange by facilitating Rad51pbinding to single-stranded DNA; annealscomplementary single-stranded DNA; involved inthe repair of double-strand breaks in DNAduring vegetative growth and meiosis 0.00010.00152 S000003746PEX2YJL210WverifiedRING-finger peroxin, peroxisomal membrane protein with aC-terminal zinc-binding RING domain, formsputative translocation subcomplex with Pex10pand Pex12p which functions in peroxisomalmatrix protein import 0.00010.00152 S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling 0.00010.00152 S000002767VID21YDR359CverifiedComponent of the NuA4 histone acetyltransferase complex 0.00010.00152 S000002544RGP1YDR137WverifiedSubunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) thatcatalyzes nucleotide exchange on Ypt6p 0.00010.0015 S000003719MNN11YJL183WverifiedSubunit of a Golgi mannosyltransferase complex that alsocontains Anp1p, Mnn9p, Mnn10p, and Hoc1p, andmediates elongation of the polysaccharidemannan backbone; has homology to Mnn10p 0.00010.0015 S000003121PEX14YGL153WverifiedPeroxisomal membrane protein that is a central component of theperoxisomal protein import machinery, interactswith PTS1 (Pex5p) and PTS2 (Pex7p) peroxisomalmatrix protein signal recognition factors andmembrane receptor Pex13p 9e-050.00148 S000004138PEP3YLR148WverifiedVacuolar peripheral membrane protein that promotes vesiculardocking/fusion reactions in conjunction withSNARE proteins, required for vacuolarbiogenesis, forms complex with Pep5p thatmediates protein transport to the vacuole 9e-050.00148 S000000818BIM1YER016WverifiedMicrotubule-binding protein that together with Kar9p makes upthe cortical microtubule capture site anddelays the exit from mitosis when the spindleis oriented abnormally 9e-050.00148 S000004844PEP5YMR231WverifiedPeripheral vacuolar membrane protein required for proteintrafficking and vacuole biogenesis; formscomplex with Pep3p that promotes vesiculardocking/fusion reactions in conjunction withSNARE proteins, also interacts with Pep7p 9e-050.00148 S000002408NTH1YDR001CverifiedNeutral trehalase, degrades trehalose; required forthermotolerance and may mediate resistance toother cellular stresses; may be phosphorylatedby Cdc28p 4e-050.00114 S000003506TAF1YGR274CverifiedTFIID subunit (145 kDa), involved in RNA polymerase IItranscription initiation, has histoneacetyltransferase activity, involved inpromoter binding and G1/S progression 4e-050.00113 S000001948RPN12YFR052WverifiedSubunit of the 19S regulatory particle of the 26S proteasomelid; synthetically lethal with RPT1, which isan ATPase component of the 19S regulatoryparticle; physically interacts with Nob1p andRpn3p 4e-050.00111 S000000333OPY1YBR129CverifiedProtein of unknown function, overproduction blocks cell cyclearrest in the presence of mating pheromone; theauthentic, non-tagged protein is detected inhighly purified mitochondria in high-throughputstudies 4e-050.00111 S000004238RCK2YLR248WverifiedProtein kinase involved in the response to oxidative andosmotic stress; identified as suppressor of S.pombe cell cycle checkpoint mutations 4e-050.00111 S000000664ATG15YCR068WverifiedLipase, required for intravacuolar lysis of autophagic bodies;located in the endoplasmic reticulum membraneand targeted to intravacuolar vesicles duringautophagy via the multivesicular body (MVB)pathway 4e-050.00111 S000006383HDA3YPR179CverifiedSubunit of a possibly tetrameric trichostatin A-sensitive classII histone deacetylase complex that contains anHda1p homodimer and an Hda2p-Hda3p heterodimer;required for the activity of the complex; hassimilarity to Hda2p 4e-050.00111 S000004848RNA1YMR235CverifiedGTPase activating protein (GAP) for Gsp1p, involved in nucleartransport 4e-050.00111 S000000639YCR043CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene 4e-050.00111 S000004873TIF11YMR260CverifiedTranslation initiation factor eIF1A, essential protein thatforms a complex with Sui1p (eIF1) and the 40Sribosomal subunit and scans for the startcodon; C-terminus associates with Fun12p(eIF5B); N terminus interacts with eIF2 andeIF3 4e-050.00111 S000002517FOB1YDR110WverifiedNucleolar protein required for DNA replication fork blockingand recombinational hotspot activities; bindsto the replication fork barrier site in therDNA region; related to retroviral integrases 4e-050.00111 S000001031YHL039WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 4e-050.00111 S000000235RPL4AYBR031WverifiedN-terminally acetylated protein component of the large (60S)ribosomal subunit, nearly identical to Rpl4Bpand has similarity to E. coli L4 and rat L4ribosomal proteins 4e-050.00111 S000001675ACP1YKL192CverifiedMitochondrial matrix acyl carrier protein, involved inbiosynthesis of octanoate, which is a precursorto lipoic acid; activated byphosphopantetheinylation catalyzed by Ppt2p 4e-050.00111 S000005254ZIM17YNL310CverifiedHeat shock protein with a zinc finger motif; essential forprotein import into mitochondria; may act withPam18p to facilitate recognition and folding ofimported proteins by Ssc1p (mtHSP70) in themitochondrial matrix 4e-050.00111 S000001729ALY1YKR021WuncharacterizedPutative protein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to the cytoplasm 4e-050.00111 S000002637IVY1YDR229WverifiedPhospholipid-binding protein that interacts with both Ypt7p andVps33p, may partially counteract the action ofVps33p and vice versa, localizes to the rim ofthe vacuole as cells approach stationary phase 4e-050.00111 S000004375SMC6YLR383WverifiedProtein involved in structural maintenance of chromosomes;essential subunit of Mms21-Smc5-Smc6 complex;required for growth, DNA repair,interchromosomal and sister chromatidrecombination; homologous to S. pombe rad18 4e-050.00111 S000000459YBR255WUncharacterizedProtein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 4e-050.00111 S000006069PPT2YPL148CverifiedPhosphopantetheine:protein transferase (PPTase), activatesmitochondrial acyl carrier protein (Acp1p) byphosphopantetheinylation 4e-050.00111 S000006363KRE6YPR159WverifiedProtein required for beta-1,6 glucan biosynthesis; putativebeta-glucan synthase; appears functionallyredundant with Skn1p 4e-050.00111 S000002740IRC3YDR332WuncharacterizedHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 4e-050.00111 S000005702HEM15YOR176WverifiedFerrochelatase, a mitochondrial inner membrane protein,catalyzes the insertion of ferrous iron intoprotoporphyrin IX, the eighth and final step inthe heme biosynthetic pathway 4e-050.00111 S000006277LTP1YPR073CverifiedProtein phosphotyrosine phosphatase of unknown cellular role;activated by adenine 4e-050.00111 S000000110RRN6YBL014CverifiedProtein involved in the transcription of 35S rRNA genes by RNApolymerase I; component of the core factor (CF)complex also composed of Rrn11p, Rrn7p andTATA-binding protein 4e-050.00111 S000000273TAT1YBR069CverifiedAmino acid transport protein for valine, leucine, isoleucine,and tyrosine, low-affinity tryptophan andhistidine transporter; overexpression confersFK506 resistance 4e-050.00111 S000004866YMR253CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene 4e-050.00111 S000004862GAD1YMR250WverifiedGlutamate decarboxylase, converts glutamate intogamma-aminobutyric acid (GABA) during glutamatecatabolism; involved in response to oxidativestress 4e-050.00111 S000001678MIA40YKL195WverifiedEssential protein of the mitochondrial intermembrane space(IMS); promotes retention of newly importedproteins; may do so by stabilizing clientprotein folding as part of a disulfide relaysystem or transferring metal to client proteins 4e-050.00111 S000000575YCL073CUncharacterizedProtein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YKR106W 4e-050.00111 S000002696NSE3YDR288WuncharacterizedEssential subunit of the Mms21-Smc5-Smc6 complex; protein ofunknown function; required for DNA repair andgrowth 4e-050.00111 S000006002RPS9AYPL081WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps9Bp and has similarity to E.coli S4 and rat S9 ribosomal proteins 4e-050.00111 S000006372NUT2YPR168WverifiedComponent of the RNA polymerase II mediator complex, which isrequired for transcriptional activation andalso has a role in basal transcription 4e-050.00111 S000000007SPO7YAL009WverifiedIntegral nuclear/ER membrane protein of unknown function,required for normal nuclear envelope morphologyand sporulation 4e-050.00111 S000000523LEU2YCL018WverifiedBeta-isopropylmalate dehydrogenase, catalyzes the third step inthe leucine biosynthesis pathway 4e-050.00111 S000004212UTP13YLR222CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 4e-050.00111 S000003154TPN1YGL186CverifiedPlasma membrane pyridoxine (vitamin B6) transporter; member ofthe purine-cytosine permease subfamily withinthe major facilitator superfamily; protonsymporter with similarity to Fcy21p, Fcy2p, andFcy22p 4e-050.00111 S000004651CSM3YMR048WverifiedProtein required for accurate chromosome segregation duringmeiosis 4e-050.00111 S000005764YOR238WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 4e-050.00111 S000000677SRB8YCR081WverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation; involved in glucoserepression 4e-050.00111 S000005796VPH1YOR270CverifiedSubunit of vacuolar-ATPase V0 domain, one of two isoforms(Vph1p and Stv1p); Vph1p is located in V-ATPasecomplexes of the vacuole while Stv1p is locatedin V-ATPase complexes of the Golgi andendosomes 4e-050.00111 S000000829GAL83YER027CverifiedOne of three possible beta-subunits of the Snf1 kinase complex,allows nuclear localization of the Snf1 kinasecomplex in the presence of a nonfermentablecarbon source; contains glycogen-binding domain 4e-050.00111 S000000799YEL073CUncharacterizedPutative protein of unknown function; located adjacent to ARS503 and the telomere on the left arm of chromosome V; regulated by inositol/choline 4e-050.00111 S000001304PKP1YIL042CverifiedMitochondrial kinase, phosphorylates pyruvate dehydrogenasealpha subunit Pda1p 4e-050.00111 S000001391TAO3YIL129CverifiedProtein involved in cell morphogenesis and proliferation,associated with protein kinase Cbk1p; mutantsactivate OCH1 transcription 4e-050.00111 S000028423ERI1YPL096C-AverifiedEndoplasmic reticulum membrane protein that binds to andinhibits GTP-bound Ras2p at the ER; componentof the GPI-GnT complex which catalyzes thefirst step in GPI-anchor biosynthesis; probablehomolog of mammalian PIG-Y protein 4e-050.00111 S000003978YLL055WUncharacterizedPutative protein of unknown function with similarity to transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLL055W is not an essential gene 4e-050.00111 S000002999RPL24AYGL031CverifiedRibosomal protein L30 of the large (60S) ribosomal subunit,nearly identical to Rpl24Bp and has similarityto rat L24 ribosomal protein; not essential fortranslation but may be required for normaltranslation rate 4e-050.00111 S000001602VPH2YKL119CverifiedIntegral membrane protein required for vacuolar H+-ATPase(V-ATPase) function, although not an actualcomponent of the V-ATPase complex; functions inthe assembly of the V-ATPase; localized to theendoplasmic reticulum (ER) 4e-050.00111 S000004364SUR4YLR372WverifiedElongase, involved in fatty acid and sphingolipid biosynthesis;synthesizes very long chain 20-26-carbon fattyacids from C18-CoA primers; involved inregulation of sphingolipid biosynthesis 4e-050.00111 S000000691OCA4YCR095CuncharacterizedCytoplasmic protein required for replication of Brome mosaicvirus in S. cerevisiae, which is a model systemfor studying replication of positive-strand RNAviruses in their natural hosts 4e-050.00111 S000003826ARP3YJR065CverifiedEssential component of the Arp2/3 complex, which is a highlyconserved actin nucleation center required forthe motility and integrity of actin patches;involved in endocytosis and membrane growth andpolarity 4e-050.00111 S000000325GRS1YBR121CverifiedCytoplasmic and mitochondrial glycyl-tRNA synthase that ligatesglycine to the cognate anticodon bearing tRNA;transcription termination factor that mayinteract with the 3'-end of pre-mRNA to promote3'-end formation 4e-050.00111 S000004560RAD10YML095CverifiedSingle-stranded DNA endonuclease (with Rad1p), cleavessingle-stranded DNA during nucleotide excisionrepair and double-strand break repair; subunitof Nucleotide Excision Repair Factor 1 (NEF1);homolog of human ERCC1 protein 4e-050.00111 S000003679TIM17YJL143WverifiedEssential constituent of the mitochondrial inner membranepresequence translocase; interacts with Pam18pto recruit the presequencetranslocase-associated motor (PAM complex) andalso required for protein sorting during import 4e-050.00111 S000001370YIL108WUncharacterizedPutative metalloprotease 4e-050.00111 S000006378YPR174CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate 4e-050.00111 S000005962YPL041CUncharacterizedProtein of unknown function involved in maintenance of proper telomere length 4e-050.00111 S000003141KEM1YGL173CverifiedEvolutionarily-conserved 5'-3' exonuclease component ofcytoplasmic processing (P) bodies involved inmRNA decay; plays a role inmicrotubule-mediated processes, filamentousgrowth, ribosomal RNA maturation, and telomeremaintenance 4e-050.00111 S000028683YLR406C-AUncharacterizedPutative protein of unknown function 4e-050.00111 S000001803MLP1YKR095WverifiedMyosin-like protein associated with the nuclear envelope,connects the nuclear pore complex with thenuclear interior; involved with Tel1p intelomere length control; involved with Pml1pand Pml39p in nuclear retention of unsplicedmRNAs 4e-050.00111 S000002416GAL3YDR009WverifiedTranscriptional regulator involved in activation of the GALgenes in response to galactose; forms a complexwith Gal80p to relieve Gal80p inhibition ofGal4p; binds galactose and ATP but does nothave galactokinase activity 4e-050.00111 S000000205NTH2YBR001CverifiedPutative neutral trehalase, required for thermotolerance andmay mediate resistance to other cellularstresses 4e-050.00111 S000002263NSE4YDL105WverifiedNuclear protein that plays a role in the function of theSmc5p-Rhc18p complex 4e-050.00111 S000004157RPS31YLR167WverifiedFusion protein that is cleaved to yield a ribosomal protein ofthe small (40S) subunit and ubiquitin;ubiquitin may facilitate assembly of theribosomal protein into ribosomes; interactsgenetically with translation factor eIF2B 4e-050.00111 S000001028MUP3YHL036WverifiedLow affinity methionine permease, similar to Mup1p 4e-050.00111 S000001278SNL1YIL016WverifiedProtein of unknown function proposed to be involved in nuclearpore complex biogenesis and maintenance as wellas protein folding; has similarity to themammalian BAG-1 protein 4e-050.00111 S000000993RPL14BYHL001WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl14Ap and has similarity to ratL14 ribosomal protein 4e-050.00111 S000005011RPL9BYNL067WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl9Ap and has similarity to E.coli L6 and rat L9 ribosomal proteins 4e-050.00111 S000005175PDR16YNL231CverifiedPhosphatidylinositol transfer protein (PITP) controlled by themultiple drug resistance regulator Pdr1p,localizes to lipid particles and microsomes,controls levels of various lipids, may regulatelipid synthesis, homologous to Pdr17p 4e-050.00111&radic S000005957PMA2YPL036WverifiedPlasma membrane H+-ATPase, isoform of Pma1p, involved inpumping protons out of the cell; regulator ofcytoplasmic pH and plasma membrane potential 4e-050.00111 S000005972ARL3YPL051WverifiedGTPase of the Ras superfamily required to recruit Arl1p to theGolgi; similar to ADP-ribosylation factor 4e-050.00111 S000002480SNF11YDR073WverifiedSubunit of the SWI/SNF chromatin remodeling complex involved intranscriptional regulation; interacts with ahighly conserved 40-residue sequence of Snf2p 4e-050.00111 S000001947RET2YFR051CverifiedDelta subunit of the coatomer complex (COPI), which coatsGolgi-derived transport vesicles; involved inretrograde transport between Golgi and ER 4e-050.00111 S000005248YPT11YNL304WverifiedRab-type small GTPase that interacts with the C-terminal taildomain of Myo2p to mediate distribution ofmitochondria to daughter cells 4e-050.00111 S000000633PHO87YCR037CverifiedLow-affinity inorganic phosphate (Pi) transporter, involved inactivation of PHO pathway; expression isindependent of Pi concentration and Pho4pactivity; contains 12 membrane-spanningsegments 4e-050.00111 S000000138FUI1YBL042CverifiedHigh affinity uridine permease, localized to the plasmamembrane; not involved in uracil transport 4e-050.00111&radic S000000184TEL1YBL088CverifiedProtein kinase primarily involved in telomere lengthregulation; contributes to cell cyclecheckpoint control in response to DNA damage;functionally redundant with Mec1p; homolog ofhuman ataxia telangiectasia (ATM) gene 4e-050.00111 S000001441MPH1YIR002CverifiedMember of the DEAH family of helicases, functions in anerror-free DNA damage bypass pathway thatinvolves homologous recombination, mutationsconfer a mutator phenotype 4e-050.00111 S000003465PHO81YGR233CverifiedCyclin-dependent kinase (CDK) inhibitor, regulatesPho80p-Pho85p and Pcl7p-Pho85p cyclin-CDKcomplexes in response to phosphate levels;required for derepression of PHO5;transcriptionally regulated by Pho4p and Pho2p 4e-050.00111 S000000135URA7YBL039CverifiedMajor CTP synthase isozyme (see also URA8), catalyzes theATP-dependent transfer of the amide nitrogenfrom glutamine to UTP, forming CTP, the finalstep in de novo biosynthesis of pyrimidines;involved in phospholipid biosynthesis 4e-050.00111 S000003715PFD1YJL179WverifiedSubunit of heterohexameric prefoldin, which binds cytosolicchaperonin and transfers target proteins to it;involved in the biogenesis of actin and ofalpha- and gamma-tubulin 4e-050.00111 S000004861RKR1YMR247CverifiedProtein of unknown function; may interact with ribosomes, basedon co-purification experiments; YMR247C is notan essential gene 4e-050.00111 S000004748SIP5YMR140WverifiedProtein of unknown function; interacts with both theReg1p/Glc7p phosphatase and the Snf1p kinase 4e-050.00111 S000003169MCM6YGL201CverifiedProtein involved in DNA replication; component of the Mcm2-7hexameric complex that binds chromatin as apart of the pre-replicative complex 4e-050.00111 S000028536YCR108CUncharacterizedPutative protein of unknown function; identified by fungal homology and RT-PCR 4e-050.00111 S000001907YFR011CUncharacterizedPutative protein of unknown function; localizes to the mitochondrion; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR011C is not an essential gene 4e-050.00111 S000001400TPM2YIL138CverifiedMinor isoform of tropomyosin, binds to and stabilizes actincables and filaments, which direct polarizedcell growth and the distribution of severalorganelles; appears to have distinct and alsooverlapping functions with Tpm1p 4e-050.00111 S000000126PET9YBL030CverifiedMajor ADP/ATP carrier of the mitochondrial inner membrane,exchanges cytosolic ADP for mitochondriallysynthesized ATP; required for viability in manycommon lab strains carrying a mutation in thepolymorphic SAL1 gene 4e-050.00111 S000005218YNL274CUncharacterizedPutative hydroxyisocaproate dehydrogenase 4e-050.00111 S000005183LAP3YNL239WverifiedAminopeptidase of cysteine protease family, has a DNA bindingactivity and acts as bleomycin hydrolase invitro; transcription is regulated by galactosevia Gal4p 4e-050.00111 S000005640YOR114WUncharacterizedHypothetical protein 4e-050.00111 S000001070DAP2YHR028CverifiedDipeptidyl aminopeptidase, synthesized as a glycosylatedprecursor; localizes to the vacuolar membrane;similar to Ste13p 4e-050.00111 S000000097ECM15YBL001CverifiedNon-essential protein of unknown function, likely exists astetramer, may be regulated by the binding ofsmall-molecule ligands (possibly sulfate ions),may have a role in yeast cell-wall biogenesis 4e-050.00111 S000004111YPS3YLR121CverifiedAspartic protease, attached to the plasma membrane via aglycosylphosphatidylinositol (GPI) anchor 4e-050.00111 S000004042IES3YLR052WverifiedSubunit of the INO80 chromatin remodeling complex 4e-050.00111 S000002639COX20YDR231CverifiedMitochondrial inner membrane protein, required for proteolyticprocessing of Cox2p and its assembly intocytochrome c oxidase 4e-050.00111 S000005611OST3YOR085WverifiedGamma subunit of the oligosaccharyltransferase complex of theER lumen, which catalyzes asparagine-linkedglycosylation of newly synthesized proteins;Ost3p is important for N-glycosylation of asubset of proteins 4e-050.00111 S000002720SSF2YDR312WverifiedProtein required for ribosomal large subunit maturation,functionally redundant with Ssf1p; member ofthe Brix family 4e-050.00111 S000004752YMR144WUncharacterizedPutative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene 4e-050.00111 S000005001OCA2YNL056WuncharacterizedPutative protein with similarity to predicted tyrosinephosphatases Oca1p and Siw14p; greenfluorescent protein (GFP)-fusion proteinlocalizes to the cytoplasm; YNL056W is not anessential gene 4e-050.00111 S000004257BOP2YLR267WuncharacterizedProtein of unknown function, overproduction suppresses a pam1slv3 double null mutation 4e-050.00111 S000000894IES5YER092WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 4e-050.00111 S000005376CMK2YOL016CverifiedCalmodulin-dependent protein kinase; may play a role in stressresponse, many CA++/calmodulan dependentphosphorylation substrates demonstrated invitro, amino acid sequence similar to Cmk1p andmammalian Cam Kinase II 4e-050.00111 S000003665TRK1YJL129CverifiedComponent of the Trk1p-Trk2p potassium transport system; 180kDa high affinity potassium transporter;phosphorylated in vivo and interacts physicallywith the phosphatase Ppz1p, suggesting Trk1pacitivy is regulated by phosphorylation 4e-050.00111 S000003782REC107YJR021CverifiedProtein involved in early stages of meiotic recombination;involved in altering chromatin structure at DNAdouble-stranded break sites and in coordinationbetween the initiation of recombination and thefirst division of meiosis 4e-050.00111 S000003986AYT1YLL063CverifiedAcetyltransferase; catalyzes trichothecene 3-O-acetylation,suggesting a possible role in trichothecenebiosynthesis 4e-050.00111 S000004462YML003WUncharacterizedHypothetical protein 4e-050.00111 S000028686YLR466C-BUncharacterizedDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data 4e-050.00111 S000001229KOG1YHR186CverifiedSubunit of TORC1, a rapamycin-sensitive complex involved ingrowth control that contains Tor1p or Tor2p,Lst8p and Tco89p; contains four HEAT repeatsand seven WD-40 repeats; may act as a scaffoldprotein to couple TOR and its effectors 4e-050.00111 S000001170FUR1YHR128WverifiedUracil phosphoribosyltransferase, synthesizes UMP from uracil;involved in the pyrimidine salvage pathway 4e-050.00111 S000003499FOL2YGR267CverifiedGTP-cyclohydrolase I, catalyzes the first step in the folicacid biosynthetic pathway 4e-050.00111 S000004725ASI1YMR119WverifiedPutative integral membrane E3 ubiquitin ligase; acts with Asi2pand Asi3p to ensure the fidelity of SPS-sensorsignalling by maintaining the dormant repressedstate of gene expression in the absence ofinducing signals 4e-050.00111 S000000963SPT2YER161CverifiedProtein involved in negative regulation of transcription;required for RNA polyadenylation; exhibitsregulated interactions with both histones andSWI-SNF components, has similarity to mammalianHMG1 proteins 4e-050.00111 S000004546YML081WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YML081w is not an essential gene 4e-050.00111 S000004991YNL046WUncharacterizedPutative protein of unknown function; expression depends on Swi5p; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL046W is not an essential gene 4e-050.00111 S000001179ARO9YHR137WverifiedAromatic aminotransferase, catalyzes the first step oftryptophan, phenylalanine, and tyrosinecatabolism 4e-050.00111 S000000225FUR4YBR021WverifiedUracil permease, localized to the plasma membrane; expressionis tightly regulated by uracil levels andenvironmental cues 4e-050.00111 S000006306RPL11AYPR102CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl11Bp; involved in ribosomalassembly; depletion causes degradation ofproteins and RNA of the 60S subunit; hassimilarity to E. coli L5 and rat L11 4e-050.00111 S000000076YAR028WUncharacterizedPutative integral membrane protein, member of DUP240 gene family 4e-050.00111 S000005126IPI3YNL182CuncharacterizedProtein required for cell viability; computational analysis oflarge-scale protein-protein interaction datasuggests a possible role in assembly of theribosomal large subunit 4e-050.00111 S000004490TSA1YML028WverifiedUbiquitous housekeeping thioredoxin peroxidase, reducesreactive oxygen, nitrogen and sulfur speciesusing thioredoxin as hydrogen donor; mediatesredox regulation of the nuclear localization ofYap1p; deletion results in mutator phenotype 4e-050.00111 S000001377NUP159YIL115CverifiedSubunit of the nuclear pore complex that is found exclusivelyon the cytoplasmic side, forms a subcomplexwith Nup82p and Nsp1p, required for mRNA export 4e-050.00111 S000003529QCR10YHR001W-AverifiedSubunit of the ubiqunol-cytochrome c oxidoreductase complex,involved in aerobic respiration 4e-050.00111 S000004981NCE103YNL036WverifiedCarbonic anhydrase; poorly transcribed under aerobic conditionsand at an undetectable level under anaerobicconditions; involved in non-classical proteinexport pathway 4e-050.00111 S000002736SKP1YDR328CverifiedEvolutionarily conserved kinetochore protein that is part ofmultiple protein complexes, including the SCFubiquitin ligase complex, the CBF3 complex thatbinds centromeric DNA, and the RAVE complexthat regulates assembly of the V-ATPase 4e-050.00111 S000003067LSG1YGL099WverifiedPutative GTPase involved in 60S ribosomal subunit biogenesis;required for the release of Nmd3p from 60Ssubunits in the cytoplasm 4e-050.00111 S000001910CMK1YFR014CverifiedCalmodulin-dependent protein kinase; may play a role in stressresponse, many CA++/calmodulan dependentphosphorylation substrates demonstrated invitro, amino acid sequence similar to Cmk2p andmammalian Cam Kinase II 4e-050.00111 S000001616YKL133CUncharacterizedHypothetical protein 4e-050.00111 S000003716ATP12YJL180CverifiedConserved protein required for assembly of alpha and betasubunits into the F1 sector of mitochondrialF1F0 ATP synthase; mutation of human ATP12reduces active ATP synthase levels and isassociated with the disorder ATPAF2 deficiency 4e-050.00111 S000001268YIA6YIL006WverifiedMitochondrial NAD+ transporter, involved in the transport ofNAD+ into the mitochondria (see also YEA6);member of the mitochondrial carrier subfamily;disputed role as a pyruvate transporter; hasputative mouse and human orthologs 4e-050.00111 S000001220YHR177WUncharacterized 4e-050.00111 S000004860FAA4YMR246WverifiedLong chain fatty acyl-CoA synthetase, regulates proteinmodification during growth in the presence ofethanol, functions to incorporate palmitic acidinto phospholipids and neutral lipids 4e-050.00111 S000001620YKL137WUncharacterizedPutative protein of unknown function; mutation results in growth defect on a non-fermentable (respiratory) carbon source 4e-050.00111 S000002463YDR056CUncharacterizedHypothetical protein 4e-050.00111 S000005718THI72YOR192CuncharacterizedTransporter of thiamine or related compound; shares sequencesimilarity with Thi7p 4e-050.00111 S000000341YBR137WUncharacterizedProtein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); YBR137W is not an essential gene 4e-050.00111 S000005499CDC33YOL139CverifiedCytoplasmic mRNA cap binding protein; the eIF4E-cap complex isresponsible for mediating cap-dependent mRNAtranslation via interactions with thetranslation initiation factor eIF4G (Tif4631por Tif4632p) 4e-050.00111 S000003219YGL250WUncharacterizedPutative protein of unknown function; deletion mutant results in reduced PIS1 expression and has growth defects on non-fermentable carbon sources and on minimal media; GFP-fusion protein localizes to both the cytoplasm and the nucleus 4e-050.00111 S000028852YNL277W-AUncharacterizedPutative protein of unknown function 4e-050.00111 S000000445YBR241CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene 4e-050.00111 S000003808ANB1YJR047CverifiedTranslation initiation factor eIF-5A, promotes formation of thefirst peptide bond; similar to and functionallyredundant with Hyp2p; undergoes an essentialhypusination modification; expressed underanaerobic conditions 4e-050.00111 S000004097REX3YLR107WverifiedRNA exonuclease; required for maturation of the RNA componentof RNase MRP; functions redundantly with Rnh70pand Rex2p in processing of U5 snRNA and RNase PRNA; member of RNase D family of exonucleases 4e-050.00111 S000005245RPL18BYNL301CverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl18Ap and has similarity to ratL18 ribosomal protein 4e-050.00111 S000004236ERF2YLR246WverifiedSubunit of a palmitoyltransferase, composed of Erf2p and Shr5p,that adds a palmitoyl lipid moiety toheterolipidated substrates such as Ras1p andRas2p through a thioester linkage; mutantspartially mislocalize Ras2p to the vacuole 4e-050.00111 S000003590TIM54YJL054WverifiedComponent of the mitochondrial Tim54p-Tim22p complex involvedin insertion of polytopic proteins into theinner membrane 4e-050.00111 S000005026PMS1YNL082WverifiedATP-binding protein required for mismatch repair in mitosis andmeiosis; functions as a heterodimer with Mlh1p,binds double- and single-stranded DNA via itsN-terminal domain, similar to E. coli MutL 4e-050.00111 S000005166SSU72YNL222WverifiedTranscription/RNA-processing factor that associates with TFIIBand cleavage/polyadenylation factor Pta1p;exhibits phosphatase activity on serine-5 ofthe RNA polymerase II C-terminal domain;affects start site selection in vivo 4e-050.00111 S000004630TAP42YMR028WverifiedEssential protein involved in the TOR signaling pathway;physically associates with the proteinphosphatase 2A and the SIT4 protein phosphatasecatalytic subunits 4e-050.00111 S000003741YJL206CUncharacterizedPutative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment 4e-050.00111 S000005205ORC5YNL261WverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing 4e-050.00111 S000000696YCR099CUncharacterizedHypothetical protein 4e-050.00111 S000005182KEX2YNL238WverifiedSubtilisin-like protease (proprotein convertase), acalcium-dependent serine protease involved inthe activation of proproteins of the secretorypathway 4e-050.00111 S000007525YNR034W-AUncharacterizedHypothetical protein 4e-050.00111 S000003677YAK1YJL141CverifiedSerine-threonine protein kinase that is part of aglucose-sensing system involved in growthcontrol in response to glucose availability;translocates from the cytoplasm to the nucleusand phosphorylates Pop2p in response to aglucose signal 4e-050.00111 S000028654YHR214C-EUncharacterizedIdentified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 4e-050.00111 S000003119NUT1YGL151WverifiedComponent of the RNA polymerase II mediator complex, which isrequired for transcriptional activation andalso has a role in basal transcription 4e-050.00111 S000000610CWH43YCR017CverifiedPutative sensor/transporter protein involved in cell wallbiogenesis; contains 14-16 transmembranesegments and several putative glycosylation andphosphorylation sites; null mutation issynthetically lethal with pkc1 deletion 4e-050.00111 S000001534SFK1YKL051WverifiedPlasma membrane protein that may act together with or upstreamof Stt4p to generate normal levels of theessential phospholipid PI4P, at least partiallymediates proper localization of Stt4p to theplasma membrane 4e-050.00111 S000003265TIM21YGR033CverifiedConstituent of the mitochondrial inner membrane presequencetranslocase (TIM23 complex); may regulateprotein import by binding to both thetranslocase of the outer membrane (TOM) andpresequence-associated motor (PAM) complexes 4e-050.00111 S000005889PRE10YOR362Cverified20S proteasome alpha-type subunit 4e-050.00111 S000006371MET16YPR167Cverified3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylylsulfate to adenosine-3',5'-bisphosphate andfree sulfite using reduced thioredoxin ascosubstrate, involved in sulfate assimilationand methionine metabolism 4e-050.00111 S000005316ABZ1YNR033WverifiedPara-aminobenzoate (PABA) synthase, has similarity toEscherichia coli PABA synthase components PabAand PabB 4e-050.00111 S000028827YGR035W-AUncharacterizedPutative protein of unknown function 4e-050.00111 S000003969RNP1YLL046CverifiedRibonucleoprotein that contains two RNA recognition motifs(RRM) 4e-050.00111 S000006249MNI2YPR045CuncharacterizedDeletion mutant is synthetically lethal with MEN mutants 4e-050.00111 S000007260COX1Q0045verifiedSubunit I of cytochrome c oxidase, which is the terminal memberof the mitochondrial inner membrane electrontransport chain; one of threemitochondrially-encoded subunits 4e-050.00111 S000004154YLR164WUncharacterizedPutative protein of unknown function that localizes to the mitochondrial inner membrane; similar to Tim18p and to Sdh4p 4e-050.00111 S000006147NEW1YPL226WverifiedATP binding cassette family member; Asn/Gln-rich rich regionsupports [NU+] prion formation, susceptibilityto [PSI+] prion induction and aggregation of afragment of the human Machado-Joseph Diseaseprotein 4e-050.00111 S000003403MSM1YGR171CverifiedMitochondrial methionyl-tRNA synthetase (MetRS), functions as amonomer in mitochondrial protein synthesis;functions similarly to cytoplasmic MetRSalthough the cytoplasmic form contains azinc-binding domain not found in Msm1p 4e-050.00111 S000005298SMM1YNR015WverifiedDihydrouridine synthase, member of a family of dihydrouridinesynthases including Dus1p, Smm1p, Dus3p, andDus4p; modifies uridine residues at position 20of cytoplasmic tRNAs 4e-050.00111 S000028810YNL067W-BUncharacterizedPutative protein of unknown function 4e-050.00111 S000003129YIP5YGL161CverifiedProtein that interacts with Rab GTPases; computational analysisof large-scale protein-protein interaction datasuggests a possible role in vesicle-mediatedtransport 4e-050.00111 S000005237MSB3YNL293WverifiedGTPase-activating protein for Sec4p and several other RabGTPases, regulates exocytosis via its action onSec4p, also required for proper actinorganization; similar to Msb4p; both Msb3p andMsb4p localize to sites of polarized growth 4e-050.00111 S000000979BMH1YER177Wverified14-3-3 protein, major isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others 4e-050.00111 S000001121IRE1YHR079CverifiedSerine-threonine kinase and endoribonuclease; transmembraneprotein that initiates the unfolded proteinresponse signal by regulating synthesis ofHac1p through HAC1 mRNA splicing 4e-050.00111 S000004412URA4YLR420WverifiedDihydroorotase, catalyzes the third enzymatic step in the denovo biosynthesis of pyrimidines, convertingcarbamoyl-L-aspartate into dihydroorotate 4e-050.00111 S000028512PCC1YKR095W-AverifiedProposed transcription factor involved in the expression ofgenes regulated by alpha-factor and galactose;component of the EKC/KEOPS protein complex withKae1p, Gon7p, Bud32p, and Cgi121p; related tohuman cancer-testis antigens 4e-050.00111 S000002459DBF4YDR052CverifiedRegulatory subunit of Cdc7p-Dbf4p kinase complex, required forCdc7p kinase activity and initiation of DNAreplication; phosphorylates the Mcm2-7 familyof proteins; cell cycle regulated 4e-050.00111 S000001269NAS2YIL007CverifiedProtein with similarity to the p27 subunit of mammalianproteasome modulator; not essential; interactswith Rpn4p 4e-050.00111 S000005093PGA2YNL149CuncharacterizedEssential protein required for maturation of Gas1p and Pho8p;involved in protein trafficking; GFP-fusionprotein localizes to the ER and YFP-fusionprotein to the nuclear envelope-ER network;null mutants have a cell separation defect 4e-050.00111 S000001087YHR045WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum 4e-050.00111 S000006355SUE1YPR151CverifiedMitochondrial protein required for degradation of unstableforms of cytochrome c 4e-050.00111 S000004737YMR130WUncharacterizedHypothetical protein 4e-050.00111 S000003648MDV1YJL112WverifiedPeripheral protein of the cytosolic face of the mitochondrialouter membrane, required for mitochondrialfission; interacts with Fis1p and with thedynamin-related GTPase Dnm1p; contains WDrepeats 4e-050.00111 S000006020FMP14YPL099CuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 4e-050.00111 S000001115OSH3YHR073WverifiedMember of an oxysterol-binding protein family with sevenmembers in S. cerevisiae; family members haveoverlapping, redundant functions in sterolmetabolism and collectively perform a functionessential for viability 4e-050.00111 S000005070SPC98YNL126WverifiedComponent of the microtubule-nucleating Tub4p (gamma-tubulin)complex; interacts with Spc110p at the spindlepole body (SPB) inner plaque and with Spc72p atthe SPB outer plaque 4e-050.00111 S000005096YNL152WUncharacterizedProtein required for cell viability 4e-050.00111 S000001359FYV10YIL097WverifiedProtein of unknown function, required for survival uponexposure to K1 killer toxin; involved inproteasome-dependent catabolite inactivation offructose-1,6-bisphosphatase; contains CTLHdomain 4e-050.00111 S000005585YOR059CUncharacterizedHypothetical protein 4e-050.00111 S000005591CYT1YOR065WverifiedCytochrome c1, component of the mitochondrial respiratorychain; expression is regulated by theheme-activated, glucose-repressedHap2p/3p/4p/5p CCAAT-binding complex 4e-050.00111 S000028519YCR075W-AUncharacterizedPutative protein of unknown function; identified by homology to Ashbya gossypii 4e-050.00111 S000004199PNP1YLR209CverifiedPurine nucleoside phosphorylase, specifically metabolizesinosine and guanosine nucleosides 4e-050.00111 S000000062SEO1YAL067CverifiedPutative permease, member of the allantoate transportersubfamily of the major facilitator superfamily;mutation confers resistance to ethioninesulfoxide 4e-050.00111 S000002888DIG2YDR480WverifiedRegulatory protein of unknown function, pheromone-inducible,involved in the regulation of mating-specificgenes and the invasive growth pathway, requiredfor MAP-kinase imposed repression, inhibitspheromone-responsive transcription 4e-050.00111 S000002358YDL199CUncharacterizedPutative protein of unknown function with sequence similarity to members of the sugar permease family 4e-050.00111 S000003825CCT5YJR064WverifiedSubunit of the cytosolic chaperonin Cct ring complex, relatedto Tcp1p, required for the assembly of actinand tubulins in vivo 4e-050.00111 S000003356ASN2YGR124WverifiedAsparagine synthetase, isozyme of Asn1p; catalyzes thesynthesis of L-asparagine from L-aspartate inthe asparagine biosynthetic pathway 4e-050.00111 S000001501SWD2YKL018WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lys 4 and is involved intelomeric silencing; subunit of CPF (cleavageand polyadenylation factor), a complex involvedin RNAP II transcription termination 4e-050.00111 S000003935YEH1YLL012WverifiedSteryl ester hydrolase, one of three gene products (Yeh1p,Yeh2p, Tgl1p) responsible for steryl esterhydrolase activity and involved in sterolhomeostasis; localized to lipid particlemembranes 4e-050.00111 S000000788NPR2YEL062WverifiedProtein with a possible role in regulating expression ofnitrogen permeases; transcription is induced inresponse to proline and urea; contains two PESTsequences; null mutant is resistant tocisplatin and doxorubicin 4e-050.00111 S000006431YOR008C-AUncharacterizeddiepoxybutane and mitomycin C resistance 4e-050.00111 S000000326MRPL36YBR122CverifiedMitochondrial ribosomal protein of the large subunit;overproduction suppresses mutations in the COX2leader peptide-encoding region 4e-050.00111 S000004147ASP3-2YLR157CverifiedCell-wall L-asparaginase II, involved in asparagine catabolism;expression is induced during nitrogenstarvation; four copies of ASP3 are present inthe genome reference strain S288C 4e-050.00111 S000003564YJL027CUncharacterizedHypothetical protein 4e-050.00111 S000001414YIL152WUncharacterizedHypothetical protein 4e-050.00111 S000000947FTR1YER145CverifiedHigh affinity iron permease involved in the transport of ironacross the plasma membrane; forms complex withFet3p; expression is regulated by iron 4e-050.00111 S000003237TFG2YGR005CverifiedTFIIF (Transcription Factor II) middle subunit; involved inboth transcription initiation and elongation ofRNA polymerase II; homologous to human RAP30 4e-050.00111 S000001438PAU14YIL176CuncharacterizedHypothetical protein 4e-050.00111 S000004481OST6YML019WverifiedSubunit of the oligosaccharyltransferase complex of the ERlumen, which catalyzes asparagine-linkedglycosylation of newly synthesized proteins;similar to and partially functionally redundantwith Ost3p 4e-050.00111 S000001107RRP3YHR065CverifiedProtein involved in rRNA processing; required for maturation ofthe 35S primary transcript of pre-rRNA and forcleavage leading to mature 18S rRNA; homologousto eIF-4a, which is a DEAD box RNA-dependentATPase with helicase activity 4e-050.00111 S000004497SRC1YML034WverifiedProtein with a putative role in sister chromatid segregation,potentially phosphorylated by Cdc28p; greenfluorescent protein (GFP)-fusion proteinlocalizes to the nuclear periphery 4e-050.00111 S000000431MCX1YBR227CverifiedMitochondrial ATP-binding protein, possibly a mitochondrialchaperone with non-proteolytic function;similar to bacterial ClpX proteins 4e-050.00111 S000005333LYS9YNR050CverifiedSaccharopine dehydrogenase (NADP+, L-glutamate-forming);catalyzes the formation of saccharopine fromalpha-aminoadipate 6-semialdehyde, which is theseventh step in lysine biosynthesis pathway 4e-050.00111 S000005394SMC5YOL034WverifiedStructural maintenance of chromosomes (SMC) protein; essentialsubunit of the Mms21-Smc5-Smc6 complex;required for growth and DNA repair; S. pombehomolog forms a heterodimer with S. pombeRad18p that is involved in DNA repair 4e-050.00111 S000001830YFL064CUncharacterizedPutative protein of unknown function 4e-050.00111 S000002979SCL1YGL011CverifiedAlpha subunit of the 20S core complex of the 26S proteasomeinvolved in the degradation of ubiquitinatedsubstrates; essential for growth; detected inthe mitochondria 4e-050.00111 S000003005PNC1YGL037CverifiedNicotinamidase that converts nicotinamide to nicotinic acid aspart of the NAD(+) salvage pathway, requiredfor life span extension by calorie restriction;PNC1 expression responds to all known stimulithat extend replicative life span 4e-050.00111 S000006157YPL236CUncharacterizedHypothetical protein 4e-050.00111 S000005985CWC27YPL064CverifiedComponent of a complex containing Cef1p, putatively involved inpre-mRNA splicing; has similarity to S. pombeCwf27p 4e-050.00111 S000005297YNR014WUncharacterizedHypothetical protein 4e-050.00111 S000005355HXT17YNR072WverifiedHexose transporter, up-regulated in media containing raffinoseand galactose at pH 7.7 versus pH 4.7,repressed by high levels of glucose 4e-050.00111 S000003192SDT1YGL224CverifiedPyrimidine nucleotidase; overexpression suppresses the 6-AUsensitivity of transcription elongation factorS-II, as well as resistance to other pyrimidinederivatives 4e-050.00111 S000004951LST8YNL006WverifiedProtein required for the transport of amino acid permease Gap1pfrom the Golgi to the cell surface; componentof the TOR signaling pathway; associates withboth Tor1p and Tor2p; contains a WD-repeat 4e-050.00111 S000000412DUR1,2YBR208CverifiedUrea amidolyase, contains both urea carboxylase and allophanatehydrolase activities, degrades urea to CO2 andNH3; expression sensitive to nitrogencatabolite repression and induced byallophanate, an intermediate in allantoindegradation 4e-050.00111 S000001250SET5YHR207CverifiedZinc-finger protein of unknown function, contains one canonicaland two unusual fingers in unusualarrangements; deletion enhances replication ofpositive-strand RNA virus 4e-050.00111 S000003240STF2YGR008CverifiedProtein involved in regulation of the mitochondrial F1F0-ATPsynthase; Stf1p and Stf2p act as stabilizingfactors that enhance inhibitory action of theInh1p protein 4e-050.00111 S000004146YLR156WUncharacterizedYLR156W, YLR159W, and YLR161W are three identical open reading frames encoded near the ribosomal DNA region of chromosome 12. 4e-050.00111 S000002449YDR042CUncharacterizedHypothetical protein 4e-050.00111 S000001922YFR026CUncharacterizedHypothetical protein 4e-050.00111 S000003563RNR2YJL026WverifiedRibonucleotide-diphosphate reductase (RNR), small subunit; theRNR complex catalyzes the rate-limiting step indNTP synthesis and is regulated by DNAreplication and DNA damage checkpoint pathwaysvia localization of the small subunits 4e-050.00111 S000003842EAF6YJR082CuncharacterizedEsa1p-associated factor, subunit of the NuA4 acetyltransferasecomplex 4e-050.00111 S000001201KEL1YHR158CverifiedProtein required for proper cell fusion and cell morphology;functions in a complex with Kel2p to negativelyregulate mitotic exit, interacts with Tem1p andLte1p; localizes to regions of polarizedgrowth; potential Cdc28p substrate 4e-050.00111 S000006302YPR098CVerifiedProtein of unknown function, localized to the mitochondrial outer membrane 4e-050.00111 S000002559GIR2YDR152WverifiedHighly-acidic cytoplasmic RWD domain-containing protein ofunknown function, sensitive to proteolysis,N-terminal region has high content of acidicamino acid residues, putative IUP(intrinsically unstructured protein) 4e-050.00111 S000002797SAC7YDR389WverifiedGTPase activating protein (GAP) for Rho1p, involved insignaling to the actin cytoskeleton, nullmutations suppress tor2 mutations andtemperature sensitive mutations in actin;potential Cdc28p substrate 4e-050.00111 S000003661GCD14YJL125CverifiedSubunit of tRNA (1-methyladenosine) methyltransferase, withGcd10p, required for the modification of theadenine at position 58 in tRNAs, especiallytRNAi-Met; first identified as a negativeregulator of GCN4 expression 4e-050.00111 S000004775PAH1YMR165CverifiedMg2+-dependent phosphatidate (PA) phosphatase,catalyzes the dephosphorylation of PA to yielddiacylglycerol and Pi, responsiblefor de novo lipid synthesis; homologous tomammalian lipin 1 4e-050.00111 S000001715MEH1YKR007WverifiedComponent of the EGO complex, which is involved in theregulation of microautophagy, and of the GSEcomplex, which is required for proper sortingof amino acid permease Gap1p; loss results in adefect in vacuolar acidification 4e-050.00111 S000000877PTP3YER075CverifiedPhosphotyrosine-specific protein phosphatase involved in theinactivation of mitogen-activated proteinkinase (MAPK) during osmolarity sensing;dephosporylates Hog1p MAPK and regulates itslocalization; localized to the cytoplasm 4e-050.00111 S000004105CFT2YLR115WverifiedSubunit of the mRNA cleavage and polyadenlylation factor (CPF);required for pre-mRNA cleavage, polyadenylationand poly(A) site recognition, 43% similaritywith the mammalian CPSF-100 protein. 4e-050.00111 S000004428ECM30YLR436CverifiedNon-essential protein of unknown function 4e-050.00111 S000004786PAI3YMR174CverifiedCytoplasmic proteinase A inhibitor, dependent on Pbs2p andHog1p protein kinases for osmotic induction;intrinsically unstructured, N-terminal halfbecomes ordered in the active site ofproteinase A upon contact 4e-050.00111 S000003236PEX31YGR004WverifiedPeroxisomal integral membrane protein, involved in negativeregulation of peroxisome size; partiallyfunctionally redundant with Pex30p and Pex32p;probably acts at a step downstream of stepsmediated by Pex28p and Pex29p 4e-050.00111 S000000484SAF1YBR280CverifiedF-Box protein involved in proteasome-dependent degradation ofAah1p during entry of cells into quiescence;interacts with Skp1 4e-050.00111 S000006190KAR9YPL269WverifiedKaryogamy protein required for correct positioning of themitotic spindle and for orienting cytoplasmicmicrotubules, localizes at the shmoo tip inmating cells and at the tip of the growing budin small-budded cells through anaphase 4e-050.00111 S000005563CYC2YOR037WverifiedMitochondrial peripheral inner membrane protein, contains a FADcofactor in a domain exposed in theintermembrane space; exhibits redox activity invitro; likely participates in ligation of hemeto acytochromes c and c1 (Cyc1p and Cyt1p) 4e-050.00111 S000006164SRP68YPL243WverifiedCore component of the signal recognition particle (SRP)ribonucleoprotein (RNP) complex that functionsin targeting nascent secretory proteins to theendoplasmic reticulum (ER) membrane 4e-050.00111 S000001759YKR051WUncharacterizedHypothetical protein 4e-050.00111 S000001000YHL008CUncharacterizedPutative protein of unknown function, does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole 4e-050.00111 S000005780SEC63YOR254CverifiedEssential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p andSec72p); with Sec61 complex, Kar2p/BiP andLhs1p forms a channel competent forSRP-dependent and post-translationalSRP-independent protein targeting and importinto the ER 4e-050.00111 S000003217PDE1YGL248WverifiedLow-affinity cyclic AMP phosphodiesterase, controls glucose andintracellular acidification-induced cAMPsignaling, target of the cAMP-protein kinase A(PKA) pathway; glucose induces transcriptionand inhibits translation 4e-050.00111 S000004233YLR243WUncharacterizedPutative protein of unknown function; YLR243W is an essential gene 4e-050.00111 S000002494RRP1YDR087CverifiedEssential evolutionarily conserved nucleolar protein necessaryfor biogenesis of 60S ribosomal subunits andprocessing of pre-rRNAs to mature rRNAs,associated with several distinct 66Spre-ribosomal particles 4e-050.00111 S000002151YBL111CUncharacterizedHelicase-like protein encoded within the telomeric Y' element 4e-050.00111 S000000468YPT10YBR264CverifiedGTP binding protein that contains the PEST signal sequencespecific for proteolytic enzymes; may beinvolved in vesicular transport; overexpressionleads to accumulation of Golgi-like cisternaewith budding vesicles 4e-050.00111 S000002939YDR531WUncharacterizedPantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway leading to coenzyme A1 4e-050.00111 S000003366CAF130YGR134WverifiedPart of the evolutionarily-conserved CCR4-NOT transcriptionalregulatory complex involved in controlling mRNAinitiation, elongation, and degradation 4e-050.00111 S000006108MF(ALPHA)1YPL187WverifiedMating pheromone alpha-factor, made by alpha cells; interactswith mating type a cells to induce cell cyclearrest and other responses leading to mating;also encoded by MF(ALPHA)2, although MF(ALPHA)1produces most alpha-factor 4e-050.00111 S000003481MGA1YGR249WverifiedProtein similar to heat shock transcription factor; multicopysuppressor of pseudohyphal growth defects ofammonium permease mutants 4e-050.00111 S000001574YKL091CVerifiedPutative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus 4e-050.00111 S000003936PUF3YLL013CverifiedProtein that regulates degradation of specific mRNAs such asCOX17, binds almost exclusively to cytoplasmicmRNAs encoding mitochondrial proteins, memberof the PUF protein family that contains Pumiliohomology domains 4e-050.00111 S000003300YGR068CUncharacterizedPutative protein of unknown function; YGR068C is not an essential gene. 4e-050.00111 S000000429YBR225WUncharacterizedHypothetical protein 4e-050.00111 S000003541SYS1YJL004CverifiedIntegral membrane protein of the Golgi required for targetingof the Arf-like GTPase Arl3p to the Golgi;multicopy suppressor of ypt6 null mutation 4e-050.00111 S000006284TEF1YPR080WverifiedTranslational elongation factor EF-1 alpha; also encoded byTEF2; functions in the binding reaction ofaminoacyl-tRNA (AA-tRNA) to ribosomes 4e-050.00111 S000000454SPO23YBR250WuncharacterizedProtein of unknown function; associates with meiosis-specificprotein Spo1p 4e-050.00111 S000004095SEN2YLR105CverifiedSubunit of the tRNA splicing endonuclease, which is composed ofSen2p, Sen15p, Sen34p, and Sen54p; Sen2pcontains the active site for tRNA 5' splicesite cleavage and has similarity to Sen34p andto Archaeal tRNA splicing endonuclease 4e-050.00111 S000000499PCA1YBR295WverifiedCadmium transporting P-type ATPase; may also have a role incopper and iron homeostasis; S288C and mostother lab strains contain a G970R mutationwhich eliminates normal cadmium transportfunction 4e-050.00111 S000004223EST1YLR233CverifiedTLC1 RNA-associated factor involved in telomere lengthregulation as the recruitment subunit of thetelomerase holoenzyme, has a possible role inactivating Est2p-TLC1-RNA bound to the telomere 4e-050.00111 S000003962UBI4YLL039CverifiedUbiquitin, becomes conjugated to proteins, marking them forselective degradation via the ubiquitin-26Sproteasome system; essential for the cellularstress response 4e-050.00111 S000005139YNL195CUncharacterizedHypothetical protein 4e-050.00111 S000005911FRE5YOR384WverifiedPutative ferric reductase with similarity to Fre2p; expressioninduced by low iron levels; the authentic,non-tagged protein is detected in highlypurified mitochondria in high-throughputstudies 4e-050.00111 S000002896PAC11YDR488CverifiedDynein intermediate chain, acts in the cytoplasmic dyneinpathway, forms cortical cytoplasmic microtubulecapture site with Num1p; null mutant isdefective in nuclear migration, essential inthe absence of CIN8 4e-050.00111 S000003442YGR210CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 4e-050.00111 S000006297ASR1YPR093CverifiedProtein involved in a putative alcohol-responsive signalingpathway; accumulates in the nucleus underalcohol stress; contains a Ring/PHD fingerdomain 4e-050.00111 S000000130STU1YBL034CverifiedComponent of the mitotic spindle that binds to interpolarmicrotubules via its association withbeta-tubulin (Tub2p); required for interpolarmicrotubules to provide an outward force on thespindle poles 4e-050.00111 S000000183RPL23AYBL087CverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl23Bp and has similarity to E.coli L14 and rat L23 ribosomal proteins 4e-050.00111 S000005354YNR071CUncharacterizedHypothetical protein 4e-050.00111 S000003267YGR035CUncharacterizedPutative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance 4e-050.00111 S000004370SEC61YLR378CverifiedEssential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p);forms a channel for SRP-dependent proteinimport and retrograde transport of misfoldedproteins out of the ER; with Sec63 complexallows SRP-independent protein import into ER 4e-050.00111 S000004907YMR293CUncharacterizedPutative protein similar to bacterial glutamyl-tRNA amidotransferases; may be involved in aerobic respiration; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR293C is not an essential gene 4e-050.00111 S000000010CYS3YAL012WverifiedCystathionine gamma-lyase, catalyzes one of the two reactionsinvolved in the transsulfuration pathway thatyields cysteine from homocysteine with theintermediary formation of cystathionine 4e-050.00111 S000000970CCA1YER168CverifiedATP (CTP):tRNA-specific tRNA nucleotidyltransferase; differentforms targeted to the nucleus, cytosol, andmitochondrion are generated via the use ofmultiple transcriptional and translationalstart sites 4e-050.00111 S000000556LRE1YCL051WverifiedProtein involved in control of cell wall structure and stressresponse; inhibits Cbk1p protein kinaseactivity; overproduction confers resistance tocell-wall degrading enzymes 4e-050.00111 S000000929LCP5YER127WverifiedEssential protein involved in maturation of 18S rRNA; depletionleads to inhibited pre-rRNA processing andreduced polysome levels; localizes primarily tothe nucleolus 4e-050.00111 S000003980JLP1YLL057CuncharacterizedFe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase,involved in sulfonate catabolism for use as asulfur source, contains sequence that closelyresembles a J domain (typified by the E. coliDnaJ protein) 4e-050.00111 S000001339YIL077CUncharacterizedHypothetical protein 4e-050.00111 S000001034YHL042WUncharacterizedPutative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins 4e-050.00111 S000001125SAM35YHR083WverifiedEssential component of the sorting and assembly machinery (SAMcomplex or TOB complex) of the mitochondrialouter membrane, which binds precursors ofbeta-barrel proteins and facilitates theirinsertion into the outer membrane 4e-050.00111 S000001040COS8YHL048WverifiedNuclear membrane protein, member of the DUP380 subfamily ofconserved, often subtelomerically-encodedproteins; regulation suggests a potential rolein the unfolded protein response 4e-050.00111 S000001219FMO1YHR176WverifiedFlavin-containing monooxygenase, localized to the cytoplasmicface of the ER membrane; catalyzes oxidation ofbiological thiols to maintain the ER redoxbuffer ratio for correct folding ofdisulfide-bonded proteins 4e-050.00111 S000002827RAD30YDR419WverifiedDNA polymerase eta, involved in the predominantly error-freebypass replication of DNA lesions, catalyzesthe efficient and accurate synthesis of DNAopposite cyclobutane pyrimidine dimers; homologof human POLH and bacterial DinB proteins 4e-050.00111 S000003897YJR136CUncharacterizedPutative protein of unknown function; may interact with mitochondrial ribosomal protein Rsm23p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 4e-050.00111 S000007588YDL085C-AUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 4e-050.00111 S000003885YJR124CUncharacterizedHypothetical protein 4e-050.00111 S000001378HIS5YIL116WverifiedHistidinol-phosphate aminotransferase, catalyzes the seventhstep in histidine biosynthesis; responsive togeneral control of amino acid biosynthesis;mutations cause histidine auxotrophy andsensitivity to Cu, Co, and Ni salts 4e-050.00111 S000028848YMR175W-AUncharacterizedPutative protein of unknown function 4e-050.00111 S000003551CCT3YJL014WverifiedSubunit of the cytosolic chaperonin Cct ring complex, relatedto Tcp1p, required for the assembly of actinand tubulins in vivo 4e-050.00111 S000003122LYS5YGL154CverifiedPhosphopantetheinyl transferase involved in lysinebiosynthesis; converts inactive apo-form ofLys2p (alpha-aminoadipate reductase) intocatalytically active holo-form byposttranslational addition ofphosphopantetheine 4e-050.00111 S000000967PAB1YER165WverifiedPoly(A) binding protein, part of the 3'-end RNA-processingcomplex, mediates interactions between the 5'cap structure and the 3' mRNA poly(A) tail,involved in control of poly(A) tail length,interacts with translation factor eIF-4G 4e-050.00111 S000005300MAS6YNR017WverifiedEssential protein of the mitochondrial inner membrane,component of the mitochondrial import system 4e-050.00111 S000003973COF1YLL050CverifiedCofilin, promotes actin filament depolarization in apH-dependent manner; binds both actin monomersand filaments and severs filaments , thought tobe regulated by phosphorylation at SER4,ubiquitous and essential in eukaryotes 4e-050.00111 S000003562RRN7YJL025WverifiedProtein involved in the transcription of 35S rRNA genes by RNApolymerase I; component of the core factor (CF)complex also composed of Rrn11p, Rrn6p andTATA-binding protein 4e-050.00111 S000005853MYO2YOR326WverifiedOne of two type V myosin motors (along with MYO4) involved inactin-based transport of cargos; required forthe polarized delivery of secretory vesicles,the vacuole, late Golgi elements, peroxisomes,and the mitotic spindle 4e-050.00111 S000006246PUF2YPR042CverifiedMember of the PUF protein family, which is defined by thepresence of Pumilio homology domains thatconfer RNA binding activity; preferentiallybinds mRNAs encoding membrane-associatedproteins 4e-050.00111 S000003613ICS3YJL077CuncharacterizedProtein of unknown function 4e-050.00111 S000004306CDC3YLR314CverifiedComponent of the septin ring of the mother-bud neck that isrequired for cytokinesis; septins recruitproteins to the neck and can act as a barrierto diffusion at the membrane, and they comprisethe 10nm filaments seen with EM 4e-050.00111 S000006322YPR118WVerifiedMethylthioribose-1-phosphate isomerase, catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway 4e-050.00111 S000000399MSI1YBR195CverifiedSubunit of chromatin assembly factor I (CAF-I), regulates theRAS/cAMP pathway via sequestration of Npr1pkinase; localizes to the nucleus and cytoplasm;homologous to human retinoblastoma bindingproteins RbAp48 and RbAp46 4e-050.00111 S000005438AVO1YOL078WverifiedComponent of a membrane-bound complex containing the Tor2pkinase and other proteins, which may have arole in regulation of cell growth 4e-050.00111 S000005633RGS2YOR107WverifiedNegative regulator of glucose-induced cAMP signaling; directlyactivates the GTPase activity of theheterotrimeric G protein alpha subunit Gpa2p 4e-050.00111 S000004274ECI1YLR284CverifiedPeroxisomal delta3,delta2-enoyl-CoA isomerase, hexamericprotein that converts 3-hexenoyl-CoA totrans-2-hexenoyl-CoA, essential for thebeta-oxidation of unsaturated fatty acids,oleate-induced 4e-050.00111 S000004523SML1YML058WverifiedRibonucleotide reductase inhibitor involved in regulating dNTPproduction; regulated by Mec1p and Rad53pduring DNA damage and S phase 4e-050.00111 S000005879YOR352WUncharacterizedHypothetical protein 4e-050.00111 S000005561SHE4YOR035CverifiedProtein containing a UCS (UNC-45/CRO1/SHE4) domain, binds tomyosin motor domains to regulate myosinfunction; involved in endocytosis, polarizationof the actin cytoskeleton, and asymmetric mRNAlocalization 4e-050.00111 S000028710YOR032W-AUncharacterizedIdentified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 4e-050.00111 S000005506PSF3YOL146WverifiedSubunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), whichis localized to DNA replication origins andimplicated in assembly of the DNA replicationmachinery 4e-050.00111 S000004719FOL3YMR113WverifiedDihydrofolate synthetase, involved in folic acid biosynthesis;catalyzes the conversion of dihydropteroate todihydrofolate in folate coenzyme biosynthesis 4e-050.00111 S000004734SAS2YMR127CverifiedHistone acetyltransferase (HAT) catalytic subunit of the SAScomplex (Sas2p-Sas4p-Sas5p), which acetylatesfree histones and nucleosomes and regulatestranscriptional silencing; member of theMYSTacetyltransferase family 4e-050.00111 S000002441LYS14YDR034CverifiedTranscriptional activator involved in regulation of genes ofthe lysine biosynthesis pathway; requires2-aminoadipate semialdehyde as co-inducer 4e-050.00111 S000003560PET130YJL023CverifiedProtein required for respiratory growth; the authentic,non-tagged protein is detected in highlypurified mitochondria in high-throughputstudies 4e-050.00111 S000000987YER185WUncharacterizedHypothetical protein 4e-050.00111 S000000950SPT15YER148WverifiedTATA-binding protein, general transcription factor thatinteracts with other factors to form thepreinitiation complex at promoters, essentialfor viability 4e-050.00111 S000000478CHK1YBR274WverifiedDNA damage checkpoint effector kinase, mediates mitotic cellcycle arrest via phosphorylation of Pds1p;phosphorylated by checkpoint signal transducerkinase Mec1p; homolog of S. pombe and mammalianChk1 checkpoint kinase 4e-050.00111 S000003025YGL057CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria; null mutant exhibits a growth defect on a non-fermentable (respiratory) carbon source; YGL057C is not an essential gene 4e-050.00111 S000000091YAR068WUncharacterizedputative membrane protein 4e-050.00111 S000000046GEM1YAL048CverifiedEvolutionarily-conserved tail-anchored outer mitochondrialmembrane GTPase which regulates mitochondrialmorphology; cells lacking Gem1p containcollapsed, globular, or grape-likemitochondria; not required forpheromone-induced cell death 4e-050.00111 S000006153SSO1YPL232WverifiedPlasma membrane t-SNARE involved in fusion of secretoryvesicles at the plasma membrane and in vesiclefusion during sporulation; forms a complex withSec9p that binds v-SNARE Snc2p; syntaxinhomolog; functionally redundant with Sso2p 4e-050.00111 S000003783LSM8YJR022WverifiedLsm (Like Sm) protein; forms heteroheptameric complex (withLsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p)that is part of spliceosomal U6 snRNP and isalso implicated in processing of pre-tRNA,pre-snoRNA, and pre-rRNA 4e-050.00111 S000001537DEF1YKL054CverifiedRNAPII degradation factor, forms a complex with Rad26p inchromatin, enables ubiquitination andproteolysis of RNAPII present in an elongationcomplex 4e-050.00111 S000001193PEX28YHR150WverifiedPeroxisomal integral membrane protein, involved in regulationof peroxisome size and number; geneticinteractions suggest that Pex28p and Pex29p actat steps upstream of those mediated by Pex30p,Pex31p, and Pex32p 4e-050.00111 S000007472HUG1YML058W-AverifiedProtein involved in the Mec1p-mediated checkpoint pathway thatresponds to DNA damage or replication arrest,transcription is induced by DNA damage 4e-050.00111 S000028518YCL058W-AUncharacterizedProtein of unknown function; identified by homology to Ashbya gossypii 4e-050.00111 S000000804NOP16YER002WverifiedConstituent of 66S pre-ribosomal particles, involved in 60Sribosomal subunit biogenesis 4e-050.00111 S000000883SER3YER081Wverified3-phosphoglycerate dehydrogenase, catalyzes the first step inserine and glycine biosynthesis; isozyme ofSer33p 4e-050.00111 S000002674YDR266CUncharacterizedHypothetical protein 4e-050.00111 S000000155YBL059WUncharacterizedHypothetical protein 4e-050.00111 S000003201TAN1YGL232WverifiedPutative tRNA acetyltransferase, RNA-binding protein requiredfor the formation of the modified nucleosideN(4)-acetylcytidine in serine and leucine tRNAsbut not required for the same modification in18S rRNA 4e-050.00111 S000005272MDJ2YNL328CverifiedConstituent of the mitochondrial import motor associated withthe presequence translocase; function overlapswith that of Pam18p; stimulates the ATPaseactivity of Ssc1p to drive mitochondrialimport; contains a J domain 4e-050.00111 S000002960YER093C-AUncharacterizedHypothetical protein 4e-050.00111 S000003767SUI2YJR007WverifiedAlpha subunit of the translation initiation factor eIF2,involved in the identification of the startcodon; phosphorylation of Ser51 is required forregulation of translation by inhibiting theexchange of GDP for GTP 4e-050.00111 S000006200YPL279CUncharacterizedHypothetical protein 4e-050.00111 S000003184KIP3YGL216WverifiedKinesin-related motor protein involved in mitotic spindlepositioning 4e-050.00111 S000002897SLD5YDR489WverifiedSubunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), whichis localized to DNA replication origins andimplicated in assembly of the DNA replicationmachinery 4e-050.00111 S000000483PAF1YBR279WverifiedRNA polymerase II-associated protein, defines a large complexthat is biochemically and functionally distinctfrom the Srb-Mediator form of Pol II holoenzymeand is required for full expression of a subsetof cell cycle-regulated genes 4e-050.00111 S000006331YPR127WUncharacterizedHypothetical protein 4e-050.00111 S000006262YMC1YPR058WverifiedPutative mitochondrial inner membrane transporter, member ofthe mitochondrial carrier (MCF) family; theauthentic, non-tagged protein is detected inhighly purified mitochondria in high-throughputstudies 4e-050.00111 S000000552YCL047CUncharacterizedPutative protein of unknown function 4e-050.00111 S000005347YNR064CVerifiedEpoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides 4e-050.00111 S000002984KAP122YGL016WverifiedKaryopherin beta, responsible for import of the Toa1p-Toa2pcomplex into the nucleus; binds to nucleoporinsNup1p and Nup2p; may play a role in regulationof pleiotropic drug resistance 4e-050.00111 S000003691FBP26YJL155CverifiedFructose-2,6-bisphosphatase, required for glucose metabolism 4e-050.00111 S000001924CDC14YFR028CverifiedProtein phosphatase required for mitotic exit; located in thenucleolus until liberated by the FEAR andMitotic Exit Network in anaphase, enabling itto act on key substrates to effect a decreasein CDK/B-cyclin activity and mitotic exit 4e-050.00111 S000000534BIK1YCL029CverifiedMicrotubule-associated protein, component of the interfacebetween microtubules and kinetochore, involvedin sister chromatid separation; essential inpolyploid cells but not in haploid or diploidcells; ortholog of mammalian CLIP-170 4e-050.00111 S000002527TRM1YDR120CverifiedtRNA methyltransferase, localizes to both the nucleus andmitochondrion to produce the modified baseN2,N2-dimethylguanosine in tRNAs in bothcompartments 4e-050.00111 S000001325YRB2YIL063CverifiedProtein of unknown function involved in nuclear processes ofthe Ran-GTPase cycle; involved in nuclearprotein export; contains Ran Binding Domain andFxFG repeats; interacts with Srm1p, GTP-Gsp1p,Rna1p and Crm1p; is not essential 4e-050.00111 S000004854YHM2YMR241WverifiedMitochondrial DNA-binding protein, component of themitochondrial nucleoid structure, involved inmtDNA replication and segregation ofmitochondrial genomes; member of themitochondrial carrier protein family 4e-050.00111 S000003425PDX1YGR193CverifiedDihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) ofthe mitochondrial pyruvate dehydrogenase (PDH)complex, plays a structural role in the complexby binding and positioning E3 to thedihydrolipoamide acetyltransferase (E2) core 4e-050.00111 S000003906RPS4AYJR145CverifiedProtein component of the small (40S) ribosomal subunit;mutation affects 20S pre-rRNA processing;identical to Rps4Bp and has similarity to ratS4 ribosomal protein 4e-050.00111 S000006192ATP15YPL271WverifiedEpsilon subunit of the F1 sector of mitochondrial F1F0 ATPsynthase, which is a large, evolutionarilyconserved enzyme complex required for ATPsynthesis 4e-050.00111 S000001021OCA5YHL029CuncharacterizedCytoplasmic protein required for replication of Brome mosaicvirus in S. cerevisiae, which is a model systemfor studying replication of positive-strand RNAviruses in their natural hosts 4e-050.00111 S000000162SEF1YBL066CverifiedPutative transcription factor, has homolog in Kluyveromyceslactis 4e-050.00111 S000000404BEM1YBR200WverifiedProtein containing SH3-domains, involved in establishing cellpolarity and morphogenesis; functions as ascaffold protein for complexes that includeCdc24p, Ste5p, Ste20p, and Rsr1p 4e-050.00111 S000005211PIK1YNL267WverifiedPhosphatidylinositol 4-kinase; catalyzes first step in thebiosynthesis ofphosphatidylinositol-4,5-biphosphate; maycontrol cytokineses through the actincytoskeleton 4e-050.00111 S000004007MEU1YLR017WverifiedMethylthioadenosine phosphorylase (MTAP), catalyzes the initialstep in the methionine salvage pathway; affectspolyamine biosynthesis through regulation ofornithine decarboxylase (Spe1p) activity;regulates ADH2 gene expression 4e-050.00111 S000001148TRR2YHR106WverifiedMitochondrial thioredoxin reductase involved in protectionagainst oxidative stress, required with Glr1pto maintain the redox state of Trx3p, containsactive-site motif (CAVC) present in prokaryoticthioredoxin reductases, binds NADPH and FAD 4e-050.00111 S000004975HHF2YNL030WverifiedOne of two identical histone H4 proteins (see also HHF1); corehistone required for chromatin assembly andchromosome function; contributes to telomericsilencing; N-terminal domain involved inmaintaining genomic integrity 4e-050.00111 S000001787TRZ1YKR079CverifiedtRNase Z, involved in RNA processing, has two putativenucleotide triphosphate-binding motifs (P-loop)and a conserved histidine motif, homolog of thehuman candidate prostate cancer susceptibilitygene ELAC2 4e-050.00111 S000003543CTK2YJL006CverifiedBeta subunit of C-terminal domain kinase I (CTDK-I), whichphosphorylates the C-terminal repeated domainof the RNA polymerase II large subunit (Rpo21p)to affect both transcription and pre-mRNA 3'end processing; has similarity to cyclins 4e-050.00111 S000006434LSM3YLR438C-AverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 4e-050.00111 S000001092SMF2YHR050WverifiedDivalent metal ion transporter involved in manganesehomeostasis; has broad specificity fordi-valent and tri-valent metals;post-translationally regulated by levels ofmetal ions; member of the Nramp family of metaltransport proteins 4e-050.00111 S000005542ERP4YOR016CverifiedProtein with similarity to Emp24p and Erv25p, member of the p24family involved in ER to Golgi transport 4e-050.00111 S000004693YMR087WVerifiedPutative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain 4e-050.00111 S000005959MET31YPL038WverifiedZinc-finger DNA-binding protein, involved in regulatingexpression of the methionine biosyntheticgenes, similar to Met32p 4e-050.00111 S000002471RPS13YDR064WverifiedProtein component of the small (40S) ribosomal subunit; hassimilarity to E. coli S15 and rat S13 ribosomalproteins 4e-050.00111 S000003873NNF1YJR112WverifiedEssential component of the MIND kinetochore complex (Mtw1pIncluding Nnf1p-Nsl1p-Dsn1p) which joinskinetochore subunits contacting DNA to thosecontacting microtubules; required for accuratechromosome segregation 4e-050.00111 S000001196SPO16YHR153CverifiedProtein of unknown function, required for spore formation 4e-050.00111 S000001113PCL5YHR071WverifiedCyclin, interacts with Pho85p cyclin-dependent kinase (Cdk),induced by Gcn4p at level of transcription,specifically required for Gcn4p degradation,may be sensor of cellular protein biosyntheticcapacity 4e-050.00111 S000005657YOR131CUncharacterizedHypothetical protein 4e-050.00111 S000000058GDH3YAL062WverifiedNADP(+)-dependent glutamate dehydrogenase, synthesizesglutamate from ammonia and alpha-ketoglutarate;rate of alpha-ketoglutarate utilization differsfrom Gdh1p; expression regulated by nitrogenand carbon sources 4e-050.00111 S000000323MUD1YBR119WverifiedU1 snRNP A protein, homolog of human U1-A; involved in nuclearmRNA splicing 4e-050.00111&radic S000003011DST1YGL043WverifiedGeneral transcription elongation factor TFIIS, enables RNApolymerase II to read through blocks toelongation by stimulating cleavage of nascenttranscripts stalled at transcription arrestsites 4e-050.00111 S000005669THI80YOR143CverifiedThiamine pyrophosphokinase, phosphorylates thiamine to producethe coenzyme thiamine pyrophosphate (thiaminediphosphate) 4e-050.00111 S000000608YCR015CUncharacterizedPutative protein of unknown function; YCR015C is not an essential gene 4e-050.00111 S000003667YJL131CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria; YJL131C is a non-essential gene 4e-050.00111 S000002324CDC36YDL165WverifiedComponent of the CCR4-NOT complex, which has multiple roles inregulating mRNA levels including regulation oftranscription and destabilizing mRNAs bydeadenylation; basal transcription factor 4e-050.00111 S000004056SPC3YLR066WverifiedSubunit of signal peptidase complex (Spc1p, Spc2p, Spc3p,Sec11p), which catalyzes cleavage of N-terminalsignal sequences of proteins targeted to thesecretory pathway; homologous to mammalianSPC22/23 4e-050.00111 S000000009SWC3YAL011WverifiedProtein of unknown function, component of the SWR1 complex,which exchanges histone variant H2AZ (Htz1p)for chromatin-bound histone H2A; required forformation of nuclear-associated array of smoothendoplasmic reticulum known as karmellae 4e-050.00111 S000005711GSP2YOR185CverifiedGTP binding protein (mammalian Ranp homolog) involved in themaintenance of nuclear organization, RNAprocessing and transport; interacts withKap121p, Kap123p and Pdr6p (karyophilin betas);Gsp1p homolog that is not required forviability 4e-050.00111 S000005984TIM50YPL063WverifiedConstituent of the mitochondrial inner membrane presequencetranslocase (TIM23 complex); may promotebinding of incoming precursor proteins to theintermembrane space domain of Tom22p duringtranslocation 4e-050.00111 S000007627YOL159C-AUncharacterizedHypothetical protein identified by homology. See FEBS Letters [2000] 487:31-36. 4e-050.00111 S000000792HPA3YEL066WverifiedD-Amino acid N-acetyltransferase, catalyzes N-acetylation ofD-amino acids through ordered bi-bi mechanismin which acetyl-CoA is first substrate boundand CoA is last product liberated; similar toHpa2p, acetylates histones weakly in vitro 4e-050.00111 S000004122YLR132CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to mitochondria and nucleus; YLR132C is an essential gene 4e-050.00111 S000028632YGL007C-AUncharacterizedIdentified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 4e-050.00111 S000002548DOP1YDR141CverifiedProtein of unknown function, essential for viability, involvedin establishing cellular polarity andmorphogenesis; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 4e-050.00111 S000004211RSA3YLR221CverifiedProtein with a likely role in ribosomal maturation, requiredfor accumulation of wild-type levels of large(60S) ribosomal subunits; binds to the helicaseDbp6p in pre-60S ribosomal particles in thenucleolus 4e-050.00111 S000002724OMS1YDR316WverifiedProtein integral to the mitochondrial membrane; has a conservedmethyltransferase motif; multicopy suppressorof respiratory defects caused by OXA1 mutations 4e-050.00111 S000006308FHL1YPR104CverifiedPutative transcriptional regulator with similarity toDNA-binding domain of Drosophila forkhead;required for rRNA processing 4e-050.00111 S000005005NOP2YNL061WverifiedProbable RNA m(5)C methyltransferase, essential for processingand maturation of 27S pre-rRNA and largeribosomal subunit biogenesis; localized to thenucleolus; constituent of 66S pre-ribosomalparticles 4e-050.00111 S000004380RPS29AYLR388WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps29Bp and has similarity to ratS29 and E. coli S14 ribosomal proteins 4e-050.00111 S000003639GSM1YJL103CuncharacterizedPutative zinc cluster protein of unknown function; proposed tobe involved in the regulation of energymetabolism, based on patterns of expression andsequence analysis 4e-050.00111 S000000849SAP1YER047CverifiedPutative ATPase of the AAA family, interacts with the Sin1ptranscriptional repressor in the two-hybridsystem 4e-050.00111 S000002820RRP17YDR412WuncharacterizedProtein required for cell viability 4e-050.00111 S000005191YNL247WUncharacterizedProtein required for cell viability 4e-050.00111 S000001244PPX1YHR201CverifiedExopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P)into Pi residues; located in the cytosol,plasma membrane, and mitochondrial matrix 4e-050.00111 S000006403ARR1YPR199CverifiedTranscriptional activator of the bZIP family, required fortranscription of genes involved in resistanceto arsenic compounds 4e-050.00111 S000004004PPR1YLR014CverifiedZinc finger transcription factor containing a Zn(2)-Cys(6)binuclear cluster domain, positively regulatestranscription of genes involved in uracilbiosynthesis; activity may be modulated byinteraction with Tup1p 4e-050.00111 S000002391OST4YDL232WverifiedSubunit of the oligosaccharyltransferase complex of the ERlumen, which catalyzes proteinasparagine-linked glycosylation; type Imembrane protein required for incorporation ofOst3p or Ost6p into the OST complex 4e-050.00111 S000001703FRE2YKL220CverifiedFerric reductase and cupric reductase, reducessiderophore-bound iron and oxidized copperprior to uptake by transporters; expressioninduced by low iron levels but not by lowcopper levels 4e-050.00111 S000002467MAK21YDR060WverifiedConstituent of 66S pre-ribosomal particles, required for large(60S) ribosomal subunit biogenesis; involved innuclear export of pre-ribosomes; required formaintenance of dsRNA virus; homolog of humanCAATT-binding protein 4e-050.00111&radic S000006433TOM5YPR133W-AverifiedSmall mitochondrial outer membrane protein crucial to a bindingrelay for the import of proteins intomitochondria; subunit on the outer mouth of theTOM channel that accepts precursors from thereceptors Tom20p and Tom22p 4e-050.00111 S000001600SBA1YKL117WverifiedCo-chaperone that binds to and regulates Hsp90 familychaperones; important for pp60v-src activity inyeast; homologous to the mammalian p23 proteins 4e-050.00111 S000001159TOM71YHR117WverifiedMitochondrial outer membrane protein with similarity to Tom70p;probable minor component of the TOM(translocase of outer membrane) complexresponsible for recognition and import ofmitochondrially directed proteins 4e-050.00111 S000000314ALG1YBR110WverifiedMannosyltransferase, involved in asparagine-linkedglycosylation in the endoplasmic reticulum(ER); essential for viability, mutation isfunctionally complemented by human ortholog 4e-050.00111 S000001589AAT1YKL106WverifiedMitochondrial aspartate aminotransferase, catalyzes theconversion of oxaloacetate to aspartate inaspartate and asparagine biosynthesis 4e-050.00111 S000000203YBL107CUncharacterizedHypothetical protein 4e-050.00111 S000001945YMR31YFR049WverifiedMitochondrial ribosomal protein of the small subunit, hassimilarity to human mitochondrial ribosomalprotein MRP-S36 4e-050.00111 S000087203YCL048W-AUncharacterizedPutative protein of unknown function 4e-050.00111 S000005305MRPL50YNR022CverifiedMitochondrial ribosomal protein of the large subunit, notessential for mitochondrial translation 4e-050.00111 S000003615PRY1YJL079CverifiedProtein of unknown function, has similarity to Pry2p and Pry3pand to the plant PR-1 class of pathogen relatedproteins 4e-050.00111 S000005441IRA2YOL081WverifiedGTPase-activating protein that negatively regulates RAS byconverting it from the GTP- to the GDP-boundinactive form, required for reducing cAMPlevels under nutrient limiting conditions, hassimilarity to Ira1p and human neurofibromin 4e-050.00111 S000005068NAF1YNL124WverifiedProtein required for the assembly of box H/ACA snoRNPs and forpre-rRNA processing, forms a complex with Shq1pand interacts with H/ACA snoRNP componentsNhp2p and Cbf5p; has similarity to Gar1p andother RNA-binding proteins 4e-050.00111 S000004048SHM2YLR058CverifiedCytosolic serine hydroxymethyltransferase, involved inone-carbon metabolism 4e-050.00111 S000006132NIP7YPL211WverifiedNucleolar protein required for 60S ribosome subunit biogenesis,constituent of 66S pre-ribosomal particles;physically interacts with Nop8p and the exosomesubunit Rrp43p 4e-050.00111 S000005974KTR6YPL053CverifiedProbable mannosylphosphate transferase involved in thesynthesis of core oligosaccharides in proteinglycosylation pathway; member of the KRE2/MNT1mannosyltransferase family 4e-050.00111 S000006435DID2YKR035W-AverifiedClass E protein of the vacuolar protein-sorting (Vps) pathway,associates reversibly with the late endosome,has human ortholog that may be altered inbreast tumors 4e-050.00109 S000003816HIT1YJR055WverifiedProtein of unknown function, required for growth at hightemperature 4e-050.00109 S000004540HMG1YML075CverifiedOne of two isozymes of HMG-CoA reductase that catalyzes theconversion of HMG-CoA to mevalonate, which is arate-limiting step in sterol biosynthesis;localizes to the nuclear envelope;overproduction induces the formation ofkarmellae 4e-050.00109 S000003646GZF3YJL110CverifiedGATA zinc finger protein and Dal80p homolog that negativelyregulates nitrogen catabolic gene expression bycompeting with Gat1p for GATA site binding;function requires a repressive carbon source;dimerizes with Dal80p and binds to Tor1p 4e-050.00109 S000006256NHP6AYPR052CverifiedHigh-mobility group non-histone chromatin protein, functionallyredundant with Nhp6Bp; homologous to mammalianhigh mobility group proteins 1 and 2; acts torecruit transcription factor Rcs1p to certainpromoters 4e-050.00109 S000007606YFR012W-AUncharacterizedPutative protein of unknown function; identified by homology 4e-050.00109 S000002980ERG4YGL012WverifiedC-24(28) sterol reductase, catalyzes the final step inergosterol biosynthesis; mutants are viable,but lack ergosterol 4e-050.00109 S000003689INO1YJL153CverifiedInositol 1-phosphate synthase, involved in synthesis ofinositol phosphates and inositol-containingphospholipids; transcription is coregulatedwith other phospholipid biosynthetic genes byIno2p and Ino4p, which bind the UASINO DNAelement 4e-050.00109 S000001570CYT2YKL087CverifiedCytochrome c1 heme lyase, involved in maturation of cytochromec1, which is a subunit of the mitochondrialubiquinol-cytochrome-c reductase; links hemecovalently to apocytochrome c1 4e-050.00109 S000002994TRP5YGL026CverifiedTryptophan synthase involved in tryptophan biosynthesis,regulated by the general control system ofamino acid biosynthesis 4e-050.00109 S000000971RPH1YER169WverifiedTranscriptional repressor of PHR1, which is a photolyaseinduced by DNA damage; binds to AG(4) (C(4)T)sequence upstream of PHR1; Rph1pphosphorylation during DNA damage is undercontrol of the MEC1-RAD53 pathway 4e-050.00109 S000000539LSB5YCL034WverifiedProtein of unknown function; binds Las17p, which is a homologof human Wiskott-Aldrich Syndrome proteininvolved in actin patch assembly and actinpolymerization 4e-050.00109 S000003597NUP82YJL061WverifiedSubunit of the nuclear pore complex (NPC), forms a subcomplexwith Nup159p and Nsp1p, interacts with Nup116pand is required for proper localization ofNup116p in the NPC 4e-050.00109 S000000393RPS9BYBR189WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps9Ap and has similarity to E.coli S4 and rat S9 ribosomal proteins 4e-050.00109 S000001750UTH1YKR042WverifiedMitochondrial outer membrane and cell wall localized SUN familymember required for mitochondrial autophagy;involved in the oxidative stress response, lifespan during starvation, mitochondrialbiogenesis, and cell death 4e-050.00109 S000000702ADH7YCR105WverifiedNADPH-dependent cinnamyl alcohol dehydrogenase family memberwith broad substrate specificity; may beinvolved in fusel alcohol synthesis 4e-050.00109 S000004044OSW2YLR054CuncharacterizedProtein of unknown function proposed to be involved in theassembly of the spore wall 4e-050.00109 S000000307SIF2YBR103WverifiedWD40 repeat-containing subunit of the Set3C histone deacetylasecomplex, which represses early/middlesporulation genes; antagonizes telomericsilencing; binds specifically to the Sir4pN-terminus 4e-050.00109 S000005686MTR10YOR160WverifiedNuclear import receptor, mediates the nuclear localization ofproteins involved in mRNA-nucleus export 4e-050.00109 S000005912YOR385WUncharacterizedHypothetical protein 4e-050.00109 S000005052YNL108CUncharacterizedPutative protein of unknown function with similarity to TFC7 and phosphotranfer enzymes in prokaryotes; a deletion mutant shows alterations in glucose metabolism; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 4e-050.00109 S000000373SSE2YBR169CverifiedMember of the heat shock protein 70 (HSP70) family; may beinvolved in protein folding; localized to thecytoplasm; highly homologous to the heat shockprotein Sse1p 4e-050.00109 S000000822GPA2YER020WverifiedNucleotide binding alpha subunit of the heterotrimeric Gprotein that interacts with the receptor Gpr1p,has signaling role in response to nutrients;green fluorescent protein (GFP)-fusion proteinlocalizes to the cell periphery 4e-050.00109 S000006173YAH1YPL252CverifiedFerredoxin of the mitochondrial matrix required for formationof cellular iron-sulfur proteins; involved inheme A biosynthesis; homologous to humanadrenodoxin 4e-050.00109 S000003928SPO75YLL005CverifiedMeiosis-specific protein of unknown function, required forspore wall formation during sporulation;dispensable for both nuclear divisions duringmeiosis 4e-050.00109 S000002279YDL121CUncharacterizedHypothetical protein 4e-050.00109&radic S000004611ADI1YMR009WverifiedAcireductone dioxygenease involved in the methionine salvagepathway; ortholog of human MTCBP-1; transcribedwith YMR010W and regulatedpost-transcriptionally by RNase III (Rnt1p)cleavage; ADI1 mRNA is induced in heat shockconditions 4e-050.00109 S000001195SPO12YHR152WverifiedNucleolar protein of unknown function, positive regulator ofexit from mitosis; involved in regulating therelease of Cdc14p from the nucleolus in earlyanaphase; proposed to play similar role inmeiosis 4e-050.00109 S000000450YBR246WUncharacterizedHypothetical protein 4e-050.00109 S000000434OM14YBR230CverifiedIntegral mitochondrial outer membrane protein; abundance isdecreased in cells grown in glucose relative toother carbon sources; appears to contain 3alpha-helical transmembrane segments; ORFencodes a 97-basepair intron 4e-050.00109 S000003500HUA1YGR268CuncharacterizedCytoplasmic protein containing a zinc finger domain withsequence similarity to that of Type IJ-proteins; computational analysis oflarge-scale protein-protein interaction datasuggests a possible role in actin patchassembly 4e-050.00109 S000005975LEE1YPL054WverifiedZinc-finger protein of unknown function 4e-050.00109 S000000308YMC2YBR104WverifiedPutative mitochondrial inner membrane transporter, member ofthe mitochondrial carrier (MCF) family 4e-050.00109 S000005536TIR2YOR010CverifiedPutative cell wall mannoprotein of the Srp1p/Tip1p family ofserine-alanine-rich proteins; transcription isinduced by cold shock and anaerobiosis 4e-050.00109 S000028597YBL071C-BUncharacterizedPutative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 4e-050.00109 S000000251FMP23YBR047WuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 4e-050.00109 S000004396YLR404WUncharacterizedPutative protein of unknown function; may be an integral membrane protein; YLR404W is not an essential gene 4e-050.00109 S000006180APM1YPL259CverifiedMu1-like medium subunit of the clathrin-associated proteincomplex (AP-1); binds clathrin; involved inclathrin-dependent Golgi protein sorting 4e-050.00109 S000004955YNL010WUncharacterizedPutative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation 4e-050.00109 S000001277BAR1YIL015WverifiedAspartyl protease secreted into the periplasmic space of matingtype a cells, helps cells find mating partners,cleaves and inactivates alpha factor allowingcells to recover from alpha-factor-induced cellcycle arrest 4e-050.00109 S000000597YCP4YCR004CverifiedProtein of unknown function, has sequence and structuralsimilarity to flavodoxins; the authentic,non-tagged protein is detected in highlypurified mitochondria in high-throughputstudies 4e-050.00109 S000000996MRP4YHL004WverifiedMitochondrial ribosomal protein of the small subunit 4e-050.00109 S000002872SPP41YDR464WverifiedProtein involved in negative regulation of expression ofspliceosome components PRP4 and PRP3 4e-050.00109 S000006051SPO19YPL130WverifiedMeiosis-specific protein of unknown function, involved incompletion of nuclear divisions; identified asa weak high-copy suppressor of the spo1-1 tsmutation; putative GPI-dependent cell-wallprotein 4e-050.00109 S000004296STT4YLR305CverifiedPhosphatidylinositol-4-kinase that functions in the Pkc1pprotein kinase pathway; required for normalvacuole morphology, cell wall integrity, andactin cytoskeleton organization 4e-050.00109 S000005090YNL146WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene 4e-050.00109 S000001018YHL026CUncharacterizedPutative protein of unknown function; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History) 4e-050.00109 S000005153SSB2YNL209WverifiedCytoplasmic ATPase that is a ribosome-associated molecularchaperone, functions with J-protein partnerZuo1p; may be involved in the folding ofnewly-synthesized polypeptide chains; member ofthe HSP70 family; homolog of SSB1 4e-050.00109 S000000895TSC11YER093CverifiedSubunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), amembrane-associated complex that regulatesactin cytoskeletal dynamics during polarizedgrowth and cell wall integrity; involved insphingolipid metabolism; contains a RasGEFNdomain 4e-050.00109 S000005822YOR296WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene 4e-050.00109 S000003682IDS2YJL146WverifiedProtein involved in modulation of Ime2p activity duringmeiosis, appears to act indirectly to promoteIme2p-mediated late meiotic functions; found ingrowing cells and degraded during sporulation 4e-050.00109 S000003670LCB3YJL134WverifiedLong-chain base-1-phosphate phosphatase, regulates ceramide andlong-chain base phosphates levels, involved inincorporation of exogenous long chain bases insphingolipids 4e-050.00109 S000004764YMR155WUncharacterizedHypothetical protein 4e-050.00109 S000005125YNL181WUncharacterizedProtein required for cell viability 4e-050.00109 S000002982PUF4YGL014WverifiedMember of the PUF protein family, which is defined by thepresence of Pumilio homology domains thatconfer RNA binding activity; preferentiallybinds mRNAs encoding nucleolar ribosomalRNA-processing factors 4e-050.00109 S000002889PHO8YDR481CverifiedRepressible alkaline phosphatase, a glycoprotein localized tothe vacuole; regulated by levels of inorganicphosphate and by a system consisting of Pho4p,Pho9p, Pho80p, Pho81p and Pho85p;dephosphorylates phosphotyrosyl peptides 4e-050.00109 S000005349YNR066CUncharacterizedHypothetical protein 4e-050.00109 S000003376THI4YGR144WverifiedProtein required for thiamine biosynthesis and formitochondrial genome stability 4e-050.00109 S000001789RPF2YKR081CverifiedEssential protein involved in the processing of pre-rRNA andthe assembly of the 60S ribosomal subunit;interacts with ribosomal protein L11; localizespredominantly to the nucleolus; constituent of66S pre-ribosomal particles 4e-050.00109 S000006239GLN1YPR035WverifiedGlutamine synthetase (GS), synthesizes glutamine from glutamateand ammonia; with Glt1p, forms the secondarypathway for glutamate biosynthesis fromammonia; expression regulated by nitrogensource and by amino acid limitation 4e-050.00109 S000005047MET4YNL103WverifiedLecine-zipper transcriptional activator, responsible for theregulation of the sulfur amino acid pathway,requires different combinations of theauxiliary factors Cbf1p, Met28p, Met31p andMet32p 4e-050.00109 S000004595ERG13YML126Cverified3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzesthe formation of HMG-CoA from acetyl-CoA andacetoacetyl-CoA; involved in the second step inmevalonate biosynthesis 4e-050.00109 S000000368ARL1YBR164CverifiedSoluble GTPase with a role in regulation of membrane traffic;regulates potassium influx; G protein of theRas superfamily, similar to ADP-ribosylationfactor 4e-050.00109 S000007607YGL258W-AUncharacterizedPutative protein of unknown function 4e-050.00109 S000001856YPT1YFL038CverifiedRas-like small GTPase, involved in the ER-to-Golgi step of thesecretory pathway; complex formation with theRab escort protein Mrs6p is required forprenylation of Ypt1p by proteingeranylgeranyltransferase type II (Bet2p-Bet4p) 4e-050.00109 S000001546YKL063CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi 4e-050.00109 S000001205YHR162WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion 4e-050.00109 S000001247MNL1YHR204WverifiedAlpha mannosidase-like protein of the endoplasmic reticulumrequired for degradation of glycoproteins butnot for processing of N-linked oligosaccharides 4e-050.00109 S000005029MKT1YNL085WverifiedProtein that forms a complex with Pbp1p that may mediateposttranscriptional regulation of HOendonuclease; involved in propagation of M2dsRNA satellite of L-A virus 4e-050.00109 S000001085DOG2YHR043Cverified2-deoxyglucose-6-phosphate phosphatase, member of a family oflow molecular weight phosphatases, similar toDog1p, induced by oxidative and osmotic stress,confers 2-deoxyglucose resistance whenoverexpressed 4e-050.00109 S000001221STB5YHR178WverifiedActivator of multidrug resistance genes, forms a heterodimerwith Pdr1p; contains a Zn(II)2Cys6 zinc fingerdomain that interacts with a PDRE (pleotropicdrug resistance element) in vitro; binds Sin3pin a two-hybrid assay 4e-050.00109 S000000045SPC72YAL047CverifiedComponent of the cytoplasmic Tub4p (gamma-tubulin) complex,binds spindle pole bodies and links them tomicrotubules; has roles in astral microtubuleformation and stabilization 4e-050.00109 S000005553STI1YOR027WverifiedHsp90 cochaperone, interacts with the Ssa group of thecytosolic Hsp70 chaperones; activates theATPase activity of Ssa1p; homolog of mammalianHop protein 4e-050.00109 S000006390PZF1YPR186CverifiedTranscription factor IIIA (TFIIIA), essential protein with nineC2H2 Zn-fingers, binds the 5S rRNA gene throughthe zinc finger domain and directs assembly ofa multiprotein initiation complex for RNApolymerase III; also binds DNA 4e-050.00109 S000004359RPS22BYLR367WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps22Ap and has similarity to E.coli S8 and rat S15a ribosomal proteins 4e-050.00109 S000002257BUG1YDL099WuncharacterizedProtein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to the cytoplasmin a punctate pattern 4e-050.00109 S000000837EDC2YER035WverifiedRNA-binding protein, activates mRNA decapping directly bybinding to the mRNA substrate and enhancing theactivity of the decapping proteins Dcp1p andDcp2p 4e-050.00109 S000006167RBD2YPL246CverifiedPossible rhomboid protease, has similarity to eukaryoticrhomboid proteases including Pcp1p 4e-050.00109 S000001793MRPL20YKR085CverifiedMitochondrial ribosomal protein of the large subunit 4e-050.00109 S000002977LEU1YGL009CverifiedIsopropylmalate isomerase, catalyzes the second step in theleucine biosynthesis pathway 4e-050.00109 S000007592PAU9YBL108C-AuncharacterizedHypothetical protein identified by homology. See FEBS Letters[2000] 487:31-36. 4e-050.00109 S000007521TSC3YBR058C-AverifiedProtein that stimulates the activity of serinepalmitoyltransferase (Lcb1p, Lcb2p)several-fold; involved in sphingolipidbiosynthesis 4e-050.00109 S000005110BNI5YNL166CverifiedProtein involved in organization of septins at the mother-budneck, may interact directly with the Cdc11pseptin, localizes to bud neck in aseptin-dependent manner 4e-050.00109 S000004938FET4YMR319CverifiedLow-affinity Fe(II) transporter of the plasma membrane 4e-050.00109 S000005572DBP5YOR046CverifiedCytoplasmic ATP-dependent RNA helicase of the DEAD-box familyinvolved in mRNA export from the nucleus 4e-050.00109 S000006255MAK3YPR051WverifiedCatalytic subunit of N-terminal acetyltransferase of the NatCtype; required for replication of dsRNA virus 4e-050.00109 S000006013SSU1YPL092WverifiedPlasma membrane sulfite pump involved in sulfite metabolism andrequired for efficient sulfite efflux; majorfacilitator superfamily protein 4e-050.00109 S000003479CPD1YGR247WverifiedCyclic nucleotide phosphodiesterase, hydrolyzes ADP-ribose 1'',2''-cyclic phosphate to ADP-ribose1''-phosphate; no detectable phenotype isconferred by null mutation or by overexpression 4e-050.00109 S000005449HAL9YOL089CverifiedPutative transcription factor containing a zinc finger;overexpression increases salt tolerance throughincreased expression of the ENA1 (Na+/Li+extrusion pump) gene while gene disruptiondecreases both salt tolerance and ENA1expression 4e-050.00109 S000001056SPO13YHR014WverifiedMeiosis-specific protein, involved in maintaining sisterchromatid cohesion during meiosis I as well aspromoting proper attachment of kinetochores tothe spindle during meiosis I and meiosis II 4e-050.00109 S000004078GAA1YLR088WverifiedSubunit of the GPI (glycosylphosphatidylinositol):proteintransamidase complex, removes the GPI-anchoringsignal and attaches GPI to proteins in the ER 4e-050.00109 S000003699YJL163CUncharacterizedHypothetical protein 4e-050.00109 S000002582RSM24YDR175CverifiedMitochondrial ribosomal protein of the small subunit 4e-050.00109 S000000452HIS7YBR248CverifiedImidazole glycerol phosphate synthase (glutamineamidotransferase:cyclase), catalyzes the fifthand sixth steps of histidine biosynthesis andalso produces 5-aminoimidazole-4-carboxamideribotide (AICAR), a purine precursor 4e-050.00109 S000000529KCC4YCL024WverifiedProtein kinase of the bud neck involved in the septincheckpoint, associates with septin proteins,negatively regulates Swe1p by phosphorylation,shows structural homology to bud neck kinasesGin4p and Hsl1p 4e-050.00109 S000003127YGL159WUncharacterizedPutative protein of unknown function; deletion mutant has no detectable phenotype 4e-050.00109 S000001132YNG2YHR090CverifiedSubunit of the NuA4 histone acetyltransferase complex thatacetylates histone H4 and H2A; has similarityto the human tumor suppressor ING1 4e-050.00109 S000000916BOI2YER114CverifiedProtein implicated in polar growth, functionally redundant withBoi1p; interacts with bud-emergence proteinBem1p; contains an SH3 (src homology 3) domainand a PH (pleckstrin homology) domain 4e-050.00109 S000003712SWI3YJL176CverifiedSubunit of the SWI/SNF chromatin remodeling complex, whichregulates transcription by remodelingchromosomes; required for transcription of manygenes, including ADH1, ADH2, GAL1, HO, INO1 andSUC2 4e-050.00109 S000002448RSM10YDR041WverifiedMitochondrial ribosomal protein of the small subunit, hassimilarity to E. coli S10 ribosomal protein;essential for viability, unlike most othermitoribosomal proteins 4e-050.00109 S000004715MYO5YMR109WverifiedOne of two type I myosins; contains proline-rich tail homology2 (TH2) and SH3 domains; MYO5 deletion haslittle effect on growth, but myo3 myo5 doubledeletion causes severe defects in growth andactin cytoskeleton organization 4e-050.00109 S000004960PBI2YNL015WverifiedCytosolic inhibitor of vacuolar proteinase B, required forefficient vacuole inheritance; with thioredoxinforms protein complex LMA1, which assists inpriming SNARE molecules and promotes vacuolefusion 4e-050.00109 S000004156SEC10YLR166CverifiedEssential 100kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which has the essential function ofmediating polarized targeting of secretoryvesicles to active sites of exocytosis 4e-050.00109 S000003692SSY5YJL156CverifiedProbable serine protease of the SPS plasma membrane amino acidsensor system (Ssy1p-Ptr3p-Ssy5p), which sensesexternal amino acid concentration and transmitsintracellular signals that regulate expressionof amino acid permease genes 4e-050.00109 S000001499ATP7YKL016CverifiedSubunit d of the stator stalk of mitochondrial F1F0 ATPsynthase, which is a large, evolutionarilyconserved enzyme complex required for ATPsynthesis 4e-050.00109 S000003221RTG2YGL252CverifiedSensor of mitochondrial dysfunction; regulates the subcellularlocation of Rtg1p and Rtg3p, transcriptionalactivators of the retrograde (RTG) and TORpathways; Rtg2p is inhibited by thephosphorylated form of Mks1p 4e-050.00109 S000003977YLL054CUncharacterizedPutative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene 4e-050.00109 S000006101TCO89YPL180WverifiedSubunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complexthat regulates growth in response to nutrientavailability; cooperates with Ssd1p in themaintenance of cellular integrity; deletionstrains are hypersensitive to rapamycin 4e-050.00109 S000000416NGR1YBR212WverifiedRNA binding protein that negatively regulates growth rate;interacts with the 3' UTR of the mitochondrialporin (POR1) mRNA and enhances its degradation;overexpression impairs mitochondrial function;expressed in stationary phase 4e-050.00109 S000000903AST2YER101CverifiedProtein that may have a role in targeting of plasma membrane[H+]ATPase (Pma1p) to the plasma membrane, assuggested by analysis of genetic interactions 4e-050.00109 S000004550TUB1YML085CverifiedAlpha-tubulin; associates with beta-tubulin (Tub2p) to formtubulin dimer, which polymerizes to formmicrotubules 4e-050.00109 S000005937SWI1YPL016WverifiedSubunit of the SWI/SNF chromatin remodeling complex, whichregulates transcription by remodelingchromosomes; required for transcription of manygenes, including ADH1, ADH2, GAL1, HO, INO1 andSUC2 4e-050.00109 S000005098YCK2YNL154CverifiedPalmitoylated, plasma membrane-bound casein kinase I isoform;shares redundant functions with Yck1p inmorphogenesis, proper septin assembly,endocytic trafficking; provides an essentialfunction overlapping with that of Yck1p 4e-050.00109 S000003452MRPL9YGR220CverifiedMitochondrial ribosomal protein of the large subunit 4e-050.00109 S000002622AHA1YDR214WverifiedCo-chaperone that binds to Hsp82p and activates its ATPaseactivity; similar to Hch1p; expression isregulated by stresses such as heat shock 4e-050.00109 S000004671UBX4YMR067CuncharacterizedUBX (ubiquitin regulatory X) domain-containing protein thatinteracts with Cdc48p 4e-050.00109 S000003583RTT101YJL047CverifiedCullin subunit of a Roc1p-dependent E3 ubiquitin ligasecomplex; deletion phenotype suggests a role inanaphase progression; interacts with Mms22p andimplicated in Mms22-dependent DNA repair;modified by the ubiquitin-like protein, Rub1p 4e-050.00109 S000005732NOC2YOR206WverifiedProtein that forms a nucleolar complex with Mak21p that bindsto 90S and 66S pre-ribosomes, as well as anuclear complex with Noc3p that binds to 66Spre-ribosomes; both complexes mediateintranuclear transport of ribosomal precursors 4e-050.00109 S000003315GCD2YGR083CverifiedDelta subunit of the translation initiation factor eIF2B, theguanine-nucleotide exchange factor for eIF2;activity subsequently regulated byphosphorylated eIF2; first identified as anegative regulator of GCN4 expression 4e-050.00109 S000001248SCH9YHR205WverifiedProtein kinase that regulates signal transduction activity andG1 progression, controls cAPK activity,required for nitrogen activation of the FGMpathway, involved in life span regulation,homologous to mammalian Akt/PKB 4e-050.00109 S000005202DSL1YNL258CverifiedEndoplasmic reticulum (ER)-localized peripheral membraneprotein required for Golgi-to-ER retrogradetraffic; component of the ER target site thatinteracts with coatomer, the major component ofthe COPI vesicle protein coat 4e-050.00109 S000001633MCR1YKL150WverifiedMitochondrial NADH-cytochrome b5 reductase, involved inergosterol biosynthesis 4e-050.00109 S000002403THI13YDL244WverifiedProtein involved in synthesis of the thiamine precursorhydroxymethylpyrimidine (HMP); member of asubtelomeric gene family including THI5, THI11,THI12, and THI13 4e-050.00109 S000002616MSS4YDR208WverifiedPhosphatidylinositol-4-phosphate 5-kinase, involved in actincytoskeleton organization and cellmorphogenesis; multicopy suppressor of stt4mutation 4e-050.00109 S000004640MSN2YMR037CverifiedTranscriptional activator related to Msn4p; activated in stressconditions, which results in translocation fromthe cytoplasm to the nucleus; binds DNA atstress response elements of responsive genes,inducing gene expression 4e-050.00109 S000006187DIM1YPL266WverifiedEssential 18S rRNA dimethylase, responsible for conservedm6(2)Am6(2)A dimethylation in 3'-terminal loopof 18 S rRNA, part of 90S and 40S pre-particlesin nucleolus, involved in pre-ribosomal RNAprocessing 4e-050.00109 S000003744NUC1YJL208CverifiedMajor mitochondrial nuclease, has RNAse and DNA endo- andexonucleolytic activities; has a role inmitochondrial recombination 4e-050.00109 S000000426PCS60YBR222CverifiedPeroxisomal AMP-binding protein, localizes to both theperoxisomal peripheral membrane and matrix,expression is highly inducible by oleic acid,similar to E. coli long chain acyl-CoAsynthetase 4e-050.00109 S000006016EEB1YPL095CverifiedAcyl-coenzymeA:ethanol O-acyltransferase responsible for themajor part of medium-chain fatty acid ethylester biosynthesis during fermentation;possesses short chain esterase activity; may beinvolved in lipid metabolism and detoxification 4e-050.00109 S000001484MET14YKL001CverifiedAdenylylsulfate kinase, required for sulfate assimilation andinvolved in methionine metabolism 4e-050.00109 S000005733RET1YOR207CverifiedSecond-largest subunit of RNA polymerase III, which isresponsible for the transcription of tRNA and5S RNA genes, and other low molecular weightRNAs 4e-050.00109 S000005486MDH2YOL126CverifiedCytoplasmic malate dehydrogenase, one of the three isozymesthat catalyze interconversion of malate andoxaloacetate; involved in gluconeogenesisduring growth on ethanol or acetate as carbonsource; interacts with Pck1p and Fbp1p 4e-050.00109 S000003252VMA7YGR020CverifiedSubunit F of the eight-subunit V1 peripheral membrane domain ofvacuolar H+-ATPase (V-ATPase), an electrogenicproton pump found throughout the endomembranesystem; required for the V1 domain to assembleonto the vacuolar membrane 4e-050.00109 S000005599SGO1YOR073WverifiedComponent of the spindle checkpoint, involved in sensing lackof tension on mitotic chromosomes; protectscentromeric Rec8p at meiosis I; required foraccurate chromosomal segregation at meiosis IIand for mitotic chromosome stability 4e-050.00109 S000002671DIN7YDR263CverifiedMitochondrial nuclease functioning in DNA repair andreplication, modulates the stability of themitochondrial genome, induced by exposure tomutagens, also induced during meiosis at a timenearly coincident with commitment torecombination 4e-050.00109 S000002743MSN5YDR335WverifiedKaryopherin involved in nuclear import and export; shown to beresponsible for nuclear import of replicationprotein A and for export of several proteinsincluding Swi6p, Far1p, and Pho4p; cargodissociation involves binding to RanGTP 4e-050.00109 S000005838HSD1YOR311CverifiedEndoplasmic reticulum (ER)-resident membrane protein,overproduction induces enlargement of ER-likemembrane structures and suppresses atemperature-sensitive sly1 mutation 4e-050.00109 S000003311YGR079WUncharacterizedPutative protein of unknown function; YGR079W is not an essential gene 4e-050.00109 S000000502MAL31YBR298CverifiedMaltose permease, high-affinity maltose transporter(alpha-glucoside transporter); encoded in theMAL3 complex locus; member of the 12transmembrane domain superfamily of sugartransporters; functional in genomic referencestrain S288C 4e-050.00109 S000005075TOM22YNL131WverifiedComponent of the TOM (translocase of outer membrane) complexresponsible for initial import ofmitochondrially directed proteins; acts as areceptor for precursor proteins and mediatesinteraction between the TOM and TIM complexes 4e-050.00109 S000001233ERG9YHR190WverifiedFarnesyl-diphosphate farnesyl transferase (squalene synthase),joins two farnesyl pyrophosphate moieties toform squalene in the sterol biosynthesispathway 4e-050.00109 S000113563YKL065W-AUncharacterizedPutative protein of unknown function 4e-050.00109 S000028437SLO1YER180C-AverifiedProtein interacting with Arl3p, which is a GTPase of the Rassuperfamily involved in vesicle-tethering atthe Golgi; putative ortholog of human SCOCO 4e-050.00109 S000001663RPL17AYKL180WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl17Bp and has similarity to E.coli L22 and rat L17 ribosomal proteins;copurifies with the Dam1 complex (aka DASHcomplex) 4e-050.00109 S000003028YBP2YGL060WverifiedProtein with a role in resistance to oxidative stress; hassimilarity to Ybp1p, which is involved inregulation of the transcription factor Yap1pvia oxidation of specific cysteine residues 4e-050.00109 S000005080EAF7YNL136WverifiedSubunit of the NuA4 histone acetyltransferase complex, whichacetylates the N-terminal tails of histones H4and H2A 4e-050.00109 S000006393SKI3YPR189WverifiedProtein involved in exosome mediated 3' to 5' mRNA degradationand translation inhibition of non-poly(A)mRNAs; forms complex with Ski2p and Ski8p;required for repressing propagation of dsRNAviruses 4e-050.00109 S000007608YGR271C-AUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus 4e-050.00109 S000004809YMR196WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene 4e-050.00109 S000004659BUB2YMR055CverifiedMitotic exit network regulator, forms GTPase-activatingBfa1p-Bub2p complex that binds Tem1p andspindle pole bodies, blocks cell cycleprogression before anaphase in response tospindle and kinetochore damage 4e-050.00109 S000002996SCW11YGL028CverifiedCell wall protein with similarity to glucanases; may play arole in conjugation during mating based on itsregulation by Ste12p 4e-050.00109 S000004731YMR124WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene 4e-050.00109 S000007232STF1YDL130W-AverifiedProtein involved in regulation of the mitochondrial F1F0-ATPsynthase; Stf1p and Stf2p act as stabilizingfactors that enhance inhibitory action of theInh1p protein 4e-050.00109 S000003606YJL070CUncharacterizedPutative protein of unknown function with similarity to AMP deaminases; YJL070C is a non-essential gene 4e-050.00109 S000005060DMA2YNL116WverifiedProtein involved in regulating spindle position andorientation, functionally redundant with Dma1p;homolog of S. pombe Dma1 and H. sapiens Chfr 4e-050.00109 S000004373CTF3YLR381WverifiedOuter kinetochore protein that forms a complex with Mcm16p andMcm22p; may bind the kinetochore to spindlemicrotubules 4e-050.00109 S000001701SRY1YKL218Cverified3-hydroxyaspartate dehydratase, deaminatesL-threo-3-hydroxyaspartate to form oxaloacetateand ammonia; required for survival in thepresence of hydroxyaspartate 4e-050.00109 S000001925PTR3YFR029WverifiedComponent of the SPS plasma membrane amino acid sensor system(Ssy1p-Ptr3p-Ssy5p), which senses externalamino acid concentration and transmitsintracellular signals that result in regulationof expression of amino acid permease genes 4e-050.00109 S000003866ADO1YJR105WverifiedAdenosine kinase, required for the utilization ofS-adenosylmethionine (AdoMet); may be involvedin recycling adenosine produced through themethyl cycle 4e-050.00109 S000001526PHD1YKL043WverifiedTranscriptional activator that enhances pseudohyphal growth;regulates expression of FLO11, an adhesinrequired for pseudohyphal filament formation;similar to StuA, an A. nidulans developmentalregulator; potential Cdc28p substrate 4e-050.00109 S000005854SNC2YOR327CverifiedVesicle membrane receptor protein (v-SNARE) involved in thefusion between Golgi-derived secretory vesicleswith the plasma membrane; member of thesynaptobrevin/VAMP family of R-type v-SNAREproteins 4e-050.00109 S000005663SIA1YOR137CverifiedProtein of unassigned function involved in activation of thePma1p plasma membrane H+-ATPase by glucose 4e-050.00109 S000001739SPO14YKR031CverifiedPhospholipase D, catalyzes the hydrolysis ofphosphatidylcholine, producing choline andphosphatidic acid; involved inSec14p-independent secretion; required formeiosis and spore formation; differentlyregulated in secretion and meiosis 4e-050.00109 S000002799YDR391CUncharacterizedHypothetical protein 4e-050.00109 S000004580CTK3YML112WverifiedGamma subunit of C-terminal domain kinase I (CTDK-I), whichphosphorylates the C-terminal repeated domainof the RNA polymerase II large subunit (Rpo21p)to affect both transcription and pre-mRNA 3'end processing 4e-050.00109 S000000643BUD23YCR047CverifiedProtein involved in bud-site selection; diploid mutants displaya random budding pattern instead of thewild-type bipolar pattern 4e-050.00109 S000005037YPT53YNL093WverifiedGTPase, similar to Ypt51p and Ypt52p and to mammalian rab5;required for vacuolar protein sorting andendocytosis 4e-050.00109 S000004128NHA1YLR138WverifiedNa+/H+ antiporter involved in sodium and potassium effluxthrough the plasma membrane; required foralkali cation tolerance at acidic pH 4e-050.00109 S000007488YBL059C-AUncharacterizedHypothetical protein 4e-050.00109 S000005437BRX1YOL077CverifiedNucleolar protein, constituent of 66S pre-ribosomal particles;depletion leads to defects in rRNA processingand a block in the assembly of large ribosomalsubunits; possesses a sigma(70)-likeRNA-binding motif 4e-050.00109 S000001723YKR015CUncharacterizedPutative protein of unknown function 4e-050.00109 S000003008HEM2YGL040CverifiedDelta-aminolevulinate dehydratase, a homo-octameric enzyme,catalyzes the conversion ofdelta-aminolevulinic acid to porphobilinogen,the second step in the heme biosyntheticpathway; localizes to both the cytoplasm andnucleus 4e-050.00109 S000002852YDR444WUncharacterizedHypothetical protein 4e-050.00109 S000005905YOR378WUncharacterizedHypothetical protein 4e-050.00109 S000004551ALO1YML086CverifiedD-Arabinono-1,4-lactone oxidase, catalyzes the final step inbiosynthesis of D-erythroascorbic acid, whichis protective against oxidative stress 4e-050.00109 S000028698YNL024C-AUncharacterizedPutative protein of unknown function; YNL024C-A is an essential gene 4e-050.00109 S000005450MSH2YOL090WverifiedProtein that forms heterodimers with Msh3p and Msh6p that bindto DNA mismatches to initiate the mismatchrepair process; contains a Walker ATP-bindingmotif required for repair activity; Msh2p-Msh6pbinds to and hydrolyzes ATP 4e-050.00109 S000001285YKE4YIL023CverifiedZinc transporter; localizes to the ER; null mutant is sensitiveto calcofluor white, leads to zinc accumulationin cytosol; ortholog of the mouse KE4 andmember of the ZIP (ZRT, IRT-like Protein)family 4e-050.00109 S000000622RHB1YCR027CverifiedPutative Rheb-related GTPase involved in regulating canavanineresistance and arginine uptake; member of theRas superfamily of G-proteins 4e-050.00109 S000003717YJL181WUncharacterizedHypothetical protein 4e-050.00109 S000005806FSH3YOR280CverifiedSerine hydrolase; sequence is similar to Fsh1p and Fsh2p 4e-050.00109 S000001802RPL40BYKR094CverifiedFusion protein, identical to Rpl40Ap, that is cleaved to yieldubiquitin and a ribosomal protein of the large(60S) ribosomal subunit with similarity to ratL40; ubiquitin may facilitate assembly of theribosomal protein into ribosomes 4e-050.00109 S000001776BET3YKR068CverifiedHydrophilic protein that acts in conjunction with SNAREproteins in targeting and fusion of ER to Golgitransport vesicles; component of the TRAPP(transport protein particle) complex 4e-050.00109 S000007611YJL062W-AUncharacterizedPutative protein of unknown function, identified based on comparison to related yeast species; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria 4e-050.00109 S000003944SPA2YLL021WverifiedComponent of the polarisome, which functions in actincytoskeletal organization during polarizedgrowth; acts as a scaffold for Mkk1p and Mpk1pcell wall integrity signaling components;potential Cdc28p substrate 4e-050.00109 S000003971YBT1YLL048CverifiedTransporter of the ATP-binding cassette (ABC) family involvedin bile acid transport; similar to mammalianbile transporters 4e-050.00109 S000005154MER1YNL210WverifiedProtein with RNA-binding motifs required for meiosis-specificmRNA splicing; required for chromosome pairingand meiotic recombination 4e-050.00109 S000001687EAP1YKL204WverifiedeIF4E-associated protein, binds eIF4E and inhibitscap-dependent translation, also functionsindependently of eIF4E to maintain geneticstability; plays a role in cell growth,implicated in the TOR signaling cascade 4e-050.00109 S000005918HSP33YOR391CuncharacterizedPossible chaperone and cysteine protease with similarity to E.coli Hsp31 and S. cerevisiae Hsp32p, Hsp33p,and Sno4p; member of the DJ-1/ThiJ/PfpIsuperfamily, which includes human DJ-1 involvedin Parkinson's disease 4e-050.00109 S000004935DIA1YMR316WverifiedProtein of unknown function, involved in invasive andpseudohyphal growth; green fluorescent protein(GFP)-fusion protein localizes to the cytoplasmin a punctate pattern 4e-050.00109 S000001588YKL105CUncharacterizedPutative protein of unknown function 4e-050.00109 S000001791DAD2YKR083CverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; is transferred to thekinetochore prior to mitosis 4e-050.00109 S000005251MCK1YNL307CverifiedProtein serine/threonine/tyrosine (dual-specificity) kinaseinvolved in control of chromosome segregationand in regulating entry into meiosis; relatedto mammalian glycogen synthase kinases of theGSK-3 family 4e-050.00109 S000002359MGT1YDL200CverifiedDNA repair methyltransferase (6-O-methylguanine-DNA methylase)involved in protection against DNA alkylationdamage 4e-050.00109 S000003518BIO2YGR286CverifiedBiotin synthase, catalyzes the conversion of dethiobiotin tobiotin, which is the last step of the biotinbiosynthesis pathway; complements E. coli bioBmutant 4e-050.00109 S000001858RPO41YFL036WverifiedMitochondrial RNA polymerase; single subunit enzyme similar tothose of T3 and T7 bacteriophages; requires aspecificity subunit encoded by MTF1 forpromoter recognition 4e-050.00109 S000006392MLC2YPR188CuncharacterizedRegulatory light chain for the type II myosin, Myo1p; binds toan IQ motif of Myo1p, localization to the budneck depends on Myo1p; involved in thedisassembly of the Myo1p ring 4e-050.00109 S000003966FPS1YLL043WverifiedPlasma membrane glycerol channel, member of the major intrinsicprotein (MIP) family of channel proteins;involved in efflux of glycerol and in uptake ofthe trivalent metalloids arsenite andantimonite 4e-050.00109 S000005797FSF1YOR271C</