Yfunc lets you browse current and predicted gene functions in yeast

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Prediction of GO:0016462 "pyrophosphatase activity"

GO branch: MF
Number of currently annotated genes: 264

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest Harbison:IME1_H2O2HiHuh:nucleusLum:CarbendazimLum:5-FCHarbison:HSF1_H2O2LoLum:ImipramineLum:AtenololHuh:cytoplasmLum:MMSLum:Amitriptyline S000002802RPT3YDR394WverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; substrate ofN-acetyltransferase B &radic0.80070.99352&radic&radic&radic&radic&radic S000005042RAS2YNL098CverifiedGTP-binding protein that regulates the nitrogen starvationresponse, sporulation, and filamentous growth;farnesylation and palmitoylation required foractivity and localization to plasma membrane;homolog of mammalian Ras proto-oncogenes &radic0.790060.99352&radic&radic S000001628RPT1YKL145WverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; required for optimalCDC20 transcription; interacts with Rpn12p andthe E3 ubiquitin-protein ligase Ubr1p &radic0.783580.99175&radic&radic S000001889SEC4YFL005WverifiedSecretory vesicle-associated Rab GTPase essential forexocytosis; associates with the exocystcomponent Sec15p and may regulate polarizeddelivery of transport vesicles to the exocystat the plasma membrane &radic0.771560.99175 S000004252YPT6YLR262CverifiedGTPase, Ras-like GTP binding protein involved in the secretorypathway, required for fusion ofendosome-derived vesicles with the late Golgi,maturation of the vacuolar carboxypeptidase Y;has similarity to the human GTPase, Rab6 &radic0.778910.99175&radic&radic S000003016RPT6YGL048CverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; bound byubiquitin-protein ligases Ubr1p and Ufd4p;localized mainly to the nucleus throughout thecell cycle &radic0.772790.99175&radic&radic&radic&radic S000005679PDR5YOR153WverifiedShort-lived membrane ABC (ATP-binding cassette) transporter,actively exports various drugs, expressionregulated by Pdr1p; also involved in steroidtransport, cation resistance, and cellulardetoxification during exponential growth &radic0.755760.98798&radic&radic&radic S000003384RSR1YGR152CverifiedGTP-binding protein of the ras superfamily required for budsite selection, morphological changes inresponse to mating pheromone, and efficientcell fusion; localized to the plasma membrane;significantly similar to mammalian Rap GTPases &radic0.764490.98798&radic&radic&radic&radic&radic&radic&radic S000005627RAS1YOR101WverifiedGTPase involved in G-protein signaling in the adenylate cyclaseactivating pathway, plays a role in cellproliferation; localized to the plasmamembrane; homolog of mammalian RASproto-oncogenes &radic0.756250.98798&radic&radic&radic&radic&radic&radic&radic S000004219CDC42YLR229CverifiedSmall rho-like GTPase, essential for establishment andmaintenance of cell polarity; mutants havedefects in the organization of actin andseptins &radic0.759640.98798 S000001380RHO3YIL118WverifiedNon-essential small GTPase of the Rho/Rac subfamily of Ras-likeproteins involved in the establishment of cellpolarity; GTPase activity positively regulatedby the GTPase activating protein (GAP) Rgd1p &radic0.743310.98645&radic S000003178YPT32YGL210WverifiedGTPase of the Ypt/Rab family, very similar to Ypt31p; involvedin the exocytic pathway; mediates intra-Golgitraffic or the budding of post-Golgi vesiclesfrom the trans-Golgi &radic0.746370.98645&radic&radic S000005643RPT5YOR117WverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; recruited to theGAL1-10 promoter region upon induction oftranscription &radic0.745150.98645&radic&radic&radic&radic S000005785RPT4YOR259CverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; required for spindlepole body duplication; localized mainly to thenucleus throughout the cell cycle &radic0.730830.9851&radic&radic&radic S000000833YPT31YER031CverifiedGTPase of the Ypt/Rab family, very similar to Ypt32p; involvedin the exocytic pathway; mediates intra-Golgitraffic or the budding of post-Golgi vesiclesfrom the trans-Golgi &radic0.726520.98347&radic&radic S000000838ARB1YER036CverifiedATPase of the ATP-binding cassette (ABC) family involved in 40Sand 60S ribosome biogenesis, has similarity toGcn20p; shuttles from nucleus to cytoplasm,physically interacts with Tif6p, Lsg1p &radic0.727190.98347&radic&radic&radic&radic&radic&radic&radic S000001856YPT1YFL038CverifiedRas-like small GTPase, involved in the ER-to-Golgi step of thesecretory pathway; complex formation with theRab escort protein Mrs6p is required forprenylation of Ypt1p by proteingeranylgeranyltransferase type II (Bet2p-Bet4p) &radic0.720950.97692&radic&radic S000004239YEF3YLR249WverifiedTranslational elongation factor, stimulates the binding ofaminoacyl-tRNA (AA-tRNA) to ribosomes byreleasing EF-1 alpha from the ribosomalcomplex; contains two ABC cassettes; binds andhydrolyses ATP 0.72320.97692&radic&radic S000003938BPT1YLL015WverifiedABC type transmembrane transporter of MRP/CFTR family, found invacuolar membrane, involved in the transport ofunconjugated bilirubin and in heavy metaldetoxification via glutathione conjugates,along with Ycf1p 0.712420.97137&radic&radic&radic&radic&radic&radic S000005037YPT53YNL093WverifiedGTPase, similar to Ypt51p and Ypt52p and to mammalian rab5;required for vacuolar protein sorting andendocytosis &radic0.702680.97117 S000002165RPT2YDL007WverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; required for normalpeptide hydrolysis by the core 20S particle &radic0.707950.97117 S000002418SNQ2YDR011WverifiedABC transporter protein involved in multidrug resistance andresistance to singlet oxygen species &radic0.710260.97117&radic S000005234RFC3YNL290WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon &radic0.697560.96985&radic&radic&radic S000000819AFG3YER017CverifiedComponent, with Yta12p, of the mitochondrial inner membranem-AAA protease that mediates degradation ofmisfolded or unassembled proteins and is alsorequired for correct assembly of mitochondrialenzyme complexes &radic0.69540.96842&radic&radic&radic&radic S000003135PMR1YGL167CverifiedHigh affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ andMn2+ transport into Golgi; involved in Ca2+dependent protein sorting and processing;mutations in human homolog ATP2C1 causeacantholytic skin condition Hailey-Haileydisease &radic0.683140.96683 S000005711GSP2YOR185CverifiedGTP binding protein (mammalian Ranp homolog) involved in themaintenance of nuclear organization, RNAprocessing and transport; interacts withKap121p, Kap123p and Pdr6p (karyophilin betas);Gsp1p homolog that is not required forviability &radic0.691050.96683&radic&radic&radic&radic&radic S000001722YPT52YKR014CverifiedGTPase, similar to Ypt51p and Ypt53p and to mammalian rab5;required for vacuolar protein sorting andendocytosis &radic0.674450.96681&radic&radic&radic&radic&radic S000000119MCM2YBL023CverifiedProtein involved in DNA replication; component of the Mcm2-7hexameric complex that binds chromatin as apart of the pre-replicative complex &radic0.676660.96681&radic&radic&radic&radic&radic S000005034RHO2YNL090WverifiedNon-essential small GTPase of the Rho/Rac subfamily of Ras-likeproteins, involved in the establishment of cellpolarity and in microtubule assembly &radic0.6790.96681&radic&radic S000004460YPT7YML001WverifiedGTPase; GTP-binding protein of the rab family; required forhomotypic fusion event in vacuole inheritance,for endosome-endosome fusion, similar tomammalian Rab7 &radic0.669420.96681&radic&radic&radic&radic&radic&radic S000002351ARF1YDL192WverifiedADP-ribosylation factor, GTPase of the Ras superfamily involvedin regulation of coated formation vesicles inintracellular trafficking within the Golgi;functionally interchangeable with Arf2p &radic0.6750.96681&radic&radic&radic&radic S000001680PEX1YKL197CverifiedAAA-family ATPase peroxin required for peroxisome biogenesis,contains two 230 amino acid ATP-binding AAAcassettes, upregulated in anaerobiosis; Pex1pand Pex6p interact via their N-terminalAAA-cassettes &radic0.676150.96681&radic&radic S000005615VPS21YOR089CverifiedGTPase required for transport during endocytosis and forcorrect sorting of vacuolar hydrolases;localized in endocytic intermediates; detectedin mitochondria; geranylgeranylation requiredfor membrane association; mammalian Rab5homolog &radic0.669730.96681&radic&radic&radic&radic&radic&radic S000001763RHO4YKR055WverifiedNon-essential small GTPase of the Rho/Rac subfamily of Ras-likeproteins, likely to be involved in theestablishment of cell polarity &radic0.673330.96681&radic&radic&radic&radic&radic&radic&radic S000000758MCM3YEL032WverifiedProtein involved in DNA replication; component of the Mcm2-7hexameric complex that binds chromatin as apart of the pre-replicative complex &radic0.662880.96681&radic&radic&radic S000005162MGS1YNL218WverifiedProtein with DNA-dependent ATPase and ssDNA annealingactivities involved in maintenance of genome;interacts functionally with DNA polymerasedelta; homolog of human Werner helicaseinteracting protein (WHIP) &radic0.660070.96681&radic&radic&radic&radic&radic&radic&radic&radic&radic S000006228YME1YPR024WverifiedSubunit, with Mgr1p, of the mitochondrial inner membrane i-AAAprotease complex, which is responsible fordegradation of unfolded or misfoldedmitochondrial gene products; mutation causes anelevated rate of mitochondrial turnover 0.65850.96339 S000003829RFC2YJR068WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon &radic0.657920.96339&radic S000000406CDC47YBR202WverifiedComponent of the hexameric MCM complex, which is important forpriming origins of DNA replication in G1 andbecomes an active ATP-dependent helicase thatpromotes DNA melting and elongation whenactivated by Cdc7p-Dbf4p in S-phase &radic0.650550.96226&radic&radic&radic&radic&radic&radic&radic S000003971YBT1YLL048CverifiedTransporter of the ATP-binding cassette (ABC) family involvedin bile acid transport; similar to mammalianbile transporters &radic0.637940.95805 S000006027SSE1YPL106CverifiedATPase that is a component of the heat shock protein Hsp90chaperone complex; binds unfolded proteins;member of the heat shock protein 70 (HSP70)family; localized to the cytoplasm 0.646710.95805&radic&radic&radic&radic&radic&radic S000002296ARF2YDL137WverifiedADP-ribosylation factor, GTPase of the Ras superfamily involvedin regulation of coated formation vesicles inintracellular trafficking within the Golgi;functionally interchangeable with Arf1p &radic0.64430.95805&radic S000004284GSP1YLR293CverifiedGTP binding protein (mammalian Ranp homolog) involved in themaintenance of nuclear organization, RNAprocessing and transport; regulated by Prp20p,Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p andKap95p; yeast Gsp2p homolog &radic0.630750.958&radic&radic&radic&radic&radic&radic S000003513YOR1YGR281WverifiedPlasma membrane transporter of the ATP-binding cassette (ABC)family, mediates export of many differentorganic anions including oligomycin &radic0.629260.958&radic&radic&radic S000004959HEF3YNL014WverifiedTranslational elongation factor EF-3; paralog of YEF3 andmember of the ABC superfamily; stimulates EF-1alpha-dependent binding of aminoacyl-tRNA bythe ribosome; normally expressed in zincdeficient cells &radic0.629630.958 S000002447ENA1YDR040CverifiedP-type ATPase sodium pump, involved in Na+ and Li+ efflux toallow salt tolerance &radic0.59150.95765&radic S000006223CDC54YPR019WverifiedEssential helicase component of heterohexameric MCM2-7complexes which bind pre-replication complexeson DNA and melt the DNA prior to replication;accumulates in the nucleus in G1; homolog of S.pombe Cdc21p &radic0.577830.95765&radic&radic S000006369RHO1YPR165WverifiedGTP-binding protein of the rho subfamily of Ras-like proteins,involved in establishment of cell polarity;regulates protein kinase C (Pkc1p) and the cellwall synthesizing enzyme 1,3-beta-glucansynthase (Fks1p and Gsc2p) &radic0.598660.95765&radic&radic&radic S000000368ARL1YBR164CverifiedSoluble GTPase with a role in regulation of membrane traffic;regulates potassium influx; G protein of theRas superfamily, similar to ADP-ribosylationfactor &radic0.580980.95765&radic S000006068PXA1YPL147WverifiedSubunit of a heterodimeric peroxisomal ATP-binding cassettetransporter complex (Pxa1p-Pxa2p), required forimport of long-chain fatty acids intoperoxisomes; similarity to humanadrenoleukodystrophy transporter andALD-related proteins &radic0.596280.95765&radic&radic&radic S000005957PMA2YPL036WverifiedPlasma membrane H+-ATPase, isoform of Pma1p, involved inpumping protons out of the cell; regulator ofcytoplasmic pH and plasma membrane potential &radic0.558960.95765 S000004695YTA12YMR089CverifiedComponent, with Afg3p, of the mitochondrial inner membranem-AAA protease that mediates degradation ofmisfolded or unassembled proteins and is alsorequired for correct assembly of mitochondrialenzyme complexes &radic0.614550.95765 S000003169MCM6YGL201CverifiedProtein involved in DNA replication; component of the Mcm2-7hexameric complex that binds chromatin as apart of the pre-replicative complex &radic0.553650.95765&radic&radic&radic&radic&radic S000006147NEW1YPL226WverifiedATP binding cassette family member; Asn/Gln-rich rich regionsupports [NU+] prion formation, susceptibilityto [PSI+] prion induction and aggregation of afragment of the human Machado-Joseph Diseaseprotein &radic0.567630.95765&radic&radic&radic S000003610SMC3YJL074CverifiedSubunit of the multiprotein cohesin complex required for sisterchromatid cohesion in mitotic cells; alsorequired, with Rec8p, for cohesion andrecombination during meiosis; phylogeneticallyconserved SMC chromosomal ATPase family member &radic0.59930.95765&radic&radic S000002976PMA1YGL008CverifiedPlasma membrane H+-ATPase, pumps protons out of the cell; majorregulator of cytoplasmic pH and plasma membranepotential; part of the P2 subgroup ofcation-transporting ATPases &radic0.614490.95765&radic&radic&radic&radic S000004683CTF18YMR078CverifiedSubunit of a complex with Ctf8p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion; may have overlappingfunctions with Rad24p in the DNA damagereplication checkpoint 0.622310.95765&radic&radic S000005995YTA6YPL074WverifiedPutative ATPase of the CDC48/PAS1/SEC18 (AAA) family, localizedto the cortex of mother cells but not todaughter cells &radic0.610150.95765&radic&radic&radic&radic&radic&radic S000000318RAD16YBR114WverifiedProtein that recognizes and binds damaged DNA in anATP-dependent manner (with Rad7p) duringnucleotide excision repair; subunit ofNucleotide Excision Repair Factor 4 (NEF4);member of the SWI/SNF family &radic0.615630.95765&radic&radic S000005273PEX6YNL329CverifiedPeroxisomal membrane AAA-family ATPase peroxin required forperoxisome assembly, contains two 230 aminoacid ATP-binding AAA cassettes, interacts withPex1p &radic0.583220.95765&radic&radic S000005859VMA4YOR332WverifiedSubunit E of the eight-subunit V1 peripheral membrane domain ofthe vacuolar H+-ATPase (V-ATPase), anelectrogenic proton pump found throughout theendomembrane system; required for the V1 domainto assemble onto the vacuolar membrane &radic0.565010.95765&radic&radic&radic S000004022RAD5YLR032WverifiedSingle-stranded DNA-dependent ATPase, involved inpostreplication repair; contains RING fingerdomain &radic0.559840.95765&radic&radic&radic S000003118INO80YGL150CverifiedATPase that forms a large complex, containing actin and severalactin-related proteins, that has chromatinremodeling activity and 3' to 5' DNA helicaseactivity in vitro; shows similarity to theSnf2p family of ATPases &radic0.575610.95765&radic S000005454RFC4YOL094CverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon &radic0.618840.95765&radic&radic S000001671PXA2YKL188CverifiedSubunit of a heterodimeric peroxisomal ATP-binding cassettetransporter complex (Pxa1p-Pxa2p), required forimport of long-chain fatty acids intoperoxisomes; similarity to humanadrenoleukodystrophy transporter andALD-related proteins &radic0.571280.95765&radic&radic&radic&radic S000006377VPS4YPR173CverifiedAAA-type ATPase required for efficient late endosome to vacuoletransport; catalyzes the release of anendosomal membrane-associated class E VPSprotein complex; regulates cellular sterolmetabolism; cytoplasmic and endosomallocalization &radic0.604950.95765&radic&radic&radic&radic S000000331VMA2YBR127CverifiedSubunit B of the eight-subunit V1 peripheral membrane domain ofthe vacuolar H+-ATPase (V-ATPase), anelectrogenic proton pump found throughout theendomembrane system; contains nucleotidebinding sites; also detected in the cytoplasm &radic0.61460.95765 S000005743RFC1YOR217WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon &radic0.593030.95765&radic&radic&radic&radic S000006240VMA13YPR036WverifiedSubunit H of the eight-subunit V1 peripheral membrane domain ofthe vacuolar H+-ATPase (V-ATPase), anelectrogenic proton pump found throughout theendomembrane system; serves as an activator ora structural stabilizer of the V-ATPase &radic0.568760.95765 S000001905GCN20YFR009WverifiedPositive regulator of the Gcn2p kinase activity, forms acomplex with Gcn1p; proposed to stimulate Gcn2pactivation by an uncharged tRNA &radic0.612420.95765&radic&radic&radic S000005537AUS1YOR011WverifiedTransporter of the ATP-binding cassette family, involved inuptake of sterols and anaerobic growth &radic0.564190.95765&radic&radic&radic&radic S000004264CDC46YLR274WverifiedComponent of the hexameric MCM complex, which is important forpriming origins of DNA replication in G1 andbecomes an active ATP-dependent helicase thatpromotes DNA melting and elongation whenactivated by Cdc7p-Dbf4p in S-phase &radic0.606190.95765&radic&radic&radic S000001275PDR11YIL013CverifiedMembrane protein of the ATP-binding cassette (ABC) transportersuperfamily, involved in multiple drugresistance, mediates sterol uptake when sterolbiosynthesis is compromised, regulated byPdr1p, required for anaerobic growth &radic0.616970.95765&radic&radic&radic S000005972ARL3YPL051WverifiedGTPase of the Ras superfamily required to recruit Arl1p to theGolgi; similar to ADP-ribosylation factor &radic0.55170.95758&radic&radic&radic&radic&radic S000003131RAD54YGL163CverifiedDNA-dependent ATPase, stimulates strand exchange by modifyingthe topology of double-stranded DNA; involvedin the recombinational repair of double-strandbreaks in DNA during vegetative growth andmeiosis; member of the SWI/SNF family &radic0.545830.95758&radic&radic S000004178MDL1YLR188WverifiedHalf-type ATP-binding cassette (ABC) transporter of the innermitochondrial membrane, mediates export ofpeptides generated upon proteolysis ofmitochondrial proteins, plays a role in theregulation of cellular resistance to oxidativestress &radic0.545890.95758&radic&radic&radic&radic&radic S000002284CDC48YDL126CverifiedATPase in ER, nuclear membrane and cytosol with homology tomammalian p97; in a complex with Npl4p andUfd1p participates in retrotranslocation ofubiquitinated proteins from the ER into thecytosol for degradation by the proteasome &radic0.548330.95758&radic&radic&radic S000001310NEO1YIL048WverifiedProtein involved in the retrograde transport from the Golgicomplex to the ER and the endosomal membranetraffic; putative aminophospholipidtranslocase; member of the highly conservedDrs2 family of P-type ATPases &radic0.548720.95758&radic&radic&radic&radic S000002542YCF1YDR135CverifiedVacuolar glutathione S-conjugate transporter of the ATP-bindingcassette family, has a role in detoxifyingmetals such as cadmium, mercury, and arsenite;also transports unconjugated bilirubin; similarto human cystic fibrosis protein CFTR &radic0.549930.95758&radic&radic&radic&radic&radic S000004916ATM1YMR301CverifiedMitochondrial inner membrane transporter, exportsmitochondrially synthesized precursors ofiron-sulfur (Fe/S) clusters to the cytosol;member of the ATP-binding cassette (ABC)transporter family &radic0.54930.95758&radic&radic&radic&radic&radic&radic S000002100VMA10YHR039C-AverifiedVacuolar H+ ATPase subunit G of the catalytic (V1) sector,involved in vacuolar acidification &radic0.549280.95758 S000000622RHB1YCR027CverifiedPutative Rheb-related GTPase involved in regulating canavanineresistance and arginine uptake; member of theRas superfamily of G-proteins &radic0.534480.95695&radic S000005855PDR10YOR328WverifiedABC (ATP-binding cassette) membrane pump involved in thepleiotropic drug resistance network, regulatedby Pdr1p and Pdr3p, similar to Pdr5p &radic0.53120.95567&radic&radic&radic&radic S000004439VMA6YLR447CverifiedSubunit D of the five-subunit V0 integral membrane domain ofvacuolar H+-ATPase (V-ATPase), an electrogenicproton pump found in the endomembrane system;stabilizes VO subunits; required for V1 domainassembly on the vacuolar membrane &radic0.530460.95494 S000005056DBP2YNL112WverifiedEssential ATP-dependent RNA helicase of the DEAD-box proteinfamily, involved in nonsense-mediated mRNAdecay and rRNA processing 0.530430.95396&radic&radic S000001894SPB4YFL002CverifiedPutative ATP-dependent RNA helicase, nucleolar protein requiredfor synthesis of 60S ribosomal subunits at alate step in the pathway; sediments with 66Spre-ribosomes in sucrose gradients &radic0.524410.95396&radic&radic S000003796RAD26YJR035WverifiedProtein involved in transcription-coupled repair nucleotideexcision repair of UV-induced DNA lesions;homolog of human CSB protein &radic0.530220.95396&radic&radic&radic S000003957RIX7YLL034CverifiedPutative ATPase of the AAA family, required for export ofpre-ribosomal large subunits from the nucleus;distributed between the nucleolus, nucleoplasm,and nuclear periphery depending on growthconditions &radic0.525740.95396&radic&radic&radic&radic&radic&radic&radic S000004529TEM1YML064CverifiedGTP-binding protein of the ras superfamily involved intermination of M-phase; controls actomyosin andseptin dynamics during cytokinesis &radic0.526190.95396 S000000284SEC18YBR080CverifiedATPase required for the release of Sec17p during the 'priming'step in homotypic vacuole fusion and for ER toGolgi transport; homolog of the mammalian NSF &radic0.518080.95389&radic S000002974PMC1YGL006WverifiedVacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ions; prevents growth inhibition by activationof calcineurin in the presence of elevatedconcentrations of calcium; similar to mammalianPMCA1a &radic0.518670.95389&radic&radic S000005353YNR070WUncharacterizedPutative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance &radic0.519120.95389&radic S000001563VMA5YKL080WverifiedSubunit C of the eight-subunit V1 peripheral membrane domain ofvacuolar H+-ATPase (V-ATPase), an electrogenicproton pump found throughout the endomembranesystem; required for the V1 domain to assembleonto the vacuolar membrane &radic0.514640.95304&radic&radic S000000688MSH3YCR092CverifiedMismatch repair protein, forms dimers with Msh2p that mediaterepair of insertion or deletion mutations andremoval of nonhomologous DNA ends, contains aPCNA (Pol30p) binding motif required for genomestability 0.510750.95068&radic&radic&radic&radic&radic&radic S000005979PDR12YPL058CverifiedPlasma membrane weak-acid-inducible ATP-binding cassette (ABC)transporter, required for weak organic acidresistance, strongly induced by sorbate andbenzoate, regulated by War1p, mutants exhibitsorbate hypersensitivity &radic0.509810.95068&radic&radic&radic S000004076SMC4YLR086WverifiedSubunit of the condensin complex, which reorganizes chromosomesduring cell division, forms a stable complexwith Smc2p that has ATP-hydrolyzing andDNA-binding activity and promotes knotting ofcircular DNA; potential Cdc28p substrate &radic0.510820.95068&radic&radic&radic&radic S000006139SAR1YPL218WverifiedGTPase, GTP-binding protein of the ARF family, component ofCOPII coat of vesicles; required for transportvesicle formation during ER to Golgi proteintransport &radic0.504060.95058&radic&radic S000002498RLI1YDR091CverifiedEssential iron-sulfur protein required for ribosome biogenesisand translation initiation; facilitates bindingof a multifactor complex (MFC) of translationinitiation factors to the small ribosomalsubunit; predicted ABC family ATPase &radic0.50760.95058&radic&radic&radic S000000966CHD1YER164WverifiedNucleosome remodeling factor that functions in regulation oftranscription elongation; contains a chromodomain, a helicase domain and a DNA-bindingdomain; component of both the SAGA and SILKcomplexes &radic0.506210.95058&radic S000002598RVB1YDR190CverifiedEssential protein involved in transcription regulation;component of chromatin remodeling complexes;required for assembly and function of the INO80complex; member of the RUVB-like protein family &radic0.505030.95058&radic&radic&radic&radic&radic S000000277RDH54YBR073WverifiedDNA-dependent ATPase, stimulates strand exchange by modifyingthe topology of double-stranded DNA; involvedin the recombinational repair of double-strandbreaks in DNA during mitosis and meiosis;proposed to be involved in crossoverinterference &radic0.508080.95058&radic&radic S000001388STH1YIL126WverifiedATPase component of the ATP-dependent RSC chromatin remodelingcomplex required for kinetochore function inchromosome segregation; required for expressionof early meiotic genes; essentialhelicase-related protein homologous to Snf2p &radic0.503990.95058&radic S000003949HSP104YLL026WverifiedHeat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p(Hsp70) to refold and reactivate previouslydenatured, aggregated proteins; responsive tostresses including: heat, ethanol, and sodiumarsenite; involved in [PSI+] propagation &radic0.495040.94805&radic&radic&radic&radic&radic S000005435YOL075CUncharacterizedHypothetical protein &radic0.496450.94805&radic&radic&radic&radic S000000468YPT10YBR264CverifiedGTP binding protein that contains the PEST signal sequencespecific for proteolytic enzymes; may beinvolved in vesicular transport; overexpressionleads to accumulation of Golgi-like cisternaewith budding vesicles &radic0.492830.94787&radic&radic&radic S000000757SPF1YEL031WverifiedP-type ATPase, ion transporter of the ER membrane involved inER function and Ca2+ homeostasis; required forregulating Hmg2p degradation; conferssensitivity to a killer toxin (SMKT) producedby Pichia farinosa KK1 &radic0.493210.94787&radic&radic&radic&radic S000002468YDR061WUncharacterizedMitochondrial protein, member of the ATP-binding cassette (ABC) transporter family; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance &radic0.492810.94787&radic&radic&radic&radic&radic&radic&radic S000002814PDR15YDR406WverifiedATP binding cassette (ABC) transporter of the plasma membrane;general stress response factor implicated incellular detoxification; target of Pdr1p, Pdr3pand Pdr8p transcription regulators; promotercontains a PDR responsive element &radic0.492870.94787&radic&radic&radic&radic&radic S000001886SMC1YFL008WverifiedSubunit of the multiprotein cohesin complex, essential proteininvolved in chromosome segregation and indouble-strand DNA break repair; SMC chromosomalATPase family member, binds DNA with apreference for DNA with secondary structure &radic0.485410.9476&radic&radic&radic&radic&radic&radic S000003252VMA7YGR020CverifiedSubunit F of the eight-subunit V1 peripheral membrane domain ofvacuolar H+-ATPase (V-ATPase), an electrogenicproton pump found throughout the endomembranesystem; required for the V1 domain to assembleonto the vacuolar membrane &radic0.479880.9465&radic&radic&radic S000001866CAF16YFL028CverifiedPart of the evolutionarily-conserved CCR4-NOT transcriptionalregulatory complex involved in controlling mRNAinitiation, elongation, and degradation;putative ABC ATPase; interacts with Ssn2p,Ssn3p, and Ssn8p &radic0.480110.9465&radic&radic&radic&radic S000005817YOR291WUncharacterizedHypothetical protein 0.484560.9465&radic&radic&radic S000001027VMR1YHL035CverifiedProtein of unknown function that may interact with ribosomes,based on co-purification experiments; member ofthe ATP-binding cassette (ABC) family;potential Cdc28p substrate; detected inpurified mitochondria in high-throughputstudies &radic0.478840.9465&radic&radic S000000024DRS2YAL026CverifiedAminophospholipid translocase (flippase) that maintainsmembrane lipid asymmetry in post-Golgisecretory vessicles; localizes to thetrans-Golgi network; contributes toclathrin-coated vesicle formation andendocytosis; type 4 P-type ATPase &radic0.476390.94558&radic&radic&radic S000005124RHO5YNL180CverifiedNon-essential small GTPase of the Rho/Rac subfamily of Ras-likeproteins, likely involved in protein kinase C(Pkc1p)-dependent signal transduction pathwaythat controls cell integrity &radic0.475470.94558&radic&radic&radic&radic&radic S000001212DBP8YHR169WverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in biogenesis of the 40S ribosomalsubunit &radic0.474670.94378&radic S000005730DED1YOR204WverifiedATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, requiredfor translation initiation of all yeast mRNAs;mutations in human DEAD-box DBY are a frequentcause of male infertility 0.475130.94378&radic&radic&radic&radic&radic S000002783BCS1YDR375CverifiedProtein of the mitochondrial inner membrane that functions asan ATP-dependent chaperone, required for theassembly of the cytochrome bc(1) complex fromthe Rip1p and Qcr10p proteins; member of theCDC48/PAS1/SEC18 ATPase family &radic0.471860.94224&radic&radic&radic&radic&radic S000000604ADP1YCR011CverifiedPutative ATP-dependent permease of the ABC transporter familyof proteins &radic0.469290.94032&radic&radic S000002446ENA2YDR039CverifiedP-type ATPase sodium pump, involved in Na+ efflux to allow salttolerance; likely not involved in Li+ efflux &radic0.467920.93856 S000000118PIM1YBL022CverifiedMitochondrial ATP-dependent protease involved inintramitochondrial proteolysis; involved indegradation of misfolded proteins inmitochondria; required for bigenesis andmaintenance of mitochondria 0.468210.93856&radic&radic&radic S000006191MDL2YPL270WverifiedHalf-type ATP-binding cassette (ABC) transporter of the innermitochondrial membrane &radic0.463370.93854&radic&radic&radic&radic&radic S000000849SAP1YER047CverifiedPutative ATPase of the AAA family, interacts with the Sin1ptranscriptional repressor in the two-hybridsystem &radic0.4620.93854&radic&radic&radic&radic&radic&radic&radic S000004389AFG2YLR397CverifiedATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexamericcomplex; may be involved in degradation ofaberrant mRNAs &radic0.463750.93854&radic&radic&radic&radic&radic&radic&radic S000004530ORC1YML065WverifiedLargest subunit of the origin recognition complex, whichdirects DNA replication by binding toreplication origins and is also involved intranscriptional silencing; may bephosphorylated by Cdc28p &radic0.456350.93754 S000001692STE6YKL209CverifiedATP-binding cassette (ABC) transporter required for the exportof a-factor, catalyzes ATP hydrolysis coupledto a-factor transport, contains 12transmembrane domains and two ATP bindingdomains, expressed only in MATa cells &radic0.458570.93754&radic&radic&radic&radic S000000981DMC1YER179WverifiedMeiosis-specific protein required for repair of double-strandbreaks and pairing between homologouschromosomes; homolog of Rad51p and thebacterial RecA protein 0.461310.93754&radic S000002445ENA5YDR038CverifiedProtein with similarity to P-type ATPase sodium pumps &radic0.445090.93584 S000004746CIN4YMR138WverifiedGTP-binding protein involved in beta-tubulin (Tub2p) folding;isolated as mutant with increased chromosomeloss and sensitivity to benomyl 0.452860.93584&radic S000001811NFT1YKR103WverifiedPutative transporter of the multidrug resistance-associatedprotein (MRP) subfamily; adjacent ORFs YKR103Wand YKR104W are merged in different strainbackgrounds. &radic0.443660.93584&radic&radic&radic S000003502YTA7YGR270WverifiedProtein of unknown function, member of CDC48/PAS1/SEC18 familyof ATPases, potentially phosphorylated byCdc28p &radic0.44510.93584&radic&radic&radic S000003947SSA2YLL024CverifiedATP binding protein involved in protein folding and vacuolarimport of proteins; member of heat shockprotein 70 (HSP70) family; associated with thechaperonin-containing T-complex; present in thecytoplasm, vacuolar membrane and cell wall &radic0.441110.9357&radic&radic&radic&radic&radic S000005062DCP2YNL118CverifiedCatalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex,which removes the 5' cap structure from mRNAsprior to their degradation; member of the Nudixhydrolase family &radic0.433680.9357 S000000449ISW1YBR245CverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPase thatforms a complex with Ioc2p and Ioc4p toregulate transcription elongation, and acomplex with Ioc3p to repress transcriptioninitiation &radic0.429870.93449&radic&radic&radic&radic&radic S000001441MPH1YIR002CverifiedMember of the DEAH family of helicases, functions in anerror-free DNA damage bypass pathway thatinvolves homologous recombination, mutationsconfer a mutator phenotype 0.428990.93241&radic&radic S000000004SSA1YAL005CverifiedATPase involved in protein folding and nuclear localizationsignal (NLS)-directed nuclear transport; memberof heat shock protein 70 (HSP70) family; formsa chaperone complex with Ydj1p; localized tothe nucleus, cytoplasm, and cell wall &radic0.42710.93226&radic&radic&radic&radic&radic S000000346MAK5YBR142WverifiedEssential nucleolar protein, putative DEAD-box RNA helicaserequired for maintenance of M1 dsRNA virus;involved in biogenesis of large (60S) ribosomalsubunits &radic0.422980.93125&radic S000000777VMA8YEL051WverifiedSubunit D of the eight-subunit V1 peripheral membrane domain ofthe vacuolar H+-ATPase (V-ATPase), anelectrogenic proton pump found throughout theendomembrane system; plays a role in thecoupling of proton transport and ATP hydrolysis &radic0.422830.93125&radic&radic&radic&radic&radic&radic S000000017FUN30YAL019WverifiedProtein whose overexpression affects chromosome stability,potential Cdc28p substrate; homolog of Snf2p;the authentic, non-tagged protein is detectedin highly purified mitochondria inhigh-throughput studies 0.421260.92878&radic&radic&radic&radic S000005796VPH1YOR270CverifiedSubunit of vacuolar-ATPase V0 domain, one of two isoforms(Vph1p and Stv1p); Vph1p is located in V-ATPasecomplexes of the vacuole while Stv1p is locatedin V-ATPase complexes of the Golgi andendosomes &radic0.415830.92767 S000003570HCA4YJL033WverifiedPutative nucleolar DEAD box RNA helicase; high-copy numbersuppression of a U14 snoRNA processing mutantsuggests an involvement in 18S rRNA synthesis &radic0.413270.92767 S000005831ISW2YOR304WverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPasecomponent that, with Itc1p, forms a complexrequired for repression of a-specific genes,INO1, and early meiotic genes during mitoticgrowth &radic0.411510.92719&radic&radic&radic&radic&radic&radic&radic S000003260MSP1YGR028WverifiedMitochondrial protein involved in sorting of proteins in themitochondria; putative membrane-spanning ATPase &radic0.400470.92138 S000003794RAV1YJR033CverifiedSubunit of the RAVE complex (Rav1p, Rav2p, Skp1p), whichpromotes assembly of the V-ATPase holoenzyme;required for transport between the early andlate endosome/PVC and for localization of TGNmembrane proteins; potential Cdc28p substrate 0.397740.91925&radic S000000968DNF1YER166WverifiedAminophospholipid translocase (flippase) that localizesprimarily to the plasma membrane; contributesto endocytosis, protein transport and cellpolarity; type 4 P-type ATPase &radic0.396880.91925&radic S000002388SSB1YDL229WverifiedCytoplasmic ATPase that is a ribosome-associated molecularchaperone, functions with J-protein partnerZuo1p; may be involved in folding of newly-madepolypeptide chains; member of the HSP70 family;interacts with phosphatase subunit Reg1p &radic0.39350.91864&radic S000005153SSB2YNL209WverifiedCytoplasmic ATPase that is a ribosome-associated molecularchaperone, functions with J-protein partnerZuo1p; may be involved in the folding ofnewly-synthesized polypeptide chains; member ofthe HSP70 family; homolog of SSB1 &radic0.39490.91864&radic S000000753CUP5YEL027WverifiedProteolipid subunit of the vacuolar H(+)-ATPase V0 sector(subunit c; dicyclohexylcarbodiimide bindingsubunit); required for vacuolar acidificationand important for copper and iron metal ionhomeostasis 0.392940.91693&radic S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.392550.91644&radic&radic&radic&radic&radic&radic&radic S000006003MOT1YPL082CverifiedEssential abundant protein involved in regulation oftranscription, removes Spt15p (TBP) from DNAvia its C-terminal ATPase activity, forms acomplex with TBP that binds TATA DNA with highaffinity but with altered specificity &radic0.391670.91644&radic&radic&radic&radic&radic S000003730CDC6YJL194WverifiedEssential ATP-binding protein required for DNA replication,component of the pre-replicative complex(pre-RC) which requires ORC to associate withchromatin and is in turn required for Mcm2-7pDNA association; homologous to S. pombe Cdc18p &radic0.390240.91644&radic&radic&radic&radic&radic S000001106SSZ1YHR064CverifiedHsp70 protein that interacts with Zuo1p (a DnaJ homolog) toform a ribosome-associated complex that bindsthe ribosome via the Zuo1p subunit; alsoinvolved in pleiotropic drug resistance viasequential activation of PDR1 and PDR5; bindsATP 0.38860.91557&radic&radic S000000974BRR2YER172CverifiedRNA-dependent ATPase RNA helicase involved in the facilitationand disruption of snRNA interactions, requiredfor disruption of U4/U6 base-pairing in nativesnRNPs to activate the spliceosome forcatalysis &radic0.386180.91557&radic&radic&radic S000001812YKR104WVerifiedPutative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds &radic0.387070.91557&radic S000001732DBP7YKR024CverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in ribosomal biogenesis &radic0.383760.91541&radic&radic&radic&radic&radic S000000499PCA1YBR295WverifiedCadmium transporting P-type ATPase; may also have a role incopper and iron homeostasis; S288C and mostother lab strains contain a G970R mutationwhich eliminates normal cadmium transportfunction &radic0.383530.91541&radic S000005321DBP6YNR038WverifiedEssential protein involved in ribosome biogenesis; putativeATP-dependent RNA helicase of the DEAD-boxprotein family &radic0.383010.91541&radic S000000171SSA3YBL075CverifiedATPase involved in protein folding and the response to stress;plays a role in SRP-dependent cotranslationalprotein-membrane targeting and translocation;member of the heat shock protein 70 (HSP70)family; localized to the cytoplasm &radic0.379490.91465&radic&radic&radic&radic&radic&radic S000000897RAD51YER095WverifiedStrand exchange protein, forms a helical filament with DNA thatsearches for homology; involved in therecombinational repair of double-strand breaksin DNA during vegetative growth and meiosis;homolog of Dmc1p and bacterial RecA protein &radic0.377510.91246&radic&radic S000002319DHH1YDL160CverifiedCytoplasmic DExD/H-box helicase, stimulates mRNA decapping,coordinates distinct steps in mRNA function anddecay, interacts with both the decapping anddeadenylase complexes, may have a role in mRNAexport and translation 0.379160.91246&radic&radic S000006156RVB2YPL235WverifiedEssential protein involved in transcription regulation;component of chromatin remodeling complexes;required for assembly and function of the INO80complex; member of the RUVB-like protein family &radic0.376510.91244&radic&radic&radic S000004903HAS1YMR290CverifiedATP-dependent RNA helicase; localizes to both the nuclearperiphery and nucleolus; highly enriched innuclear pore complex fractions; constituent of66S pre-ribosomal particles &radic0.376720.91244&radic&radic&radic&radic&radic&radic S000002344TFP1YDL185WverifiedVacuolar ATPase V1 domain subunit A containing the catalyticnucleotide binding sites; protein precursorundergoes self-catalyzed splicing to yield theextein Tfp1p and the intein Vde (PI-SceI),which is a site-specific endonuclease &radic0.3770.91244 S000004802SGS1YMR190CverifiedNucleolar DNA helicase of the RecQ family involved inmaintenance of genome integrity, regulateschromosome synapsis and meiotic crossing over;has similarity to human BLM and WRN helicasesimplicated in Bloom and Werner syndromes &radic0.374560.91136&radic&radic&radic&radic&radic&radic&radic S000005294PRP2YNR011CverifiedRNA-dependent ATPase in the DEAH-box family, required foractivation of the spliceosome before the firsttransesterification step in RNA splicing &radic0.373650.91035&radic&radic S000001556LHS1YKL073WverifiedMolecular chaperone of the endoplasmic reticulum lumen,involved in polypeptide translocation andfolding; member of the Hsp70 family; localizesto the lumen of the ER; regulated by theunfolded protein response pathway 0.372390.90769&radic S000003674TIF2YJL138CverifiedTranslation initiation factor eIF4A, identical to Tif1p;DEA(D/H)-box RNA helicase that couples ATPaseactivity to RNA binding and unwinding; forms adumbbell structure of two compact domainsconnected by a linker; interacts with eIF4G 0.372360.90769&radic&radic&radic&radic&radic S000000291RFC5YBR087WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon &radic0.371650.90765&radic S000005620ARF3YOR094WverifiedGlucose-repressible ADP-ribosylation factor, GTPase of the Rassuperfamily involved in development of polarity &radic0.371910.90765&radic&radic&radic&radic S000004266DBP9YLR276CverifiedATP-dependent RNA helicase of the DEAD-box family involved inbiogenesis of the 60S ribosomal subunit &radic0.365480.90476&radic&radic&radic&radic&radic S000002666HSP78YDR258CverifiedOligomeric mitochondrial matrix chaperone that cooperates withSsc1p in mitochondrial thermotolerance afterheat shock; prevents the aggregation ofmisfolded matrix proteins; component of themitochondrial proteolysis system &radic0.365570.90476&radic&radic&radic&radic&radic&radic&radic S000005816SNF2YOR290CverifiedCatalytic subunit of the SWI/SNF chromatin remodeling complexinvolved in transcriptional regulation;contains DNA-stimulated ATPase activity;functions interdependently in transcriptionalactivation with Snf5p and Snf6p &radic0.364290.90476&radic&radic&radic S000001405SSL2YIL143CverifiedComponent of the holoenzyme form of RNA polymerasetranscription factor TFIIH, has DNA-dependentATPase/helicase activity and is required, withRad3p, for unwinding promoter DNA; involved inDNA repair; homolog of human ERCC3 0.369840.90476&radic S000000905SSA4YER103WverifiedHeat shock protein that is highly induced upon stress; plays arole in SRP-dependent cotranslationalprotein-membrane targeting and translocation;member of the HSP70 family; cytoplasmic proteinthat concentrates in nuclei upon starvation &radic0.367230.90476&radic&radic S000002189DBP10YDL031WverifiedPutative ATP-dependent RNA helicase of the DEAD-box proteinfamily, constituent of 66S pre-ribosomalparticles; essential protein involved inribosome biogenesis &radic0.36360.90446 S000005659EFT1YOR133WverifiedElongation factor 2 (EF-2), also encoded by EFT2; catalyzesribosomal translocation during proteinsynthesis; contains diphthamide, the uniqueposttranslationally modified histidine residuespecifically ADP-ribosylated by diphtheriatoxin 0.363290.90362&radic&radic&radic&radic S000002500DNF2YDR093WverifiedAminophospholipid translocase (flippase) that localizesprimarily to the plasma membrane; contributesto endocytosis, protein transport and cellpolarity; type 4 P-type ATPase &radic0.358650.90333&radic&radic&radic&radic&radic S000004735ECM16YMR128WverifiedEssential DEAH-box ATP-dependent RNA helicase specific to theU3 snoRNP, predominantly nucleolar indistribution, required for 18S rRNA synthesis 0.352410.90018&radic S000002700SRP101YDR292CverifiedSignal recognition particle (SRP) receptor - alpha subunit;contain GTPase domains; involved inSRP-dependent protein targeting; interacts withSRP102p 0.350370.89825&radic&radic&radic&radic&radic S000006161HSP82YPL240CverifiedCytoplasmic chaperone (Hsp90 family) required for pheromonesignaling and negative regulation of Hsf1p;docks with the mitochondrial import receptorTom70p for preprotein delivery; interacts withco-chaperones Cns1p, Cpr6p, Cpr7p, and Sti1p &radic0.34440.89593&radic&radic&radic&radic&radic&radic S000001709VPS1YKR001CverifiedGTPase required for vacuolar protein sorting, functions inactin cytoskeleton organization via itsinteraction with Sla1p; required for lateGolgi-retention of some proteins includingKex2p; involved in regulating peroxisomebiogenesis &radic0.34080.89593&radic&radic&radic&radic S000000756ECM10YEL030WverifiedHeat shock protein of the Hsp70 family, localized inmitochondrial nucleoids, plays a role inprotein translocation, interacts with Mge1p inan ATP-dependent manner; overexpression inducesextensive mitochondrial DNA aggregations 0.344860.89593&radic&radic&radic&radic&radic&radic&radic S000004625MSS1YMR023CverifiedMitochondrial protein, forms a heterodimer complex with Mto1pthat performs the 5-carboxymethylaminomethylmodification of the wobble uridine base inmitochondrial tRNAs; similar to human GTPBP3 0.339030.89401&radic&radic&radic&radic&radic&radic&radic S000002678CCC2YDR270WverifiedCu(+2)-transporting P-type ATPase, required for export ofcopper from the cytosol into an extracytosoliccompartment; has similarity to human proteinsinvolved in Menkes and Wilsons diseases &radic0.335980.89199&radic&radic S000003088PRP43YGL120CverifiedRNA helicase in the DEAH-box family, functions in both RNApolymerase I and polymerase II transcriptmetabolism, involved in release of thelariat-intron from the spliceosome &radic0.33520.89193 S000003628HPR5YJL092WverifiedDNA helicase and DNA-dependent ATPase involved in DNA repair,required for proper timing of commitment tomeiotic recombination and the transition fromMeiosis I to Meiosis II; potential Cdc28psubstrate 0.334290.89057&radic S000003806SSC1YJR045CverifiedMitochondrial matrix ATPase that is a subunit of thepresequence translocase-associated proteinimport motor (PAM); involved in proteintranslocation into the matrix and proteinfolding; member of the heat shock protein 70(HSP70) family &radic0.334090.89028&radic S000002242SUB2YDL084WverifiedComponent of the TREX complex required for nuclear mRNA export;member of the DEAD-box RNA helicase superfamilyand is involved in early and late steps ofspliceosome assembly; homolog of the humansplicing factor hUAP56 &radic0.333870.89028&radic S000000373SSE2YBR169CverifiedMember of the heat shock protein 70 (HSP70) family; may beinvolved in protein folding; localized to thecytoplasm; highly homologous to the heat shockprotein Sse1p 0.333350.88917&radic&radic&radic S000004772DNF3YMR162CverifiedAminophospholipid translocase (flippase) that maintainsmembrane lipid asymmetry in post-Golgisecretory vessicles; localizes to thetrans-Golgi network; likely involved in proteintransport; type 4 P-type ATPase &radic0.329380.88888&radic&radic&radic&radic&radic S000004798HSC82YMR186WverifiedCytoplasmic chaperone of the Hsp90 family, redundant infunction and nearly identical with Hsp82p, andtogether they are essential; expressedconstitutively at 10-fold higher basal levelsthat HSP82 and induced 2-3 fold by heat shock &radic0.332390.88888&radic&radic&radic&radic&radic&radic&radic&radic S000003924DNM1YLL001WverifiedDynamin-related GTPase required for mitochondrial fission andthe maintenance of mitochondrial morphology,assembles on the cytoplasmic face ofmitochondrial tubules at sites at whichdivision will occur; also participates inendocytosis &radic0.326380.88884&radic&radic&radic&radic S000004096MDN1YLR106CverifiedHuge dynein-related AAA-type ATPase (midasin), forms extendedpre-60S particle with the Rix1 complex(Rix1p-Ipi1p-Ipi3p), may mediate ATP-dependentremodeling of 60S subunits and subsequentexport from nucleoplasm to cytoplasm &radic0.325220.8873&radic&radic&radic&radic&radic&radic S000002651PRP28YDR243CverifiedRNA helicase in the DEAD-box family, involved in RNAisomerization at the 5' splice site &radic0.322510.88649&radic&radic&radic&radic&radic&radic&radic&radic S000004025MLH2YLR035CverifiedProtein required for DNA mismatch repair in mitosis andmeiosis; involved in the repair of mutationalintermediates; forms a complex with Pms1p andMsh1p to repair mismatched DNA 0.322390.88553&radic&radic S000000033FUN12YAL035WverifiedGTPase, required for general translation initiation bypromoting Met-tRNAiMet binding to ribosomes andribosomal subunit joining; homolog of bacterialIF2 &radic0.320290.88528&radic&radic&radic&radic&radic&radic S000006238ARP7YPR034WverifiedActin-related protein involved in transcriptional regulation;subunit of the chromatin remodeling Snf/Swicomplex 0.314880.88283&radic S000000046GEM1YAL048CverifiedEvolutionarily-conserved tail-anchored outer mitochondrialmembrane GTPase which regulates mitochondrialmorphology; cells lacking Gem1p containcollapsed, globular, or grape-likemitochondria; not required forpheromone-induced cell death &radic0.310480.88112&radic&radic&radic S000003067LSG1YGL099WverifiedPutative GTPase involved in 60S ribosomal subunit biogenesis;required for the release of Nmd3p from 60Ssubunits in the cytoplasm &radic0.307190.88047&radic&radic S000003586MTR4YJL050WverifiedDead-box family ATP dependent helicase required for mRNA exportfrom the nucleus; co-factor of the exosomecomplex, required for 3' end formation of 5.8SrRNA &radic0.307280.88047&radic&radic S000000808NUG1YER006WverifiedGTPase that associates with nuclear 60S pre-ribosomes, requiredfor export of 60S ribosomal subunits from thenucleus &radic0.306230.87961&radic&radic&radic&radic S000003882ATP2YJR121WverifiedBeta subunit of the F1 sector of mitochondrial F1F0 ATPsynthase, which is a large, evolutionarilyconserved enzyme complex required for ATPsynthesis 0.305540.87876&radic S000000690CDC50YCR094WverifiedEndosomal protein that regulates cell polarity; similar toYnr048wp and Lem3p &radic0.305160.87876&radic&radic&radic&radic&radic S000002504MSH6YDR097CverifiedProtein required for mismatch repair in mitosis and meiosis,forms a complex with Msh2p to repair bothsingle-base & insertion-deletion mispairs;potentially phosphorylated by Cdc28p &radic0.303130.87814&radic&radic&radic&radic&radic&radic S000002428FAL1YDR021WverifiedNucleolar protein required for maturation of 18S rRNA, memberof the eIF4A subfamily of DEAD-boxATP-dependent RNA helicases &radic0.30240.87797&radic&radic S000001927SMC2YFR031CverifiedComponent of the condensin complex, essential SMC chromosomalATPase family member that forms a complex withSmc4p to form the active ATPase; Smc2p/Smc4pcomplex binds DNA, possibly in the cleft formedby the coiled-coil of the folded dimer &radic0.299020.87737&radic&radic S000002411RAD57YDR004WverifiedProtein that stimulates strand exchange by stabilizing thebinding of Rad51p to single-stranded DNA;involved in the recombinational repair ofdouble-strand breaks in DNA during vegetativegrowth and meiosis; forms heterodimer withRad55p &radic0.299920.87737&radic&radic S000001855ACT1YFL039CverifiedActin, structural protein involved in cell polarization,endocytosis, and other cytoskeletal functions 0.299840.87737&radic&radic&radic S000000315YSA1YBR111CverifiedNudix hydrolase family member with ADP-ribose pyrophosphataseactivity &radic0.298880.87737&radic&radic S000004059MEF1YLR069CverifiedMitochondrial elongation factor involved in translationalelongation 0.297660.87557&radic&radic&radic S000002602MSS116YDR194CverifiedDEAD-box protein required for efficient splicing ofmitochondrial Group I and II introns; non-polarRNA helicase that also facilities strandannealing &radic0.296890.87557&radic&radic&radic&radic S000000822GPA2YER020WverifiedNucleotide binding alpha subunit of the heterotrimeric Gprotein that interacts with the receptor Gpr1p,has signaling role in response to nutrients;green fluorescent protein (GFP)-fusion proteinlocalizes to the cell periphery &radic0.295870.87514&radic S000001794PRP16YKR086WverifiedRNA helicase in the DEAH-box family involved in the secondcatalytic step of splicing, exhibitsATP-dependent RNA unwinding activity &radic0.289260.8719&radic&radic S000004777MLH1YMR167WverifiedProtein required for mismatch repair in mitosis and meiosis,postmeiotic segregation, and spore viability;forms a complex with Pms1p and Msh2p to repairmismatched DNA; human homolog is associatedwith hereditary non-polyposis colon cancer &radic0.289240.8719&radic&radic&radic&radic&radic&radic S000000034RBG1YAL036CverifiedMember of the DRG family of GTP-binding proteins; interactswith translating ribosomes and with Tma46p 0.281280.86732&radic&radic&radic&radic&radic S000003046DBP3YGL078CverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in ribosomal biogenesis &radic0.28120.86732&radic&radic&radic&radic&radic&radic&radic&radic S000004361SSQ1YLR369WverifiedMitochondrial hsp70-type molecular chaperone, required forassembly of iron/sulfur clusters into proteinsat a step after cluster synthesis, and formaturation of Yfh1p, which is a homolog ofhuman frataxin implicated in Friedreich'sataxia 0.278950.86584&radic&radic&radic&radic&radic S000005450MSH2YOL090WverifiedProtein that forms heterodimers with Msh3p and Msh6p that bindto DNA mismatches to initiate the mismatchrepair process; contains a Walker ATP-bindingmotif required for repair activity; Msh2p-Msh6pbinds to and hydrolyzes ATP &radic0.27510.86334&radic&radic S000001064YHR022CUncharacterizedPutative protein of unknown function; YHR022C is not an essential gene. 0.27530.86334&radic S000001762DYN1YKR054CverifiedCytoplasmic heavy chain dynein, microtubule motor protein,required for anaphase spindle elongation;involved in spindle assembly, chromosomemovement, and spindle orientation during celldivision, targeted to microtubule tips by Pac1p 0.272390.86005&radic&radic&radic S000003035NPY1YGL067WverifiedNADH diphosphatase (pyrophosphatase), hydrolyzes thepyrophosphate linkage in NADH and relatednucleotides; localizes to peroxisomes &radic0.26950.85912&radic&radic&radic&radic&radic&radic&radic S000004390SKI2YLR398CverifiedPutative RNA helicase, involved in exosome mediated 3' to 5'mRNA degradation and translation inhibition ofnon-poly(A) mRNAs; forms complex with Ski3p andSki8p; required for repressing propagation ofdsRNA viruses 0.263530.85634&radic&radic&radic&radic S000000815PRP22YER013WverifiedDEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase,associates with lariat intermediates before thesecond catalytic step of splicing; mediatesATP-dependent mRNA release from the spliceosomeand unwinds RNA duplexes &radic0.261050.85574&radic&radic&radic&radic&radic S000003405RBG2YGR173WuncharacterizedProtein with similarity to mammalian developmentally regulatedGTP-binding protein 0.260370.85481&radic&radic&radic&radic&radic S000000390PCH2YBR186WverifiedNucleolar component of the pachytene checkpoint, which preventschromosome segregation when recombination andchromosome synapsis are defective; alsorepresses meiotic interhomolog recombination inthe rDNA 0.258510.85383&radic&radic&radic&radic&radic S000000768GDA1YEL042WverifiedGuanosine diphosphatase located in the Golgi, involved in thetransport of GDP-mannose into the Golgi lumenby converting GDP to GMP after mannose istransferred its substrate &radic0.257120.85321&radic&radic&radic&radic&radic S000000441PRP5YBR237WverifiedRNA helicase in the DEAD-box family, necessary forprespliceosome formation, bridges U1 and U2snRNPs and enables stable U2 snRNP associationwith intron RNA &radic0.255860.85293&radic&radic&radic&radic&radic S000003931DRS1YLL008WverifiedNucleolar DEAD-box protein required for ribosome assembly andfunction, including synthesis of 60S ribosomalsubunits; constituent of 66S pre-ribosomalparticles &radic0.254240.85168&radic&radic&radic&radic S000005336NOG2YNR053CverifiedPutative GTPase that associates with pre-60S ribosomal subunitsin the nucleolus and is required for theirnuclear export and maturation &radic0.252970.85098&radic S000003139ROK1YGL171WverifiedATP-dependent RNA helicase of the DEAD box family; required for18S rRNA synthesis &radic0.249720.84839&radic S000000807YND1YER005WverifiedApyrase with wide substrate specificity, involved in preventingthe inhibition of glycosylation by hydrolyzingnucleoside tri- and diphosphates which areinhibitors of glycotransferases; partiallyredundant with Gda1p &radic0.249460.84839&radic&radic&radic&radic&radic&radic S000006040DBP1YPL119CverifiedPutative ATP-dependent RNA helicase of the DEAD-box proteinfamily; mutants show reduced stability of the40S ribosomal subunit scanning through 5'untranslated regions of mRNAs 0.250460.84839&radic&radic&radic&radic S000002793EFT2YDR385WverifiedElongation factor 2 (EF-2), also encoded by EFT1; catalyzesribosomal translocation during proteinsynthesis; contains diphthamide, the uniqueposttranslationally modified histidine residuespecifically ADP-ribosylated by diphtheriatoxin 0.247570.84615&radic&radic&radic&radic S000004237IRC20YLR247CuncharacterizedPutative helicase; localized to mitochondria and the nucleus;YLR247C is not an essential gene; null mutantdisplays increased levels of spontaneous Rad52foci 0.244630.84387&radic&radic&radic&radic&radic&radic S000001073RRM3YHR031CverifiedDNA helicase involved in rDNA replication and Ty1transposition; relieves replication fork pausesat telomeric regions; structurally andfunctionally related to Pif1p &radic0.241470.84099&radic&radic&radic&radic&radic&radic&radic&radic S000005267LEM3YNL323WverifiedMembrane protein of the plasma membrane and ER, involved intranslocation of phospholipids andalkylphosphocholine drugs across the plasmamembrane &radic0.239820.83947&radic&radic S000005572DBP5YOR046CverifiedCytoplasmic ATP-dependent RNA helicase of the DEAD-box familyinvolved in mRNA export from the nucleus 0.239450.83881&radic&radic&radic S000005331YNR048WVerifiedProtein proposed to interact with phospholipid translocases, shares similarity to Cdc50p &radic0.235060.8355 S000006085MLH3YPL164CverifiedProtein involved in DNA mismatch repair; forms a complex withMlh1p to promote meiotic crossing-over;mammalian homolog is implicated mammalianmicrosatellite instability 0.233320.83338&radic&radic&radic&radic S000005737MGM1YOR211CverifiedMitochondrial GTPase related to dynamin, present in a complexcontaining Ugo1p and Fzo1p; required for normalmorphology of cristae and for stability ofTim11p; homolog of human OPA1 involved inautosomal dominant optic atrophy &radic0.23250.83239&radic&radic&radic&radic&radic S000003571KAR2YJL034WverifiedATPase involved in protein import into the ER, also acts as achaperone to mediate protein folding in the ERand may play a role in ER export of solubleproteins; regulates the unfolded proteinresponse via interaction with Ire1p &radic0.228460.82994&radic S000004141PCD1YLR151CverifiedPeroxisomal nudix pyrophosphatase with specificity for coenzymeA and CoA derivatives, may function to removepotentially toxic oxidized CoA disulfide fromperoxisomes to maintain the capacity forbeta-oxidation of fatty acids &radic0.224340.82956&radic&radic&radic&radic&radic S000001107RRP3YHR065CverifiedProtein involved in rRNA processing; required for maturation ofthe 35S primary transcript of pre-rRNA and forcleavage leading to mature 18S rRNA; homologousto eIF-4a, which is a DEAD box RNA-dependentATPase with helicase activity &radic0.217080.82557 S000005383IFM1YOL023WverifiedMitochondrial translation initiation factor 2 &radic0.21520.82377&radic&radic&radic&radic S000003837CDC11YJR076CverifiedComponent of the septin ring of the mother-bud neck that isrequired for cytokinesis; septins recruitproteins to the neck and can act as a barrierto diffusion at the membrane, and they comprisethe 10nm filaments seen with EM 0.213550.82171 S000006166YPL245WUncharacterizedHypothetical protein 0.212880.82041&radic&radic S000001602VPH2YKL119CverifiedIntegral membrane protein required for vacuolar H+-ATPase(V-ATPase) function, although not an actualcomponent of the V-ATPase complex; functions inthe assembly of the V-ATPase; localized to theendoplasmic reticulum (ER) 0.211240.81877&radic&radic&radic S000000215IPP1YBR011CverifiedCytoplasmic inorganic pyrophosphatase (PPase), catalyzes therapid exchange of oxygens from Pi with water,highly expressed and essential for viability,active-site residues show identity to thosefrom E. coli PPase &radic0.207640.8172&radic&radic&radic S000004685NAM7YMR080CverifiedATP-dependent RNA helicase of the SFI superfamily, required fornonsense mediated mRNA decay and for efficienttranslation termination at nonsense codons;involved in telomere maintenance &radic0.207220.8172&radic&radic S000005966VPS16YPL045WverifiedSubunit of the homotypic vacuole fusion and vacuole proteinsorting (HOPS) complex; part of the Class C Vpscomplex essential for membrane docking andfusion at both the Golgi-to-endosome andendosome-to-vacuole stages of protein transport 0.206740.81606&radic&radic&radic S000001934IRC5YFR038WuncharacterizedPutative ATPase containing the DEAD/H helicase-related sequencemotif; null mutant displays increased levels ofspontaneous Rad52 foci 0.206540.81527&radic&radic&radic&radic S000004280GUF1YLR289WverifiedMitochondrial GTPase of unknown function, similar to E. colielongation factor-type GTP-binding protein LepAand to LK1236.1 from Caenorhabditis elegans &radic0.201180.81348&radic&radic&radic&radic&radic S000004880PPA2YMR267WverifiedMitochondrial inorganic pyrophosphatase, required formitochondrial function and possibly involved inenergy generation from inorganic pyrophosphate &radic0.197140.80967&radic&radic&radic&radic&radic&radic S000001068PPA1YHR026WverifiedSubunit c'' of the vacuolar ATPase, which functions inacidification of the vacuole; one of threeproteolipid subunits of the V0 domain &radic0.195430.80939 S000002283HNT1YDL125CverifiedAdenosine 5'-monophosphoramidase; interacts physically andgenetically with Kin28p, a CDK and TFIIKsubunit, and genetically with CAK1; member ofthe histidine triad (HIT) superfamily ofnucleotide-binding proteins and similar to Hint 0.190080.80614&radic&radic S000004375SMC6YLR383WverifiedProtein involved in structural maintenance of chromosomes;essential subunit of Mms21-Smc5-Smc6 complex;required for growth, DNA repair,interchromosomal and sister chromatidrecombination; homologous to S. pombe rad18 0.188930.80424&radic&radic S000003032MRH4YGL064CverifiedMitochondrial RNA helicase of the DEAD-box family, plays anessential role in mitochondrial function 0.184850.79793&radic&radic&radic&radic S000004306CDC3YLR314CverifiedComponent of the septin ring of the mother-bud neck that isrequired for cytokinesis; septins recruitproteins to the neck and can act as a barrierto diffusion at the membrane, and they comprisethe 10nm filaments seen with EM 0.184560.79793&radic&radic&radic S000005689DDP1YOR163WverifiedDiadenosine polyphosphate hydrolase, member of the MutT familyof nucleotide hydrolases with high specificityfor diadenosine hexa- and pentaphosphates,required for efficient hydrolysis ofdiphosphorylated inositol polyphosphates &radic0.183070.796&radic&radic&radic&radic&radic&radic S000001006YLF2YHL014CverifiedProtein of unknown function, has weak similarity to E. coliGTP-binding protein gtp1; the authentic,non-tagged protein is detected in highlypurified mitochondria in high-throughputstudies 0.177410.79043&radic&radic&radic&radic&radic&radic&radic S000004260DCS1YLR270WverifiedNon-essential hydrolase involved in mRNA decapping, mayfunction in a feedback mechanism to regulatedeadenylation, contains pyrophosphataseactivity and a HIT (histidine triad) motif;interacts with neutral trehalase Nth1p &radic0.177040.79031&radic&radic&radic&radic&radic&radic&radic&radic&radic S000002579SUP35YDR172WverifiedTranslation termination factor eRF3; altered proteinconformation creates the [PSI(+)] prion, adominant cytoplasmically inherited proteinaggregate that alters translational fidelityand creates a nonsense suppressor phenotype 0.176090.78875&radic&radic&radic&radic&radic S000004636ARP9YMR033WverifiedActin-related protein involved in transcriptional regulation;subunit of the chromatin remodeling Snf/Swicomplex 0.175680.78795&radic S000001767TIF1YKR059WverifiedTranslation initiation factor eIF4A, identical to Tif2p;DEA(D/H)-box RNA helicase that couples ATPaseactivity to RNA binding and unwinding; forms adumbbell structure of two compact domainsconnected by a linker; interacts with eIF4G &radic0.175350.78795&radic&radic&radic&radic&radic&radic S000001561DHR2YKL078WverifiedPredominantly nucleolar DEAH-box RNA helicase, required for 18SrRNA synthesis 0.174970.78667&radic&radic&radic&radic&radic S000001500HCS1YKL017CverifiedHexameric DNA polymerase alpha-associated DNA helicase Ainvolved in lagging strand DNA synthesis;contains single-stranded DNA stimulated ATPaseand dATPase activities; replication protein Astimulates helicase and ATPase activities &radic0.173550.78558&radic&radic&radic&radic&radic&radic S000000229YBR025CUncharacterizedHypothetical protein 0.172870.78443&radic&radic&radic S000000431MCX1YBR227CverifiedMitochondrial ATP-binding protein, possibly a mitochondrialchaperone with non-proteolytic function;similar to bacterial ClpX proteins 0.172690.78343&radic&radic&radic&radic S000003059NBP35YGL091CverifiedEssential P-loop NTPase that functions in nuclear and cytosoliciron-sulfur (FeS) protein assembly; has ahighly conserved N-terminus &radic0.171950.78343&radic&radic&radic&radic&radic&radic S000003395GTR2YGR163WverifiedCytoplasmic GTP binding protein that negatively regulatesRan/Tc4 GTPase cycle; subunit of EGO complex,which is involved in microautophagy regulation,and of GSE complex, required for sorting ofGap1p; homolog of human RagC and RagD &radic0.17080.78307 S000004658STV1YMR054WverifiedSubunit of vacuolar-ATPase V0 domain, one of two isoforms(Stv1p and Vph1p); Stv1p is located in V-ATPasecomplexes of the Golgi and endosomes whileVph1p is located in V-ATPase complexes of thevacuole &radic0.16760.78045 S000006292SRP54YPR088CverifiedSignal recognition particle (SRP) subunit (homolog of mammalianSRP54); contains the signal sequence-bindingactivity of SRP, interacts with the SRP RNA,and mediates binding of SRP to signal receptor;contains GTPase domain 0.167450.77982 S000003954GPI13YLL031CverifiedER membrane localized phosphoryltransferase that addsphosphoethanolamine onto the third mannoseresidue of the glycosylphosphatidylinositol(GPI) anchor precursor; similar to human PIG-Oprotein 0.167120.77934&radic&radic&radic&radic&radic S000002187ARP2YDL029WverifiedEssential component of the Arp2/3 complex, which is a highlyconserved actin nucleation center required forthe motility and integrity of actin patches;involved in endocytosis and membrane growth andpolarity 0.166060.77743&radic S000005194RAD50YNL250WverifiedSubunit of MRX complex, with Mre11p and Xrs2p, involved inprocessing double-strand DNA breaks invegetative cells, initiation of meiotic DSBs,telomere maintenance, and nonhomologous endjoining &radic0.165870.77743&radic&radic S000003826ARP3YJR065CverifiedEssential component of the Arp2/3 complex, which is a highlyconserved actin nucleation center required forthe motility and integrity of actin patches;involved in endocytosis and membrane growth andpolarity 0.160130.77 S000003638MEF2YJL102WverifiedMitochondrial elongation factor involved in translationalelongation 0.159030.768 S000005699DCS2YOR173WverifiedNon-essential, stress induced regulatory protein containing aHIT (histidine triad) motif; modulatesm7G-oligoribonucleotide metabolism; inhibitsDcs1p; regulated by Msn2p, Msn4p, and theRas-cAMP-cAPK signaling pathway, similar toDcs1p. &radic0.157290.76686&radic&radic&radic&radic S000002384SHS1YDL225WverifiedOne of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p,Shs1p) that form a cortical filamentous collarat the mother-bud neck which is necessary fornormal morphogenesis and cytokinesis 0.157210.76597 S000002544RGP1YDR137WverifiedSubunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) thatcatalyzes nucleotide exchange on Ypt6p 0.155230.76411&radic&radic&radic&radic S000002740IRC3YDR332WuncharacterizedHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 0.155160.76304&radic&radic&radic&radic&radic&radic S000005182KEX2YNL238WverifiedSubtilisin-like protease (proprotein convertase), acalcium-dependent serine protease involved inthe activation of proproteins of the secretorypathway 0.15510.76304&radic&radic&radic&radic&radic&radic S000004411YLR419WUncharacterizedPutative helicase with limited sequence similarity to human Rb protein; localized to the cytoplasm and the mitochondria; YLR419W is not an essential gene 0.154220.76065&radic&radic S000006155TFP3YPL234CverifiedVacuolar ATPase V0 domain subunit c', involved in protontransport activity; hydrophobic integralmembrane protein (proteolipid) containing fourtransmembrane segments; N and C termini are inthe vacuolar lumen &radic0.152710.75883&radic&radic&radic S000003617ARP4YJL081CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes &radic0.15180.75845&radic S000001047GPA1YHR005CverifiedGTP-binding alpha subunit of the heterotrimeric G protein thatcouples to pheromone receptors; negativelyregulates the mating pathway by sequesteringG(beta)gamma and by triggering an adaptiveresponse; activates Vps34p at the endosome &radic0.151270.75826&radic S000002699HRQ1YDR291WuncharacterizedPutative DNA helicase 0.149920.755&radic&radic&radic&radic&radic&radic S000006038IDI1YPL117CverifiedIsopentenyl diphosphate:dimethylallyl diphosphate isomerase(IPP isomerase), catalyzes an essentialactivation step in the isoprenoid biosyntheticpathway; required for viability 0.149820.75452&radic&radic&radic&radic&radic&radic&radic&radic S000001601YKL118WDubiousDubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2 0.147590.75041&radic&radic&radic&radic S000001211MTG2YHR168WverifiedPutative GTPase, member of the Obg family; peripheral proteinof the mitochondrial inner membrane thatassociates with the large ribosomal subunit;required for mitochondrial translation,possibly via a role in ribosome assembly &radic0.147110.75041&radic S000001265CFD1YIL003WverifiedHighly conserved, putative P-loop ATPase localized in thecytoplasm; has a potential role in assembly ofiron-sulfur clusters in proteins &radic0.146520.74952 S000004924GAS1YMR307WverifiedBeta-1.3-glucanosyltransferase, required for cell wallassembly; localizes to the cell surface via aglycosylphosphatidylinositol (GPI) anchor 0.146830.74952&radic&radic&radic S000003442YGR210CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.142480.74506&radic&radic S000004334FKS1YLR342WverifiedCatalytic subunit of 1,3-beta-D-glucan synthase, functionallyredundant with alternate catalytic subunitGsc2p; binds to regulatory subunit Rho1p;involved in cell wall synthesis andmaintenance; localizes to sites of cell wallremodeling 0.142240.74465&radic&radic&radic S000005950SUV3YPL029WverifiedATP-dependent RNA helicase, component of the mitochondrialdegradosome along with the RNase Dss1p; thedegradosome associates with the ribosome andmediates turnover of aberrant or unprocessedRNAs &radic0.140690.7431&radic&radic&radic&radic S000004590GTR1YML121WverifiedCytoplasmic GTP binding protein and negative regulator, withhomolog Gtr2p, of the Ran/Tc4 GTPase cycle;component of GSE complex, which is required forsorting of Gap1p; involved in phosphatetransport; has homology to human RagA and RagB &radic0.139960.73995 S000005784HNT3YOR258WverifiedMember of the third branch of the histidine triad (HIT)superfamily of nucleotide-binding proteins;similar to Aprataxin, a Hint related proteinthat is mutated in individuals with ataxia withoculomotor apraxia 0.139880.73995&radic&radic&radic&radic&radic&radic&radic S000003220HFM1YGL251CverifiedMeiosis specific DNA helicase involved in the conversion ofdouble-stranded breaks to later recombinationintermediates and in crossover control;catalyzes the unwinding of Holliday junctions;has ssDNA and dsDNA stimulated ATPase activity 0.139150.73781&radic&radic&radic&radic&radic S000001891MSH4YFL003CverifiedProtein involved in meiotic recombination, required for normallevels of crossing over, colocalizes with Zip2pto discrete foci on meiotic chromosomes, hashomology to bacterial MutS protein 0.13760.73477&radic S000001102VMA22YHR060WverifiedIntegral membrane protein that is required for vacuolarH+-ATPase (V-ATPase) function, although not anactual component of the V-ATPase complex;functions in the assembly of the V-ATPase;localized to the yeast endoplasmic reticulum(ER) 0.13570.73081&radic&radic&radic&radic&radic&radic S000005713TUF1YOR187WverifiedMitochondrial translation elongation factor Tu; comprises bothGTPase and guanine nucleotide exchange factoractivities, while these activities are found inseparate proteins in S. pombe and humans &radic0.134320.72912&radic&radic&radic S000001243RPN10YHR200WverifiedNon-ATPase base subunit of the 19S regulatory particle (RP) ofthe 26S proteasome; N-terminus plays a role inmaintaining the structural integrity of the RP;binds selectively to polyubiquitin chains;homolog of the mammalian S5a protein 0.13410.72803&radic&radic&radic&radic S000003903YJR142WUncharacterizedPutative protein of unknown function 0.129750.72328&radic S000004075ARP6YLR085CverifiedActin-related protein that binds nucleosomes; a component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.129690.72059&radic&radic&radic&radic&radic&radic S000002744YDR336WUncharacterizedPutative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene 0.124870.71627&radic&radic&radic&radic&radic&radic S000003337VMA21YGR105WverifiedIntegral membrane protein that is required for vacuolarH+-ATPase (V-ATPase) function, although not anactual component of the V-ATPase complex;functions in the assembly of the V-ATPase;localized to the yeast endoplasmic reticulum(ER) 0.12470.71627&radic&radic&radic&radic S000003503SLH1YGR271WverifiedPutative RNA helicase related to Ski2p, involved in translationinhibition of non-poly(A) mRNAs; required forrepressing propagation of dsRNA viruses 0.124250.71491&radic S000000827GCD11YER025WverifiedGamma subunit of the translation initiation factor eIF2,involved in the identification of the startcodon; binds GTP when forming the ternarycomplex with GTP and tRNAi-Met 0.121440.71225&radic&radic&radic S000005394SMC5YOL034WverifiedStructural maintenance of chromosomes (SMC) protein; essentialsubunit of the Mms21-Smc5-Smc6 complex;required for growth and DNA repair; S. pombehomolog forms a heterodimer with S. pombeRad18p that is involved in DNA repair 0.120010.71021&radic&radic&radic&radic&radic S000002151YBL111CUncharacterizedHelicase-like protein encoded within the telomeric Y' element 0.118430.70621 S000006284TEF1YPR080WverifiedTranslational elongation factor EF-1 alpha; also encoded byTEF2; functions in the binding reaction ofaminoacyl-tRNA (AA-tRNA) to ribosomes 0.118570.70621&radic S000005667ARP8YOR141CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes &radic0.116480.70497&radic&radic&radic&radic S000005026PMS1YNL082WverifiedATP-binding protein required for mismatch repair in mitosis andmeiosis; functions as a heterodimer with Mlh1p,binds double- and single-stranded DNA via itsN-terminal domain, similar to E. coli MutL &radic0.115720.70311&radic&radic&radic S000000741EDC3YEL015WverifiedNon-essential conserved protein of unknown function, plays arole in mRNA decapping by specificallyaffecting the function of the decapping enzymeDcp1p; localizes to cytoplasmic mRNA processingbodies 0.115910.70311&radic&radic&radic S000005433THP1YOL072WverifiedNuclear pore-associated protein, forms a complex with Sac3pthat is involved in transcription and in mRNAexport from the nucleus; contains a PAM domainimplicated in protein-protein binding 0.115130.70076&radic&radic&radic S000000195ATP1YBL099WverifiedAlpha subunit of the F1 sector of mitochondrial F1F0 ATPsynthase, which is a large, evolutionarilyconserved enzyme complex required for ATPsynthesis 0.114840.70076 S000003355PPT1YGR123CverifiedProtein serine/threonine phosphatase with similarity to humanphosphatase PP5; present in both the nucleusand cytoplasm; expressed during logarithmicgrowth 0.110480.69406&radic&radic&radic&radic&radic&radic&radic S000002313MSH5YDL154WverifiedProtein of the MutS family, forms a dimer with Msh4p thatfacilitates crossovers between homologs duringmeiosis; msh5-Y823H mutation confers toleranceto DNA alkylating agents; homologs present inC. elegans and humans 0.108820.69229&radic S000005283YRF1-6YNL339CverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p 0.107860.69029&radic&radic&radic&radic S000001695SAC1YKL212WverifiedLipid phosphoinositide phosphatase of the ER and Golgi,involved in protein trafficking and secretion 0.107920.69029&radic&radic&radic&radic S000005107RIA1YNL163CverifiedCytoplasmic GTPase involved in biogenesis of the 60S ribosome;has similarity to translation elongation factor2 (Eft1p and Eft2p) &radic0.103820.68574&radic&radic&radic&radic&radic S000001656SNU114YKL173WverifiedGTPase component of U5 snRNP involved in mRNA splicing viaspliceosome; binds directly to U5 snRNA;proposed to be involved in conformationalchanges of the spliceosome; similarity toribosomal translocation factor EF-2 &radic0.102590.68423&radic&radic&radic&radic&radic S000005032TOP2YNL088WverifiedEssential type II topoisomerase, relieves torsional strain inDNA by cleaving and re-sealing thephosphodiester backbone of both positively andnegatively supercoiled DNA; cleavescomplementary strands; localizes to axial coresin meiosis 0.102110.68192&radic&radic S000003670LCB3YJL134WverifiedLong-chain base-1-phosphate phosphatase, regulates ceramide andlong-chain base phosphates levels, involved inincorporation of exogenous long chain bases insphingolipids 0.094880.6713&radic&radic S000005248YPT11YNL304WverifiedRab-type small GTPase that interacts with the C-terminal taildomain of Myo2p to mediate distribution ofmitochondria to daughter cells &radic0.094810.67103&radic&radic&radic&radic&radic&radic S000000978ECM32YER176WverifiedDNA dependent ATPase/DNA helicase belonging to the Dna2p- andNam7p-like family of helicases that is involvedin modulating translation termination;interacts with the translation terminationfactors, localized to polysomes 0.092820.66758&radic S000000973RAD3YER171Wverified5' to 3' DNA helicase, involved in nucleotide excision repairand transcription; subunit of RNA polymerase IItranscription initiation factor TFIIH; subunitof Nucleotide Excision Repair Factor 3 (NEF3);homolog of human XPD protein 0.092660.66699&radic&radic S000002178RPN4YDL020CverifiedTranscription factor that stimulates expression of proteasomegenes; Rpn4p levels are in turn regulated bythe 26S proteasome in a negative feedbackcontrol mechanism; RPN4 is transcriptionallyregulated by various stress responses 0.091580.66405&radic&radic&radic S000000065RFA1YAR007CverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 0.090480.66062&radic&radic&radic&radic&radic S000006366ORC4YPR162CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing 0.087810.65688&radic&radic&radic S000004494RAD52YML032CverifiedProtein that stimulates strand exchange by facilitating Rad51pbinding to single-stranded DNA; annealscomplementary single-stranded DNA; involved inthe repair of double-strand breaks in DNAduring vegetative growth and meiosis 0.086850.65461&radic&radic&radic S000004093CDC45YLR103CverifiedDNA replication initiation factor; recruited to MCM pre-RCcomplexes at replication origins; promotesrelease of MCM from Mcm10p, recruits elongationmachinery; mutants in human homolog may causevelocardiofacial and DiGeorge syndromes 0.085640.65229&radic&radic&radic&radic&radic&radic&radic S000005602SKI7YOR076CverifiedAntiviral adaptor protein that mediates interactions via itsN-terminus between the exosome and Ski complex(Ski2p, Ski3p, Ski8p) which operate in the3'-to-5' mRNA-decay pathway; cytoplasmicprotein required for degrading nonstop mRNAs 0.085220.65093&radic&radic&radic S000000605PGK1YCR012Wverified3-phosphoglycerate kinase, catalyzes transfer of high-energyphosphoryl groups from the acyl phosphate of1,3-bisphosphoglycerate to ADP to produce ATP;key enzyme in glycolysis and gluconeogenesis 0.082950.64823&radic&radic&radic&radic&radic&radic&radic S000005004ARP5YNL059CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes &radic0.081330.64496&radic&radic S000001171ARP1YHR129CverifiedActin-related protein of the dynactin complex; required forspindle orientation and nuclear migration;putative ortholog of mammalian centractin 0.080720.6437&radic&radic&radic&radic&radic S000000992YRF1-2YER190WverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p 0.08030.64262&radic S000002938APA2YDR530CverifiedDiadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4Aphosphorylase), involved in catabolism ofbis(5'-nucleosidyl) tetraphosphates; hassimilarity to Apa1p &radic0.078480.63934&radic&radic S000000021PMT2YAL023CverifiedProtein O-mannosyltransferase, transfers mannose residues fromdolichyl phosphate-D-mannose to proteinserine/threonine residues; acts in a complexwith Pmt1p, can instead interact with Pmt5p insome conditions; target for new antifungals 0.077950.63639&radic&radic&radic S000001933RSC8YFR037CverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; essential for viability andmitotic growth; homolog of SWI/SNF subunitSwi3p, but unlike Swi3p, does not activatetranscription of reporters 0.077510.63639&radic&radic&radic&radic&radic S000004339KAP95YLR347CverifiedKaryopherin beta, forms a dimeric complex with Srp1p (Kap60p)that mediates nuclear import of cargo proteinsvia a nuclear localization signal (NLS),interacts with nucleoporins to guide transportacross the nuclear pore complex 0.077120.63507&radic&radic&radic S000001162MSH1YHR120WverifiedDNA-binding protein of the mitochondria involved in repair ofmitochondrial DNA, has ATPase activity andbinds to DNA mismatches; has homology to E.coli MutS; transcription is induced duringmeiosis &radic0.076860.63488&radic&radic&radic&radic&radic S000004703MTG1YMR097CverifiedPeripheral GTPase of the mitochondrial inner membrane,essential for respiratory competence, likelyfunctions in assembly of the large ribosomalsubunit, has homologs in plants and animals &radic0.076640.63488&radic S000003399CLC1YGR167WverifiedClathrin light chain, subunit of the major coat proteininvolved in intracellular protein transport andendocytosis; thought to regulate clathrinfunction, two Clathrin heavy chains (CHC1) formthe clathrin triskelion structural component 0.076250.63333&radic&radic&radic&radic&radic&radic S000000823RPN3YER021WverifiedEssential, non-ATPase regulatory subunit of the 26S proteasomelid, similar to the p58 subunit of the human26S proteasome; temperature-sensitive allelescause metaphase arrest, suggesting a role forthe proteasome in cell cycle control 0.075190.63006&radic&radic&radic S000002604YDR196CUncharacterizedpredicted to catalyze the final step in synthesis of Coenzyme A 0.074880.62784&radic&radic&radic&radic&radic S000001160ORC6YHR118CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing; may be phosphorylated by Cdc28p 0.073120.62441&radic&radic&radic&radic&radic&radic&radic S000001852YFL042CUncharacterizedPutative protein of unknown function; YFL042C is not an essential gene 0.073310.62441&radic&radic S000000555APA1YCL050CverifiedDiadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4Aphosphorylase), involved in catabolism ofbis(5'-nucleosidyl) tetraphosphates; hassimilarity to Apa2p &radic0.071780.62306&radic&radic&radic&radic&radic S000004556RPM2YML091CverifiedProtein component of mitochondrial RNase P, along with themitochondrially-encoded RNA subunit RPM1; RnaseP removes 5' extensions from tRNA precursors;Rpm2p is also involved in maturation of RPM1and in translation of mitochondrial mRNAs 0.072240.62306 S000002835RPN9YDR427WverifiedNon-ATPase regulatory subunit of the 26S proteasome, hassimilarity to putative proteasomal subunits inother species; null mutant is temperaturesensitive and exhibits cell cycle andproteasome assembly defects 0.071260.62138&radic&radic S000005770ESA1YOR244WverifiedHistone acetyltransferase catalytic subunit of the nativemultisubunit complex (NuA4) that acetylatesfour conserved internal lysines of histone H4N-terminal tail; required for cell cycleprogression 0.070010.61764&radic&radic&radic&radic&radic&radic&radic S000000172ILS1YBL076CverifiedCytoplasmic isoleucine-tRNA synthetase, target of theG1-specific inhibitor reveromycin A 0.070640.61764&radic&radic&radic&radic S000000147PIN4YBL051CverifiedProtein involved in G2/M phase progression and response to DNAdamage, interacts with Rad53p; contains an RNArecognition motif, a nuclear localizationsignal, and several SQ/TQ cluster domains;hyperphosphorylated in response to DNA damage 0.067280.61039&radic&radic&radic&radic&radic&radic S000005990BTS1YPL069CverifiedGeranylgeranyl diphosphate synthase, increases theintracellular pool of geranylgeranyldiphosphate, suppressor of bet2 mutation thatcauses defective geranylgeranylation of smallGTP-binding proteins that mediate vesiculartraffic 0.066320.60563&radic&radic&radic S000001391TAO3YIL129CverifiedProtein involved in cell morphogenesis and proliferation,associated with protein kinase Cbk1p; mutantsactivate OCH1 transcription 0.066790.60563&radic S000004364SUR4YLR372WverifiedElongase, involved in fatty acid and sphingolipid biosynthesis;synthesizes very long chain 20-26-carbon fattyacids from C18-CoA primers; involved inregulation of sphingolipid biosynthesis 0.066420.60563&radic&radic&radic&radic S000001487AUR1YKL004WverifiedPhosphatidylinositol:ceramide phosphoinositol transferase (IPCsynthase), required for sphingolipid synthesis;can mutate to confer aureobasidin A resistance 0.066180.60563&radic&radic S000003990YLL067CUncharacterizedPutative protein of unknown function with similarity to helicases 0.066510.60563 S000001439YIL177CUncharacterizedPutative protein of unknown function; similarity to DNA helicases that are encoded within subtelomeric Y' elements and induced in telomerase deficient survivors 0.064780.60277 S000004602YML133CUncharacterizedPutative protein of unknown function with similarity to helicases; localized to mitochondria; YML133C contains an intron 0.065010.60277 S000004224TOP3YLR234WverifiedDNA Topoisomerase III, conserved protein that functions in acomplex with Sgs1p and Rmi1p to relaxsingle-stranded negatively-supercoiled DNApreferentially, involved in telomere stabilityand regulation of mitotic recombination 0.064680.60277&radic&radic&radic&radic&radic&radic&radic S000002953YRF1-1YDR545WverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p 0.064510.60148 S000003989YLL066CUncharacterizedPutative protein of unknown function with similarity to helicases; YLL066C is not an essential gene 0.064490.60148 S000001261YHR218WUncharacterizedHelicase-like protein encoded within the telomeric Y' element 0.064140.59979&radic&radic S000003291SPR3YGR059WverifiedSporulation-specific homolog of the yeast CDC3/10/11/12 familyof bud neck microfilament genes; septin proteininvolved in sporulation; regulated by ABFI 0.064270.59979&radic&radic&radic S000001948RPN12YFR052WverifiedSubunit of the 19S regulatory particle of the 26S proteasomelid; synthetically lethal with RPT1, which isan ATPase component of the 19S regulatoryparticle; physically interacts with Nob1p andRpn3p 0.063390.59705&radic&radic&radic&radic S000000938GDI1YER136WverifiedGDP dissociation inhibitor, regulates vesicle traffic insecretory pathways by regulating thedissociation of GDP from the Sec4/Ypt/rabfamily of GTP binding proteins 0.063290.59705&radic S000003454PET54YGR222WverifiedProtein required for splicing of the COX1 intron AI5 beta; alsospecifically required, together with Pet122pand Pet494p, for translation of the COX3 mRNA;located in the mitochondrial inner membrane 0.062740.59532&radic&radic&radic&radic&radic&radic S000001792HBS1YKR084CverifiedGTP binding protein with sequence similarity to the elongationfactor class of G proteins, EF-1alpha andSup35p; associates with Dom34p, and shares asimilar genetic relationship with genes thatencode ribosomal protein components 0.062120.59215&radic&radic&radic&radic S000005266KRE1YNL322CverifiedCell wall glycoprotein involved in beta-glucan assembly; servesas a K1 killer toxin membrane receptor 0.061870.59215&radic&radic&radic&radic S000003528YRF1-3YGR296WverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p 0.061570.59166 S000002483RAD55YDR076WverifiedProtein that stimulates strand exchange by stabilizing thebinding of Rad51p to single-stranded DNA;involved in the recombinational repair ofdouble-strand breaks in DNA during vegetativegrowth and meiosis; forms heterodimer withRad57p &radic0.061430.59166&radic&radic&radic&radic&radic&radic&radic S000001828YFL066CUncharacterizedHelicase-like protein encoded within the telomeric Y' element 0.059940.58668 S000003927ORC3YLL004WverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing 0.060330.58668&radic&radic&radic&radic&radic S000007526YOR396WUncharacterizedHypothetical protein 0.059810.58567 S000005558HMS1YOR032CverifiedBasic helix-loop-helix (bHLH) protein with similarity tomyc-family transcription factors;overexpression confers hyperfilamentous growthand suppresses the pseudohyphal filamentationdefect of a diploid mep1 mep2 homozygous nullmutant 0.059550.58473&radic&radic S000005562PEP12YOR036WverifiedTarget membrane receptor (t-SNARE) for vesicular intermediatestraveling between the Golgi apparatus and thevacuole; controls entry of biosynthetic,endocytic, and retrograde traffic into theprevacuolar compartment; syntaxin 0.059460.58473&radic&radic&radic S000003760YJL225CUncharacterizedPutative protein of unknown function; similarity to DNA helicases that are also encoded within subtelomeric Y' elements and induced in telomerase deficient survivors 0.05880.58333 S000005607TGL5YOR081CverifiedTriacylglycerol lipase involved in TAG mobilization; localizesto lipid particles; potential Cdc28p substrate 0.058720.58272&radic&radic&radic&radic S000006204YRF1-7YPL283CverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p 0.058570.58206 S000000595CDC10YCR002CverifiedComponent of the septin ring of the mother-bud neck that isrequired for cytokinesis; septins recruitproteins to the neck and can act as a barrierto diffusion at the membrane, and they comprisethe 10nm filaments seen with EM &radic0.05850.58206&radic&radic&radic&radic&radic&radic&radic S000000131POL12YBL035CverifiedB subunit of DNA polymerase alpha-primase complex, required forinitiation of DNA replication during mitoticand premeiotic DNA synthesis; also functions intelomere capping and length regulation 0.058330.58114&radic&radic&radic&radic&radic&radic&radic S000001356LYS12YIL094CverifiedHomo-isocitrate dehydrogenase, an NAD-linked mitochondrialenzyme required for the fourth step in thebiosynthesis of lysine, in whichhomo-isocitrate is oxidatively decarboxylatedto alpha-ketoadipate 0.058160.5808 S000004417TUS1YLR425WverifiedGuanine nucleotide exchange factor (GEF) that functions tomodulate Rho1p activity as part of the cellintegrity signaling pathway; multicopysuppressor of tor2 mutation and ypk1 ypk2double mutation; potential Cdc28p substrate 0.057810.57556 S000006379DPB2YPR175WverifiedSecond largest subunit of DNA polymerase II (DNA polymeraseepsilon), required for normal yeast chromosomalreplication; expression peaks at the G1/S phaseboundary; potential Cdc28p substrate 0.057110.57556&radic&radic&radic S000000322TEF2YBR118WverifiedTranslational elongation factor EF-1 alpha; also encoded byTEF1; functions in the binding reaction ofaminoacyl-tRNA (AA-tRNA) to ribosomes 0.057660.57556&radic S000004459YRF1-5YLR467WverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p 0.057030.57556 S000006014NOG1YPL093WverifiedPutative GTPase that associates with free 60S ribosomalsubunits in the nucleolus and is required for60S ribosomal subunit biogenesis; constituentof 66S pre-ribosomal particles; member of theODN family of nucleolar G-proteins 0.056690.57319&radic&radic S000001715MEH1YKR007WverifiedComponent of the EGO complex, which is involved in theregulation of microautophagy, and of the GSEcomplex, which is required for proper sortingof amino acid permease Gap1p; loss results in adefect in vacuolar acidification 0.056560.57319&radic&radic&radic&radic S000002578HSP42YDR171WverifiedSmall cytosolic stress-induced chaperone that formsbarrel-shaped oligomers and suppresses theaggregation of non-native proteins; oligomerdissociation is not required for function;involved in cytoskeleton reorganization afterheat shock 0.056420.57319&radic&radic&radic&radic&radic&radic&radic&radic S000003963VPS13YLL040CverifiedProtein of unknown function; heterooligomeric or homooligomericcomplex; peripherally associated withmembranes; homologous to human COH1; involvedin sporulation, vacuolar protein sorting andprotein-Golgi retention 0.056510.57319&radic&radic&radic&radic S000002911LPP1YDR503CverifiedLipid phosphate phosphatase, catalyzes Mg(2+)-independentdephosphorylation of phosphatidic acid (PA),lysophosphatidic acid, and diacylglycerolpyrophosphate; involved in control of thecellular levels of phosphatidylinositol and PA 0.055920.57138&radic S000006408YPR204WUncharacterizedHelicase-like protein encoded within the telomeric Y' element 0.05480.56692 S000005922HAT1YPL001WverifiedCatalytic subunit of the Hat1p-Hat2p histone acetyltransferasecomplex that uses the cofactor acetyl coenzymeA, to acetylate free nuclear and cytoplasmichistone H4; involved in telomeric silencing andDNA double-strand break repair 0.054260.56388&radic&radic&radic S000000340MEC1YBR136WverifiedGenome integrity checkpoint protein and PI kinase superfamilymember; signal transducer required for cellcycle arrest and transcriptional responsesprompted by damaged or unreplicated DNA;monitors and participates in meioticrecombination 0.05430.56388 S000000742NPP2YEL016CverifiedNucleotide pyrophosphatase/phosphodiesterase family member;mediates extracellular nucleotide phosphatehydrolysis along with Npp1p and Pho5p; activityand expression enhanced during conditions ofphosphate starvation &radic0.053210.56129&radic&radic&radic S000002703HDA2YDR295CverifiedSubunit of a possibly tetrameric trichostatin A-sensitive classII histone deacetylase complex containing anHda1p homodimer and an Hda2p-Hda3p heterodimer;involved in telomere maintenance 0.053190.56038&radic&radic&radic&radic S000000912KAP123YER110CverifiedKaryopherin beta, mediates nuclear import of ribosomal proteinsprior to assembly into ribosomes and import ofhistones H3 and H4; localizes to the nuclearpore, nucleus, and cytoplasm; exhibits geneticinteractions with RAI1 0.052130.55792&radic&radic S000005256RFA2YNL312WverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 0.051970.55755&radic&radic&radic&radic&radic S000001234CTF8YHR191CverifiedSubunit of a complex with Ctf18p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion 0.051720.55451 S000000621NPP1YCR026CverifiedNucleotide pyrophosphatase/phosphodiesterase family member;mediates extracellular nucleotide phosphatehydrolysis along with Npp2p and Pho5p; activityand expression enhanced during conditions ofphosphate starvation &radic0.05130.55451&radic S000004458YRF1-4YLR466WverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p 0.0510.55333 S000000763RAD23YEL037CverifiedProtein with ubiquitin-like N terminus, recognizes and bindsdamaged DNA (with Rad4p) during nucleotideexcision repair; regulates Rad4p levels,subunit of Nuclear Excision Repair Factor 2(NEF2); homolog of human HR23A and HR23Bproteins 0.050850.5509&radic&radic&radic&radic&radic&radic&radic S000000404BEM1YBR200WverifiedProtein containing SH3-domains, involved in establishing cellpolarity and morphogenesis; functions as ascaffold protein for complexes that includeCdc24p, Ste5p, Ste20p, and Rsr1p 0.050720.5509&radic&radic&radic&radic&radic S000002152YBL112CUncharacterizedPutative protein of unknown function; YBL112C is contained within TEL02L 0.050920.5509 S000002386HOYDL227CverifiedSite-specific endonuclease required for gene conversion at theMAT locus (homothallic switching) through thegeneration of a ds DNA break; expressionrestricted to mother cells in late G1 ascontrolled by Swi4p-Swi6p, Swi5p and Ash1p 0.050260.54918&radic S000003461SMI1YGR229CverifiedProtein involved in the regulation of cell wall synthesis;proposed to be involved in coordinating cellcycle progression with cell wall integrity 0.05020.54918&radic&radic&radic S000005871TYE7YOR344CverifiedSerine-rich protein that contains a basic-helix-loop-helix(bHLH) DNA binding motif; binds E-boxes ofglycolytic genes and contributes to theiractivation; may function as a transcriptionalactivator in Ty1-mediated gene expression 0.049850.54517&radic&radic&radic&radic&radic&radic&radic S000002796RVS167YDR388WverifiedActin-associated protein, subunit of a complex(Rvs161p-Rvs167p) involved in regulation ofactin cytoskeleton, endocytosis, and viabilityfollowing starvation or osmotic stress; homologof mammalian amphiphysin 0.049790.54517&radic&radic&radic&radic&radic&radic S000006409YEL077CUncharacterizedHelicase-like protein encoded within the telomeric Y' element 0.049730.54517 S000002626SPR28YDR218CverifiedSporulation-specific homolog of the yeast CDC3/10/11/12 familyof bud neck microfilament genes; meiotic septinexpressed at high levels during meioticdivisions and ascospore formation 0.04980.54517&radic&radic&radic&radic&radic S000002479IPT1YDR072CverifiedInositolphosphotransferase 1, involved in synthesis ofmannose-(inositol-P)2-ceramide (M(IP)2C), whichis the most abundant sphingolipid in cells,mutation confers resistance to the antifungalssyringomycin E and DmAMP1 in some growth media 0.048970.54321&radic&radic&radic&radic S000001069RPN1YHR027CverifiedNon-ATPase base subunit of the 19S regulatory particle of the26S proteasome; may participate in therecognition of several ligands of theproteasome; contains a leucine-rich repeat(LRR) domain, a site for protein?proteininteractions 0.049020.54321&radic&radic&radic&radic S000002362ACK1YDL203CuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.047760.53866 S000006138BMS1YPL217CverifiedEssential conserved nucleolar GTP-binding protein required forsynthesis of 40S ribosomal subunits and forprocessing of the 35S pre-rRNA at sites A0, A1,and A2; interacts with Rcl1p, has similarity toTsr1p 0.048220.53866 S000004083NYV1YLR093Cverifiedv-SNARE component of the vacuolar SNARE complex involved invesicle fusion; inhibits ATP-dependent Ca(2+)transport activity of Pmc1p in the vacuolarmembrane 0.047930.53866&radic&radic&radic&radic S000003027YGL059WUncharacterizedHypothetical protein 0.048690.53866 S000005788YOR262WUncharacterizedProtein required for cell viability 0.047610.53775&radic&radic&radic&radic&radic S000004036YLR046CUncharacterizedPutative membrane protein, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance 0.046860.53464&radic&radic&radic&radic&radic S000005206POL2YNL262WverifiedCatalytic subunit of DNA polymerase epsilon, one of the majorchromosomal DNA replication polymerasescharacterized by processivity and proofreadingexonuclease activity; also involved in DNAsynthesis during DNA repair 0.047250.53464&radic&radic&radic&radic&radic&radic&radic S000005364SIN3YOL004WverifiedComponent of the Sin3p-Rpd3p histone deacetylase complex,involved in transcriptional repression andactivation of diverse processes, includingmating-type switching and meiosis; involved inthe maintenance of chromosomal integrity 0.047290.53464&radic&radic S000001761YSR3YKR053CverifiedDihydrosphingosine 1-phosphate phosphatase, membrane proteininvolved in sphingolipid metabolism; hassimilarity to Lcb3p 0.046470.53286 S000001164YHR122WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; may be involved in transcription; YHR122W is an essential gene 0.046240.53085&radic&radic&radic&radic&radic&radic S000005527RRP6YOR001WverifiedExonuclease component of the nuclear exosome; contributes tothe quality-control system that retains anddegrades aberrant mRNAs in the nucleus 0.045980.53085&radic&radic&radic&radic S000002161MCD1YDL003WverifiedEssential protein required for sister chromatid cohesion inmitosis and meiosis; subunit of the cohesincomplex; expression is cell cycle regulated andpeaks in S phase 0.045810.52942&radic&radic&radic S000000264ORC2YBR060CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing; may be phosphorylated by Cdc28p 0.045690.52942&radic&radic&radic S000002969ERG26YGL001CverifiedC-3 sterol dehydrogenase, catalyzes the second of three stepsrequired to remove two C-4 methyl groups froman intermediate in ergosterol biosynthesis 0.045510.52822&radic&radic S000000975RAD24YER173WverifiedCheckpoint protein, involved in the activation of the DNAdamage and meiotic pachytene checkpoints;subunit of a clamp loader that loadsRad17p-Mec3p-Ddc1p onto DNA; homolog of humanand S. pombe Rad17 protein &radic0.045150.52764&radic&radic&radic S000001409SLN1YIL147CverifiedHistidine kinase osmosensor that regulates a MAP kinasecascade; transmembrane protein with anintracellular kinase domain that signals toYpd1p and Ssk1p, thereby forming a phosphorelaysystem similar to bacterial two-componentregulators 0.044560.52475&radic S000001909IOC3YFR013WverifiedMember of a complex (Isw1a) with Isw1p that hasnucleosome-stimulated ATPase activity andrepresses transcription initiation by specificpositioning of a promoter proximaldinucleosome; has homology to Esc8p, which isinvolved in silencing 0.044020.52068&radic&radic&radic S000000944MAG1YER142Cverified3-methyl-adenine DNA glycosylase involved in protecting DNAagainst alkylating agents; initiates baseexcision repair by removing damaged bases tocreate abasic sites that are subsequentlyrepaired 0.04390.52068&radic&radic&radic S000000491ZSP1YBR287WuncharacterizedProtein of unknown function; mutation results in a zincsensitive phenotype 0.043270.51832&radic S000001716RSC4YKR008WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; found in close proximity tonucleosomal DNA; displaced from the surface ofnucleosomal DNA after chromatin remodeling 0.042830.51749&radic&radic&radic&radic&radic S000005289VPS27YNR006WverifiedEndosomal protein that forms a complex with Hse1p; required forrecycling Golgi proteins, forming lumenalmembranes and sorting ubiquitinated proteinsdestined for degradation; has UbiquitinInteraction Motifs which bind ubiquitin (Ubi4p) 0.04270.51643 S000004349RSC2YLR357WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; involvedin telomere maintenance 0.04230.51435&radic&radic&radic&radic&radic S000004265SMD2YLR275WverifiedCore Sm protein Sm D2; part of heteroheptameric complex (withSmb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D2 0.042270.51435&radic&radic&radic&radic S000000739VAC8YEL013WverifiedPhosphorylated vacuolar membrane protein that interacts withAtg13p, required for the cytoplasm-to-vacuoletargeting (Cvt) pathway; interacts with Nvj1pto form nucleus-vacuole junctions 0.042070.51375&radic&radic&radic&radic&radic&radic S000007274OLI1Q0130verifiedF0-ATP synthase subunit 9 (ATPase-associated proteolipid),encoded on the mitochondrial genome; mutationconfers oligomycin resistance; expression isspecifically dependent on the nuclear genesAEP1 and AEP2 0.041680.51161 S000001304PKP1YIL042CverifiedMitochondrial kinase, phosphorylates pyruvate dehydrogenasealpha subunit Pda1p 0.041420.5095 S000002545HPR1YDR138WverifiedSubunit of THO/TREX complexes that couple transcriptionelongation with mitotic recombination and withmRNA metabolism and export, subunit of an RNAPol II complex; regulates lifespan; involved intelomere maintenance; similar to Top1p 0.041220.5095&radic&radic&radic&radic&radic&radic S000005850PRO2YOR323CverifiedGamma-glutamyl phosphate reductase, catalyzes the second stepin proline biosynthesis 0.041470.5095&radic&radic&radic&radic&radic&radic S000002907LCD1YDR499WverifiedEssential protein required for the DNA integrity checkpointpathways; interacts physically with Mec1p;putative homolog of S. pombe Rad26 and humanATRIP 0.041020.50799&radic&radic&radic S000000770IES6YEL044WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.041090.50799&radic&radic&radic&radic S000004641CCS1YMR038CverifiedCopper chaperone for superoxide dismutase Sod1p, involved inoxidative stress protection; Met-X-Cys-X2-Cysmotif within the N-terminal portion is involvedin insertion of copper into Sod1p underconditions of copper deprivation 0.040370.5023&radic&radic&radic&radic S000003052GUP1YGL084CverifiedPlasma membrane protein with a possible role in proton symportof glycerol; member of the MBOAT family ofputative membrane-bound O-acyltransferases 0.040840.5023&radic&radic&radic&radic S000003268CAX4YGR036CverifiedDolichyl pyrophosphate (Dol-P-P) phosphatase with a luminallyoriented active site in the ER, cleaves theanhydride linkage in Dol-P-P, required forDol-P-P-linked oligosaccharide intermediatesynthesis and protein N-glycosylation &radic0.040080.5023&radic&radic&radic&radic S000003690VPS35YJL154CverifiedEndosomal subunit of membrane-associated retromer complexrequired for retrograde transport; receptorthat recognizes retrieval signals on cargoproteins, forms subcomplex with Vps26p andVps29p that selects cargo proteins forretrieval 0.040590.5023&radic&radic&radic&radic&radic&radic S000005987YPL066WUncharacterizedHypothetical protein 0.040390.5023&radic&radic&radic S000003709RFA3YJL173CverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 0.039950.50125&radic&radic&radic&radic&radic S000005046POL1YNL102WverifiedCatalytic subunit of the DNA polymerase alpha-primase complex,required for the initiation of DNA replicationduring mitotic DNA synthesis and premeiotic DNAsynthesis 0.03990.50125&radic&radic&radic&radic&radic S000002160NHP10YDL002CverifiedProtein related to mammalian high mobility group proteins;likely component of the INO80 complex, which isan ATP-dependent chromatin-remodeling complex 0.03930.4971&radic&radic S000003288RSC1YGR056WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; containstwo essential bromodomains, a bromo-adjacenthomology (BAH) domain, and an AT hook 0.038940.49648&radic&radic&radic&radic S000003387CYS4YGR155WverifiedCystathionine beta-synthase, catalyzes the synthesis ofcystathionine from serine and homocysteine, thefirst committed step in cysteine biosynthesis 0.038790.49478&radic S000002315YDL156WUncharacterizedHypothetical protein 0.038440.4892&radic&radic&radic S000002543VPS61YDR136CdubiousDubious open reading frame, unlikely to encode a protein; notconserved in closely related Saccharomycesspecies; 4% of ORF overlaps the verified geneRGP1; deletion causes a vacuolar proteinsorting defect 0.037930.4892&radic&radic&radic&radic S000002767VID21YDR359CverifiedComponent of the NuA4 histone acetyltransferase complex 0.038370.4892&radic&radic&radic&radic&radic S000003163GCN1YGL195WverifiedPositive regulator of the Gcn2p kinase activity, forms acomplex with Gcn20p; proposed to stimulateGcn2p activation by an uncharged tRNA 0.038450.4892&radic&radic S000005929CHL1YPL008WverifiedConserved nuclear protein required to establishsister-chromatid pairing during S-phase,probable DNA helicase with similarity to humanBACH1, which associates with tumor suppressorBRCA1; associates with acetyltransferase Ctf7p 0.038560.4892&radic&radic&radic&radic S000004233YLR243WUncharacterizedPutative protein of unknown function; YLR243W is an essential gene 0.038110.4892&radic&radic&radic&radic&radic&radic&radic S000005587CKA2YOR061WverifiedAlpha' catalytic subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKB1 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.037730.48881&radic&radic&radic&radic&radic&radic S000005565CKB2YOR039WverifiedBeta' regulatory subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKA2 and CKB1, the many substratesinclude transcription factors and all RNApolymerases 0.037170.48417&radic&radic&radic&radic&radic&radic S000004793YMR181CUncharacterizedProtein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene 0.036660.48147 S000005274RPD3YNL330CverifiedHistone deacetylase; regulates transcription and silencing 0.036790.48147&radic&radic&radic&radic&radic S000003101ITC1YGL133WverifiedComponent of the ATP-dependent Isw2p-Itc1p chromatin remodelingcomplex, required for repression of a-specificgenes, repression of early meiotic genes duringmitotic growth, and repression of INO1 0.036840.48147&radic S000005083RLR1YNL139CverifiedSubunit of the THO complex, which is required for efficienttranscription elongation and involved intranscriptional elongation-associatedrecombination; required for LacZ RNA expressionfrom certain plasmids 0.036730.48147&radic S000005632VAM3YOR106WverifiedSyntaxin-related protein required for vacuolar assembly;functions with Vam7p in vacuolar proteintrafficking; member of the syntaxin family ofproteins 0.036430.47968&radic&radic&radic S000006383HDA3YPR179CverifiedSubunit of a possibly tetrameric trichostatin A-sensitive classII histone deacetylase complex that contains anHda1p homodimer and an Hda2p-Hda3p heterodimer;required for the activity of the complex; hassimilarity to Hda2p 0.036150.47723&radic&radic&radic S000002817SIZ1YDR409WverifiedSUMO ligase that promotes the attachment of sumo (Smt3p; smallubiquitin-related modifier) to proteins; bindsUbc9p and may bind septins; specificallyrequired for sumoylation of septins in vivo;localized to the septin ring 0.036150.47723&radic&radic&radic&radic&radic S000004614CLU1YMR012WverifiedeIF3 component of unknown function; deletion causes defects inmitochondrial organization but not in growth ortranslation initiation, can rescue cytokinesisand mitochondrial organization defects of theDictyostelium cluA- mutant 0.035910.47568&radic&radic&radic&radic&radic S000002157NHP6BYBR089C-AverifiedHigh-mobility group non-histone chromatin protein, functionallyredundant with Nhp6Ap; homologous to mammalianhigh mobility group proteins 1 and 2; acts torecruit transcription factor Rcs1p to certainpromoters 0.03550.47253&radic&radic S000003307PRP38YGR075CverifiedUnique component of the U4/U6.U5 tri-snRNP particle,dispensable for spliceosome assembly, butrequired for conformational changes which leadto catalytic activation of the spliceosome 0.035760.47253&radic&radic&radic&radic&radic S000004251VPS63YLR261CdubiousDubious open reading frame, unlikely to encode a protein; notconserved in closely related Saccharomycesspecies; 98% of ORF overlaps the verified geneYPT6; deletion causes a vacuolar proteinsorting defect 0.035530.47253&radic&radic&radic S000000281SLM4YBR077CverifiedComponent of the EGO complex, which is involved in theregulation of microautophagy, and of the GSEcomplex, which is required for proper sortingof amino acid permease Gap1p; gene exhibitssynthetic genetic interaction with MSS4 0.035420.47253 S000002713HNT2YDR305CverifiedDinucleoside triphosphate hydrolase; has similarity to thetumor suppressor FHIT and belongs to thehistidine triad (HIT) superfamily ofnucleotide-binding proteins &radic0.035360.47253&radic&radic&radic&radic&radic&radic&radic S000000362AMN1YBR158WverifiedProtein required for daughter cell separation, multiple mitoticcheckpoints, and chromosome stability; contains12 degenerate leucine-rich repeat motifs;expression is induced by the Mitotic ExitNetwork (MEN) 0.035310.47015&radic&radic S000002259DUN1YDL101CverifiedCell-cycle checkpoint serine-threonine kinase required for DNAdamage-induced transcription of certain targetgenes, phosphorylation of Rad55p and Sml1p, andtransient G2/M arrest after DNA damage; alsoregulates postreplicative DNA repair 0.034990.47015&radic&radic S000003905MGM101YJR144WverifiedProtein involved in mitochondrial genome maintenance; componentof the mitochondrial nucleoid, required for therepair of oxidative mtDNA damage 0.035070.47015 S000001587GFA1YKL104CverifiedGlutamine-fructose-6-phosphate amidotransferase, catalyzes theformation of glucosamine-6-P and glutamate fromfructose-6-P and glutamine in the first step ofchitin biosynthesis 0.034660.46825&radic&radic&radic&radic&radic S000005257YNL313CUncharacterizedProtein required for cell viability 0.034680.46825&radic&radic&radic&radic S000003445RTA1YGR213CverifiedProtein involved in 7-aminocholesterol resistance; has sevenpotential membrane-spanning regions 0.03450.46526&radic&radic&radic S000005662IDH2YOR136WverifiedSubunit of mitochondrial NAD(+)-dependent isocitratedehydrogenase, which catalyzes the oxidation ofisocitrate to alpha-ketoglutarate in the TCAcycle 0.034210.4644&radic&radic&radic S000000987YER185WUncharacterizedHypothetical protein 0.034250.4644 S000001085DOG2YHR043Cverified2-deoxyglucose-6-phosphate phosphatase, member of a family oflow molecular weight phosphatases, similar toDog1p, induced by oxidative and osmotic stress,confers 2-deoxyglucose resistance whenoverexpressed 0.034120.46399&radic&radic&radic&radic&radic S000000662RAD18YCR066WverifiedProtein involved in postreplication repair; bindssingle-stranded DNA and has single-stranded DNAdependent ATPase activity; forms heterodimerwith Rad6p; contains RING-finger motif &radic0.034160.46399 S000003026RAD6YGL058WverifiedUbiquitin-conjugating enzyme (E2), involved in postreplicationrepair (with Rad18p), sporulation, telomeresilencing, and ubiquitin-mediated N-end ruleprotein degradation (with Ubr1p) 0.034080.46372&radic&radic&radic&radic&radic S000001019RIM101YHL027WverifiedTranscriptional repressor involved in response to pH and incell wall construction; required for alkalinepH-stimulated haploid invasive growth andsporulation; activated by proteolyticprocessing; similar to A. nidulans PacC 0.033280.45872&radic&radic&radic&radic S000006227EAF3YPR023CverifiedEsa1p-associated factor, nonessential component of the NuA4acetyltransferase complex, homologous toDrosophila dosage compensation protein MSL3 0.033670.45872&radic S000002286VCX1YDL128WverifiedVacuolar H+/Ca2+ exchanger involved in control of cytosolicCa2+ concentration; has similarity tosodium/calcium exchangers, including the bovineNa+/Ca2+,K+ antiporter 0.03320.45819 S000004682VPS20YMR077CverifiedMyristoylated subunit of ESCRTIII, the endosomal sortingcomplex required for transport of transmembraneproteins into the multivesicular body pathwayto the lysosomal/vacuolar lumen; cytoplasmicprotein recruited to endosomal membranes 0.033020.45745 S000000205NTH2YBR001CverifiedPutative neutral trehalase, required for thermotolerance andmay mediate resistance to other cellularstresses 0.032740.45445&radic&radic S000004363ROM2YLR371WverifiedGDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutationsare synthetically lethal with mutations inrom1, which also encodes a GEP 0.032540.45226&radic&radic&radic&radic&radic&radic S000002786LSM6YDR378CverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.032610.45226&radic&radic&radic&radic S000001042YHL050CUncharacterizedPutative protein of unknown function, potential Cdc28p substrate 0.032650.45226 S000002508ARX1YDR101CverifiedShuttling pre-60S factor; involved in the biogenesis ofribosomal large subunit biogenesis; interactsdirectly with Alb1; responsible for Tif6recycling defects in absence of Rei1;associated with the ribosomal export complex 0.032180.44971&radic&radic S000005455HMI1YOL095CverifiedMitochondrial inner membrane localized ATP-dependent DNAhelicase, required for the maintenance of themitochondrial genome; not required formitochondrial transcription; has homology to E.coli helicase uvrD &radic0.032240.44971 S000005401NOP12YOL041CverifiedNucleolar protein, required for pre-25S rRNA processing;contains an RNA recognition motif (RRM) and hassimilarity to Nop13p, Nsr1p, and putativeorthologs in Drosophila and S. pombe 0.031950.44724&radic&radic&radic&radic&radic S000000283RPG1YBR079CverifiedSubunit of the core complex of translation initiation factor3(eIF3), essential for translation; part of asubcomplex (Prt1p-Rpg1p-Nip1p) that stimulatesbinding of mRNA and tRNA(i)Met to ribosomes 0.031810.44643&radic&radic S000002385GCS1YDL226CverifiedADP-ribosylation factor GTPase activating protein (ARF GAP),involved in ER-Golgi transport; sharesfunctional similarity with Glo3p 0.031820.44643&radic S000003326VAS1YGR094WverifiedMitochondrial and cytoplasmic valyl-tRNA synthetase 0.031840.44643&radic&radic&radic&radic&radic&radic&radic&radic S000004966HDA1YNL021WverifiedPutative catalytic subunit of a class II histone deacetylasecomplex that also contains Hda2p and Hda3p;Hda1p interacts with the Hda2p-Hda3p subcomplexto form an active tetramer; deletion increaseshistone H2B, H3 and H4 acetylation 0.031630.44444&radic S000003651ASF1YJL115WverifiedNucleosome assembly factor, involved in chromatin assembly anddisassembly, anti-silencing protein that causesderepression of silent loci when overexpressed 0.031570.44408&radic&radic S000005508SPT20YOL148CverifiedSubunit of the SAGA transcriptional regulatory complex,involved in maintaining the integrity of thecomplex 0.031220.43818&radic S000006050TAF14YPL129WverifiedSubunit (30 kDa) of TFIID, TFIIF, and SWI/SNF complexes,involved in RNA polymerase II transcriptioninitiation and in chromatin modification,contains a YEATS domain 0.031220.43818&radic&radic&radic S000003899IML1YJR138WverifiedProtein of unknown function, green fluorescent protein(GFP)-fusion protein localizes to the vacuolarmembrane 0.031440.43818 S000000288MIS1YBR084WverifiedMitochondrial C1-tetrahydrofolate synthase, involved ininterconversion between different oxidationstates of tetrahydrofolate (THF); providesactivities of formyl-THF synthetase,methenyl-THF cyclohydrolase, and methylene-THFdehydrogenase 0.031210.43818 S000006072PRP46YPL151CverifiedSplicing factor that is found in the Cef1p subcomplex of thespliceosome 0.030720.43358&radic&radic&radic&radic&radic&radic S000000814PRE1YER012Wverified20S proteasome beta-type subunit; localizes to the nucleusthroughout the cell cycle 0.030920.43358&radic&radic&radic&radic S000005177BNI4YNL233WverifiedTargeting subunit for Glc7p protein phosphatase, localized tothe bud neck, required for localization ofchitin synthase III to the bud neck viainteraction with the chitin synthase IIIregulatory subunit Skt5p 0.030890.43358&radic&radic&radic&radic&radic S000004434SIR3YLR442CverifiedSilencing protein that interacts with Sir2p and Sir4p, andhistone H3 and H4 tails, to establish atranscriptionally silent chromatin state;required for spreading of silenced chromatin;recruited to chromatin through interaction withRap1p 0.03030.43126 S000001065MYO1YHR023WverifiedType II myosin heavy chain, required for wild-type cytokinesisand cell separation; localizes to theactomyosin ring; binds to myosin light chainsMlc1p and Mlc2p through its IQ1 and IQ2 motifsrespectively 0.030420.43126 S000002487VPS41YDR080WverifiedVacuolar membrane protein that is a subunit of the homotypicvacuole fusion and vacuole protein sorting(HOPS) complex; essential for membrane dockingand fusion at the Golgi-to-endosome andendosome-to-vacuole stages of protein transport 0.030210.43097&radic&radic&radic&radic&radic S000004814RAD14YMR201CverifiedProtein that recognizes and binds damaged DNA during nucleotideexcision repair; subunit of Nucleotide ExcisionRepair Factor 1 (NEF1); contains zinc fingermotif; homolog of human XPA protein 0.029970.42704&radic&radic&radic&radic&radic&radic&radic S000001297CKA1YIL035CverifiedAlpha catalytic subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA2, CKB1 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.029970.42704&radic&radic&radic&radic&radic&radic&radic S000000154SHP1YBL058WverifiedUBX (ubiquitin regulatory X) domain-containing protein thatregulates Glc7p phosphatase activity andinteracts with Cdc48p; interacts withubiquitylated proteins in vivo and is requiredfor degradation of a ubiquitylated modelsubstrate 0.029840.42636&radic&radic&radic&radic&radic&radic S000003323PRP31YGR091WverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.029810.42636&radic&radic&radic S000004730PKR1YMR123WverifiedV-ATPase assembly factor, functions with other V-ATPaseassembly factors in the ER to efficientlyassemble the V-ATPase membrane sector(V0); overproduction confersresistance to Pichia farinosa killer toxin 0.029790.42578 S000004733DLT1YMR126CuncharacterizedProtein of unknown function, deletion causes sensitivity tothermal stress 0.029660.42525&radic S000002987CKB1YGL019WverifiedBeta regulatory subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKA2 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.029320.42256&radic&radic&radic&radic&radic&radic&radic S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling 0.029440.42256&radic&radic&radic&radic&radic&radic&radic&radic&radic&radic S000003466YHB1YGR234WverifiedNitric oxide oxidoreductase, flavohemoglobin involved in nitricoxide detoxification; plays a role in theoxidative and nitrosative stress responses 0.029310.42256&radic&radic&radic&radic S000004847RNH1YMR234WverifiedRibonuclease H1, removes RNA primers during Okazaki fragmentsynthesis; degrades RNA attached to the 5'-endof a DNA strand 0.029210.41984&radic&radic&radic&radic&radic&radic S000001086DOG1YHR044Cverified2-deoxyglucose-6-phosphate phosphatase, similar to Dog2p,member of a family of low molecular weightphosphatases; confers 2-deoxyglucose resistancewhen overexpressed, in vivo substrate has notyet been identified 0.029190.41984&radic&radic&radic&radic&radic S000001584HSL1YKL101WverifiedNim1p-related protein kinase that regulates the morphogenesisand septin checkpoints; associates with theassembled septin filament; required along withHsl7p for bud neck recruitment,phosphorylation, and degradation of Swe1p 0.028770.41274&radic&radic S000004388VPS33YLR396CverifiedATP-binding protein that is a subunit of the homotypic vacuolefusion and vacuole protein sorting (HOPS)complex; essential for membrane docking andfusion at both the Golgi-to-endosome andendosome-to-vacuole stages of protein transport 0.028850.41274&radic&radic&radic&radic&radic S000002772CDC40YDR364CverifiedPre-mRNA splicing factor, important for catalytic step II ofpre-mRNA splicing and plays a role in cellcycle progression; required for DNA synthesisduring mitosis and meiosis; has WD repeats 0.028760.41274&radic&radic&radic&radic&radic&radic S000000514STP22YCL008CverifiedComponent of the ESCRT-I complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; homologous to the mouse and humanTsg101 tumor susceptibility gene; mutantsexhibit a Class E Vps phenotype 0.028660.41274&radic&radic&radic&radic&radic&radic S000005233PCL1YNL289WverifiedPho85 cyclin of the Pcl1,2-like subfamily, involved in entryinto the mitotic cell cycle and regulation ofmorphogenesis, localizes to sites of polarizedcell growth 0.0290.41274&radic&radic&radic&radic S000004697NPL6YMR091CverifiedComponent of the RSC chromatin remodeling complex; interactswith Rsc3p, Rsc30p, Ldb7p, and Htl1p to form amodule important for a broad range of RSCfunctions; involved in nuclear protein importand maintenance of proper telomere length 0.028810.41274&radic&radic S000004467ERG6YML008CverifiedDelta(24)-sterol C-methyltransferase, converts zymosterol tofecosterol in the ergosterol biosyntheticpathway by methylating position C-24; localizedto both lipid particles and mitochondrial outermembrane 0.028610.41274 S000004975HHF2YNL030WverifiedOne of two identical histone H4 proteins (see also HHF1); corehistone required for chromatin assembly andchromosome function; contributes to telomericsilencing; N-terminal domain involved inmaintaining genomic integrity 0.028960.41274&radic S000006339CTF4YPR135WverifiedChromatin-associated protein, required for sister chromatidcohesion; interacts with DNA polymerase alpha(Pol1p) and may link DNA synthesis to sisterchromatid cohesion 0.028970.41274&radic&radic&radic&radic&radic&radic&radic S000000003EFB1YAL003WverifiedTranslation elongation factor 1 beta; stimulates nucleotideexchange to regenerate EF-1 alpha-GTP for thenext elongation cycle; part of the EF-1complex, which facilitates binding ofaminoacyl-tRNA to the ribosomal A site 0.028340.41114&radic&radic&radic&radic S000004279MEC3YLR288CverifiedDNA damage and meiotic pachytene checkpoint protein; subunit ofa heterotrimeric complex (Rad17p-Mec3p-Ddc1p)that forms a sliding clamp, loaded onto partialduplex DNA by a clamp loader complex; homologof human and S. pombe Hus1 0.028050.40701&radic&radic&radic&radic&radic S000003507RTT102YGR275WverifiedComponent of both the SWI/SNF and RSC chromatin remodelingcomplexes, suggested role in chromosomemaintenance; possible weak regulator of Ty1transposition 0.028090.40701&radic&radic&radic&radic&radic&radic S000003959PRP19YLL036CverifiedSplicing factor associated with the spliceosome; contains aU-box, a motif found in a class of ubiquitinligases 0.028190.40701&radic&radic&radic&radic S000004841MTF1YMR228WverifiedMitochondrial RNA polymerase specificity factor with structuralsimilarity to S-adenosylmethionine-dependentmethyltransferases and functional similarity tobacterial sigma-factors, interacts withmitochondrial core polymerase Rpo41p 0.027720.406&radic&radic&radic&radic&radic S000001207DNA2YHR164CverifiedEssential tripartite DNA replication factor withsingle-stranded DNA-dependent ATPase,ATP-dependent nuclease, and helicaseactivities; required for Okazaki fragmentprocessing; involved in DNA repair pathways;potential Cdc28p substrate &radic0.02780.406&radic&radic&radic&radic&radic&radic&radic S000004023RSC58YLR033WverifiedRemodels the structure of chromatin complex 58KDa subunit;Chromatin Remodeling Complex subunit 0.027340.40139&radic S000003783LSM8YJR022WverifiedLsm (Like Sm) protein; forms heteroheptameric complex (withLsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p)that is part of spliceosomal U6 snRNP and isalso implicated in processing of pre-tRNA,pre-snoRNA, and pre-rRNA 0.027320.40139&radic&radic&radic&radic S000002625RAD9YDR217CverifiedDNA damage-dependent checkpoint protein, required forcell-cycle arrest in G1/S, intra-S, and G2/M;transmits checkpoint signal by activatingRad53p and Chk1p; hyperphosphorylated by Mec1pand Tel1p; potential Cdc28p substrate 0.027230.4001&radic&radic&radic&radic&radic&radic S000005589RPL3YOR063WverifiedProtein component of the large (60S) ribosomal subunit, hassimilarity to E. coli L3 and rat L3 ribosomalproteins; involved in the replication andmaintenance of killer double stranded RNA virus 0.027220.4001&radic&radic&radic&radic S000003517ZUO1YGR285CverifiedCytosolic ribosome-associated chaperone that acts, togetherwith Ssz1p and the Ssb proteins, as a chaperonefor nascent polypeptide chains; contains a DnaJdomain and functions as a J-protein partner forSsb1p and Ssb2p 0.027010.39865&radic&radic&radic&radic S000005895RAD17YOR368WverifiedCheckpoint protein, involved in the activation of the DNAdamage and meiotic pachytene checkpoints; withMec3p and Ddc1p, forms a clamp that is loadedonto partial duplex DNA; homolog of human andS. pombe Rad1 and U. maydis Rec1 proteins 0.026820.39649&radic&radic&radic&radic S000006314RPC40YPR110CverifiedRNA polymerase subunit, common to RNA polymerase I and III 0.026710.39448&radic&radic&radic&radic&radic S000003193VRG4YGL225WverifiedGolgi GDP-mannose transporter; regulates Golgi function andglycosylation in Golgi 0.026620.39448&radic&radic&radic&radic&radic S000001868STE2YFL026WverifiedReceptor for alpha-factor pheromone; seven transmembrane-domainGPCR that interacts with both pheromone and aheterotrimeric G protein to initiate thesignaling response that leads to mating betweenhaploid a and alpha cells 0.026770.39448&radic&radic&radic&radic&radic S000002476DOA4YDR069CverifiedUbiquitin hydrolase, required for recycling ubiquitin fromproteasome-bound ubiquitinated intermediates,acts at the late endosome/prevacuolarcompartment to recover ubiquitin fromubiquitinated membrane proteins en route to thevacuole 0.026740.39448&radic&radic&radic&radic&radic&radic S000003813RAD7YJR052WverifiedProtein that recognizes and binds damaged DNA in anATP-dependent manner (with Rad16p) duringnucleotide excision repair; subunit ofNucleotide Excision Repair Factor 4 (NEF4) &radic0.02660.39114&radic&radic S000003306SMD1YGR074WverifiedCore Sm protein Sm D1; part of heteroheptameric complex (withSmb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D1 0.026420.39114&radic&radic&radic&radic&radic&radic S000003835MOG1YJR074WverifiedConserved nuclear protein that interacts with GTP-Gsp1p, whichis a Ran homolog of the Ras GTPase family, andstimulates nucleotide release, involved innuclear protein import, nucleotide release isinhibited by Yrb1p 0.026530.39114&radic S000001124KSP1YHR082CverifiedNonessential putative serine/threonine protein kinase ofunknown cellular role; overproduction causesallele-specific suppression of the prp20-10mutation 0.026220.38943&radic&radic&radic&radic&radic S000002499UBC13YDR092WverifiedUbiquitin-conjugating enzyme involved in the error-free DNApostreplication repair pathway; interacts withMms2p to assemble ubiquitin chains at the UbLys-63 residue; DNA damage triggersredistribution from the cytoplasm to thenucleus 0.026290.38943&radic S000005226POP3YNL282WverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends 0.025970.386&radic&radic&radic&radic S000005553STI1YOR027WverifiedHsp90 cochaperone, interacts with the Ssa group of thecytosolic Hsp70 chaperones; activates theATPase activity of Ssa1p; homolog of mammalianHop protein 0.026060.386&radic&radic&radic&radic&radic&radic S000003712SWI3YJL176CverifiedSubunit of the SWI/SNF chromatin remodeling complex, whichregulates transcription by remodelingchromosomes; required for transcription of manygenes, including ADH1, ADH2, GAL1, HO, INO1 andSUC2 0.025940.386&radic&radic&radic&radic S000006236SRO7YPR032WverifiedPutative effector of Rab GTPase Sec4p, forms a complex withSec4p and t-SNARE Sec9p; involved in exocytosisand docking and fusion of post-Golgi vesicleswith plasma membrane; homolog of Sro77p andDrosophila lgl tumor suppressor 0.025940.386&radic&radic S000001867GYP8YFL027CverifiedGTPase-activating protein for yeast Rab family members; Ypt1pis the preferred in vitro substrate but alsoacts on Sec4p, Ypt31p and Ypt32p; involved inthe regulation of ER to Golgi vesicle transport 0.025820.3851&radic&radic&radic S000004560RAD10YML095CverifiedSingle-stranded DNA endonuclease (with Rad1p), cleavessingle-stranded DNA during nucleotide excisionrepair and double-strand break repair; subunitof Nucleotide Excision Repair Factor 1 (NEF1);homolog of human ERCC1 protein 0.025340.37932&radic&radic&radic S000003490RAD2YGR258CverifiedSingle-stranded DNA endonuclease, cleaves single-stranded DNAduring nucleotide excision repair to excisedamaged DNA; subunit of Nucleotide ExcisionRepair Factor 3 (NEF3); homolog of human XPGprotein 0.02540.37932&radic&radic S000004837MRE11YMR224CverifiedSubunit of a complex with Rad50p and Xrs2p (RMX complex) thatfunctions in repair of DNA double-strand breaksand in telomere stability, exhibits nucleaseactivity that appears to be required for RMXfunction; widely conserved 0.025360.37932&radic&radic&radic&radic&radic&radic&radic S000003207CSE1YGL238WverifiedNuclear envelope protein that mediates the nuclear export ofimportin alpha (Srp1p), homolog of metazoan CASprotein, required for accurate chromosomesegregation 0.025520.37932&radic&radic&radic&radic&radic&radic&radic S000000948LSM5YER146WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.025320.37932 S000005372HTZ1YOL012CverifiedHistone variant H2AZ, exchanged for histone H2A in nucleosomesby the SWR1 complex; involved intranscriptional regulation through preventionof the spread of silent heterochromatin 0.02560.37932&radic&radic&radic&radic&radic S000004605YMR003WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria; YMR003W is not an essential gene 0.025510.37932&radic&radic S000004650NUP116YMR047CverifiedSubunit of the nuclear pore complex (NPC) that is localized toboth sides of the pore; contains a repetitiveGLFG motif that interacts with mRNA exportfactor Mex67p and with karyopherin Kap95p;homologous to Nup100p 0.025170.37864&radic&radic S000000189ROX3YBL093CverifiedRNA polymerase II holoenzyme component 0.025190.37864&radic&radic&radic&radic S000001288IRR1YIL026CverifiedSubunit of the cohesin complex, which is required for sisterchromatid cohesion during mitosis and meiosisand interacts with centromeres and chromosomearms, essential for viability 0.025110.37813&radic&radic&radic&radic&radic&radic S000006323CLB2YPR119WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the transition from G2 to Mphase; accumulates during G2 and M, thentargeted via a destruction box motif forubiquitin-mediated degradation by theproteasome 0.02480.37428&radic&radic&radic S000004844PEP5YMR231WverifiedPeripheral vacuolar membrane protein required for proteintrafficking and vacuole biogenesis; formscomplex with Pep3p that promotes vesiculardocking/fusion reactions in conjunction withSNARE proteins, also interacts with Pep7p 0.024880.37428&radic&radic&radic S000003038RPB9YGL070CverifiedRNA polymerase II subunit B12.6; contacts DNA; mutations affecttranscription start site; involved in telomeremaintenance 0.024660.371&radic&radic&radic&radic&radic S000000673PAT1YCR077CverifiedTopoisomerase II-associated deadenylation-dependentmRNA-decapping factor; also required forfaithful chromosome transmission, maintenanceof rDNA locus stability, and protection of mRNA3'-UTRs from trimming; functionally linked toPab1p 0.024530.371&radic S000002837TIF35YDR429CverifiedSubunit of the core complex of translation initiation factor3(eIF3), which is essential for translation 0.024520.371&radic&radic&radic&radic&radic S000000865THO1YER063WverifiedProtein of unknown function; overproduction suppresses thetranscriptional defect caused by an hpr1mutation 0.024660.371&radic S000001900RPN11YFR004WverifiedMetalloprotease subunit of the 19S regulatory particle of the26S proteasome lid; couples thedeubiquitination and degradation of proteasomesubstrates 0.024320.36796&radic&radic&radic S000000949SCC4YER147CverifiedSubunit of cohesin loading factor (Scc2p-Scc4p), a complexrequired for the loading of cohesin complexesonto chromosomes; involved in establishingsister chromatid cohesion during double-strandbreak repair via phosphorylated histone H2AX 0.024270.36697&radic&radic S000004444SST2YLR452CverifiedGTPase-activating protein for Gpa1p, regulates desensitizationto alpha factor pheromone; also required toprevent receptor-independent signaling of themating pathway; member of the RGS (regulator ofG-protein signaling) family 0.02420.36697&radic&radic S000003452MRPL9YGR220CverifiedMitochondrial ribosomal protein of the large subunit 0.024140.36487&radic&radic&radic S000000493SNF5YBR289WverifiedSubunit of the SWI/SNF chromatin remodeling complex involved intranscriptional regulation; functionsinterdependently in transcriptional activationwith Snf2p and Snf6p 0.024090.36487&radic S000002711RSC3YDR303CverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; essential gene required forregulation of ribosomal protein genes and thecell wall/stress response; highly similar toRsc30p 0.02410.36487&radic&radic S000002444KRS1YDR037WverifiedLysyl-tRNA synthetase; also identified as a negative regulatorof general control of amino acid biosynthesis 0.024050.36487&radic S000005051YAF9YNL107WverifiedSubunit of both the NuA4 histone H4 acetyltransferase complexand the SWR1 complex, may function toantagonize silencing near telomeres; interactsdirectly with Swc4p, has homology to humanleukemogenic protein AF9, contains a YEATSdomain 0.024120.36487&radic&radic S000005888PRT1YOR361CverifiedSubunit of the core complex of translation initiation factor3(eIF3), essential for translation; part of asubcomplex (Prt1p-Rpg1p-Nip1p) that stimulatesbinding of mRNA and tRNA(i)Met to ribosomes 0.023810.36218&radic&radic&radic&radic S000000122LSM2YBL026WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.023880.36218&radic&radic&radic&radic&radic S000005670ELG1YOR144CverifiedProtein required for S phase progression and telomerehomeostasis, forms an alternative replicationfactor C complex important for DNA replicationand genome integrity; involved in homologousrecombination-mediated DNA repair 0.023840.36218&radic&radic&radic&radic&radic&radic&radic S000002915GIN4YDR507CverifiedProtein kinase involved in bud growth and assembly of theseptin ring, proposed to have kinase-dependentand kinase-independent activities; undergoesautophosphorylation; similar to Kcc4p and Hsl1p 0.023850.36218&radic S000003065SRM1YGL097WverifiedNucleotide exchange factor for Gsp1p, localizes to the nucleus,required for nucleocytoplasmic trafficking ofmacromolecules; potentially phosphorylated byCdc28p 0.023760.35839&radic&radic S000002764SPC110YDR356WverifiedInner plaque spindle pole body (SPB) component, ortholog ofhuman kendrin; involved in connecting nuclearmicrotubules to SPB; interacts withTub4p-complex and calmodulin; phosphorylated byMps1p in cell cycle-dependent manner 0.023740.35839&radic&radic&radic&radic S000002533SWF1YDR126WverifiedPalmitoyltransferase that acts on the SNAREs Snc1p, Syn8p,Tlg1p and likely on all SNAREs; member of afamily of putative palmitoyltransferasescontaining an Asp-His-His-Cys-cysteine rich(DHHC-CRD) domain; may have a role in vacuolefusion 0.023750.35839&radic&radic&radic&radic&radic&radic&radic S000001876LPD1YFL018CverifiedDihydrolipoamide dehydrogenase, the lipoamide dehydrogenasecomponent (E3) of the pyruvate dehydrogenaseand 2-oxoglutarate dehydrogenase multi-enzymecomplexes 0.023640.35839&radic S000000052GPB2YAL056WverifiedProposed beta subunit of the heterotrimeric G protein;interacts with the receptor Grp1p, affectssignaling by altering the level ofphosphorylation of PKS substrates; regulatespseudohyphal growth through cAMP levels;homolog of Gpb1p 0.023690.35839&radic&radic&radic&radic&radic&radic&radic S000005008YDJ1YNL064CverifiedProtein chaperone involved in regulation of the HSP90 and HSP70functions; involved in protein translocationacross membranes; member of the DnaJ family 0.023410.35667&radic&radic&radic S000003217PDE1YGL248WverifiedLow-affinity cyclic AMP phosphodiesterase, controls glucose andintracellular acidification-induced cAMPsignaling, target of the cAMP-protein kinase A(PKA) pathway; glucose induces transcriptionand inhibits translation 0.023450.35667&radic&radic&radic&radic&radic&radic S000005534SLG1YOR008CverifiedSensor-transducer of the stress-activated PKC1-MPK1 kinasepathway involved in maintenance of cell wallintegrity; involved in organization of theactin cytoskeleton; secretory pathway Wsc1p isrequired for the arrest of secretion response 0.02340.35667&radic S000005205ORC5YNL261WverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing &radic0.023390.35588&radic&radic&radic&radic S000003364PHB1YGR132CverifiedSubunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDaring-shaped inner mitochondrial membranechaperone that stabilizes newly synthesizedproteins; determinant of replicative life span;involved in mitochondrial segregation 0.023170.35337&radic&radic&radic S000003793CPR7YJR032WverifiedPeptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzesthe cis-trans isomerization of peptide bondsN-terminal to proline residues; binds to Hsp82pand contributes to chaperone activity 0.023080.35246&radic S000001915FAB1YFR019Wverified1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membranekinase that generates phosphatidylinositol(3,5)P2, which is involved in vacuolar sortingand homeostasis 0.022980.35172 S000000259PRP6YBR055CverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.022850.34382&radic&radic S000002520PDS1YDR113CverifiedSecurin that inhibits anaphase by binding separin Esp1p, alsoblocks cyclin destruction and mitotic exit,essential for cell cycle arrest in mitosis inthe presence of DNA damage or aberrant mitoticspindles; also present in meiotic nuclei 0.022610.34382&radic&radic&radic S000006260TFB4YPR056WverifiedSubunit of TFIIH complex, involved in transcription initiation,similar to 34 kDa subunit of human TFIIH;interacts with Ssl1p 0.022540.34382&radic&radic S000003440SER2YGR208WverifiedPhosphoserine phosphatase of the phosphoglycerate pathway,involved in serine and glycine biosynthesis,expression is regulated by the availablenitrogen source 0.022480.34382&radic&radic&radic&radic&radic&radic&radic S000000364CDC28YBR160WverifiedCatalytic subunit of the main cell cycle cyclin-dependentkinase (CDK); alternately associates with G1cyclins (CLNs) and G2/M cyclins (CLBs) whichdirect the CDK to specific substrates 0.022740.34382&radic&radic&radic S000001447PRI1YIR008CverifiedSubunit of DNA primase, which is required for DNA synthesis anddouble-strand break repair 0.022660.34382 S000002255RPN6YDL097CverifiedEssential, non-ATPase regulatory subunit of the 26S proteasomelid required for the assembly and activity ofthe 26S proteasome; the human homolog (S9protein) partially rescues Rpn6p depletion 0.022760.34382&radic&radic S000000950SPT15YER148WverifiedTATA-binding protein, general transcription factor thatinteracts with other factors to form thepreinitiation complex at promoters, essentialfor viability 0.022630.34382&radic S000000831SMB1YER029CverifiedCore Sm protein Sm B; part of heteroheptameric complex (withSmd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm B and Sm B' 0.022760.34382&radic&radic S000003136HUR1YGL168WuncharacterizedProtein required for hydroxyurea resistance; has possible rolesin DNA replication and maintenance of propertelomere length 0.022840.34382&radic&radic S000000298PBY1YBR094WuncharacterizedP-body associated protein 0.022580.34382&radic S000002216USO1YDL058WverifiedEssential protein involved in intracellular protein transport,coiled-coil protein necessary for transportfrom ER to Golgi; required for assembly of theER-to-Golgi SNARE complex 0.022450.34287 S000002718SUM1YDR310CverifiedTranscriptional repressor required for mitotic repression ofmiddle sporulation-specific genes; involved intelomere maintenance, regulated by thepachytene checkpoint 0.022420.34287&radic&radic&radic&radic S000003772YJR011CUncharacterizedHypothetical protein 0.022260.34039&radic S000002330GLT1YDL171CverifiedNAD(+)-dependent glutamate synthase (GOGAT), synthesizesglutamate from glutamine andalpha-ketoglutarate; with Gln1p, forms thesecondary pathway for glutamate biosynthesisfrom ammonia; expression regulated by nitrogensource 0.022160.33986 S000005682NFI1YOR156CverifiedSUMO ligase, catalyzes the covalent attachment of SUMO (Smt3p)to proteins; involved in maintenance of propertelomere length 0.022150.33986&radic&radic&radic&radic&radic&radic&radic S000003175SPT16YGL207WverifiedSubunit of the heterodimeric FACT complex (Spt16p-Pob3p),facilitates RNA Polymerase II transcriptionelongation through nucleosomes by destabilizingand then reassembling nucleosome structure 0.02210.33795&radic&radic&radic S000002304COP1YDL145CverifiedAlpha subunit of COPI vesicle coatomer complex, which surroundstransport vesicles in the early secretorypathway 0.022140.33795 S000002733YCG1YDR325WverifiedNon-SMC subunit of the condensin complex(Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required forestablishment and maintenance of chromosomecondensation, chromosome segregation and forchromatin binding of the condensin complex 0.02210.33795&radic&radic S000003335NOP7YGR103WverifiedNucleolar protein involved in rRNA processing and 60S ribosomalsubunit biogenesis; constituent of severaldifferent pre-ribosomal particles; required forexit from G0 and the initiation ofcell proliferation 0.021870.33492&radic&radic&radic&radic&radic S000002217RAD59YDL059CverifiedProtein involved in the repair of double-strand breaks in DNAduring vegetative growth via recombination andsingle-strand annealing; anneals complementarysingle-stranded DNA; homologous to Rad52p 0.0220.33492&radic&radic S000003983GTT2YLL060CverifiedGlutathione S-transferase capable of homodimerization;functional overlap with Gtt2p, Grx1p, and Grx2p 0.021930.33492&radic&radic&radic&radic&radic S000005835SNU66YOR308CverifiedComponent of the U4/U6.U5 snRNP complex involved in pre-mRNAsplicing via spliceosome; has homology to humanSART-1 and to an S. pombe protein; snu66 nullmutation confers cold-sensitivity but is notlethal at normal growth temperatures 0.0220.33492&radic&radic&radic&radic&radic S000002918SMT3YDR510WverifiedUbiquitin-like protein of the SUMO family, conjugated to lysineresidues of target proteins; regulateschromatid cohesion, chromosome segregation,APC-mediated proteolysis, DNA replication andseptin ring dynamics 0.021810.33419&radic&radic S000003180VAM7YGL212WverifiedComponent of the vacuole SNARE complex involved in vacuolarmorphogenesis; SNAP-25 homolog; functions witha syntaxin homolog Vam3p in vacuolar proteintrafficking 0.021660.33141&radic&radic&radic&radic&radic&radic&radic S000004525OGG1YML060WverifiedMitochondrial glycosylase/lyase that specifically excises7,8-dihydro-8-oxoguanine residues locatedopposite cytosine or thymine residues in DNA,repairs oxidative damage to mitochondrial DNA 0.021690.33141&radic&radic S000001197RTT107YHR154WverifiedProtein implicated in Mms22-dependent DNA repair during Sphase, DNA damage induces phosphorylation byMec1p at one or more SQ/TQ motifs; interactswith Mms22p and Slx4p; has four BRCT domains;has a role in regulation of Ty1 transposition 0.021680.33141&radic&radic&radic&radic S000000359CNS1YBR155WverifiedTPR-containing co-chaperone; binds both Hsp82p (Hsp90) andSsa1p (Hsp70) and stimulates the ATPaseactivity of SSA1, ts mutants reduce Hsp82pfunction while over expression suppresses thephenotypes of an HSP82 ts allele and a cpr7deletion 0.021640.33141&radic&radic S000002535YDR128WUncharacterizedHypothetical protein 0.021560.32928&radic&radic&radic S000005787RPN8YOR261CverifiedEssential, non-ATPase regulatory subunit of the 26S proteasome;has similarity to the human p40 proteasomalsubunit and to another S. cerevisiae regulatorysubunit, Rpn11p 0.021480.32928&radic&radic&radic S000007235SEM1YDR363W-AverifiedComponent of the lid subcomplex of the regulatory subunit ofthe 26S proteasome; ortholog of human DSS1 0.021430.32928&radic S000006434LSM3YLR438C-AverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.021440.32928&radic&radic S000005227WSC2YNL283CverifiedPartially redundant sensor-transducer of the stress-activatedPKC1-MPK1 signaling pathway involved inmaintenance of cell wall integrity and recoveryfrom heat shock; secretory pathway Wsc2p isrequired for the arrest of secretion response 0.021570.32928&radic&radic&radic S000005559EXO1YOR033Cverified5'-3' exonuclease and flap-endonuclease involved inrecombination, double-strand break repair andDNA mismatch repair; member of the Rad2pnuclease family, with conserved N and Inuclease domains 0.02140.32876&radic&radic&radic&radic&radic S000006386SMX3YPR182WverifiedCore Sm protein Sm F; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm F 0.021250.32692&radic&radic&radic&radic S000002575CDC37YDR168WverifiedEssential Hsp90p co-chaperone; necessary for passage throughthe START phase of the cell cycle 0.02130.32692&radic&radic&radic&radic S000003272KSS1YGR040WverifiedMitogen-activated protein kinase (MAPK) involved in signaltransduction pathways that control filamentousgrowth and pheromone response 0.021320.32692&radic&radic&radic&radic S000006220TIF6YPR016CverifiedConstituent of 66S pre-ribosomal particles, has similarity tohuman translation initiation factor 6 (eIF6);may be involved in the biogenesis and orstability of 60S ribosomal subunits 0.021320.32692&radic S000002251PMT5YDL093WverifiedProtein O-mannosyltransferase, transfers mannose residues fromdolichyl phosphate-D-mannose to proteinserine/threonine residues; acts in a complexwith Pmt3p, can instead interact with Pmt2p insome conditions; target for new antifungals 0.021150.32581&radic&radic S000002881PRP3YDR473CverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.021110.32412&radic&radic S000004365VID22YLR373CverifiedGlycosylated integral membrane protein localized to the plasmamembrane; plays a role infructose-1,6-bisphosphatase (FBPase)degradation; involved in FBPase transport fromthe cytosol to Vid (vacuole import anddegradation) vesicles 0.021150.32412&radic&radic&radic&radic&radic S000005738STE4YOR212WverifiedG protein beta subunit, forms a dimer with Ste18p to activatethe mating signaling pathway, forms aheterotrimer with Gpa1p and Ste18p to dampensignaling; may recruit Rho1p to the polarizedgrowth site during mating; contains WD40repeats 0.021080.32412&radic&radic&radic&radic&radic&radic&radic S000004034PDC1YLR044CverifiedMajor of three pyruvate decarboxylase isozymes, key enzyme inalcoholic fermentation, decarboxylates pyruvateto acetaldehyde; subject to glucose-, ethanol-,and autoregulation; involved in amino acidcatabolism 0.020980.32328&radic&radic&radic&radic&radic S000001176WSS1YHR134WverifiedSumoylated protein of unknown function, identified based ongenetic interactions with SMT3; UV-sensitivemutant phenotype and genetic interactionssuggest a role in the DNA damage response,processing stalled or collapsed replicationforks 0.020970.32237&radic&radic&radic&radic S000000063NUP60YAR002WverifiedSubunit of the nuclear pore complex (NPC), functions to anchorNup2p to the NPC in a process controlled by thenucleoplasmic concentration of Gsp1p-GTP;potential Cdc28p substrate; involved intelomere maintenance 0.020890.32116&radic&radic&radic&radic S000004015SNF7YLR025WverifiedOne of four subunits of the endosomal sorting complex requiredfor transport III (ESCRT-III); involved in thesorting of transmembrane proteins into themultivesicular body (MVB) pathway; recruitedfrom the cytoplasm to endosomal membranes 0.020890.32116&radic&radic&radic S000005509DCP1YOL149WverifiedSubunit of the Dcp1p-Dcp2p decapping enzyme complex, whichremoves the 5' cap structure from mRNAs priorto their degradation; enhances the activity ofcatalytic subunit Dcp2p; regulated by DEAD boxprotein Dhh1p &radic0.020860.32116&radic&radic S000001881IES1YFL013CverifiedSubunit of the INO80 chromatin remodeling complex 0.02090.32116&radic&radic S000003992NOC3YLR002CverifiedProtein that forms a nuclear complex with Noc2p that binds to66S ribosomal precursors to mediate theirintranuclear transport; also binds to chromatinto promote the association of DNA replicationfactors and replication initiation 0.020920.32116&radic&radic&radic&radic S000000146SEC17YBL050WverifiedPeripheral membrane protein required for vesicular transportbetween ER and Golgi and for the 'priming' stepin homotypic vacuole fusion, part of thecis-SNARE complex; has similarity to alpha-SNAP 0.020880.32116&radic&radic&radic S000000914LSM4YER112WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.02090.32116&radic&radic S000003737ECM25YJL201WverifiedNon-essential protein of unknown function; promoter contains aconsensus binding sequence for factor Abf1p 0.020830.32056&radic