Yfunc lets you browse current and predicted gene functions in yeast

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Prediction of GO:0016407 "acetyltransferase activity"

GO branch: MF
Number of currently annotated genes: 50

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest Lum:NevirapineTAP:74Lum:EfavirenzLum:PhenylbutazoneLum:ThalidomideLum:SulfinpyrazoneLum:MolsidomineLum:NifedipineLum:ProcaineLum:Carbendazim S000006255MAK3YPR051WverifiedCatalytic subunit of N-terminal acetyltransferase of the NatCtype; required for replication of dsRNA virus &radic0.680790.98165 S000003484GCN5YGR252WverifiedHistone acetyltransferase, acetylates N-terminal lysines onhistones H2B and H3; catalytic subunit of theADA and SAGA histone acetyltransferasecomplexes; founding member of the Gcn5p-relatedN-acetyltransferase superfamily &radic0.682840.98165 S000006007ELP3YPL086CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;exhibits histone acetyltransferase activitythat is directed to histones H3 and H4;disruption confers resistance to K. lactiszymotoxin &radic0.69190.98165&radic&radic&radic&radic&radic&radic&radic&radic S000001055ARD1YHR013CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing &radic0.707530.98165&radic&radic&radic&radic&radic S000005779NAT5YOR253WverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing &radic0.673840.9752&radic&radic&radic&radic&radic&radic&radic S000006335NAT3YPR131CverifiedCatalytic subunit of the NatB N-terminal acetyltransferase,which catalyzes acetylation of theamino-terminal methionine residues of allproteins beginning with Met-Asp or Met-Glu andof some proteins beginning with Met-Asn orMet-Met &radic0.661720.95823&radic&radic S000005770ESA1YOR244WverifiedHistone acetyltransferase catalytic subunit of the nativemultisubunit complex (NuA4) that acetylatesfour conserved internal lysines of histone H4N-terminal tail; required for cell cycleprogression &radic0.52620.95312&radic&radic&radic&radic&radic&radic S000002478PAA1YDR071CverifiedPolyamine acetyltransferase; acetylates polyamines (e.g.putrescine, spermidine, spermine) and alsoaralkylamines (e.g. tryptamine,phenylethylamine); may be involved intranscription and/or DNA replication &radic0.50670.95141 S000001481YIR042CUncharacterizedPutative protein of unknown function; YIR042C is a non-essential gene 0.491040.94493&radic&radic&radic&radic&radic&radic S000005922HAT1YPL001WverifiedCatalytic subunit of the Hat1p-Hat2p histone acetyltransferasecomplex that uses the cofactor acetyl coenzymeA, to acetylate free nuclear and cytoplasmichistone H4; involved in telomeric silencing andDNA double-strand break repair &radic0.429790.93469&radic&radic&radic&radic S000003663SPT10YJL127CverifiedPutative histone acetylase, sequence-specific activator ofhistone genes, binds specifically and highlycooperatively to pairs of UAS elements in corehistone promoters, functions at or near theTATA box &radic0.405220.93469 S000001855ACT1YFL039CverifiedActin, structural protein involved in cell polarization,endocytosis, and other cytoskeletal functions 0.414890.93469&radic&radic&radic&radic&radic&radic&radic S000000792HPA3YEL066WverifiedD-Amino acid N-acetyltransferase, catalyzes N-acetylation ofD-amino acids through ordered bi-bi mechanismin which acetyl-CoA is first substrate boundand CoA is last product liberated; similar toHpa2p, acetylates histones weakly in vitro &radic0.43790.93469&radic&radic&radic&radic S000001877GNA1YFL017CverifiedEvolutionarily conserved glucosamine-6-phosphateacetyltransferase required for multiple cellcycle events including passage through START,DNA synthesis, and mitosis; involved inUDP-N-acetylglucosamine synthesis, formsGlcNAc6P from AcCoA &radic0.384810.93376&radic&radic&radic&radic&radic&radic S000006397HPA2YPR193CverifiedTetrameric histone acetyltransferase with similarity to Gcn5p,Hat1p, Elp3p, and Hpa3p; acetylates histones H3and H4 in vitro and exhibits autoacetylationactivity &radic0.369150.93055&radic&radic&radic&radic&radic&radic S000004673NAT4YMR069WverifiedN alpha-acetyl-transferase, involved in acetylation of theN-terminal residues of histones H4 and H2A &radic0.36720.92973 S000006050TAF14YPL129WverifiedSubunit (30 kDa) of TFIID, TFIIF, and SWI/SNF complexes,involved in RNA polymerase II transcriptioninitiation and in chromatin modification,contains a YEATS domain 0.341460.91709&radic&radic&radic S000005051YAF9YNL107WverifiedSubunit of both the NuA4 histone H4 acetyltransferase complexand the SWR1 complex, may function toantagonize silencing near telomeres; interactsdirectly with Swc4p, has homology to humanleukemogenic protein AF9, contains a YEATSdomain 0.322030.90476&radic S000004734SAS2YMR127CverifiedHistone acetyltransferase (HAT) catalytic subunit of the SAScomplex (Sas2p-Sas4p-Sas5p), which acetylatesfree histones and nucleosomes and regulatestranscriptional silencing; member of theMYSTacetyltransferase family &radic0.310630.89895 S000000779MAK10YEL053CverifiedNon-catalytic subunit of N-terminal acetyltransferase of theNatC type, required for replication of dsRNAvirus; expression is glucose-repressible &radic0.302040.89373&radic&radic&radic&radic&radic S000003409ATF2YGR177CverifiedAlcohol acetyltransferase, may play a role in steroiddetoxification; forms volatile esters duringfermentation, which is important in brewing &radic0.268860.88238&radic&radic&radic&radic&radic&radic S000000148SAS3YBL052CverifiedHistone acetyltransferase catalytic subunit of NuA3 complexthat acetylates histone H3, involved intranscriptional silencing; homolog of themammalian MOZ proto-oncogene; sas3 gcn5 doublemutation confers lethality &radic0.265560.87985&radic&radic&radic&radic&radic&radic S000005904ATF1YOR377WverifiedAlcohol acetyltransferase with potential roles in lipid andsterol metabolism; responsible for the majorpart of volatile acetate ester productionduring fermentation &radic0.245810.8673&radic&radic&radic&radic&radic&radic&radic S000000744EAF5YEL018WuncharacterizedEsa1p-associated factor, subunit of the NuA4 acetyltransferasecomplex 0.226170.85273&radic&radic&radic&radic&radic&radic S000004975HHF2YNL030WverifiedOne of two identical histone H4 proteins (see also HHF1); corehistone required for chromatin assembly andchromosome function; contributes to telomericsilencing; N-terminal domain involved inmaintaining genomic integrity 0.210420.83694&radic S000000826YAT2YER024WverifiedCarnitine acetyltransferase; has similarity to Yat1p, which isa carnitine acetyltransferase associated withthe mitochondrial outer membrane &radic0.207560.83454&radic&radic&radic&radic&radic&radic&radic&radic&radic S000000080YAT1YAR035WverifiedOuter mitochondrial carnitine acetyltransferase, minorethanol-inducible enzyme involved in transportof activated acyl groups from the cytoplasminto the mitochondrial matrix &radic0.201680.8295&radic&radic&radic&radic&radic&radic&radic&radic S000004506CAT2YML042WverifiedCarnitine acetyl-CoA transferase present in both mitochondriaand peroxisomes, transfers activated acetylgroups to carnitine to form acetylcarnitinewhich can be shuttled across membranes &radic0.20150.82892 S000002767VID21YDR359CverifiedComponent of the NuA4 histone acetyltransferase complex 0.187330.81161&radic&radic&radic&radic S000004823YMR210WVerifiedPutative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification 0.17340.79601&radic&radic&radic&radic S000003617ARP4YJL081CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes &radic0.168740.79303&radic S000000614MAK31YCR020C-AverifiedNon-catalytic subunit of N-terminal acetyltransferase of theNatC type; required for replication of dsRNAvirus; member of the Sm protein family &radic0.16480.78663&radic&radic&radic&radic&radic&radic S000001870EPL1YFL024CverifiedComponent of NuA4, which is an essential histone H4/H2Aacetyltransferase complex; homologous toDrosophila Enhancer of Polycomb &radic0.156710.77745&radic&radic&radic&radic&radic&radic&radic&radic S000004466YAP1YML007WverifiedBasic leucine zipper (bZIP) transcription factor required foroxidative stress tolerance; mediatespleiotropic drug and metal resistance;localized to the nucleus in response to thepresence of oxidants 0.14890.76533&radic&radic&radic&radic&radic&radic&radic S000006227EAF3YPR023CverifiedEsa1p-associated factor, nonessential component of the NuA4acetyltransferase complex, homologous toDrosophila dosage compensation protein MSL3 &radic0.138520.7506&radic S000001422POT1YIL160Cverified3-ketoacyl-CoA thiolase with broad chain length specificity,cleaves 3-ketoacyl-CoA into acyl-CoA andacetyl-CoA during beta-oxidation of fatty acids 0.125610.729 S000001141TRA1YHR099WverifiedSubunit of SAGA and NuA4 histone acetyltransferase complexes;interacts with acidic activators (e.g., Gal4p)which leads to transcription activation;similar to human TRRAP, which is a cofactor forc-Myc mediated oncogenic transformation &radic0.124120.72597&radic S000003432ELP2YGR200CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;target of Kluyveromyces lactis zymocin 0.113110.70473&radic&radic&radic S000005446ADH1YOL086CverifiedAlcohol dehydrogenase, fermentative isozyme active as homo- orheterotetramers; required for the reduction ofacetaldehyde to ethanol, the last step in theglycolytic pathway 0.108840.69863&radic S000006022ELP4YPL101WverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;required for Elongator structural integrity 0.101290.68493 S000000402TAF5YBR198CverifiedSubunit (90 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification 0.098870.67973&radic&radic&radic&radic S000002213PSA1YDL055CverifiedGDP-mannose pyrophosphorylase (mannose-1-phosphateguanyltransferase), synthesizes GDP-mannosefrom GTP and mannose-1-phosphate in cell wallbiosynthesis; required for normal cell wallstructure 0.09590.67402 S000001230IKI1YHR187WverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;iki1 mutations confer resistance to the K.lactis toxin zymocin 0.093940.66793 S000006016EEB1YPL095CverifiedAcyl-coenzymeA:ethanol O-acyltransferase responsible for themajor part of medium-chain fatty acid ethylester biosynthesis during fermentation;possesses short chain esterase activity; may beinvolved in lipid metabolism and detoxification &radic0.092880.66682&radic&radic&radic&radic&radic&radic S000000966CHD1YER164WverifiedNucleosome remodeling factor that functions in regulation oftranscription elongation; contains a chromodomain, a helicase domain and a DNA-bindingdomain; component of both the SAGA and SILKcomplexes 0.087920.65037 S000000381EHT1YBR177CverifiedAcyl-coenzymeA:ethanol O-acyltransferase that plays a minorrole in medium-chain fatty acid ethyl esterbiosynthesis; contains esterase activity;localizes to lipid particles and themitochondrial outer membrane &radic0.082520.6347&radic&radic&radic&radic&radic S000002555KGD2YDR148CverifiedDihydrolipoyl transsuccinylase, a component of themitochondrial alpha-ketoglutarate dehydrogenasecomplex, which catalyzes a step in thetricarboxylic acid (TCA) cycle, the oxidativedecarboxylation of alpha-ketoglutarate tosuccinyl-CoA 0.079770.6284&radic&radic S000000871ARG5,6YER069WverifiedProtein that is processed in the mitochondrion to yieldacetylglutamate kinase andN-acetyl-gamma-glutamyl-phosphate reductase,which catalyze the 2nd and 3rd steps inarginine biosynthesis; enzymes form a complexwith Arg2p 0.079630.62726&radic&radic&radic S000002583NGG1YDR176WverifiedTranscriptional regulator involved in glucose repression ofGal4p-regulated genes; component oftranscriptional adaptor and histoneacetyltransferase complexes, the ADA complex,the SAGA complex, and the SLIK complex 0.074810.61027&radic&radic&radic&radic&radic&radic S000001686TOR2YKL203CverifiedPIK-related protein kinase and rapamycin target; subunit ofTORC1, a complex that regulates growth inresponse to nutrients and TORC2, a complex thatregulates cell-cycle dependent polarization ofthe actin cytoskeleton; involved in meiosis 0.073450.60628&radic&radic&radic&radic&radic S000002619GCD6YDR211WverifiedCatalytic epsilon subunit of the translation initiation factoreIF2B, the guanine-nucleotide exchange factorfor eIF2; activity subsequently regulated byphosphorylated eIF2; first identified as anegative regulator of GCN4 expression 0.071510.59629&radic&radic&radic&radic&radic&radic S000006152FAS2YPL231WverifiedAlpha subunit of fatty acid synthetase, which catalyzes thesynthesis of long-chain saturated fatty acids;contains beta-ketoacyl reductase andbeta-ketoacyl synthase activities 0.066180.57995&radic&radic&radic&radic S000002574TAF10YDR167WverifiedSubunit (145 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification 0.065550.57802&radic&radic&radic&radic S000005786GCD1YOR260WverifiedGamma subunit of the translation initiation factor eIF2B, theguanine-nucleotide exchange factor for eIF2;activity subsequently regulated byphosphorylated eIF2; first identified as anegative regulator of GCN4 expression 0.063510.56872&radic&radic&radic&radic&radic&radic&radic S000004722ASC1YMR116CverifiedWD repeat protein (G-beta like protein) involved in translationregulation; required for repression of Gcn4pactivity in the absence of amino-acidstarvation; core component of the ribosome;ortholog of mammalian RACK1 0.062250.56404 S000002552TAF12YDR145WverifiedSubunit (61/68 kDa) of TFIID and SAGA complexes, involved inRNA polymerase II transcription initiation andin chromatin modification, similar to histoneH2A 0.061430.56176&radic&radic&radic&radic&radic S000003486ENO1YGR254WverifiedEnolase I, a phosphopyruvate hydratase that catalyzes theconversion of 2-phosphoglycerate tophosphoenolpyruvate during glycolysis and thereverse reaction during gluconeogenesis;expression is repressed in response to glucose 0.058790.55146 S000004840TAF7YMR227CverifiedTFIID subunit (67 kDa), involved in RNA polymerase IItranscription initiation 0.056440.5407&radic&radic&radic&radic&radic S000003322UTP22YGR090WuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.054990.53532&radic&radic&radic&radic S000000288MIS1YBR084WverifiedMitochondrial C1-tetrahydrofolate synthase, involved ininterconversion between different oxidationstates of tetrahydrofolate (THF); providesactivities of formyl-THF synthetase,methenyl-THF cyclohydrolase, and methylene-THFdehydrogenase 0.054030.52912 S000003425PDX1YGR193CverifiedDihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) ofthe mitochondrial pyruvate dehydrogenase (PDH)complex, plays a structural role in the complexby binding and positioning E3 to thedihydrolipoamide acetyltransferase (E2) core 0.05120.51611&radic&radic&radic S000003827TOR1YJR066WverifiedPIK-related protein kinase and rapamycin target; subunit ofTORC1, a complex that controls growth inresponse to nutrients by regulatingtranslation, transcription, ribosomebiogenesis, nutrient transport and autophagy;involved in meiosis 0.049030.50339&radic&radic&radic&radic S000003910YJR149WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.048580.50024 S000001065MYO1YHR023WverifiedType II myosin heavy chain, required for wild-type cytokinesisand cell separation; localizes to theactomyosin ring; binds to myosin light chainsMlc1p and Mlc2p through its IQ1 and IQ2 motifsrespectively 0.047180.49517 S000004849TAF9YMR236WverifiedSubunit (17 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification, similar to histone H3 0.047090.49479&radic&radic&radic&radic S000004045SPT8YLR055CverifiedSubunit of the SAGA transcriptional regulatory complex but notpresent in SAGA-like complex SLIK/SALSA,required for SAGA-mediated inhibition at somepromoters 0.045260.48813&radic&radic&radic&radic&radic S000000340MEC1YBR136WverifiedGenome integrity checkpoint protein and PI kinase superfamilymember; signal transducer required for cellcycle arrest and transcriptional responsesprompted by damaged or unreplicated DNA;monitors and participates in meioticrecombination 0.039760.4651 S000001717FOX2YKR009CverifiedMultifunctional enzyme of the peroxisomal fatty acidbeta-oxidation pathway; has 3-hydroxyacyl-CoAdehydrogenase and enoyl-CoA hydrataseactivities 0.039580.46424&radic&radic&radic&radic&radic S000003712SWI3YJL176CverifiedSubunit of the SWI/SNF chromatin remodeling complex, whichregulates transcription by remodelingchromosomes; required for transcription of manygenes, including ADH1, ADH2, GAL1, HO, INO1 andSUC2 0.038840.46106&radic&radic&radic&radic&radic&radic S000004391BDF1YLR399CverifiedProtein involved in transcription initiation at TATA-containingpromoters; associates with the basaltranscription factor TFIID; contains twobromodomains; corresponds to the C-terminalregion of mammalian TAF1; redundant with Bdf2p 0.037280.45377&radic&radic&radic&radic&radic&radic S000006147NEW1YPL226WverifiedATP binding cassette family member; Asn/Gln-rich rich regionsupports [NU+] prion formation, susceptibilityto [PSI+] prion induction and aggregation of afragment of the human Machado-Joseph Diseaseprotein 0.036670.45106&radic&radic&radic S000000316CYC8YBR112CverifiedGeneral transcriptional co-repressor, acts together with Tup1p;also acts as part of a transcriptionalco-activator complex that recruits the SWI/SNFand SAGA complexes to promoters 0.035590.44556 S000003234SWC4YGR002CverifiedProtein of unknown function, component of the Swr1p complexthat incorporates Htz1p into chromatin;component of the NuA4 histone acetyltransferasecomplex 0.035280.44363&radic&radic&radic&radic S000001046NEM1YHR004CverifiedProtein of the nuclear envelope required for the sphericalshape of the nucleus; required for normalsporulation 0.03210.42879 S000004376IKI3YLR384CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;maintains structural integrity of Elongator;homolog of human IKAP, mutations in which causefamilial dysautonomia (FD) &radic0.029320.41409&radic&radic&radic&radic&radic S000004334FKS1YLR342WverifiedCatalytic subunit of 1,3-beta-D-glucan synthase, functionallyredundant with alternate catalytic subunitGsc2p; binds to regulatory subunit Rho1p;involved in cell wall synthesis andmaintenance; localizes to sites of cell wallremodeling 0.028690.40929&radic&radic&radic&radic S000000007SPO7YAL009WverifiedIntegral nuclear/ER membrane protein of unknown function,required for normal nuclear envelope morphologyand sporulation 0.028150.40479&radic&radic&radic&radic&radic&radic S000004836UBP8YMR223WverifiedUbiquitin-specific protease that is a component of the SAGA(Spt-Ada-Gcn5-Acetyltransferase) acetylationcomplex; required for SAGA-mediateddeubiquitination of histone H2B 0.027340.40137&radic&radic S000005932TAF3YPL011CverifiedTFIID subunit (47 kDa), involved in promoter binding and RNApolymerase II transcription initiation 0.027040.39766&radic S000005550IRC12YOR024WdubiousHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 0.025140.38461&radic&radic&radic S000004312MMS22YLR320WverifiedProtein involved in resistance to ionizing radiation; acts withMms1p in a repair pathway that may be involvedin resolving replication intermediates orpreventing the damage caused by blockedreplication forks 0.024690.37639&radic&radic&radic&radic&radic&radic S000004614CLU1YMR012WverifiedeIF3 component of unknown function; deletion causes defects inmitochondrial organization but not in growth ortranslation initiation, can rescue cytokinesisand mitochondrial organization defects of theDictyostelium cluA- mutant 0.024740.37639&radic&radic&radic&radic S000003080TAF6YGL112CverifiedSubunit (60 kDa) of TFIID and SAGA complexes, involved intranscription initiation of RNA polymerase IIand in chromatin modification, similar tohistone H4 0.023950.37521 S000000285SPT7YBR081CverifiedSubunit of the SAGA transcriptional regulatory complex,involved in proper assembly of the complex;also present as a C-terminally truncated formin the SLIK/SALSA transcriptional regulatorycomplex 0.023690.37027 S000000183RPL23AYBL087CverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl23Bp and has similarity to E.coli L14 and rat L23 ribosomal proteins 0.023280.36967&radic&radic&radic&radic&radic&radic&radic S000000125YBL029WUncharacterizedHypothetical protein 0.022890.36719&radic&radic&radic&radic&radic S000006175HFI1YPL254WverifiedAdaptor protein required for structural integrity of the SAGAcomplex, a histoneacetyltransferase-coactivator complex that isinvolved in global regulation of geneexpression through acetylation andtranscription functions 0.02280.36661&radic&radic&radic&radic&radic S000001132YNG2YHR090CverifiedSubunit of the NuA4 histone acetyltransferase complex thatacetylates histone H4 and H2A; has similarityto the human tumor suppressor ING1 0.022660.36439 S000003038RPB9YGL070CverifiedRNA polymerase II subunit B12.6; contacts DNA; mutations affecttranscription start site; involved in telomeremaintenance 0.022450.36373&radic&radic&radic&radic S000004477TAF11YML015CverifiedTFIID subunit (40 kDa), involved in RNA polymerase IItranscription initiation, similar to histone H3with atypical histone fold motif of Spt3-liketranscription factors 0.022460.36373 S000000184TEL1YBL088CverifiedProtein kinase primarily involved in telomere lengthregulation; contributes to cell cyclecheckpoint control in response to DNA damage;functionally redundant with Mec1p; homolog ofhuman ataxia telangiectasia (ATM) gene 0.022130.36111&radic&radic&radic&radic S000000656TAH1YCR060WverifiedHSP90 cofactor; interacts with Hsp82p, Pih1p, Rvb1 and Rvb2,contains a single TPR domain with at least twoTPR motifs 0.020840.35061 S000001526PHD1YKL043WverifiedTranscriptional activator that enhances pseudohyphal growth;regulates expression of FLO11, an adhesinrequired for pseudohyphal filament formation;similar to StuA, an A. nidulans developmentalregulator; potential Cdc28p substrate 0.020540.34643&radic&radic&radic&radic&radic&radic S000000449ISW1YBR245CverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPase thatforms a complex with Ioc2p and Ioc4p toregulate transcription elongation, and acomplex with Ioc3p to repress transcriptioninitiation 0.020120.34365&radic&radic&radic&radic&radic S000000885GET2YER083CverifiedSubunit of the GET complex; required for meiotic nucleardivision and for the retrieval of HDEL proteinsfrom the Golgi to the ER in an ERD2 dependentfashion; may be involved in cell wall function 0.019630.34047&radic&radic&radic&radic&radic S000003848YJR088CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum 0.019480.33852 S000002840NPL3YDR432WverifiedRNA-binding protein that carries poly(A)+ mRNA from the nucleusinto the cytoplasm; phosphorylation by Sky1p inthe cytoplasm may promote release of mRNAs 0.01940.33852&radic&radic&radic&radic&radic S000003945HIF1YLL022CverifiedNon-essential component of the HAT-B histone acetyltransferasecomplex (Hat1p-Hat2p-Hif1p), localized to thenucleus; has a role in telomeric silencing 0.019270.33745 S000001587GFA1YKL104CverifiedGlutamine-fructose-6-phosphate amidotransferase, catalyzes theformation of glucosamine-6-P and glutamate fromfructose-6-P and glutamine in the first step ofchitin biosynthesis 0.019180.33646&radic&radic&radic&radic&radic S000004197HRD3YLR207WverifiedResident protein of the ER membrane that plays a central rolein ER-associated protein degradation (ERAD),forms HRD complex with Hrd1p and ERADdeterminants that engages in lumen to cytosolcommunication and coordination of ERAD events 0.018980.3342&radic&radic&radic&radic&radic&radic S000005677RPB2YOR151CverifiedRNA polymerase II second largest subunit B150, part of centralcore; similar to bacterial beta subunit 0.018880.334&radic&radic&radic&radic&radic S000004620YMR018WUncharacterizedPutative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene 0.018420.32984&radic&radic&radic S000000329PTC4YBR125CverifiedCytoplasmic type 2C protein phosphatase; identified as ahigh-copy number suppressor of the syntheticlethality of a cnb1 mpk1 double deletion;overexpression decreases high-osmolarityinduced Hog1p phosphorylation and kinaseactivity 0.018590.32984 S000002856ADA2YDR448WverifiedTranscription coactivator, component of the ADA and SAGAtranscriptional adaptor/HAT (histoneacetyltransferase) complexes 0.017940.32607 S000005533SGT2YOR007CverifiedGlutamine-rich cytoplasmic protein of unknown function;contains tetratricopeptide (TPR) repeats, whichoften mediate protein-protein interactions; hassimilarity to human SGT, which is a cochaperonethat negatively regulates Hsp70 0.017840.32346&radic&radic&radic&radic&radic S000004470SPT5YML010WverifiedProtein that forms a complex with Spt4p and mediates bothactivation and inhibition of transcriptionelongation; Spt4p-Spt5p complex also plays arole in pre-mRNA processing 0.017840.32346&radic&radic&radic&radic&radic&radic S000001505CDC16YKL022CverifiedSubunit of the anaphase-promoting complex/cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition; required forsporulation 0.017640.32346&radic&radic&radic&radic&radic&radic S000000566MRC1YCL061CverifiedS-phase checkpoint protein found at replication forks, requiredfor DNA replication; also required for Rad53pactivation during DNA replication stress, whereit forms a replication-pausing complex withTof1p and is phosphorylated by Mec1p; proteininvolved in replication checkpoint 0.017360.32076&radic&radic&radic&radic&radic&radic&radic S000005643RPT5YOR117WverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; recruited to theGAL1-10 promoter region upon induction oftranscription 0.017290.31766&radic&radic&radic S000005722LIP5YOR196CverifiedProtein involved in biosynthesis of the coenzyme lipoic acid,has similarity to E. coli lipoic acid synthase 0.01690.31627&radic S000000015PSK1YAL017WverifiedOne of two (see also PSK2) PAS domain containing S/T proteinkinases; coordinately regulates proteinsynthesis and carbohydrate metabolism andstorage in response to a unknown metabolitethat reflects nutritional status 0.016820.31616&radic&radic&radic S000003355PPT1YGR123CverifiedProtein serine/threonine phosphatase with similarity to humanphosphatase PP5; present in both the nucleusand cytoplasm; expressed during logarithmicgrowth 0.016790.31427&radic&radic S000001338SEC28YIL076WverifiedEpsilon-COP subunit of the coatomer; regulates retrogradeGolgi-to-ER protein traffic; stabilizes Cop1p,the alpha-COP and the coatomer complex;non-essential for cell growth 0.016590.31383&radic&radic&radic&radic&radic&radic S000006156RVB2YPL235WverifiedEssential protein involved in transcription regulation;component of chromatin remodeling complexes;required for assembly and function of the INO80complex; member of the RUVB-like protein family 0.016540.31278&radic&radic&radic&radic&radic S000002977LEU1YGL009CverifiedIsopropylmalate isomerase, catalyzes the second step in theleucine biosynthesis pathway 0.016350.31161&radic&radic&radic&radic&radic&radic S000005180SIN4YNL236WverifiedSubunit of the Mediator complex; interacts with the RNApolymerase II holoenzyme to postively ornegatively regulate transcription; dispensiblefor basal transcription 0.016430.31161&radic&radic&radic&radic&radic&radic&radic&radic S000003957RIX7YLL034CverifiedPutative ATPase of the AAA family, required for export ofpre-ribosomal large subunits from the nucleus;distributed between the nucleolus, nucleoplasm,and nuclear periphery depending on growthconditions 0.016190.30861&radic&radic&radic S000001542MPE1YKL059CverifiedEssential conserved subunit of CPF (cleavage andpolyadenylation factor), plays a role in 3' endformation of mRNA via the specific cleavage andpolyadenylation of pre-mRNA, contains aputative RNA-binding zinc knuckle motif 0.016020.30763&radic&radic&radic&radic&radic&radic&radic S000002299RPO21YDL140CverifiedRNA polymerase II largest subunit B220, part of central core;phosphorylation of C-terminal heptapeptiderepeat domain regulates association withtranscription and splicing factors; similar tobacterial beta-prime 0.016070.30763 S000006311YTH1YPR107CverifiedEssential RNA-binding component of cleavage and polyadenylationfactor, contains five zinc fingers; requiredfor pre-mRNA 3'-end processing andpolyadenylation 0.016020.30763&radic&radic&radic&radic S000005372HTZ1YOL012CverifiedHistone variant H2AZ, exchanged for histone H2A in nucleosomesby the SWR1 complex; involved intranscriptional regulation through preventionof the spread of silent heterochromatin 0.016050.30763&radic&radic&radic&radic&radic&radic&radic S000002187ARP2YDL029WverifiedEssential component of the Arp2/3 complex, which is a highlyconserved actin nucleation center required forthe motility and integrity of actin patches;involved in endocytosis and membrane growth andpolarity 0.015810.30353 S000003964SDH2YLL041CverifiedIron-sulfur protein subunit of succinate dehydrogenase (Sdh1p,Sdh2p, Sdh3p, Sdh4p), which couples theoxidation of succinate to the transfer ofelectrons to ubiquinone 0.015830.30353&radic&radic&radic&radic&radic&radic S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling 0.015530.30226&radic&radic S000006128TYW1YPL207WuncharacterizedHypothetical protein 0.015620.30226&radic&radic&radic&radic&radic&radic&radic S000001622CTK1YKL139WverifiedCatalytic (alpha) subunit of C-terminal domain kinase I(CTDK-I), which phosphorylates the C-terminalrepeated domain of the RNA polymerase II largesubunit (Rpo21p) to affect both transcriptionand pre-mRNA 3' end processing 0.015490.3002&radic&radic&radic&radic S000000180CDC27YBL084CverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 0.014990.29625&radic&radic&radic S000005715IES4YOR189WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.014870.29539&radic&radic&radic&radic&radic S000005217TOF1YNL273WverifiedSubunit of a replication-pausing checkpoint complex(Tof1p-Mrc1p-Csm3p) that acts at the stalledreplication fork to promote sister chromatidcohesion after DNA damage, facilitating gaprepair of damaged DNA; interacts with the MCMhelicase 0.014850.29539&radic&radic&radic&radic&radic S000000123RPL19BYBL027WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl19Ap and has similarity to ratL19 ribosomal protein; rpl19a and rpl19b singlenull mutations result in slow growth, while thedouble null mutation is lethal 0.01480.29468&radic&radic&radic&radic S000000081SWH1YAR042WverifiedProtein similar to mammalian oxysterol-binding protein;contains ankyrin repeats; localizes to theGolgi and the nucleus-vacuole junction 0.014770.29441&radic&radic&radic&radic S000004012SDO1YLR022CuncharacterizedEssential protein involved in RNA metabolism, one of two yeasthomologs (with Yhr087wp) of the human proteinSBDS responsible for autosomal recessiveShwachman-Bodian-Diamond Syndrome, alsoconserved in Archaea 0.014720.29261&radic&radic&radic&radic&radic&radic&radic S000003034SGF73YGL066Wverified73 kDa subunit of SAGA histone acetyltransferase complex;involved in formation of the preinitiationcomplex assembly at promoters &radic0.01460.28925&radic&radic&radic&radic S000001887BLM10YFL007WverifiedProteosome activator subunit; found in association with coreparticles, with and without the 19S regulatoryparticle; required for resistance to bleomycin,may be involved in protecting against oxidativedamage; similar to mammalian PA200 0.014530.28925&radic&radic&radic&radic&radic&radic&radic&radic S000004225YLR235CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TOP3 0.014060.28635&radic&radic&radic&radic&radic&radic&radic S000002495SLU7YDR088CverifiedRNA splicing factor, required for ATP-independent portion of2nd catalytic step of spliceosomal RNAsplicing; interacts with Prp18p; contains zincknuckle domain 0.014040.28601&radic&radic&radic&radic&radic&radic S000000516SGF29YCL010CverifiedSaGa associated Factor 29kDa; Probable 29kKDa Subunit of SAGAhistone acetyltransferase complex 0.014030.28601&radic&radic&radic&radic&radic S000000104HIR1YBL008WverifiedNon-essential transcriptional corepressor involved in the cellcycle-regulated transcription of histone H2A,H2B, H3 and H4 genes; contributes to nucleosomeformation, heterochromatic gene silencing, andformation of functional kinetochores 0.013920.28429&radic&radic&radic&radic&radic&radic S000001145SBE22YHR103WverifiedProtein involved in the transport of cell wall components fromthe Golgi to the cell surface; similar instructure and functionally redundant withSbe2p; involved in bud growth 0.013880.28429&radic&radic&radic&radic&radic S000004106MSL5YLR116WverifiedComponent of the commitment complex, which defines the firststep in the splicing pathway; essential proteinthat interacts with Mud2p and Prp40p, forming abridge between the intron ends; also involvedin nuclear retention of pre-mRNA 0.013960.28429&radic&radic&radic&radic&radic&radic S000004897YKU70YMR284WverifiedSubunit of the telomeric Ku complex (Yku70p-Yku80p), involvedin telomere length maintenance, structure andtelomere position effect; relocates to sites ofdouble-strand cleavage to promote nonhomologousend joining during DSB repair 0.013860.28407&radic&radic&radic&radic S000005162MGS1YNL218WverifiedProtein with DNA-dependent ATPase and ssDNA annealingactivities involved in maintenance of genome;interacts functionally with DNA polymerasedelta; homolog of human Werner helicaseinteracting protein (WHIP) 0.013660.28107&radic&radic&radic&radic&radic S000004873TIF11YMR260CverifiedTranslation initiation factor eIF1A, essential protein thatforms a complex with Sui1p (eIF1) and the 40Sribosomal subunit and scans for the startcodon; C-terminus associates with Fun12p(eIF5B); N terminus interacts with eIF2 andeIF3 0.013550.27697&radic&radic&radic S000000033FUN12YAL035WverifiedGTPase, required for general translation initiation bypromoting Met-tRNAiMet binding to ribosomes andribosomal subunit joining; homolog of bacterialIF2 0.013290.27697&radic&radic&radic&radic S000005549AHC1YOR023CverifiedSubunit of the Ada histone acetyltransferase complex, requiredfor structural integrity of the complex &radic0.013070.27482&radic&radic&radic&radic&radic&radic&radic S000001593KTI12YKL110CverifiedProtein that plays a role, with Elongator complex, inmodification of wobble nucleosides in tRNA;involved in sensitivity to G1 arrest induced byzymocin; interacts with chromatin throughoutthe genome; also interacts with Cdc19p 0.013040.27397&radic&radic&radic&radic&radic S000006102CTI6YPL181WverifiedProtein that relieves transcriptional repression by binding tothe Cyc8p-Tup1p corepressor and recruiting theSAGA complex to the repressed promoter;contains a PHD finger domain 0.013040.27397 S000004926NIP1YMR309CverifiedSubunit of the eukaryotic translation initiation factor 3(eIF3), involved in the assembly ofpreinitiation complex and start codon selection 0.012850.27231&radic&radic&radic S000001709VPS1YKR001CverifiedGTPase required for vacuolar protein sorting, functions inactin cytoskeleton organization via itsinteraction with Sla1p; required for lateGolgi-retention of some proteins includingKex2p; involved in regulating peroxisomebiogenesis 0.012690.26994&radic&radic&radic&radic&radic S000006393SKI3YPR189WverifiedProtein involved in exosome mediated 3' to 5' mRNA degradationand translation inhibition of non-poly(A)mRNAs; forms complex with Ski2p and Ski8p;required for repressing propagation of dsRNAviruses 0.012670.26994&radic&radic&radic&radic S000001650MRP49YKL167CverifiedMitochondrial ribosomal protein of the large subunit, notessential for mitochondrial translation 0.012790.26994&radic&radic&radic S000005842SFG1YOR315WverifiedNuclear protein, putative transcription factor required forgrowth of superficial pseudohyphae (which donot invade the agar substrate) but not forinvasive pseudohyphal growth; may act togetherwith Phd1p; potential Cdc28p substrate 0.012710.26994&radic&radic&radic&radic S000000146SEC17YBL050WverifiedPeripheral membrane protein required for vesicular transportbetween ER and Golgi and for the 'priming' stepin homotypic vacuole fusion, part of thecis-SNARE complex; has similarity to alpha-SNAP 0.012830.26994&radic&radic&radic&radic&radic S000003880JHD2YJR119CuncharacterizedPutative protein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to the cytoplasmand nucleus 0.012380.26492 S000004623MAC1YMR021CverifiedCopper-sensing transcription factor involved in regulation ofgenes required for high affinity coppertransport 0.012390.26492&radic&radic&radic&radic&radic&radic S000000157SKT5YBL061CverifiedActivator of Chs3p (chitin synthase III), recruits Chs3p to thebud neck via interaction with Bni4p; hassimilarity to Shc1p, which activates Chs3pduring sporulation 0.012480.26492&radic&radic&radic&radic&radic&radic S000001871BUD27YFL023WverifiedProtein involved in bud-site selection, nutrient signaling, andgene expression controlled by the TOR kinase;diploid mutants display a random buddingpattern instead of the wild-type bipolarpattern 0.012430.26492&radic&radic&radic&radic&radic&radic S000000950SPT15YER148WverifiedTATA-binding protein, general transcription factor thatinteracts with other factors to form thepreinitiation complex at promoters, essentialfor viability 0.012390.26492 S000000823RPN3YER021WverifiedEssential, non-ATPase regulatory subunit of the 26S proteasomelid, similar to the p58 subunit of the human26S proteasome; temperature-sensitive allelescause metaphase arrest, suggesting a role forthe proteasome in cell cycle control 0.012210.26492&radic&radic&radic S000004075ARP6YLR085CverifiedActin-related protein that binds nucleosomes; a component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.012080.26147&radic&radic S000002493SSS1YDR086CverifiedSubunit of the Sec61p translocation complex(Sec61p-Sss1p-Sbh1p) that forms a channel forpassage of secretory proteins through theendoplasmic reticulum membrane, and of theSsh1p complex (Ssh1p-Sbh2p-Sss1p); interactswith Ost4p and Wbp1p 0.012130.26147&radic&radic&radic S000001725YKR017CUncharacterizedPutative protein of unknown function; contains a RING finger motif 0.011950.26066&radic&radic&radic&radic&radic&radic&radic&radic S000001117PPE1YHR075CverifiedProtein with carboxyl methyl esterase activity that may have arole in demethylation of the phosphoproteinphosphatase catalytic subunit; also identifiedas a small subunit mitochondrial ribosomalprotein 0.01190.26066&radic&radic&radic S000001138HXT5YHR096CverifiedHexose transporter with moderate affinity for glucose, inducedin the presence of non-fermentable carbonsources, induced by a decrease in growth rate,contains an extended N-terminal domain relativeto other HXTs 0.011940.26066&radic&radic&radic&radic&radic S000002491TVP23YDR084CuncharacterizedIntegral membrane protein localized to late Golgi vesiclesalong with the v-SNARE Tlg2p; green fluorescentprotein (GFP)-fusion protein localizes to thecytoplasm in a punctate pattern 0.011840.2592&radic&radic&radic&radic&radic S000003247YGR015CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion 0.01180.2592&radic&radic&radic&radic&radic&radic S000004645ARG80YMR042WverifiedTranscription factor involved in regulation ofarginine-responsive genes; acts with Arg81p andArg82p 0.011580.25625&radic&radic&radic&radic&radic&radic S000001207DNA2YHR164CverifiedEssential tripartite DNA replication factor withsingle-stranded DNA-dependent ATPase,ATP-dependent nuclease, and helicaseactivities; required for Okazaki fragmentprocessing; involved in DNA repair pathways;potential Cdc28p substrate 0.011560.25625&radic&radic&radic&radic S000004161YLR171WDubiousHypothetical protein 0.011510.25588&radic&radic&radic&radic&radic S000004170SAM1YLR180WverifiedS-adenosylmethionine synthetase, catalyzes transfer of theadenosyl group of ATP to the sulfur atom ofmethionine; one of two differentially regulatedisozymes (Sam1p and Sam2p) 0.011480.25513&radic&radic&radic&radic S000001171ARP1YHR129CverifiedActin-related protein of the dynactin complex; required forspindle orientation and nuclear migration;putative ortholog of mammalian centractin 0.011430.25452&radic&radic&radic&radic&radic&radic S000005041PHO23YNL097CverifiedProbable component of the Rpd3 histone deacetylase complex,involved in transcriptional regulation of PHO5;C-terminus has similarity to human candidatetumor suppressor p33(ING1) 0.01140.25452 S000005583SGT1YOR057WverifiedProbable cochaperone, regulates activity of Cyr1p (adenylylcyclase); involved in assembly of thekinetochore complex, associates with the SCF(Skp1p/Cdc53p/F box protein) ubiquitin ligasecomplex 0.011340.25117&radic&radic&radic S000005366TOP1YOL006CverifiedTopoisomerase I, nuclear enzyme that relieves torsional strainin DNA by cleaving and re-sealing thephosphodiester backbone; relaxes bothpositively and negatively supercoiled DNA;functions in replication, transcription, andrecombination 0.011280.25117&radic&radic&radic&radic S000005527RRP6YOR001WverifiedExonuclease component of the nuclear exosome; contributes tothe quality-control system that retains anddegrades aberrant mRNAs in the nucleus 0.011250.25117&radic&radic&radic&radic&radic&radic&radic S000005825BUD7YOR299WverifiedMember of the Chs5p-Arf1p-binding proteins (ChAPs), a group of4 related, interacting proteins (Bch1p, Fmp50p,Bud7p, Chs6p) that mediate export of specificcargo proteins, including chitin synthaseChs3p, from the Golgi to plasma membrane 0.011290.25117&radic&radic&radic&radic&radic S000005551HST3YOR025WverifiedMember of the Sir2 family of NAD(+)-dependent proteindeacetylases; involved along with Hst4p intelomeric silencing, cell cycle progression,radiation resistance, genomic stability andshort-chain fatty acid metabolism 0.011050.24916&radic&radic&radic&radic&radic S000001220YHR177WUncharacterized 0.011010.24793&radic&radic&radic&radic&radic&radic S000004210CCC1YLR220WverifiedPutative vacuolar Fe2+/Mn2+ transporter; suppresses respiratorydeficit of yfh1 mutants, which lack theortholog of mammalian frataxin, by preventingmitochondrial iron accumulation 0.010940.24793&radic&radic&radic&radic&radic&radic&radic S000003263YGR031WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion 0.010880.247&radic&radic&radic S000004410CDC73YLR418CverifiedConstituent of Paf1 complex with RNA polymerase II, Paf1p,Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinctfrom Srb-containing Pol II complexes; requiredfor expression of certain genes, modificationof some histones, and telomere maintenance 0.010890.247&radic&radic&radic&radic S000001052RPL27AYHR010WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl27Bp and has similarity to ratL27 ribosomal protein 0.010920.247&radic&radic&radic&radic&radic S000001914YFR018CUncharacterizedHypothetical protein 0.010910.247&radic&radic&radic&radic&radic&radic&radic&radic S000002800SPT3YDR392WverifiedSubunit of the SAGA and SAGA-like transcriptional regulatorycomplexes, interacts with Spt15p to activatetranscription of some RNA polymeraseII-dependent genes, also functions to inhibittranscription at some promoters 0.010830.24634&radic&radic&radic S000004206CPR6YLR216CverifiedPeptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzesthe cis-trans isomerization of peptide bondsN-terminal to proline residues; binds to Hsp82pand contributes to chaperone activity 0.010810.24542&radic&radic&radic&radic&radic S000001745SPC34YKR037CverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; also localized tonuclear side of spindle pole body 0.010730.24488&radic&radic&radic&radic&radic&radic&radic S000000408YBR204CUncharacterizedSerine hydrolase; YBR204C is not an essential gene 0.010720.24488&radic&radic&radic&radic&radic S000000152PTC3YBL056WverifiedType 2C protein phosphatase; dephosphorylates Hog1p (see alsoPtc2p) to limit maximal kinase activity inducedby osmotic stress; dephosphorylates T169phosphorylated Cdc28p (see also Ptc2p); role inDNA checkpoint inactivation 0.010660.24336&radic&radic&radic&radic S000000400PGI1YBR196CverifiedGlycolytic enzyme phosphoglucose isomerase, catalyzes theinterconversion of glucose-6-phosphate andfructose-6-phosphate; required for cell cycleprogression and completion of the gluconeogenicevents of sporulation 0.010690.24336&radic&radic&radic&radic&radic S000000689CDC39YCR093WverifiedComponent of the CCR4-NOT complex, which has multiple roles inregulating mRNA levels including regulation oftranscription and destabilizing mRNAs bydeadenylation; basal transcription factor 0.010610.24336&radic&radic&radic&radic&radic&radic S000003332MDR1YGR100WverifiedCytoplasmic GTPase-activating protein for Ypt/Rab transportGTPases Ypt6p, Ypt31p and Sec4p; involved inrecycling of internalized proteins andregulation of Golgi secretory function 0.010550.24139&radic&radic&radic&radic S000000165AST1YBL069WverifiedPeripheral membrane protein that interacts with the plasmamembrane ATPase Pma1p and has a role in itstargeting to the plasma membrane, possibly byinfluencing its incorporation into lipid rafts 0.010450.24093&radic&radic&radic&radic&radic S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.010360.23964&radic&radic&radic&radic S000002568YDR161WUncharacterizedinteracts with PP2C 0.010370.23964&radic&radic&radic S000001694TRP3YKL211CverifiedBifunctional enzyme exhibiting both indole-3-glycerol-phosphatesynthase and anthranilate synthase activities,forms multifunctional hetero-oligomericanthranilate synthase:indole-3-glycerolphosphate synthase enzyme complex with Trp2p 0.010360.23964&radic&radic&radic&radic&radic&radic S000002198NAT1YDL040CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing &radic0.010320.23916 S000005388YAP7YOL028CverifiedPutative basic leucine zipper (bZIP) transcription factor 0.010340.23916&radic S000006032CAR1YPL111WverifiedArginase, responsible for arginine degradation, expressionresponds to both induction by arginine andnitrogen catabolite repression; disruptionenhances freeze tolerance 0.010290.23875&radic&radic&radic&radic&radic S000005805RFM1YOR279CverifiedDNA-binding protein required for vegetative repression ofmiddle sporulation genes; specificity factorthat directs the Hst1p histone deacetylase tosome of the promoters regulated by Sum1p;involved in telomere maintenance 0.010280.23875&radic&radic&radic&radic&radic&radic&radic S000001341AIR1YIL079CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p to regulate methylationof Npl3p, which modulates Npl3p function inmRNA processing and export; has similarity toAir2p 0.01020.23692&radic&radic&radic&radic&radic S000005568CUE5YOR042WuncharacterizedProtein containing a CUE domain that binds ubiquitin, which mayfacilitate intramolecular monoubiquitination;green fluorescent protein (GFP)-fusion proteinlocalizes to the cytoplasm in a punctatepattern 0.01020.23692&radic&radic&radic&radic&radic&radic S000003165MDS3YGL197WverifiedProtein with an N-terminal kelch-like domain, putative negativeregulator of early meiotic gene expression;required, with Pmd1p, for growth under alkalineconditions 0.010190.23692&radic&radic&radic&radic&radic&radic S000005424CRT10YOL063CverifiedProtein involved in transcriptional regulation of RNR2 andRNR3; expression of the gene is induced by DNAdamage and null mutations confer increasedresistance to hydroxyurea; N-terminal regionhas a leucine repeat and a WD40 repeat 0.010180.23692&radic&radic&radic&radic&radic&radic S000003011DST1YGL043WverifiedGeneral transcription elongation factor TFIIS, enables RNApolymerase II to read through blocks toelongation by stimulating cleavage of nascenttranscripts stalled at transcription arrestsites 0.010210.23692&radic&radic S000004239YEF3YLR249WverifiedTranslational elongation factor, stimulates the binding ofaminoacyl-tRNA (AA-tRNA) to ribosomes byreleasing EF-1 alpha from the ribosomalcomplex; contains two ABC cassettes; binds andhydrolyses ATP 0.01020.23692&radic&radic&radic&radic S000003210KAP114YGL241WverifiedKaryopherin, responsible for nuclear import of Spt15p, histonesH2A and H2B, and Nap1p; amino terminus showssimilarity to those of other importins,particularly Cse1p; localization is primarilynuclear 0.010080.23472&radic&radic&radic S000004283SEC72YLR292CverifiedNon-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66pand Sec72p); with Sec61 complex, Kar2p/BiP andLhs1p forms a channel competent forSRP-dependent and post-translationalSRP-independent protein targeting and importinto the ER 0.010010.23407&radic&radic&radic&radic S000006059SPP1YPL138CverifiedSubunit of COMPASS (Set1C), a complex which methylates histoneH3 on lysine 4 and is required in telomerictranscriptional silencing; PHD finger domainprotein similar to human CGBP, an unmethylatedCpG binding protein 0.009990.23407&radic&radic&radic S000000939YER137CUncharacterizedHypothetical protein 0.009950.23286 S000001577YJU3YKL094WverifiedSerine hydrolase with sequence similarity to monoglyceridelipase (MGL), localizes to lipid particles 0.009960.23286&radic&radic&radic&radic&radic S000002553SWI5YDR146CverifiedTranscription factor that activates transcription of genesexpressed at the M/G1 phase boundary and in G1phase; localization to the nucleus occursduring G1 and appears to be regulated byphosphorylation by Cdc28p kinase 0.009920.23225&radic&radic&radic&radic&radic&radic&radic&radic S000000612MAK32YCR019WverifiedProtein necessary for structural stability of L-Adouble-stranded RNA-containing particles 0.00980.23051&radic&radic&radic&radic&radic&radic S000004680RCO1YMR075WverifiedEssential subunit of the histone deacetylase Rpd3S complex;interacts with Eaf3p 0.009860.23051 S000004812CLN1YMR199WverifiedG1 cyclin involved in regulation of the cell cycle; activatesCdc28p kinase to promote the G1 to S phasetransition; late G1 specific expression dependson transcription factor complexes, MBF(Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) 0.009840.23051&radic&radic&radic&radic&radic&radic S000000513YCL007CDubiousDubious ORF unlikely to encode a protein; overlaps verified ORF YCL005W-A; mutations in YCL007C were thought to confer sensitivity to calcofluor white, but this phenotype was later shown to be due to the defect in YCL005W-A 0.009790.23051&radic&radic&radic&radic&radic S000000027MYO4YAL029CverifiedOne of two type V myosin motors (along with MYO2) involved inactin-based transport of cargos; required formRNA transport, including ASH1 mRNA, andfacilitating the growth and movement of ERtubules into the growing bud along with She3p 0.009860.23051&radic&radic&radic&radic S000005669THI80YOR143CverifiedThiamine pyrophosphokinase, phosphorylates thiamine to producethe coenzyme thiamine pyrophosphate (thiaminediphosphate) 0.009870.23051&radic&radic&radic&radic S000004617ERG5YMR015CverifiedC-22 sterol desaturase, a cytochrome P450 enzyme that catalyzesthe formation of the C-22(23) double bond inthe sterol side chain in ergosterolbiosynthesis; may be a target of azoleantifungal drugs 0.009740.22804&radic&radic&radic&radic&radic S000002538YDR131CUncharacterizedF-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex 0.009750.22804&radic&radic&radic&radic S000000882FMP29YER080WuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.009750.22804&radic&radic&radic&radic&radic&radic&radic&radic S000003262POP6YGR030CverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends 0.009570.22678&radic&radic&radic&radic&radic&radic&radic S000004818PFK2YMR205CverifiedBeta subunit of heterooctameric phosphofructokinase involved inglycolysis, indispensable for anaerobic growth,activated by fructose-2,6-bisphosphate and AMP,mutation inhibits glucose induction of cellcycle-related genes 0.009530.22571&radic&radic&radic&radic&radic&radic S000004280GUF1YLR289WverifiedMitochondrial GTPase of unknown function, similar to E. colielongation factor-type GTP-binding protein LepAand to LK1236.1 from Caenorhabditis elegans 0.009510.22571&radic&radic&radic&radic&radic S000002566SAC3YDR159WverifiedNuclear pore-associated protein, forms a complex with Thp1pthat is involved in transcription and in mRNAexport from the nucleus 0.009520.22571&radic&radic&radic&radic&radic&radic S000002652PEX5YDR244WverifiedPeroxisomal membrane signal receptor for C-terminal tripeptidesignal sequence (PTS1) of peroxisomal matrixproteins, required for peroxisomal matrixprotein import, tetratricopeptide repeatprotein, also involved in PTS1-independentimport 0.009520.22571&radic&radic&radic&radic&radic S000005553STI1YOR027WverifiedHsp90 cochaperone, interacts with the Ssa group of thecytosolic Hsp70 chaperones; activates theATPase activity of Ssa1p; homolog of mammalianHop protein 0.009430.22372&radic&radic&radic S000003518BIO2YGR286CverifiedBiotin synthase, catalyzes the conversion of dethiobiotin tobiotin, which is the last step of the biotinbiosynthesis pathway; complements E. coli bioBmutant 0.009440.22372&radic&radic&radic&radic&radic&radic S000005964NOP4YPL043WverifiedNucleolar protein, essential for processing and maturation of27S pre-rRNA and large ribosomal subunitbiogenesis; constituent of 66S pre-ribosomalparticles; contains four RNA recognition motifs(RRMs) 0.009330.22287&radic&radic&radic S000002461CDC34YDR054CverifiedUbiquitin-conjugating enzyme or E2; together with Skp1p, Rbx1p,Cdc53p, and an F-box protein, forms aubiquitin-protein ligase called the SCF complexwhich regulates cell cycle progression bytargeting key substrates for degradation 0.00920.22059&radic&radic&radic&radic&radic S000001359FYV10YIL097WverifiedProtein of unknown function, required for survival uponexposure to K1 killer toxin; involved inproteasome-dependent catabolite inactivation offructose-1,6-bisphosphatase; contains CTLHdomain 0.009270.22059&radic&radic&radic&radic&radic&radic&radic S000004833ERG8YMR220WverifiedPhosphomevalonate kinase, an essential cytosolic enzyme thatacts in the biosynthesis of isoprenoids andsterols, including ergosterol, from mevalonate 0.009210.22059&radic&radic&radic&radic&radic&radic S000003517ZUO1YGR285CverifiedCytosolic ribosome-associated chaperone that acts, togetherwith Ssz1p and the Ssb proteins, as a chaperonefor nascent polypeptide chains; contains a DnaJdomain and functions as a J-protein partner forSsb1p and Ssb2p 0.009210.22059&radic&radic&radic&radic S000000100UTP20YBL004WverifiedComponent of the small-subunit (SSU) processome, which isinvolved in the biogenesis of the 18S rRNA 0.009280.22059&radic&radic&radic&radic S000006319YPR115WUncharacterizedHypothetical protein 0.009160.2201&radic&radic&radic&radic&radic S000005059YNL115CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene 0.009140.21959 S000004144RNH203YLR154CverifiedRibonuclease H2 subunit, required for RNase H2 activity 0.009150.21959&radic&radic&radic&radic S000002532ECM18YDR125CverifiedProtein of unknown function, similar to Rlp24p 0.009130.21882&radic&radic&radic&radic S000005688YRR1YOR162CverifiedZn2-Cys6 zinc-finger transcription factor that activates genesinvolved in multidrug resistance; paralog ofYrm1p, acting on an overlapping set of targetgenes 0.009070.21791&radic&radic&radic&radic&radic&radic S000002101SFT1YKL006C-AverifiedIntra-Golgi v-SNARE, required for transport of proteins betweenan early and a later Golgi compartment 0.009040.2179&radic&radic&radic&radic&radic S000003951TPO1YLL028WverifiedPolyamine transporter that recognizes spermine, putrescine, andspermidine; catalyzes uptake of polyamines atalkaline pH and excretion at acidic pH;phosphorylation enhances activity and sortingto the plasma membrane 0.008980.21633&radic&radic&radic&radic&radic&radic S000005508SPT20YOL148CverifiedSubunit of the SAGA transcriptional regulatory complex,involved in maintaining the integrity of thecomplex 0.009040.21633 S000004395SFP1YLR403WverifiedTranscription factor that controls expression of many ribosomebiogenesis genes in response to nutrients andstress, regulates G2/M transitions duringmitotic cell cycle and DNA-damage response,involved in cell size modulation 0.008940.21589&radic&radic&radic&radic S000000391GDT1YBR187WuncharacterizedPutative protein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to the vacuole;YBR187W is an essential gene 0.008930.21542&radic&radic&radic&radic S000000211DSF2YBR007CuncharacterizedDeletion suppressor of mpt5 mutation 0.008860.21371 S000000764UTR4YEL038WverifiedProtein of unknown function, found in both the cytoplasm andnucleus 0.008830.21367&radic&radic&radic S000004034PDC1YLR044CverifiedMajor of three pyruvate decarboxylase isozymes, key enzyme inalcoholic fermentation, decarboxylates pyruvateto acetaldehyde; subject to glucose-, ethanol-,and autoregulation; involved in amino acidcatabolism 0.00880.2129&radic&radic&radic&radic&radic&radic S000000392NTC20YBR188CverifiedMember of a complex, including Prp19p, that binds to thespliceosome; required for pre-mRNA splicing 0.008790.2128&radic&radic&radic&radic&radic&radic S000002451HEM13YDR044WverifiedCoproporphyrinogen III oxidase, an oxygen requiring enzyme thatcatalyzes the sixth step in the hemebiosynthetic pathway; localizes to themitochondrial inner membrane; transcription isrepressed by oxygen and heme (via Rox1p andHap1p) 0.008660.21024 S000003362YGR130CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7) 0.008730.21024&radic&radic&radic&radic S000003164YGL196WUncharacterizedPutative protein of unknown function; deletion mutant is viable and has no detectable phenotype 0.008640.20976&radic&radic&radic&radic&radic&radic S000004156SEC10YLR166CverifiedEssential 100kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which has the essential function ofmediating polarized targeting of secretoryvesicles to active sites of exocytosis 0.008590.20873&radic&radic S000006235NTO1YPR031WuncharacterizedComponent of the histone acetyltransferase complex 0.00860.20873 S000004329VRP1YLR337CverifiedProline-rich actin-associated protein involved in cytoskeletalorganization and cytokinesis; related tomammalian Wiskott-Aldrich syndrome protein(WASP)-interacting protein (WIP) 0.008520.20814&radic&radic&radic&radic S000003956IRC19YLL033WuncharacterizedPutative protein of unknown function; YLL033W is not anessential gene but mutant is defective in sporeformation; null mutant displays increasedlevels of spontaneous Rad52 foci 0.008490.20686&radic&radic&radic S000005364SIN3YOL004WverifiedComponent of the Sin3p-Rpd3p histone deacetylase complex,involved in transcriptional repression andactivation of diverse processes, includingmating-type switching and meiosis; involved inthe maintenance of chromosomal integrity 0.008450.20662&radic&radic&radic&radic&radic S000003171KEX1YGL203CverifiedProtease involved in the processing of killer toxin and alphafactor precursor; cleaves Lys and Arg residuesfrom the C-terminus of peptides and proteins 0.008430.20607&radic&radic&radic&radic&radic&radic S000001676SDS22YKL193CverifiedConserved nuclear regulatory subunit of Glc7p type 1 proteinserine-threonine phosphatase (PP1), functionspositively with Glc7p to promotedephosphorylation of nuclear substratesrequired for chromosome transmission duringmitosis 0.008370.20493&radic&radic&radic&radic&radic&radic&radic&radic S000004820HFA1YMR207CverifiedMitochondrial acetyl-coenzyme A carboxylase, catalyzes theproduction of malonyl-CoA in mitochondrialfatty acid biosynthesis 0.008380.20493&radic&radic&radic S000003496MES1YGR264CverifiedMethionyl-tRNA synthetase, forms a complex with glutamyl-tRNAsynthetase (Gus1p) and Arc1p, which increasesthe catalytic efficiency of both tRNAsynthetases; also has a role in nuclear exportof tRNAs 0.008330.20473&radic&radic&radic&radic S000006048HHO1YPL127CverifiedHistone H1, a linker histone required for nucleosome packagingat restricted sites; suppresses DNA repairinvolving homologous recombination; notrequired for telomeric silencing, basaltranscriptional repression, or efficientsporulation 0.008290.20449&radic&radic&radic&radic&radic S000004842RRP5YMR229CverifiedProtein required for the synthesis of both 18S and 5.8S rRNA;C-terminal region is crucial for the formationof 18S rRNA and N-terminal region is requiredfor the 5.8S rRNA; component of small ribosomalsubunit (SSU) processosome 0.008210.20284&radic&radic&radic&radic S000000379SWD3YBR175WverifiedEssential subunit of the COMPASS (Set1C) complex, whichmethylates histone H3 on lysine 4 and isrequired in transcriptional silencing neartelomeres; WD40 beta propeller superfamilymember and ortholog of mammalian WDR5 0.008280.20284&radic&radic&radic&radic&radic S000005436MDM20YOL076WverifiedNon-catalytic subunit of the NatB N-terminal acetyltransferase,which catalyzes acetylation of theamino-terminal methionine residues of allproteins beginning with Met-Asp or Met-Glu andof some proteins beginning with Met-Asn orMet-Met; involved in mitochondrial inheritanceand actin assembly &radic0.008180.20226&radic&radic&radic&radic&radic&radic&radic S000001722YPT52YKR014CverifiedGTPase, similar to Ypt51p and Ypt53p and to mammalian rab5;required for vacuolar protein sorting andendocytosis 0.00810.20061&radic&radic&radic&radic&radic&radic&radic S000005895RAD17YOR368WverifiedCheckpoint protein, involved in the activation of the DNAdamage and meiotic pachytene checkpoints; withMec3p and Ddc1p, forms a clamp that is loadedonto partial duplex DNA; homolog of human andS. pombe Rad1 and U. maydis Rec1 proteins 0.008140.20061&radic&radic&radic&radic S000000770IES6YEL044WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.008110.20061&radic&radic&radic S000005985CWC27YPL064CverifiedComponent of a complex containing Cef1p, putatively involved inpre-mRNA splicing; has similarity to S. pombeCwf27p 0.008060.19915&radic&radic&radic&radic&radic&radic S000006149CET1YPL228WverifiedBeta (RNA 5'-triphosphatase) subunit of the mRNA cappingenzyme, a heterodimer (the other subunit isCEG1, a guanylyltransferase) involved in addingthe 5' cap to mRNA; the mammalian enzyme is asingle bifunctional polypeptide 0.008040.19915&radic&radic&radic&radic S000004467ERG6YML008CverifiedDelta(24)-sterol C-methyltransferase, converts zymosterol tofecosterol in the ergosterol biosyntheticpathway by methylating position C-24; localizedto both lipid particles and mitochondrial outermembrane 0.008050.19915&radic&radic&radic S000002842GPI17YDR434WverifiedTransmembrane protein subunit of theglycosylphosphatidylinositol transamidasecomplex that adds GPIs to newly synthesizedproteins; human PIG-Sp homolog 0.007940.198&radic&radic&radic&radic S000006131SRP72YPL210CverifiedCore component of the signal recognition particle (SRP)ribonucleoprotein (RNP) complex that functionsin targeting nascent secretory proteins to theendoplasmic reticulum (ER) membrane 0.00790.1972&radic S000004814RAD14YMR201CverifiedProtein that recognizes and binds damaged DNA during nucleotideexcision repair; subunit of Nucleotide ExcisionRepair Factor 1 (NEF1); contains zinc fingermotif; homolog of human XPA protein 0.007870.1972&radic&radic&radic&radic S000006186DIP5YPL265WverifiedDicarboxylic amino acid permease, mediates high-affinity andhigh-capacity transport of L-glutamate andL-aspartate; also a transporter for Gln, Asn,Ser, Ala, and Gly 0.007910.1972&radic&radic&radic&radic&radic S000006358PIN3YPR154WverifiedProtein that induces appearance of [PIN+] prion whenoverproduced 0.007830.19683&radic&radic&radic&radic&radic S000001498PUT3YKL015WverifiedTranscriptional activator of proline utilization genes,constitutively binds PUT1 and PUT2 promotersequences and undergoes a conformational changeto form the active state; has a Zn(2)-Cys(6)binuclear cluster domain 0.007730.19466&radic&radic&radic&radic&radic&radic S000001930PHO4YFR034CverifiedBasic helix-loop-helix (bHLH) transcription factor; bindscooperatively with Pho2p to the PHO5 promoter;function is regulated by phosphorylation atmultiple sites and by phosphate availability 0.007760.19466&radic&radic&radic&radic S000005505CTR9YOL145CverifiedComponent of the Paf1p complex, which is a large complex thatbinds to and modulates the activity of RNApolymerase II and is required for expression ofa subset of genes, including cyclin genes;contains TPR repeats 0.007680.1942 S000004230VPS34YLR240WverifiedPhosphatidylinositol 3-kinase responsible for the synthesis ofphosphatidylinositol 3-phosphate; formsmembrane-associated signal transduction complexwith Vps15p to regulate protein sorting;activated by the GTP-bound form of Gpa1p 0.007660.19403&radic&radic&radic&radic&radic S000000099HTA2YBL003CverifiedOne of two nearly identical (see also HTA1) histone H2Asubtypes; core histone required for chromatinassembly and chromosome function; DNAdamage-dependent phosphorylation by Mec1pfacilitates DNA repair; acetylated by Nat4p 0.007650.19335&radic&radic&radic&radic&radic S000005257YNL313CUncharacterizedProtein required for cell viability 0.007650.19335&radic&radic&radic&radic&radic&radic&radic S000002711RSC3YDR303CverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; essential gene required forregulation of ribosomal protein genes and thecell wall/stress response; highly similar toRsc30p 0.007650.19335&radic&radic&radic&radic S000000870MOT2YER068WverifiedComponent of the CCR4-NOT complex, which has multiple roles intranscription regulation, mRNA degradation, andpost-transcriptional modifications; with Ubc4p,ubiquitylates subunits of the nascentpolypeptide-associated complex (NAC) 0.007550.19151&radic&radic&radic S000002603REF2YDR195WverifiedRNA-binding protein involved in the cleavage step of mRNA3'-end formation prior to polyadenylation, andin snoRNA maturation; part of holo-CPFsubcomplex APT, which associates with 3'-endsof snoRNA- and mRNA-encoding genes 0.007570.19151&radic&radic&radic&radic S000001335SPO22YIL073CverifiedMeiosis-specific protein essential for chromosome synapsis,similar to phospholipase A2, involved incompletion of nuclear divisions during meiosis;induced early in meiosis 0.007520.19111&radic&radic&radic&radic&radic&radic S000002540YDR133CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C 0.007510.19111&radic&radic S000001578YJU2YKL095WverifiedEssential nuclear protein; putative spliceosomal componentinvolved in mRNA splicing, based oncomputational analysis of large-scaleprotein-protein interaction data 0.007510.19111&radic&radic&radic&radic&radic&radic&radic&radic S000000213HHF1YBR009CverifiedOne of two identical histone H4 proteins (see also HHF2); corehistone required for chromatin assembly andchromosome function; contributes to telomericsilencing; N-terminal domain involved inmaintaining genomic integrity 0.007480.19052 S000003388PTI1YGR156WverifiedPta1p Interacting protein 0.007470.19046&radic&radic&radic S000005205ORC5YNL261WverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing 0.007460.19018&radic&radic&radic&radic S000000850CAJ1YER048CverifiedNuclear type II J heat shock protein of the E. coli dnaJfamily, contains a leucine zipper-like motif,binds to non-native substrates for presentationto Ssa3p, may function during proteintranslocation, assembly and disassembly 0.007410.18924&radic&radic S000003935YEH1YLL012WverifiedSteryl ester hydrolase, one of three gene products (Yeh1p,Yeh2p, Tgl1p) responsible for steryl esterhydrolase activity and involved in sterolhomeostasis; localized to lipid particlemembranes 0.007380.18883&radic&radic&radic&radic&radic&radic&radic S000002635SIR4YDR227WverifiedSilent information regulator that, together with SIR2 and SIR3,is involved in assembly of silent chromatindomains at telomeres and the silent mating-typeloci; potentially phosphorylated by Cdc28p;some alleles of SIR4 prolong lifespan 0.007380.18883&radic&radic&radic&radic&radic S000002615UME6YDR207CverifiedKey transcriptional regulator of early meiotic genes, bindsURS1 upstream regulatory sequence, couplesmetabolic responses to nutritional cues withinitiation and progression of meiosis, formscomplex with Ime1p, and also with Sin3p-Rpd3p 0.007360.18791&radic&radic&radic S000003793CPR7YJR032WverifiedPeptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzesthe cis-trans isomerization of peptide bondsN-terminal to proline residues; binds to Hsp82pand contributes to chaperone activity 0.007320.18734 S000001689ADD66YKL206CuncharacterizedProtein of unknown function involved in ER-associated proteindegradation; green fluorescent protein(GFP)-fusion protein localizes to the cytoplasm 0.007310.18734&radic&radic&radic&radic&radic&radic&radic S000004494RAD52YML032CverifiedProtein that stimulates strand exchange by facilitating Rad51pbinding to single-stranded DNA; annealscomplementary single-stranded DNA; involved inthe repair of double-strand breaks in DNAduring vegetative growth and meiosis 0.007320.18734&radic&radic&radic&radic S000002789YRA1YDR381WverifiedNuclear protein that binds to RNA and to Mex67p, required forexport of poly(A)+ mRNA from the nucleus;member of the REF (RNA and export factorbinding proteins) family; another familymember, Yra2p, can substitute for Yra1pfunction 0.007240.18582&radic&radic&radic S000000638TAF2YCR042CverifiedTFIID subunit (150 kDa), involved in RNA polymerase IItranscription initiation 0.007280.18582 S000000781POL5YEL055CverifiedProtein with sequence similarity to the human MybBP1A and weaksequence similar to B-type DNA polymerases, notrequired for chromosomal DNA replication;required for the synthesis of rRNA 0.007230.18582&radic&radic&radic&radic&radic&radic&radic S000001159TOM71YHR117WverifiedMitochondrial outer membrane protein with similarity to Tom70p;probable minor component of the TOM(translocase of outer membrane) complexresponsible for recognition and import ofmitochondrially directed proteins 0.007260.18582&radic S000001609YPK1YKL126WverifiedSerine/threonine protein kinase required for receptor-mediatedendocytosis; involved in sphingolipid-mediatedand cell integrity signaling pathways;localized to the bud neck, cytosol and plasmamembrane; homolog of mammalian kinase SGK 0.007190.18524&radic&radic&radic&radic&radic&radic&radic S000006099CBC2YPL178WverifiedSmall subunit of the heterodimeric cap binding complex thatalso contains Sto1p, component of thespliceosomal commitment complex; interacts withNpl3p, possibly to package mRNA for export fromthe nucleus; contains an RNA-binding motif 0.007150.18431&radic&radic S000003342YGR110WUncharacterizedPutative protein of unknown function; transcription is increased in response to genotoxic stress 0.007180.18431 S000002755MRP1YDR347WverifiedMitochondrial ribosomal protein of the small subunit; MRP1exhibits genetic interactions with PET122,encoding a COX3-specific translationalactivator, and with PET123, encoding a smallsubunit mitochondrial ribosomal protein 0.007150.18431&radic&radic S000004229LIP2YLR239CverifiedLipoyl ligase, involved in the modification of mitochondrialenzymes by the attachment of lipoic acid groups 0.007120.18406&radic&radic&radic&radic&radic&radic&radic S000001623TGL1YKL140WverifiedSteryl ester hydrolase, one of three gene products (Yeh1p,Yeh2p, Tgl1p) responsible for steryl esterhydrolase activity and involved in sterolhomeostasis; localized to lipid particlemembranes 0.00710.18319&radic&radic&radic&radic&radic S000002824SYF1YDR416WverifiedComponent of the spliceosome complex involved in pre-mRNAsplicing; involved in regulation of cell cycleprogression; similar to Drosophila crooked neckprotein 0.007080.18314&radic&radic&radic S000000064SWD1YAR003WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres; WD40beta propeller superfamily member withsimilarity to mammalian Rbbp7 0.007080.18264&radic&radic&radic&radic&radic&radic S000004216BUR2YLR226WverifiedCyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2pcomprise a CDK-cyclin complex involved intranscriptional regulation through itsphosphorylation of the carboxy-terminal domainof the largest subunit of RNA polymerase II 0.006970.18016&radic&radic&radic&radic&radic S000005700MED4YOR174WverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation 0.006970.18016&radic&radic&radic&radic&radic&radic S000003993YLR003CUncharacterizedPutative protein of unknown function that may participate in DNA replication; green fluorescent protein (GFP)-fusion protein is localized to the nucleus; YLR003C is not an essential gene 0.006980.18016&radic&radic&radic&radic&radic S000004896RIT1YMR283Cverified2'-O-ribosyl phosphate transferase, modifies the initiatormethionine tRNA at position 64 to distinguishit from elongator methionine tRNA 0.006980.18016&radic&radic&radic&radic&radic&radic&radic&radic&radic S000001072SLT2YHR030CverifiedSerine/threonine MAP kinase involved in regulating themaintenance of cell wall integrity andprogression through the cell cycle; regulatedby the PKC1-mediated signaling pathway 0.006910.17959&radic&radic&radic&radic&radic&radic S000004363ROM2YLR371WverifiedGDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutationsare synthetically lethal with mutations inrom1, which also encodes a GEP 0.006910.17959&radic&radic&radic S000000602RVS161YCR009CverifiedAmphiphysin-like lipid raft protein; subunit of a complex(Rvs161p-Rvs167p) that regulates polarizationof the actin cytoskeleton, endocytosis, cellpolarity, cell fusion and viability followingstarvation or osmotic stress 0.006910.17959&radic&radic S000001783YKR075CUncharacterizedProtein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p 0.006910.17959&radic&radic S000005606DIA2YOR080WverifiedOrigin-binding F-box protein that forms an SCF ubiquitin ligasecomplex with Skp1p and Cdc53p; plays a role inDNA replication, involved in invasive andpseudohyphal growth 0.006890.17933&radic&radic&radic&radic S000005739SAS5YOR213CverifiedSubunit of the SAS complex (Sas2p, Sas4p, Sas5p), whichacetylates free histones and nucleosomes andregulates transcriptional silencing; stimulatesSas2p HAT activity &radic0.006880.17829&radic&radic&radic&radic&radic&radic&radic S000005968SGF11YPL047WverifiedIntegral subunit of SAGA histone acetyltransferase complex,regulates transcription of a subset ofSAGA-regulated genes, required for the Ubp8passociation with SAGA and for H2Bdeubiquitylation 0.006860.17829&radic&radic&radic S000004191COQ9YLR201CverifiedMitochondrial inner membrane protein required for ubiquinone(coenzyme Q) biosynthesis, which in turn isrequired for respiratory growth; exhibitsgenetic interaction with ABC1, suggesting apossible common function 0.006880.17829&radic&radic&radic S000002708PRO1YDR300CverifiedGamma-glutamyl kinase, catalyzes the first step in prolinebiosynthesis 0.006830.17829&radic&radic&radic&radic&radic S000001948RPN12YFR052WverifiedSubunit of the 19S regulatory particle of the 26S proteasomelid; synthetically lethal with RPT1, which isan ATPase component of the 19S regulatoryparticle; physically interacts with Nob1p andRpn3p 0.00680.17733&radic&radic&radic S000003924DNM1YLL001WverifiedDynamin-related GTPase required for mitochondrial fission andthe maintenance of mitochondrial morphology,assembles on the cytoplasmic face ofmitochondrial tubules at sites at whichdivision will occur; also participates inendocytosis 0.006790.17733&radic&radic&radic&radic&radic S000002164PTC1YDL006WverifiedType 2C protein phosphatase (PP2C); inactivates the osmosensingMAPK cascade by dephosphorylating Hog1p;mutation delays mitochondrial inheritance;deletion reveals defects in precursor tRNAsplicing, sporulation and cell separation 0.006740.17605 S000000425PDB1YBR221CverifiedE1 beta subunit of the pyruvate dehydrogenase (PDH) complex,which is an evolutionarily-conservedmulti-protein complex found in mitochondria 0.00660.17302&radic&radic&radic&radic&radic&radic S000003925RTT109YLL002WverifiedProtein with a role in regulation of Ty1 transposition 0.006620.17302&radic&radic&radic&radic&radic&radic S000001014SPO11YHL022CverifiedMeiosis-specific protein that initiates meiotic recombinationby catalyzing the formation of double-strandbreaks in DNA via a transesterificationreaction; required for homologous chromosomepairing and synaptonemal complex formation 0.006610.17302&radic&radic&radic S000000112FUS3YBL016WverifiedMitogen-activated protein kinase involved in mating pheromoneresponse; activated by phosphorylation bySte7p; provides specificity during the matingvs. filamentous growth response byphosphorylating transcriptional and cytoplasmictargets 0.006560.17263&radic&radic&radic&radic&radic S000004788ECM5YMR176WverifiedNon-essential protein of unknown function, containsATP/GTP-binding site motif A; null mutantexhibits cellular volume up to four timesgreater than wild-type, also large droopingbuds with elongated necks 0.006560.17263&radic&radic S000000734YEL008WDubiousHypothetical protein predicted to be involved in metabolism 0.006550.17259&radic&radic&radic&radic&radic&radic S000000881YER079WUncharacterizedHypothetical protein 0.006550.17258&radic&radic&radic&radic&radic&radic&radic S000002458YDR051CUncharacterizedHypothetical protein 0.006550.17258&radic&radic&radic&radic&radic&radic&radic&radic S000005667ARP8YOR141CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes 0.006550.1724&radic&radic&radic&radic S000002594YDR186CUncharacterizedHypothetical protein 0.006490.17149&radic&radic&radic S000000457SRB6YBR253WverifiedEssentital subunit of the RNA polymerase II mediator complex;associates with core polymerase subunits toform the RNA polymerase II holoenzyme;essential for transcriptional regulation 0.006510.17149&radic&radic&radic&radic&radic S000001714MRPL13YKR006CverifiedMitochondrial ribosomal protein of the large subunit, notessential for mitochondrial translation 0.006540.17149&radic&radic&radic&radic&radic&radic&radic&radic S000002838CYM1YDR430CverifiedLysine-specific metalloprotease of the mitochondrialintermembrane space, member of the pitrilysinfamily; degrades proteins and presequencepeptides cleaved from imported proteins;required for normal mitochondrial morphology 0.006530.17149&radic&radic&radic S000003430YPP1YGR198WverifiedCargo-transport protein involved in endocytosis; may interactwith ribosomes, based on co-purificationexperiments; GFP-fusion protein localizes tothe cytoplasm; YGR198W is an essential gene 0.006490.17149&radic&radic&radic&radic&radic S000004046ERG3YLR056WverifiedC-5 sterol desaturase, catalyzes the introduction of a C-5(6)double bond into episterol, a precursor inergosterol biosynthesis; mutants are viable,but cannot grow on non-fermentable carbonsources 0.006440.17044&radic&radic S000003412RNR4YGR180CverifiedRibonucleotide-diphosphate reductase (RNR), small subunit; theRNR complex catalyzes the rate-limiting step indNTP synthesis and is regulated by DNAreplication and DNA damage checkpoint pathwaysvia localization of the small subunits 0.006460.17044&radic&radic&radic&radic&radic S000003959PRP19YLL036CverifiedSplicing factor associated with the spliceosome; contains aU-box, a motif found in a class of ubiquitinligases 0.006460.17044&radic&radic&radic&radic&radic&radic&radic&radic S000001163LSM12YHR121WverifiedProtein of unknown function that interacts with Pbp1p and Pbp4pand associates with ribosomes; contains anRNA-binding LSM domain and an AD domain; mayplay a role in RNA processing 0.006430.1702&radic&radic&radic&radic&radic&radic S000003326VAS1YGR094WverifiedMitochondrial and cytoplasmic valyl-tRNA synthetase 0.006430.1702&radic&radic&radic&radic&radic S000001695SAC1YKL212WverifiedLipid phosphoinositide phosphatase of the ER and Golgi,involved in protein trafficking and secretion 0.006430.17019&radic&radic&radic&radic&radic S000002589SAS4YDR181CverifiedSubunit of the SAS complex (Sas2p, Sas4p, Sas5p), whichacetylates free histones and nucleosomes andregulates transcriptional silencing; requiredfor the HAT activity of Sas2p &radic0.006420.17009&radic&radic&radic&radic&radic S000005976LGE1YPL055CverifiedProtein of unknown function; null mutant forms abnormally largecells 0.006420.17009&radic&radic&radic&radic&radic S000001358YIL096CUncharacterizedPutative protein of unknown function; associates with precursors of the 60S ribosomal subunit 0.006380.16913&radic&radic&radic&radic&radic S000003413TIM13YGR181WverifiedMitochondrial intermembrane space protein, forms a complex withTIm8p that mediates import and insertion of asubset of polytopic inner membrane proteins;may prevent aggregation of incoming proteins ina chaperone-like manner 0.006380.16913&radic&radic&radic&radic&radic S000000699YCR102CUncharacterizedPutative protein of unknown function; involved in copper metabolism; similar to C.carbonum toxD gene; YCR102C is not an essential gene 0.006340.16823&radic&radic&radic&radic&radic&radic&radic S000003383YGR151CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C 0.00630.16738&radic&radic&radic S000000853JHD1YER051WverifiedJmjC domain family histone demethylase specific for H3-K36,similar to proteins found in human, mouse,drosophila, X. laevis, C. elegans, and S. pombe 0.00630.16738&radic&radic&radic S000000259PRP6YBR055CverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.006290.1666 S000005933RRP12YPL012WverifiedProtein required for export of the ribosomal subunits;associates with the RNA components of thepre-ribosomes; contains HEAT-repeats 0.006290.1666&radic&radic&radic&radic&radic&radic S000004889DSK2YMR276WverifiedNuclear-enriched ubiquitin-like polyubiquitin-binding protein,required for spindle pole body (SPB)duplication and for transit through the G2/Mphase of the cell cycle, involved inproteolysis, interacts with the proteasome 0.006270.1666&radic&radic&radic&radic S000005199GIS2YNL255CverifiedProtein with seven cysteine-rich CCHC zinc-finger motifs,similar to human CNBP, proposed to be involvedin the RAS/cAMP signaling pathway 0.006290.1666&radic&radic&radic&radic S000005216SEC2YNL272CverifiedGuanyl-nucleotide exchange factor for the small G-proteinSec4p, located on cytoplasmic vesicles;essential for post-Golgi vesicle transport 0.006210.16563&radic&radic&radic&radic&radic&radic&radic S000006003MOT1YPL082CverifiedEssential abundant protein involved in regulation oftranscription, removes Spt15p (TBP) from DNAvia its C-terminal ATPase activity, forms acomplex with TBP that binds TATA DNA with highaffinity but with altered specificity 0.006160.16432&radic&radic&radic&radic&radic S000001737SET3YKR029CverifiedDefining member of the SET3 histone deacetylase complex whichis a meiosis-specific repressor of sporulationgenes; necessary for efficient transcription byRNAPII; one of two yeast proteins that containsboth SET and PHD domains 0.006160.16432 S000003424TDH3YGR192CverifiedGlyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involvedin glycolysis and gluconeogenesis; tetramerthat catalyzes the reaction ofglyceraldehyde-3-phosphate to 1,3bis-phosphoglycerate; detected in the cytoplasmand cell-wall 0.006080.16123&radic&radic&radic&radic&radic S000001735BCH2YKR027WverifiedMember of the Chs5p-Arf1p-binding proteins (ChAPs), a group of4 related, interacting proteins (Bch1p, Fmp50p,Bud7p, Chs6p) that mediate export of specificcargo proteins, including chitin synthaseChs3p, from the Golgi to plasma membrane 0.006130.16123 S000002829ARO80YDR421WverifiedZinc finger transcriptional activator of the Zn2Cys6 family;activates transcription of aromatic amino acidcatabolic genes in the presence of aromaticamino acids 0.006080.16123&radic&radic&radic&radic&radic S000005720TOA1YOR194CverifiedTFIIA large subunit; involved in transcriptional activation,acts as antirepressor or as coactivator;homologous to largest and second largestsubunits of human and Drosophila TFIIA 0.006120.16123&radic&radic&radic&radic S000000816HEM14YER014WverifiedProtoporphyrinogen oxidase, a mitochondrial enzyme thatcatalyzes the seventh step in the hemebiosynthetic pathway, convertingprotoporphyrinogen IX to protoporphyrin IX 0.006020.16123&radic&radic&radic&radic&radic&radic S000000435SWC5YBR231CuncharacterizedProtein of unknown function, component of the SWR1 complex,which exchanges histone variant H2AZ (Htz1p)for chromatin-bound histone H2A 0.006130.16123&radic&radic&radic&radic&radic S000000009SWC3YAL011WverifiedProtein of unknown function, component of the SWR1 complex,which exchanges histone variant H2AZ (Htz1p)for chromatin-bound histone H2A; required forformation of nuclear-associated array of smoothendoplasmic reticulum known as karmellae 0.006110.16123&radic&radic&radic&radic&radic S000000615HSP30YCR021CverifiedHydrophobic plasma membrane localized, stress-responsiveprotein that negatively regulates theH(+)-ATPase Pma1p; induced by heat shock,ethanol treatment, weak organic acid, glucoselimitation, and entry into stationary phase 0.006080.16123&radic&radic&radic&radic&radic&radic S000002761TRR1YDR353WverifiedCytoplasmic thioredoxin reductase, key regulatory enzyme thatdetermines the redox state of the thioredoxinsystem, which acts as a disulfide reductasesystem and protects cells against bothoxidative and reductive stress 0.006130.16123&radic&radic&radic&radic&radic&radic S000002633HTA1YDR225WverifiedOne of two nearly identical (see also HTA2) histone H2Asubtypes; core histone required for chromatinassembly and chromosome function; DNAdamage-dependent phosphorylation by Mec1pfacilitates DNA repair; acetylated by Nat4p 0.00610.16123&radic&radic&radic&radic&radic S000001231GPI16YHR188CverifiedTransmembrane protein subunit of theglycosylphosphatidylinositol transamidasecomplex that adds GPIs to newly synthesizedproteins; human PIG-Tp homolog 0.006010.16099&radic&radic&radic&radic&radic S000005888PRT1YOR361CverifiedSubunit of the core complex of translation initiation factor3(eIF3), essential for translation; part of asubcomplex (Prt1p-Rpg1p-Nip1p) that stimulatesbinding of mRNA and tRNA(i)Met to ribosomes 0.005970.15999&radic&radic&radic&radic&radic S000000782HAT2YEL056WverifiedSubunit of the Hat1p-Hat2p histone acetyltransferase complex;required for high affinity binding of thecomplex to free histone H4, thereby enhancingHat1p activity; similar to human RbAp46 and 48;has a role in telomeric silencing &radic0.005960.15958&radic&radic&radic S000003455HSV2YGR223CverifiedPhosphatidylinositol 3,5-bisphosphate-binding protein,predicted to fold as a seven-bladedbeta-propeller; displays punctate cytoplasmiclocalization 0.005950.15958&radic&radic&radic&radic&radic S000001541TOA2YKL058WverifiedTFIIA small subunit; involved in transcriptional activation,acts as antirepressor or as coactivator;homologous to smallest subunit of human andDrosophila TFIIA 0.005930.15814&radic&radic&radic&radic&radic S000004876SAP30YMR263WverifiedSubunit of a histone deacetylase complex, along with Rpd3p andSin3p, that is involved in silencing attelomeres, rDNA, and silent mating-type loci;involved in telomere maintenance 0.00590.15814&radic&radic&radic&radic&radic S000004264CDC46YLR274WverifiedComponent of the hexameric MCM complex, which is important forpriming origins of DNA replication in G1 andbecomes an active ATP-dependent helicase thatpromotes DNA melting and elongation whenactivated by Cdc7p-Dbf4p in S-phase 0.005920.15814&radic&radic&radic&radic&radic S000005621RKI1YOR095CverifiedRibose-5-phosphate ketol-isomerase, catalyzes theinterconversion of ribose 5-phosphate andribulose 5-phosphate in the pentose phosphatepathway; participates in pyridoxinebiosynthesis 0.005890.15796&radic&radic&radic S000005735NPT1YOR209CverifiedNicotinate phosphoribosyltransferase, acts in the salvagepathway of NAD+ biosynthesis; required forsilencing at rDNA and telomeres and has a rolein silencing at mating-type loci; localized tothe nucleus 0.005890.15796&radic&radic&radic S000001355RSM25YIL093CverifiedMitochondrial ribosomal protein of the small subunit 0.005830.15669&radic&radic&radic&radic&radic&radic S000001762DYN1YKR054CverifiedCytoplasmic heavy chain dynein, microtubule motor protein,required for anaphase spindle elongation;involved in spindle assembly, chromosomemovement, and spindle orientation during celldivision, targeted to microtubule tips by Pac1p 0.005820.15631&radic&radic&radic&radic S000002463YDR056CUncharacterizedHypothetical protein 0.00580.15618&radic&radic&radic&radic&radic&radic S000005587CKA2YOR061WverifiedAlpha' catalytic subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKB1 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.005760.15445&radic&radic&radic&radic&radic&radic&radic S000001719YKR011CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus 0.005770.15445&radic&radic&radic&radic&radic S000003026RAD6YGL058WverifiedUbiquitin-conjugating enzyme (E2), involved in postreplicationrepair (with Rad18p), sporulation, telomeresilencing, and ubiquitin-mediated N-end ruleprotein degradation (with Ubr1p) 0.005760.15445&radic&radic&radic S000001909IOC3YFR013WverifiedMember of a complex (Isw1a) with Isw1p that hasnucleosome-stimulated ATPase activity andrepresses transcription initiation by specificpositioning of a promoter proximaldinucleosome; has homology to Esc8p, which isinvolved in silencing 0.005740.15445&radic&radic&radic&radic&radic&radic&radic S000002674YDR266CUncharacterizedHypothetical protein 0.005770.15445&radic&radic&radic&radic&radic&radic&radic S000002624ADR1YDR216WverifiedCarbon source-responsive zinc-finger transcription factor,required for transcription of theglucose-repressed gene ADH2, of peroxisomalprotein genes, and of genes required forethanol, glycerol, and fatty acid utilization 0.005740.15445&radic&radic&radic S000000189ROX3YBL093CverifiedRNA polymerase II holoenzyme component 0.005720.15383&radic&radic&radic&radic&radic S000004089ICT1YLR099CverifiedProtein of unknown function, null mutation leads to an increasein sensitivity to Calcofluor white; expressionof the gene is induced in the presence ofisooctane 0.005690.15334&radic&radic&radic S000004802SGS1YMR190CverifiedNucleolar DNA helicase of the RecQ family involved inmaintenance of genome integrity, regulateschromosome synapsis and meiotic crossing over;has similarity to human BLM and WRN helicasesimplicated in Bloom and Werner syndromes 0.005680.1528&radic&radic&radic&radic&radic S000000787CIN8YEL061CverifiedKinesin motor protein involved in mitotic spindle assembly andchromosome segregation 0.005640.15084&radic&radic&radic&radic S000001732DBP7YKR024CverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in ribosomal biogenesis 0.005640.15084&radic&radic&radic&radic&radic&radic&radic S000005882GDS1YOR355WverifiedProtein of unknown function, required for growth on glycerol asa carbon source; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.005650.15084&radic&radic&radic&radic&radic S000005124RHO5YNL180CverifiedNon-essential small GTPase of the Rho/Rac subfamily of Ras-likeproteins, likely involved in protein kinase C(Pkc1p)-dependent signal transduction pathwaythat controls cell integrity 0.005530.14922&radic&radic&radic&radic&radic S000000819AFG3YER017CverifiedComponent, with Yta12p, of the mitochondrial inner membranem-AAA protease that mediates degradation ofmisfolded or unassembled proteins and is alsorequired for correct assembly of mitochondrialenzyme complexes 0.00550.1479&radic&radic&radic&radic&radic&radic&radic S000003481MGA1YGR249WverifiedProtein similar to heat shock transcription factor; multicopysuppressor of pseudohyphal growth defects ofammonium permease mutants 0.005520.1479&radic&radic&radic&radic&radic&radic S000003175SPT16YGL207WverifiedSubunit of the heterodimeric FACT complex (Spt16p-Pob3p),facilitates RNA Polymerase II transcriptionelongation through nucleosomes by destabilizingand then reassembling nucleosome structure 0.00550.1479&radic&radic&radic S000003483YGR251WUncharacterizedPutative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene 0.005470.14757&radic&radic&radic&radic&radic&radic S000002632HTB1YDR224CverifiedOne of two nearly identical (see HTB2) histone H2B subtypesrequired for chromatin assembly and chromosomefunction; Rad6p-Bre1p-Lge1p mediatedubiquitination regulates transcriptionalactivation, meiotic DSB formation and H3methylation 0.005470.14757&radic&radic&radic&radic&radic&radic&radic S000004096MDN1YLR106CverifiedHuge dynein-related AAA-type ATPase (midasin), forms extendedpre-60S particle with the Rix1 complex(Rix1p-Ipi1p-Ipi3p), may mediate ATP-dependentremodeling of 60S subunits and subsequentexport from nucleoplasm to cytoplasm 0.005420.14592&radic&radic&radic S000001564TEF4YKL081WverifiedTranslation elongation factor EF-1 gamma 0.005450.14592&radic&radic&radic&radic&radic&radic&radic S000004169YLR179CUncharacterizedProtein of unknown function, transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus; YLR179C is not essential 0.005440.14592&radic&radic&radic&radic&radic&radic S000005787RPN8YOR261CverifiedEssential, non-ATPase regulatory subunit of the 26S proteasome;has similarity to the human p40 proteasomalsubunit and to another S. cerevisiae regulatorysubunit, Rpn11p 0.00540.14568&radic&radic S000004190YKE2YLR200WverifiedSubunit of the heterohexameric Gim/prefoldin protein complexinvolved in the folding of alpha-tubulin,beta-tubulin, and actin 0.005380.14519&radic&radic&radic&radic S000003560PET130YJL023CverifiedProtein required for respiratory growth; the authentic,non-tagged protein is detected in highlypurified mitochondria in high-throughputstudies 0.005380.14519 S000002334AIR2YDL175CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p; may regulatemethylation of Npl3p, which modulates Npl3pfunction in mRNA processing and export; hassimilarity to Air1p 0.005340.14409 S000002968LSB3YFR024C-AverifiedProtein containing a C-terminal SH3 domain; binds Las17p, whichis a homolog of human Wiskott-Aldrich Syndromeprotein involved in actin patch assembly andactin polymerization 0.005310.14322&radic&radic&radic&radic&radic&radic S000002172NOP1YDL014WverifiedNucleolar protein, component of the small subunit processomecomplex, which is required for processing ofpre-18S rRNA; has similarity to mammalianfibrillarin 0.00530.14305 S000005347YNR064CVerifiedEpoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides 0.005270.14244 S000001771LAS1YKR063CverifiedEssential nuclear protein possibly involved in bud formationand morphogenesis; mutants require the SSD1-vallele for viability 0.005260.14218&radic&radic&radic&radic&radic&radic&radic S000001756NAP1YKR048CverifiedProtein that interacts with mitotic cyclin Clb2p; required forthe regulation of microtubule dynamics duringmitosis; controls bud morphogenesis; involvedin the transport of H2A and H2B histones to thenucleus 0.005260.14178&radic&radic&radic&radic&radic&radic S000000011DEP1YAL013WverifiedTranscriptional modulator involved in regulation of structuralphospholipid biosynthesis genes andmetabolically unrelated genes, as well asmaintenance of telomeres, mating efficiency,and sporulation 0.005250.14178&radic&radic&radic&radic&radic S000001346SDS3YIL084CverifiedComponent of the Rpd3p/Sin3p deacetylase complex required forits structural integrity and catalyticactivity, involved in transcriptional silencingand required for sporulation; cells defectivein SDS3 display pleiotropic phenotypes 0.005240.14162&radic&radic S000001029YHL037CDubiousHypothetical protein 0.005220.14111&radic&radic&radic&radic&radic&radic S000000534BIK1YCL029CverifiedMicrotubule-associated protein, component of the interfacebetween microtubules and kinetochore, involvedin sister chromatid separation; essential inpolyploid cells but not in haploid or diploidcells; ortholog of mammalian CLIP-170 0.005220.14111&radic&radic&radic&radic&radic&radic S000003826ARP3YJR065CverifiedEssential component of the Arp2/3 complex, which is a highlyconserved actin nucleation center required forthe motility and integrity of actin patches;involved in endocytosis and membrane growth andpolarity 0.005210.14086 S000005991MUK1YPL070WuncharacterizedProtein of unknown function, localized to the cytoplasm;computational analysis of large-scaleprotein-protein interaction data suggests apossible role in transcriptional regulation 0.005190.14033&radic&radic&radic&radic&radic&radic&radic S000001699URA1YKL216WverifiedDihydroorotate dehydrogenase, catalyzes the fourth enzymaticstep in the de novo biosynthesis ofpyrimidines, converting dihydroorotic acid intoorotic acid 0.005190.14033&radic&radic&radic&radic&radic&radic&radic&radic S000004265SMD2YLR275WverifiedCore Sm protein Sm D2; part of heteroheptameric complex (withSmb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D2 0.00520.14033&radic&radic&radic&radic S000002483RAD55YDR076WverifiedProtein that stimulates strand exchange by stabilizing thebinding of Rad51p to single-stranded DNA;involved in the recombinational repair ofdouble-strand breaks in DNA during vegetativegrowth and meiosis; forms heterodimer withRad57p 0.00520.14033&radic&radic&radic&radic&radic&radic&radic S000001107RRP3YHR065CverifiedProtein involved in rRNA processing; required for maturation ofthe 35S primary transcript of pre-rRNA and forcleavage leading to mature 18S rRNA; homologousto eIF-4a, which is a DEAD box RNA-dependentATPase with helicase activity 0.005170.13968&radic&radic&radic&radic&radic&radic S000001512MAE1YKL029CverifiedMitochondrial malic enzyme, catalyzes the oxidativedecarboxylation of malate to pyruvate, which isa key intermediate in sugar metabolism and aprecursor for synthesis of several amino acids 0.005160.13915&radic&radic&radic&radic&radic S000005815YOR289WUncharacterizedHypothetical protein 0.005150.13915&radic&radic&radic&radic S000002728SWA2YDR320CverifiedAuxilin-like protein involved in vesicular transport;clathrin-binding protein required for uncoatingof clathrin-coated vesicles 0.005140.13907&radic&radic&radic&radic S000001789RPF2YKR081CverifiedEssential protein involved in the processing of pre-rRNA andthe assembly of the 60S ribosomal subunit;interacts with ribosomal protein L11; localizespredominantly to the nucleolus; constituent of66S pre-ribosomal particles 0.005140.13907&radic&radic&radic&radic&radic S000001530YKL047WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.005080.13718&radic&radic&radic&radic&radic&radic&radic&radic&radic S000001121IRE1YHR079CverifiedSerine-threonine kinase and endoribonuclease; transmembraneprotein that initiates the unfolded proteinresponse signal by regulating synthesis ofHac1p through HAC1 mRNA splicing 0.005130.13718&radic&radic&radic&radic S000005411GAL11YOL051WverifiedComponent of the Mediator complex; interacts with RNApolymerase II and the general transcriptionfactors to form the RNA polymerase IIholoenzyme; affects transcription by acting astarget of activators and repressors 0.005110.13718&radic&radic&radic S000004365VID22YLR373CverifiedGlycosylated integral membrane protein localized to the plasmamembrane; plays a role infructose-1,6-bisphosphatase (FBPase)degradation; involved in FBPase transport fromthe cytosol to Vid (vacuole import anddegradation) vesicles 0.005060.13667&radic&radic&radic&radic&radic S000004260DCS1YLR270WverifiedNon-essential hydrolase involved in mRNA decapping, mayfunction in a feedback mechanism to regulatedeadenylation, contains pyrophosphataseactivity and a HIT (histidine triad) motif;interacts with neutral trehalase Nth1p 0.005080.13667&radic&radic&radic&radic&radic S000003665TRK1YJL129CverifiedComponent of the Trk1p-Trk2p potassium transport system; 180kDa high affinity potassium transporter;phosphorylated in vivo and interacts physicallywith the phosphatase Ppz1p, suggesting Trk1pacitivy is regulated by phosphorylation 0.005040.13534&radic&radic&radic&radic&radic&radic S000006181YPL260WUncharacterizedHypothetical protein 0.005020.13534&radic&radic&radic&radic&radic S000001933RSC8YFR037CverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; essential for viability andmitotic growth; homolog of SWI/SNF subunitSwi3p, but unlike Swi3p, does not activatetranscription of reporters 0.005010.13511&radic&radic&radic S000004125SLX4YLR135WverifiedSubunit of a complex, with Slx1p, that hydrolyzes 5' branchesfrom duplex DNA in response to stalled orconverging replication forks; function overlapswith that of Sgs1p-Top3p 0.004990.13433&radic&radic&radic&radic&radic&radic S000003361SYF2YGR129WverifiedComponent of the spliceosome complex involved in pre-mRNAsplicing; involved in regulation of cell cycleprogression 0.004990.13433&radic&radic&radic&radic&radic S000005415PSH1YOL054WuncharacterizedNuclear protein, putative RNA polymerase II elongation factor;isolated as Pob3p/Spt16p-binding protein 0.0050.13433&radic&radic&radic&radic&radic S000003391NSR1YGR159CverifiedNucleolar protein that binds nuclear localization sequences,required for pre-rRNA processing and ribosomebiogenesis 0.004990.13433&radic&radic&radic&radic S000002687RNH202YDR279WverifiedRibonuclease H2 subunit, required for RNase H2 activity 0.004980.13433&radic&radic&radic&radic&radic&radic S000002134FUN19YAL034CverifiedNon-essential protein of unknown function 0.004980.13424&radic&radic&radic S000003279TFC4YGR047CverifiedOne of six subunits of the RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part of theTauA domain of TFIIIC that binds BoxA DNApromoter sites of tRNA and similar genes; hasTPR motifs; human homolog is TFIIIC-102 0.004980.13416&radic&radic&radic&radic&radic&radic S000001721PRY2YKR013WverifiedProtein of unknown function, has similarity to Pry1p and Pry3pand to the plant PR-1 class of pathogen relatedproteins 0.004970.13329&radic&radic&radic&radic&radic&radic&radic S000005552BUB3YOR026WverifiedKinetochore checkpoint WD40 repeat protein that localizes tokinetochores during prophase and metaphase,delays anaphase in the presence of unattachedkinetochores; forms complexes with Mad1p-Bub1pand with Cdc20p, binds Mad2p and Mad3p 0.004960.13329&radic&radic S000000735GCN4YEL009CverifiedTranscriptional activator of amino acid biosynthetic genes inresponse to amino acid starvation; expressionis tightly regulated at both thetranscriptional and translational levels 0.004960.13329&radic&radic&radic S000002571SEC1YDR164CverifiedSm-like protein involved in docking and fusion of exocyticvesicles through binding to assembled SNAREcomplexes at the membrane; localization tosites of secretion (bud neck and bud tip) isdependent on SNARE function 0.004960.13329&radic&radic&radic&radic&radic S000005890PIP2YOR363CverifiedAutoregulatory oleate-specific transcriptional activator ofperoxisome proliferation, contains Zn(2)-Cys(6)cluster domain, forms heterodimer with Oaf1p,binds oleate response elements (OREs),activates beta-oxidation genes 0.004950.13329&radic&radic&radic&radic&radic&radic S000004252YPT6YLR262CverifiedGTPase, Ras-like GTP binding protein involved in the secretorypathway, required for fusion ofendosome-derived vesicles with the late Golgi,maturation of the vacuolar carboxypeptidase Y;has similarity to the human GTPase, Rab6 0.004970.13329&radic&radic&radic&radic&radic S000004868GFD1YMR255WverifiedCoiled-coiled protein of unknown function, identified as ahigh-copy suppressor of a dbp5 mutation 0.004950.13329&radic&radic&radic&radic&radic&radic S000004789MMT1YMR177WverifiedPutative metal transporter involved in mitochondrial ironaccumulation; closely related to Mmt2p 0.004920.13197&radic&radic&radic S000002598RVB1YDR190CverifiedEssential protein involved in transcription regulation;component of chromatin remodeling complexes;required for assembly and function of the INO80complex; member of the RUVB-like protein family 0.00490.13197&radic&radic&radic S000004033TRX1YLR043CverifiedCytoplasmic thioredoxin isoenzyme of the thioredoxin systemwhich protects cells against both oxidative andreductive stress, forms LMA1 complex withPbi2p, acts as a cofactor for Tsa1p, requiredfor ER-Golgi transport and vacuole inheritance 0.004920.13197&radic&radic&radic&radic&radic S000005743RFC1YOR217WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon 0.004930.13197&radic&radic&radic&radic&radic S000001532CSE4YKL049CverifiedCentromere protein that resembles histones, required for properkinetochore function; homolog of human CENP-A 0.004920.13197&radic&radic&radic&radic&radic S000003949HSP104YLL026WverifiedHeat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p(Hsp70) to refold and reactivate previouslydenatured, aggregated proteins; responsive tostresses including: heat, ethanol, and sodiumarsenite; involved in [PSI+] propagation 0.004880.13141&radic&radic&radic&radic&radic&radic S000006010RLM1YPL089CverifiedMADS-box transcription factor, component of the protein kinaseC-mediated MAP kinase pathway involved in themaintenance of cell integrity; phosphorylatedand activated by the MAP-kinase Slt2p 0.004880.13141&radic&radic&radic&radic&radic S000001863HAC1YFL031WverifiedbZIP transcription factor (ATF/CREB1 homolog) that regulatesthe unfolded protein response, via UPREbinding, and membrane biogenesis; ERstress-induced splicing pathway utilizingIre1p, Trl1p and Ada5p facilitates efficientHac1p synthesis 0.004890.13141&radic&radic&radic&radic&radic&radic S000004267YSH1YLR277CverifiedPutative endonuclease, subunit of the mRNA cleavage andpolyadenylation specificity complex requiredfor 3' processing of mRNAs 0.004870.13122&radic&radic S000001873GAT1YFL021WverifiedTranscriptional activator of genes involved in nitrogencatabolite repression, member of the GATAfamily of DNA binding proteins; activity andlocalization regulated by nitrogen limitationand Ure2p 0.004840.12939&radic&radic&radic&radic&radic&radic&radic S000004641CCS1YMR038CverifiedCopper chaperone for superoxide dismutase Sod1p, involved inoxidative stress protection; Met-X-Cys-X2-Cysmotif within the N-terminal portion is involvedin insertion of copper into Sod1p underconditions of copper deprivation 0.004830.12939&radic&radic&radic&radic&radic&radic S000004490TSA1YML028WverifiedUbiquitous housekeeping thioredoxin peroxidase, reducesreactive oxygen, nitrogen and sulfur speciesusing thioredoxin as hydrogen donor; mediatesredox regulation of the nuclear localization ofYap1p; deletion results in mutator phenotype 0.004820.12939&radic&radic&radic&radic&radic&radic S000001672HYM1YKL189WverifiedComponent of the RAM signaling network that is involved inregulation of Ace2p activity and cellularmorphogenesis, interacts with Kic1p and Sog2p,localizes to sites of polarized growth duringbudding and during the mating response 0.004840.12939&radic&radic&radic&radic&radic&radic&radic S000005127NPR1YNL183CverifiedProtein kinase that stabilizes several plasma membrane aminoacid transporters by antagonizing theirubiquitin-mediated degradation 0.004830.12939&radic&radic&radic&radic&radic&radic&radic&radic S000003723SWE1YJL187CverifiedProtein kinase that regulates the G2/M transition by inhibitionof Cdc28p kinase activity; localizes to thenucleus and to the daughter side of themother-bud neck; homolog of S. pombe Wee1p;potential Cdc28p substrate 0.004820.12939&radic&radic&radic&radic S000000777VMA8YEL051WverifiedSubunit D of the eight-subunit V1 peripheral membrane domain ofthe vacuolar H+-ATPase (V-ATPase), anelectrogenic proton pump found throughout theendomembrane system; plays a role in thecoupling of proton transport and ATP hydrolysis 0.00480.12911&radic&radic&radic&radic&radic&radic S000000861PCL6YER059WverifiedPho85p cyclin of the Pho80p subfamily; forms the major Glc8pkinase together with Pcl7p and Pho85p; involvedin the control of glycogen storage by Pho85p;stabilized by Elongin C binding 0.004790.12855&radic&radic&radic&radic&radic&radic&radic&radic&radic S000002621UPC2YDR213WverifiedSterol regulatory element binding protein, inducestranscription of sterol transport andbiosynthetic genes; involved in the anaerobicinduction of DAN/TIR mannoproteins andseripauperins; binucleate zinc cluster protein;Ecm22p homolog 0.004790.12855&radic&radic&radic S000004172SWI6YLR182WverifiedTranscription cofactor, forms complexes with DNA-bindingproteins Swi4p and Mbp1p to regulatetranscription at the G1/S transition; involvedin meiotic gene expression; localizationregulated by phosphorylation; potential Cdc28psubstrate 0.004790.12855&radic&radic&radic&radic S000006366ORC4YPR162CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing 0.004790.12855&radic&radic&radic&radic S000001282HIS6YIL020CverifiedPhosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamideisomerase, catalyzes the fourth step inhistidine biosynthesis; mutations causehistidine auxotrophy and sensitivity to Cu, Co,and Ni salts 0.004750.12744&radic&radic&radic&radic&radic&radic&radic S000002565HOM2YDR158WverifiedAspartic beta semi-aldehyde dehydrogenase, catalyzes the secondstep in the common pathway for methionine andthreonine biosynthesis; expression regulated byGcn4p and the general control of amino acidsynthesis 0.004750.12744&radic&radic&radic&radic&radic&radic&radic S000001911GSY1YFR015CverifiedGlycogen synthase with similarity to Gsy2p, the more highlyexpressed yeast homolog; expression induced byglucose limitation, nitrogen starvation,environmental stress, and entry into stationaryphase 0.004740.12744&radic&radic&radic&radic&radic S000001667SPE1YKL184WverifiedOrnithine decarboxylase, catalyzes the first step in polyaminebiosynthesis; degraded in aproteasome-dependent manner in the presence ofexcess polyamines 0.004740.12735&radic&radic&radic&radic&radic S000000605PGK1YCR012Wverified3-phosphoglycerate kinase, catalyzes transfer of high-energyphosphoryl groups from the acyl phosphate of1,3-bisphosphoglycerate to ADP to produce ATP;key enzyme in glycolysis and gluconeogenesis 0.004730.12665&radic&radic&radic&radic&radic&radic S000003330ESP1YGR098CverifiedSeparase with cysteine protease activity (related to caspases)that promotes sister chromatid separation bymediating dissociation of the cohesin Scc1pfrom chromatin; inhibited by Pds1p 0.004730.12665&radic&radic&radic&radic&radic&radic S000005928TFC8YPL007CverifiedOne of six subunits of RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part ofTFIIIC TauB domain that binds BoxB promotersites of tRNA and other genes; linker betweenTauB and TauA domains; human homolog isTFIIIC-90 0.004690.12576&radic&radic&radic&radic&radic&radic S000004342ORM2YLR350WverifiedEvolutionarily conserved protein with similarity to Orm1p,required for resistance to agents that inducethe unfolded protein response; human orthologis located in the endoplasmic reticulum 0.004690.12515&radic&radic&radic&radic S000006005BRO1YPL084WverifiedCytoplasmic class E vacuolar protein sorting (VPS) factor thatcoordinates deubiquitination in themultivesicular body (MVB) pathway by recruitingDoa4p to endosomes 0.004670.12474&radic&radic&radic&radic&radic&radic&radic&radic S000002265MSS2YDL107WverifiedPeripherally bound inner membrane protein of the mitochondrialmatrix, required for export of C-terminal tailof Cox2p through the inner membrane 0.004660.12474 S000003641SET4YJL105WverifiedProtein of unknown function, contains a SET domain 0.004660.12474 S000005756WTM1YOR230WverifiedTranscriptional repressor involved in regulation of meiosis andsilencing; contains WD repeats 0.004660.12474&radic&radic&radic&radic&radic S000005369MDM12YOL009CverifiedMitochondrial outer membrane protein, required for transmissionof mitochondria to daughter cells; exists in acomplex with Mmm1p and Mdm10p 0.004650.12465&radic&radic&radic&radic&radic&radic&radic&radic S000006111NAB3YPL190CverifiedSingle stranded DNA binding protein; acidic ribonucleoprotein;required for termination of non-poly(A)transcripts and efficient splicing; interactswith Nrd1p 0.004640.12381&radic&radic&radic&radic&radic&radic&radic S000002880TRS31YDR472WverifiedOne of 10 subunits of the transport protein particle (TRAPP)complex of the cis-Golgi which mediates vesicledocking and fusion; involved in endoplasmicreticulum (ER) to Golgi membrane traffic 0.004630.12381 S000002748YDR340WDubiousPutative protein of unknown function 0.004630.12381&radic&radic S000004530ORC1YML065WverifiedLargest subunit of the origin recognition complex, whichdirects DNA replication by binding toreplication origins and is also involved intranscriptional silencing; may bephosphorylated by Cdc28p 0.004640.12381 S000004755YMR147WUncharacterizedHypothetical protein 0.004620.1232&radic&radic&radic&radic&radic&radic&radic S000006074RAD53YPL153CverifiedProtein kinase, required for cell-cycle arrest in response toDNA damage; activated by transautophosphorylation when interacting withhyperphosphorylated Rad9p; also interacts withARS1 and plays a role in initiation of DNAreplication 0.00460.12299&radic&radic&radic&radic S000002973COG7YGL005CverifiedComponent of the conserved oligomeric Golgi complex (Cog1pthrough Cog8p), a cytosolic tethering complexthat functions in protein trafficking tomediate fusion of transport vesicles to Golgicompartments 0.00460.12299&radic&radic&radic&radic S000000832CHZ1YER030WuncharacterizedPutative chaperone for Htz1p/H2A-H2B dimer 0.004590.12251&radic&radic&radic&radic&radic S000001054VPS29YHR012WverifiedEndosomal protein that is a subunit of the membrane-associatedretromer complex essential forendosome-to-Golgi retrograde transport; forms asubcomplex with Vps35p and Vps26p that selectscargo proteins for endosome-to-Golgi retrieval 0.00460.12251&radic&radic&radic&radic&radic&radic&radic S000005584ASE1YOR058CverifiedMember of a family of microtubule-associated proteins (MAPs)that function at the mitotic spindle midzone;required for spindle elongation; undergoes cellcycle-regulated degradation by anaphasepromoting complex; potential Cdc28p substrate 0.004570.12201&radic&radic&radic&radic S000001493UFD4YKL010CverifiedUbiquitin-protein ligase (E3) that interacts with Rpt4p andRpt6p, two subunits of the 19S particle of the26S proteasome; cytoplasmic E3 involved in thedegradation of ubiquitin fusion proteins 0.004580.12201&radic&radic&radic&radic&radic&radic S000000115APN2YBL019WverifiedClass II abasic (AP) endonuclease involved in repair of DNAdamage; homolog of human HAP1 and E. coliexoIII 0.004550.12105&radic&radic&radic&radic&radic&radic&radic S000005215BNI1YNL271CverifiedFormin, nucleates the formation of linear actin filaments,involved in cell processes such as budding andmitotic spindle orientation which require theformation of polarized actin cables,functionally redundant with BNR1 0.004540.12063&radic&radic&radic&radic S000006125HRR25YPL204WverifiedProtein kinase involved in regulating diverse events includingvesicular trafficking, gene expression, DNArepair, and chromosome segregation; binds theCTD of RNA pol II; homolog of mammalian caseinkinase 1delta (CK1delta) 0.004530.12063&radic&radic&radic S000005234RFC3YNL290WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon 0.004540.12063&radic&radic&radic&radic S000004166RFX1YLR176CverifiedProtein involved in DNA damage and replication checkpointpathway; recruits repressors Tup1p and Cyc8p topromoters of DNA damage-inducible genes;similar to a family of mammalian DNA bindingRFX1-4 proteins 0.004520.12004&radic&radic S000004093CDC45YLR103CverifiedDNA replication initiation factor; recruited to MCM pre-RCcomplexes at replication origins; promotesrelease of MCM from Mcm10p, recruits elongationmachinery; mutants in human homolog may causevelocardiofacial and DiGeorge syndromes 0.004520.12004&radic&radic&radic&radic S000000098HTB2YBL002WverifiedOne of two nearly identical (see HTB1) histone H2B subtypesrequired for chromatin assembly and chromosomefunction; Rad6p-Bre1p-Lge1p mediatedubiquitination regulates transcriptionalactivation, meiotic DSB formation and H3methylation 0.004510.11865&radic&radic&radic&radic&radic&radic S000000004SSA1YAL005CverifiedATPase involved in protein folding and nuclear localizationsignal (NLS)-directed nuclear transport; memberof heat shock protein 70 (HSP70) family; formsa chaperone complex with Ydj1p; localized tothe nucleus, cytoplasm, and cell wall 0.004480.11865&radic&radic S000005428RTG1YOL067CverifiedTranscription factor (bHLH) involved in interorganellecommunication between mitochondria,peroxisomes, and nucleus 0.004480.11865&radic&radic&radic&radic&radic&radic&radic S000004198SEC13YLR208WverifiedComponent of both the Nup84 nuclear pore sub-complex and of theCOPII complex (Sar1p, Sec13p, Sec16p, Sec23p,Sec24p, Sec31p, Sfb2p, and Sfb3p) which isimportant for the formation of ER to Golgitransport vesicles 0.00450.11865&radic&radic&radic&radic S000005004ARP5YNL059CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes 0.00450.11865 S000005403NTG2YOL043CverifiedDNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involvedin base excision repair, localizes to thenucleus 0.004460.11776&radic&radic&radic&radic S000002528DPB4YDR121WverifiedShared subunit of DNA polymerase epsilon and of ISW2/yCHRACchromatin accessibility complex; involved inboth chromosomal DNA replication and ininheritance of telomeric silencing 0.004440.11754&radic&radic&radic S000000187MAP2YBL091CverifiedMethionine aminopeptidase, catalyzes the cotranslationalremoval of N-terminal methionine from nascentpolypeptides; function is partially redundantwith that of Map1p 0.004430.11721&radic&radic&radic&radic&radic&radic&radic S000005816SNF2YOR290CverifiedCatalytic subunit of the SWI/SNF chromatin remodeling complexinvolved in transcriptional regulation;contains DNA-stimulated ATPase activity;functions interdependently in transcriptionalactivation with Snf5p and Snf6p 0.004430.11721&radic&radic S000000019CCR4YAL021CverifiedComponent of the CCR4-NOT transcriptional complex, which isinvolved in regulation of gene expression;component of the major cytoplasmic deadenylase,which is involved in mRNA poly(A) tailshortening 0.004440.11721&radic&radic&radic&radic S000000427TDP1YBR223CverifiedTyrosyl-DNA Phosphodiesterase I, hydrolyzes 3'-phosphotyrosylbonds to generate 3'-phosphate DNA andtyrosine, involved in the repair of DNA lesionscreated by topoisomerase I 0.004430.11721&radic&radic&radic&radic S000001666LOT5YKL183WverifiedProtein of unknown function; gene expression increases incultures shifted to a lower temperature 0.004430.11721&radic&radic&radic&radic S000001751YKR043CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 0.004410.11665&radic&radic&radic&radic S000006049TBF1YPL128CverifiedTelobox-containing general regulatory factor; binds to TTAGGGrepeats within subtelomeric anti-silencingregions (STARs) and possibly throughout thegenome and mediates their insulating capacityby blocking silent chromatin propagation 0.004410.11652&radic&radic S000002672AKR1YDR264CverifiedPalmitoyl transferase involved in protein palmitoylation; actsas a negative regulator of pheromone responsepathway; required for endocytosis of pheromonereceptors; involved in cell shape control;contains ankyrin repeats 0.00440.116&radic&radic S000001082BCD1YHR040WverifiedEssential protein required for the accumulation of box C/DsnoRNA 0.004390.116&radic&radic&radic&radic&radic S000005992YPL071CUncharacterizedHypothetical protein 0.004390.11546&radic&radic&radic&radic&radic S000001782YKR074WUncharacterizedPutative protein of unknown function; epitope-tagged protein localizes to the cytoplasm 0.004390.11546&radic&radic&radic S000001334HOP1YIL072WverifiedMeiosis-specific DNA binding protein that displays Red1pdependent localization to the unsynapsedaxial-lateral elements of the synaptonemalcomplex; required for homologous chromosomesynapsis and chiasma formation 0.004390.11546&radic&radic&radic&radic&radic&radic&radic&radic S000005532YOR006CUncharacterizedHypothetical protein 0.004380.11546&radic&radic&radic&radic&radic S000005835SNU66YOR308CverifiedComponent of the U4/U6.U5 snRNP complex involved in pre-mRNAsplicing via spliceosome; has homology to humanSART-1 and to an S. pombe protein; snu66 nullmutation confers cold-sensitivity but is notlethal at normal growth temperatures 0.004390.11546&radic&radic&radic&radic S000000818BIM1YER016WverifiedMicrotubule-binding protein that together with Kar9p makes upthe cortical microtubule capture site anddelays the exit from mitosis when the spindleis oriented abnormally 0.004370.11524&radic&radic&radic&radic&radic S000000772GLY1YEL046CverifiedThreonine aldolase, catalyzes the cleavage of L-allo-threonineand L-threonine to glycine; involved in glycinebiosynthesis 0.004350.11417&radic&radic&radic&radic S000005399RPP2AYOL039WverifiedRibosomal protein P2 alpha, a component of the ribosomal stalk,which is involved in the interaction betweentranslational elongation factors and theribosome; regulates the accumulation of P1(Rpp1Ap and Rpp1Bp) in the cytoplasm 0.004350.11417&radic&radic&radic&radic&radic&radic&radic S000004297UBC12YLR306WverifiedEnzyme that mediates the conjugation of Rub1p, a ubiquitin-likeprotein, to other proteins; related to E2ubiquitin-conjugating enzymes 0.004360.11417&radic&radic&radic&radic S000003618IML2YJL082WverifiedProtein of unknown function; the authentic, non-tagged proteinis detected in highly purified mitochondria inhigh-throughput studies 0.004350.11417 S000006345KAR3YPR141CverifiedMinus-end-directed microtubule motor that functions in mitosisand meiosis, localizes to the spindle pole bodyand localization is dependent on functionalCik1p, required for nuclear fusion duringmating; potential Cdc28p substrate 0.004340.11417&radic&radic&radic S000006077PRM4YPL156CverifiedPheromone-regulated protein, predicted to have 1 transmembranesegment; transcriptionally regulated by Ste12pduring mating and by Cat8p during the diauxicshift 0.004340.11417&radic&radic&radic&radic&radic S000005775APC5YOR249CverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 0.004350.11417&radic&radic&radic&radic S000006339CTF4YPR135WverifiedChromatin-associated protein, required for sister chromatidcohesion; interacts with DNA polymerase alpha(Pol1p) and may link DNA synthesis to sisterchromatid cohesion 0.004350.11417&radic&radic&radic S000003099SNT2YGL131CverifiedDNA binding protein with similarity to the S. pombe Snt2protein 0.004320.11313 S000005133SRP1YNL189WverifiedKaryopherin alpha homolog, forms a dimer with karyopherin betaKap95p to mediate import of nuclear proteins,binds the nuclear localization signal of thesubstrate during import; may also play a rolein regulation of protein degradation 0.00430.11311&radic&radic&radic S000001492MRT4YKL009WverifiedProtein involved in mRNA turnover and ribosome assembly,localizes to the nucleolus 0.00430.1131&radic&radic&radic&radic&radic S000001381RPI1YIL119CverifiedPutative transcriptional regulator; overexpression suppressesthe heat shock sensitivity of wild-type RAS2overexpression and also suppresses the celllysis defect of an mpk1 mutation 0.00430.113 S000000078PRM9YAR031WverifiedPheromone-regulated protein with 3 predicted transmembranesegments and an FF sequence, a motif involvedin COPII binding; member of DUP240 gene family 0.004290.11219&radic&radic&radic&radic&radic&radic&radic&radic S000004107CLF1YLR117CverifiedEssential splicesome assembly factor; contains multipletetratricopeptide repeat (TPR) protein-bindingmotifs and interacts specifically with manyspliceosome components, may serve as a scaffoldduring splicesome assembly 0.004280.11219&radic&radic&radic&radic&radic&radic S000000046GEM1YAL048CverifiedEvolutionarily-conserved tail-anchored outer mitochondrialmembrane GTPase which regulates mitochondrialmorphology; cells lacking Gem1p containcollapsed, globular, or grape-likemitochondria; not required forpheromone-induced cell death 0.004280.11219&radic&radic&radic&radic&radic&radic S000004647IOC4YMR044WverifiedMember of a complex (Isw1b) with Isw1p and Ioc2p that exhibitsnucleosome-stimulated ATPase activity and actswithin coding regions to coordinatetranscription elongation with termination andprocessing, contains a PWWP motif 0.004250.11127&radic&radic&radic S000001474YIR035CUncharacterizedHypothetical protein 0.004260.11127&radic&radic&radic&radic S000000598CIT2YCR005CverifiedCitrate synthase, catalyzes the condensation of acetyl coenzymeA and oxaloacetate to form citrate, peroxisomalisozyme involved in glyoxylate cycle;expression is controlled by Rtg1p and Rtg2ptranscription factors 0.004240.11091&radic&radic&radic&radic&radic S000002490RRP8YDR083WverifiedNucleolar protein involved in rRNA processing, pre-rRNAcleavage at site A2; also involved in telomeremaintenance; mutation is synthetically lethalwith a gar1 mutation 0.004230.11016&radic&radic&radic S000001611PMU1YKL128CverifiedPutative phosphomutase, contains a region homologous to theactive site of phsophomutases; overexpressionof the gene suppresses the histidine auxotrophyof an ade3 ade16 ade17 triple mutant and thetemperature sensitivity of a tps2 mutant 0.004210.10971&radic&radic&radic&radic&radic&radic&radic S000005659EFT1YOR133WverifiedElongation factor 2 (EF-2), also encoded by EFT2; catalyzesribosomal translocation during proteinsynthesis; contains diphthamide, the uniqueposttranslationally modified histidine residuespecifically ADP-ribosylated by diphtheriatoxin 0.00420.10971&radic&radic&radic&radic&radic S000003502YTA7YGR270WverifiedProtein of unknown function, member of CDC48/PAS1/SEC18 familyof ATPases, potentially phosphorylated byCdc28p 0.004210.10971&radic&radic&radic S000002738UBX5YDR330WuncharacterizedUBX (ubiquitin regulatory X) domain-containing protein thatinteracts with Cdc48p 0.00420.10936&radic&radic&radic&radic S000001518UGP1YKL035WverifiedUDP-glucose pyrophosphorylase (UGPase), catalyses thereversible formation of UDP-Glc from glucose1-phosphate and UTP, involved in a wide varietyof metabolic pathways, expression modulated byPho85p through Pho4p 0.004190.10936&radic&radic&radic&radic&radic&radic&radic&radic&radic S000000097ECM15YBL001CverifiedNon-essential protein of unknown function, likely exists astetramer, may be regulated by the binding ofsmall-molecule ligands (possibly sulfate ions),may have a role in yeast cell-wall biogenesis 0.004180.10908&radic&radic&radic&radic&radic&radic S000003466YHB1YGR234WverifiedNitric oxide oxidoreductase, flavohemoglobin involved in nitricoxide detoxification; plays a role in theoxidative and nitrosative stress responses 0.004190.10908&radic&radic&radic S000002506BMH2YDR099Wverified14-3-3 protein, minor isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others 0.004170.1088&radic&radic&radic S000005590YNG1YOR064CverifiedSubunit of the NuA3 histone acetyltransferase complex thatacetylates histone H3; has similarity to thehuman tumor suppressor ING1 &radic0.004160.1085&radic&radic&radic S000002948IRC4YDR540CuncharacterizedHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 0.004170.1085&radic&radic&radic&radic&radic S000005988YPL067CUncharacterizedHypothetical protein 0.004160.1085&radic&radic&radic&radic&radic&radic S000004279MEC3YLR288CverifiedDNA damage and meiotic pachytene checkpoint protein; subunit ofa heterotrimeric complex (Rad17p-Mec3p-Ddc1p)that forms a sliding clamp, loaded onto partialduplex DNA by a clamp loader complex; homologof human and S. pombe Hus1 0.004140.10771&radic&radic&radic S000002904PUF6YDR496CverifiedPumilio-homology domain protein that binds ASH1 mRNA at PUFconsensus sequences in the 3' UTR and repressesits translation, resulting in proper asymmetriclocalization of ASH1 mRNA 0.004130.10771 S000000030PRP45YAL032CverifiedProtein required for pre-mRNA splicing; associates with thespliceosome and interacts with splicing factorsPrp22p and Prp46p; orthologous to humantranscriptional coactivator SKIP and canactivate transcription of a reporter gene 0.004120.1072&radic&radic&radic&radic&radic&radic S000002637IVY1YDR229WverifiedPhospholipid-binding protein that interacts with both Ypt7p andVps33p, may partially counteract the action ofVps33p and vice versa, localizes to the rim ofthe vacuole as cells approach stationary phase 0.004110.10614&radic&radic&radic&radic&radic S000004140STM1YLR150WverifiedProtein that binds G4 quadruplex and purine motif triplexnucleic acid; acts with Cdc13p to maintaintelomere structure; interacts with ribosomesand subtelomeric Y' DNA; multicopy suppressorof tom1 and pop2 mutations 0.004110.10614&radic&radic&radic S000001028MUP3YHL036WverifiedLow affinity methionine permease, similar to Mup1p 0.00410.10614&radic&radic S000001525SPC42YKL042WverifiedCentral plaque component of spindle pole body (SPB); involvedin SPB duplication, may facilitate attachmentof the SPB to the nuclear membrane 0.004110.10614&radic&radic S000003315GCD2YGR083CverifiedDelta subunit of the translation initiation factor eIF2B, theguanine-nucleotide exchange factor for eIF2;activity subsequently regulated byphosphorylated eIF2; first identified as anegative regulator of GCN4 expression 0.004090.10614&radic&radic&radic&radic&radic&radic S000001557MUD2YKL074CverifiedProtein involved in early pre-mRNA splicing; component of thepre-mRNA-U1 snRNP complex, the commitmentcomplex; interacts with Msl5p/BBP splicingfactor and Sub2p; similar to metazoan splicingfactor U2AF65 0.004110.10614&radic&radic&radic S000002608VPS64YDR200CverifiedCytoplasmic protein required for cytoplasm to vacuole targetingof proteins; forms a complex with Far3p, Far7p,Far10p, and Far11p that is involved inpheromone-induced cell cycle arrest; alsolocalized to the endoplasmic reticulum membrane 0.004090.10614&radic&radic&radic&radic&radic&radic S000006119RPL7BYPL198WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl7Ap and has similarity to E.coli L30 and rat L7 ribosomal proteins;contains a conserved C-terminal Nucleic acidBinding Domain (NDB2) 0.004090.10614&radic&radic&radic&radic S000001210THP2YHR167WverifiedSubunit of the THO complex, which connects transcriptionelongation and mitotic recombination, and ofthe TREX complex, which is recruited toactivated genes and couples transcription tomRNA export; involved in telomere maintenance 0.004090.10614&radic&radic&radic&radic S000001673CNB1YKL190WverifiedCalcineurin B; the regulatory subunit of calcineurin, aCa++/calmodulin-regulated protein phosphatasewhich regulates Crz1p (a stress-responsetranscription factor), the other calcineurinsubunit is encoded by CNA1 and/or CMP1 0.004110.10614&radic&radic&radic&radic&radic&radic&radic S000003259RPS25AYGR027CverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps25Bp and has similarity to ratS25 ribosomal protein 0.004090.10614&radic&radic&radic&radic S000005755WTM2YOR229WverifiedTranscriptional repressor involved in regulation of meiosis andsilencing; contains WD repeats 0.004090.10608&radic&radic&radic&radic&radic&radic&radic S000006314RPC40YPR110CverifiedRNA polymerase subunit, common to RNA polymerase I and III 0.004080.10569&radic&radic&radic&radic S000006044RNY1YPL123CverifiedRNAse; member of the T(2) family of endoribonucleases 0.004080.10569&radic&radic&radic&radic&radic S000005885HAP5YOR358WverifiedSubunit of the heme-activated, glucose-repressed Hap2/3/4/5CCAAT-binding complex, a transcriptionalactivator and global regulator of respiratorygene expression; required for assembly and DNAbinding activity of the complex 0.004080.10569&radic&radic&radic S000003193VRG4YGL225WverifiedGolgi GDP-mannose transporter; regulates Golgi function andglycosylation in Golgi 0.004060.10507&radic&radic&radic&radic S000004163YLR173WUncharacterizedHypothetical protein 0.004050.10507&radic&radic S000001221STB5YHR178WverifiedActivator of multidrug resistance genes, forms a heterodimerwith Pdr1p; contains a Zn(II)2Cys6 zinc fingerdomain that interacts with a PDRE (pleotropicdrug resistance element) in vitro; binds Sin3pin a two-hybrid assay 0.004050.10489&radic&radic&radic&radic&radic&radic S000001197RTT107YHR154WverifiedProtein implicated in Mms22-dependent DNA repair during Sphase, DNA damage induces phosphorylation byMec1p at one or more SQ/TQ motifs; interactswith Mms22p and Slx4p; has four BRCT domains;has a role in regulation of Ty1 transposition 0.004050.10489&radic&radic&radic&radic&radic S000001913YFR017CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR017C is not an essential gene 0.004040.10459&radic&radic&radic&radic&radic&radic&radic&radic S000000060YAL064WUncharacterizedHypothetical protein 0.004050.10459 S000001643ELF1YKL160WverifiedTranscription elongation factor that contains a conserved zincfinger domain; implicated in the maintenance ofproper chromatin structure in activelytranscribed regions; deletion inhibits Bromemosaic virus (BMV) gene expression 0.004050.10459&radic&radic&radic&radic&radic&radic S000001291YIL029CUncharacterizedPutative protein of unknown function 0.004050.10459&radic&radic&radic&radic&radic S000000103SLA1YBL007CverifiedCytoskeletal protein binding protein required for assembly ofthe cortical actin cytoskeleton; contains 3 SH3domains; interacts with proteins regulatingactin dynamics and with proteins required forendocytosis 0.004030.10402&radic&radic&radic&radic&radic&radic S000004642SUB1YMR039CverifiedTranscriptional coactivator, facilitates elongation byinfluencing enzymes that modify RNAP II, actsin a peroxide resistance pathway involvingRad2p; suppressor of TFIIB mutations 0.004030.10402&radic&radic&radic&radic S000003449CCH1YGR217WverifiedVoltage-gated high-affinity calcium channel involved in calciuminflux in response to some environmentalstresses as well as exposure to matingpheromones; interacts and co-localizes withMid1p, suggesting Cch1p and Mid1p functiontogether 0.004010.10321&radic&radic&radic&radic&radic&radic&radic S000005947SKS1YPL026CverifiedPutative serine/threonine protein kinase; involved in theadaptation to low concentrations of glucoseindependent of the SNF3 regulated pathway 0.004020.10321&radic&radic&radic&radic&radic&radic S000004639MIH1YMR036CverifiedProtein tyrosine phosphatase involved in cell cycle control;regulates the phosphorylation state of Cdc28p;homolog of S. pombe cdc25 0.004010.10321&radic&radic&radic&radic&radic&radic&radic S000000075UIP3YAR027WverifiedPutative integral membrane protein of unknown function;interacts with Ulp1p at the nuclear periphery;member of DUP240 gene family 0.003990.10304&radic&radic&radic&radic&radic&radic S000003927ORC3YLL004WverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing 0.003990.10219&radic&radic&radic&radic&radic S000005923SNF8YPL002CverifiedComponent of the ESCRT-II complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; appears to be functionallyrelated to SNF7; involved in glucosederepression 0.003970.10181&radic&radic&radic S000003921MPH3YJR160CverifiedAlpha-glucoside permease, transports maltose, maltotriose,alpha-methylglucoside, and turanose; identicalto Mph2p; encoded in a subtelomeric position ina region likely to have undergone duplication 0.003970.10181 S000001226GND1YHR183Wverified6-phosphogluconate dehydrogenase (decarboxylating), catalyzesan NADPH regenerating reaction in the pentosephosphate pathway; required for growth onD-glucono-delta-lactone and adaptation tooxidative stress 0.003970.10181&radic&radic&radic S000002837TIF35YDR429CverifiedSubunit of the core complex of translation initiation factor3(eIF3), which is essential for translation 0.003960.10181&radic&radic&radic&radic&radic&radic S000006185YPL264CUncharacterizedHypothetical protein 0.003960.10181&radic&radic&radic&radic&radic&radic&radic S000001038PAU13YHL046CuncharacterizedPutative protein of unknown function; not an essential gene 0.003940.10036&radic&radic&radic&radic&radic S000003013RIM8YGL045WverifiedProtein of unknown function, involved in the proteolyticactivation of Rim101p in response to alkalinepH; has similarity to A. nidulans PalF 0.003940.10036&radic&radic&radic&radic&radic S000003510CWC22YGR278WverifiedEssential protein, component of a complex containing Cef1p, hassimilarity to S. pombe Cwf22p; putativespliceosomal component, based on computationalanalysis of large-scale protein-proteininteraction data 0.003930.10036&radic&radic&radic&radic S000000111ACH1YBL015WverifiedAcetyl-coA hydrolase, primarily localized to mitochondria;required for acetate utilization and fordiploid pseudohyphal growth 0.003920.10036&radic&radic&radic&radic&radic S000005771DGA1YOR245CverifiedDiacylglycerol acyltransferase, catalyzes the terminal step oftriacylglycerol (TAG) formation, acylatesdiacylglycerol using acyl-CoA as an acyl donor,localized to lipid particles 0.003950.10036&radic&radic&radic S000000980PDA1YER178WverifiedE1 alpha subunit of the pyruvate dehydrogenase (PDH) complex,catalyzes the direct oxidative decarboxylationof pyruvate to acetyl-CoA, regulated by glucose 0.003950.10036 S000003389CHO2YGR157WverifiedPhosphatidylethanolamine methyltransferase (PEMT), catalyzesthe first step in the conversion ofphosphatidylethanolamine to phosphatidylcholineduring the methylation pathway ofphosphatidylcholine biosynthesis 0.003960.10036&radic&radic&radic&radic&radic&radic S000005440REX4YOL080CverifiedPutative RNA exonuclease possibly involved in pre-rRNAprocessing and ribosome assembly 0.003920.10029&radic&radic&radic&radic&radic S000005242CLA4YNL298WverifiedCdc42p activated signal transducing kinase of the PAK(p21-activated kinase) family, involved inseptin ring assembly and cytokinesis; directlyphosphorylates septins Cdc3p and Cdc10p; otheryeast PAK family members are Ste20p and Skm1p 0.003920.09928&radic&radic&radic&radic S000002723IPK1YDR315CverifiedInositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear proteinrequired for synthesis of1,2,3,4,5,6-hexakisphosphate (phytate), whichis integral to cell function; has 2 motifsconserved in other fungi; ipk1 gle1 doublemutant is inviable 0.003910.09928&radic&radic&radic&radic&radic S000004780ALD2YMR170CverifiedCytoplasmic aldehyde dehydrogenase, involved in ethanoloxidation and beta-alanine biosynthesis; usesNAD+ as the preferred coenzyme; expression isstress induced and glucose repressed; verysimilar to Ald3p 0.003910.09928&radic&radic&radic&radic S000001500HCS1YKL017CverifiedHexameric DNA polymerase alpha-associated DNA helicase Ainvolved in lagging strand DNA synthesis;contains single-stranded DNA stimulated ATPaseand dATPase activities; replication protein Astimulates helicase and ATPase activities 0.00390.09928&radic&radic&radic&radic&radic S000003340CLB1YGR108WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the transition from G2 to Mphase; accumulates during G2 and M, thentargeted via a destruction box motif forubiquitin-mediated degradation by theproteasome 0.003890.09921&radic&radic&radic&radic S000003692SSY5YJL156CverifiedProbable serine protease of the SPS plasma membrane amino acidsensor system (Ssy1p-Ptr3p-Ssy5p), which sensesexternal amino acid concentration and transmitsintracellular signals that regulate expressionof amino acid permease genes 0.003880.09869&radic&radic&radic&radic&radic S000006169GAL4YPL248CverifiedDNA-binding transcription factor required for the activation ofthe GAL genes in response to galactose;repressed by Gal80p and activated by Gal3p 0.003880.09869&radic&radic&radic S000005258DAL82YNL314WverifiedPositive regulator of allophanate inducible genes; binds adodecanucleotide sequence upstream of all genesthat are induced by allophanate; contains anUISALL DNA-binding, a transcriptionalactivation, and a coiled-coil domain 0.003880.09869&radic&radic&radic&radic S000003730CDC6YJL194WverifiedEssential ATP-binding protein required for DNA replication,component of the pre-replicative complex(pre-RC) which requires ORC to associate withchromatin and is in turn required for Mcm2-7pDNA association; homologous to S. pombe Cdc18p 0.003880.09869&radic&radic&radic&radic&radic S000006209HAL1YPR005CverifiedCytoplasmic protein involved in halotolerance; decreasesintracellular Na+ (via Ena1p) and increasesintracellular K+ by decreasing efflux;expression repressed by Ssn6p-Tup1p and Sko1pand induced by NaCl, KCl, and sorbitol throughGcn4p 0.003880.09869&radic&radic&radic&radic&radic&radic S000005603RTS2YOR077WverifiedBasic zinc-finger protein, similar to human and mouse Kin17proteins which are chromatin-associatedproteins involved in UV response and DNAreplication 0.003870.09836&radic&radic&radic&radic&radic S000002673PEX10YDR265WverifiedRING finger peroxisomal membrane peroxin required forperoxisomal matrix protein import, interactswith Pex12p, links ubiquitin-conjugating Pex4pto protein import machinery; mutations in humanhomolog cause a variety of peroxisomaldisorders 0.003870.09836&radic&radic&radic&radic&radic S000002655VHS1YDR247WverifiedCytoplasmic serine/threonine protein kinase; identified as ahigh-copy suppressor of the synthetic lethalityof a sis2 sit4 double mutant, suggesting a rolein G1/S phase progression; homolog of Sks1p 0.003860.09707&radic&radic&radic&radic S000001901SAD1YFR005CverifiedConserved zinc-finger domain protein involved in pre-mRNAsplicing, required for assembly of U4 snRNAinto the U4/U6 particle 0.003850.09707&radic&radic&radic&radic S000002802RPT3YDR394WverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; substrate ofN-acetyltransferase B 0.003860.09707&radic&radic S000001315RHR2YIL053WverifiedConstitutively expressed isoform of DL-glycerol-3-phosphatase;involved in glycerol biosynthesis, induced inresponse to both anaerobic and, along with theHor2p/Gpp2p isoform, osmotic stress 0.003840.09707&radic&radic&radic&radic&radic S000000013NTG1YAL015CverifiedDNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involvedin base excision repair, localizes to thenucleus and mitochondrion 0.003860.09707&radic&radic&radic&radic&radic&radic S000000873YER071CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.003840.09707&radic&radic&radic&radic&radic&radic&radic S000001554YKL071WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.003860.09707&radic&radic&radic&radic&radic&radic&radic&radic S000004175RPL37AYLR185WverifiedProtein component of the large (60S) ribosomal subunit, hassimilarity to Rpl37Bp and to rat L37 ribosomalprotein 0.003830.09671&radic&radic&radic S000001134HXT4YHR092CverifiedHigh-affinity glucose transporter of the major facilitatorsuperfamily, expression is induced by lowlevels of glucose and repressed by high levelsof glucose 0.003820.09671&radic&radic&radic&radic&radic&radic&radic&radic S000003651ASF1YJL115WverifiedNucleosome assembly factor, involved in chromatin assembly anddisassembly, anti-silencing protein that causesderepression of silent loci when overexpressed 0.003830.09671 S000001550YNK1YKL067WverifiedNucleoside diphosphate kinase, catalyzes the transfer of gammaphosphates from nucleoside triphosphates,usually ATP, to nucleoside diphosphates by amechanism that involves formation of anautophosphorylated enzyme intermediate 0.003820.09624&radic&radic&radic&radic&radic&radic S000005361PHO80YOL001WverifiedCyclin, negatively regulates phosphate metabolism;Pho80p-Pho85p (cyclin-CDK complex)phosphorylates Pho4p and Swi5p; deletion ofPHO80 leads to aminoglycoside supersensitivity;truncated form of PHO80 affects vacuoleinheritance 0.003820.09624&radic&radic&radic&radic&radic&radic&radic&radic S000004099AHP1YLR109WverifiedThiol-specific peroxiredoxin, reduces hydroperoxides to protectagainst oxidative damage; function in vivorequires covalent conjugation to Urm1p 0.003820.09624&radic&radic&radic&radic S000000544GID7YCL039WverifiedProtein of unknown function, involved in proteasome-dependentcatabolite inactivation offructose-1,6-bisphosphatase; contains six WD40repeats; computational analysis suggests thatGid7p and Moh1p have similar functions 0.003820.09624&radic&radic&radic&radic&radic&radic&radic&radic S000000510PGS1YCL004WverifiedPhosphatidylglycerolphosphate synthase, catalyzes the synthesisof phosphatidylglycerolphosphate fromCDP-diacylglycerol and sn-glycerol 3-phosphatein the first committed and rate-limiting stepof cardiolipin biosynthesis 0.003820.09624&radic&radic&radic&radic&radic&radic&radic&radic S000003682IDS2YJL146WverifiedProtein involved in modulation of Ime2p activity duringmeiosis, appears to act indirectly to promoteIme2p-mediated late meiotic functions; found ingrowing cells and degraded during sporulation 0.00380.09576&radic&radic&radic&radic&radic&radic&radic&radic S000003267YGR035CUncharacterizedPutative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance 0.00380.09576&radic&radic&radic&radic&radic&radic&radic&radic S000003258YGR026WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery 0.00380.09576&radic&radic&radic&radic&radic&radic&radic&radic S000001688LOS1YKL205WverifiedNuclear pore protein involved in nuclear export of pre-tRNA 0.003790.09542&radic&radic&radic&radic&radic&radic&radic&radic S000001484MET14YKL001CverifiedAdenylylsulfate kinase, required for sulfate assimilation andinvolved in methionine metabolism 0.003790.09542&radic&radic&radic&radic&radic&radic&radic&radic S000001665FAS1YKL182WverifiedBeta subunit of fatty acid synthetase, which catalyzes thesynthesis of long-chain saturated fatty acids;contains acetyltransacylase, dehydratase, enoylreductase, malonyl transacylase, and palmitoyltransacylase activities &radic0.003780.09539&radic&radic&radic&radic&radic&radic&radic&radic S000005387MDM38YOL027CverifiedMitochondrial inner membrane protein, required for K+/H+exchange and for normal mitochondrialmorphology and inheritance; associates withmitochondrial ribosomes; human ortholog Letm1is implicated in Wolf-Hirschhorn syndrome 0.003780.09479&radic&radic&radic&radic&radic&radic S000002796RVS167YDR388WverifiedActin-associated protein, subunit of a complex(Rvs161p-Rvs167p) involved in regulation ofactin cytoskeleton, endocytosis, and viabilityfollowing starvation or osmotic stress; homologof mammalian amphiphysin 0.003780.09479&radic&radic&radic&radic&radic S000001575BUD2YKL092CverifiedGTPase activating factor for Rsr1p/Bud1p required for bothaxial and bipolar budding patterns; mutantsexhibit random budding in all cell types 0.003780.09479&radic&radic&radic&radic&radic&radic&radic&radic S000003689INO1YJL153CverifiedInositol 1-phosphate synthase, involved in synthesis ofinositol phosphates and inositol-containingphospholipids; transcription is coregulatedwith other phospholipid biosynthetic genes byIno2p and Ino4p, which bind the UASINO DNAelement 0.003760.09384&radic&radic&radic&radic&radic&radic S000000476HSM3YBR272CverifiedProtein of unknown function, involved in DNA mismatch repairduring slow growth; has weak similarity toMsh1p 0.003750.09384 S000006161HSP82YPL240CverifiedCytoplasmic chaperone (Hsp90 family) required for pheromonesignaling and negative regulation of Hsf1p;docks with the mitochondrial import receptorTom70p for preprotein delivery; interacts withco-chaperones Cns1p, Cpr6p, Cpr7p, and Sti1p 0.003760.09384&radic&radic&radic&radic&radic S000003704SET2YJL168CverifiedHistone methyltransferase with a role in transcriptionalelongation, methylates a lysine residue ofhistone H3; associates with the C-terminaldomain of Rpo21p; histone methylation activityis regulated by phosphorylation status ofRpo21p 0.003770.09384&radic&radic&radic&radic S000001268YIA6YIL006WverifiedMitochondrial NAD+ transporter, involved in the transport ofNAD+ into the mitochondria (see also YEA6);member of the mitochondrial carrier subfamily;disputed role as a pyruvate transporter; hasputative mouse and human orthologs 0.003740.09384&radic&radic&radic&radic&radic&radic S000004564TAF13YML098WverifiedTFIID subunit (19 kDa), involved in RNA polymerase IItranscription initiation, similar to histone H4with atypical histone fold motif of Spt3-liketranscription factors 0.003750.09384 S000001488BYE1YKL005CverifiedNegative regulator of transcription elongation, contains aTFIIS-like domain and a PHD finger, multicopysuppressor of temperature-sensitive ess1mutations, probably binds RNA polymerase IIlarge subunit 0.003750.09384 S000005274RPD3YNL330CverifiedHistone deacetylase; regulates transcription and silencing 0.003750.09384&radic S000004065RPL10YLR075WverifiedProtein component of the large (60S) ribosomal subunit,responsible for joining the 40S and 60Ssubunits; regulates translation initiation; hassimilarity to rat L10 ribosomal protein and tomembers of the QM gene family 0.003760.09384&radic&radic S000002971CDH1YGL003CverifiedCell-cycle regulated activator of the anaphase-promotingcomplex/cyclosome (APC/C), which directsubiquitination of mitotic cyclins resulting inexit from mitosis; targets the APC/C tospecific substrates including CDC20, ASE1 andCIN8 0.003750.09384&radic&radic&radic&radic S000001049ERG11YHR007CverifiedLanosterol 14-alpha-demethylase, catalyzes the C-14demethylation of lanosterol to form4,4''-dimethylcholesta-8,14,24-triene-3-beta-ol in theergosterol biosynthesis pathway; member of thecytochrome P450 family 0.003760.09384&radic&radic&radic&radic&radic&radic S000005714MSB1YOR188WverifiedProtein involved in positive regulation of both 1,3-beta-glucansynthesis and the Pkc1p-MAPK pathway, potentialCdc28p substrate; multicopy suppressor oftemperature-sensitive mutations in CDC24 andCDC42, and of mutations in BEM4 0.003760.09384&radic&radic&radic&radic S000002104RPL2AYFR031C-AverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl2Bp and has similarity to E.coli L2 and rat L8 ribosomal proteins 0.003740.09349&radic&radic&radic&radic&radic&radic&radic&radic S000002773ESF1YDR365CverifiedNucleolar protein involved in pre-rRNA processing; depletioncauses severely decreased 18S rRNA levels 0.003740.09349&radic&radic S000003961ENT4YLL038CverifiedProtein of unknown function, contains an N-terminal epsin-likedomain 0.003740.09349&radic&radic&radic&radic S000003958GRC3YLL035WverifiedProtein of unknown function, required for cell growth andpossibly involved in rRNA processing; mRNA iscell cycle regulated 0.003740.09349&radic&radic&radic&radic&radic&radic S000000560KAR4YCL055WverifiedTranscription factor required for gene regulation in repsonseto pheromones; also required during meiosis;exists in two forms, a slower-migrating formmore abundant during vegetative growth and afaster-migrating form induced by pheromone 0.003730.09349&radic&radic&radic&radic S000001786YKR078WVerifiedCytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) 0.003730.09314&radic&radic&radic&radic&radic&radic&radic&radic S000005405PSK2YOL045WverifiedOne of two (see also PSK1) PAS domain containing S/T proteinkinases; regulates sugar flux and translationin response to an unknown metabolite byphosphorylating Ugp1p and Gsy2p (sugar flux)and Caf20p, Tif11p and Sro9p (translation) 0.003730.09314&radic&radic&radic&radic&radic&radic&radic S000004853CUS1YMR240CverifiedProtein required for assembly of U2 snRNP into the spliceosome,forms a complex with Hsh49p and Hsh155p 0.003730.09314&radic&radic S000005732NOC2YOR206WverifiedProtein that forms a nucleolar complex with Mak21p that bindsto 90S and 66S pre-ribosomes, as well as anuclear complex with Noc3p that binds to 66Spre-ribosomes; both complexes mediateintranuclear transport of ribosomal precursors 0.003720.09265&radic&radic&radic S000000119MCM2YBL023CverifiedProtein involved in DNA replication; component of the Mcm2-7hexameric complex that binds chromatin as apart of the pre-replicative complex 0.003720.09265&radic&radic&radic S000003030PYC1YGL062WverifiedPyruvate carboxylase isoform, cytoplasmic enzyme that convertspyruvate to oxaloacetate; highly similar toisoform Pyc2p but differentially regulated;mutations in the human homolog are associatedwith lactic acidosis 0.003720.09265&radic&radic&radic&radic&radic S000000564KRR1YCL059CverifiedEssential nucleolar protein required for the synthesis of 18SrRNA and for the assembly of 40S ribosomalsubunit 0.003710.09265&radic&radic&radic&radic&radic&radic S000001103GIC1YHR061CverifiedProtein of unknown function involved in initiation of buddingand cellular polarization, interacts withCdc42p via the Cdc42/Rac-interactive binding(CRIB) domain 0.003720.09265&radic&radic&radic&radic&radic&radic S000000846ERG28YER044CverifiedEndoplasmic reticulum membrane protein, may facilitateprotein-protein interactions between the Erg26pdehydrogenase and the Erg27p 3-ketoreductaseand/or tether these enzymes to the ER, alsointeracts with Erg6p 0.00370.09218&radic&radic&radic&radic&radic S000005226POP3YNL282WverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends 0.00370.09218&radic&radic&radic&radic&radic&radic&radic&radic S000001273TIR3YIL011WverifiedCell wall mannoprotein of the Srp1p/Tip1p family ofserine-alanine-rich proteins; expressed underanaerobic conditions and required for anaerobicgrowth 0.00370.09218&radic&radic&radic&radic&radic&radic&radic S000003472PFK1YGR240CverifiedAlpha subunit of heterooctameric phosphofructokinase involvedin glycolysis, indispensable for anaerobicgrowth, activated by fructose-2,6-bisphosphateand AMP, mutation inhibits glucose induction ofcell cycle-related genes 0.00370.09218&radic&radic&radic&radic S000004927YMR310CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene 0.00370.09176&radic&radic&radic&radic&radic S000004006PML1YLR016CverifiedSubunit of the RES complex, which is required for nuclearretention of unspliced pre-mRNAs; acts in thesame pathway as Pml39p and Mlp1p 0.003670.09105&radic&radic&radic&radic&radic S000002643PRP42YDR235WverifiedU1 snRNP protein involved in splicing, required for U1 snRNPbiogenesis; contains multipletetriatricopeptide repeats 0.003670.09105&radic&radic&radic&radic&radic&radic S000001907YFR011CUncharacterizedPutative protein of unknown function; localizes to the mitochondrion; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR011C is not an essential gene 0.003670.09105&radic&radic&radic&radic&radic&radic&radic&radic S000001567HOT13YKL084WverifiedMitochondrial intermembrane space protein, first component of apathway mediating assembly of small TIM(Translocase of the Inner Membrane) complexeswhich escort hydrophobic inner membraneproteins en route to the TIM22 complex 0.003670.09105&radic&radic&radic&radic&radic&radic&radic&radic S000000186MRP21YBL090WverifiedMitochondrial ribosomal protein of the large subunit; MRP21exhibits genetic interactions with mutations inthe COX2 and COX3 mRNA 5'-untranslated leadersequences 0.003680.09105&radic&radic&radic&radic&radic&radic&radic S000005383IFM1YOL023WverifiedMitochondrial translation initiation factor 2 0.003680.09105&radic&radic&radic&radic&radic S000000889YER087WUncharacterizedHypothetical protein 0.003670.09105&radic&radic&radic&radic&radic S000004228FAR10YLR238WverifiedProtein involved in G1 cell cycle arrest in response topheromone, in a pathway different from theFar1p-dependent pathway; interacts with Far3p,Far7p, Far8p, Far9p, and Far11p; potentialCdc28p substrate 0.003660.09089&radic&radic&radic&radic&radic&radic&radic&radic S000004752YMR144WUncharacterizedPutative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene 0.003660.09089&radic&radic&radic&radic S000003213RTF1YGL244WverifiedSubunit of the RNA polymerase II-associated Paf1 complex;directly or indirectly regulates DNA-bindingproperties of Spt15p and relative activities ofdifferent TATA elements; involved in telomeremaintenance 0.003660.09089&radic&radic&radic&radic&radic S000001906UBP6YFR010WverifiedUbiquitin-specific protease situated in the base subcomplex ofthe 26S proteasome, releases free ubiquitinfrom branched polyubiquitin chains; deletioncauses hypersensitivity to cycloheximide andother toxic compounds 0.003660.09089&radic&radic&radic&radic S000000887YER085CUncharacterizedHypothetical protein 0.003660.09084&radic&radic&radic&radic&radic&radic&radic&radic&radic S000001592HAP4YKL109WverifiedSubunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5pCCAAT-binding complex, a transcriptionalactivator and global regulator of respiratorygene expression; provides the principalactivation function of the complex 0.003630.0896&radic&radic&radic&radic S000005577YOR051CUncharacterizedNuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts 0.003630.0896&radic&radic&radic&radic&radic S000006120YPL199CUncharacterizedHypothetical protein 0.003650.0896&radic&radic&radic&radic&radic S000000761UTR5YEL035CuncharacterizedProtein of unknown function; transcription may be regulated byGcr1p 0.003630.0896&radic&radic&radic&radic S000006312RPN7YPR108WverifiedEssential, non-ATPase regulatory subunit of the 26S proteasome,similar to another S. cerevisiae regulatorysubunit, Rpn5p, as well as to mammalianproteasome subunits 0.003630.0896&radic&radic S000001616YKL133CUncharacterizedHypothetical protein 0.003660.0896&radic&radic&radic&radic S000002644FMN1YDR236CverifiedRiboflavin kinase, phosphorylates riboflavin to form riboflavinmonophosphate (FMN), which is a necessarycofactor for many enzymes; localizes tomicrosomes and to the mitochondrial innermembrane 0.003650.0896&radic&radic&radic&radic&radic&radic&radic S000002255RPN6YDL097CverifiedEssential, non-ATPase regulatory subunit of the 26S proteasomelid required for the assembly and activity ofthe 26S proteasome; the human homolog (S9protein) partially rescues Rpn6p depletion 0.003630.0896 S000004665RNA14YMR061WverifiedCleavage and polyadenylation factor I (CF I) component involvedin cleavage and polyadenylation of mRNA 3'ends; bridges interaction between Rna15p andHrp1p in the CF I complex 0.003650.0896 S000001922YFR026CUncharacterizedHypothetical protein 0.003640.0896&radic&radic&radic&radic&radic&radic&radic S000005232CAF40YNL288WverifiedEvolutionarily conserved subunit of the CCR4-NOT complexinvolved in controlling mRNA initiation,elongation and degradation; binds Cdc39p 0.003630.0896&radic&radic&radic&radic&radic&radic&radic S000001576MBR1YKL093WverifiedProtein involved in mitochondrial functions and stressresponse; overexpression suppresses growthdefects of hap2, hap3, and hap4 mutants 0.003630.0896&radic&radic&radic&radic&radic&radic&radic S000002406MPH2YDL247WverifiedAlpha-glucoside permease, transports maltose, maltotriose,alpha-methylglucoside, and turanose; identicalto Mph3p; encoded in a subtelomeric position ina region likely to have undergone duplication 0.003640.0896 S000003506TAF1YGR274CverifiedTFIID subunit (145 kDa), involved in RNA polymerase IItranscription initiation, has histoneacetyltransferase activity, involved inpromoter binding and G1/S progression &radic0.003620.08948&radic&radic&radic&radic&radic&radic&radic S000000461POP4YBR257WverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends; binds to the RPR1 RNAsubunit in Rnase P 0.003620.08948&radic&radic&radic&radic&radic&radic&radic&radic&radic S000001899YPI1YFR003CverifiedInhibitor of the type I protein phosphatase Glc7p, which isinvolved in regulation of a variety ofmetabolic processes; overproduction causesdecreased cellular content of glycogen 0.003610.08925&radic&radic&radic&radic S000004011IRC25YLR021WuncharacterizedPutative protein of unknown function; mutant accumulatesunusually high amounts of dityrosine in thesoluble fraction though spores appearwild-type; YLR021W is not an essential gene;null mutant displays increased levels ofspontaneous Rad52 foci 0.003610.08925&radic&radic&radic&radic&radic&radic S000004016SED5YLR026Cverifiedcis-Golgi t-SNARE syntaxin required for vesicular transportbetween the ER and the Golgi complex, binds atleast 9 SNARE proteins 0.003620.08925&radic&radic&radic&radic&radic&radic S000000070ADE1YAR015WverifiedN-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR)synthetase, required for 'de novo' purinenucleotide biosynthesis; red pigmentaccumulates in mutant cells deprived of adenine 0.003620.08925&radic&radic&radic&radic&radic S000005562PEP12YOR036WverifiedTarget membrane receptor (t-SNARE) for vesicular intermediatestraveling between the Golgi apparatus and thevacuole; controls entry of biosynthetic,endocytic, and retrograde traffic into theprevacuolar compartment; syntaxin 0.003610.08915&radic&radic&radic&radic&radic&radic S000003746PEX2YJL210WverifiedRING-finger peroxin, peroxisomal membrane protein with aC-terminal zinc-binding RING domain, formsputative translocation subcomplex with Pex10pand Pex12p which functions in peroxisomalmatrix protein import 0.00360.08866&radic&radic&radic&radic&radic S000005283YRF1-6YNL339CverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p 0.003610.08866&radic&radic&radic S000005251MCK1YNL307CverifiedProtein serine/threonine/tyrosine (dual-specificity) kinaseinvolved in control of chromosome segregationand in regulating entry into meiosis; relatedto mammalian glycogen synthase kinases of theGSK-3 family 0.00360.08866&radic&radic&radic&radic&radic&radic S000005642RPO31YOR116CverifiedRNA polymerase III subunit C160, part of core enzyme; similarto bacterial beta-prime subunit 0.00360.08866&radic&radic&radic&radic&radic&radic&radic S000005750RPB8YOR224CverifiedRNA polymerase subunit ABC14.5, common to RNA polymerases I,II, and III 0.003590.08791&radic&radic&radic&radic&radic&radic S000004815ERG2YMR202WverifiedC-8 sterol isomerase, catalyzes the isomerization of thedelta-8 double bond to the delta-7 position atan intermediate step in ergosterol biosynthesis 0.003580.08791&radic&radic&radic&radic&radic S000000412DUR1,2YBR208CverifiedUrea amidolyase, contains both urea carboxylase and allophanatehydrolase activities, degrades urea to CO2 andNH3; expression sensitive to nitrogencatabolite repression and induced byallophanate, an intermediate in allantoindegradation 0.003580.08791&radic&radic&radic&radic&radic S000002578HSP42YDR171WverifiedSmall cytosolic stress-induced chaperone that formsbarrel-shaped oligomers and suppresses theaggregation of non-native proteins; oligomerdissociation is not required for function;involved in cytoskeleton reorganization afterheat shock 0.003580.08791&radic&radic&radic&radic&radic&radic&radic S000003933PSR1YLL010CverifiedPlasma membrane associated protein phosphatase involved in thegeneral stress response; required along withbinding partner Whi2p for full activation ofSTRE-mediated gene expression, possibly throughdephosphorylation of Msn2p 0.003580.08791&radic&radic&radic&radic&radic S000003931DRS1YLL008WverifiedNucleolar DEAD-box protein required for ribosome assembly andfunction, including synthesis of 60S ribosomalsubunits; constituent of 66S pre-ribosomalparticles 0.003590.08791&radic&radic&radic&radic&radic&radic&radic S000004924GAS1YMR307WverifiedBeta-1.3-glucanosyltransferase, required for cell wallassembly; localizes to the cell surface via aglycosylphosphatidylinositol (GPI) anchor 0.00360.08791&radic&radic&radic&radic&radic&radic S000004893CAT8YMR280CverifiedZinc cluster transcriptional activator necessary forderepression of a variety of genes undernon-fermentative growth conditions, activeafter diauxic shift, binds carbon sourceresponsive elements 0.003590.08791&radic&radic&radic&radic&radic&radic&radic&radic S000005435YOL075CUncharacterizedHypothetical protein 0.003580.0878&radic&radic&radic&radic&radic&radic&radic S000003320CTT1YGR088WverifiedCytosolic catalase T, has a role in protection from oxidativedamage by hydrogen peroxide 0.003570.0877&radic&radic&radic&radic&radic&radic&radic S000005697LCB4YOR171CverifiedSphingoid long-chain base kinase, responsible for synthesis oflong-chain base phosphates, which function assignaling molecules, regulates synthesis ofceramide from exogenous long-chain bases,localizes to the Golgi and late endosomes 0.003570.0877&radic&radic&radic&radic&radic&radic&radic S000001238NVJ1YHR195WverifiedNuclear envelope protein that interacts with the vacuolarmembrane protein Vac8p to promote formation ofnucleus-vacuole junctions during piecemealmicroautophagy of the nucleus (PMN) 0.003570.08749&radic&radic&radic&radic&radic&radic&radic&radic S000001209CDC23YHR166CverifiedSubunit of the anaphase-promoting complex/cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition