Yfunc lets you browse current and predicted gene functions in yeast

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Prediction of GO:0016741 "transferase activity, transferring one-carbon groups"

GO branch: MF
Number of currently annotated genes: 84

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest Huh:nucleusLum:GliotoxinHuh:cytoplasmHarbison:IME1_YPDLum:IbuprofenLum:StaurosporineHarbison:SFL1_YPDHarbison:IME1_H2O2HiLum:Valproic AcidLum:Naproxen S000001161SET1YHR119WverifiedHistone methyltransferase, subunit of the COMPASS (Set1C)complex which methylates histone H3 on lysine4; required in transcriptional silencing neartelomeres and at the silent mating type loci;contains a SET domain &radic0.566440.95823&radic&radic&radic S000000064SWD1YAR003WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres; WD40beta propeller superfamily member withsimilarity to mammalian Rbbp7 &radic0.423010.93469&radic&radic&radic&radic&radic S000004005BRE2YLR015WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres;involved in telomere maintenance; similar totrithorax-group protein ASH2L &radic0.406490.93469&radic&radic&radic&radic&radic&radic S000000379SWD3YBR175WverifiedEssential subunit of the COMPASS (Set1C) complex, whichmethylates histone H3 on lysine 4 and isrequired in transcriptional silencing neartelomeres; WD40 beta propeller superfamilymember and ortholog of mammalian WDR5 &radic0.39740.93469&radic&radic&radic&radic&radic S000004467ERG6YML008CverifiedDelta(24)-sterol C-methyltransferase, converts zymosterol tofecosterol in the ergosterol biosyntheticpathway by methylating position C-24; localizedto both lipid particles and mitochondrial outermembrane &radic0.409290.93469&radic&radic&radic S000002877SDC1YDR469WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres; hassimilarity to C. elegans Dpy-30 &radic0.391340.93376&radic&radic&radic S000004727ADE17YMR120CverifiedEnzyme of 'de novo' purine biosynthesis containing both5-aminoimidazole-4-carboxamide ribonucleotidetransformylase and inosine monophosphatecyclohydrolase activities, isozyme of Ade16p;ade16 ade17 mutants require adenine andhistidine &radic0.363190.92767&radic S000002547MTQ2YDR140WuncharacterizedS-adenosylmethionine-dependent methyltransferase of the sevenbeta-strand family; methylates release factoreRF1 (Sup45p) in vitro; is not an essentialgene; similar to E.coli PrmC &radic0.361890.92589&radic&radic&radic&radic&radic S000004018ADE16YLR028CverifiedEnzyme of 'de novo' purine biosynthesis containing both5-aminoimidazole-4-carboxamide ribonucleotidetransformylase and inosine monophosphatecyclohydrolase activities, isozyme of Ade17p;ade16 ade17 mutants require adenine andhistidine &radic0.356460.92332&radic&radic S000005484TRM11YOL124CverifiedCatalytic subunit of an adoMet-dependent tRNA methyltransferasecomplex (Trm11p-Trm112p), required for themethylation of the guanosine nucleotide atposition 10 (m2G10) in tRNAs; contains a THUMPdomain and a methyltransferase domain &radic0.336890.916&radic S000000559SPB1YCL054WverifiedAdoMet-dependent methyltransferase involved in rRNA processingand 60S ribosomal subunit maturation;methylates G2922 in the tRNA docking site ofthe large subunit rRNA and in the absence ofsnR52, U2921; suppressor of PAB1 mutants &radic0.320870.90476&radic&radic&radic&radic S000006059SPP1YPL138CverifiedSubunit of COMPASS (Set1C), a complex which methylates histoneH3 on lysine 4 and is required in telomerictranscriptional silencing; PHD finger domainprotein similar to human CGBP, an unmethylatedCpG binding protein &radic0.295220.8876&radic&radic&radic&radic S000004476TRM9YML014WverifiedtRNA methyltransferase, catalyzes the esterification ofmodified uridine nucleotides in tRNAs, creating5-methylcarbonylmethyluridine in tRNA(Arg3) and5-methylcarbonylmethyl-2-thiouridine intRNA(Glu); may have a role in stress response &radic0.281970.88523&radic&radic&radic S000002476DOA4YDR069CverifiedUbiquitin hydrolase, required for recycling ubiquitin fromproteasome-bound ubiquitinated intermediates,acts at the late endosome/prevacuolarcompartment to recover ubiquitin fromubiquitinated membrane proteins en route to thevacuole 0.273810.88302&radic&radic&radic S000001326YIL064WUncharacterizedPutative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family &radic0.263130.87907&radic&radic&radic&radic S000001252CRG1YHR209WuncharacterizedPutative S-adenosylmethionine-dependent methyltransferase;mediates cantharidin resistance &radic0.250940.87272&radic&radic&radic&radic S000000977TMT1YER175CverifiedTrans-aconitate methyltransferase, cytosolic enzyme thatcatalyzes the methyl esterification of3-isopropylmalate, an intermediate of theleucine biosynthetic pathway, andtrans-aconitate, which inhibits the citric acidcycle &radic0.241290.865&radic&radic S000002724OMS1YDR316WverifiedProtein integral to the mitochondrial membrane; has a conservedmethyltransferase motif; multicopy suppressorof respiratory defects caused by OXA1 mutations &radic0.239840.86274&radic&radic S000000643BUD23YCR047CverifiedProtein involved in bud-site selection; diploid mutants displaya random budding pattern instead of thewild-type bipolar pattern &radic0.238230.86192&radic&radic S000005765ABP140YOR239WverifiedNonessential protein that binds actin filaments and localizesto actin patches and cables, has similarity toS-adenosylmethionine (AdoMet)-dependentmethyltransferases &radic0.232140.85837&radic&radic&radic&radic S000005456COQ3YOL096CverifiedO-methyltransferase, catalyzes two different O-methylationsteps in ubiquinone (Coenzyme Q) biosynthesis;component of a mitochondrialubiquinone-synthesizing complex &radic0.224750.85151&radic&radic S000001106SSZ1YHR064CverifiedHsp70 protein that interacts with Zuo1p (a DnaJ homolog) toform a ribosome-associated complex that bindsthe ribosome via the Zuo1p subunit; alsoinvolved in pleiotropic drug resistance viasequential activation of PDR1 and PDR5; bindsATP 0.207880.83468&radic&radic S000003874RSM7YJR113CverifiedMitochondrial ribosomal protein of the small subunit, hassimilarity to E. coli S7 ribosomal protein 0.204130.83134 S000004940YMR321CUncharacterizedHypothetical protein 0.195990.81961 S000005007MTQ1YNL063WuncharacterizedS-adenosylmethionine-dependent Methyltransferase; methylatestranslational release factor Mrf1p; similar toE.coli PrmC; is not an essential gene &radic0.189090.81477 S000000265TRM7YBR061Cverified2'-O-ribose methyltransferase, methylates the 2'-O-ribose ofnucleotides at positions 32 and 34 of the tRNAanticodon loop &radic0.1810.80529&radic&radic&radic&radic S000003104MRM2YGL136CverifiedMitochondrial 21S rRNA methyltransferase, required formethylation of U(2791) in 21S rRNA; MRM2deletion confers thermosensitive respirationand loss of mitochondrial DNA; has similarityto Spb1p and Trm7p, and to E. coli FtsJ/RrmJ &radic0.171950.79601 S000005005NOP2YNL061WverifiedProbable RNA m(5)C methyltransferase, essential for processingand maturation of 27S pre-rRNA and largeribosomal subunit biogenesis; localized to thenucleolus; constituent of 66S pre-ribosomalparticles &radic0.170410.79505&radic&radic S000003233YGR001CUncharacterizedPutative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae &radic0.16110.7814&radic&radic S000004048SHM2YLR058CverifiedCytosolic serine hydroxymethyltransferase, involved inone-carbon metabolism &radic0.155250.77625&radic&radic&radic&radic&radic S000000467SHM1YBR263WverifiedMitochondrial serine hydroxymethyltransferase, involved inone-carbon metabolism &radic0.152310.77167 S000000560KAR4YCL055WverifiedTranscription factor required for gene regulation in repsonseto pheromones; also required during meiosis;exists in two forms, a slower-migrating formmore abundant during vegetative growth and afaster-migrating form induced by pheromone 0.1430.75737&radic&radic&radic&radic&radic&radic&radic S000004464TRM12YML005WverifiedS-adenosylmethionine-dependent methyltransferase of the sevenbeta-strand family; required for wybutosineformation in phenylalanine-accepting tRNA &radic0.133610.7427&radic&radic&radic&radic&radic S000002816ADE8YDR408CverifiedPhosphoribosyl-glycinamide transformylase, catalyzes a step inthe 'de novo' purine nucleotide biosyntheticpathway &radic0.126580.73017&radic&radic&radic S000001112TRM5YHR070WverifiedtRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacentto the anticodon that has a role in preventionof frameshifting; highly conserved acrossArchaea, Bacteria, and Eukarya &radic0.126060.72973&radic&radic&radic&radic&radic&radic&radic S000004967YNL022CUncharacterizedPutative protein of unknown function with seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to a single spot in the nucleus; YNL022C is not an essential gene 0.120140.72024&radic&radic&radic S000005333LYS9YNR050CverifiedSaccharopine dehydrogenase (NADP+, L-glutamate-forming);catalyzes the formation of saccharopine fromalpha-aminoadipate 6-semialdehyde, which is theseventh step in lysine biosynthesis pathway 0.117520.71405&radic S000005501PPM2YOL141WverifiedPutative carboxyl methyl transferase, has similarity to Ppm1pbut biochemical activity not yet demonstrated;the authentic, non-tagged protein is detectedin highly purified mitochondria inhigh-throughput studies &radic0.117040.71405&radic&radic&radic S000004822YMR209CUncharacterizedPutative protein of unknown function; YMR209C is not an essential gene 0.116890.71316&radic S000006187DIM1YPL266WverifiedEssential 18S rRNA dimethylase, responsible for conservedm6(2)Am6(2)A dimethylation in 3'-terminal loopof 18 S rRNA, part of 90S and 40S pre-particlesin nucleolus, involved in pre-ribosomal RNAprocessing &radic0.113910.70714&radic&radic&radic&radic&radic S000003666URA2YJL130CverifiedBifunctional carbamoylphosphate synthetase (CPSase)-aspartatetranscarbamylase (ATCase), catalyzes the firsttwo enzymatic steps in the de novo biosynthesisof pyrimidines; both activities are subject tofeedback inhibition by UTP &radic0.10560.69172&radic&radic&radic&radic&radic S000002843PPM1YDR435CverifiedCarboxyl methyl transferase, methylates the C terminus of theprotein phosphatase 2A catalytic subunit(Pph21p or Pph22p), which is important forcomplex formation with regulatory subunits &radic0.104220.6898&radic&radic&radic S000006012GLR1YPL091WverifiedCytosolic and mitochondrial glutathione oxidoreductase,converts oxidized glutathione to reducedglutathione 0.097890.67881&radic&radic&radic&radic S000001876LPD1YFL018CverifiedDihydrolipoamide dehydrogenase, the lipoamide dehydrogenasecomponent (E3) of the pyruvate dehydrogenaseand 2-oxoglutarate dehydrogenase multi-enzymecomplexes 0.090910.65838&radic&radic&radic&radic S000003985MHT1YLL062CverifiedS-methylmethionine-homocysteine methyltransferase, functionsalong with Sam4p in the conversion ofS-adenosylmethionine (AdoMet) to methionine tocontrol the methionine/AdoMet ratio &radic0.085910.64503&radic&radic&radic S000006194SAM4YPL273WverifiedS-adenosylmethionine-homocysteine methyltransferase, functionsalong with Mht1p in the conversion ofS-adenosylmethionine (AdoMet) to methionine tocontrol the methionine/AdoMet ratio &radic0.084610.64108&radic&radic&radic&radic&radic S000000120NCL1YBL024WverifiedS-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase,methylates cytosine to m5C at several positionsin tRNAs and intron-containing pre-tRNAs;similar to Nop2p and human proliferationassociated nucleolar protein p120 &radic0.083190.63726&radic&radic&radic&radic&radic S000004841MTF1YMR228WverifiedMitochondrial RNA polymerase specificity factor with structuralsimilarity to S-adenosylmethionine-dependentmethyltransferases and functional similarity tobacterial sigma-factors, interacts withmitochondrial core polymerase Rpo41p &radic0.079740.6284&radic&radic&radic&radic S000003145YGL177WDubiousHypothetical protein 0.072250.60068&radic&radic&radic S000003322UTP22YGR090WuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.070230.5936&radic S000002607YDR199WDubiousHypothetical protein 0.066950.58231&radic&radic&radic S000000109FMT1YBL013WverifiedMethionyl-tRNA formyltransferase, catalyzes the formylation ofinitiator Met-tRNA in mitochondria; potentialCdc28p substrate &radic0.065440.57802&radic&radic S000001069RPN1YHR027CverifiedNon-ATPase base subunit of the 19S regulatory particle of the26S proteasome; may participate in therecognition of several ligands of theproteasome; contains a leucine-rich repeat(LRR) domain, a site for protein?proteininteractions 0.063530.56872&radic&radic&radic&radic&radic S000005329TRM112YNR046WverifiedSubunit of an adoMet-dependent tRNA methyltransferase (MTase)complex (Trm11p-Trm112p), required for themethylation of the guanosine nucleotide atposition 10 (m2G10) in tRNAs; putative zincbinding subunit of other MTase-related proteins &radic0.062720.56737&radic&radic S000001777MET1YKR069WverifiedS-adenosyl-L-methionine uroporphyrinogen III transmethylase,involved in sulfate assimilation, methioninemetabolism, and siroheme biosynthesis &radic0.057830.54743&radic&radic S000003704SET2YJL168CverifiedHistone methyltransferase with a role in transcriptionalelongation, methylates a lysine residue ofhistone H3; associates with the C-terminaldomain of Rpo21p; histone methylation activityis regulated by phosphorylation status ofRpo21p &radic0.054950.53532&radic&radic&radic&radic&radic S000003624ARG3YJL088WverifiedOrnithine carbamoyltransferase (carbamoylphosphate:L-ornithinecarbamoyltransferase), catalyzes the sixth stepin the biosynthesis of the arginine precursorornithine &radic0.053890.52874&radic&radic&radic&radic&radic S000003870CPA2YJR109CverifiedLarge subunit of carbamoyl phosphate synthetase, whichcatalyzes a step in the synthesis ofcitrulline, an arginine precursor 0.052170.51611&radic&radic&radic S000005527RRP6YOR001WverifiedExonuclease component of the nuclear exosome; contributes tothe quality-control system that retains anddegrades aberrant mRNAs in the nucleus 0.0490.50298&radic&radic&radic&radic&radic&radic S000001219FMO1YHR176WverifiedFlavin-containing monooxygenase, localized to the cytoplasmicface of the ER membrane; catalyzes oxidation ofbiological thiols to maintain the ER redoxbuffer ratio for correct folding ofdisulfide-bonded proteins 0.044680.48165&radic&radic S000004754TIF34YMR146CverifiedSubunit of the core complex of translation initiation factor3(eIF3), which is essential for translation 0.041610.47091&radic&radic&radic&radic S000000302MMS4YBR098WverifiedSubunit of the structure-specific Mms4p-Mus81p endonucleasethat cleaves branched DNA; involved inrecombination and DNA repair 0.037820.45667&radic&radic&radic&radic&radic S000003983GTT2YLL060CverifiedGlutathione S-transferase capable of homodimerization;functional overlap with Gtt2p, Grx1p, and Grx2p 0.03710.45295&radic&radic&radic S000002910SAM2YDR502CverifiedS-adenosylmethionine synthetase, catalyzes transfer of theadenosyl group of ATP to the sulfur atom ofmethionine; one of two differentially regulatedisozymes (Sam1p and Sam2p) 0.036510.45106&radic S000006373JIP5YPR169WuncharacterizedNucleolar protein of unknown function, exhibits a physicalinteraction with Bre1p 0.034840.44238&radic&radic&radic&radic S000001953YFR057WUncharacterizedHypothetical protein 0.03430.43807&radic&radic&radic S000001308MET30YIL046WverifiedF-box protein containing five copies of the WD40 motif,controls cell cycle function, sulfurmetabolism, and methionine biosynthesis as partof the ubiquitin ligase complex; interacts withand regulates Met4p, localizes within thenucleus 0.033890.43807&radic&radic&radic&radic&radic&radic S000005261PFS2YNL317WverifiedIntegral subunit of the pre-mRNA cleavage and polyadenylationfactor (CPF) complex; plays an essential rolein mRNA 3'-end formation by bridging differentprocessing factors and thereby promoting theassembly of the processing complex 0.033840.43807&radic&radic&radic S000002271ATG20YDL113CverifiedProtein required for transport of aminopeptidase I (Lap4p)through the cytoplasm-to-vacuole targetingpathway; bindsphosphatidylinositol-3-phosphate, involved inlocalization of membranes to thepreautophagosome, potential Cdc28p substrate 0.033640.43661&radic&radic S000000867ICL1YER065CverifiedIsocitrate lyase, catalyzes the formation of succinate andglyoxylate from isocitrate, a key reaction ofthe glyoxylate cycle; expression of ICL1 isinduced by growth on ethanol and repressed bygrowth on glucose 0.033510.43352&radic&radic S000002744YDR336WUncharacterizedPutative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene 0.033090.43352&radic&radic&radic S000000288MIS1YBR084WverifiedMitochondrial C1-tetrahydrofolate synthase, involved ininterconversion between different oxidationstates of tetrahydrofolate (THF); providesactivities of formyl-THF synthetase,methenyl-THF cyclohydrolase, and methylene-THFdehydrogenase 0.032240.42879 S000003200YGL231CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum 0.031270.42516&radic&radic&radic&radic&radic S000003781YJR020WDubiousHypothetical protein 0.031040.42419&radic&radic S000006383HDA3YPR179CverifiedSubunit of a possibly tetrameric trichostatin A-sensitive classII histone deacetylase complex that contains anHda1p homodimer and an Hda2p-Hda3p heterodimer;required for the activity of the complex; hassimilarity to Hda2p 0.030070.41758&radic&radic&radic&radic S000003432ELP2YGR200CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;target of Kluyveromyces lactis zymocin 0.030050.41758&radic&radic&radic&radic&radic&radic&radic S000002243NDE2YDL085WverifiedMitochondrial external NADH dehydrogenase, catalyzes theoxidation of cytosolic NADH; Nde1p and Nde2pare involved in providing the cytosolic NADH tothe mitochondrial respiratory chain 0.030520.41758&radic S000005263YNL319WDubiousDubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14 0.029940.41568&radic&radic&radic&radic&radic S000001905GCN20YFR009WverifiedPositive regulator of the Gcn2p kinase activity, forms acomplex with Gcn1p; proposed to stimulate Gcn2pactivation by an uncharged tRNA 0.029020.40929&radic&radic&radic&radic S000004012SDO1YLR022CuncharacterizedEssential protein involved in RNA metabolism, one of two yeasthomologs (with Yhr087wp) of the human proteinSBDS responsible for autosomal recessiveShwachman-Bodian-Diamond Syndrome, alsoconserved in Archaea 0.028020.40479&radic&radic&radic&radic S000004470SPT5YML010WverifiedProtein that forms a complex with Spt4p and mediates bothactivation and inhibition of transcriptionelongation; Spt4p-Spt5p complex also plays arole in pre-mRNA processing 0.028370.40479&radic&radic&radic&radic S000004162DPH5YLR172CverifiedMethyltransferase required for synthesis of diphthamide, whichis a modified histidine residue of translationelongation factor 2 (Eft1p or Eft2p); notessential for viability; GFP-Dph5p fusionprotein localizes to the cytoplasm &radic0.027090.39766&radic&radic&radic S000003181SKI8YGL213CverifiedProtein involved in exosome mediated 3' to 5' mRNA degradationand translation inhibition of non-poly(A) mRNAsas well as double-strand break formation duringmeiotic recombination; required for repressingpropagation of dsRNA viruses 0.02650.39526&radic&radic&radic&radic&radic&radic S000001587GFA1YKL104CverifiedGlutamine-fructose-6-phosphate amidotransferase, catalyzes theformation of glucosamine-6-P and glutamate fromfructose-6-P and glutamine in the first step ofchitin biosynthesis 0.025920.38911&radic S000000313CMD1YBR109CverifiedCalmodulin; Ca++ binding protein that regulates Ca++independent processes (mitosis, bud growth,actin organization, endocytosis, etc.) and Ca++dependent processes (stress-activatedpathways), targets include Nuf1p, Myo2p andcalcineurin 0.025530.38764&radic&radic S000005552BUB3YOR026WverifiedKinetochore checkpoint WD40 repeat protein that localizes tokinetochores during prophase and metaphase,delays anaphase in the presence of unattachedkinetochores; forms complexes with Mad1p-Bub1pand with Cdc20p, binds Mad2p and Mad3p 0.025440.38703&radic&radic&radic&radic&radic S000001305CBR1YIL043CverifiedMicrosomal cytochrome b reductase, not essential for viability;also detected in mitochondria; mutation inconserved NADH binding domain of the humanortholog results in type I methemoglobinemia 0.024140.37639&radic&radic&radic&radic S000004165CBF5YLR175WverifiedPseudouridine synthase catalytic subunit of box H/ACA smallnucleolar ribonucleoprotein particles(snoRNPs), acts on both large and small rRNAsand on snRNA U2 0.024550.37639&radic&radic&radic&radic&radic&radic S000003934SOF1YLL011WverifiedEssential subunit of the U3 (box C+D) snRNP complex requiredfor 2' O-methylation of pre-RNA; has similarityto the beta subunit of trimeric G-proteins andthe splicing factor Prp4p 0.024560.37639&radic&radic&radic&radic&radic S000003201TAN1YGL232WverifiedPutative tRNA acetyltransferase, RNA-binding protein requiredfor the formation of the modified nucleosideN(4)-acetylcytidine in serine and leucine tRNAsbut not required for the same modification in18S rRNA 0.024520.37639&radic&radic&radic&radic&radic&radic&radic&radic&radic S000000825PRO3YER023WverifiedDelta 1-pyrroline-5-carboxylate reductase, catalyzes the laststep in proline biosynthesis 0.024030.37521&radic&radic&radic&radic S000003778ESS1YJR017CverifiedPeptidylprolyl-cis/trans-isomerase (PPIase) specific forphosphorylated serine and threonine residuesN-terminal to proline; regulatesphosphorylation of the RNA polymerase II largesubunit (Rpo21p) C-terminal domain 0.02360.37027&radic&radic&radic&radic S000002790RPP2BYDR382WverifiedRibosomal protein P2 beta, a component of the ribosomal stalk,which is involved in the interaction betweentranslational elongation factors and theribosome; regulates the accumulation of P1(Rpp1Ap and Rpp1Bp) in the cytoplasm 0.023310.36967&radic&radic&radic S000001607SSH4YKL124WverifiedProtein whose overexpression confers resistance to the growthinhibitor leflunomide; suppressor of shr3mutation 0.022980.36806&radic&radic&radic S000002764SPC110YDR356WverifiedInner plaque spindle pole body (SPB) component, ortholog ofhuman kendrin; involved in connecting nuclearmicrotubules to SPB; interacts withTub4p-complex and calmodulin; phosphorylated byMps1p in cell cycle-dependent manner 0.022820.36661&radic S000005228MRPL10YNL284CverifiedMitochondrial ribosomal protein of the large subunit; appearsas two protein spots (YmL10 and YmL18) ontwo-dimensional SDS gels 0.022260.36203 S000001052RPL27AYHR010WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl27Bp and has similarity to ratL27 ribosomal protein 0.022010.35988&radic&radic&radic&radic&radic&radic&radic S000002229IRC1YDL071CdubiousHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 0.021730.35842&radic&radic&radic S000002226YDL068WDubiousHypothetical protein 0.021740.35842&radic&radic&radic S000004021YLR031WUncharacterizedHypothetical protein 0.021660.3569&radic&radic&radic S000000142PSY4YBL046WverifiedPutative regulatory subunit of an evolutionarily conservedprotein phosphatase complex containing thecatalytic subunit Pph3p and a third subunitPsy2p; required for cisplatin resistance;GFP-fusion protein localizes to the nucleus 0.021210.35245&radic S000004045SPT8YLR055CverifiedSubunit of the SAGA transcriptional regulatory complex but notpresent in SAGA-like complex SLIK/SALSA,required for SAGA-mediated inhibition at somepromoters 0.020480.34643&radic&radic&radic S000005888PRT1YOR361CverifiedSubunit of the core complex of translation initiation factor3(eIF3), essential for translation; part of asubcomplex (Prt1p-Rpg1p-Nip1p) that stimulatesbinding of mRNA and tRNA(i)Met to ribosomes 0.020510.34643&radic&radic S000005829CPA1YOR303WverifiedSmall subunit of carbamoyl phosphate synthetase, whichcatalyzes a step in the synthesis ofcitrulline, an arginine precursor;translationally regulated by an attenuatorpeptide encoded by YOR302W within the CPA1 mRNA5'-leader 0.020410.34643&radic S000000104HIR1YBL008WverifiedNon-essential transcriptional corepressor involved in the cellcycle-regulated transcription of histone H2A,H2B, H3 and H4 genes; contributes to nucleosomeformation, heterochromatic gene silencing, andformation of functional kinetochores 0.02020.34365&radic&radic&radic&radic&radic S000006339CTF4YPR135WverifiedChromatin-associated protein, required for sister chromatidcohesion; interacts with DNA polymerase alpha(Pol1p) and may link DNA synthesis to sisterchromatid cohesion 0.020260.34365&radic&radic&radic S000006341RRP9YPR137WverifiedProtein involved in pre-rRNA processing, associated with U3snRNP; component of small ribosomal subunit(SSU) processosome; ortholog of the humanU3-55k protein 0.019850.34096&radic&radic&radic&radic&radic S000000544GID7YCL039WverifiedProtein of unknown function, involved in proteasome-dependentcatabolite inactivation offructose-1,6-bisphosphatase; contains six WD40repeats; computational analysis suggests thatGid7p and Moh1p have similar functions 0.01980.34096&radic&radic&radic&radic S000004277YLR287CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene 0.019760.34096&radic&radic&radic&radic&radic S000003622YJL086CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1 0.019740.34096&radic&radic&radic S000005756WTM1YOR230WverifiedTranscriptional repressor involved in regulation of meiosis andsilencing; contains WD repeats 0.01980.34096&radic&radic&radic&radic S000000472MRPL37YBR268WverifiedMitochondrial ribosomal protein of the large subunit 0.019490.33852&radic&radic&radic S000002653MNN10YDR245WverifiedSubunit of a Golgi mannosyltransferase complex also containingAnp1p, Mnn9p, Mnn11p, and Hoc1p that mediateselongation of the polysaccharide mannanbackbone; membrane protein of themannosyltransferase family 0.019490.33852&radic&radic&radic S000004914DYN3YMR299CverifiedDynein light intermediate chain (LIC); localizes with dynein,null mutant is defective in nuclear migration 0.019290.33745&radic&radic&radic&radic&radic&radic&radic S000005171JJJ1YNL227CverifiedProtein that contains a 70 amino acid J-domain, may function asa co-chaperone to recruit Hsp70-like activityto specific sites; mutation causes defects influid-phase endocytosis 0.019250.33673&radic&radic&radic&radic&radic S000000794YEL068CDubiousHypothetical protein 0.019170.33646&radic&radic&radic&radic S000001029YHL037CDubiousHypothetical protein 0.018910.3342&radic&radic&radic&radic&radic S000004186PWP1YLR196WverifiedProtein with WD-40 repeats involved in rRNA processing;associates with trans-acting ribosomebiogenesis factors; similar to beta-transducinsuperfamily 0.018830.3337&radic&radic S000001034YHL042WUncharacterizedPutative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins 0.018770.33194&radic&radic S000002904PUF6YDR496CverifiedPumilio-homology domain protein that binds ASH1 mRNA at PUFconsensus sequences in the 3' UTR and repressesits translation, resulting in proper asymmetriclocalization of ASH1 mRNA 0.01840.32984&radic&radic S000004781YMR171CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to endosomes; mRNA is targeted to the bud via the mRNA transport system involving She2p: YMR171C is not an essential gene 0.018090.32607&radic&radic&radic S000002254OPI6YDL096CdubiousDubious open reading frame unlikely to encode a protein, basedon available experimental and comparativesequence data; partially overlaps verified genePMT1/YDL095W; YDL096C is not essential 0.018180.32607&radic&radic&radic S000000399MSI1YBR195CverifiedSubunit of chromatin assembly factor I (CAF-I), regulates theRAS/cAMP pathway via sequestration of Npr1pkinase; localizes to the nucleus and cytoplasm;homologous to human retinoblastoma bindingproteins RbAp48 and RbAp46 0.018250.32607&radic&radic&radic&radic&radic&radic S000003623TRL1YJL087CverifiedtRNA ligase, required for tRNA splicing; composed of threeessential domains containing thephosphodiesterase, polynucleotide kinase, andligase activities required for ligation;localized at the inner membrane of the nuclearenvelope 0.018210.32607&radic&radic&radic&radic S000002840NPL3YDR432WverifiedRNA-binding protein that carries poly(A)+ mRNA from the nucleusinto the cytoplasm; phosphorylation by Sky1p inthe cytoplasm may promote release of mRNAs 0.01790.32585&radic&radic&radic&radic&radic&radic S000002505GRX3YDR098CverifiedHydroperoxide and superoxide-radical responsiveglutathione-dependent oxidoreductase; monothiolglutaredoxin subfamily member along with Grx4pand Grx5p; protects cells from oxidative damage 0.017730.32346&radic&radic&radic&radic&radic S000004758IMP1YMR150CverifiedCatalytic subunit of the mitochondrial inner membrane peptidasecomplex, required for maturation ofmitochondrial proteins of the intermembranespace; complex contains Imp1p and Imp2p (bothcatalytic subunits), and Som1p 0.017690.32346&radic&radic&radic&radic&radic&radic S000004846YMR233WUncharacterizedProtein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; YMR233W is not an essential gene 0.01760.32308&radic&radic&radic&radic&radic&radic&radic&radic S000003196VID30YGL227WverifiedProtein involved in proteasome-dependent catabolite degradationof fructose-1,6-bisphosphatase (FBPase); shiftsthe balance of nitrogen metabolism toward theproduction of glutamate; localized to thenucleus and the cytoplasm 0.017380.32076&radic&radic&radic&radic&radic&radic S000002782YDR374CUncharacterizedHypothetical protein 0.017440.32076&radic&radic&radic&radic&radic S000000798RMD6YEL072WverifiedProtein required for sporulation 0.017460.32076&radic&radic&radic&radic S000002459DBF4YDR052CverifiedRegulatory subunit of Cdc7p-Dbf4p kinase complex, required forCdc7p kinase activity and initiation of DNAreplication; phosphorylates the Mcm2-7 familyof proteins; cell cycle regulated 0.017440.32076&radic&radic&radic S000004119DIP2YLR129WverifiedNucleolar protein, specifically associated with the U3 snoRNA,part of the large ribonucleoprotein complexknown as the small subunit (SSU) processome,required for 18S rRNA biogenesis, part of theactive pre-rRNA processing complex 0.017270.31766&radic&radic&radic&radic&radic S000001070DAP2YHR028CverifiedDipeptidyl aminopeptidase, synthesized as a glycosylatedprecursor; localizes to the vacuolar membrane;similar to Ste13p 0.017350.31766&radic&radic&radic&radic&radic&radic S000001566YKL083WDubiousDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14 0.017290.31766&radic&radic&radic&radic S000001153UBA4YHR111WverifiedProtein that activates Urm1p before its conjugation to proteins(urmylation); one target is the thioredoxinperoxidase Ahp1p, suggesting a role ofurmylation in the oxidative stress response 0.017010.3174&radic&radic&radic&radic&radic S000000183RPL23AYBL087CverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl23Bp and has similarity to E.coli L14 and rat L23 ribosomal proteins 0.016880.31627&radic&radic&radic&radic S000006382PRP4YPR178WverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.016740.31427&radic&radic&radic&radic&radic&radic&radic S000004389AFG2YLR397CverifiedATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexamericcomplex; may be involved in degradation ofaberrant mRNAs 0.016750.31427&radic&radic&radic&radic S000006384AOS1YPR180WverifiedNuclear protein that acts as a heterodimer with Uba2p toactivate Smt3p (SUMO) before its conjugation toproteins (sumoylation), which may play a rolein protein targeting; essential for viability 0.016570.31278&radic&radic&radic&radic&radic&radic S000005738STE4YOR212WverifiedG protein beta subunit, forms a dimer with Ste18p to activatethe mating signaling pathway, forms aheterotrimer with Gpa1p and Ste18p to dampensignaling; may recruit Rho1p to the polarizedgrowth site during mating; contains WD40repeats 0.016520.31278&radic&radic&radic S000003413TIM13YGR181WverifiedMitochondrial intermembrane space protein, forms a complex withTIm8p that mediates import and insertion of asubset of polytopic inner membrane proteins;may prevent aggregation of incoming proteins ina chaperone-like manner 0.016480.31278&radic&radic&radic&radic&radic S000000462SHG1YBR258CverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres &radic0.016350.31161&radic&radic&radic&radic&radic&radic S000002580ARG82YDR173CverifiedInositol polyphosphate multikinase (IPMK), sequentiallyphosphorylates Ins(1,4,5)P3 to formIns(1,3,4,5,6)P5; putative nuclear lipidinositol PI3-kinase; regulates arginine-,phosphate-, and nitrogen-responsive genes 0.016330.31017&radic&radic&radic&radic&radic S000002493SSS1YDR086CverifiedSubunit of the Sec61p translocation complex(Sec61p-Sss1p-Sbh1p) that forms a channel forpassage of secretory proteins through theendoplasmic reticulum membrane, and of theSsh1p complex (Ssh1p-Sbh2p-Sss1p); interactswith Ost4p and Wbp1p 0.016330.31017&radic&radic S000004871YMR258CUncharacterizedProtein of unknown function with similarity to F-box proteins; physically interacts with Skp1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR258C is not an essential gene 0.016340.31017&radic&radic&radic&radic&radic&radic&radic&radic&radic S000006168YPL247CUncharacterizedHypothetical protein 0.015960.3056&radic&radic&radic&radic&radic S000003491YGR259CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W 0.015720.30353&radic&radic&radic&radic&radic S000004852RNT1YMR239CverifiedRNAase III; cleaves a stem-loop structure at the 3' end of U2snRNA to ensure formation of the correct U2 3'end 0.015820.30353&radic&radic&radic&radic&radic&radic&radic&radic&radic S000004255NEJ1YLR265CverifiedProtein involved in regulation of nonhomologous end joining;repressed by MAT heterozygosity; associateswith Lif1p and regulates its cellulardistribution 0.015680.30353&radic&radic&radic&radic&radic S000000773YEL047CVerifiedFumurate ReDuctase Soluble 0.015430.3002&radic&radic&radic&radic S000005355HXT17YNR072WverifiedHexose transporter, up-regulated in media containing raffinoseand galactose at pH 7.7 versus pH 4.7,repressed by high levels of glucose 0.015480.3002&radic&radic S000001805PCK1YKR097WverifiedPhosphoenolpyruvate carboxykinase, key enzyme ingluconeogenesis, catalyzes early reaction incarbohydrate biosynthesis, glucose repressestranscription and accelerates mRNA degradation,regulated by Mcm1p and Cat8p, located in thecytosol 0.015420.3002 S000000470SLM6YBR266CdubiousProtein with a potential role in actin cytoskeletonorganization; gene exhibits synthetic geneticinteraction with MSS4 encodingphosphatidylinositol 4-phosphate kinase 0.015270.29992&radic&radic S000005685SME1YOR159CverifiedCore Sm protein Sm E; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm E 0.015210.29918&radic&radic&radic S000006161HSP82YPL240CverifiedCytoplasmic chaperone (Hsp90 family) required for pheromonesignaling and negative regulation of Hsf1p;docks with the mitochondrial import receptorTom70p for preprotein delivery; interacts withco-chaperones Cns1p, Cpr6p, Cpr7p, and Sti1p 0.014950.29625&radic&radic&radic&radic S000002831CAD1YDR423CverifiedAP-1-like bZIP transcriptional activator involved in multiplestress responses, iron metabolism, andpleiotropic drug resistance; controls a set ofgenes involved in stabilizing proteins, bindsconsensus sequence TTACTAA; 5' UTR containsuORFs 0.014650.29261&radic&radic&radic&radic&radic&radic S000000815PRP22YER013WverifiedDEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase,associates with lariat intermediates before thesecond catalytic step of splicing; mediatesATP-dependent mRNA release from the spliceosomeand unwinds RNA duplexes 0.014720.29261&radic&radic&radic&radic&radic&radic&radic S000005197TEX1YNL253WverifiedProtein involved in mRNA export, component of the transcriptionexport (TREX) complex 0.01460.29259&radic&radic S000003295SPT4YGR063CverifiedProtein that forms a complex with Spt5p and mediates bothactivation and inhibition of transcriptionelongation, and plays a role in pre-mRNAprocessing; in addition, Spt4p is involved inkinetochore function and gene silencing 0.014530.28925&radic S000002538YDR131CUncharacterizedF-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex 0.014390.28925&radic&radic&radic&radic S000004212UTP13YLR222CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.01420.28728&radic&radic S000002944STL1YDR536WverifiedGlycerol proton symporter of the plasma membrane, subject toglucose-induced inactivation, strongly buttransiently induced when cells are subjected toosmotic shock 0.014250.28728&radic&radic&radic&radic&radic S000002787RGA2YDR379WverifiedGTPase-activating protein for the polarity-establishmentprotein Cdc42p; implicated in control of septinorganization, pheromone response, and haploidinvasive growth 0.014240.28728&radic&radic&radic&radic S000002506BMH2YDR099Wverified14-3-3 protein, minor isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others 0.014160.28682&radic&radic&radic&radic S000000438ARC40YBR234CverifiedEssential subunit of the ARP2/3 complex, which is required forthe motility and integrity of cortical actinpatches 0.013870.28407&radic&radic&radic&radic S000001586LAP4YKL103CverifiedVacuolar aminopeptidase, often used as a marker protein instudies of autophagy and cytosol to vacuoletargeting (CVT) pathway 0.013840.28351&radic&radic S000000883SER3YER081Wverified3-phosphoglycerate dehydrogenase, catalyzes the first step inserine and glycine biosynthesis; isozyme ofSer33p 0.013830.28351&radic&radic&radic&radic S000004867YMR254CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data 0.013810.28351&radic&radic&radic S000002572TRM82YDR165WverifiedSubunit of a tRNA methyltransferase complex composed of Trm8pand Trm82p that catalyzes 7-methylguanosinemodification of tRNA &radic0.013580.28107&radic&radic&radic&radic&radic S000005072TEP1YNL128WverifiedHomolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that haslipid phosphatase activity and is linked to thephosphatidylinositol signaling pathway; plays arole in normal sporulation 0.013690.28107&radic&radic&radic S000005145PSY2YNL201CverifiedPutative subunit of an evolutionarily conserved proteinphosphatase complex containing the catalyticsubunit Pph3p and the regulatory subunit Psy4p;required for cisplatin and oxaliplatinresistance; localizes to nucleus 0.013610.28107&radic&radic S000005690YOR164CVerifiedProtein of unknown function; interacts with Mdy2p 0.01330.27697&radic&radic&radic&radic&radic&radic&radic S000004838MRPL44YMR225CverifiedMitochondrial ribosomal protein of the large subunit 0.013490.27697&radic&radic&radic&radic&radic&radic&radic S000005354YNR071CUncharacterizedHypothetical protein 0.013290.27697&radic&radic S000002482PPH3YDR075WverifiedCatalytic subunit of an evolutionarily conserved proteinphosphatase complex containing Psy2p and theregulatory subunit Psy4p; required forcisplatin resistance; involved in activation ofGln3p 0.013490.27697&radic&radic&radic S000002776YPR1YDR368Wverified2-methylbutyraldehyde reductase, may be involved in isoleucinecatabolism 0.013490.27697&radic&radic&radic S000006295YPR091CUncharacterizedHypothetical protein 0.013560.27697&radic&radic&radic S000001148TRR2YHR106WverifiedMitochondrial thioredoxin reductase involved in protectionagainst oxidative stress, required with Glr1pto maintain the redox state of Trx3p, containsactive-site motif (CAVC) present in prokaryoticthioredoxin reductases, binds NADPH and FAD 0.013570.27697&radic S000002972RPN14YGL004CuncharacterizedPutative non-ATPase subunit of the 19S regulatory particle ofthe 26S proteasome; localized to the cytoplasm 0.013360.27697&radic&radic&radic S000003199YGL230CUncharacterizedHypothetical protein 0.01350.27697&radic&radic&radic&radic&radic S000003335NOP7YGR103WverifiedNucleolar protein involved in rRNA processing and 60S ribosomalsubunit biogenesis; constituent of severaldifferent pre-ribosomal particles; required forexit from G0 and the initiation ofcell proliferation 0.013180.27549&radic&radic&radic&radic S000002725HIM1YDR317WverifiedProtein of unknown function involved in DNA repair 0.013170.27549&radic&radic S000004761YMR153C-ADubiousHypothetical protein 0.013190.27549&radic&radic&radic&radic&radic S000001152ERP5YHR110WverifiedProtein with similarity to Emp24p and Erv25p, member of the p24family involved in ER to Golgi transport 0.013140.27519&radic&radic&radic S000004868GFD1YMR255WverifiedCoiled-coiled protein of unknown function, identified as ahigh-copy suppressor of a dbp5 mutation 0.013120.27519&radic&radic&radic&radic&radic&radic S000005439YOL079WDubiousHypothetical protein 0.01310.27483&radic&radic&radic&radic&radic S000002597SLY1YDR189WverifiedHydrophilic protein involved in vesicle trafficking between theER and Golgi; SM (Sec1/Munc-18) family proteinthat binds the tSNARE Sed5p and stimulates itsassembly into a trans-SNARE membrane-proteincomplex 0.012870.27231&radic&radic&radic&radic&radic S000005440REX4YOL080CverifiedPutative RNA exonuclease possibly involved in pre-rRNAprocessing and ribosome assembly 0.012740.26994&radic&radic&radic S000000165AST1YBL069WverifiedPeripheral membrane protein that interacts with the plasmamembrane ATPase Pma1p and has a role in itstargeting to the plasma membrane, possibly byinfluencing its incorporation into lipid rafts 0.012670.26994&radic&radic&radic&radic&radic&radic&radic&radic S000000792HPA3YEL066WverifiedD-Amino acid N-acetyltransferase, catalyzes N-acetylation ofD-amino acids through ordered bi-bi mechanismin which acetyl-CoA is first substrate boundand CoA is last product liberated; similar toHpa2p, acetylates histones weakly in vitro 0.012710.26994&radic&radic&radic&radic&radic S000001504MAK11YKL021CverifiedProtein essential for cell growth and replication of M dsRNAvirus; contains four beta-transducin repeats 0.012580.26917&radic&radic&radic&radic&radic&radic S000003307PRP38YGR075CverifiedUnique component of the U4/U6.U5 tri-snRNP particle,dispensable for spliceosome assembly, butrequired for conformational changes which leadto catalytic activation of the spliceosome 0.012560.26917&radic&radic&radic&radic S000004008POM34YLR018CverifiedIntegral membrane protein of the nuclear pore; has an importantrole in maintaining the architecture of thepore complex 0.012540.26905&radic S000000633PHO87YCR037CverifiedLow-affinity inorganic phosphate (Pi) transporter, involved inactivation of PHO pathway; expression isindependent of Pi concentration and Pho4pactivity; contains 12 membrane-spanningsegments 0.012260.26492&radic&radic S000002535YDR128WUncharacterizedHypothetical protein 0.012360.26492&radic&radic&radic&radic S000004280GUF1YLR289WverifiedMitochondrial GTPase of unknown function, similar to E. colielongation factor-type GTP-binding protein LepAand to LK1236.1 from Caenorhabditis elegans 0.012370.26492&radic&radic&radic&radic&radic S000001604YKL121WUncharacterizedPutative protein of unknown function 0.012280.26492&radic&radic&radic S000003306SMD1YGR074WverifiedCore Sm protein Sm D1; part of heteroheptameric complex (withSmb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D1 0.012470.26492&radic&radic&radic&radic S000006184KEL3YPL263CverifiedCytoplasmic protein of unknown function 0.012250.26492&radic&radic&radic S000004872YMR259CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR259C is not an essential gene 0.012350.26492&radic&radic&radic&radic&radic&radic S000002943YDR535CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene. 0.012530.26492&radic S000000015PSK1YAL017WverifiedOne of two (see also PSK2) PAS domain containing S/T proteinkinases; coordinately regulates proteinsynthesis and carbohydrate metabolism andstorage in response to a unknown metabolitethat reflects nutritional status 0.012130.26147&radic&radic&radic S000000613PET18YCR020CverifiedProtein required for respiratory growth and stability of themitochondrial genome 0.011970.26147&radic&radic&radic&radic&radic&radic S000002743MSN5YDR335WverifiedKaryopherin involved in nuclear import and export; shown to beresponsible for nuclear import of replicationprotein A and for export of several proteinsincluding Swi6p, Far1p, and Pho4p; cargodissociation involves binding to RanGTP 0.011970.26147&radic&radic&radic&radic&radic S000000682CSM1YCR086WverifiedNucleolar protein that forms a complex with Lrs4p which bindsMam1p at kinetochores during meiosis I tomediate accurate chromosome segregation, may beinvolved in premeiotic DNA replication;possible role in telomere maintenance 0.012050.26147&radic&radic&radic S000003749YJL213WUncharacterizedPutative protein of unknown function; periodically expressed during the yeast metabolic cycle; expression induced in respiratory incompetent petite cells; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p 0.012050.26147&radic&radic S000000667IMG2YCR071CverifiedMitochondrial ribosomal protein of the small subunit 0.012060.26147&radic&radic&radic S000005025SWS2YNL081CuncharacterizedPutative mitochondrial ribosomal protein of the small subunit,has similarity to E. coli S13 ribosomal protein 0.012010.26147&radic&radic S000006376YPR172WUncharacterizedProtein of unknown function, transcriptionally activated by Yrm1p along with genes involved in multidrug resistance 0.012020.26147&radic&radic&radic&radic&radic&radic&radic&radic&radic S000002251PMT5YDL093WverifiedProtein O-mannosyltransferase, transfers mannose residues fromdolichyl phosphate-D-mannose to proteinserine/threonine residues; acts in a complexwith Pmt3p, can instead interact with Pmt2p insome conditions; target for new antifungals 0.012110.26147&radic&radic&radic S000002814PDR15YDR406WverifiedATP binding cassette (ABC) transporter of the plasma membrane;general stress response factor implicated incellular detoxification; target of Pdr1p, Pdr3pand Pdr8p transcription regulators; promotercontains a PDR responsive element 0.011880.26042&radic&radic&radic&radic&radic S000001297CKA1YIL035CverifiedAlpha catalytic subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA2, CKB1 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.011870.26042&radic&radic&radic&radic&radic&radic S000001031YHL039WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.01180.2592&radic S000002611YDR203WDubiousHypothetical protein 0.011790.2592&radic&radic&radic&radic&radic&radic S000001694TRP3YKL211CverifiedBifunctional enzyme exhibiting both indole-3-glycerol-phosphatesynthase and anthranilate synthase activities,forms multifunctional hetero-oligomericanthranilate synthase:indole-3-glycerolphosphate synthase enzyme complex with Trp2p 0.011860.2592&radic&radic&radic&radic&radic S000001594YKL111CDubiousDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene ABF1 0.011610.25625&radic&radic&radic&radic&radic&radic S000004652ERB1YMR049CverifiedProtein required for maturation of the 25S and 5.8S ribosomalRNAs; constituent of 66S pre-ribosomalparticles; homologous to mammalian Bop1 0.01160.25625&radic S000005203ATX1YNL259CverifiedCytosolic copper metallochaperone that transports copper to thesecretory vesicle copper transporter Ccc2p foreventual insertion into Fet3p, which is amulticopper oxidase required for high-affinityiron uptake 0.011620.25625&radic&radic&radic&radic&radic S000006331YPR127WUncharacterizedHypothetical protein 0.011450.25513&radic&radic&radic&radic S000000441PRP5YBR237WverifiedRNA helicase in the DEAD-box family, necessary forprespliceosome formation, bridges U1 and U2snRNPs and enables stable U2 snRNP associationwith intron RNA 0.011450.25509&radic&radic&radic&radic&radic S000000884UTP7YER082CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.011380.25117&radic&radic&radic&radic&radic S000003470KEL2YGR238CverifiedProtein that functions in a complex with Kel1p to negativelyregulate mitotic exit, interacts with Tem1p andLte1p; localizes to regions of polarizedgrowth; potential Cdc28p substrate 0.011330.25117 S000001318VHR1YIL056WuncharacterizedTranscriptional activator, required for the vitaminH-responsive element (VHRE) mediated inductionof VHT1 (Vitamin H transporter) and BIO5(biotin biosynthesis intermediate transporter)in response to low biotin concentrations 0.011190.25117&radic&radic S000002494RRP1YDR087CverifiedEssential evolutionarily conserved nucleolar protein necessaryfor biogenesis of 60S ribosomal subunits andprocessing of pre-rRNAs to mature rRNAs,associated with several distinct 66Spre-ribosomal particles 0.011180.25117&radic&radic&radic&radic&radic&radic&radic S000003165MDS3YGL197WverifiedProtein with an N-terminal kelch-like domain, putative negativeregulator of early meiotic gene expression;required, with Pmd1p, for growth under alkalineconditions 0.011350.25117&radic&radic&radic S000004887RCE1YMR274CverifiedType II CAAX prenyl protease involved in the proteolysis andmaturation of Ras and the a-factor matingpheromone 0.011270.25117&radic&radic&radic&radic&radic S000000062SEO1YAL067CverifiedPutative permease, member of the allantoate transportersubfamily of the major facilitator superfamily;mutation confers resistance to ethioninesulfoxide 0.011150.25067&radic&radic&radic&radic S000004279MEC3YLR288CverifiedDNA damage and meiotic pachytene checkpoint protein; subunit ofa heterotrimeric complex (Rad17p-Mec3p-Ddc1p)that forms a sliding clamp, loaded onto partialduplex DNA by a clamp loader complex; homologof human and S. pombe Hus1 0.011070.24916&radic&radic&radic&radic S000002835RPN9YDR427WverifiedNon-ATPase regulatory subunit of the 26S proteasome, hassimilarity to putative proteasomal subunits inother species; null mutant is temperaturesensitive and exhibits cell cycle andproteasome assembly defects 0.011010.24916&radic&radic&radic&radic S000002834YDR426CDubiousHypothetical protein 0.011030.24916&radic&radic&radic&radic&radic&radic S000001201KEL1YHR158CverifiedProtein required for proper cell fusion and cell morphology;functions in a complex with Kel2p to negativelyregulate mitotic exit, interacts with Tem1p andLte1p; localizes to regions of polarizedgrowth; potential Cdc28p substrate 0.011080.24916 S000003723SWE1YJL187CverifiedProtein kinase that regulates the G2/M transition by inhibitionof Cdc28p kinase activity; localizes to thenucleus and to the daughter side of themother-bud neck; homolog of S. pombe Wee1p;potential Cdc28p substrate 0.011050.24916&radic&radic&radic&radic&radic S000003738YJL202CDubiousHypothetical protein; open reading frame overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex 0.011090.24916&radic&radic S000000729GIM4YEL003WverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.011120.24916&radic&radic&radic&radic&radic&radic S000000307SIF2YBR103WverifiedWD40 repeat-containing subunit of the Set3C histone deacetylasecomplex, which represses early/middlesporulation genes; antagonizes telomericsilencing; binds specifically to the Sir4pN-terminus 0.010970.24793&radic&radic S000002971CDH1YGL003CverifiedCell-cycle regulated activator of the anaphase-promotingcomplex/cyclosome (APC/C), which directsubiquitination of mitotic cyclins resulting inexit from mitosis; targets the APC/C tospecific substrates including CDC20, ASE1 andCIN8 0.010970.24793&radic S000000122LSM2YBL026WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.010930.247&radic&radic&radic&radic&radic&radic&radic S000004401UTP21YLR409CuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.01090.247&radic&radic&radic&radic&radic&radic&radic S000000782HAT2YEL056WverifiedSubunit of the Hat1p-Hat2p histone acetyltransferase complex;required for high affinity binding of thecomplex to free histone H4, thereby enhancingHat1p activity; similar to human RbAp46 and 48;has a role in telomeric silencing 0.010870.24634&radic&radic S000005779NAT5YOR253WverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.010820.24542&radic&radic&radic&radic&radic S000001578YJU2YKL095WverifiedEssential nuclear protein; putative spliceosomal componentinvolved in mRNA splicing, based oncomputational analysis of large-scaleprotein-protein interaction data 0.010710.24488&radic&radic&radic&radic S000004818PFK2YMR205CverifiedBeta subunit of heterooctameric phosphofructokinase involved inglycolysis, indispensable for anaerobic growth,activated by fructose-2,6-bisphosphate and AMP,mutation inhibits glucose induction of cellcycle-related genes 0.010650.24336&radic&radic&radic&radic&radic S000000234YBR030WUncharacterizedHypothetical protein 0.010690.24336&radic S000004840TAF7YMR227CverifiedTFIID subunit (67 kDa), involved in RNA polymerase IItranscription initiation 0.010530.24139&radic&radic&radic&radic&radic&radic S000003193VRG4YGL225WverifiedGolgi GDP-mannose transporter; regulates Golgi function andglycosylation in Golgi 0.010520.24139&radic&radic&radic&radic&radic S000004559GIM5YML094WverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.010590.24139&radic&radic&radic&radic S000004009PSR2YLR019WverifiedFunctionally redundant Psr1p homolog, a plasma membranephosphatase involved in the general stressresponse; required with Psr1p and Whi2p forfull activation of STRE-mediated geneexpression, possibly through dephosphorylationof Msn2p 0.010430.24093&radic&radic&radic S000000406CDC47YBR202WverifiedComponent of the hexameric MCM complex, which is important forpriming origins of DNA replication in G1 andbecomes an active ATP-dependent helicase thatpromotes DNA melting and elongation whenactivated by Cdc7p-Dbf4p in S-phase 0.010410.23964&radic&radic&radic&radic&radic&radic&radic S000006104YPL183CUncharacterizedHypothetical protein 0.010360.23964&radic S000003308MRPL25YGR076CverifiedMitochondrial ribosomal protein of the large subunit 0.010410.23964&radic&radic&radic S000002490RRP8YDR083WverifiedNucleolar protein involved in rRNA processing, pre-rRNAcleavage at site A2; also involved in telomeremaintenance; mutation is synthetically lethalwith a gar1 mutation &radic0.010340.23916&radic&radic&radic&radic&radic&radic S000004141PCD1YLR151CverifiedPeroxisomal nudix pyrophosphatase with specificity for coenzymeA and CoA derivatives, may function to removepotentially toxic oxidized CoA disulfide fromperoxisomes to maintain the capacity forbeta-oxidation of fatty acids 0.010320.23916&radic&radic&radic&radic S000003955YLL032CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene 0.010290.23875&radic&radic&radic S000006056ISU1YPL135WverifiedConserved protein of the mitochondrial matrix, performs ascaffolding function during assembly ofiron-sulfur clusters, interacts physically andfunctionally with yeast frataxin (Yfh1p); isu1isu2 double mutant is inviable 0.010280.23807&radic&radic S000005606DIA2YOR080WverifiedOrigin-binding F-box protein that forms an SCF ubiquitin ligasecomplex with Skp1p and Cdc53p; plays a role inDNA replication, involved in invasive andpseudohyphal growth 0.010280.23807&radic&radic&radic&radic&radic S000000957BEM2YER155CverifiedRho GTPase activating protein (RhoGAP) involved in the controlof cytoskeleton organization and cellularmorphogenesis; required for bud emergence 0.010270.23807&radic S000001885CDC4YFL009WverifiedF-box protein required for G1/S and G2/M transition, associateswith Skp1p and Cdc53p to form a complex,SCFCdc4, which acts as ubiquitin-protein ligasedirecting ubiquitination of the phosphorylatedCDK inhibitor Sic1p 0.010220.23692&radic&radic S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.010210.23692&radic&radic&radic&radic&radic&radic&radic S000006047NAN1YPL126WverifiedU3 snoRNP protein, component of the small (ribosomal) subunit(SSU) processosome containing U3 snoRNA;required for the biogenesis of18S rRNA 0.010230.23692&radic&radic&radic&radic S000000330TPS1YBR126CverifiedSynthase subunit of trehalose-6-phosphate synthase/phosphatasecomplex, which synthesizes the storagecarbohydrate trehalose; also found in amonomeric form; expression is induced by thestress response and repressed by the Ras-cAMPpathway 0.010180.23692&radic&radic S000003084CDC20YGL116WverifiedCell-cycle regulated activator of anaphase-promotingcomplex/cyclosome (APC/C), which is requiredfor metaphase/anaphase transition; directsubiquitination of mitotic cyclins, Pds1p, andother anaphase inhibitors; potential Cdc28psubstrate 0.010230.23692&radic&radic&radic&radic S000000653PWP2YCR057CverifiedConserved 90S pre-ribosomal component essential for properendonucleolytic cleavage of the 35 S rRNAprecursor at A0, A1, and A2 sites; containseight WD-repeats; PWP2 deletion leads todefects in cell cycle and bud morphogenesis 0.010210.23692 S000001737SET3YKR029CverifiedDefining member of the SET3 histone deacetylase complex whichis a meiosis-specific repressor of sporulationgenes; necessary for efficient transcription byRNAPII; one of two yeast proteins that containsboth SET and PHD domains 0.01020.23692&radic S000005999ATP4YPL078CverifiedSubunit b of the stator stalk of mitochondrial F1F0 ATPsynthase, which is a large, evolutionarilyconserved enzyme complex required for ATPsynthesis 0.010150.23472&radic&radic&radic&radic&radic&radic&radic&radic S000000421ATG12YBR217WverifiedUbiquitin-like modifier, conjugated via an isopeptide bond to alysine residue of Atg5p by the E1 enzyme,Atg7p, and the E2 enzyme, Atg10p, a step thatis essential for autophagy 0.009990.23407&radic&radic&radic&radic S000001104RPP1YHR062CverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends 0.009920.23286&radic&radic&radic&radic&radic&radic S000005895RAD17YOR368WverifiedCheckpoint protein, involved in the activation of the DNAdamage and meiotic pachytene checkpoints; withMec3p and Ddc1p, forms a clamp that is loadedonto partial duplex DNA; homolog of human andS. pombe Rad1 and U. maydis Rec1 proteins 0.009920.23286&radic&radic&radic&radic&radic&radic&radic S000001494CCE1YKL011CverifiedMitochondrial cruciform cutting endonuclease, cleaves Hollidayjunctions formed during recombination ofmitochondrial DNA 0.009920.23286&radic&radic&radic S000000683YCR087WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene 0.009910.23225&radic&radic&radic S000003030PYC1YGL062WverifiedPyruvate carboxylase isoform, cytoplasmic enzyme that convertspyruvate to oxaloacetate; highly similar toisoform Pyc2p but differentially regulated;mutations in the human homolog are associatedwith lactic acidosis 0.009880.23051&radic&radic&radic S000004376IKI3YLR384CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;maintains structural integrity of Elongator;homolog of human IKAP, mutations in which causefamilial dysautonomia (FD) 0.009850.23051&radic&radic&radic&radic&radic S000002603REF2YDR195WverifiedRNA-binding protein involved in the cleavage step of mRNA3'-end formation prior to polyadenylation, andin snoRNA maturation; part of holo-CPFsubcomplex APT, which associates with 3'-endsof snoRNA- and mRNA-encoding genes 0.00980.23051&radic&radic&radic S000004759YIM2YMR151WdubiousDubious open reading frame, unlikely to encode a protein; notconserved in closely related Saccharomycesspecies; 5% of ORF overlaps the verified geneIMP1 0.009860.23051&radic&radic&radic S000005030YNL086WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to endosomes 0.009880.23051&radic&radic S000002918SMT3YDR510WverifiedUbiquitin-like protein of the SUMO family, conjugated to lysineresidues of target proteins; regulateschromatid cohesion, chromosome segregation,APC-mediated proteolysis, DNA replication andseptin ring dynamics 0.009650.22804&radic&radic S000003450CRM1YGR218WverifiedMajor karyopherin, involved in export of proteins, RNAs, andribosomal subunits from the nucleus 0.009740.22804&radic&radic&radic&radic&radic&radic S000005561SHE4YOR035CverifiedProtein containing a UCS (UNC-45/CRO1/SHE4) domain, binds tomyosin motor domains to regulate myosinfunction; involved in endocytosis, polarizationof the actin cytoskeleton, and asymmetric mRNAlocalization 0.009660.22804&radic&radic&radic&radic&radic S000002618YDR210WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery 0.009670.22804&radic&radic S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling 0.009640.2279&radic&radic&radic&radic&radic&radic&radic&radic&radic&radic S000005006GCD10YNL062CverifiedSubunit of tRNA (1-methyladenosine) methyltransferase withGcd14p, required for the modification of theadenine at position 58 in tRNAs, especiallytRNAi-Met; first identified as a negativeregulator of GCN4 expression &radic0.009640.2279&radic&radic S000003661GCD14YJL125CverifiedSubunit of tRNA (1-methyladenosine) methyltransferase, withGcd10p, required for the modification of theadenine at position 58 in tRNAs, especiallytRNAi-Met; first identified as a negativeregulator of GCN4 expression &radic0.009630.2279&radic&radic&radic S000003213RTF1YGL244WverifiedSubunit of the RNA polymerase II-associated Paf1 complex;directly or indirectly regulates DNA-bindingproperties of Spt15p and relative activities ofdifferent TATA elements; involved in telomeremaintenance 0.009610.22698&radic&radic&radic&radic S000000831SMB1YER029CverifiedCore Sm protein Sm B; part of heteroheptameric complex (withSmd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm B and Sm B' 0.009570.22678&radic&radic S000002612COQ4YDR204WverifiedProtein with a role in ubiquinone (Coenzyme Q) biosynthesis,possibly functioning in stabilization of Coq7p;located on the matrix face of the mitochondrialinner membrane; component of a mitochondrialubiquinone-synthesizing complex 0.009540.22642&radic&radic&radic&radic S000005798YTM1YOR272WverifiedConstituent of 66S pre-ribosomal particles, required formaturation of the large ribosomal subunit 0.009530.22571&radic S000003189NIF3YGL221CverifiedProtein of unknown function, similar to Listeria monocytogenesmajor sigma factor (rpoD gene product); theauthentic, non-tagged protein is detected inhighly purified mitochondria in high-throughputstudies 0.009540.22571&radic&radic&radic&radic&radic&radic S000003303YGR071CUncharacterizedPutative protein of unknown function; deletion mutant has increased glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the nucleus 0.00950.22372&radic&radic&radic S000001696DOA1YKL213CverifiedWD repeat protein required for ubiquitin-mediated proteindegradation, forms complex with Cdc48p, plays arole in controlling cellular ubiquitinconcentration; also promotes efficient NHEJ inpostdiauxic/stationary phase 0.009390.22372&radic&radic&radic&radic&radic&radic S000005651CAT5YOR125CverifiedMitochondrial inner membrane protein directly involved inubiquinone biosynthesis, essential for severalother metabolic pathways including respirationand gluconeogenic gene activation 0.009420.22372&radic&radic&radic S000004975HHF2YNL030WverifiedOne of two identical histone H4 proteins (see also HHF1); corehistone required for chromatin assembly andchromosome function; contributes to telomericsilencing; N-terminal domain involved inmaintaining genomic integrity 0.009490.22372&radic S000003504YGR272CUncharacterizedPutative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 0.009350.22287&radic&radic&radic&radic&radic S000001312PCL7YIL050WverifiedPho85p cyclin of the Pho80p subfamily, forms a functionalkinase complex with Pho85p which phosphorylatesMmr1p and is regulated by Pho81p; involved inglycogen metabolism, expression is cell-cycleregulated 0.009340.22287&radic&radic&radic&radic&radic S000003188YGL220WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus 0.00930.22059&radic&radic&radic&radic&radic S000001051YHR009CUncharacterizedPutative protein of unknown function; not an essential gene 0.00930.22059&radic&radic&radic&radic&radic S000002549PEX7YDR142CverifiedPeroxisomal signal receptor for the N-terminal nonapeptidesignal (PTS2) of peroxisomal matrix proteins;WD repeat protein; defects in human homologcause lethal rhizomelic chondrodysplasiapunctata (RCDP) 0.00930.22059 S000000738UBC8YEL012WverifiedUbiquitin-conjugating enzyme that negatively regulatesgluconeogenesis by mediating theglucose-induced ubiquitination offructose-1,6-bisphosphatase (FBPase);cytoplasmic enzyme that catalyzes theubiquitination of histones in vitro 0.00920.22059&radic&radic&radic S000000231YBR027CDubiousHypothetical protein 0.009160.2201&radic&radic&radic S000000422PYC2YBR218CverifiedPyruvate carboxylase isoform, cytoplasmic enzyme that convertspyruvate to oxaloacetate; highly similar toisoform Pyc1p but differentially regulated;mutations in the human homolog are associatedwith lactic acidosis 0.009170.2201&radic&radic&radic&radic&radic S000003086YGL118CDubiousHypothetical protein 0.009120.21882&radic&radic&radic S000004421CRN1YLR429WverifiedCoronin, cortical actin cytoskeletal component that associateswith the Arp2p/Arp3p complex to regulate itsactivity 0.009130.21882 S000000230ETR1YBR026Cverified2-enoyl thioester reductase, member of the medium chaindehydrogenase/reductase family; localized to inmitochondria, where it has a probable role infatty acid synthesis 0.009090.21791&radic&radic&radic S000005316ABZ1YNR033WverifiedPara-aminobenzoate (PABA) synthase, has similarity toEscherichia coli PABA synthase components PabAand PabB 0.009080.21791&radic S000002838CYM1YDR430CverifiedLysine-specific metalloprotease of the mitochondrialintermembrane space, member of the pitrilysinfamily; degrades proteins and presequencepeptides cleaved from imported proteins;required for normal mitochondrial morphology 0.009070.21791&radic&radic&radic&radic&radic S000001780SIS2YKR072CverifiedNegative regulatory subunit of the protein phosphatase 1 Ppz1p;involved in ion homeostasis and cell cycleprogression 0.009040.2179&radic&radic&radic&radic S000003304UPF3YGR072WverifiedComponent of the nonsense-mediated mRNA decay (NMD) pathway,along with Nam7p and Nmd2p; involved in decayof mRNA containing nonsense codons; involved intelomere maintenance 0.009030.21633&radic&radic&radic&radic&radic&radic S000005147YNL203CDubiousHypothetical protein 0.0090.21633&radic&radic&radic&radic&radic&radic S000000294YBR090CUncharacterizedHypothetical protein 0.0090.21633&radic&radic&radic S000003105SEC27YGL137WverifiedEssential beta'-coat protein of the COPI coatomer, involved inER-to-Golgi and Golgi-to-ER transport; containsWD40 domains that mediate cargo selectiveinteractions; 45% sequence identity tomammalian beta'-COP 0.008980.21633&radic&radic&radic S000004361SSQ1YLR369WverifiedMitochondrial hsp70-type molecular chaperone, required forassembly of iron/sulfur clusters into proteinsat a step after cluster synthesis, and formaturation of Yfh1p, which is a homolog ofhuman frataxin implicated in Friedreich'sataxia 0.009010.21633&radic&radic&radic&radic&radic&radic S000000025YAL027WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YAL027W is a non-essential gene 0.0090.21633&radic&radic&radic&radic&radic&radic S000003959PRP19YLL036CverifiedSplicing factor associated with the spliceosome; contains aU-box, a motif found in a class of ubiquitinligases 0.0090.21633&radic&radic&radic&radic&radic&radic S000004190YKE2YLR200WverifiedSubunit of the heterohexameric Gim/prefoldin protein complexinvolved in the folding of alpha-tubulin,beta-tubulin, and actin 0.008960.21625&radic&radic&radic S000005784HNT3YOR258WverifiedMember of the third branch of the histidine triad (HIT)superfamily of nucleotide-binding proteins;similar to Aprataxin, a Hint related proteinthat is mutated in individuals with ataxia withoculomotor apraxia 0.008960.21625&radic&radic&radic&radic&radic&radic&radic&radic S000005662IDH2YOR136WverifiedSubunit of mitochondrial NAD(+)-dependent isocitratedehydrogenase, which catalyzes the oxidation ofisocitrate to alpha-ketoglutarate in the TCAcycle 0.008910.21434&radic&radic S000002487VPS41YDR080WverifiedVacuolar membrane protein that is a subunit of the homotypicvacuole fusion and vacuole protein sorting(HOPS) complex; essential for membrane dockingand fusion at the Golgi-to-endosome andendosome-to-vacuole stages of protein transport 0.008910.21434&radic&radic S000002761TRR1YDR353WverifiedCytoplasmic thioredoxin reductase, key regulatory enzyme thatdetermines the redox state of the thioredoxinsystem, which acts as a disulfide reductasesystem and protects cells against bothoxidative and reductive stress 0.008880.21434&radic&radic&radic&radic&radic&radic S000002656YDR248CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.008860.21371&radic&radic&radic&radic&radic&radic S000004760YIM1YMR152WverifiedProtein of unknown function; null mutant displays sensitivityto DNA damaging agents; the authentic,non-tagged protein is detected in highlypurified mitochondria in high-throughputstudies 0.008830.21371&radic&radic&radic&radic&radic S000000852RSM18YER050CverifiedMitochondrial ribosomal protein of the small subunit, hassimilarity to E. coli S18 ribosomal protein 0.008850.21371&radic&radic&radic S000004798HSC82YMR186WverifiedCytoplasmic chaperone of the Hsp90 family, redundant infunction and nearly identical with Hsp82p, andtogether they are essential; expressedconstitutively at 10-fold higher basal levelsthat HSP82 and induced 2-3 fold by heat shock 0.008830.21367&radic&radic&radic&radic S000002545HPR1YDR138WverifiedSubunit of THO/TREX complexes that couple transcriptionelongation with mitotic recombination and withmRNA metabolism and export, subunit of an RNAPol II complex; regulates lifespan; involved intelomere maintenance; similar to Top1p 0.00880.2129&radic&radic&radic&radic S000006400YPR196WUncharacterizednuclear protein (putative) 0.00880.2129&radic&radic&radic&radic&radic&radic S000004837MRE11YMR224CverifiedSubunit of a complex with Rad50p and Xrs2p (RMX complex) thatfunctions in repair of DNA double-strand breaksand in telomere stability, exhibits nucleaseactivity that appears to be required for RMXfunction; widely conserved 0.008780.21268&radic&radic&radic&radic&radic&radic S000001643ELF1YKL160WverifiedTranscription elongation factor that contains a conserved zincfinger domain; implicated in the maintenance ofproper chromatin structure in activelytranscribed regions; deletion inhibits Bromemosaic virus (BMV) gene expression 0.008760.21024&radic&radic&radic&radic&radic&radic S000000229YBR025CUncharacterizedHypothetical protein 0.008650.21024&radic&radic&radic&radic S000003367PRE9YGR135Wverified20S proteasome beta-type subunit; the only nonessential 20Ssubunit 0.008710.21024&radic&radic&radic&radic&radic S000001730NTR2YKR022CverifiedEssential protein that forms a dimer with Ntr1p; also forms atrimer, with Ntr2p and the DExD/H-box RNAhelicase Prp43p, that is involved inspliceosome disassembly 0.008730.21024&radic&radic&radic&radic&radic&radic&radic&radic S000001602VPH2YKL119CverifiedIntegral membrane protein required for vacuolar H+-ATPase(V-ATPase) function, although not an actualcomponent of the V-ATPase complex; functions inthe assembly of the V-ATPase; localized to theendoplasmic reticulum (ER) 0.008580.20873&radic&radic&radic S000000851TPA1YER049WuncharacterizedProtein of unknown function; interacts with Sup45p (eRF1),Sup35p (eRF3) and Pab1p; has a role intranslation termination efficiency, mRNApoly(A) tail length and mRNA stability 0.008560.20873&radic&radic&radic&radic S000005126IPI3YNL182CuncharacterizedProtein required for cell viability; computational analysis oflarge-scale protein-protein interaction datasuggests a possible role in assembly of theribosomal large subunit 0.008590.20873&radic&radic S000000382YBR178WDubiousHypothetical protein 0.008570.20873&radic&radic&radic&radic&radic S000005564HIR2YOR038CverifiedNon-essential transcriptional corepressor involved in the cellcycle-regulated transcription of histone H2A,H2B, H3, and H4 genes; recruits Swi-Snfcomplexes to histone gene promoters; promotesheterochromatic gene silencing with Asf1p 0.008580.20873&radic&radic&radic&radic S000003992NOC3YLR002CverifiedProtein that forms a nuclear complex with Noc2p that binds to66S ribosomal precursors to mediate theirintranuclear transport; also binds to chromatinto promote the association of DNA replicationfactors and replication initiation 0.00860.20873&radic&radic&radic&radic&radic&radic S000000853JHD1YER051WverifiedJmjC domain family histone demethylase specific for H3-K36,similar to proteins found in human, mouse,drosophila, X. laevis, C. elegans, and S. pombe 0.008590.20873&radic&radic&radic&radic S000001744CAF4YKR036CverifiedWD40 repeat-containing protein associated with the CCR4-NOTcomplex, interacts in a Ccr4p-dependent mannerwith Ssn2p; also interacts with Fis1p, Mdv1pand Dnm1p and plays a role in mitochondrialfission 0.008550.20827&radic&radic S000004973YNL028WDubiousHypothetical protein 0.008490.20686&radic&radic S000003337VMA21YGR105WverifiedIntegral membrane protein that is required for vacuolarH+-ATPase (V-ATPase) function, although not anactual component of the V-ATPase complex;functions in the assembly of the V-ATPase;localized to the yeast endoplasmic reticulum(ER) 0.008490.20686&radic&radic&radic&radic&radic S000003506TAF1YGR274CverifiedTFIID subunit (145 kDa), involved in RNA polymerase IItranscription initiation, has histoneacetyltransferase activity, involved inpromoter binding and G1/S progression 0.008410.20607&radic&radic&radic&radic&radic S000005823TIM18YOR297CverifiedComponent of the mitochondrial Tim54p-Tim22p complex involvedin insertion of polytopic proteins into theinner membrane; may function to stabilize thecomplex 0.008370.20493&radic&radic&radic&radic&radic&radic S000004410CDC73YLR418CverifiedConstituent of Paf1 complex with RNA polymerase II, Paf1p,Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinctfrom Srb-containing Pol II complexes; requiredfor expression of certain genes, modificationof some histones, and telomere maintenance 0.008380.20493&radic&radic&radic&radic&radic S000003957RIX7YLL034CverifiedPutative ATPase of the AAA family, required for export ofpre-ribosomal large subunits from the nucleus;distributed between the nucleolus, nucleoplasm,and nuclear periphery depending on growthconditions 0.008390.20493&radic&radic&radic&radic&radic&radic S000001897LOC1YFR001WverifiedNuclear protein involved in asymmetric localization of ASH1mRNA; binds double-stranded RNA in vitro;constituent of 66S pre-ribosomal particles 0.008350.20493&radic&radic&radic&radic S000001188YHR145CDubiousHypothetical protein 0.008330.20473&radic&radic S000003641SET4YJL105WverifiedProtein of unknown function, contains a SET domain 0.008330.20473 S000002774YDR366CUncharacterizedHypothetical protein 0.008290.20284 S000003334YGR102CUncharacterizedPutative protein of unknown function; transposon insertion mutant is salt sensitive, and the systematic deletion mutant has growth defects; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion 0.008210.20284&radic&radic&radic&radic&radic S000001917ATG18YFR021WverifiedPhosphatidylinositol 3,5-bisphosphate-binding protein of thevacuolar membrane, predicted to fold as aseven-bladed beta-propeller; required forrecycling of Atg9p through thepre-autophagosomal structure 0.008240.20284 S000006324CLB5YPR120CverifiedB-type cyclin involved in DNA replication during S phase;activates Cdc28p to promote initiation of DNAsynthesis; functions in formation of mitoticspindles along with Clb3p and Clb4p; mostabundant during late G1 phase 0.008240.20284&radic&radic S000004830GUA1YMR217WverifiedGMP synthase, an enzyme that catalyzes the second step in thebiosynthesis of GMP from inosine 5'-phosphate(IMP); transcription is not subject toregulation by guanine but is negativelyregulated by nutrient starvation 0.00820.20275&radic&radic S000003751YJL215CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data 0.008180.20226&radic&radic&radic S000004198SEC13YLR208WverifiedComponent of both the Nup84 nuclear pore sub-complex and of theCOPII complex (Sar1p, Sec13p, Sec16p, Sec23p,Sec24p, Sec31p, Sfb2p, and Sfb3p) which isimportant for the formation of ER to Golgitransport vesicles 0.008170.20192&radic&radic&radic&radic S000003605UTP18YJL069CuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.008170.20192 S000001028MUP3YHL036WverifiedLow affinity methionine permease, similar to Mup1p 0.008150.20061&radic&radic&radic&radic&radic S000005202DSL1YNL258CverifiedEndoplasmic reticulum (ER)-localized peripheral membraneprotein required for Golgi-to-ER retrogradetraffic; component of the ER target site thatinteracts with coatomer, the major component ofthe COPI vesicle protein coat 0.008120.20061&radic&radic&radic&radic&radic S000002218TSR1YDL060WverifiedProtein required for processing of 20S pre-rRNA in thecytoplasm, associates with pre-40S ribosomalparticles 0.008140.20061&radic&radic S000004233YLR243WUncharacterizedPutative protein of unknown function; YLR243W is an essential gene 0.008150.20061&radic&radic S000000935GLC7YER133WverifiedCatalytic subunit of type 1 serine/threonine proteinphosphatase, involved in many processesincluding glycogen metabolism, sporulation, andmitosis; interacts with multiple regulatorysubunits; predominantly isolated with Sds22p 0.008110.20061&radic&radic&radic S000005208PDR17YNL264CverifiedPhosphatidylinositol transfer protein (PITP), downregulatesPlb1p-mediated turnover of phosphatidylcholine,found in the cytosol and microsomes, homologousto Pdr16p, deletion affects phospholipidcomposition 0.0080.19915&radic&radic&radic&radic&radic S000004981NCE103YNL036WverifiedCarbonic anhydrase; poorly transcribed under aerobic conditionsand at an undetectable level under anaerobicconditions; involved in non-classical proteinexport pathway 0.008050.19915&radic&radic S000005837NOP58YOR310CverifiedProtein involved in pre-rRNA processing, 18S rRNA synthesis,and snoRNA synthesis; component of the smallsubunit processome complex, which is requiredfor processing of pre-18S rRNA 0.008040.19915&radic&radic&radic S000002930SPS2YDR522CverifiedProtein expressed during sporulation, redundant with Sps22p fororganization of the beta-glucan layer of thespore wall; S. pombe ortholog is a spore wallcomponent 0.008030.19915&radic&radic&radic S000002134FUN19YAL034CverifiedNon-essential protein of unknown function 0.0080.19915&radic&radic&radic&radic&radic S000001335SPO22YIL073CverifiedMeiosis-specific protein essential for chromosome synapsis,similar to phospholipase A2, involved incompletion of nuclear divisions during meiosis;induced early in meiosis 0.007960.19862&radic&radic&radic S000002772CDC40YDR364CverifiedPre-mRNA splicing factor, important for catalytic step II ofpre-mRNA splicing and plays a role in cellcycle progression; required for DNA synthesisduring mitosis and meiosis; has WD repeats 0.007950.19862&radic&radic&radic&radic&radic S000005563CYC2YOR037WverifiedMitochondrial peripheral inner membrane protein, contains a FADcofactor in a domain exposed in theintermembrane space; exhibits redox activity invitro; likely participates in ligation of hemeto acytochromes c and c1 (Cyc1p and Cyt1p) 0.007980.19862&radic&radic&radic&radic&radic&radic S000005384YOL024WUncharacterizedHypothetical protein 0.007940.198&radic&radic&radic S000001866CAF16YFL028CverifiedPart of the evolutionarily-conserved CCR4-NOT transcriptionalregulatory complex involved in controlling mRNAinitiation, elongation, and degradation;putative ABC ATPase; interacts with Ssn2p,Ssn3p, and Ssn8p 0.007930.198&radic&radic&radic&radic S000004460YPT7YML001WverifiedGTPase; GTP-binding protein of the rab family; required forhomotypic fusion event in vacuole inheritance,for endosome-endosome fusion, similar tomammalian Rab7 0.00790.1972&radic&radic&radic&radic S000001108SSF1YHR066WverifiedConstituent of 66S pre-ribosomal particles, required forribosomal large subunit maturation;functionally redundant with Ssf2p; member ofthe Brix family 0.007910.1972&radic&radic&radic&radic S000002284CDC48YDL126CverifiedATPase in ER, nuclear membrane and cytosol with homology tomammalian p97; in a complex with Npl4p andUfd1p participates in retrotranslocation ofubiquitinated proteins from the ER into thecytosol for degradation by the proteasome 0.00790.1972&radic&radic S000006132NIP7YPL211WverifiedNucleolar protein required for 60S ribosome subunit biogenesis,constituent of 66S pre-ribosomal particles;physically interacts with Nop8p and the exosomesubunit Rrp43p 0.007890.1972&radic&radic&radic&radic S000002435REG1YDR028CverifiedRegulatory subunit of type 1 protein phosphatase Glc7p,involved in negative regulation ofglucose-repressible genes 0.007850.197&radic&radic&radic S000005260PHA2YNL316CverifiedPrephenate dehydratase, catalyzes the conversion of prephanateto phenylpyruvate, which is a step in thephenylalanine biosynthesis pathway 0.007840.19683&radic&radic&radic S000001734GCN3YKR026CverifiedAlpha subunit of the translation initiation factor eIF2B, theguanine-nucleotide exchange factor for eIF2;activity subsequently regulated byphosphorylated eIF2; first identified as apositive regulator of GCN4 expression 0.007790.19606&radic&radic&radic&radic&radic&radic&radic S000004187SIK1YLR197WverifiedEssential evolutionarily-conserved nucleolar protein componentof the box C/D snoRNP complexes that direct2'-O-methylation of pre-rRNA during itsmaturation; overexpression causes spindleorientation defects 0.007790.19606&radic&radic&radic&radic S000003207CSE1YGL238WverifiedNuclear envelope protein that mediates the nuclear export ofimportin alpha (Srp1p), homolog of metazoan CASprotein, required for accurate chromosomesegregation 0.007820.19606&radic&radic&radic&radic&radic&radic&radic S000003954GPI13YLL031CverifiedER membrane localized phosphoryltransferase that addsphosphoethanolamine onto the third mannoseresidue of the glycosylphosphatidylinositol(GPI) anchor precursor; similar to human PIG-Oprotein 0.007820.19606&radic&radic&radic&radic&radic&radic S000003664PBS2YJL128CverifiedMAP kinase kinase that plays a pivotal role in the osmosensingsignal-transduction pathway, activated undersevere osmotic stress 0.007740.19466&radic&radic&radic S000005585YOR059CUncharacterizedHypothetical protein 0.007730.19466&radic&radic&radic&radic&radic S000001191IMP3YHR148WverifiedComponent of the SSU processome, which is required for pre-18SrRNA processing, essential protein thatinteracts with Mpp10p and mediates interactionsof Imp4p and Mpp10p with U3 snoRNA 0.007750.19466&radic&radic&radic S000000001TFC3YAL001CverifiedLargest of six subunits of the RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part of theTauB domain of TFIIIC that binds DNA at theBoxB promoter sites of tRNA and similar genes;cooperates with Tfc6p in DNA binding 0.007780.19466&radic&radic&radic&radic&radic&radic&radic&radic S000003323PRP31YGR091WverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.007720.19463&radic&radic&radic&radic&radic S000000451ENP1YBR247CverifiedProtein associated with U3 and U14 snoRNAs, required forpre-rRNA processing and 40S ribosomal subunitsynthesis; localized in the nucleus andconcentrated in the nucleolus 0.007710.19459&radic&radic&radic&radic S000001081MSC7YHR039CverifiedProtein of unknown function, green fluorescent protein(GFP)-fusion protein localizes to theendoplasmic reticulum; msc7 mutants aredefective in directing meiotic recombinationevents to homologous chromatids 0.007690.19428&radic&radic&radic&radic S000000796DSF1YEL070WuncharacterizedDeletion suppressor of mpt5 mutation 0.007640.19335 S000003510CWC22YGR278WverifiedEssential protein, component of a complex containing Cef1p, hassimilarity to S. pombe Cwf22p; putativespliceosomal component, based on computationalanalysis of large-scale protein-proteininteraction data 0.007620.19301&radic&radic&radic&radic&radic S000001501SWD2YKL018WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lys 4 and is involved intelomeric silencing; subunit of CPF (cleavageand polyadenylation factor), a complex involvedin RNAP II transcription termination &radic0.007610.19301&radic&radic&radic S000002665SET7YDR257CverifiedNuclear protein that contains a SET-domain, which have beenshown to mediate methyltransferase activity inother proteins 0.007610.19301&radic&radic&radic&radic&radic&radic S000001537DEF1YKL054CverifiedRNAPII degradation factor, forms a complex with Rad26p inchromatin, enables ubiquitination andproteolysis of RNAPII present in an elongationcomplex 0.007610.19301&radic&radic&radic S000002499UBC13YDR092WverifiedUbiquitin-conjugating enzyme involved in the error-free DNApostreplication repair pathway; interacts withMms2p to assemble ubiquitin chains at the UbLys-63 residue; DNA damage triggersredistribution from the cytoplasm to thenucleus 0.00760.19253&radic&radic&radic S000001906UBP6YFR010WverifiedUbiquitin-specific protease situated in the base subcomplex ofthe 26S proteasome, releases free ubiquitinfrom branched polyubiquitin chains; deletioncauses hypersensitivity to cycloheximide andother toxic compounds 0.007610.19253&radic&radic&radic&radic&radic S000005167ATG4YNL223WverifiedCysteine protease required for autophagy; cleaves Atg8p to aform required for autophagosome and Cvt vesiclegeneration; mediates attachment ofautophagosomes to microtubules throughinteractions with Tub1p and Tub2p 0.007560.19151&radic&radic&radic&radic&radic&radic S000003085YGL117WUncharacterizedPutative protein of unknown function 0.007560.19151&radic&radic&radic S000005370RCL1YOL010WverifiedRNA terminal phosphate cyclase-like protein involved in rRNAprocessing at sites A0, A1, and A2; does notpossess detectable RNA cyclase activity 0.007510.19111&radic&radic&radic S000005295URK1YNR012WverifiedUridine/cytidine kinase, component of the pyrimidineribonucleotide salvage pathway that convertsuridine into UMP and cytidine into CMP;involved in the pyrimidine deoxyribonucleotidesalvage pathway, converting deoxycytidine intodCMP 0.007510.19111&radic&radic&radic S000000200YBL104CUncharacterizedHypothetical protein 0.007470.19018&radic S000002848DOT1YDR440WverifiedNucleosomal histone H3-Lys79 methylase, associates withtranscriptionally active genes, functions ingene silencing at telomeres, most likely bydirectly modulating chromatin structure and Sirprotein localization &radic0.007430.19008&radic&radic S000000186MRP21YBL090WverifiedMitochondrial ribosomal protein of the large subunit; MRP21exhibits genetic interactions with mutations inthe COX2 and COX3 mRNA 5'-untranslated leadersequences 0.007430.19008&radic&radic&radic&radic&radic&radic S000003424TDH3YGR192CverifiedGlyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involvedin glycolysis and gluconeogenesis; tetramerthat catalyzes the reaction ofglyceraldehyde-3-phosphate to 1,3bis-phosphoglycerate; detected in the cytoplasmand cell-wall 0.00740.18924&radic&radic&radic&radic&radic S000002702DPL1YDR294CverifiedDihydrosphingosine phosphate lyase, regulates intracellularlevels of sphingolipid long-chain basephosphates (LCBPs), degrades phosphorylatedlong chain bases, prefers C16dihydrosphingosine-l-phosphate as a substrate 0.007430.18924&radic S000001220YHR177WUncharacterized 0.007420.18924&radic&radic&radic&radic&radic S000000173YBL077WDubiousHypothetical protein; open reading frame overlaps 3' end of essential ILS1 gene encoding cytoplasmic isoleucine-tRNA synthetase 0.007410.18924&radic&radic&radic&radic&radic S000002201PRP11YDL043CverifiedSubunit of the SF3a splicing factor complex, required forspliceosome assembly 0.007390.18924&radic&radic&radic&radic S000006090MEX67YPL169CverifiedPoly(A)RNA binding protein involved in nuclear mRNA export,component of the nuclear pore; ortholog ofhuman TAP 0.007430.18924&radic&radic S000003162HOS2YGL194CverifiedHistone deacetylase required for gene activation via specificdeacetylation of lysines in H3 and H4 histonetails; subunit of the Set3 complex, ameiotic-specific repressor of sporulationspecific genes that contains deacetylaseactivity 0.007390.18883&radic&radic&radic&radic&radic&radic&radic&radic S000002601YDR193WDubiousHypothetical protein 0.007390.18883&radic&radic&radic&radic&radic&radic&radic S000004925PSE1YMR308CverifiedKaryopherin/importin that interacts with the nuclear porecomplex; acts as the nuclear import receptorfor specific proteins, including Pdr1p, Yap1p,Ste12p, and Aft1p 0.007370.18883&radic&radic&radic S000004300IMH1YLR309CverifiedProtein involved in vesicular transport, mediates transportbetween an endosomal compartment and the Golgi,contains a Golgi-localization (GRIP) domainthat interacts with activated Arl1p-GTP tolocalize Imh1p to the Golgi 0.007360.18791&radic&radic&radic&radic&radic&radic S000001558YKL075CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin 0.007310.18734&radic&radic&radic&radic S000002157NHP6BYBR089C-AverifiedHigh-mobility group non-histone chromatin protein, functionallyredundant with Nhp6Ap; homologous to mammalianhigh mobility group proteins 1 and 2; acts torecruit transcription factor Rcs1p to certainpromoters 0.007310.18734&radic&radic S000002259DUN1YDL101CverifiedCell-cycle checkpoint serine-threonine kinase required for DNAdamage-induced transcription of certain targetgenes, phosphorylation of Rad55p and Sml1p, andtransient G2/M arrest after DNA damage; alsoregulates postreplicative DNA repair 0.007320.18734&radic&radic&radic&radic S000004732STO1YMR125WverifiedLarge subunit of the nuclear mRNA cap-binding protein complex,interacts with Npl3p to carry nuclear poly(A)+mRNA to cytoplasm; also involved in nuclearmRNA degradation and telomere maintenance;orthologous to mammalian CBP80 0.007310.18734&radic&radic&radic S000001561DHR2YKL078WverifiedPredominantly nucleolar DEAH-box RNA helicase, required for 18SrRNA synthesis 0.007260.18582&radic&radic&radic&radic&radic&radic S000001132YNG2YHR090CverifiedSubunit of the NuA4 histone acetyltransferase complex thatacetylates histone H4 and H2A; has similarityto the human tumor suppressor ING1 0.007240.18582&radic&radic S000000381EHT1YBR177CverifiedAcyl-coenzymeA:ethanol O-acyltransferase that plays a minorrole in medium-chain fatty acid ethyl esterbiosynthesis; contains esterase activity;localizes to lipid particles and themitochondrial outer membrane 0.007220.18524&radic&radic&radic&radic&radic S000000832CHZ1YER030WuncharacterizedPutative chaperone for Htz1p/H2A-H2B dimer 0.007210.18524&radic&radic&radic&radic S000002536SAC6YDR129CverifiedFimbrin, actin-bundling protein; cooperates with Scp1p(calponin/transgelin) in the organization andmaintenance of the actin cytoskeleton 0.007210.18524&radic&radic&radic&radic S000003212TAD1YGL243WverifiedtRNA-specific adenosine deaminase, deaminates adenosine-37 toinosine in tRNA-Ala 0.007150.18431&radic&radic&radic&radic&radic&radic S000003941DPS1YLL018CverifiedCytoplasmic aspartyl-tRNA synthetase, homodimeric enzyme thatcatalyzes the specific aspartylation oftRNA(Asp); class II aminoacyl tRNA synthetase;binding to its own mRNA may conferautoregulation 0.007170.18431&radic&radic&radic&radic&radic&radic S000000346MAK5YBR142WverifiedEssential nucleolar protein, putative DEAD-box RNA helicaserequired for maintenance of M1 dsRNA virus;involved in biogenesis of large (60S) ribosomalsubunits 0.007170.18431&radic&radic S000001341AIR1YIL079CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p to regulate methylationof Npl3p, which modulates Npl3p function inmRNA processing and export; has similarity toAir2p 0.007140.18431&radic&radic&radic S000002923SLF1YDR515WverifiedRNA binding protein that associates with polysomes; proposed tobe involved in regulating mRNA translation;involved in the copper-dependent mineralizationof copper sulfide complexes on cell surface incells cultured in copper salts 0.007180.18431&radic S000004011IRC25YLR021WuncharacterizedPutative protein of unknown function; mutant accumulatesunusually high amounts of dityrosine in thesoluble fraction though spores appearwild-type; YLR021W is not an essential gene;null mutant displays increased levels ofspontaneous Rad52 foci 0.007130.18406&radic&radic&radic&radic&radic&radic S000001314RPL34BYIL052CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl34Ap and has similarity to ratL34 ribosomal protein 0.007120.18406&radic&radic&radic S000002299RPO21YDL140CverifiedRNA polymerase II largest subunit B220, part of central core;phosphorylation of C-terminal heptapeptiderepeat domain regulates association withtranscription and splicing factors; similar tobacterial beta-prime 0.007140.18406&radic S000005356YNR073CUncharacterizedHypothetical protein 0.007130.18406&radic S000001924CDC14YFR028CverifiedProtein phosphatase required for mitotic exit; located in thenucleolus until liberated by the FEAR andMitotic Exit Network in anaphase, enabling itto act on key substrates to effect a decreasein CDK/B-cyclin activity and mitotic exit 0.007140.18406&radic&radic S000002740IRC3YDR332WuncharacterizedHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 0.007120.18319&radic&radic&radic&radic&radic&radic S000004416SPP382YLR424WverifiedEssential protein that forms a dimer with Ntr2p; also forms atrimer, with Ntr2p and Prp43p, that is involvedin spliceosome disassembly; found also in amultisubunit complex with the splicing factorClf1p; suppressor of prp38-1 mutation 0.007120.18319&radic&radic&radic&radic S000000123RPL19BYBL027WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl19Ap and has similarity to ratL19 ribosomal protein; rpl19a and rpl19b singlenull mutations result in slow growth, while thedouble null mutation is lethal 0.007110.18319&radic&radic&radic&radic&radic&radic S000005593ALG8YOR067CverifiedGlucosyl transferase, involved in N-linked glycosylation; addsglucose to the dolichol-linked oligosaccharideprecursor prior to transfer to protein duringlipid-linked oligosaccharide biosynthesis;similar to Alg6p 0.007110.18319&radic&radic&radic&radic S000001505CDC16YKL022CverifiedSubunit of the anaphase-promoting complex/cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition; required forsporulation 0.007090.18319&radic&radic&radic&radic&radic&radic&radic S000006330YPR126CDubiousHypothetical protein 0.007050.18253&radic&radic S000003482YGR250CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.007040.18225&radic&radic&radic S000001185RPC10YHR143W-AverifiedRNA polymerase subunit, found in RNA polymerase complexes I,II, and III 0.007030.18219&radic&radic&radic&radic&radic S000002198NAT1YDL040CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.007030.18219&radic&radic&radic S000002360TRM8YDL201WverifiedSubunit of a tRNA methyltransferase complex composed of Trm8pand Trm82p that catalyzes 7-methylguanosinemodification of tRNA &radic0.007030.18177&radic S000004072SRL2YLR082CverifiedProtein of unknown function; overexpression suppresses thelethality caused by a rad53 null mutation 0.007020.18177&radic&radic&radic&radic&radic&radic&radic&radic S000001190MRPL6YHR147CverifiedMitochondrial ribosomal protein of the large subunit 0.006970.18016&radic S000005403NTG2YOL043CverifiedDNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involvedin base excision repair, localizes to thenucleus 0.006970.18016&radic&radic S000006365SGV1YPR161CverifiedCyclin (Bur2p)-dependent protein kinase that functions intranscriptional regulation; phosphorylates thecarboxy-terminal domain of Rpo21p, which is thelargest subunit of RNA polymerase II; regulatedby Cak1p 0.007010.18016&radic&radic&radic S000000217YBR013CUncharacterizedHypothetical protein 0.007010.18016&radic&radic S000005462TPT1YOL102CverifiedtRNA 2'-phosphotransferase, catalyzes the final step in yeasttRNA splicing: the transfer of the 2'-PO(4)from the splice junction to NAD(+) to formADP-ribose 1''-2''cyclic phosphate andnicotinamide 0.006930.18016&radic&radic&radic S000002307NOP14YDL148CverifiedNucleolar protein, forms a complex with Noc4p that mediatesmaturation and nuclear export of 40S ribosomalsubunits; also present in the small subunitprocessome complex, which is required forprocessing of pre-18S rRNA 0.0070.18016 S000000112FUS3YBL016WverifiedMitogen-activated protein kinase involved in mating pheromoneresponse; activated by phosphorylation bySte7p; provides specificity during the matingvs. filamentous growth response byphosphorylating transcriptional and cytoplasmictargets 0.006920.1799&radic&radic&radic&radic&radic S000000402TAF5YBR198CverifiedSubunit (90 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification 0.006930.1799&radic&radic S000000934PMD1YER132CverifiedProtein with an N-terminal kelch-like domain, putative negativeregulator of early meiotic gene expression;required, with Mds3p, for growth under alkalineconditions 0.006920.17988&radic S000000564KRR1YCL059CverifiedEssential nucleolar protein required for the synthesis of 18SrRNA and for the assembly of 40S ribosomalsubunit 0.006920.17988&radic&radic&radic&radic&radic&radic&radic S000004117APC2YLR127CverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition; similar tocullin Cdc53p 0.006910.17959&radic&radic&radic&radic&radic&radic S000000083YAR047CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data 0.006910.17959&radic&radic&radic&radic S000004695YTA12YMR089CverifiedComponent, with Afg3p, of the mitochondrial inner membranem-AAA protease that mediates degradation ofmisfolded or unassembled proteins and is alsorequired for correct assembly of mitochondrialenzyme complexes 0.006830.17829 S000005820RRS1YOR294WverifiedEssential protein that binds ribosomal protein L11 and isrequired for nuclear export of the 60Spre-ribosomal subunit during ribosomebiogenesis; mouse homolog shows alteredexpression in Huntington's disease model mice 0.006870.17829&radic&radic&radic S000005450MSH2YOL090WverifiedProtein that forms heterodimers with Msh3p and Msh6p that bindto DNA mismatches to initiate the mismatchrepair process; contains a Walker ATP-bindingmotif required for repair activity; Msh2p-Msh6pbinds to and hydrolyzes ATP 0.006860.17829&radic&radic&radic&radic S000001146GRE3YHR104WverifiedAldose reductase involved in methylglyoxal, d-xylose andarabinose metabolism; stress induced (osmotic,ionic, oxidative, heat shock, starvation andheavy metals); regulated by the HOG pathway 0.006830.17829&radic&radic&radic&radic&radic&radic&radic&radic&radic S000004735ECM16YMR128WverifiedEssential DEAH-box ATP-dependent RNA helicase specific to theU3 snoRNP, predominantly nucleolar indistribution, required for 18S rRNA synthesis 0.006840.17829&radic&radic&radic S000003783LSM8YJR022WverifiedLsm (Like Sm) protein; forms heteroheptameric complex (withLsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p)that is part of spliceosomal U6 snRNP and isalso implicated in processing of pre-tRNA,pre-snoRNA, and pre-rRNA 0.006840.17829&radic&radic&radic&radic&radic S000001492MRT4YKL009WverifiedProtein involved in mRNA turnover and ribosome assembly,localizes to the nucleolus 0.006850.17829&radic&radic&radic&radic&radic S000002544RGP1YDR137WverifiedSubunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) thatcatalyzes nucleotide exchange on Ypt6p 0.006830.17816&radic&radic&radic&radic S000002203FAD1YDL045CverifiedFlavin adenine dinucleotide (FAD) synthetase, performs thesecond step in synthesis of FAD from riboflavin 0.006820.17791&radic&radic&radic&radic S000000245FAT1YBR041WverifiedFatty acid transporter and very long-chain fatty acyl-CoAsynthetase, may form a complex with Faa1p orFaa4p that imports and activates exogenousfatty acids 0.006820.17791&radic&radic S000001229KOG1YHR186CverifiedSubunit of TORC1, a rapamycin-sensitive complex involved ingrowth control that contains Tor1p or Tor2p,Lst8p and Tco89p; contains four HEAT repeatsand seven WD-40 repeats; may act as a scaffoldprotein to couple TOR and its effectors 0.006810.17733&radic&radic&radic&radic S000000099HTA2YBL003CverifiedOne of two nearly identical (see also HTA1) histone H2Asubtypes; core histone required for chromatinassembly and chromosome function; DNAdamage-dependent phosphorylation by Mec1pfacilitates DNA repair; acetylated by Nat4p 0.006810.17733&radic&radic&radic&radic&radic S000004753NDE1YMR145CverifiedMitochondrial external NADH dehydrogenase, catalyzes theoxidation of cytosolic NADH; Nde1p and Nde2pare involved in providing the cytosolic NADH tothe mitochondrial respiratory chain 0.006740.17639&radic&radic&radic S000003011DST1YGL043WverifiedGeneral transcription elongation factor TFIIS, enables RNApolymerase II to read through blocks toelongation by stimulating cleavage of nascenttranscripts stalled at transcription arrestsites 0.006740.17639&radic&radic&radic S000003530MRS11YHR005C-AverifiedEssential protein of the mitochondrial intermembrane space,forms a complex with Tim9p (TIM10 complex) thatmediates insertion of hydrophobic proteins atthe inner membrane, has homology to Mrs5p,which is also involved in this process 0.006720.17605&radic&radic&radic&radic S000006256NHP6AYPR052CverifiedHigh-mobility group non-histone chromatin protein, functionallyredundant with Nhp6Bp; homologous to mammalianhigh mobility group proteins 1 and 2; acts torecruit transcription factor Rcs1p to certainpromoters 0.006720.17578&radic&radic&radic S000002940YDR532CUncharacterizedProtein of unknown function that localizes to the nuclear side of the spindle pole body and along short spindles; deletion mutants have short telomeres; forms a complex with Spc105p 0.006710.17578&radic S000004625MSS1YMR023CverifiedMitochondrial protein, forms a heterodimer complex with Mto1pthat performs the 5-carboxymethylaminomethylmodification of the wobble uridine base inmitochondrial tRNAs; similar to human GTPBP3 0.006720.17578&radic&radic&radic&radic&radic S000001493UFD4YKL010CverifiedUbiquitin-protein ligase (E3) that interacts with Rpt4p andRpt6p, two subunits of the 19S particle of the26S proteasome; cytoplasmic E3 involved in thedegradation of ubiquitin fusion proteins 0.006710.17578&radic&radic&radic&radic&radic&radic&radic&radic S000005504NOP8YOL144WverifiedNucleolar protein required for 60S ribosomal subunit biogenesis 0.006690.1755&radic S000005312YNR029CUncharacterizedHypothetical protein 0.00670.1755&radic&radic&radic S000000149YBL053WDubiousHypothetical protein 0.006710.1755&radic&radic&radic&radic&radic S000006381YPR177CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex 0.00670.1755&radic&radic&radic&radic&radic&radic S000001359FYV10YIL097WverifiedProtein of unknown function, required for survival uponexposure to K1 killer toxin; involved inproteasome-dependent catabolite inactivation offructose-1,6-bisphosphatase; contains CTLHdomain 0.006690.1752&radic&radic&radic&radic&radic&radic&radic S000000221KAP104YBR017CverifiedTransportin, cytosolic karyopherin beta 2 involved in deliveryof heterogeneous nuclear ribonucleoproteins tothe nucleoplasm, binds rg-nuclear localizationsignals on Nab2p and Hrp1p, plays a role incell-cycle progression 0.006690.1752&radic&radic S000003100YGL132WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C 0.006680.1752&radic&radic&radic S000000459YBR255WUncharacterizedProtein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.006610.17302&radic&radic&radic S000005686MTR10YOR160WverifiedNuclear import receptor, mediates the nuclear localization ofproteins involved in mRNA-nucleus export 0.006580.17302&radic&radic&radic&radic&radic&radic&radic S000000846ERG28YER044CverifiedEndoplasmic reticulum membrane protein, may facilitateprotein-protein interactions between the Erg26pdehydrogenase and the Erg27p 3-ketoreductaseand/or tether these enzymes to the ER, alsointeracts with Erg6p 0.006650.17302&radic&radic&radic&radic S000001200REC104YHR157WverifiedProtein involved in early stages of meiotic recombination;required for meiotic crossing over; forms acomplex with Rec102p and Spo11p necessaryduring the initiation of recombination 0.006580.17302&radic S000002796RVS167YDR388WverifiedActin-associated protein, subunit of a complex(Rvs161p-Rvs167p) involved in regulation ofactin cytoskeleton, endocytosis, and viabilityfollowing starvation or osmotic stress; homologof mammalian amphiphysin 0.006580.17302&radic&radic&radic&radic S000002691GCN2YDR283CverifiedProtein kinase, phosphorylates the alpha-subunit of translationinitiation factor eIF2 (Sui2p) in response tostarvation; activated by uncharged tRNAs andthe Gcn1p-Gcn20p complex 0.006630.17302&radic&radic&radic S000002847LRS4YDR439WverifiedProtein involved in rDNA silencing; positively chargedcoiled-coil protein with limited similarity tomyosin 0.006650.17302&radic S000002578HSP42YDR171WverifiedSmall cytosolic stress-induced chaperone that formsbarrel-shaped oligomers and suppresses theaggregation of non-native proteins; oligomerdissociation is not required for function;involved in cytoskeleton reorganization afterheat shock 0.006660.17302&radic&radic&radic&radic S000000174ATG8YBL078CverifiedProtein required for autophagy; modified by the serial actionof Atg4p, Atg7p, and Atg3p, and conjugated atthe C terminus with phosphatidylethanolamine,to become the form essential for generation ofautophagosomes 0.006650.17302&radic&radic&radic&radic&radic S000005505CTR9YOL145CverifiedComponent of the Paf1p complex, which is a large complex thatbinds to and modulates the activity of RNApolymerase II and is required for expression ofa subset of genes, including cyclin genes;contains TPR repeats 0.006650.17302&radic&radic S000003038RPB9YGL070CverifiedRNA polymerase II subunit B12.6; contacts DNA; mutations affecttranscription start site; involved in telomeremaintenance 0.006550.17259&radic&radic&radic&radic&radic&radic S000006060UME1YPL139CverifiedNegative regulator of meiosis, required for repression of asubset of meiotic genes during vegetativegrowth, binding of histone deacetylase Rpd3prequired for activity, contains a NEE box and aWD repeat motif; homologous with Wtm1p, Wtm2p 0.006550.1724&radic&radic&radic&radic S000005405PSK2YOL045WverifiedOne of two (see also PSK1) PAS domain containing S/T proteinkinases; regulates sugar flux and translationin response to an unknown metabolite byphosphorylating Ugp1p and Gsy2p (sugar flux)and Caf20p, Tif11p and Sro9p (translation) 0.006550.1724&radic&radic&radic&radic S000005097GIM3YNL153CverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.006510.17149&radic&radic&radic&radic S000001464MND2YIR025WverifiedSubunit of the anaphase-promoting complex (APC); needed formeiotic nuclear division 0.006490.17149&radic&radic&radic&radic S000001215SPC97YHR172WverifiedComponent of the microtubule-nucleating Tub4p (gamma-tubulin)complex; interacts with Spc110p at the spindlepole body (SPB) inner plaque and with Spc72p atthe SPB outer plaque 0.006530.17149&radic&radic&radic&radic&radic S000002524TMA64YDR117CverifiedProtein of unknown function that associates with ribosomes; hasa putative RNA binding domain 0.00650.17149&radic&radic&radic&radic S000004170SAM1YLR180WverifiedS-adenosylmethionine synthetase, catalyzes transfer of theadenosyl group of ATP to the sulfur atom ofmethionine; one of two differentially regulatedisozymes (Sam1p and Sam2p) 0.006530.17149&radic&radic&radic&radic&radic S000005755WTM2YOR229WverifiedTranscriptional repressor involved in regulation of meiosis andsilencing; contains WD repeats 0.006460.17044&radic&radic S000002801SHE9YDR393WverifiedMitochondrial inner membrane protein required for normalmitochondrial morphology, may be involved infission of the inner membrane; forms ahomo-oligomeric complex 0.006440.17044&radic&radic&radic&radic&radic S000004272YLR282CDubiousHypothetical protein 0.006460.17044&radic&radic&radic&radic&radic&radic S000002351ARF1YDL192WverifiedADP-ribosylation factor, GTPase of the Ras superfamily involvedin regulation of coated formation vesicles inintracellular trafficking within the Golgi;functionally interchangeable with Arf2p 0.006470.17044&radic&radic&radic&radic S000002632HTB1YDR224CverifiedOne of two nearly identical (see HTB2) histone H2B subtypesrequired for chromatin assembly and chromosomefunction; Rad6p-Bre1p-Lge1p mediatedubiquitination regulates transcriptionalactivation, meiotic DSB formation and H3methylation 0.006450.17044&radic&radic&radic&radic&radic S000004096MDN1YLR106CverifiedHuge dynein-related AAA-type ATPase (midasin), forms extendedpre-60S particle with the Rix1 complex(Rix1p-Ipi1p-Ipi3p), may mediate ATP-dependentremodeling of 60S subunits and subsequentexport from nucleoplasm to cytoplasm 0.006490.17044&radic&radic&radic&radic S000001954MEI4YER044C-AverifiedMeiosis-specific protein involved in recombination; requiredfor chromosome synapsis; required forproduction of viable spores 0.006470.17044&radic&radic&radic&radic S000004040YLR050CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene 0.006440.17044&radic S000001049ERG11YHR007CverifiedLanosterol 14-alpha-demethylase, catalyzes the C-14demethylation of lanosterol to form4,4''-dimethylcholesta-8,14,24-triene-3-beta-ol in theergosterol biosynthesis pathway; member of thecytochrome P450 family 0.006470.17044&radic&radic&radic S000001334HOP1YIL072WverifiedMeiosis-specific DNA binding protein that displays Red1pdependent localization to the unsynapsedaxial-lateral elements of the synaptonemalcomplex; required for homologous chromosomesynapsis and chiasma formation 0.006440.1702&radic&radic&radic&radic&radic S000002625RAD9YDR217CverifiedDNA damage-dependent checkpoint protein, required forcell-cycle arrest in G1/S, intra-S, and G2/M;transmits checkpoint signal by activatingRad53p and Chk1p; hyperphosphorylated by Mec1pand Tel1p; potential Cdc28p substrate 0.006420.16989&radic&radic&radic&radic&radic S000005682NFI1YOR156CverifiedSUMO ligase, catalyzes the covalent attachment of SUMO (Smt3p)to proteins; involved in maintenance of propertelomere length 0.006410.16989&radic&radic&radic&radic&radic&radic&radic S000004046ERG3YLR056WverifiedC-5 sterol desaturase, catalyzes the introduction of a C-5(6)double bond into episterol, a precursor inergosterol biosynthesis; mutants are viable,but cannot grow on non-fermentable carbonsources 0.00640.16913&radic S000000046GEM1YAL048CverifiedEvolutionarily-conserved tail-anchored outer mitochondrialmembrane GTPase which regulates mitochondrialmorphology; cells lacking Gem1p containcollapsed, globular, or grape-likemitochondria; not required forpheromone-induced cell death 0.006410.16913&radic&radic&radic&radic&radic&radic&radic S000005649LEO1YOR123CverifiedComponent of the Paf1 complex, which associates with RNApolymerase II and is involved in histonemethylation 0.00640.16913&radic&radic&radic&radic&radic&radic S000000520BUD3YCL014WverifiedProtein involved in bud-site selection and required for axialbudding pattern; localizes with septins to budneck in mitosis and may constitute an axiallandmark for next round of budding 0.006380.16913&radic&radic&radic&radic S000002142PAU8YAL068CuncharacterizedHypothetical protein 0.006390.16913&radic&radic&radic&radic&radic S000006160YAR1YPL239WverifiedCytoplasmic ankyrin-repeat containing protein of unknownfunction, proposed to link the processes of 40Sribosomal subunit biogenesis and adaptation toosmotic and oxidative stress; expressionrepressed by heat shock 0.006360.16877&radic&radic&radic&radic&radic&radic S000000036CDC19YAL038WverifiedPyruvate kinase, functions as a homotetramer in glycolysis toconvert phosphoenolpyruvate to pyruvate, theinput for aerobic (TCA cycle) or anaerobic(glucose fermentation) respiration 0.006350.1685&radic&radic&radic&radic&radic&radic S000002311YDL152WDubiousHypothetical protein; open reading frame overlaps 5' end of essential SAS10 gene encoding a component of the small ribosomal subunit processosome 0.006350.1685&radic&radic&radic&radic S000000808NUG1YER006WverifiedGTPase that associates with nuclear 60S pre-ribosomes, requiredfor export of 60S ribosomal subunits from thenucleus 0.006350.1685&radic S000000022LTE1YAL024CverifiedPutative GDP/GTP exchange factor required for mitotic exit atlow temperatures; acts as a guanine nucleotideexchange factor (GEF) for Tem1p, which is a keyregulator of mitotic exit; physicallyassociates with Ras2p-GTP 0.006350.1685&radic&radic&radic S000005677RPB2YOR151CverifiedRNA polymerase II second largest subunit B150, part of centralcore; similar to bacterial beta subunit 0.006340.16823&radic&radic&radic&radic&radic S000002732UTP4YDR324CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.006330.16803&radic&radic&radic&radic&radic S000002200SIR2YDL042CverifiedConserved NAD+ dependent histone deacetylase of the Sirtuinfamily involved in regulation of lifespan;plays roles in silencing at HML, HMR,telomeres, and the rDNA locus; negativelyregulates initiation of DNA replication 0.006310.16798 S000002573SEC5YDR166CverifiedEssential 107kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which has the essential function ofmediating polarized targeting of secretoryvesicles to active sites of exocytosis 0.006320.16798&radic&radic&radic&radic&radic S000004494RAD52YML032CverifiedProtein that stimulates strand exchange by facilitating Rad51pbinding to single-stranded DNA; annealscomplementary single-stranded DNA; involved inthe repair of double-strand breaks in DNAduring vegetative growth and meiosis 0.006310.16738&radic&radic&radic&radic&radic&radic S000000745MMS21YEL019CverifiedSUMO ligase involved in chromosomal organization and DNArepair; essential subunit of theMms21-Smc5-Smc6 complex; mutants are sensitiveto methyl methanesulfonate and show increasedspontaneous mutation and mitotic recombination 0.006250.1666&radic&radic&radic&radic&radic&radic&radic S000002104RPL2AYFR031C-AverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl2Bp and has similarity to E.coli L2 and rat L8 ribosomal proteins 0.006260.1666&radic&radic&radic&radic S000002312SAS10YDL153CverifiedComponent of the small (ribosomal) subunit (SSU) processosomerequired for pre-18S rRNa processing; essentialnucleolar protein that, when overproduced,disrupts silencing 0.006250.1666&radic&radic&radic S000004274ECI1YLR284CverifiedPeroxisomal delta3,delta2-enoyl-CoA isomerase, hexamericprotein that converts 3-hexenoyl-CoA totrans-2-hexenoyl-CoA, essential for thebeta-oxidation of unsaturated fatty acids,oleate-induced 0.006280.1666&radic&radic&radic&radic&radic&radic S000002830SIP1YDR422CverifiedAlternate beta-subunit of the Snf1p kinase complex, may confersubstrate specificity; vacuolar proteincontaining KIS (Kinase-Interacting Sequence)and ASC (Association with Snf1 kinase Complex)domains involved in protein interactions 0.006240.16627&radic&radic S000001858RPO41YFL036WverifiedMitochondrial RNA polymerase; single subunit enzyme similar tothose of T3 and T7 bacteriophages; requires aspecificity subunit encoded by MTF1 forpromoter recognition 0.006250.16627&radic S000000303YBR099CDubiousHypothetical protein 0.006240.16627&radic&radic&radic S000005679PDR5YOR153WverifiedShort-lived membrane ABC (ATP-binding cassette) transporter,actively exports various drugs, expressionregulated by Pdr1p; also involved in steroidtransport, cation resistance, and cellulardetoxification during exponential growth 0.006220.16563&radic S000004665RNA14YMR061WverifiedCleavage and polyadenylation factor I (CF I) component involvedin cleavage and polyadenylation of mRNA 3'ends; bridges interaction between Rna15p andHrp1p in the CF I complex 0.006220.16563&radic&radic S000006345KAR3YPR141CverifiedMinus-end-directed microtubule motor that functions in mitosisand meiosis, localizes to the spindle pole bodyand localization is dependent on functionalCik1p, required for nuclear fusion duringmating; potential Cdc28p substrate 0.006220.16563&radic&radic&radic&radic&radic S000002773ESF1YDR365CverifiedNucleolar protein involved in pre-rRNA processing; depletioncauses severely decreased 18S rRNA levels 0.006220.16563&radic&radic&radic&radic S000001239UTP9YHR196WverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.00620.16563&radic&radic S000005711GSP2YOR185CverifiedGTP binding protein (mammalian Ranp homolog) involved in themaintenance of nuclear organization, RNAprocessing and transport; interacts withKap121p, Kap123p and Pdr6p (karyophilin betas);Gsp1p homolog that is not required forviability 0.006210.16563&radic&radic&radic&radic&radic S000000941YER139CUncharacterizedHypothetical protein 0.00620.16555&radic S000000749YEL023CUncharacterizedPutative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene 0.00620.16555&radic&radic&radic S000002789YRA1YDR381WverifiedNuclear protein that binds to RNA and to Mex67p, required forexport of poly(A)+ mRNA from the nucleus;member of the REF (RNA and export factorbinding proteins) family; another familymember, Yra2p, can substitute for Yra1pfunction 0.00620.16555&radic&radic&radic&radic&radic S000001133MSR1YHR091CverifiedMitochondrial arginyl-tRNA synthetase 0.006180.16491&radic&radic&radic S000003026RAD6YGL058WverifiedUbiquitin-conjugating enzyme (E2), involved in postreplicationrepair (with Rad18p), sporulation, telomeresilencing, and ubiquitin-mediated N-end ruleprotein degradation (with Ubr1p) 0.006180.16491&radic&radic&radic S000000458TRS20YBR254CverifiedOne of 10 subunits of the transport protein particle (TRAPP)complex of the cis-Golgi which mediates vesicledocking and fusion; mutations in the humanhomolog cause the spondyloepiphyseal dysplasiatarda (SEDL) disorder 0.006180.16491&radic&radic&radic&radic&radic S000000187MAP2YBL091CverifiedMethionine aminopeptidase, catalyzes the cotranslationalremoval of N-terminal methionine from nascentpolypeptides; function is partially redundantwith that of Map1p 0.006190.16491&radic&radic&radic&radic&radic&radic&radic S000002367NHP2YDL208WverifiedNuclear protein related to mammalian high mobility group (HMG)proteins, essential for function of H/ACA-typesnoRNPs, which are involved in 18S rRNAprocessing 0.00620.16491&radic S000000162SEF1YBL066CverifiedPutative transcription factor, has homolog in Kluyveromyceslactis 0.006180.16491&radic&radic&radic&radic&radic S000001283RPB3YIL021WverifiedRNA polymerase II third largest subunit B44, part of centralcore; similar to prokaryotic alpha subunit 0.006150.16432&radic&radic&radic&radic S000005795PAC1YOR269WverifiedProtein involved in nuclear migration, part of thedynein/dynactin pathway; targets dynein tomicrotubule tips, which is necessary forsliding of microtubules along bud cortex;synthetic lethal with bni1; homolog of humanLIS1 0.006170.16432&radic&radic S000002741YDR333CUncharacterizedHypothetical protein 0.006170.16432&radic&radic&radic&radic&radic&radic S000000169YBL073WDubiousHypothetical protein; open reading frame overlaps 5' end of essential AAR2 gene encoding a component of the U5 snRNP required for splicing of U3 precursors 0.006170.16432&radic&radic S000001518UGP1YKL035WverifiedUDP-glucose pyrophosphorylase (UGPase), catalyses thereversible formation of UDP-Glc from glucose1-phosphate and UTP, involved in a wide varietyof metabolic pathways, expression modulated byPho85p through Pho4p 0.006160.16432&radic&radic&radic&radic&radic S000003718YJL182CDubiousHypothetical protein 0.006150.16432&radic&radic&radic S000003209DOC1YGL240WverifiedProcessivity factor required for the ubiquitination activity ofthe anaphase promoting complex (APC), mediatesthe activity of the APC by contributing tosubstrate recognition; involved in cyclinproteolysis 0.006040.16123&radic&radic&radic&radic&radic&radic S000005377ESC8YOL017WverifiedProtein involved in telomeric and mating-type locus silencing,interacts with Sir2p and also interacts withthe Gal11p, which is a component of the RNA polII mediator complex 0.006050.16123&radic&radic&radic&radic&radic S000004069SIC1YLR079WverifiedInhibitor of Cdc28-Clb kinase complexes that controls G1/Sphase transition, preventing premature S phaseand ensuring genomic integrity; phosphorylationtargets Sic1p for SCF(CDC4)-dependent turnover;functional homolog of mammalian Kip1 0.006020.16123&radic&radic&radic S000003487COQ6YGR255CverifiedPutative flavin-dependent monooxygenase, involved in ubiquinone(Coenzyme Q) biosynthesis; located on thematrix side of the mitochondrial inner membrane 0.006130.16123&radic S000005475PAP2YOL115WverifiedCatalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), anuclear poly (A) polymerase complex involved inRNA quality control; catalyzes polyadenylationof unmodified tRNAs, and snoRNA and rRNAprecursors; disputed role as a DNA polymerase 0.006090.16123&radic&radic&radic S000005732NOC2YOR206WverifiedProtein that forms a nucleolar complex with Mak21p that bindsto 90S and 66S pre-ribosomes, as well as anuclear complex with Noc3p that binds to 66Spre-ribosomes; both complexes mediateintranuclear transport of ribosomal precursors 0.006030.16123&radic&radic&radic S000002806UTP5YDR398WverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.006060.16123&radic&radic&radic S000003398KRE11YGR166WverifiedProtein involved in biosynthesis of cell wall beta-glucans;subunit of the TRAPP (transport proteinparticle) complex, which is involved in thelate steps of endoplasmic reticulum to Golgitransport 0.006070.16123&radic&radic&radic&radic S000001930PHO4YFR034CverifiedBasic helix-loop-helix (bHLH) transcription factor; bindscooperatively with Pho2p to the PHO5 promoter;function is regulated by phosphorylation atmultiple sites and by phosphate availability 0.006020.16123&radic&radic&radic&radic&radic&radic S000005868RPA190YOR341WverifiedRNA polymerase I subunit; largest subunit of RNA polymerase I 0.006030.16123&radic&radic&radic S000003046DBP3YGL078CverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in ribosomal biogenesis 0.006120.16123&radic&radic&radic&radic S000002769BCP1YDR361CverifiedEssential protein involved in nuclear export of Mss4p, which isa lipid kinase that generatesphosphatidylinositol 4,5-biphosphate and playsa role in actin cytoskeleton organization andvesicular transport 0.006090.16123&radic&radic&radic&radic&radic S000002209LHP1YDL051WverifiedRNA binding protein required for maturation of tRNA and snRNAprecursors; acts as a molecular chaperone forRNAs transcribed by polymerase III; homologousto human La (SS-B) autoantigen 0.006060.16123&radic S000000101PDR3YBL005WverifiedTranscriptional activator of the pleiotropic drug resistancenetwork, regulates expression of ATP-bindingcassette (ABC) transporters through binding tocis-acting sites known as PDREs (PDR responsiveelements) 0.00610.16123&radic&radic&radic&radic&radic S000002839YDR431WDubiousHypothetical protein 0.006140.16123&radic&radic&radic S000002473YDR066CUncharacterizedHypothetical protein 0.006060.16123&radic&radic&radic&radic&radic&radic&radic S000005562PEP12YOR036WverifiedTarget membrane receptor (t-SNARE) for vesicular intermediatestraveling between the Golgi apparatus and thevacuole; controls entry of biosynthetic,endocytic, and retrograde traffic into theprevacuolar compartment; syntaxin 0.006050.16123&radic&radic&radic&radic&radic S000006322YPR118WVerifiedMethylthioribose-1-phosphate isomerase, catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway 0.006030.16123&radic&radic&radic&radic&radic S000005506PSF3YOL146WverifiedSubunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), whichis localized to DNA replication origins andimplicated in assembly of the DNA replicationmachinery 0.006040.16123&radic&radic S000000027MYO4YAL029CverifiedOne of two type V myosin motors (along with MYO2) involved inactin-based transport of cargos; required formRNA transport, including ASH1 mRNA, andfacilitating the growth and movement of ERtubules into the growing bud along with She3p 0.006050.16123&radic&radic&radic S000006347RRP15YPR143WverifiedNucleolar protein, constituent of pre-60S ribosomal particles;required for processing of the 27S pre-rRNA atthe A2 site to yield 5.8S and 25S rRNA 0.006080.16123&radic&radic&radic&radic S000004693YMR087WVerifiedPutative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain 0.006030.16123&radic&radic&radic S000003893NMD5YJR132WverifiedKaryopherin, a carrier protein involved in nuclear import ofproteins; importin beta homolog 0.006030.16123&radic&radic&radic&radic&radic S000003853FIP1YJR093CverifiedSubunit of cleavage polyadenylation factor (CPF), interactsdirectly with poly(A) polymerase (Pap1p) toregulate its activity 0.006050.16123&radic S000004339KAP95YLR347CverifiedKaryopherin beta, forms a dimeric complex with Srp1p (Kap60p)that mediates nuclear import of cargo proteinsvia a nuclear localization signal (NLS),interacts with nucleoporins to guide transportacross the nuclear pore complex 0.006050.16123&radic&radic&radic S000001030CBP2YHL038CverifiedMitochondrial protein required for splicing of the group Iintron aI5 of the COB pre-mRNA, binds to theRNA to promote splicing; also involved in butnot essential for splicing of the COB bI2intron and the intron in the 21S rRNA gene 0.006090.16123&radic&radic&radic&radic&radic S000004044OSW2YLR054CuncharacterizedProtein of unknown function proposed to be involved in theassembly of the spore wall 0.006010.16099&radic&radic&radic&radic S000001497URB1YKL014CverifiedNucleolar protein required for the normal accumulation of 25Sand 5.8S rRNAs, associated with the 27SA2pre-ribosomal particle; proposed to be involvedin the biogenesis of the 60S ribosomal subunit 0.0060.16031&radic&radic&radic S000003382YGR150CUncharacterizedPutative protein of unknown function; deletion mutant has growth defects on both non-fermentable carbon sources and rich medium; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; contains PPR motifs 0.005990.16031&radic&radic&radic&radic&radic S000003567MAD2YJL030WverifiedComponent of the spindle-assembly checkpoint complex, whichdelays the onset of anaphase in cells withdefects in mitotic spindle assembly; forms acomplex with Mad1p 0.005990.16031&radic&radic&radic S000004749YMR141CDubiousHypothetical protein 0.005980.16025&radic&radic&radic&radic&radic&radic S000005726YOR200WDubiousHypothetical protein 0.005970.15999&radic&radic&radic S000005605ATX2YOR079CverifiedGolgi membrane protein involved in manganese homeostasis;overproduction suppresses the sod1 (copper,zinc superoxide dismutase) null mutation 0.005970.15999&radic&radic&radic&radic&radic&radic S000003737ECM25YJL201WverifiedNon-essential protein of unknown function; promoter contains aconsensus binding sequence for factor Abf1p 0.005960.15958&radic&radic&radic S000005201SIP3YNL257CverifiedProtein that activates transcription through interaction withDNA-bound Snf1p, C-terminal region has aputative leucine zipper motif; potential Cdc28psubstrate 0.005960.15958&radic&radic&radic&radic&radic S000003645UTP10YJL109CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.005950.15958&radic&radic&radic S000001849SEC53YFL045CverifiedPhosphomannomutase, involved in synthesis of GDP-mannose anddolichol-phosphate-mannose; required forfolding and glycosylation of secretory proteinsin the ER lumen 0.005960.15958&radic&radic&radic&radic&radic&radic&radic S000001458MUC1YIR019CverifiedGPI-anchored cell surface glycoprotein required for diploidpseudohyphal formation and haploid invasivegrowth, transcriptionally regulated by the MAPKpathway (via Ste12p and Tec1p) and the cAMPpathway (via Flo8p) 0.005960.15958&radic&radic&radic S000004815ERG2YMR202WverifiedC-8 sterol isomerase, catalyzes the isomerization of thedelta-8 double bond to the delta-7 position atan intermediate step in ergosterol biosynthesis 0.005940.15814&radic&radic&radic S000003457AMA1YGR225WverifiedActivator of meiotic anaphase promoting complex (APC/C); Cdc20pfamily member; required for initiation of sporewall assembly; required for Clb1p degradationduring meiosis 0.005940.15814&radic&radic&radic&radic&radic&radic S000006404ARR2YPR200CverifiedArsenate reductase required for arsenate resistance; convertsarsenate to arsenite which can then be exportedfrom cells by Arr3p 0.005920.15814&radic&radic&radic&radic S000001547MNR2YKL064WverifiedPutative magnesium transporter; has similarity to Alr1p andAlr2p, which mediate influx of Mg2+ and otherdivalent cations 0.005940.15814&radic&radic&radic S000001224SVP26YHR181WverifiedIntegral membrane protein of the early Golgi apparatus andendoplasmic reticulum, involved in COP IIvesicle transport; may also function to promoteretention of proteins in the early Golgicompartment 0.005940.15814&radic&radic&radic S000003279TFC4YGR047CverifiedOne of six subunits of the RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part of theTauA domain of TFIIIC that binds BoxA DNApromoter sites of tRNA and similar genes; hasTPR motifs; human homolog is TFIIIC-102 0.005890.15796&radic&radic&radic&radic&radic S000002537FIN1YDR130CverifiedSpindle pole body-related intermediate filament protein, formscell cycle-specific filaments between spindlepole bodies in mother and daughter cells, ableto self-assemble, expression induced duringS/G2, localization cell-cycle dependent 0.005880.1576&radic&radic&radic&radic&radic&radic&radic&radic S000005357AIF1YNR074CverifiedMitochondrial cell death effector that translocates to thenucleus in response to apoptotic stimuli,homolog of mammalian Apoptosis-Inducing Factor,putative reductase 0.005880.1576 S000000041PTA1YAL043CverifiedSubunit of holo-CPF, a multiprotein complex and functionalhomolog of mammalian CPSF, required for thecleavage and polyadenylation of mRNA and snoRNA3' ends; involved in pre-tRNA processing; bindsto the phosphorylated CTD of RNAPII 0.005880.1576&radic&radic S000005654ADE2YOR128CverifiedPhosphoribosylaminoimidazole carboxylase, catalyzes a step inthe 'de novo' purine nucleotide biosyntheticpathway; red pigment accumulates in mutantcells deprived of adenine 0.005860.15708&radic&radic&radic&radic S000004249HSP60YLR259CverifiedTetradecameric mitochondrial chaperonin required forATP-dependent folding of precursor polypeptidesand complex assembly; prevents aggregation andmediates protein refolding after heat shock;role in mtDNA transmission; similarity to groEL 0.005870.15708&radic&radic&radic S000001055ARD1YHR013CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.005860.15708&radic&radic&radic S000000167YBL071CDubiousHypothetical protein 0.005840.15678&radic&radic&radic&radic S000005267LEM3YNL323WverifiedMembrane protein of the plasma membrane and ER, involved intranslocation of phospholipids andalkylphosphocholine drugs across the plasmamembrane 0.005840.15678&radic&radic&radic S000006393SKI3YPR189WverifiedProtein involved in exosome mediated 3' to 5' mRNA degradationand translation inhibition of non-poly(A)mRNAs; forms complex with Ski2p and Ski8p;required for repressing propagation of dsRNAviruses 0.005840.15669&radic&radic&radic&radic&radic&radic S000002716SRB7YDR308CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation; target of theglobal repressor Tup1p 0.005830.15669&radic&radic&radic&radic S000005378TLG2YOL018CverifiedSyntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1pand mediates fusion of endosome-derivedvesicles with the late Golgi; binds Vps45p,which prevents Tlg2p degradation and alsofacilitates t-SNARE complex formation 0.005830.15654&radic&radic&radic&radic S000001556LHS1YKL073WverifiedMolecular chaperone of the endoplasmic reticulum lumen,involved in polypeptide translocation andfolding; member of the Hsp70 family; localizesto the lumen of the ER; regulated by theunfolded protein response pathway 0.005830.15654&radic&radic S000002982PUF4YGL014WverifiedMember of the PUF protein family, which is defined by thepresence of Pumilio homology domains thatconfer RNA binding activity; preferentiallybinds mRNAs encoding nucleolar ribosomalRNA-processing factors 0.005820.15631&radic&radic&radic&radic S000005098YCK2YNL154CverifiedPalmitoylated, plasma membrane-bound casein kinase I isoform;shares redundant functions with Yck1p inmorphogenesis, proper septin assembly,endocytic trafficking; provides an essentialfunction overlapping with that of Yck1p 0.005810.15631&radic&radic&radic&radic&radic&radic S000000999STE20YHL007CverifiedSignal transducing kinase of the PAK (p21-activated kinase)family, involved in pheromone response andpseudohyphal/invasive growth pathways,activated by Cdc42p; binds Ste4p at a GBB motifpresent in noncatalytic domains of PAK kinases 0.005820.15631&radic&radic&radic&radic S000003702QCR8YJL166WverifiedSubunit 8 of ubiquinol cytochrome-c reductase complex, which isa component of the mitochondrial inner membraneelectron transport chain; oriented facing theintermembrane space; expression is regulated byAbf1p and Cpf1p 0.005810.15631&radic&radic&radic&radic&radic S000004211RSA3YLR221CverifiedProtein with a likely role in ribosomal maturation, requiredfor accumulation of wild-type levels of large(60S) ribosomal subunits; binds to the helicaseDbp6p in pre-60S ribosomal particles in thenucleolus 0.005820.15631&radic&radic&radic S000002467MAK21YDR060WverifiedConstituent of 66S pre-ribosomal particles, required for large(60S) ribosomal subunit biogenesis; involved innuclear export of pre-ribosomes; required formaintenance of dsRNA virus; homolog of humanCAATT-binding protein 0.005810.15631&radic S000002172NOP1YDL014WverifiedNucleolar protein, component of the small subunit processomecomplex, which is required for processing ofpre-18S rRNA; has similarity to mammalianfibrillarin &radic0.00580.15618 S000003715PFD1YJL179WverifiedSubunit of heterohexameric prefoldin, which binds cytosolicchaperonin and transfers target proteins to it;involved in the biogenesis of actin and ofalpha- and gamma-tubulin 0.005810.15618&radic&radic&radic&radic&radic&radic&radic&radic S000005415PSH1YOL054WuncharacterizedNuclear protein, putative RNA polymerase II elongation factor;isolated as Pob3p/Spt16p-binding protein 0.00580.15618&radic&radic&radic&radic&radic S000003700TPK1YJL164CverifiedSubunit of cytoplasmic cAMP-dependent protein kinase, whichcontains redundant catalytic subunits Tpk1p,Tpk2p, and Tpk3p and regulatory subunit Bcy1p;promotes vegetative growth in response tonutrients; inhibits filamentous growth 0.005810.15618&radic&radic&radic&radic&radic&radic&radic S000005252KRI1YNL308CverifiedEssential nucleolar protein required for 40S ribosomebiogenesis; physically and functionallyinteracts with Krr1p 0.005790.15567&radic&radic&radic S000000680TUP1YCR084CverifiedGeneral repressor of transcription, forms complex with Cyc8p,involved in the establishment of repressivechromatin structure through interactions withhistones H3 and H4, appears to enhanceexpression of some genes 0.00580.15567&radic S000002719TFB1YDR311WverifiedSubunit of TFIIH and nucleotide excision repair factor 3complexes, required for nucleotide excisionrepair, target for transcriptional activators 0.005790.15567&radic&radic S000001337RPN2YIL075CverifiedSubunit of the 26S proteasome, substrate of theN-acetyltransferase Nat1p 0.005740.15445&radic&radic&radic S000004368PSY3YLR376CuncharacterizedProtein of unknown function; deletion results in a mutatorphenotype suggesting a role for this protein asa mutational suppressor; deletion increasessensitivity to anticancer drugs oxaliplatin andcisplatin but not mitomycin C 0.005740.15445&radic&radic&radic&radic&radic&radic&radic S000004629YMR027WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene 0.005780.15445&radic&radic&radic&radic&radic S000005507PEX11YOL147CverifiedPeroxisomal membrane protein required for peroxisomeproliferation and medium-chain fatty acidoxidation, most abundant protein in theperoxisomal membrane, regulated by Adr1p andPip2p-Oaf1p, promoter contains ORE andUAS1-like elements 0.005760.15445&radic&radic S000006007ELP3YPL086CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;exhibits histone acetyltransferase activitythat is directed to histones H3 and H4;disruption confers resistance to K. lactiszymotoxin 0.005740.15445&radic&radic&radic&radic S000004778CEP3YMR168CverifiedEssential kinetochore protein, component of the CBF3 complexthat binds the CDEIII region of the centromere;contains an N-terminal Zn2Cys6 type zinc fingerdomain, a C-terminal acidic domain, and aputative coiled coil dimerization domain 0.005780.15445&radic S000003988YLL065WDubiousgrowth inhibitor 0.005760.15445&radic S000006119RPL7BYPL198WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl7Ap and has similarity to E.coli L30 and rat L7 ribosomal proteins;contains a conserved C-terminal Nucleic acidBinding Domain (NDB2) 0.005760.15445&radic&radic&radic S000000216YBR012CDubiousHypothetical protein 0.005740.15445&radic&radic S000000975RAD24YER173WverifiedCheckpoint protein, involved in the activation of the DNAdamage and meiotic pachytene checkpoints;subunit of a clamp loader that loadsRad17p-Mec3p-Ddc1p onto DNA; homolog of humanand S. pombe Rad17 protein 0.005750.15445&radic&radic&radic S000003272KSS1YGR040WverifiedMitogen-activated protein kinase (MAPK) involved in signaltransduction pathways that control filamentousgrowth and pheromone response 0.005750.15445&radic&radic&radic&radic S000003451YGR219WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C 0.005730.15421&radic&radic&radic&radic&radic&radic S000005582NOB1YOR056CverifiedEssential nuclear protein involved in proteasome maturation andsynthesis of 40S ribosomal subunits; requiredfor cleavage of the 20S pre-rRNA to generatethe mature 18S rRNA 0.005710.15383&radic&radic&radic S000006311YTH1YPR107CverifiedEssential RNA-binding component of cleavage and polyadenylationfactor, contains five zinc fingers; requiredfor pre-mRNA 3'-end processing andpolyadenylation 0.005720.15383&radic&radic&radic&radic&radic&radic S000002186MPS1YDL028CverifiedDual-specificity kinase required for spindle pole body (SPB)duplication and spindle checkpoint function;substrates include SPB proteins Spc42p,Spc110p, and Spc98p, mitotic exit networkprotein Mob1p, and checkpoint protein Mad1p 0.005710.15383&radic&radic&radic S000001611PMU1YKL128CverifiedPutative phosphomutase, contains a region homologous to theactive site of phsophomutases; overexpressionof the gene suppresses the histidine auxotrophyof an ade3 ade16 ade17 triple mutant and thetemperature sensitivity of a tps2 mutant 0.00570.15364&radic&radic&radic&radic&radic S000004901HSH155YMR288WverifiedU2-snRNP associated splicing factor that forms extensiveassociations with the branch site-3' splicesite-3' exon region upon prespliceosomeformation; similarity to the mammalian U2snRNP-associated splicing factor SAP155 0.005710.15364&radic&radic&radic&radic&radic&radic&radic&radic S000006130IPL1YPL209CverifiedAurora kinase involved in regulating kinetochore-microtubuleattachments; helps maintain condensedchromosomes during anaphase and earlytelophase; associates with Sli15p, whichpromotes Ipl1p association with mitotic spindle 0.00570.15334&radic&radic&radic&radic&radic&radic&radic S000001071YHI9YHR029CverifiedProtein of unknown function that is a member of the PhzFsuperfamily, although unlike its bacterialhomolog, is most likely not involved inphenazine production; possibly involved in amembrane regulation metabolic pathway 0.005690.15334&radic&radic S000001309SYG1YIL047CverifiedPlasma membrane protein of unknown function; truncation andoverexpression suppresses lethality of G-alphaprotein deficiency 0.005690.15334&radic&radic S000002315YDL156WUncharacterizedHypothetical protein 0.005670.1528&radic&radic&radic S000003716ATP12YJL180CverifiedConserved protein required for assembly of alpha and betasubunits into the F1 sector of mitochondrialF1F0 ATP synthase; mutation of human ATP12reduces active ATP synthase levels and isassociated with the disorder ATPAF2 deficiency 0.005690.1528&radic&radic&radic&radic&radic&radic S000000420YBP1YBR216CverifiedProtein required for oxidation of specific cysteine residues ofthe transcription factor Yap1p, resulting inthe nuclear localization of Yap1p in responseto stress 0.005680.1528&radic&radic&radic&radic&radic&radic&radic&radic S000001557MUD2YKL074CverifiedProtein involved in early pre-mRNA splicing; component of thepre-mRNA-U1 snRNP complex, the commitmentcomplex; interacts with Msl5p/BBP splicingfactor and Sub2p; similar to metazoan splicingfactor U2AF65 0.005690.1528&radic&radic&radic&radic&radic S000004911LCB1YMR296CverifiedComponent of serine palmitoyltransferase, responsible alongwith Lcb2p for the first committed step insphingolipid synthesis, which is thecondensation of serine with palmitoyl-CoA toform 3-ketosphinganine 0.005660.15272&radic&radic S000002461CDC34YDR054CverifiedUbiquitin-conjugating enzyme or E2; together with Skp1p, Rbx1p,Cdc53p, and an F-box protein, forms aubiquitin-protein ligase called the SCF complexwhich regulates cell cycle progression bytargeting key substrates for degradation 0.005620.15084&radic&radic&radic&radic S000002709CFT1YDR301WverifiedRNA-binding subunit of the mRNA cleavage and polyadenylationfactor; involved in poly(A) site recognitionand required for both pre-mRNA cleavage andpolyadenylation, 51% sequence similarity withmammalian AAUAA-binding subunit of CPSF 0.005650.15084&radic&radic S000007496IGO2YHR132W-AuncharacterizedPutative protein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to the cytoplasmand nucleus 0.005650.15084&radic&radic&radic&radic S000001107RRP3YHR065CverifiedProtein involved in rRNA processing; required for maturation ofthe 35S primary transcript of pre-rRNA and forcleavage leading to mature 18S rRNA; homologousto eIF-4a, which is a DEAD box RNA-dependentATPase with helicase activity 0.00560.15084&radic&radic&radic&radic S000005042RAS2YNL098CverifiedGTP-binding protein that regulates the nitrogen starvationresponse, sporulation, and filamentous growth;farnesylation and palmitoylation required foractivity and localization to plasma membrane;homolog of mammalian Ras proto-oncogenes 0.005650.15084&radic&radic S000003284FMP48YGR052WuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.005650.15084&radic&radic&radic&radic S000005926AEP3YPL005WverifiedPeripheral mitochondrial inner membrane protein, located on thematrix face of the membrane; stabilizes thebicistronic AAP1-ATP6 mRNA encoding subunits 6and 8 of the ATP synthase complex 0.005660.15084&radic&radic&radic&radic&radic S000002869MFA1YDR461WverifiedMating pheromone a-factor, made by a cells; interacts withalpha cells to induce cell cycle arrest andother responses leading to mating; biogenesisinvolves C-terminal modification, N-terminalproteolysis, and export; also encoded by MFA2 0.005640.15084&radic&radic&radic S000000358RPB5YBR154CverifiedRNA polymerase subunit ABC27, common to RNA polymerases I, II,and III; contacts DNA and affectstransactivation 0.005640.15084&radic&radic&radic S000002304COP1YDL145CverifiedAlpha subunit of COPI vesicle coatomer complex, which surroundstransport vesicles in the early secretorypathway 0.005620.15084 S000005402NGL1YOL042WverifiedPutative endonuclease, has a domain similar to amagnesium-dependent endonuclease motif in mRNAdeadenylase Ccr4p; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.005660.15084&radic&radic S000001562SMY1YKL079WverifiedProtein that interacts with Myo2p, proposed to be involved inexocytosis; N-terminal domain is related to themotor domain of kinesins 0.005620.15084&radic&radic&radic&radic&radic&radic S000003388PTI1YGR156WverifiedPta1p Interacting protein 0.005590.15009&radic&radic&radic S000000341YBR137WUncharacterizedProtein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); YBR137W is not an essential gene 0.005570.15009&radic&radic S000003993YLR003CUncharacterizedPutative protein of unknown function that may participate in DNA replication; green fluorescent protein (GFP)-fusion protein is localized to the nucleus; YLR003C is not an essential gene 0.005590.15009&radic&radic&radic&radic&radic&radic&radic S000002893VPS72YDR485CverifiedHtz1p-binding component of the SWR1 complex, which exchangeshistone variant H2AZ (Htz1p) forchromatin-bound histone H2A; required forvacuolar protein sorting 0.005570.15009&radic S000003136HUR1YGL168WuncharacterizedProtein required for hydroxyurea resistance; has possible rolesin DNA replication and maintenance of propertelomere length 0.005570.15009&radic&radic&radic S000000435SWC5YBR231CuncharacterizedProtein of unknown function, component of the SWR1 complex,which exchanges histone variant H2AZ (Htz1p)for chromatin-bound histone H2A 0.005570.15009&radic&radic&radic&radic S000004631FAR8YMR029CverifiedProtein involved in G1 cell cycle arrest in response topheromone, in a pathway different from theFar1p-dependent pathway; interacts with Far3p,Far7p, Far9p, Far10p, and Far11p 0.005580.15009&radic&radic&radic&radic&radic S000002527TRM1YDR120CverifiedtRNA methyltransferase, localizes to both the nucleus andmitochondrion to produce the modified baseN2,N2-dimethylguanosine in tRNAs in bothcompartments &radic0.005570.14999&radic&radic&radic&radic&radic S000004698AIP1YMR092CverifiedActin cortical patch component, interacts with the actindepolymerizing factor cofilin; required torestrict cofilin localization to corticalpatches; contains WD repeats 0.005560.1499 S000003796RAD26YJR035WverifiedProtein involved in transcription-coupled repair nucleotideexcision repair of UV-induced DNA lesions;homolog of human CSB protein 0.005540.14922&radic&radic&radic S000005964NOP4YPL043WverifiedNucleolar protein, essential for processing and maturation of27S pre-rRNA and large ribosomal subunitbiogenesis; constituent of 66S pre-ribosomalparticles; contains four RNA recognition motifs(RRMs) 0.005530.14922&radic&radic S000004140STM1YLR150WverifiedProtein that binds G4 quadruplex and purine motif triplexnucleic acid; acts with Cdc13p to maintaintelomere structure; interacts with ribosomesand subtelomeric Y' DNA; multicopy suppressorof tom1 and pop2 mutations 0.005520.1479&radic&radic S000002534ARO1YDR127WverifiedPentafunctional arom protein, catalyzes steps 2 through 6 inthe biosynthesis of chorismate, which is aprecursor to aromatic amino acids 0.00550.1479&radic&radic&radic&radic&radic S000005830YOR304C-AUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck 0.005480.1479&radic&radic&radic&radic S000004437YLR445WUncharacterizedHypothetical protein 0.005520.1479&radic&radic S000002800SPT3YDR392WverifiedSubunit of the SAGA and SAGA-like transcriptional regulatorycomplexes, interacts with Spt15p to activatetranscription of some RNA polymeraseII-dependent genes, also functions to inhibittranscription at some promoters 0.00550.1479&radic&radic&radic&radic S000001414YIL152WUncharacterizedHypothetical protein 0.005480.1479 S000000070ADE1YAR015WverifiedN-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR)synthetase, required for 'de novo' purinenucleotide biosynthesis; red pigmentaccumulates in mutant cells deprived of adenine 0.005490.1479&radic&radic&radic&radic&radic&radic&radic&radic&radic S000002794MUS81YDR386WverifiedHelix-hairpin-helix protein, involved in DNA repair andreplication fork stability; functions as anendonuclease in complex with Mms4p; interactswith Rad54p 0.005480.1479&radic&radic S000002765YDR357CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.005520.1479&radic&radic&radic&radic&radic&radic S000004232ARV1YLR242CverifiedProtein required for normal intracellular sterol distributionand for sphingolipid metabolism; similar toNup120p and C. elegans R05H5.5 protein 0.005480.1479&radic&radic&radic&radic&radic&radic S000000013NTG1YAL015CverifiedDNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involvedin base excision repair, localizes to thenucleus and mitochondrion 0.00550.1479&radic&radic&radic&radic&radic&radic&radic&radic&radic S000000158YBL062WDubiousHypothetical protein 0.005510.1479&radic&radic&radic&radic&radic S000006257YPR053CDubiousHypothetical protein 0.005520.1479&radic&radic S000001894SPB4YFL002CverifiedPutative ATP-dependent RNA helicase, nucleolar protein requiredfor synthesis of 60S ribosomal subunits at alate step in the pathway; sediments with 66Spre-ribosomes in sucrose gradients 0.005480.14787&radic&radic S000004239YEF3YLR249WverifiedTranslational elongation factor, stimulates the binding ofaminoacyl-tRNA (AA-tRNA) to ribosomes byreleasing EF-1 alpha from the ribosomalcomplex; contains two ABC cassettes; binds andhydrolyses ATP 0.005460.14757&radic&radic&radic S000003439YGR207CVerifiedProtein of unknown function; homolog of mammalian electron transfer flavoprotein complex subunit ETF-beta; interacts with frataxin (Yfh1p) 0.005420.14592&radic&radic&radic&radic&radic&radic S000001789RPF2YKR081CverifiedEssential protein involved in the processing of pre-rRNA andthe assembly of the 60S ribosomal subunit;interacts with ribosomal protein L11; localizespredominantly to the nucleolus; constituent of66S pre-ribosomal particles 0.005450.14592&radic&radic&radic S000000106YBL010CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles 0.005430.14592&radic&radic&radic&radic S000003271YGR039WDubiousHypothetical protein 0.005410.14592&radic&radic&radic&radic&radic&radic S000006014NOG1YPL093WverifiedPutative GTPase that associates with free 60S ribosomalsubunits in the nucleolus and is required for60S ribosomal subunit biogenesis; constituentof 66S pre-ribosomal particles; member of theODN family of nucleolar G-proteins 0.005430.14592&radic&radic&radic S000000069BUD14YAR014CverifiedProtein involved in bud-site selection, Bud14p-Glc7p complexfunctions as a cortical regulator of dynein;diploid mutants display a random buddingpattern instead of the wild-type bipolarpattern 0.00540.14592&radic&radic&radic&radic&radic&radic&radic&radic S000003782REC107YJR021CverifiedProtein involved in early stages of meiotic recombination;involved in altering chromatin structure at DNAdouble-stranded break sites and in coordinationbetween the initiation of recombination and thefirst division of meiosis 0.005430.14592&radic&radic&radic S000004039YLR049CUncharacterizedHypothetical protein 0.005460.14592&radic&radic&radic S000002232BRE1YDL074CverifiedE3 ubiquitin ligase for Rad6p, required for the ubiquitinationof histone H2B, recruitment of Rad6p topromoter chromatin and subsequent methylationof histone H3 (on L4 and L79), contains RINGfinger domain 0.005430.14592&radic&radic&radic S000005530UTP23YOR004WverifiedEssential nucleolar protein that is a component of the SSU(small subunit) processome involved in 40Sribosomal subunit biogenesis; has homology toPINc domain protein Fcf1p, although the PINcdomain of Utp23p is not required for function 0.005450.14592&radic&radic&radic S000001597APN1YKL114CverifiedMajor apurinic/apyrimidinic endonuclease, 3'-repair diesteraseinvolved in repair of DNA damage by oxidationand alkylating agents; also functions as a3'-5' exonuclease to repair7,8-dihydro-8-oxodeoxyguanosine 0.005460.14592&radic&radic&radic&radic&radic&radic S000005070SPC98YNL126WverifiedComponent of the microtubule-nucleating Tub4p (gamma-tubulin)complex; interacts with Spc110p at the spindlepole body (SPB) inner plaque and with Spc72p atthe SPB outer plaque 0.005430.14592&radic S000000540GRX1YCL035CverifiedHydroperoxide and superoxide-radical responsive heat-stableglutathione-dependent disulfide oxidoreductasewith active site cysteine pair; protects cellsfrom oxidative damage 0.005450.14592&radic&radic&radic&radic&radic S000002323CDC9YDL164CverifiedDNA ligase found in the nucleus and mitochondria, an essentialenzyme that joins Okazaki fragments during DNAreplication; also acts in nucleotide excisionrepair, base excision repair, and recombination 0.005430.14592&radic&radic S000000209RCR1YBR005WverifiedProtein of the endoplasmic reticulum membrane involved inchitin deposition in the cell wall;overproduction confers resistance to Congo Red 0.00540.14592&radic&radic&radic S000000824SRB4YER022WverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation 0.00540.14592&radic&radic&radic&radic&radic&radic&radic&radic S000003946YLL023CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLL023C is not an essential gene 0.005450.14592&radic&radic&radic S000002837TIF35YDR429CverifiedSubunit of the core complex of translation initiation factor3(eIF3), which is essential for translation 0.005450.14592&radic&radic&radic&radic S000000214HHT1YBR010WverifiedOne of two identical histone H3 proteins (see also HHT2); corehistone required for chromatin assembly,involved in heterochromatin-mediated telomericand HM silencing; regulated by acetylation,methylation, and mitotic phosphorylation 0.005410.14592&radic S000002688RRP45YDR280WverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex 0.005450.14592&radic&radic&radic S000003416UBR1YGR184CverifiedUbiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2pto ubiquitinate substrates of the N-end rulepathway; binds to the Rpn2p, Rpt1p, and Rpt6pproteins of the 19S particle of the 26Sproteasome 0.00540.14568&radic S000005735NPT1YOR209CverifiedNicotinate phosphoribosyltransferase, acts in the salvagepathway of NAD+ biosynthesis; required forsilencing at rDNA and telomeres and has a rolein silencing at mating-type loci; localized tothe nucleus 0.00540.14568&radic&radic&radic&radic&radic&radic S000000886YER084WDubiousHypothetical protein 0.005390.14568&radic&radic&radic&radic&radic&radic S000002909PLM2YDR501WverifiedProtein required for partitioning of the 2-micron plasmid 0.005370.14519&radic S000000829GAL83YER027CverifiedOne of three possible beta-subunits of the Snf1 kinase complex,allows nuclear localization of the Snf1 kinasecomplex in the presence of a nonfermentablecarbon source; contains glycogen-binding domain 0.005370.14519&radic&radic&radic&radic S000004560RAD10YML095CverifiedSingle-stranded DNA endonuclease (with Rad1p), cleavessingle-stranded DNA during nucleotide excisionrepair and double-strand break repair; subunitof Nucleotide Excision Repair Factor 1 (NEF1);homolog of human ERCC1 protein 0.005370.14519&radic&radic&radic&radic&radic S000005873REV1YOR346WverifiedDeoxycytidyl transferase, forms a complex with the subunits ofDNA polymerase zeta, Rev3p and Rev7p; involvedin repair of abasic sites in damaged DNA 0.005370.14519&radic&radic&radic&radic S000004075ARP6YLR085CverifiedActin-related protein that binds nucleosomes; a component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.005390.14519&radic&radic&radic S000005204YNL260CUncharacterizedPutative protein of unknown function with similarity to a human protein overexpressed in oral cancers; localizes to the nucleus and cytoplasm; YNL260C is an essential gene 0.005370.14519&radic&radic&radic S000003214GUS1YGL245WverifiedGlutamyl-tRNA synthetase (GluRS), forms a complex withmethionyl-tRNA synthetase (Mes1p) and Arc1p;complex formation increases the catalyticefficiency of both tRNA synthetases and ensurestheir correct localization to the cytoplasm 0.005380.14519&radic&radic&radic&radic&radic&radic S000002256SNU23YDL098CverifiedComponent of U4/U6.U5 snRNP involved in mRNA splicing viaspliceosome 0.005350.14468&radic&radic&radic S000003648MDV1YJL112WverifiedPeripheral protein of the cytosolic face of the mitochondrialouter membrane, required for mitochondrialfission; interacts with Fis1p and with thedynamin-related GTPase Dnm1p; contains WDrepeats 0.005370.14468 S000000412DUR1,2YBR208CverifiedUrea amidolyase, contains both urea carboxylase and allophanatehydrolase activities, degrades urea to CO2 andNH3; expression sensitive to nitrogencatabolite repression and induced byallophanate, an intermediate in allantoindegradation 0.005350.14468&radic&radic&radic&radic S000006021ATG21YPL100WverifiedPhosphatidylinositol 3,5-bisphosphate-binding protein requiredfor maturation of pro-aminopeptidase I,predicted to fold as a seven-bladedbeta-propeller; displays punctate cytoplasmiclocalization 0.005360.14468&radic S000002546RUB1YDR139CverifiedUbiquitin-like protein with similarity to mammalian NEDD8;conjugation (neddylation) substrates includethe cullins Cdc53p, Rtt101p, and Cul3p;activated by Ula1p and Uba3p (E1 enzyme pair);conjugation mediated by Ubc12p (E2 enzyme) 0.005370.14468&radic&radic&radic&radic&radic S000003142BUD13YGL174WverifiedSubunit of the RES complex, which is required for nuclearpre-mRNA retention and splicing; involved inbud-site selection; diploid mutants display aunipolar budding pattern instead of thewild-type bipolar pattern 0.005340.14409&radic&radic&radic&radic&radic S000005205ORC5YNL261WverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing 0.005330.14409&radic&radic&radic&radic S000005119NOP13YNL175CverifiedProtein of unknown function, localizes to the nucleolus andnucleoplasm; contains an RNA recognition motif(RRM) and has similarity to Nop12p, which isrequired for processing of pre-18S rRNA 0.005330.14409&radic&radic&radic S000001869BST1YFL025CverifiedGPI inositol deacylase of the ER that negatively regulatesCOPII vesicle formation, prevents production ofvesicles with defective subunits, required forproper discrimination between resident ERproteins and Golgi-bound cargo molecules 0.005340.14409&radic S000004956YNL011CUncharacterizedPutative protein of unknown function; YNL011C is not an essential gene 0.005330.14409&radic S000003093MET13YGL125WverifiedIsozyme of methylenetetrahydrofolate reductase, catalyzes thereduction of 5,10-methylenetetrahydrofolate to5-methyltetrahydrofolate in the methioninebiosynthesis pathway 0.005340.14409&radic&radic&radic&radic&radic S000000964RAD4YER162CverifiedProtein that recognizes and binds damaged DNA (with Rad23p)during nucleotide excision repair; subunit ofNuclear Excision Repair Factor 2 (NEF2);homolog of human XPC protein 0.005330.14409&radic&radic&radic S000005511GRE2YOL151WverifiedNADPH-dependent methylglyoxal reductase (D-lactaldehydedehydrogenase); stress induced (osmotic, ionic,oxidative, heat shock and heavy metals);regulated by the HOG pathway 0.00530.14322&radic&radic&radic S000005531DNL4YOR005CverifiedDNA ligase required for nonhomologous end-joining (NHEJ), formsstable heterodimer with required cofactorLif1p, catalyzes DNA ligation as part of acomplex with Lif1p and Nej1p; involved inmeiosis, not essential for vegetative growth 0.005310.14322&radic&radic&radic S000003484GCN5YGR252WverifiedHistone acetyltransferase, acetylates N-terminal lysines onhistones H2B and H3; catalytic subunit of theADA and SAGA histone acetyltransferasecomplexes; founding member of the Gcn5p-relatedN-acetyltransferase superfamily 0.005310.14322&radic