Yfunc lets you browse current and predicted gene functions in yeast

Enter a GO term ID (example: GO:0003723):
Enter a yeast gene name to browse (example:AIR1):

Prediction of GO:0016772 "transferase activity, transferring phosphorus-containing groups"

GO branch: MF
Number of currently annotated genes: 290

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest Kumar:cyto.Lum:HaloperidolHuh:cytoplasmHuh:nucleusHuh:mitochondrionIPR011009PS00627Lum:OmeprazoleLum:NaproxenLum:Doxorubicin S000001609YPK1YKL126WverifiedSerine/threonine protein kinase required for receptor-mediatedendocytosis; involved in sphingolipid-mediatedand cell integrity signaling pathways;localized to the bud neck, cytosol and plasmamembrane; homolog of mammalian kinase SGK &radic0.895521&radic&radic&radic&radic&radic S000004238RCK2YLR248WverifiedProtein kinase involved in the response to oxidative andosmotic stress; identified as suppressor of S.pombe cell cycle checkpoint mutations &radic0.896041&radic&radic&radic&radic&radic S000003631BCK1YJL095WverifiedMitogen-activated protein (MAP) kinase kinase kinase acting inthe protein kinase C signaling pathway, whichcontrols cell integrity; upon activation byPkc1p phosphorylates downstream kinases Mkk1pand Mkk2p &radic0.92191&radic&radic S000001584HSL1YKL101WverifiedNim1p-related protein kinase that regulates the morphogenesisand septin checkpoints; associates with theassembled septin filament; required along withHsl7p for bud neck recruitment,phosphorylation, and degradation of Swe1p &radic0.909071&radic&radic&radic&radic S000005587CKA2YOR061WverifiedAlpha' catalytic subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKB1 and CKB2, the many substratesinclude transcription factors and all RNApolymerases &radic0.879891&radic&radic&radic&radic&radic&radic S000004747RIM11YMR139WverifiedProtein kinase required for signal transduction during entryinto meiosis; promotes the formation of theIme1p-Ume6p complex by phosphorylating Ime1pand Ume6p; shares similarity with mammalianglycogen synthase kinase 3-beta &radic0.900851&radic&radic&radic S000004603CDC5YMR001CverifiedPolo-like kinase with similarity to Xenopus Plx1 and S. pombePlo1p; found at bud neck, nucleus and SPBs; hasmultiple functions in mitosis and cytokinesisthrough phosphorylation of substrates; may be aCdc28p substrate &radic0.911691&radic&radic&radic&radic&radic S000005242CLA4YNL298WverifiedCdc42p activated signal transducing kinase of the PAK(p21-activated kinase) family, involved inseptin ring assembly and cytokinesis; directlyphosphorylates septins Cdc3p and Cdc10p; otheryeast PAK family members are Ste20p and Skm1p &radic0.899791&radic&radic&radic&radic S000001865CAK1YFL029CverifiedCyclin-dependent kinase-activating kinase required for passagethrough the cell cycle, phosphorylates andactivates Cdc28p; nucleotide-binding pocketdiffers significantly from those of most otherprotein kinases &radic0.871761&radic&radic S000006130IPL1YPL209CverifiedAurora kinase involved in regulating kinetochore-microtubuleattachments; helps maintain condensedchromosomes during anaphase and earlytelophase; associates with Sli15p, whichpromotes Ipl1p association with mitotic spindle &radic0.837491&radic&radic&radic&radic S000000529KCC4YCL024WverifiedProtein kinase of the bud neck involved in the septincheckpoint, associates with septin proteins,negatively regulates Swe1p by phosphorylation,shows structural homology to bud neck kinasesGin4p and Hsl1p &radic0.865171&radic&radic S000001649TPK3YKL166CverifiedSubunit of cAMP-dependent protein kinase, which contains Tpk1p,Tpk2p, Tpk3p, and regulatory subunit Bcy1p;promotes growth in response to nutrients;mediates induction of apoptosis due toactin-mediated hyperactivation of Ras signaling &radic0.884491&radic&radic&radic&radic&radic S000006315DBF20YPR111WverifiedSer/Thr kinase involved in late nuclear division, one of themitotic exit network (MEN) proteins; necessaryfor the execution of cytokinesis &radic0.878341&radic&radic&radic&radic&radic S000004086KIN2YLR096WverifiedSerine/threonine protein kinase involved in regulation ofexocytosis; localizes to the cytoplasmic faceof the plasma membrane; closely related toKin1p &radic0.846491&radic&radic&radic&radic&radic S000000072CDC15YAR019CverifiedProtein kinase of the Mitotic Exit Network that is localized tothe spindle pole bodies at late anaphase;promotes mitotic exit by directly switching onthe kinase activity of Dbf2p &radic0.889991&radic&radic&radic&radic S000005376CMK2YOL016CverifiedCalmodulin-dependent protein kinase; may play a role in stressresponse, many CA++/calmodulan dependentphosphorylation substrates demonstrated invitro, amino acid sequence similar to Cmk1p andmammalian Cam Kinase II &radic0.840371&radic&radic&radic S000000263AKL1YBR059CverifiedSer-Thr protein kinase, member (with Ark1p and Prk1p) of theArk kinase family; involved in endocytosis andactin cytoskeleton organization &radic0.84651&radic&radic S000001248SCH9YHR205WverifiedProtein kinase that regulates signal transduction activity andG1 progression, controls cAPK activity,required for nitrogen activation of the FGMpathway, involved in life span regulation,homologous to mammalian Akt/PKB &radic0.848811&radic&radic&radic S000004354STE11YLR362WverifiedSignal transducing MEK kinase involved in pheromone responseand pseudohyphal/invasive growth pathways whereit phosphorylates Ste7p, and the highosmolarity response pathway, viaphosphorylation of Pbs2p; regulated by Ste20pand Ste50p &radic0.921481&radic&radic&radic&radic S000001144KIC1YHR102WverifiedProtein kinase of the PAK/Ste20 kinase family, required forcell integrity possibly through regulating1,6-beta-glucan levels in the wall; physicallyinteracts with Cdc31p (centrin), which is acomponent of the spindle pole body &radic0.888931&radic&radic S000000112FUS3YBL016WverifiedMitogen-activated protein kinase involved in mating pheromoneresponse; activated by phosphorylation bySte7p; provides specificity during the matingvs. filamentous growth response byphosphorylating transcriptional and cytoplasmictargets &radic0.873531&radic&radic&radic&radic S000002175CDC7YDL017WverifiedDDK (Dbf4-dependent kinase) catalytic subunit required forfiring origins and replication fork progressionin mitosis through phosphorylation of Mcm2-7pcomplexes and Cdc45p; kinase activitycorrelates with cyclical DBF4 expression &radic0.893661&radic&radic&radic&radic S000000364CDC28YBR160WverifiedCatalytic subunit of the main cell cycle cyclin-dependentkinase (CDK); alternately associates with G1cyclins (CLNs) and G2/M cyclins (CLBs) whichdirect the CDK to specific substrates &radic0.902081&radic&radic&radic S000003942KNS1YLL019CverifiedNonessential putative protein kinase of unknown cellular role;member of the LAMMER family of protein kinases,which are serine/threonine kinases also capableof phosphorylating tyrosine residues &radic0.853511&radic&radic&radic S000001072SLT2YHR030CverifiedSerine/threonine MAP kinase involved in regulating themaintenance of cell wall integrity andprogression through the cell cycle; regulatedby the PKC1-mediated signaling pathway &radic0.900921&radic&radic&radic&radic&radic&radic S000003701HAL5YJL165CverifiedPutative protein kinase; overexpression increases sodium andlithium tolerance, whereas gene disruptionincreases cation and low pH sensitivity andimpairs potassium uptake, suggesting a role inregulation of Trk1p and/or Trk2p transporters &radic0.861671&radic S000006074RAD53YPL153CverifiedProtein kinase, required for cell-cycle arrest in response toDNA damage; activated by transautophosphorylation when interacting withhyperphosphorylated Rad9p; also interacts withARS1 and plays a role in initiation of DNAreplication &radic0.912311&radic&radic&radic S000000601SAT4YCR008WverifiedSer/Thr protein kinase involved in salt tolerance; funtions inregulation of Trk1p-Trk2p potassiumtransporter; partially redundant with Hal5p;has similarity to Npr1p &radic0.88811&radic&radic&radic S000002259DUN1YDL101CverifiedCell-cycle checkpoint serine-threonine kinase required for DNAdamage-induced transcription of certain targetgenes, phosphorylation of Rad55p and Sml1p, andtransient G2/M arrest after DNA damage; alsoregulates postreplicative DNA repair &radic0.907991&radic&radic S000002266KIN28YDL108WverifiedSerine/threonine protein kinase, subunit of the transcriptionfactor TFIIH; involved in transcriptioninitiation at RNA polymerase II promoters &radic0.87211&radic&radic&radic S000002318STE7YDL159WverifiedSignal transducing MAP kinase kinase involved in pheromoneresponse, where it phosphorylates Fus3p, and inthe pseudohyphal/invasive growth pathway,through phosphorylation of Kss1p;phosphorylated by Ste11p, degraded by ubiquitinpathway &radic0.90321&radic&radic&radic S000005251MCK1YNL307CverifiedProtein serine/threonine/tyrosine (dual-specificity) kinaseinvolved in control of chromosome segregationand in regulating entry into meiosis; relatedto mammalian glycogen synthase kinases of theGSK-3 family &radic0.891111&radic&radic&radic&radic&radic S000001644YKL161CVerifiedProtein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; associates with Rlm1p &radic0.847541&radic&radic&radic&radic S000000999STE20YHL007CverifiedSignal transducing kinase of the PAK (p21-activated kinase)family, involved in pheromone response andpseudohyphal/invasive growth pathways,activated by Cdc42p; binds Ste4p at a GBB motifpresent in noncatalytic domains of PAK kinases &radic0.90481&radic&radic&radic&radic S000004710YPK2YMR104CverifiedProtein kinase with similarityto serine/threonine proteinkinase Ypk1p; functionally redundant with YPK1at the genetic level; participates in asignaling pathway required for optimal cellwall integrity; homolog of mammalian kinase SGK &radic0.861281&radic&radic&radic&radic S000006365SGV1YPR161CverifiedCyclin (Bur2p)-dependent protein kinase that functions intranscriptional regulation; phosphorylates thecarboxy-terminal domain of Rpo21p, which is thelargest subunit of RNA polymerase II; regulatedby Cak1p &radic0.88921&radic&radic S000005314SSK2YNR031CverifiedMAP kinase kinase kinase of the HOG1 mitogen-activatedsignaling pathway; interacts with Ssk1p,leading to autophosphorylation and activationof Ssk2p which phosphorylates Pbs2p; alsomediates actin cytoskeleton recovery fromosmotic stress &radic0.874331&radic&radic&radic S000002183YDL025CUncharacterizedPutative protein kinase, potentially phosphorylated by Cdc28p; YDL025C is not an essential gene &radic0.83551&radic S000006071YPL150WUncharacterizedHypothetical protein &radic0.8351&radic S000002691GCN2YDR283CverifiedProtein kinase, phosphorylates the alpha-subunit of translationinitiation factor eIF2 (Sui2p) in response tostarvation; activated by uncharged tRNAs andthe Gcn1p-Gcn20p complex &radic0.84981&radic&radic&radic S000001177YCK1YHR135CverifiedPalmitoylated, plasma membrane-bound casein kinase I isoform;shares redundant functions with Yck2p inmorphogenesis, proper septin assembly,endocytic trafficking; provides an essentialfunction overlapping with that of Yck2p &radic0.894171&radic&radic&radic&radic&radic&radic S000001124KSP1YHR082CverifiedNonessential putative serine/threonine protein kinase ofunknown cellular role; overproduction causesallele-specific suppression of the prp20-10mutation &radic0.854231&radic&radic&radic&radic S000002885SNF1YDR477WverifiedAMP-activated serine/threonine protein kinase found in acomplex containing Snf4p and members of theSip1p/Sip2p/Gal83p family; required fortranscription of glucose-repressed genes,thermotolerance, sporulation, and peroxisomebiogenesis &radic0.91751&radic&radic S000005405PSK2YOL045WverifiedOne of two (see also PSK1) PAS domain containing S/T proteinkinases; regulates sugar flux and translationin response to an unknown metabolite byphosphorylating Ugp1p and Gsy2p (sugar flux)and Caf20p, Tif11p and Sro9p (translation) &radic0.859721&radic&radic&radic&radic&radic&radic&radic S000000687KIN82YCR091WverifiedPutative serine/threonine protein kinase, most similar tocyclic nucleotide-dependent protein kinasesubfamily and the protein kinase C subfamily &radic0.845611&radic&radic&radic&radic&radic&radic S000001531ELM1YKL048CverifiedSerine/threonine protein kinase that regulates cellularmorphogenesis, septin behavior, andcytokinesis; required for the regulation ofother kinases; forms part of the bud neck ring &radic0.871871&radic&radic&radic&radic&radic S000001861RIM15YFL033CverifiedGlucose-repressible protein kinase involved in signaltransduction during cell proliferation inresponse to nutrients, specifically theestablishment of stationary phase; originallyidentified as a regulator of IME2 &radic0.879381&radic&radic S000005330YNR047WUncharacterizedPutative protein kinase that, when overexpressed, interferes with pheromone-induced growth arrest; localizes to the cytoplasm; potential Cdc28p substrate &radic0.863491&radic&radic&radic S000006124TPK2YPL203WverifiedSubunit of cytoplasmic cAMP-dependent protein kinase, whichcontains redundant catalytic subunits Tpk1p,Tpk2p, and Tpk3p and regulatory subunit Bcy1p;promotes vegetative growth in response tonutrients; activates filamentous growth &radic0.894421&radic&radic&radic&radic&radic&radic S000004965ARK1YNL020CverifiedSerine/threonine protein kinase involved in regulation of thecortical actin cytoskeleton; involved incontrol of endocytosis &radic0.86991&radic&radic S000000201PKC1YBL105CverifiedProtein serine/threonine kinase essential for cell wallremodeling during growth; localized to sites ofpolarized growth and the mother-daughter budneck; homolog of the alpha, beta, and gammaisoforms of mammalian protein kinase C (PKC) &radic0.864421&radic&radic&radic S000005793HRK1YOR267CverifiedProtein kinase implicated in activation of the plasma membraneH(+)-ATPase Pma1p in response to glucosemetabolism; plays a role in ion homeostasis &radic0.859551&radic&radic S000001357PRK1YIL095WverifiedProtein serine/threonine kinase; regulates the organization andfunction of the actin cytoskeleton through thephosphorylation of the Pan1p-Sla1p-End3pprotein complex &radic0.855851&radic&radic&radic S000003700TPK1YJL164CverifiedSubunit of cytoplasmic cAMP-dependent protein kinase, whichcontains redundant catalytic subunits Tpk1p,Tpk2p, and Tpk3p and regulatory subunit Bcy1p;promotes vegetative growth in response tonutrients; inhibits filamentous growth &radic0.883431&radic&radic&radic&radic&radic&radic S000003147TOS3YGL179CverifiedProtein kinase, related to and functionally redundant withElm1p and Sak1p for the phosphorylation andactivation of Snf1p; functionally orthologousto LKB1, a mammalian kinase associated withPeutz-Jeghers cancer-susceptibility syndrome &radic0.900781&radic&radic S000001297CKA1YIL035CverifiedAlpha catalytic subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA2, CKB1 and CKB2, the many substratesinclude transcription factors and all RNApolymerases &radic0.879621&radic&radic&radic&radic&radic S000000478CHK1YBR274WverifiedDNA damage checkpoint effector kinase, mediates mitotic cellcycle arrest via phosphorylation of Pds1p;phosphorylated by checkpoint signal transducerkinase Mec1p; homolog of S. pombe and mammalianChk1 checkpoint kinase &radic0.899581&radic&radic&radic S000003642IME2YJL106WverifiedSerine/threonine protein kinase involved in activation ofmeiosis, associates with Ime1p and mediates itsstability, activates Ndt80p; IME2 expression ispositively regulated by Ime1p &radic0.888091&radic S000000669SSK22YCR073CverifiedMAP kinase kinase kinase of the HOG1 mitogen-activatedsignaling pathway; functionally redundant with,and homologous to, Ssk2p; interacts with and isactivated by Ssk1p; phosphorylates Pbs2p &radic0.865371&radic&radic S000006062YPL141CUncharacterizedHypothetical protein &radic0.863571&radic&radic&radic&radic&radic&radic S000006258SMK1YPR054WverifiedMiddle sporulation-specific mitogen-activated protein kinase(MAPK) required for production of the outerspore wall layers; negatively regulatesactivity of the glucan synthase subunit Gsc2p &radic0.877561&radic&radic S000002915GIN4YDR507CverifiedProtein kinase involved in bud growth and assembly of theseptin ring, proposed to have kinase-dependentand kinase-independent activities; undergoesautophosphorylation; similar to Kcc4p and Hsl1p &radic0.912551&radic&radic S000000931SAK1YER129WverifiedUpstream kinase for the SNF1 complex; partially redundantfunction with Elm1p and Tos3p; members of thisfamily of kinases have functional orthologywith LKB1, a mammalian kinase associated withPeutz-Jeghers cancer-susceptibility syndrome &radic0.898621&radic&radic S000002237MRK1YDL079CverifiedGlycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3homologs in S. cerevisiae that function toactivate Msn2p-dependent transcription ofstress responsive genes and that function inprotein degradation &radic0.846421&radic S000003148ATG1YGL180WverifiedProtein serine/threonine kinase, required for autophagy and forthe cytoplasm-to-vacuole targeting (Cvt)pathway &radic0.861281&radic&radic S000005963SSN3YPL042CverifiedCyclin-dependent protein kinase, component of RNA polymerase IIholoenzyme; involved in phosphorylation of theRNA polymerase II C-terminal domain; involvedin glucose repression &radic0.885531&radic&radic&radic&radic&radic S000004103HOG1YLR113WverifiedMitogen-activated protein kinase involved in osmoregulation viathree independent osmosensors; mediates therecruitment and activation of RNA Pol II atHot1p-dependent promoters; localizationregulated by Ptp2p and Ptp3p &radic0.895121&radic&radic&radic&radic&radic S000003324DBF2YGR092WverifiedSer/Thr kinase involved in transcription and stress response;functions as part of a network of genes in exitfrom mitosis; localization is cell cycleregulated; activated by Cdc15p during the exitfrom mitosis &radic0.897851&radic&radic S000003272KSS1YGR040WverifiedMitogen-activated protein kinase (MAPK) involved in signaltransduction pathways that control filamentousgrowth and pheromone response &radic0.874021&radic&radic&radic S000005952PHO85YPL031CverifiedCyclin-dependent kinase, with ten cyclin partners; involved inenvironmental stress response; inphosphate-rich conditions, Pho85p-Pho80pcomplex phosphorylates Pho4p which in turnrepresses PHO5 &radic0.872911&radic&radic&radic&radic&radic&radic&radic S000000301VPS15YBR097WverifiedMyristoylated serine/threonine protein kinase involved invacuolar protein sorting; functions as amembrane-associated complex with Vps34p; activeform recruits Vps34p to the Golgi membrane;interacts with the GDP-bound form of Gpa1p &radic0.850391&radic S000005460PKH2YOL100WverifiedSerine/threonine protein kinase involved insphingolipid-mediated signaling pathway thatcontrols endocytosis; activates Ypk1p andYkr2p, components of signaling cascade requiredfor maintenance of cell wall integrity;redundant with Pkh1p &radic0.862251&radic&radic S000001622CTK1YKL139WverifiedCatalytic (alpha) subunit of C-terminal domain kinase I(CTDK-I), which phosphorylates the C-terminalrepeated domain of the RNA polymerase II largesubunit (Rpo21p) to affect both transcriptionand pre-mRNA 3' end processing &radic0.917971&radic&radic&radic&radic&radic&radic S000006061MKK2YPL140CverifiedMitogen-activated kinase kinase involved in protein kinase Csignaling pathway that controls cell integrity;upon activation by Bck1p phosphorylatesdownstream target, Slt2p; functionallyredundant with Mkk1p &radic0.904231&radic&radic&radic&radic S000003820PTK2YJR059WverifiedPutative serine/threonine protein kinase involved in regulationof ion transport across plasma membrane;enhances spermine uptake &radic0.858861&radic&radic S000002898PKH1YDR490CverifiedSerine/threonine protein kinase involved insphingolipid-mediated signaling pathway thatcontrols endocytosis; activates Ypk1p andYkr2p, components of signaling cascade requiredfor maintenance of cell wall integrity;redundant with Pkh2p &radic0.860221&radic S000003126RCK1YGL158WverifiedProtein kinase involved in the response to oxidative stress;identified as suppressor of S. pombe cell cyclecheckpoint mutations &radic0.896721&radic S000005757MKK1YOR231WverifiedMitogen-activated kinase kinase involved in protein kinase Csignaling pathway that controls cell integrity;upon activation by Bck1p phosphorylatesdownstream target, Slt2p; functionallyredundant with Mkk2p &radic0.834240.99352&radic&radic&radic S000002373PRR2YDL214CverifiedProtein kinase with a possible role in MAP kinase signaling inthe pheromone response pathway &radic0.828610.99352&radic&radic S000000015PSK1YAL017WverifiedOne of two (see also PSK2) PAS domain containing S/T proteinkinases; coordinately regulates proteinsynthesis and carbohydrate metabolism andstorage in response to a unknown metabolitethat reflects nutritional status &radic0.822760.99352&radic&radic&radic&radic S000000071KIN3YAR018CverifiedNonessential protein kinase with unknown cellular role &radic0.821310.99352&radic&radic&radic S000005098YCK2YNL154CverifiedPalmitoylated, plasma membrane-bound casein kinase I isoform;shares redundant functions with Yck1p inmorphogenesis, proper septin assembly,endocytic trafficking; provides an essentialfunction overlapping with that of Yck1p &radic0.820020.99352&radic&radic&radic&radic&radic&radic&radic S000002655VHS1YDR247WverifiedCytoplasmic serine/threonine protein kinase; identified as ahigh-copy suppressor of the synthetic lethalityof a sis2 sit4 double mutant, suggesting a rolein G1/S phase progression; homolog of Sks1p &radic0.832080.99352&radic&radic&radic&radic S000005105CBK1YNL161WverifiedSerine/threonine protein kinase that regulates cellmorphogenesis pathways; involved in cell wallbiosynthesis, apical growth, proper matingprojection morphology, bipolar bud siteselection in diploid cells, and cell separation &radic0.812060.99352&radic&radic&radic&radic&radic S000001910CMK1YFR014CverifiedCalmodulin-dependent protein kinase; may play a role in stressresponse, many CA++/calmodulan dependentphosphorylation substrates demonstrated invitro, amino acid sequence similar to Cmk2p andmammalian Cam Kinase II &radic0.831970.99352&radic&radic&radic&radic&radic&radic S000003677YAK1YJL141CverifiedSerine-threonine protein kinase that is part of aglucose-sensing system involved in growthcontrol in response to glucose availability;translocates from the cytoplasm to the nucleusand phosphorylates Pop2p in response to aglucose signal &radic0.831360.99352&radic&radic S000000232YBR028CUncharacterizedHypothetical protein &radic0.827750.99352&radic&radic S000001121IRE1YHR079CverifiedSerine-threonine kinase and endoribonuclease; transmembraneprotein that initiates the unfolded proteinresponse signal by regulating synthesis ofHac1p through HAC1 mRNA splicing &radic0.813080.99352&radic&radic&radic&radic S000006310ISR1YPR106WverifiedPredicted protein kinase, overexpression causes sensitivity tostaurosporine, which is a potent inhibitor ofprotein kinase C &radic0.792830.99352&radic&radic&radic&radic S000005127NPR1YNL183CverifiedProtein kinase that stabilizes several plasma membrane aminoacid transporters by antagonizing theirubiquitin-mediated degradation &radic0.828020.99352&radic&radic&radic&radic&radic S000005878MEK1YOR351CverifiedMeiosis-specific serine/threonine protein kinase, functions inmeiotic checkpoint, phosphorylates Red1p,interacts with Hop1p; required for meioticrecombination and normal spore viability &radic0.797480.99352&radic&radic&radic&radic S000002931SPS1YDR523CverifiedPutative protein serine/threonine kinase expressed at the endof meiosis and localized to the prosporemembrane, required for correct localization ofenzymes involved in spore wall synthesis &radic0.817470.99352&radic&radic&radic S000004905YMR291WUncharacterizedPutative kinase of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR291W is not an essential gene &radic0.833080.99352&radic&radic&radic&radic&radic&radic S000006125HRR25YPL204WverifiedProtein kinase involved in regulating diverse events includingvesicular trafficking, gene expression, DNArepair, and chromosome segregation; binds theCTD of RNA pol II; homolog of mammalian caseinkinase 1delta (CK1delta) &radic0.830310.99352&radic&radic&radic&radic&radic&radic S000003420BUB1YGR188CverifiedProtein kinase that forms a complex with Mad1p and Bub3p thatis crucial in the checkpoint mechanism requiredto prevent cell cycle progression into anaphasein the presence of spindle damage, associateswith centromere DNA via Skp1p &radic0.787270.99352&radic&radic S000000925YCK3YER123WverifiedPalmitoylated, vacuolar membrane-localized casein kinase Iisoform; negatively regulates vacuole fusionduring hypertonic stress via phosphorylation ofthe HOPS complex subunit, Vps41p; sharesoverlapping essential functions with Hrr25p &radic0.834050.99352&radic S000005759KIN4YOR233WverifiedKinase that acts by inhibiting the mitotic exit network (MEN)when the spindle position checkpoint isactivated; localized asymmetrically to mothercell cortex, spindle pole body and bud neck &radic0.798140.99352&radic&radic&radic&radic&radic S000001599PRR1YKL116CverifiedProtein kinase with a possible role in MAP kinase signaling inthe pheromone response pathway &radic0.813120.99352&radic&radic&radic&radic&radic S000004829SKY1YMR216CverifiedSR protein kinase (SRPK) involved in regulating proteinsinvolved in mRNA metabolism and cationhomeostasis; similar to human SRPK1 &radic0.832390.99352&radic&radic&radic&radic&radic S000001651KKQ8YKL168CverifiedPutative serine/threonine protein kinase with unknown cellularrole &radic0.790780.99352&radic&radic&radic&radic&radic S000001654YKL171WUncharacterizedPutative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm &radic0.820490.99352&radic&radic&radic S000002529KIN1YDR122WverifiedSerine/threonine protein kinase involved in regulation ofexocytosis; localizes to the cytoplasmic faceof the plasma membrane; closely related toKin2p &radic0.772710.99175&radic&radic&radic&radic S000003284FMP48YGR052WuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies &radic0.779810.99175&radic&radic&radic&radic S000005947SKS1YPL026CverifiedPutative serine/threonine protein kinase; involved in theadaptation to low concentrations of glucoseindependent of the SNF3 regulated pathway &radic0.778980.99175&radic&radic&radic&radic&radic S000003593IKS1YJL057CuncharacterizedPutative serine/threonine kinase; expression is induced duringmild heat stress; deletion mutants arehypersensitive to copper sulphate and resistantto sorbate; interacts with an N-terminalfragment of Sst2p 0.769810.98924&radic&radic S000002874PKH3YDR466WverifiedProtein kinase with similarity to mammalianphosphoinositide-dependent kinase 1 (PDK1) andyeast Pkh1p and Pkh2p, two redundant upstreamactivators of Pkc1p; identified as a multicopysuppressor of a pkh1 pkh2 double mutant &radic0.760810.98798&radic S000002186MPS1YDL028CverifiedDual-specificity kinase required for spindle pole body (SPB)duplication and spindle checkpoint function;substrates include SPB proteins Spc42p,Spc110p, and Spc98p, mitotic exit networkprotein Mob1p, and checkpoint protein Mad1p &radic0.764510.98798&radic S000005488YGK3YOL128CverifiedProtein kinase related to mammalian glycogen synthase kinasesof the GSK-3 family; GSK-3 homologs (Mck1p,Rim11p, Mrk1p, Ygk3p) are involved in controlof Msn2p-dependent transcription of stressresponsive genes and in protein degradation &radic0.73750.9851&radic&radic S000001681PTK1YKL198CverifiedPutative serine/threonine protein kinase that regulatesspermine uptake; involved in polyaminetransport; possible mitochondrial protein &radic0.720150.97692&radic&radic&radic&radic S000005206POL2YNL262WverifiedCatalytic subunit of DNA polymerase epsilon, one of the majorchromosomal DNA replication polymerasescharacterized by processivity and proofreadingexonuclease activity; also involved in DNAsynthesis during DNA repair &radic0.644730.95805&radic&radic&radic&radic&radic&radic S000003723SWE1YJL187CverifiedProtein kinase that regulates the G2/M transition by inhibitionof Cdc28p kinase activity; localizes to thenucleus and to the daughter side of themother-bud neck; homolog of S. pombe Wee1p;potential Cdc28p substrate &radic0.636440.95805&radic&radic&radic S000004296STT4YLR305CverifiedPhosphatidylinositol-4-kinase that functions in the Pkc1pprotein kinase pathway; required for normalvacuole morphology, cell wall integrity, andactin cytoskeleton organization &radic0.563460.95765&radic&radic S000000184TEL1YBL088CverifiedProtein kinase primarily involved in telomere lengthregulation; contributes to cell cyclecheckpoint control in response to DNA damage;functionally redundant with Mec1p; homolog ofhuman ataxia telangiectasia (ATM) gene &radic0.620180.95765&radic&radic&radic&radic S000001686TOR2YKL203CverifiedPIK-related protein kinase and rapamycin target; subunit ofTORC1, a complex that regulates growth inresponse to nutrients and TORC2, a complex thatregulates cell-cycle dependent polarization ofthe actin cytoskeleton; involved in meiosis &radic0.559390.95765&radic&radic&radic S000003664PBS2YJL128CverifiedMAP kinase kinase that plays a pivotal role in the osmosensingsignal-transduction pathway, activated undersevere osmotic stress &radic0.560.95765&radic S000001003PRS3YHL011Cverified5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involvedin nucleotide, histidine, and tryptophanbiosynthesis; one of a five related enzymes,which are active as heteromultimeric complexes &radic0.567970.95765&radic S000005868RPA190YOR341WverifiedRNA polymerase I subunit; largest subunit of RNA polymerase I &radic0.581070.95765&radic&radic&radic S000005473SKM1YOL113WverifiedMember of the PAK family of serine/threonine protein kinaseswith similarity to Ste20p and Cla4p; proposedto be a downstream effector of Cdc42p duringpolarized growth &radic0.623760.95765&radic S000005867RPA43YOR340CverifiedRNA polymerase I subunit A43 &radic0.582210.95765&radic&radic S000006157YPL236CUncharacterizedHypothetical protein &radic0.611060.95765&radic&radic S000005192RPA49YNL248CverifiedRNA polymerase I subunit A49 &radic0.601160.95765&radic&radic S000000340MEC1YBR136WverifiedGenome integrity checkpoint protein and PI kinase superfamilymember; signal transducer required for cellcycle arrest and transcriptional responsesprompted by damaged or unreplicated DNA;monitors and participates in meioticrecombination &radic0.604190.95765&radic S000005642RPO31YOR116CverifiedRNA polymerase III subunit C160, part of core enzyme; similarto bacterial beta-prime subunit &radic0.575260.95765&radic&radic&radic S000005046POL1YNL102WverifiedCatalytic subunit of the DNA polymerase alpha-primase complex,required for the initiation of DNA replicationduring mitotic DNA synthesis and premeiotic DNAsynthesis &radic0.560690.95765&radic&radic&radic&radic&radic S000002260CDC2YDL102WverifiedCatalytic subunit of DNA polymerase delta; required forchromosomal DNA replication during mitosis andmeiosis, intragenic recombination, repair ofdouble strand DNA breaks, and DNA replicationduring nucleotide excision repair (NER) &radic0.560440.95765&radic S000006214RPA135YPR010CverifiedRNA polymerase I subunit A135 &radic0.546150.95758 S000006391RPO26YPR187WverifiedRNA polymerase subunit ABC23, common to RNA polymerases I, II,and III; part of central core; similar tobacterial omega subunit &radic0.522540.95396&radic&radic&radic S000002299RPO21YDL140CverifiedRNA polymerase II largest subunit B220, part of central core;phosphorylation of C-terminal heptapeptiderepeat domain regulates association withtranscription and splicing factors; similar tobacterial beta-prime &radic0.521120.95396&radic&radic S000003827TOR1YJR066WverifiedPIK-related protein kinase and rapamycin target; subunit ofTORC1, a complex that controls growth inresponse to nutrients by regulatingtranslation, transcription, ribosomebiogenesis, nutrient transport and autophagy;involved in meiosis &radic0.51930.95389&radic&radic&radic S000005750RPB8YOR224CverifiedRNA polymerase subunit ABC14.5, common to RNA polymerases I,II, and III &radic0.515190.95304&radic&radic&radic S000001283RPB3YIL021WverifiedRNA polymerase II third largest subunit B44, part of centralcore; similar to prokaryotic alpha subunit &radic0.513450.95304&radic&radic&radic&radic S000006379DPB2YPR175WverifiedSecond largest subunit of DNA polymerase II (DNA polymeraseepsilon), required for normal yeast chromosomalreplication; expression peaks at the G1/S phaseboundary; potential Cdc28p substrate &radic0.516040.95304&radic&radic&radic S000001627RPC25YKL144CverifiedRNA polymerase III subunit C25 &radic0.513490.95304&radic&radic&radic S000005677RPB2YOR151CverifiedRNA polymerase II second largest subunit B150, part of centralcore; similar to bacterial beta subunit &radic0.512370.95253&radic&radic&radic&radic&radic&radic S000003824RPA12YJR063WverifiedRNA polymerase I subunit A12.2; contains two zinc bindingdomains, and the N terminal domain isresponsible for anchoring to the RNA pol Icomplex &radic0.500390.94929 S000001664PRS1YKL181Wverified5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involvedin nucleotide, histidine, and tryptophanbiosynthesis; one of five related enzymes,which are active as heteromultimeric complexes &radic0.499080.94814&radic&radic&radic&radic&radic S000006314RPC40YPR110CverifiedRNA polymerase subunit, common to RNA polymerase I and III &radic0.49780.94805&radic&radic&radic S000005057RPC19YNL113WverifiedRNA polymerase subunit, common to RNA polymerases I and III &radic0.47760.9465 S000005095RPC31YNL151CverifiedRNA polymerase III subunit C31; contains HMG-like C-terminaldomain &radic0.481730.9465&radic&radic S000005736RPB10YOR210WverifiedRNA polymerase subunit ABC10-beta, common to RNA polymerases I,II, and III &radic0.482980.9465&radic&radic&radic&radic S000005211PIK1YNL267WverifiedPhosphatidylinositol 4-kinase; catalyzes first step in thebiosynthesis ofphosphatidylinositol-4,5-biphosphate; maycontrol cytokineses through the actincytoskeleton &radic0.477980.9465&radic&radic S000004230VPS34YLR240WverifiedPhosphatidylinositol 3-kinase responsible for the synthesis ofphosphatidylinositol 3-phosphate; formsmembrane-associated signal transduction complexwith Vps15p to regulate protein sorting;activated by the GTP-bound form of Gpa1p &radic0.479290.9465&radic&radic&radic S000000358RPB5YBR154CverifiedRNA polymerase subunit ABC27, common to RNA polymerases I, II,and III; contacts DNA and affectstransactivation &radic0.463380.93854 S000005422PRS5YOL061Wverified5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involvedin nucleotide, histidine, and tryptophanbiosynthesis; one of a five related enzymes,which are active as heteromultimeric complexes &radic0.455780.93754&radic&radic&radic&radic&radic S000000901PRS2YER099Cverified5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involvedin nucleotide, histidine, and tryptophanbiosynthesis; one of a five related enzymes,which are active as heteromultimeric complexes &radic0.454440.93754&radic S000006394RPC82YPR190CverifiedRNA polymerase III subunit C82 &radic0.460410.93754&radic&radic&radic&radic S000006088REV3YPL167CverifiedCatalytic subunit of DNA polymerase zeta, which is involved inDNA repair and translesion synthesis; requiredfor mutagenesis induced by DNA damage &radic0.455020.93754&radic&radic S000002452RPC11YDR045CverifiedRNA polymerase III subunit C11; mediates pol III RNA cleavageactivity and is important for termination oftranscription &radic0.420910.92878 S000003051SCY1YGL083WverifiedPutative kinase, suppressor of GTPase mutant, similar to bovinerhodopsin kinase 0.40920.92442&radic&radic&radic S000000164PRS4YBL068Wverified5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involvedin nucleotide, histidine, and tryptophanbiosynthesis; one of a five related enzymes,which are active as heteromultimeric complexes &radic0.402310.92172&radic&radic&radic S000005365RPB11YOL005CverifiedRNA polymerase II subunit B12.5; part of central core; similarto Rpc19p and bacterial alpha subunit &radic0.399860.92138&radic&radic&radic S000002812RPB7YDR404CverifiedRNA polymerase II subunit B16; forms two subunit dissociablecomplex with Rpb4p &radic0.396210.91864&radic&radic&radic&radic S000002528DPB4YDR121WverifiedShared subunit of DNA polymerase epsilon and of ISW2/yCHRACchromatin accessibility complex; involved inboth chromosomal DNA replication and ininheritance of telomeric silencing &radic0.391870.91644&radic&radic&radic&radic&radic&radic S000005151RIO2YNL207WverifiedEssential serine kinase involved in the processing of the 20Spre-rRNA into mature 18S rRNA; has similarityto Rio1p &radic0.3880.91557&radic&radic&radic&radic&radic S000000224GAL1YBR020WverifiedGalactokinase, phosphorylates alpha-D-galactose toalpha-D-galactose-1-phosphate in the first stepof galactose catabolism; expression regulatedby Gal4p &radic0.383210.91541&radic S000001141TRA1YHR099WverifiedSubunit of SAGA and NuA4 histone acetyltransferase complexes;interacts with acidic activators (e.g., Gal4p)which leads to transcription activation;similar to human TRRAP, which is a cofactor forc-Myc mediated oncogenic transformation 0.383890.91541 S000005645RIO1YOR119CverifiedEssential serine kinase involved in cell cycle progression andprocessing of the 20S pre-rRNA into mature 18SrRNA &radic0.379850.91465&radic&radic&radic&radic&radic S000000829GAL83YER027CverifiedOne of three possible beta-subunits of the Snf1 kinase complex,allows nuclear localization of the Snf1 kinasecomplex in the presence of a nonfermentablecarbon source; contains glycogen-binding domain &radic0.377950.91246&radic S000003176SIP2YGL208WverifiedOne of three beta subunits of the Snf1 serine/threonine proteinkinase complex involved in the response toglucose starvation; null mutants exhibitaccelerated aging; N-myristoylprotein localizedto the cytoplasm and the plasma membrane &radic0.375380.9117&radic&radic&radic S000005475PAP2YOL115WverifiedCatalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), anuclear poly (A) polymerase complex involved inRNA quality control; catalyzes polyadenylationof unmodified tRNAs, and snoRNA and rRNAprecursors; disputed role as a DNA polymerase &radic0.37430.91136&radic S000002412MAF1YDR005CverifiedNegative regulator of RNA polymerase III; component of severalsignaling pathways that repress polymerase IIItranscription in response to changes incellular environment; targets the initiationfactor TFIIIB 0.37360.91035&radic&radic&radic S000003038RPB9YGL070CverifiedRNA polymerase II subunit B12.6; contacts DNA; mutations affecttranscription start site; involved in telomeremaintenance &radic0.371280.90748&radic&radic&radic&radic&radic S000002830SIP1YDR422CverifiedAlternate beta-subunit of the Snf1p kinase complex, may confersubstrate specificity; vacuolar proteincontaining KIS (Kinase-Interacting Sequence)and ASC (Association with Snf1 kinase Complex)domains involved in protein interactions &radic0.364110.90476&radic&radic&radic&radic&radic S000002924EMI2YDR516CverifiedNon-essential protein of unknown function required fortranscriptional induction of the earlymeiotic-specific transcription factor IME1;required for sporulation; expression isregulated by glucose-repression transcriptionfactors Mig1/2p 0.363960.90446&radic&radic S000004337YLR345WUncharacterizedSimilar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene &radic0.363210.90362&radic&radic&radic&radic S000000828CHO1YER026CverifiedPhosphatidylserine synthase, functions in phospholipidbiosynthesis; catalyzes the reactionCDP-diaclyglycerol + L-serine = CMP +L-1-phosphatidylserine, transcriptionallyrepressed by myo-inositol and choline &radic0.362570.90362 S000000482DPB3YBR278WverifiedThird-largest subunit of DNA polymerase II (DNA polymeraseepsilon), required to maintain fidelity ofchromosomal replication and also forinheritance of telomeric silencing; mRNAabundance peaks at the G1/S boundary of thecell cycle &radic0.359050.90345&radic&radic S000001933RSC8YFR037CverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; essential for viability andmitotic growth; homolog of SWI/SNF subunitSwi3p, but unlike Swi3p, does not activatetranscription of reporters 0.358670.90333&radic&radic&radic S000001733RPC37YKR025WverifiedRNA polymerase III subunit C37 &radic0.355820.90318&radic&radic&radic&radic&radic&radic S000004320NMA1YLR328WverifiedNicotinic acid mononucleotide adenylyltransferase, involved inNAD(+) salvage pathway &radic0.348150.89781&radic&radic&radic&radic&radic S000005074CPT1YNL130CverifiedCholinephosphotransferase, required for phosphatidylcholinebiosynthesis and for inositol-dependentregulation of EPT1 transcription &radic0.347650.89744 S000001369PFK26YIL107Cverified6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate andsn-glycerol 3-phosphate, has negligiblefructose-2,6-bisphosphatase activity,transcriptional regulation involves proteinkinase A &radic0.341290.89593&radic&radic S000001165EPT1YHR123Wverifiedsn-1,2-diacylglycerol ethanolamine- andcholinephosphotranferase; not essential forviability &radic0.339010.89401&radic&radic&radic&radic S000001924CDC14YFR028CverifiedProtein phosphatase required for mitotic exit; located in thenucleolus until liberated by the FEAR andMitotic Exit Network in anaphase, enabling itto act on key substrates to effect a decreasein CDK/B-cyclin activity and mitotic exit 0.338870.89331&radic S000003011DST1YGL043WverifiedGeneral transcription elongation factor TFIIS, enables RNApolymerase II to read through blocks toelongation by stimulating cleavage of nascenttranscripts stalled at transcription arrestsites 0.336780.89265&radic S000003548RPC17YJL011CverifiedRNA polymerase III subunit C17; physically interacts with C31,C11, and TFIIIB70; may be involved in therecruitment of pol III by the preinitiationcomplex &radic0.335750.89199&radic S000001075YHR033WUncharacterizedPutative protein of unknown function; epitope-tagged protein localizes to the cytoplasm 0.333950.89028&radic&radic&radic&radic S000003222HXK2YGL253WverifiedHexokinase isoenzyme 2 that catalyzes phosphorylation ofglucose in the cytosol; predominant hexokinaseduring growth on glucose; functions in thenucleus to repress expression of HXK1 and GLK1and to induce expression of its own gene &radic0.327750.88888&radic&radic&radic&radic&radic S000003494BUD32YGR262CverifiedProtein kinase proposed to be involved in bud-site selection,telomere uncapping and elongation, andtranscription; component of the EKC/KEOPSprotein complex with Kae1p, Cgi121p, Pcc1p, andGon7p &radic0.327860.88888&radic&radic&radic S000003242NMA2YGR010WverifiedNicotinic acid mononucleotide adenylyltransferase, involved inNAD(+) salvage pathway &radic0.315240.88386&radic&radic&radic S000001949HXK1YFR053CverifiedHexokinase isoenzyme 1, a cytosolic protein that catalyzesphosphorylation of glucose during glucosemetabolism; expression is highest during growthon non-glucose carbon sources; glucose-inducedrepression involves the hexokinase Hxk2p &radic0.312330.88211&radic&radic&radic&radic&radic S000006317PIS1YPR113WverifiedPhosphatidylinositol synthase, required for biosynthesis ofphosphatidylinositol, which is a precursor forpolyphosphoinositides, sphingolipids, andglycolipid anchors for some of the plasmamembrane proteins &radic0.311710.88149&radic&radic S000004123CKI1YLR133WverifiedCholine kinase, catalyzes the first step in the CDP-cholinepathway phosphatidylcholine synthesis (Kennedypathway); mRNA expression is regulated byinositol and choline, enzyme activity isstimulated by phosphorylation by protein kinase &radic0.308120.88047&radic&radic&radic&radic S000002416GAL3YDR009WverifiedTranscriptional regulator involved in activation of the GALgenes in response to galactose; forms a complexwith Gal80p to relieve Gal80p inhibition ofGal4p; binds galactose and ATP but does nothave galactokinase activity 0.30680.87961&radic&radic S000006236SRO7YPR032WverifiedPutative effector of Rab GTPase Sec4p, forms a complex withSec4p and t-SNARE Sec9p; involved in exocytosisand docking and fusion of post-Golgi vesicleswith plasma membrane; homolog of Sro77p andDrosophila lgl tumor suppressor 0.304230.87835&radic S000005243TRF5YNL299WverifiedPoly (A) polymerase involved in nuclear RNA quality controlbased on: homology with Trf4p, geneticinteractions with TRF4 mutants, physicalinteraction with Mtr4p (TRAMP subunit), and bydirect assay; disputed role as a sigma DNApolymerase &radic0.304060.87825&radic&radic&radic S000005286RPC34YNR003CverifiedRNA polymerase III subunit C34; interacts with TFIIIB70 and isa key determinant in pol III recruitment by thepreinitiation complex &radic0.302520.87797&radic S000002301CRD1YDL142CverifiedCardiolipin synthase; produces cardiolipin, which is animportant constituent of mitochondrialmembranes; required for normal mitochondrialmembrane potential and function &radic0.29890.87737&radic S000002634ADK1YDR226WverifiedAdenylate kinase, required for purine metabolism; localized tothe cytoplasm and the mitochondria; lackscleavable signal sequence &radic0.295570.87514&radic&radic&radic&radic&radic&radic&radic S000000131POL12YBL035CverifiedB subunit of DNA polymerase alpha-primase complex, required forinitiation of DNA replication during mitoticand premeiotic DNA synthesis; also functions intelomere capping and length regulation &radic0.291430.87296&radic&radic&radic S000002554EKI1YDR147WverifiedEthanolamine kinase, primarily responsible forphosphatidylethanolamine synthesis via theCDP-ethanolamine pathway; also exhibits cholinekinase activity &radic0.290170.87202&radic&radic S000000545GLK1YCL040WverifiedGlucokinase, catalyzes the phosphorylation of glucose at C6 inthe first irreversible step of glucosemetabolism; one of three glucosephosphorylating enzymes; expression regulatedby non-fermentable carbon sources &radic0.284460.86966&radic&radic&radic&radic S000006179THI21YPL258CverifiedHydroxymethylpyrimidine phosphate kinase, involved in the laststeps in thiamine biosynthesis; member of agene family with THI20 and THI22; functionallyredundant with Thi20p &radic0.283530.8693&radic&radic&radic S000002304COP1YDL145CverifiedAlpha subunit of COPI vesicle coatomer complex, which surroundstransport vesicles in the early secretorypathway 0.28180.86858&radic S000003691FBP26YJL155CverifiedFructose-2,6-bisphosphatase, required for glucose metabolism &radic0.280150.86676&radic&radic&radic&radic S000005733RET1YOR207CverifiedSecond-largest subunit of RNA polymerase III, which isresponsible for the transcription of tRNA and5S RNA genes, and other low molecular weightRNAs &radic0.276290.86492&radic&radic&radic&radic S000005416THI20YOL055CverifiedMultifunctional protein with both hydroxymethylpyrimidinekinase and thiaminase activities; involved inthiamine biosynthesis and also in thiaminedegradation; member of a gene family with THI21and THI22; functionally redundant with Thi21p &radic0.262340.85634&radic&radic&radic&radic&radic S000000552YCL047CUncharacterizedPutative protein of unknown function 0.261570.85574&radic S000004722ASC1YMR116CverifiedWD repeat protein (G-beta like protein) involved in translationregulation; required for repression of Gcn4pactivity in the absence of amino-acidstarvation; core component of the ribosome;ortholog of mammalian RACK1 0.256270.85293&radic S000005261PFS2YNL317WverifiedIntegral subunit of the pre-mRNA cleavage and polyadenylationfactor (CPF) complex; plays an essential rolein mRNA 3'-end formation by bridging differentprocessing factors and thereby promoting theassembly of the processing complex 0.252920.85089&radic&radic&radic S000003124AMS1YGL156WverifiedVacuolar alpha mannosidase, involved in free oligosaccharide(fOS) degradation; delivered to the vacuole ina novel pathway separate from the secretorypathway 0.247570.84615 S000002319DHH1YDL160CverifiedCytoplasmic DExD/H-box helicase, stimulates mRNA decapping,coordinates distinct steps in mRNA function anddecay, interacts with both the decapping anddeadenylase complexes, may have a role in mRNAexport and translation 0.246620.84534&radic&radic S000001508PAN3YKL025CverifiedEssential subunit of the Pan2p-Pan3p poly(A)-ribonucleasecomplex, which acts to control poly(A) taillength and regulate the stoichiometry andactivity of postreplication repair complexes 0.242660.84134&radic&radic&radic&radic&radic&radic S000001024GUT1YHL032CverifiedGlycerol kinase, converts glycerol to glycerol-3-phosphate;glucose repression of expression is mediated byAdr1p and Ino2p-Ino4p; derepression ofexpression on non-fermentable carbon sources ismediated by Opi1p and Rsf1p &radic0.233630.83438&radic&radic&radic S000004821ERG12YMR208WverifiedMevalonate kinase, acts in the biosynthesis of isoprenoids andsterols, including ergosterol, from mevalonate &radic0.225760.82994&radic&radic&radic S000003810UTR1YJR049CverifiedATP-NADH kinase; phosphorylates both NAD and NADH; active as ahexamer; enhances the activity of ferricreductase (Fre1p) &radic0.226060.82994&radic&radic&radic S000002309RPC53YDL150WverifiedRNA polymerase III subunit C53 &radic0.223880.82956&radic&radic S000002516YDR109CUncharacterizedHypothetical protein &radic0.222220.82906&radic&radic&radic S000003418TFG1YGR186WverifiedTFIIF (Transcription Factor II) largest subunit; involved inboth transcription initiation and elongation ofRNA polymerase II; homologous to human RAP74 0.219950.82691&radic&radic&radic&radic S000003676RPB4YJL140WverifiedRNA polymerase II subunit B32; forms two subunit dissociablecomplex with Rpb7p; dispensable under someenvironmental conditions; involved in export ofmRNA to cytoplasm under stress conditions;involved in telomere maintenance &radic0.219140.82637&radic&radic S000005873REV1YOR346WverifiedDeoxycytidyl transferase, forms a complex with the subunits ofDNA polymerase zeta, Rev3p and Rev7p; involvedin repair of abasic sites in damaged DNA &radic0.217530.82557&radic&radic&radic S000006109POS5YPL188WverifiedMitochondrial NADH kinase, phosphorylates NADH; alsophosphorylates NAD(+) with lower specificity;required for the response to oxidative stress &radic0.217120.82557&radic&radic&radic S000003636LSB6YJL100WverifiedPhosphatidylinositol 4-kinase that binds Las17p, which is ahomolog of human Wiskott-Aldrich Syndromeprotein involved in actin patch assembly andactin polymerization &radic0.21430.82295&radic S000001543FBA1YKL060CverifiedFructose 1,6-bisphosphate aldolase, required for glycolysis andgluconeogenesis; catalyzes conversion offructose 1,6 bisphosphate to glyceraldehyde-3-Pand dihydroxyacetone-P; locates tomitochondrial outer surface upon oxidativestress 0.21350.82171&radic&radic S000003237TFG2YGR005CverifiedTFIIF (Transcription Factor II) middle subunit; involved inboth transcription initiation and elongation ofRNA polymerase II; homologous to human RAP30 0.213270.82128&radic S000000767YEF1YEL041WverifiedATP-NADH kinase; phosophorylates both NAD and NADH;homooctameric structure consisting of 60-kDasubunits; sequence similarity to Utr1p andPos5p; overexpression complements certain pos5phenotypes &radic0.208820.81748 S000003766HYS2YJR006WverifiedDNA polymerase III (delta) subunit, essential for cellviability; involved in DNA replication and DNArepair &radic0.20490.81515&radic S000001507URA6YKL024CverifiedUridylate kinase, catalyzes the seventh enzymatic step in thede novo biosynthesis of pyrimidines, convertinguridine monophosphate (UMP) intouridine-5'-diphosphate (UDP) &radic0.196260.80948&radic&radic&radic&radic&radic&radic&radic S000001067THR1YHR025WverifiedHomoserine kinase, conserved protein required for threoninebiosynthesis; expression is regulated by theGCN4-mediated general amino acid controlpathway &radic0.195330.80939&radic&radic S000003509YGR277CUncharacterizedPutative protein of unknown function; sequence similarity to Pantetheine-phosphate adenylyltransferase (PPAT); YGR277C is an essential gene &radic0.192380.80787&radic&radic S000004818PFK2YMR205CverifiedBeta subunit of heterooctameric phosphofructokinase involved inglycolysis, indispensable for anaerobic growth,activated by fructose-2,6-bisphosphate and AMP,mutation inhibits glucose induction of cellcycle-related genes &radic0.192360.80787&radic&radic&radic&radic S000001710PAP1YKR002WverifiedPoly(A) polymerase, one of three factors required for mRNA3'-end polyadenylation, forms multiproteincomplex with polyadenylation factor I (PF I),also required for mRNA nuclear export; may alsopolyadenylate rRNAs &radic0.190660.80738&radic&radic&radic&radic&radic S000004833ERG8YMR220WverifiedPhosphomevalonate kinase, an essential cytosolic enzyme thatacts in the biosynthesis of isoprenoids andsterols, including ergosterol, from mevalonate &radic0.186910.8012&radic&radic&radic&radic&radic&radic&radic S000006050TAF14YPL129WverifiedSubunit (30 kDa) of TFIID, TFIIF, and SWI/SNF complexes,involved in RNA polymerase II transcriptioninitiation and in chromatin modification,contains a YEATS domain 0.18430.79755&radic&radic S000002580ARG82YDR173CverifiedInositol polyphosphate multikinase (IPMK), sequentiallyphosphorylates Ins(1,4,5)P3 to formIns(1,3,4,5,6)P5; putative nuclear lipidinositol PI3-kinase; regulates arginine-,phosphate-, and nitrogen-responsive genes &radic0.183380.796&radic&radic&radic&radic&radic&radic S000003087ABC1YGL119WverifiedProtein required for ubiquinone (coenzyme Q) biosynthesis andfor respiratory growth; exhibits geneticinteraction with COQ9, suggesting a commonfunction; similar to prokaryotic proteinsinvolved in early steps of ubiquinonebiosynthesis 0.181080.79441&radic&radic S000002827RAD30YDR419WverifiedDNA polymerase eta, involved in the predominantly error-freebypass replication of DNA lesions, catalyzesthe efficient and accurate synthesis of DNAopposite cyclobutane pyrimidine dimers; homologof human POLH and bacterial DinB proteins &radic0.177090.79031&radic&radic&radic S000005838HSD1YOR311CverifiedEndoplasmic reticulum (ER)-resident membrane protein,overproduction induces enlargement of ER-likemembrane structures and suppresses atemperature-sensitive sly1 mutation 0.174110.78573&radic&radic S000003434PCT1YGR202CverifiedCholinephosphate cytidylyltransferase, also known asCTP:phosphocholine cytidylyltransferase,rate-determining enzyme of the CDP-cholinepathway for phosphatidylcholine synthesis,inhibited by Sec14p, activated uponlipid-binding &radic0.172750.78443&radic S000007261AI1Q0050verifiedReverse transcriptase required for splicing of the COX1pre-mRNA, encoded by a mobile group II intronwithin the mitochondrial COX1 gene 0.170520.78292 S000002427YDR020CUncharacterizedPredicted protein shares weak similarity with uridine kinases and with phosphoribokinases; null exhibits no apparent phenotype 0.170170.78213&radic&radic&radic S000003472PFK1YGR240CverifiedAlpha subunit of heterooctameric phosphofructokinase involvedin glycolysis, indispensable for anaerobicgrowth, activated by fructose-2,6-bisphosphateand AMP, mutation inhibits glucose induction ofcell cycle-related genes &radic0.169040.78204&radic&radic&radic&radic&radic S000003239MUQ1YGR007WverifiedCholine phosphate cytidylyltransferase, catalyzes the secondstep of phosphatidylethanolamine biosynthesis;involved in the maintenance of plasma membrane;similar to mammalian CTP: phosphocholinecytidylyl-transferases &radic0.168980.78195&radic&radic&radic&radic&radic&radic S000002989ALK1YGL021WverifiedProtein kinase; accumulation and phosphorylation are periodicduring the cell cycle; phosphorylated inresponse to DNA damage; contains characteristicmotifs for degradation via the APC pathway;similar to Alk2p and to mammalian haspins &radic0.168030.78103&radic&radic&radic&radic S000001004YHL012WUncharacterizedPutative protein of unknown function, has some homology to Ugp1p, which encodes UDP-glucose pyrophosphorylase 0.16620.77743&radic&radic&radic S000005697LCB4YOR171CverifiedSphingoid long-chain base kinase, responsible for synthesis oflong-chain base phosphates, which function assignaling molecules, regulates synthesis ofceramide from exogenous long-chain bases,localizes to the Golgi and late endosomes &radic0.166810.77743&radic&radic S000002273IWR1YDL115CuncharacterizedProtein of unknown function, deletion causes hypersensitivityto the K1 killer toxin 0.165480.77707&radic&radic&radic S000003122LYS5YGL154CverifiedPhosphopantetheinyl transferase involved in lysinebiosynthesis; converts inactive apo-form ofLys2p (alpha-aminoadipate reductase) intocatalytically active holo-form byposttranslational addition ofphosphopantetheine &radic0.164870.77659 S000000972ADK2YER170WverifiedMitochondrial adenylate kinase, catalyzes the reversiblesynthesis of GTP and AMP from GDP and ADP; mayserve as a back-up for synthesizing GTP or ADPdepending on metabolic conditions; 3' sequenceof ADK2 varies with strain background &radic0.161920.77263&radic S000001409SLN1YIL147CverifiedHistidine kinase osmosensor that regulates a MAP kinasecascade; transmembrane protein with anintracellular kinase domain that signals toYpd1p and Ssk1p, thereby forming a phosphorelaysystem similar to bacterial two-componentregulators &radic0.161020.77197&radic S000003083SNF4YGL115WverifiedProtein kinase activator found in a complex containing Snf1pand members of the Sip1p/Sip2p/Gal83p family;activates the Snf1p protein kinase; involved inexpression of glucose-repressed genes,sporulation, and peroxisome biogenesis 0.15970.76928&radic&radic S000003426XKS1YGR194CverifiedXylulokinase, converts D-xylulose and ATP to xylulose5-phosphate and ADP; rate limiting step infermentation of xylulose; required for xylosefermentation by recombinant S. cerevisiaestrains &radic0.158190.76716&radic&radic&radic&radic S000004470SPT5YML010WverifiedProtein that forms a complex with Spt4p and mediates bothactivation and inhibition of transcriptionelongation; Spt4p-Spt5p complex also plays arole in pre-mRNA processing 0.158610.76716&radic&radic&radic&radic S000005310BUD17YNR027WverifiedProtein involved in bud-site selection; diploid mutants displaya random budding pattern instead of thewild-type bipolar pattern 0.158030.76694&radic&radic S000006152FAS2YPL231WverifiedAlpha subunit of fatty acid synthetase, which catalyzes thesynthesis of long-chain saturated fatty acids;contains beta-ketoacyl reductase andbeta-ketoacyl synthase activities &radic0.157230.76686&radic&radic&radic&radic&radic S000002435REG1YDR028CverifiedRegulatory subunit of type 1 protein phosphatase Glc7p,involved in negative regulation ofglucose-repressible genes 0.156610.76576&radic S000006069PPT2YPL148CverifiedPhosphopantetheine:protein transferase (PPTase), activatesmitochondrial acyl carrier protein (Acp1p) byphosphopantetheinylation &radic0.152020.75845 S000005026PMS1YNL082WverifiedATP-binding protein required for mismatch repair in mitosis andmeiosis; functions as a heterodimer with Mlh1p,binds double- and single-stranded DNA via itsN-terminal domain, similar to E. coli MutL 0.152650.75845&radic&radic S000006030YPL109CUncharacterizedHypothetical protein 0.150390.75714&radic&radic&radic S000003295SPT4YGR063CverifiedProtein that forms a complex with Spt5p and mediates bothactivation and inhibition of transcriptionelongation, and plays a role in pre-mRNAprocessing; in addition, Spt4p is involved inkinetochore function and gene silencing 0.150310.755&radic S000006325THI22YPR121WverifiedProtein with similarity to hydroxymethylpyrimidine phosphatekinases; member of a gene family with THI20 andTHI21; not required for thiamine biosynthesis &radic0.149280.75373&radic&radic S000004535DAK1YML070WverifiedDihydroxyacetone kinase, required for detoxification ofdihydroxyacetone (DHA); involved in stressadaptation &radic0.148960.75276&radic&radic S000004243YLR253WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene 0.148540.75264&radic&radic&radic&radic S000002616MSS4YDR208WverifiedPhosphatidylinositol-4-phosphate 5-kinase, involved in actincytoskeleton organization and cellmorphogenesis; multicopy suppressor of stt4mutation &radic0.148510.75264&radic&radic&radic&radic S000001841DAK2YFL053WverifiedDihydroxyacetone kinase, required for detoxification ofdihydroxyacetone (DHA); involved in stressadaptation &radic0.148540.75264&radic&radic S000003543CTK2YJL006CverifiedBeta subunit of C-terminal domain kinase I (CTDK-I), whichphosphorylates the C-terminal repeated domainof the RNA polymerase II large subunit (Rpo21p)to affect both transcription and pre-mRNA 3'end processing; has similarity to cyclins 0.145190.74786&radic S000000036CDC19YAL038WverifiedPyruvate kinase, functions as a homotetramer in glycolysis toconvert phosphoenolpyruvate to pyruvate, theinput for aerobic (TCA cycle) or anaerobic(glucose fermentation) respiration &radic0.143270.74623&radic&radic&radic&radic&radic S000004438YLR446WUncharacterizedPutative protein of unknown function with similarity to hexokinases; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene 0.142340.74506 S000000613PET18YCR020CverifiedProtein required for respiratory growth and stability of themitochondrial genome 0.139480.73962&radic&radic&radic&radic S000002987CKB1YGL019WverifiedBeta regulatory subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKA2 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.13850.73753&radic&radic&radic S000003866ADO1YJR105WverifiedAdenosine kinase, required for the utilization ofS-adenosylmethionine (AdoMet); may be involvedin recycling adenosine produced through themethyl cycle &radic0.136770.73362&radic&radic&radic S000000979BMH1YER177Wverified14-3-3 protein, major isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others 0.134780.72912&radic S000001013FMP12YHL021CuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.133170.72776&radic&radic&radic&radic&radic S000002424KCS1YDR017CverifiedInositol hexaphosphate kinase, phosphorylates inositolhexakisphosphate (InsP6) to diphosphoinositolpolyphosphates, required for proper vacuolemorphology and involved in salt stressresponse, contains two leucine heptad repeats &radic0.131720.72622&radic S000003996SSK1YLR006CverifiedCytoplasmic response regulator, part of a two-component signaltransducer that mediates osmosensing via aphosphorelay mechanism; dephosphorylated formis degraded by the ubiquitin-proteasome system;potential Cdc28p substrate 0.125030.71763&radic&radic&radic&radic&radic&radic S000005199GIS2YNL255CverifiedProtein with seven cysteine-rich CCHC zinc-finger motifs,similar to human CNBP, proposed to be involvedin the RAS/cAMP signaling pathway 0.123130.71447&radic&radic&radic&radic&radic S000005326MVD1YNR043WverifiedMevalonate pyrophosphate decarboxylase, essential enzymeinvolved in the biosynthesis of isoprenoids andsterols, including ergosterol; acts as ahomodimer 0.122490.71384&radic&radic S000005743RFC1YOR217WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon 0.120420.71166&radic&radic&radic&radic S000002334AIR2YDL175CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p; may regulatemethylation of Npl3p, which modulates Npl3pfunction in mRNA processing and export; hassimilarity to Air1p &radic0.120090.71021&radic&radic S000004250LCB5YLR260WverifiedMinor sphingoid long-chain base kinase, paralog of Lcb4presponsible for few percent of the totalactivity, possibly involved in synthesis oflong-chain base phosphates, which function assignaling molecules &radic0.119780.70997&radic&radic S000005032TOP2YNL088WverifiedEssential type II topoisomerase, relieves torsional strain inDNA by cleaving and re-sealing thephosphodiester backbone of both positively andnegatively supercoiled DNA; cleavescomplementary strands; localizes to axial coresin meiosis 0.117480.70566&radic S000005496PFK27YOL136Cverified6-phosphofructo-2-kinase, catalyzes synthesis offructose-2,6-bisphosphate; inhibited byphosphoenolpyruvate and sn-glycerol3-phosphate, expression induced by glucose andsucrose, transcriptional regulation involvesprotein kinase A &radic0.117310.70564&radic&radic&radic S000005234RFC3YNL290WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon 0.116050.70398&radic&radic&radic&radic&radic S000004975HHF2YNL030WverifiedOne of two identical histone H4 proteins (see also HHF1); corehistone required for chromatin assembly andchromosome function; contributes to telomericsilencing; N-terminal domain involved inmaintaining genomic integrity 0.114510.70014&radic S000005874PYK2YOR347CverifiedPyruvate kinase that appears to be modulated byphosphorylation; PYK2 transcription isrepressed by glucose, and Pyk2p may be activeunder low glycolytic flux &radic0.113580.69908&radic&radic&radic&radic&radic S000000854HOM3YER052CverifiedAspartate kinase (L-aspartate 4-P-transferase); cytoplasmicenzyme that catalyzes the first step in thecommon pathway for methionine and threoninebiosynthesis; expression regulated by Gcn4p andthe general control of amino acid synthesis &radic0.108250.69189&radic&radic&radic S000004777MLH1YMR167WverifiedProtein required for mismatch repair in mitosis and meiosis,postmeiotic segregation, and spore viability;forms a complex with Pms1p and Msh2p to repairmismatched DNA; human homolog is associatedwith hereditary non-polyposis colon cancer 0.107870.69029&radic&radic&radic S000004106MSL5YLR116WverifiedComponent of the commitment complex, which defines the firststep in the splicing pathway; essential proteinthat interacts with Mud2p and Prp40p, forming abridge between the intron ends; also involvedin nuclear retention of pre-mRNA 0.107550.6897&radic&radic&radic&radic S000001447PRI1YIR008CverifiedSubunit of DNA primase, which is required for DNA synthesis anddouble-strand break repair &radic0.107370.68919 S000006311YTH1YPR107CverifiedEssential RNA-binding component of cleavage and polyadenylationfactor, contains five zinc fingers; requiredfor pre-mRNA 3'-end processing andpolyadenylation 0.106190.68765&radic&radic&radic&radic&radic S000002708PRO1YDR300CverifiedGamma-glutamyl kinase, catalyzes the first step in prolinebiosynthesis &radic0.100950.6812&radic&radic&radic&radic S000003754YJL218WUncharacterizedPutative protein of unknown function, similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene 0.100130.67912&radic&radic&radic S000000105ALK2YBL009WverifiedProtein kinase; accumulation and phosphorylation are periodicduring the cell cycle; phosphorylated inresponse to DNA damage; contains characteristicmotifs for degradation via the APC pathway;similar to Alk1p and to mammalian haspins &radic0.09970.67905&radic&radic S000001249SKN7YHR206WverifiedNuclear response regulator and transcription factor, part of abranched two-component signaling system;required for optimal induction of heat-shockgenes in response to oxidative stress; involvedin osmoregulation 0.098150.67638&radic&radic&radic&radic S000002619GCD6YDR211WverifiedCatalytic epsilon subunit of the translation initiation factoreIF2B, the guanine-nucleotide exchange factorfor eIF2; activity subsequently regulated byphosphorylated eIF2; first identified as anegative regulator of GCN4 expression 0.096650.67353&radic&radic&radic&radic S000003567MAD2YJL030WverifiedComponent of the spindle-assembly checkpoint complex, whichdelays the onset of anaphase in cells withdefects in mitotic spindle assembly; forms acomplex with Mad1p 0.09630.67353&radic&radic S000006161HSP82YPL240CverifiedCytoplasmic chaperone (Hsp90 family) required for pheromonesignaling and negative regulation of Hsf1p;docks with the mitochondrial import receptorTom70p for preprotein delivery; interacts withco-chaperones Cns1p, Cpr6p, Cpr7p, and Sti1p 0.095680.67245&radic&radic&radic&radic S000001341AIR1YIL079CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p to regulate methylationof Npl3p, which modulates Npl3p function inmRNA processing and export; has similarity toAir2p &radic0.09570.67245&radic&radic&radic&radic S000004798HSC82YMR186WverifiedCytoplasmic chaperone of the Hsp90 family, redundant infunction and nearly identical with Hsp82p, andtogether they are essential; expressedconstitutively at 10-fold higher basal levelsthat HSP82 and induced 2-3 fold by heat shock 0.09540.67224&radic&radic&radic S000000373SSE2YBR169CverifiedMember of the heat shock protein 70 (HSP70) family; may beinvolved in protein folding; localized to thecytoplasm; highly homologous to the heat shockprotein Sse1p 0.095260.67151&radic&radic S000000291RFC5YBR087WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon 0.09370.6697&radic S000001739SPO14YKR031CverifiedPhospholipase D, catalyzes the hydrolysis ofphosphatidylcholine, producing choline andphosphatidic acid; involved inSec14p-independent secretion; required formeiosis and spore formation; differentlyregulated in secretion and meiosis 0.092220.6662&radic&radic&radic&radic&radic&radic S000000781POL5YEL055CverifiedProtein with sequence similarity to the human MybBP1A and weaksequence similar to B-type DNA polymerases, notrequired for chromosomal DNA replication;required for the synthesis of rRNA &radic0.091860.66405&radic&radic&radic&radic S000004886ZDS1YMR273CverifiedProtein that interacts with silencing proteins at the telomere,involved in transcriptional silencing; has arole in localization of Bcy1p, a regulatorysubunit of protein kinase A; implicated in mRNAnuclear export 0.091330.66405&radic&radic&radic&radic S000000939YER137CUncharacterizedHypothetical protein 0.088050.65688&radic S000000440ABD1YBR236CverifiedMethyltransferase, catalyzes the transfer of a methyl groupfrom S-adenosylmethionine to the GpppN terminusof capped mRNA 0.088280.65688&radic&radic&radic S000006384AOS1YPR180WverifiedNuclear protein that acts as a heterodimer with Uba2p toactivate Smt3p (SUMO) before its conjugation toproteins (sumoylation), which may play a rolein protein targeting; essential for viability 0.085510.65229&radic&radic&radic S000005193MPA43YNL249CverifiedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.08610.65229&radic&radic&radic S000002495SLU7YDR088CverifiedRNA splicing factor, required for ATP-independent portion of2nd catalytic step of spliceosomal RNAsplicing; interacts with Prp18p; contains zincknuckle domain 0.084860.65093&radic&radic&radic S000000871ARG5,6YER069WverifiedProtein that is processed in the mitochondrion to yieldacetylglutamate kinase andN-acetyl-gamma-glutamyl-phosphate reductase,which catalyze the 2nd and 3rd steps inarginine biosynthesis; enzymes form a complexwith Arg2p &radic0.083170.64853&radic&radic&radic&radic S000001542MPE1YKL059CverifiedEssential conserved subunit of CPF (cleavage andpolyadenylation factor), plays a role in 3' endformation of mRNA via the specific cleavage andpolyadenylation of pre-mRNA, contains aputative RNA-binding zinc knuckle motif 0.082760.64603&radic&radic&radic S000002553SWI5YDR146CverifiedTranscription factor that activates transcription of genesexpressed at the M/G1 phase boundary and in G1phase; localization to the nucleus occursduring G1 and appears to be regulated byphosphorylation by Cdc28p kinase 0.08220.64603&radic&radic&radic S000006371MET16YPR167Cverified3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylylsulfate to adenosine-3',5'-bisphosphate andfree sulfite using reduced thioredoxin ascosubstrate, involved in sulfate assimilationand methionine metabolism 0.082420.64603&radic&radic S000001304PKP1YIL042CverifiedMitochondrial kinase, phosphorylates pyruvate dehydrogenasealpha subunit Pda1p &radic0.079240.64071&radic&radic S000001665FAS1YKL182WverifiedBeta subunit of fatty acid synthetase, which catalyzes thesynthesis of long-chain saturated fatty acids;contains acetyltransacylase, dehydratase, enoylreductase, malonyl transacylase, and palmitoyltransacylase activities 0.079630.64071&radic&radic&radic&radic S000001915FAB1YFR019Wverified1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membranekinase that generates phosphatidylinositol(3,5)P2, which is involved in vacuolar sortingand homeostasis &radic0.079020.64042&radic S000001295BCY1YIL033CverifiedRegulatory subunit of the cyclic AMP-dependent protein kinase(PKA), a component of a signaling pathway thatcontrols a variety of cellular processes,including metabolism, cell cycle, stressresponse, stationary phase, and sporulation 0.078770.63985&radic&radic&radic S000004802SGS1YMR190CverifiedNucleolar DNA helicase of the RecQ family involved inmaintenance of genome integrity, regulateschromosome synapsis and meiotic crossing over;has similarity to human BLM and WRN helicasesimplicated in Bloom and Werner syndromes 0.078030.63639&radic&radic&radic S000000909GLE2YER107CverifiedComponent of the nuclear pore complex required forpolyadenylated RNA export but not for proteinimport, homologous to S. pombe Rae1p 0.077090.63507&radic S000000288MIS1YBR084WverifiedMitochondrial C1-tetrahydrofolate synthase, involved ininterconversion between different oxidationstates of tetrahydrofolate (THF); providesactivities of formyl-THF synthetase,methenyl-THF cyclohydrolase, and methylene-THFdehydrogenase 0.076630.63483&radic S000004310EST2YLR318WverifiedReverse transcriptase subunit of the telomerase holoenzyme,essential for telomerase core catalyticactivity, involved in other aspects oftelomerase assembly and function; mutations inhuman homolog are associated with aplasticanemia &radic0.075990.63333 S000001170FUR1YHR128WverifiedUracil phosphoribosyltransferase, synthesizes UMP from uracil;involved in the pyrimidine salvage pathway 0.074490.62784&radic S000006156RVB2YPL235WverifiedEssential protein involved in transcription regulation;component of chromatin remodeling complexes;required for assembly and function of the INO80complex; member of the RUVB-like protein family 0.073190.62441&radic&radic S000003865SOD1YJR104CverifiedCytosolic superoxide dismutase; some mutations are analogous tothose that cause ALS (amyotrophic lateralsclerosis) in humans 0.072920.62441&radic&radic&radic S000001334HOP1YIL072WverifiedMeiosis-specific DNA binding protein that displays Red1pdependent localization to the unsynapsedaxial-lateral elements of the synaptonemalcomplex; required for homologous chromosomesynapsis and chiasma formation 0.072190.62306&radic S000005454RFC4YOL094CverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon 0.071340.62138&radic S000002216USO1YDL058WverifiedEssential protein involved in intracellular protein transport,coiled-coil protein necessary for transportfrom ER to Golgi; required for assembly of theER-to-Golgi SNARE complex 0.067920.61219&radic S000004574URA5YML106WverifiedOne of two orotate phosphoribosyltransferase isozymes (see alsoURA10) that catalyze the fifth enzymatic stepin de novo biosynthesis of pyrimidines,converting orotate into orotidine-5'-phosphate 0.068060.61219&radic&radic&radic S000000612MAK32YCR019WverifiedProtein necessary for structural stability of L-Adouble-stranded RNA-containing particles 0.065340.60277&radic&radic&radic S000000755BUD16YEL029CverifiedProtein involved in bud-site selection and telomeremaintenance; diploid mutants display a randombudding pattern instead of the wild-typebipolar pattern; has similarity to pyridoxalkinases 0.064060.59979&radic&radic&radic&radic&radic S000001756NAP1YKR048CverifiedProtein that interacts with mitotic cyclin Clb2p; required forthe regulation of microtubule dynamics duringmitosis; controls bud morphogenesis; involvedin the transport of H2A and H2B histones to thenucleus 0.06180.59215&radic&radic S000000632RBK1YCR036WverifiedPutative ribokinase &radic0.061570.59166&radic&radic&radic S000001217ENO2YHR174WverifiedEnolase II, a phosphopyruvate hydratase that catalyzes theconversion of 2-phosphoglycerate tophosphoenolpyruvate during glycolysis and thereverse reaction during gluconeogenesis;expression is induced in response to glucose 0.059810.58567&radic S000000870MOT2YER068WverifiedComponent of the CCR4-NOT complex, which has multiple roles intranscription regulation, mRNA degradation, andpost-transcriptional modifications; with Ubc4p,ubiquitylates subunits of the nascentpolypeptide-associated complex (NAC) 0.059550.58473&radic&radic&radic S000006217YPR013CUncharacterizedPutative zinc finger protein; YPR013C is not an essential gene 0.05810.58074 S000002536SAC6YDR129CverifiedFimbrin, actin-bundling protein; cooperates with Scp1p(calponin/transgelin) in the organization andmaintenance of the actin cytoskeleton 0.057770.57556&radic&radic S000002574TAF10YDR167WverifiedSubunit (145 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification 0.057220.57556&radic&radic&radic&radic S000004842RRP5YMR229CverifiedProtein required for the synthesis of both 18S and 5.8S rRNA;C-terminal region is crucial for the formationof 18S rRNA and N-terminal region is requiredfor the 5.8S rRNA; component of small ribosomalsubunit (SSU) processosome 0.055020.56692&radic&radic&radic S000001725YKR017CUncharacterizedPutative protein of unknown function; contains a RING finger motif 0.055430.56692&radic&radic S000001518UGP1YKL035WverifiedUDP-glucose pyrophosphorylase (UGPase), catalyses thereversible formation of UDP-Glc from glucose1-phosphate and UTP, involved in a wide varietyof metabolic pathways, expression modulated byPho85p through Pho4p &radic0.053970.56388&radic&radic&radic&radic&radic S000004061RGR1YLR071CverifiedComponent of RNA polymerase II holoenzyme/mediator complex;affects chromatin structure and transcriptionalregulation of diverse genes; required forglucose repression, HO repression, RME1repression and sporulation 0.053760.56129&radic&radic S000005527RRP6YOR001WverifiedExonuclease component of the nuclear exosome; contributes tothe quality-control system that retains anddegrades aberrant mRNAs in the nucleus 0.053410.56129&radic&radic S000004884URA10YMR271CverifiedOne of two orotate phosphoribosyltransferase isozymes (see alsoURA5) that catalyze the fifth enzymatic step inthe de novo biosynthesis of pyrimidines,converting orotate into orotidine-5'-phosphate 0.051770.55451&radic&radic S000002905ITR1YDR497CverifiedMyo-inositol transporter with strong similarity to the minormyo-inositol transporter Itr2p, member of thesugar transporter superfamily; expression isrepressed by inositol and choline via Opi1p andderepressed via Ino2p and Ino4p 0.051740.55451 S000002971CDH1YGL003CverifiedCell-cycle regulated activator of the anaphase-promotingcomplex/cyclosome (APC/C), which directsubiquitination of mitotic cyclins resulting inexit from mitosis; targets the APC/C tospecific substrates including CDC20, ASE1 andCIN8 0.051720.55451&radic S000005335POP2YNR052CverifiedRNase of the DEDD superfamily, subunit of the Ccr4-Not complexthat mediates 3' to 5' mRNA deadenylation 0.050620.5509&radic&radic&radic S000000004SSA1YAL005CverifiedATPase involved in protein folding and nuclear localizationsignal (NLS)-directed nuclear transport; memberof heat shock protein 70 (HSP70) family; formsa chaperone complex with Ydj1p; localized tothe nucleus, cytoplasm, and cell wall 0.050570.5509&radic&radic&radic S000001412MCM10YIL150CverifiedEssential, chromatin-associated protein involved in theinitiation of DNA replication; required for theassociation of the MCM2-7 complex withreplication origins 0.050610.5509&radic&radic S000001103GIC1YHR061CverifiedProtein of unknown function involved in initiation of buddingand cellular polarization, interacts withCdc42p via the Cdc42/Rac-interactive binding(CRIB) domain 0.050620.5509&radic&radic&radic&radic&radic&radic S000002849APT2YDR441CverifiedApparent pseudogene, not transcribed or translated under normalconditions; encodes a protein with similarityto adenine phosphoribosyltransferase, butartificially expressed protein exhibits noenzymatic activity 0.050980.5509&radic&radic S000004025MLH2YLR035CverifiedProtein required for DNA mismatch repair in mitosis andmeiosis; involved in the repair of mutationalintermediates; forms a complex with Pms1p andMsh1p to repair mismatched DNA 0.050070.54822&radic&radic S000002717GIC2YDR309CverifiedProtein of unknown function involved in initiation of buddingand cellular polarization, interacts withCdc42p via the Cdc42/Rac-interactive binding(CRIB) domain 0.050030.54822&radic&radic&radic&radic&radic S000002604YDR196CUncharacterizedpredicted to catalyze the final step in synthesis of Coenzyme A &radic0.04940.54517&radic&radic S000004173TOS4YLR183CverifiedTranscription factor that binds to a number of promoterregions, particularly promoters of some genesinvolved in pheromone response and cell cycle;potential Cdc28p substrate; expression isinduced in G1 by bound SBF 0.048130.53866&radic&radic&radic&radic S000000019CCR4YAL021CverifiedComponent of the CCR4-NOT transcriptional complex, which isinvolved in regulation of gene expression;component of the major cytoplasmic deadenylase,which is involved in mRNA poly(A) tailshortening 0.0480.53866&radic&radic&radic&radic S000002261QRI1YDL103CverifiedUDP-N-acetylglucosamine pyrophosphorylase, catalyzes theformation of UDP-N-acetylglucosamine(UDP-GlcNAc), which is important in cell wallbiosynthesis, protein N-glycosylation, and GPIanchor biosynthesis &radic0.048880.53866&radic&radic S000004615SEC59YMR013CverifiedDolichol kinase, catalyzes the terminal step in dolichylmonophosphate (Dol-P) biosynthesis; requiredfor viability and for normal rates of lipidintermediate synthesis and proteinN-glycosylation &radic0.047730.53775&radic&radic S000001505CDC16YKL022CverifiedSubunit of the anaphase-promoting complex/cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition; required forsporulation 0.047660.53775&radic&radic&radic&radic S000005226POP3YNL282WverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends 0.047540.53765&radic&radic&radic&radic&radic S000007262AI2Q0055verifiedReverse transcriptase required for splicing of the COX1pre-mRNA, encoded by a mobile group II intronwithin the mitochondrial COX1 gene &radic0.047540.53756 S000000515ILV6YCL009CverifiedRegulatory subunit of acetolactate synthase, which catalyzesthe first step of branched-chain amino acidbiosynthesis; enhances activity of the Ilv2pcatalytic subunit, localizes to mitochondria 0.047380.53464&radic&radic S000001537DEF1YKL054CverifiedRNAPII degradation factor, forms a complex with Rad26p inchromatin, enables ubiquitination andproteolysis of RNAPII present in an elongationcomplex 0.047130.53464&radic&radic&radic&radic&radic S000004915ADE4YMR300CverifiedPhosphoribosylpyrophosphate amidotransferase (PRPPAT;amidophosphoribosyltransferase), catalyzesfirst step of the 'de novo' purine nucleotidebiosynthetic pathway 0.046350.53277&radic&radic S000001528PRI2YKL045WverifiedSubunit of DNA primase, which is required for DNA synthesis anddouble-strand break repair &radic0.046330.53277&radic S000002565HOM2YDR158WverifiedAspartic beta semi-aldehyde dehydrogenase, catalyzes the secondstep in the common pathway for methionine andthreonine biosynthesis; expression regulated byGcn4p and the general control of amino acidsynthesis 0.045210.52774&radic&radic&radic&radic S000000845SAH1YER043CverifiedS-adenosyl-L-homocysteine hydrolase, catabolizesS-adenosyl-L-homocysteine which is formed afterdonation of the activated methyl group ofS-adenosyl-L-methionine (AdoMet) to an acceptor 0.045110.52717&radic&radic&radic&radic S000003693FAR1YJL157CverifiedCyclin-dependent kinase inhibitor that mediates cell cyclearrest in response to pheromone; also forms acomplex with Cdc24p, Ste4p, and Ste18p that mayspecify the direction of polarized growthduring mating; potential Cdc28p substrate 0.044410.52475&radic&radic&radic S000002789YRA1YDR381WverifiedNuclear protein that binds to RNA and to Mex67p, required forexport of poly(A)+ mRNA from the nucleus;member of the REF (RNA and export factorbinding proteins) family; another familymember, Yra2p, can substitute for Yra1pfunction 0.044320.52451&radic&radic&radic&radic&radic S000002625RAD9YDR217CverifiedDNA damage-dependent checkpoint protein, required forcell-cycle arrest in G1/S, intra-S, and G2/M;transmits checkpoint signal by activatingRad53p and Chk1p; hyperphosphorylated by Mec1pand Tel1p; potential Cdc28p substrate 0.044140.52068&radic&radic&radic S000004523SML1YML058WverifiedRibonucleotide reductase inhibitor involved in regulating dNTPproduction; regulated by Mec1p and Rad53pduring DNA damage and S phase 0.044160.52068&radic&radic&radic S000004121ACE2YLR131CverifiedTranscription factor that activates expression of earlyG1-specific genes, localizes to daughter cellnuclei after cytokinesis and delays G1progression in daughters, localization isregulated by phosphorylation; potential Cdc28psubstrate 0.043130.51832&radic&radic&radic&radic&radic S000001388STH1YIL126WverifiedATPase component of the ATP-dependent RSC chromatin remodelingcomplex required for kinetochore function inchromosome segregation; required for expressionof early meiotic genes; essentialhelicase-related protein homologous to Snf2p 0.042720.51704&radic S000003105SEC27YGL137WverifiedEssential beta'-coat protein of the COPI coatomer, involved inER-to-Golgi and Golgi-to-ER transport; containsWD40 domains that mediate cargo selectiveinteractions; 45% sequence identity tomammalian beta'-COP 0.04230.51435 S000002622AHA1YDR214WverifiedCo-chaperone that binds to Hsp82p and activates its ATPaseactivity; similar to Hch1p; expression isregulated by stresses such as heat shock 0.041490.5095&radic&radic&radic&radic S000000897RAD51YER095WverifiedStrand exchange protein, forms a helical filament with DNA thatsearches for homology; involved in therecombinational repair of double-strand breaksin DNA during vegetative growth and meiosis;homolog of Dmc1p and bacterial RecA protein 0.041320.5095&radic&radic S000000065RFA1YAR007CverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 0.041340.5095&radic&radic&radic&radic S000004069SIC1YLR079WverifiedInhibitor of Cdc28-Clb kinase complexes that controls G1/Sphase transition, preventing premature S phaseand ensuring genomic integrity; phosphorylationtargets Sic1p for SCF(CDC4)-dependent turnover;functional homolog of mammalian Kip1 0.040920.5023&radic&radic S000003913DAL5YJR152WverifiedAllantoin permease; ureidosuccinate permease; expression isconstitutive but sensitive to nitrogencatabolite repression 0.040110.5023 S000000927RSP5YER125WverifiedUbiquitin-protein ligase involved in ubiquitin-mediated proteindegradation; plays a role in heat shock element(HSE)-mediated gene expression andmultivesicular body sorting; contains a hect(homologous to E6-AP carboxyl terminus) domain 0.040110.5023&radic S000004099AHP1YLR109WverifiedThiol-specific peroxiredoxin, reduces hydroperoxides to protectagainst oxidative damage; function in vivorequires covalent conjugation to Urm1p 0.039840.50125&radic&radic&radic&radic S000003651ASF1YJL115WverifiedNucleosome assembly factor, involved in chromatin assembly anddisassembly, anti-silencing protein that causesderepression of silent loci when overexpressed 0.039780.50076&radic S000001185RPC10YHR143W-AverifiedRNA polymerase subunit, found in RNA polymerase complexes I,II, and III &radic0.038990.4971&radic&radic&radic&radic S000003730CDC6YJL194WverifiedEssential ATP-binding protein required for DNA replication,component of the pre-replicative complex(pre-RC) which requires ORC to associate withchromatin and is in turn required for Mcm2-7pDNA association; homologous to S. pombe Cdc18p 0.039510.4971&radic&radic&radic&radic S000002510STE5YDR103WverifiedPheromone-responsive scaffold protein; shuttles from thenucleus to the plasma membrane and assembleskinases Ste11p, Ste7p, and Fus3p into aspecific signaling complex; active oligomericform interacts with Ste4p-Ste18p complex 0.038750.49478&radic&radic&radic&radic S000004494RAD52YML032CverifiedProtein that stimulates strand exchange by facilitating Rad51pbinding to single-stranded DNA; annealscomplementary single-stranded DNA; involved inthe repair of double-strand breaks in DNAduring vegetative growth and meiosis 0.038860.49478&radic&radic&radic&radic S000005565CKB2YOR039WverifiedBeta' regulatory subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKA2 and CKB1, the many substratesinclude transcription factors and all RNApolymerases 0.038310.4892&radic&radic&radic&radic&radic S000006323CLB2YPR119WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the transition from G2 to Mphase; accumulates during G2 and M, thentargeted via a destruction box motif forubiquitin-mediated degradation by theproteasome 0.038030.4892&radic&radic&radic S000004683CTF18YMR078CverifiedSubunit of a complex with Ctf8p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion; may have overlappingfunctions with Rad24p in the DNA damagereplication checkpoint 0.038150.4892&radic&radic S000005859VMA4YOR332WverifiedSubunit E of the eight-subunit V1 peripheral membrane domain ofthe vacuolar H+-ATPase (V-ATPase), anelectrogenic proton pump found throughout theendomembrane system; required for the V1 domainto assemble onto the vacuolar membrane 0.038550.4892&radic&radic&radic S000004170SAM1YLR180WverifiedS-adenosylmethionine synthetase, catalyzes transfer of theadenosyl group of ATP to the sulfur atom ofmethionine; one of two differentially regulatedisozymes (Sam1p and Sam2p) 0.038020.4892&radic&radic&radic&radic&radic S000003246MSB2YGR014WverifiedMucin family member at the head of the Cdc42p- and MAPkinase-dependent filamentous growth signalingpathway; also functions as an osmosensor inparallel to the Sho1p-mediated pathway;potential Cdc28p substrate 0.037990.4892&radic S000002545HPR1YDR138WverifiedSubunit of THO/TREX complexes that couple transcriptionelongation with mitotic recombination and withmRNA metabolism and export, subunit of an RNAPol II complex; regulates lifespan; involved intelomere maintenance; similar to Top1p 0.037780.48881&radic&radic&radic S000004849TAF9YMR236WverifiedSubunit (17 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification, similar to histone H3 0.03770.48822&radic&radic S000000233CDS1YBR029CverifiedPhosphatidate cytidylyltransferase (CDP-diglyceridesynthetase); an enzyme that catalyzes thatconversion of CTP + phosphate into diphosphate+ CDP-diaclglyerol, a critical step in thesynthesis of all major yeast phospholipids &radic0.037720.48822 S000002534ARO1YDR127WverifiedPentafunctional arom protein, catalyzes steps 2 through 6 inthe biosynthesis of chorismate, which is aprecursor to aromatic amino acids &radic0.037460.48776&radic&radic&radic S000004334FKS1YLR342WverifiedCatalytic subunit of 1,3-beta-D-glucan synthase, functionallyredundant with alternate catalytic subunitGsc2p; binds to regulatory subunit Rho1p;involved in cell wall synthesis andmaintenance; localizes to sites of cell wallremodeling 0.03730.48417&radic&radic S000004812CLN1YMR199WverifiedG1 cyclin involved in regulation of the cell cycle; activatesCdc28p kinase to promote the G1 to S phasetransition; late G1 specific expression dependson transcription factor complexes, MBF(Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) 0.037280.48417&radic&radic&radic S000003957RIX7YLL034CverifiedPutative ATPase of the AAA family, required for export ofpre-ribosomal large subunits from the nucleus;distributed between the nucleolus, nucleoplasm,and nuclear periphery depending on growthconditions 0.037210.48417&radic&radic&radic S000000402TAF5YBR198CverifiedSubunit (90 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification 0.03720.48417&radic&radic S000001608RRN3YKL125WverifiedProtein required for transcription of rDNA by RNA polymerase I;transcription factor independent of DNAtemplate; involved in recruitment of RNApolymerase I to rDNA 0.037240.48417&radic&radic&radic&radic S000000520BUD3YCL014WverifiedProtein involved in bud-site selection and required for axialbudding pattern; localizes with septins to budneck in mitosis and may constitute an axiallandmark for next round of budding 0.036960.48417&radic&radic S000002504MSH6YDR097CverifiedProtein required for mismatch repair in mitosis and meiosis,forms a complex with Msh2p to repair bothsingle-base & insertion-deletion mispairs;potentially phosphorylated by Cdc28p 0.036910.48147&radic&radic&radic S000000973RAD3YER171Wverified5' to 3' DNA helicase, involved in nucleotide excision repairand transcription; subunit of RNA polymerase IItranscription initiation factor TFIIH; subunitof Nucleotide Excision Repair Factor 3 (NEF3);homolog of human XPD protein 0.036780.48147&radic&radic S000003666URA2YJL130CverifiedBifunctional carbamoylphosphate synthetase (CPSase)-aspartatetranscarbamylase (ATCase), catalyzes the firsttwo enzymatic steps in the de novo biosynthesisof pyrimidines; both activities are subject tofeedback inhibition by UTP 0.036350.4781&radic&radic&radic&radic S000003432ELP2YGR200CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;target of Kluyveromyces lactis zymocin 0.036360.4781&radic&radic&radic&radic S000005073NRK1YNL129WverifiedNicotinamide riboside kinase, catalyzes the synthesis ofnicotinamide nucleotide (NMN) from nicotinamideriboside; involved in a salvage pathway forNAD+ biosynthesis &radic0.036210.4781&radic&radic S000001587GFA1YKL104CverifiedGlutamine-fructose-6-phosphate amidotransferase, catalyzes theformation of glucosamine-6-P and glutamate fromfructose-6-P and glutamine in the first step ofchitin biosynthesis 0.036350.4781&radic&radic&radic S000005195NRD1YNL251CverifiedRNA-binding protein that interacts with the C-terminal domainof the RNA polymerase II large subunit(Rpo21p), required for transcriptiontermination and 3' end maturation ofnonpolyadenylated RNAs 0.036380.4781&radic&radic&radic S000000234YBR030WUncharacterizedHypothetical protein 0.036250.4781&radic S000002344TFP1YDL185WverifiedVacuolar ATPase V1 domain subunit A containing the catalyticnucleotide binding sites; protein precursorundergoes self-catalyzed splicing to yield theextein Tfp1p and the intein Vde (PI-SceI),which is a site-specific endonuclease 0.036250.4781&radic S000002563RPA14YDR156WverifiedRNA polymerase I subunit A14 &radic0.03610.47723&radic&radic&radic S000001400TPM2YIL138CverifiedMinor isoform of tropomyosin, binds to and stabilizes actincables and filaments, which direct polarizedcell growth and the distribution of severalorganelles; appears to have distinct and alsooverlapping functions with Tpm1p 0.036020.47679&radic&radic S000001083SRB2YHR041CverifiedGeneral transcription factor, subunit of the RNA polymerase IImediator complex; associates with corepolymerase subunits to form the RNA polymeraseII holoenzyme; involved in telomere maintenance 0.035640.47253&radic&radic&radic S000003055MMS2YGL087CverifiedProtein involved in error-free postreplication DNA repair;forms a heteromeric complex with Ubc13p thathas a ubiquitin-conjugating activity;cooperates with chromatin-associated RINGfinger proteins, Rad18p and Rad5p 0.035460.47253&radic&radic&radic&radic&radic S000004352VPS38YLR360WverifiedPart of a Vps34p phosphatidylinositol 3-kinase complex thatfunctions in carboxypeptidase Y (CPY) sorting;binds Vps30p and Vps34p to promote productionof phosphatidylinositol 3-phosphate (PtdIns3P)which stimulates kinase activity 0.034980.47015&radic S000005366TOP1YOL006CverifiedTopoisomerase I, nuclear enzyme that relieves torsional strainin DNA by cleaving and re-sealing thephosphodiester backbone; relaxes bothpositively and negatively supercoiled DNA;functions in replication, transcription, andrecombination 0.035110.47015&radic&radic&radic&radic S000005902GDH1YOR375CverifiedNADP(+)-dependent glutamate dehydrogenase, synthesizesglutamate from ammonia and alpha-ketoglutarate;rate of alpha-ketoglutarate utilization differsfrom Gdh3p; expression regulated by nitrogenand carbon sources 0.03510.47015&radic&radic&radic&radic S000002672AKR1YDR264CverifiedPalmitoyl transferase involved in protein palmitoylation; actsas a negative regulator of pheromone responsepathway; required for endocytosis of pheromonereceptors; involved in cell shape control;contains ankyrin repeats 0.035240.47015&radic&radic&radic&radic&radic S000000171SSA3YBL075CverifiedATPase involved in protein folding and the response to stress;plays a role in SRP-dependent cotranslationalprotein-membrane targeting and translocation;member of the heat shock protein 70 (HSP70)family; localized to the cytoplasm 0.034960.46973&radic&radic S000004484APT1YML022WverifiedAdenine phosphoribosyltransferase, catalyzes the formation ofAMP from adenine and5-phosphoribosylpyrophosphate; involved in thesalvage pathway of purine nucleotidebiosynthesis 0.034790.46956&radic&radic&radic S000006189PLC1YPL268WverifiedPhosphoinositide-specific phospholipase C, hydrolyzesphosphatidylinositol 4,5-biphosphate (PIP2) togenerate inositol 1,4,5-triphosphate (IP3) and1,2-diacylglycerol (DAG); involved inkinetochore function and pseudohyphaldifferentiation 0.034740.46825 S000001300NOT3YIL038CverifiedSubunit of the CCR4-NOT complex, which is a globaltranscriptional regulator with roles intranscription initiation and elongation and inmRNA degradation 0.034730.46825&radic S000004689YMR084WUncharacterizedHypothetical protein 0.034680.46825 S000001368MOB1YIL106WverifiedComponent of the mitotic exit network; associates with and isrequired for the activation andCdc15p-dependent phosphorylation of the Dbf2pkinase; required for cytokinesis and cellseparation; component of the CCR4transcriptional complex 0.034530.46526&radic&radic S000003389CHO2YGR157WverifiedPhosphatidylethanolamine methyltransferase (PEMT), catalyzesthe first step in the conversion ofphosphatidylethanolamine to phosphatidylcholineduring the methylation pathway ofphosphatidylcholine biosynthesis 0.034230.4644&radic&radic&radic&radic S000006177CLN2YPL256CverifiedG1 cyclin involved in regulation of the cell cycle; activatesCdc28p kinase to promote the G1 to S phasetransition; late G1 specific expression dependson transcription factor complexes, MBF(Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) 0.033960.46133&radic&radic&radic S000000337HSL7YBR133CverifiedProtein arginine N-methyltransferase that exhibits septin andHsl1p-dependent bud neck localization andperiodic Hsl1p-dependent phosphorylation;required along with Hsl1p for bud neckrecruitment, phosphorylation, and degradationof Swe1p 0.033930.46133&radic&radic S000002478PAA1YDR071CverifiedPolyamine acetyltransferase; acetylates polyamines (e.g.putrescine, spermidine, spermine) and alsoaralkylamines (e.g. tryptamine,phenylethylamine); may be involved intranscription and/or DNA replication 0.033960.46133&radic S000006276NOT5YPR072WverifiedSubunit of the CCR4-NOT complex, which is a globaltranscriptional regulator with roles intranscription initiation and elongation and inmRNA degradation 0.033940.46133&radic S000006230ATH1YPR026WverifiedAcid trehalase required for utilization of extracellulartrehalose 0.03340.45872 S000000824SRB4YER022WverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation 0.033250.45872&radic&radic&radic S000004034PDC1YLR044CverifiedMajor of three pyruvate decarboxylase isozymes, key enzyme inalcoholic fermentation, decarboxylates pyruvateto acetaldehyde; subject to glucose-, ethanol-,and autoregulation; involved in amino acidcatabolism 0.033310.45872&radic&radic&radic&radic&radic&radic S000005216SEC2YNL272CverifiedGuanyl-nucleotide exchange factor for the small G-proteinSec4p, located on cytoplasmic vesicles;essential for post-Golgi vesicle transport 0.03320.45819&radic&radic&radic&radic S000003684RPA34YJL148WverifiedRNA polymerase I subunit A34.5 &radic0.033110.45819&radic&radic S000001195SPO12YHR152WverifiedNucleolar protein of unknown function, positive regulator ofexit from mitosis; involved in regulating therelease of Cdc14p from the nucleolus in earlyanaphase; proposed to play similar role inmeiosis 0.032760.45535&radic&radic&radic&radic S000003080TAF6YGL112CverifiedSubunit (60 kDa) of TFIID and SAGA complexes, involved intranscription initiation of RNA polymerase IIand in chromatin modification, similar tohistone H4 0.032980.45535&radic S000002840NPL3YDR432WverifiedRNA-binding protein that carries poly(A)+ mRNA from the nucleusinto the cytoplasm; phosphorylation by Sky1p inthe cytoplasm may promote release of mRNAs 0.032830.45535&radic&radic&radic S000003674TIF2YJL138CverifiedTranslation initiation factor eIF4A, identical to Tif1p;DEA(D/H)-box RNA helicase that couples ATPaseactivity to RNA binding and unwinding; forms adumbbell structure of two compact domainsconnected by a linker; interacts with eIF4G 0.032860.45535&radic&radic&radic&radic S000001026SBP1YHL034CverifiedNucleolar single-strand nucleic acid binding protein;associates with small nuclear RNAs 0.032940.45535&radic&radic&radic&radic&radic S000004465GIS4YML006CverifiedCAAX box containing protein of unknown function, proposed to beinvolved in the RAS/cAMP signaling pathway 0.032670.45445&radic&radic&radic&radic S000000757SPF1YEL031WverifiedP-type ATPase, ion transporter of the ER membrane involved inER function and Ca2+ homeostasis; required forregulating Hmg2p degradation; conferssensitivity to a killer toxin (SMKT) producedby Pichia farinosa KK1 0.032670.45445&radic&radic&radic S000000742NPP2YEL016CverifiedNucleotide pyrophosphatase/phosphodiesterase family member;mediates extracellular nucleotide phosphatehydrolysis along with Npp1p and Pho5p; activityand expression enhanced during conditions ofphosphate starvation 0.032680.45445 S000003016RPT6YGL048CverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; bound byubiquitin-protein ligases Ubr1p and Ufd4p;localized mainly to the nucleus throughout thecell cycle 0.032750.45445&radic&radic&radic S000003163GCN1YGL195WverifiedPositive regulator of the Gcn2p kinase activity, forms acomplex with Gcn20p; proposed to stimulateGcn2p activation by an uncharged tRNA 0.032460.45226&radic&radic S000001100MED6YHR058CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation 0.03260.45226&radic&radic S000002648SNU56YDR240CverifiedComponent of U1 snRNP required for mRNA splicing viaspliceosome; yeast specific, no metazoancounterpart; interacts with mRNA in commitmentcomplex 0.032480.45226&radic&radic S000002701SSD1YDR293CverifiedProtein with a role in maintenance of cellular integrity,interacts with components of the TOR pathway;ssd1 mutant of a clinical S. cerevisiae straindisplays elevated virulence 0.032580.45226&radic&radic&radic&radic S000004187SIK1YLR197WverifiedEssential evolutionarily-conserved nucleolar protein componentof the box C/D snoRNP complexes that direct2'-O-methylation of pre-rRNA during itsmaturation; overexpression causes spindleorientation defects 0.032350.45133&radic&radic&radic S000004951LST8YNL006WverifiedProtein required for the transport of amino acid permease Gap1pfrom the Golgi to the cell surface; componentof the TOR signaling pathway; associates withboth Tor1p and Tor2p; contains a WD-repeat 0.032370.45133&radic S000000025YAL027WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YAL027W is a non-essential gene 0.032270.45097&radic&radic&radic S000003207CSE1YGL238WverifiedNuclear envelope protein that mediates the nuclear export ofimportin alpha (Srp1p), homolog of metazoan CASprotein, required for accurate chromosomesegregation 0.032120.44971&radic&radic&radic&radic S000005450MSH2YOL090WverifiedProtein that forms heterodimers with Msh3p and Msh6p that bindto DNA mismatches to initiate the mismatchrepair process; contains a Walker ATP-bindingmotif required for repair activity; Msh2p-Msh6pbinds to and hydrolyzes ATP 0.032170.44971&radic&radic S000004843RPS10BYMR230WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps10Ap and has similarity to ratribosomal protein S10 0.032150.44971&radic&radic&radic&radic S000003336SRB5YGR104CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation; involved intelomere maintenance 0.031910.44724&radic&radic&radic&radic S000005662IDH2YOR136WverifiedSubunit of mitochondrial NAD(+)-dependent isocitratedehydrogenase, which catalyzes the oxidation ofisocitrate to alpha-ketoglutarate in the TCAcycle 0.032060.44724&radic&radic S000004564TAF13YML098WverifiedTFIID subunit (19 kDa), involved in RNA polymerase IItranscription initiation, similar to histone H4with atypical histone fold motif of Spt3-liketranscription factors 0.032030.44724&radic&radic S000006367TIF3YPR163CverifiedTranslation initiation factor eIF-4B, has RNA annealingactivity; contains an RNA recognition motif andbinds to single-stranded RNA 0.031870.44724&radic&radic&radic&radic S000001239UTP9YHR196WverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.0320.44724&radic&radic S000003003MIG1YGL035CverifiedTranscription factor involved in glucose repression; C2H2 zincfinger protein similar to mammalian Egr andWilms tumor proteins 0.032080.44724&radic&radic&radic S000003738YJL202CDubiousHypothetical protein; open reading frame overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex 0.032060.44724&radic S000004557PRE8YML092Cverified20S proteasome beta-type subunit 0.031890.44724&radic S000001905GCN20YFR009WverifiedPositive regulator of the Gcn2p kinase activity, forms acomplex with Gcn1p; proposed to stimulate Gcn2pactivation by an uncharged tRNA 0.031990.44724&radic&radic&radic S000002457TPI1YDR050CverifiedTriose phosphate isomerase, abundant glycolytic enzyme; mRNAhalf-life is regulated by iron availability;transcription is controlled by activatorsReb1p, Gcr1p, and Rap1p through binding sitesin the 5' non-coding region 0.031910.44724&radic&radic&radic S000003586MTR4YJL050WverifiedDead-box family ATP dependent helicase required for mRNA exportfrom the nucleus; co-factor of the exosomecomplex, required for 3' end formation of 5.8SrRNA 0.031850.44643&radic S000000935GLC7YER133WverifiedCatalytic subunit of type 1 serine/threonine proteinphosphatase, involved in many processesincluding glycogen metabolism, sporulation, andmitosis; interacts with multiple regulatorysubunits; predominantly isolated with Sds22p 0.031830.44643&radic&radic S000003949HSP104YLL026WverifiedHeat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p(Hsp70) to refold and reactivate previouslydenatured, aggregated proteins; responsive tostresses including: heat, ethanol, and sodiumarsenite; involved in [PSI+] propagation 0.031590.44444&radic&radic&radic S000003466YHB1YGR234WverifiedNitric oxide oxidoreductase, flavohemoglobin involved in nitricoxide detoxification; plays a role in theoxidative and nitrosative stress responses 0.031680.44444&radic&radic&radic&radic S000003326VAS1YGR094WverifiedMitochondrial and cytoplasmic valyl-tRNA synthetase 0.031790.44444&radic&radic&radic&radic&radic S000002620TCP1YDR212WverifiedAlpha subunit of chaperonin-containing T-complex, whichmediates protein folding in the cytosol;involved in maintenance of actin cytoskeleton;homolog to Drosophila melanogaster and mousetailless complex polypeptide 0.031660.44444&radic&radic&radic&radic S000004022RAD5YLR032WverifiedSingle-stranded DNA-dependent ATPase, involved inpostreplication repair; contains RING fingerdomain 0.03160.44444&radic&radic S000001871BUD27YFL023WverifiedProtein involved in bud-site selection, nutrient signaling, andgene expression controlled by the TOR kinase;diploid mutants display a random buddingpattern instead of the wild-type bipolarpattern 0.031690.44444&radic&radic&radic&radic S000005670ELG1YOR144CverifiedProtein required for S phase progression and telomerehomeostasis, forms an alternative replicationfactor C complex important for DNA replicationand genome integrity; involved in homologousrecombination-mediated DNA repair 0.031710.44444&radic&radic&radic&radic S000003704SET2YJL168CverifiedHistone methyltransferase with a role in transcriptionalelongation, methylates a lysine residue ofhistone H3; associates with the C-terminaldomain of Rpo21p; histone methylation activityis regulated by phosphorylation status ofRpo21p 0.031450.43818&radic&radic&radic S000003951TPO1YLL028WverifiedPolyamine transporter that recognizes spermine, putrescine, andspermidine; catalyzes uptake of polyamines atalkaline pH and excretion at acidic pH;phosphorylation enhances activity and sortingto the plasma membrane 0.031430.43818&radic&radic&radic S000005738STE4YOR212WverifiedG protein beta subunit, forms a dimer with Ste18p to activatethe mating signaling pathway, forms aheterotrimer with Gpa1p and Ste18p to dampensignaling; may recruit Rho1p to the polarizedgrowth site during mating; contains WD40repeats 0.031180.43818&radic&radic S000003563RNR2YJL026WverifiedRibonucleotide-diphosphate reductase (RNR), small subunit; theRNR complex catalyzes the rate-limiting step indNTP synthesis and is regulated by DNAreplication and DNA damage checkpoint pathwaysvia localization of the small subunits 0.031450.43818&radic&radic&radic&radic&radic&radic S000004814RAD14YMR201CverifiedProtein that recognizes and binds damaged DNA during nucleotideexcision repair; subunit of Nucleotide ExcisionRepair Factor 1 (NEF1); contains zinc fingermotif; homolog of human XPA protein 0.031140.43818&radic&radic&radic S000000037CYC3YAL039CverifiedCytochrome c heme lyase (holocytochrome c synthase), attachesheme to apo-Cyc1p in the mitochondrialintermembrane space; human ortholog may have arole in microphthalmia with linear skin defects(MLS) 0.031040.43818&radic&radic&radic&radic S000000881YER079WUncharacterizedHypothetical protein 0.031390.43818&radic&radic&radic&radic&radic S000000566MRC1YCL061CverifiedS-phase checkpoint protein found at replication forks, requiredfor DNA replication; also required for Rad53pactivation during DNA replication stress, whereit forms a replication-pausing complex withTof1p and is phosphorylated by Mec1p; proteininvolved in replication checkpoint 0.031280.43818&radic&radic&radic&radic&radic S000004529TEM1YML064CverifiedGTP-binding protein of the ras superfamily involved intermination of M-phase; controls actomyosin andseptin dynamics during cytokinesis 0.031160.43818 S000000913SWI4YER111CverifiedDNA binding component of the SBF complex (Swi4p-Swi6p), atranscriptional activator that in concert withMBF (Mbp1-Swi6p) regulates late G1-specifictranscription of targets including cyclins andgenes required for DNA synthesis and repair 0.030530.43358&radic&radic S000000471REI1YBR267WverifiedCytoplasmic pre-60S factor; required for the correct recyclingof shuttling factors Alb1, Arx1 and Tif6 at theend of the ribosomal large subunit biogenesis;involved in bud growth in the mitotic signalingnetwork 0.030830.43358&radic&radic&radic&radic&radic S000005215BNI1YNL271CverifiedFormin, nucleates the formation of linear actin filaments,involved in cell processes such as budding andmitotic spindle orientation which require theformation of polarized actin cables,functionally redundant with BNR1 0.030530.43358&radic&radic&radic&radic S000001149CDC12YHR107CverifiedComponent of the septin ring of the mother-bud neck that isrequired for cytokinesis; septins recruitproteins to the neck and can act as a barrierto diffusion at the membrane, and they comprisethe 10nm filaments seen with EM 0.030660.43358&radic S000003778ESS1YJR017CverifiedPeptidylprolyl-cis/trans-isomerase (PPIase) specific forphosphorylated serine and threonine residuesN-terminal to proline; regulatesphosphorylation of the RNA polymerase II largesubunit (Rpo21p) C-terminal domain 0.030750.43358&radic&radic&radic S000004684SEC14YMR079WverifiedPhosphatidylinositol/phosphatidylcholine transfer proteininvolved in coordinate regulation of PtdIns andPtdCho metabolism, products of which areregulators in Golgi to plasma membranetransport; functionally homologous to mammalianPITPs 0.030620.43358&radic&radic&radic S000000189ROX3YBL093CverifiedRNA polymerase II holoenzyme component 0.030650.43358&radic&radic&radic S000002632HTB1YDR224CverifiedOne of two nearly identical (see HTB2) histone H2B subtypesrequired for chromatin assembly and chromosomefunction; Rad6p-Bre1p-Lge1p mediatedubiquitination regulates transcriptionalactivation, meiotic DSB formation and H3methylation 0.030610.43358&radic&radic&radic S000002615UME6YDR207CverifiedKey transcriptional regulator of early meiotic genes, bindsURS1 upstream regulatory sequence, couplesmetabolic responses to nutritional cues withinitiation and progression of meiosis, formscomplex with Ime1p, and also with Sin3p-Rpd3p 0.030970.43358&radic&radic&radic&radic S000004924GAS1YMR307WverifiedBeta-1.3-glucanosyltransferase, required for cell wallassembly; localizes to the cell surface via aglycosylphosphatidylinositol (GPI) anchor 0.030810.43358&radic&radic&radic&radic&radic S000004490TSA1YML028WverifiedUbiquitous housekeeping thioredoxin peroxidase, reducesreactive oxygen, nitrogen and sulfur speciesusing thioredoxin as hydrogen donor; mediatesredox regulation of the nuclear localization ofYap1p; deletion results in mutator phenotype 0.030450.43126&radic&radic&radic&radic S000002764SPC110YDR356WverifiedInner plaque spindle pole body (SPB) component, ortholog ofhuman kendrin; involved in connecting nuclearmicrotubules to SPB; interacts withTub4p-complex and calmodulin; phosphorylated byMps1p in cell cycle-dependent manner 0.030430.43126&radic&radic S000005194RAD50YNL250WverifiedSubunit of MRX complex, with Mre11p and Xrs2p, involved inprocessing double-strand DNA breaks invegetative cells, initiation of meiotic DSBs,telomere maintenance, and nonhomologous endjoining 0.030440.43126&radic&radic S000000122LSM2YBL026WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.030270.43126&radic&radic&radic S000000975RAD24YER173WverifiedCheckpoint protein, involved in the activation of the DNAdamage and meiotic pachytene checkpoints;subunit of a clamp loader that loadsRad17p-Mec3p-Ddc1p onto DNA; homolog of humanand S. pombe Rad17 protein 0.030230.43126&radic&radic S000002217RAD59YDL059CverifiedProtein involved in the repair of double-strand breaks in DNAduring vegetative growth via recombination andsingle-strand annealing; anneals complementarysingle-stranded DNA; homologous to Rad52p 0.030210.43094&radic&radic&radic S000000292POL30YBR088CverifiedProliferating cell nuclear antigen (PCNA), functions as thesliding clamp for DNA polymerase delta; mayfunction as a docking site for other proteinsrequired for mitotic and meiotic chromosomalDNA replication and for DNA repair &radic0.030210.43094&radic&radic S000000033FUN12YAL035WverifiedGTPase, required for general translation initiation bypromoting Met-tRNAiMet binding to ribosomes andribosomal subunit joining; homolog of bacterialIF2 0.029860.42704&radic&radic&radic S000000884UTP7YER082CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.030010.42704&radic&radic S000005660BAG7YOR134WverifiedRho GTPase activating protein (RhoGAP), stimulates theintrinsic GTPase activity of Rho1p, which playsa role in actin cytoskeleton organization andcontrol of cell wall synthesis; structurallyand functionally related to Sac7p 0.030020.42704&radic S000000537STE50YCL032WverifiedProtein involved in mating response, invasive/filamentousgrowth, and osmotolerance, acts as an adaptorthat links G protein-associated Cdc42p-Ste20pcomplex to the effector Ste11p to modulatesignal transduction 0.02990.42704&radic&radic&radic S000005786GCD1YOR260WverifiedGamma subunit of the translation initiation factor eIF2B, theguanine-nucleotide exchange factor for eIF2;activity subsequently regulated byphosphorylated eIF2; first identified as anegative regulator of GCN4 expression 0.030080.42704&radic&radic&radic&radic S000004049REX2YLR059CverifiedRNA exonuclease, required for U4 snRNA maturation; functionsredundantly with Rnh70p in 5.8S rRNAmaturation, and with Rnh70p and Rex3p inprocessing of U5 snRNA and RNase P RNA; memberof RNase D family of exonucleases 0.030180.42704&radic&radic&radic&radic S000003084CDC20YGL116WverifiedCell-cycle regulated activator of anaphase-promotingcomplex/cyclosome (APC/C), which is requiredfor metaphase/anaphase transition; directsubiquitination of mitotic cyclins, Pds1p, andother anaphase inhibitors; potential Cdc28psubstrate 0.030120.42704&radic&radic S000005438AVO1YOL078WverifiedComponent of a membrane-bound complex containing the Tor2pkinase and other proteins, which may have arole in regulation of cell growth 0.029890.42704 S000003767SUI2YJR007WverifiedAlpha subunit of the translation initiation factor eIF2,involved in the identification of the startcodon; phosphorylation of Ser51 is required forregulation of translation by inhibiting theexchange of GDP for GTP 0.029960.42704&radic&radic S000002583NGG1YDR176WverifiedTranscriptional regulator involved in glucose repression ofGal4p-regulated genes; component oftranscriptional adaptor and histoneacetyltransferase complexes, the ADA complex,the SAGA complex, and the SLIK complex 0.030090.42704&radic&radic&radic&radic&radic S000005042RAS2YNL098CverifiedGTP-binding protein that regulates the nitrogen starvationresponse, sporulation, and filamentous growth;farnesylation and palmitoylation required foractivity and localization to plasma membrane;homolog of mammalian Ras proto-oncogenes 0.029840.42636&radic&radic&radic S000004239YEF3YLR249WverifiedTranslational elongation factor, stimulates the binding ofaminoacyl-tRNA (AA-tRNA) to ribosomes byreleasing EF-1 alpha from the ribosomalcomplex; contains two ABC cassettes; binds andhydrolyses ATP 0.029830.42636&radic&radic&radic&radic&radic S000000457SRB6YBR253WverifiedEssentital subunit of the RNA polymerase II mediator complex;associates with core polymerase subunits toform the RNA polymerase II holoenzyme;essential for transcriptional regulation 0.029780.42578&radic&radic&radic&radic&radic&radic S000003027YGL059WUncharacterizedHypothetical protein &radic0.029790.42578&radic S000001119NMD2YHR077CverifiedProtein involved in the nonsense-mediated mRNA decay (NMD)pathway; interacts with Nam7p and Upf3p;involved in telomere maintenance 0.029780.42578&radic&radic&radic S000002432RPS11AYDR025WverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps11Bp and has similarity to E.coli S17 and rat S11 ribosomal proteins 0.029630.42488&radic&radic S000002520PDS1YDR113CverifiedSecurin that inhibits anaphase by binding separin Esp1p, alsoblocks cyclin destruction and mitotic exit,essential for cell cycle arrest in mitosis inthe presence of DNA damage or aberrant mitoticspindles; also present in meiotic nuclei 0.029450.42256&radic&radic S000001610PGM1YKL127WverifiedPhosphoglucomutase, minor isoform; catalyzes the conversionfrom glucose-1-phosphate toglucose-6-phosphate, which is a key step inhexose metabolism 0.029350.42256&radic&radic&radic S000003628HPR5YJL092WverifiedDNA helicase and DNA-dependent ATPase involved in DNA repair,required for proper timing of commitment tomeiotic recombination and the transition fromMeiosis I to Meiosis II; potential Cdc28psubstrate 0.029270.42256&radic S000001069RPN1YHR027CverifiedNon-ATPase base subunit of the 19S regulatory particle of the26S proteasome; may participate in therecognition of several ligands of theproteasome; contains a leucine-rich repeat(LRR) domain, a site for protein?proteininteractions 0.029470.42256&radic&radic&radic S000005700MED4YOR174WverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation 0.029440.42256&radic&radic&radic S000004920UBP15YMR304WverifiedUbiquitin-specific protease that may play a role in ubiquitinprecursor processing 0.029310.42256&radic&radic&radic&radic&radic&radic S000000950SPT15YER148WverifiedTATA-binding protein, general transcription factor thatinteracts with other factors to form thepreinitiation complex at promoters, essentialfor viability 0.02940.42256&radic S000005174ELA1YNL230CverifiedElongin A, F-box protein that forms a heterodimer with Elc1pand participates in transcription elongation 0.029250.42195&radic&radic&radic&radic&radic&radic S000002636PCF11YDR228CverifiedmRNA 3' end processing factor, essential component of cleavageand polyadenylation factor IA (CF IA), involvedin pre-mRNA 3' end processing and intranscription termination; binds C-terminaldomain of largest subunit of RNA pol II(Rpo21p) 0.029170.41984&radic&radic&radic&radic&radic S000002506BMH2YDR099Wverified14-3-3 protein, minor isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others 0.029140.41984&radic&radic S000002743MSN5YDR335WverifiedKaryopherin involved in nuclear import and export; shown to beresponsible for nuclear import of replicationprotein A and for export of several proteinsincluding Swi6p, Far1p, and Pho4p; cargodissociation involves binding to RanGTP 0.029090.41984&radic&radic&radic&radic&radic&radic&radic S000002499UBC13YDR092WverifiedUbiquitin-conjugating enzyme involved in the error-free DNApostreplication repair pathway; interacts withMms2p to assemble ubiquitin chains at the UbLys-63 residue; DNA damage triggersredistribution from the cytoplasm to thenucleus 0.029130.41984&radic&radic S000000602RVS161YCR009CverifiedAmphiphysin-like lipid raft protein; subunit of a complex(Rvs161p-Rvs167p) that regulates polarizationof the actin cytoskeleton, endocytosis, cellpolarity, cell fusion and viability followingstarvation or osmotic stress 0.029110.41984&radic&radic S000004311BUD6YLR319CverifiedActin- and formin-interacting protein, involved in actin cablenucleation and polarized cell growth; isolatedas bipolar budding mutant; potential Cdc28psubstrate 0.029050.41984&radic&radic S000000287TEC1YBR083WverifiedTranscription factor required for full Ty1 epxression,Ty1-mediated gene activation, and haploidinvasive and diploid pseudohyphal growth;TEA/ATTS DNA-binding domain family member 0.029150.41984&radic&radic S000003813RAD7YJR052WverifiedProtein that recognizes and binds damaged DNA in anATP-dependent manner (with Rad16p) duringnucleotide excision repair; subunit ofNucleotide Excision Repair Factor 4 (NEF4) 0.028440.41274&radic&radic S000003026RAD6YGL058WverifiedUbiquitin-conjugating enzyme (E2), involved in postreplicationrepair (with Rad18p), sporulation, telomeresilencing, and ubiquitin-mediated N-end ruleprotein degradation (with Ubr1p) 0.028750.41274&radic&radic&radic&radic S000002569NBP2YDR162CverifiedProtein involved in the HOG (high osmolarity glycerol) pathway,negatively regulates Hog1p by recruitment ofphosphatase Ptc1p the Pbs2p-Hog1p complex,found in the nucleus and cytoplasm, contains anSH3 domain that binds Pbs2p 0.028520.41274&radic&radic&radic S000000069BUD14YAR014CverifiedProtein involved in bud-site selection, Bud14p-Glc7p complexfunctions as a cortical regulator of dynein;diploid mutants display a random buddingpattern instead of the wild-type bipolarpattern 0.028930.41274&radic&radic&radic&radic S000002285PCL2YDL127WverifiedG1 cyclin, associates with Pho85p cyclin-dependent kinase (Cdk)to contribute to entry into the mitotic cellcycle, essential for cell morphogenesis;localizes to sites of polarized cell growth 0.028640.41274 S000001029YHL037CDubiousHypothetical protein 0.028550.41274&radic&radic&radic&radic S000002459DBF4YDR052CverifiedRegulatory subunit of Cdc7p-Dbf4p kinase complex, required forCdc7p kinase activity and initiation of DNAreplication; phosphorylates the Mcm2-7 familyof proteins; cell cycle regulated 0.028690.41274&radic&radic&radic&radic S000001930PHO4YFR034CverifiedBasic helix-loop-helix (bHLH) transcription factor; bindscooperatively with Pho2p to the PHO5 promoter;function is regulated by phosphorylation atmultiple sites and by phosphate availability 0.028630.41274&radic&radic&radic&radic&radic S000002796RVS167YDR388WverifiedActin-associated protein, subunit of a complex(Rvs161p-Rvs167p) involved in regulation ofactin cytoskeleton, endocytosis, and viabilityfollowing starvation or osmotic stress; homologof mammalian amphiphysin 0.028460.41274&radic S000005831ISW2YOR304WverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPasecomponent that, with Itc1p, forms a complexrequired for repression of a-specific genes,INO1, and early meiotic genes during mitoticgrowth 0.028480.41274&radic&radic S000004836UBP8YMR223WverifiedUbiquitin-specific protease that is a component of the SAGA(Spt-Ada-Gcn5-Acetyltransferase) acetylationcomplex; required for SAGA-mediateddeubiquitination of histone H2B 0.028460.41274&radic&radic&radic&radic S000005180SIN4YNL236WverifiedSubunit of the Mediator complex; interacts with the RNApolymerase II holoenzyme to postively ornegatively regulate transcription; dispensiblefor basal transcription 0.029030.41274&radic&radic S000000339CKS1YBR135WverifiedSubunit of the Cdc28 protein kinase, required for mitoticproteolysis, may also be involved in theproteolysis of the G1 cyclins 0.028820.41274&radic&radic&radic S000003450CRM1YGR218WverifiedMajor karyopherin, involved in export of proteins, RNAs, andribosomal subunits from the nucleus 0.02880.41274&radic&radic&radic&radic&radic S000003461SMI1YGR229CverifiedProtein involved in the regulation of cell wall synthesis;proposed to be involved in coordinating cellcycle progression with cell wall integrity 0.028510.41274&radic&radic&radic&radic S000002552TAF12YDR145WverifiedSubunit (61/68 kDa) of TFIID and SAGA complexes, involved inRNA polymerase II transcription initiation andin chromatin modification, similar to histoneH2A 0.028620.41274&radic&radic&radic S000000621NPP1YCR026CverifiedNucleotide pyrophosphatase/phosphodiesterase family member;mediates extracellular nucleotide phosphatehydrolysis along with Npp2p and Pho5p; activityand expression enhanced during conditions ofphosphate starvation 0.028860.41274 S000001055ARD1YHR013CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.028840.41274&radic&radic&radic&radic S000005593ALG8YOR067CverifiedGlucosyl transferase, involved in N-linked glycosylation; addsglucose to the dolichol-linked oligosaccharideprecursor prior to transfer to protein duringlipid-linked oligosaccharide biosynthesis;similar to Alg6p 0.0290.41274&radic&radic&radic S000001857TUB2YFL037WverifiedBeta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p)to form tubulin dimer, which polymerizes toform microtubules 0.028310.41114&radic&radic&radic S000005809YOR283WUncharacterizedPutative protein of unknown function with some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene 0.028360.41114&radic&radic&radic S000000400PGI1YBR196CverifiedGlycolytic enzyme phosphoglucose isomerase, catalyzes theinterconversion of glucose-6-phosphate andfructose-6-phosphate; required for cell cycleprogression and completion of the gluconeogenicevents of sporulation 0.028320.41114&radic&radic&radic S000006169GAL4YPL248CverifiedDNA-binding transcription factor required for the activation ofthe GAL genes in response to galactose;repressed by Gal80p and activated by Gal3p 0.028250.41114&radic S000005256RFA2YNL312WverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 0.028360.41114&radic&radic&radic&radic&radic&radic S000001259IMD2YHR216WverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, expression is induced bymycophenolic acid resulting in resistance tothe drug, expression is repressed by nutrientlimitation 0.028340.41114&radic&radic S000002379CDC13YDL220CverifiedSingle stranded DNA-binding protein found at TG1-3 telomereG-tails; regulates telomere replication throughrecruitment of specific sub-complexes, but theessential function is telomere capping 0.028370.41114&radic&radic S000002918SMT3YDR510WverifiedUbiquitin-like protein of the SUMO family, conjugated to lysineresidues of target proteins; regulateschromatid cohesion, chromosome segregation,APC-mediated proteolysis, DNA replication andseptin ring dynamics 0.028130.40701&radic&radic S000004279MEC3YLR288CverifiedDNA damage and meiotic pachytene checkpoint protein; subunit ofa heterotrimeric complex (Rad17p-Mec3p-Ddc1p)that forms a sliding clamp, loaded onto partialduplex DNA by a clamp loader complex; homologof human and S. pombe Hus1 0.027960.40701&radic S000000934PMD1YER132CverifiedProtein with an N-terminal kelch-like domain, putative negativeregulator of early meiotic gene expression;required, with Mds3p, for growth under alkalineconditions 0.027940.40701&radic S000005755WTM2YOR229WverifiedTranscriptional repressor involved in regulation of meiosis andsilencing; contains WD repeats 0.028030.40701&radic&radic&radic&radic S000004635HOF1YMR032WverifiedBud neck-localized, SH3 domain-containing protein required forcytokinesis; regulates actomyosin ring dynamicsand septin localization; interacts with theformins, Bni1p and Bnr1p, and with Cyk3p,Vrp1p, and Bni5p 0.027990.40701&radic&radic&radic&radic S000000638TAF2YCR042CverifiedTFIID subunit (150 kDa), involved in RNA polymerase IItranscription initiation 0.02810.40701&radic S000000976GRX4YER174CverifiedHydroperoxide and superoxide-radical responsiveglutathione-dependent oxidoreductase; monothiolglutaredoxin subfamily member along with Grx3pand Grx5p; protects cells from oxidative damage 0.027880.40701&radic&radic S000005627RAS1YOR101WverifiedGTPase involved in G-protein signaling in the adenylate cyclaseactivating pathway, plays a role in cellproliferation; localized to the plasmamembrane; homolog of mammalian RASproto-oncogenes 0.027910.40701&radic&radic&radic S000001746KAE1YKR038CverifiedPutative glycoprotease proposed to be in transcription as acomponent of the EKC protein complex withBud32p, Cgi121p, Pcc1p, and Gon7p; alsoidentified as a component of the KEOPS proteincomplex 0.027820.40701&radic&radic&radic S000005775APC5YOR249CverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 0.027840.40701&radic&radic&radic S000005534SLG1YOR008CverifiedSensor-transducer of the stress-activated PKC1-MPK1 kinasepathway involved in maintenance of cell wallintegrity; involved in organization of theactin cytoskeleton; secretory pathway Wsc1p isrequired for the arrest of secretion response 0.02780.40701&radic S000000944MAG1YER142Cverified3-methyl-adenine DNA glycosylase involved in protecting DNAagainst alkylating agents; initiates baseexcision repair by removing damaged bases tocreate abasic sites that are subsequentlyrepaired 0.028140.40701&radic&radic S000006054RDS2YPL133CverifiedZinc cluster protein involved in conferring resistance toketoconazole 0.028140.40701&radic S000006324CLB5YPR120CverifiedB-type cyclin involved in DNA replication during S phase;activates Cdc28p to promote initiation of DNAsynthesis; functions in formation of mitoticspindles along with Clb3p and Clb4p; mostabundant during late G1 phase 0.028160.40701&radic&radic S000003073ARC1YGL105WverifiedProtein that binds tRNA and methionyl- and glutamyl-tRNAsynthetases (Mes1p and Gus1p), delivering tRNAto them, stimulating catalysis, and ensuringtheir localization to the cytoplasm; also bindsquadruplex nucleic acids 0.027780.406&radic S000004165CBF5YLR175WverifiedPseudouridine synthase catalytic subunit of box H/ACA smallnucleolar ribonucleoprotein particles(snoRNPs), acts on both large and small rRNAsand on snRNA U2 0.027720.406&radic&radic&radic S000004607TAF4YMR005WverifiedTFIID subunit (48 kDa), involved in RNA polymerase IItranscription initiation; potential Cdc28psubstrate 0.027690.406 S000001126STE12YHR084WverifiedTranscription factor that is activated by a MAP kinasesignaling cascade, activates genes involved inmating or pseudohyphal/invasive growthpathways; cooperates with Tec1p transcriptionfactor to regulate genes specific for invasivegrowth 0.027620.40539&radic S000000964RAD4YER162CverifiedProtein that recognizes and binds damaged DNA (with Rad23p)during nucleotide excision repair; subunit ofNuclear Excision Repair Factor 2 (NEF2);homolog of human XPC protein 0.027630.40539&radic&radic S000004560RAD10YML095CverifiedSingle-stranded DNA endonuclease (with Rad1p), cleavessingle-stranded DNA during nucleotide excisionrepair and double-strand break repair; subunitof Nucleotide Excision Repair Factor 1 (NEF1);homolog of human ERCC1 protein 0.027580.40479&radic&radic S000004539FPR3YML074CverifiedNucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506binding protein; phosphorylated by caseinkinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) anddephosphorylated by Ptp1p 0.02760.40479&radic S000004410CDC73YLR418CverifiedConstituent of Paf1 complex with RNA polymerase II, Paf1p,Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinctfrom Srb-containing Pol II complexes; requiredfor expression of certain genes, modificationof some histones, and telomere maintenance 0.027540.40379&radic&radic S000001564TEF4YKL081WverifiedTranslation elongation factor EF-1 gamma 0.027480.40379&radic&radic&radic S000000891PTC2YER089CverifiedType 2C protein phosphatase; dephosphorylates Hog1p to limitmaximal osmostress induced kinase activity;dephosphorylates Ire1p to downregulate theunfolded protein response; dephosphorylatesCdc28p; role in DNA checkpoint inactivation 0.027460.40324&radic&radic&radic S000006112YPL191CUncharacterizedHypothetical protein 0.027470.40324&radic&radic&radic&radic&radic S000006115DDC1YPL194WverifiedDNA damage checkpoint protein, part of a PCNA-like complexrequired for DNA damage response, required forpachytene checkpoint to inhibit cell cycle inresponse to unrepaired recombinationintermediates; potential Cdc28p substrate 0.027460.40324&radic&radic S000003833NPA3YJR072CverifiedEssential, conserved, cytoplasmic ATPase; phosphorylated by thePcl1p-Pho85p kinase complex 0.027410.40247&radic&radic S000004466YAP1YML007WverifiedBasic leucine zipper (bZIP) transcription factor required foroxidative stress tolerance; mediatespleiotropic drug and metal resistance;localized to the nucleus in response to thepresence of oxidants 0.027410.40247&radic&radic&radic&radic&radic S000003102PCL10YGL134WverifiedPho85p cyclin; recruits, activates, and targets Pho85pcyclin-dependent protein kinase to itssubstrate 0.027410.40247&radic&radic S000004206CPR6YLR216CverifiedPeptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzesthe cis-trans isomerization of peptide bondsN-terminal to proline residues; binds to Hsp82pand contributes to chaperone activity 0.027360.40247&radic&radic&radic S000001709VPS1YKR001CverifiedGTPase required for vacuolar protein sorting, functions inactin cytoskeleton organization via itsinteraction with Sla1p; required for lateGolgi-retention of some proteins includingKex2p; involved in regulating peroxisomebiogenesis 0.027340.40139&radic&radic&radic&radic&radic S000002880TRS31YDR472WverifiedOne of 10 subunits of the transport protein particle (TRAPP)complex of the cis-Golgi which mediates vesicledocking and fusion; involved in endoplasmicreticulum (ER) to Golgi membrane traffic 0.027240.40139 S000005853MYO2YOR326WverifiedOne of two type V myosin motors (along with MYO4) involved inactin-based transport of cargos; required forthe polarized delivery of secretory vesicles,the vacuole, late Golgi elements, peroxisomes,and the mitotic spindle 0.027290.40139&radic&radic&radic&radic S000002476DOA4YDR069CverifiedUbiquitin hydrolase, required for recycling ubiquitin fromproteasome-bound ubiquitinated intermediates,acts at the late endosome/prevacuolarcompartment to recover ubiquitin fromubiquitinated membrane proteins en route to thevacuole 0.027270.40139&radic S000004550TUB1YML085CverifiedAlpha-tubulin; associates with beta-tubulin (Tub2p) to formtubulin dimer, which polymerizes to formmicrotubules 0.027240.4001&radic&radic S000002907LCD1YDR499WverifiedEssential protein required for the DNA integrity checkpointpathways; interacts physically with Mec1p;putative homolog of S. pombe Rad26 and humanATRIP 0.027240.4001&radic&radic&radic S000004520IMD4YML056CverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 0.027160.4001&radic S000006229CCL1YPR025CverifiedCyclin associated with protein kinase Kin28p, which is theTFIIH-associated carboxy-terminal domain (CTD)kinase involved in transcription initiation atRNA polymerase II promoters 0.027060.39865&radic S000003484GCN5YGR252WverifiedHistone acetyltransferase, acetylates N-terminal lysines onhistones H2B and H3; catalytic subunit of theADA and SAGA histone acetyltransferasecomplexes; founding member of the Gcn5p-relatedN-acetyltransferase superfamily 0.027090.39865&radic S000001596RAD27YKL113Cverified5' to 3' exonuclease, 5' flap endonuclease, required forOkazaki fragment processing and maturation aswell as for long-patch base-excision repair;member of the S. pombe RAD2/FEN1 family 0.027020.39865&radic&radic S000002482PPH3YDR075WverifiedCatalytic subunit of an evolutionarily conserved proteinphosphatase complex containing Psy2p and theregulatory subunit Psy4p; required forcisplatin resistance; involved in activation ofGln3p 0.027060.39865&radic&radic&radic&radic&radic&radic S000003804POL32YJR043CverifiedThird subunit of DNA polymerase delta, involved in chromosomalDNA replication; required for error-prone DNAsynthesis in the presence of DNA damage andprocessivity; interacts with Hys2p, PCNA(Pol30p), and Pol1p &radic0.0270.39865&radic&radic S000005773SRL1YOR247WverifiedMannoprotein that exhibits a tight association with the cellwall, required for cell wall stability in theabsence of GPI-anchored mannoproteins; has ahigh serine-threonine content; expression isinduced in cell wall mutants 0.027020.39865&radic&radic&radic&radic&radic S000002484SED1YDR077WverifiedMajor stress-induced structural GPI-cell wall glycoprotein instationary-phase cells, associates withtranslating ribosomes, possible role inmitochondrial genome maintenance; ORF containstwo distinct variable minisatellites 0.027120.39865&radic&radic&radic&radic&radic S000004840TAF7YMR227CverifiedTFIID subunit (67 kDa), involved in RNA polymerase IItranscription initiation 0.026980.39683&radic&radic&radic&radic S000002709CFT1YDR301WverifiedRNA-binding subunit of the mRNA cleavage and polyadenylationfactor; involved in poly(A) site recognitionand required for both pre-mRNA cleavage andpolyadenylation, 51% sequence similarity withmammalian AAUAA-binding subunit of CPSF 0.026930.39683&radic&radic&radic S000001923ECO1YFR027WverifiedAcetyltransferase required for the establishment of sisterchromatid cohesion during DNA replication, butnot for its maintenance during G2 and M phases;also required for postreplicative double-strandbreak repair; interacts with Chl1p 0.026850.39683&radic&radic&radic&radic S000001214ATG7YHR171WverifiedAutophagy-related protein and dual specificity member of the E1family of ubiquitin-activating enzymes;mediates the conjugation of Atg12p with Atg5pand Atg8p with phosphatidylethanolamine,required steps in autophagosome formation. 0.026980.39683 S000004970SSN8YNL025CverifiedCyclin-like component of the RNA polymerase II holoenzyme,involved in phosphorylation of the RNApolymerase II C-terminal domain; involved inglucose repression and telomere maintenance 0.026840.39683&radic&radic S000004665RNA14YMR061WverifiedCleavage and polyadenylation factor I (CF I) component involvedin cleavage and polyadenylation of mRNA 3'ends; bridges interaction between Rna15p andHrp1p in the CF I complex 0.02690.39683&radic S000002575CDC37YDR168WverifiedEssential Hsp90p co-chaperone; necessary for passage throughthe START phase of the cell cycle 0.026890.39683&radic&radic&radic S000004219CDC42YLR229CverifiedSmall rho-like GTPase, essential for establishment andmaintenance of cell polarity; mutants havedefects in the organization of actin andseptins 0.026880.39683 S000002596CCT6YDR188WverifiedSubunit of the cytosolic chaperonin Cct ring complex, relatedto Tcp1p, essential protein that is requiredfor the assembly of actin and tubulins in vivo;contains an ATP-binding motif 0.026910.39683&radic&radic&radic S000005299ACC1YNR016CverifiedAcetyl-CoA carboxylase, biotin containing enzyme that catalyzesthe carboxylation of acetyl-CoA to formmalonyl-CoA; required for de novo biosynthesisof long-chain fatty acids 0.026790.39649&radic&radic&radic S000004640MSN2YMR037CverifiedTranscriptional activator related to Msn4p; activated in stressconditions, which results in translocation fromthe cytoplasm to the nucleus; binds DNA atstress response elements of responsive genes,inducing gene expression 0.026670.39448&radic&radic S000004580CTK3YML112WverifiedGamma subunit of C-terminal domain kinase I (CTDK-I), whichphosphorylates the C-terminal repeated domainof the RNA polymerase II large subunit (Rpo21p)to affect both transcription and pre-mRNA 3'end processing &radic0.026790.39448&radic&radic S000000437PBP2YBR233WverifiedRNA binding protein with similarity to mammalian heterogeneousnuclear RNP K protein, involved in theregulation of telomere position effect andtelomere length 0.026660.39448&radic&radic S000000330TPS1YBR126CverifiedSynthase subunit of trehalose-6-phosphate synthase/phosphatasecomplex, which synthesizes the storagecarbohydrate trehalose; also found in amonomeric form; expression is induced by thestress response and repressed by the Ras-cAMPpathway 0.026620.39448&radic&radic S000002888DIG2YDR480WverifiedRegulatory protein of unknown function, pheromone-inducible,involved in the regulation of mating-specificgenes and the invasive growth pathway, requiredfor MAP-kinase imposed repression, inhibitspheromone-responsive transcription 0.026680.39448&radic&radic S000004376IKI3YLR384CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;maintains structural integrity of Elongator;homolog of human IKAP, mutations in which causefamilial dysautonomia (FD) 0.026610.39448&radic&radic&radic S000006149CET1YPL228WverifiedBeta (RNA 5'-triphosphatase) subunit of the mRNA cappingenzyme, a heterodimer (the other subunit isCEG1, a guanylyltransferase) involved in addingthe 5' cap to mRNA; the mammalian enzyme is asingle bifunctional polypeptide 0.026650.39448&radic&radic&radic S000004105CFT2YLR115WverifiedSubunit of the mRNA cleavage and polyadenlylation factor (CPF);required for pre-mRNA cleavage, polyadenylationand poly(A) site recognition, 43% similaritywith the mammalian CPSF-100 protein. 0.026740.39448&radic&radic S000000229YBR025CUncharacterizedHypothetical protein 0.026740.39448&radic S000005079FPR1YNL135CverifiedPeptidyl-prolyl cis-trans isomerase (PPIase), binds to thedrugs FK506 and rapamycin; also binds to thenonhistone chromatin binding protein Hmo1p andmay regulate its assembly or function 0.026680.39448&radic&radic&radic S000005932TAF3YPL011CverifiedTFIID subunit (47 kDa), involved in promoter binding and RNApolymerase II transcription initiation 0.026550.39114&radic&radic&radic&radic S000002205SIT4YDL047WverifiedType 2A-related serine-threonine phosphatase that functions inthe G1/S transition of the mitotic cycle;cytoplasmic and nuclear protein that modulatesfunctions mediated by Pkc1p including cell walland actin cytoskeleton organization 0.026520.39114&radic&radic&radic S000004478PPZ1YML016CverifiedSerine/threonine protein phosphatase Z, isoform of Ppz2p;involved in regulation of potassium transport,which affects osmotic stability, cell cycleprogression, and halotolerance 0.026520.39114&radic&radic&radic&radic S000004342ORM2YLR350WverifiedEvolutionarily conserved protein with similarity to Orm1p,required for resistance to agents that inducethe unfolded protein response; human orthologis located in the endoplasmic reticulum 0.026320.39114&radic&radic S000002347PPH22YDL188CverifiedCatalytic subunit of protein phosphatase 2A, functionallyredundant with Pph21p; methylated at Cterminus; forms alternate complexes withseveral regulatory subunits; involved in signaltransduction and regulation of mitosis 0.026380.39114&radic&radic&radic S000004295ACO1YLR304CverifiedAconitase, required for the tricarboxylic acid (TCA) cycle andalso independently required for mitochondrialgenome maintenance; component of themitochondrial nucleoid; mutation leads toglutamate auxotrophy 0.026330.39114&radic&radic S000001390MET18YIL128WverifiedDNA repair and TFIIH regulator, required for both nucleotideexcision repair (NER) and RNA polymerase II(RNAP II) transcription; involved in telomeremaintenance 0.026340.39114&radic&radic S000005783CDC31YOR257WverifiedComponent of the spindle pole body (SPB) half-bridge, requiredfor SPB duplication in mitosis and meiosis II;homolog of mammalian centrin; interacts withKar1p 0.026350.39114&radic&radic&radic S000002314CLB3YDL155WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the G2/M transition; may beinvolved in DNA replication and spindleassembly; accumulates during S phase and G2,then targeted for ubiquitin-mediateddegradation 0.026540.39114&radic&radic S000003200YGL231CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum 0.026580.39114&radic&radic S000005887PDE2YOR360CverifiedHigh-affinity cyclic AMP phosphodiesterase, component of thecAMP-dependent protein kinase signaling system,protects the cell from extracellular cAMP,contains readthrough motif surroundingtermination codon 0.026190.38943&radic&radic&radic S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling 0.026260.38943&radic&radic&radic&radic&radic S000006222RLF2YPR018WverifiedLargest subunit (p90) of the Chromatin Assembly Complex (CAF-I)with Cac2p and Msi1p that assembles newlysynthesized histones onto recently replicatedDNA; involved in the maintenance oftranscriptionally silent chromatin 0.026190.38943 S000003944SPA2YLL021WverifiedComponent of the polarisome, which functions in actincytoskeletal organization during polarizedgrowth; acts as a scaffold for Mkk1p and Mpk1pcell wall integrity signaling components;potential Cdc28p substrate 0.026310.38943&radic&radic&radic S000002444KRS1YDR037WverifiedLysyl-tRNA synthetase; also identified as a negative regulatorof general control of amino acid biosynthesis 0.026250.38943&radic S000004515GAL80YML051WverifiedTranscriptional regulator involved in the repression of GALgenes in the absence of galactose; inhibitstranscriptional activation by Gal4p; inhibitionrelieved by Gal3p or Gal1p binding 0.026260.38943&radic&radic S000001312PCL7YIL050WverifiedPho85p cyclin of the Pho80p subfamily, forms a functionalkinase complex with Pho85p which phosphorylatesMmr1p and is regulated by Pho81p; involved inglycogen metabolism, expression is cell-cycleregulated 0.026310.38943&radic&radic&radic S000006085MLH3YPL164CverifiedProtein involved in DNA mismatch repair; forms a complex withMlh1p to promote meiotic crossing-over;mammalian homolog is implicated mammalianmicrosatellite instability 0.025960.386&radic&radic&radic S000004712YKU80YMR106CverifiedSubunit of the telomeric Ku complex (Yku70p-Yku80p), involvedin telomere length maintenance, structure andtelomere position effect; relocates to sites ofdouble-strand cleavage to promote nonhomologousend joining during DSB repair 0.025930.386&radic&radic S000003279TFC4YGR047CverifiedOne of six subunits of the RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part of theTauA domain of TFIIIC that binds BoxA DNApromoter sites of tRNA and similar genes; hasTPR motifs; human homolog is TFIIIC-102 0.026030.386&radic&radic&radic&radic&radic S000001734GCN3YKR026CverifiedAlpha subunit of the translation initiation factor eIF2B, theguanine-nucleotide exchange factor for eIF2;activity subsequently regulated byphosphorylated eIF2; first identified as apositive regulator of GCN4 expression 0.025960.386&radic&radic S000005201SIP3YNL257CverifiedProtein that activates transcription through interaction withDNA-bound Snf1p, C-terminal region has aputative leucine zipper motif; potential Cdc28psubstrate 0.025920.386&radic&radic&radic&radic S000004837MRE11YMR224CverifiedSubunit of a complex with Rad50p and Xrs2p (RMX complex) thatfunctions in repair of DNA double-strand breaksand in telomere stability, exhibits nucleaseactivity that appears to be required for RMXfunction; widely conserved 0.026040.386&radic&radic&radic S000000319LYS2YBR115CverifiedAlpha aminoadipate reductase, catalyzes the reduction ofalpha-aminoadipate to alpha-aminoadipate6-semialdehyde, which is the fifth step inbiosynthesis of lysine; activation requiresposttranslational phosphopantetheinylation byLys5p 0.025910.386&radic&radic S000004998MSG5YNL053WverifiedDual-specificity protein phosphatase required for maintenanceof a low level of signaling through the cellintegrity pathway; regulates and is regulatedby Slt2p; also required for adaptive responseto pheromone 0.02610.386&radic&radic S000001375SDP1YIL113WverifiedStress-inducible dual-specificity MAP kinase phosphatase,negatively regulates Slt2p MAP kinase by directdephosphorylation, diffuse localization undernormal conditions shifts to punctatelocalization after heat shock 0.025910.386&radic&radic S000000449ISW1YBR245CverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPase thatforms a complex with Ioc2p and Ioc4p toregulate transcription elongation, and acomplex with Ioc3p to repress transcriptioninitiation 0.025840.386&radic&radic S000006140PCL8YPL219WverifiedCyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) tophosphorylate and regulate glycogen synthase,also activates Pho85p for Glc8p phosphorylation 0.026030.386&radic&radic&radic&radic&radic&radic&radic S000001673CNB1YKL190WverifiedCalcineurin B; the regulatory subunit of calcineurin, aCa++/calmodulin-regulated protein phosphatasewhich regulates Crz1p (a stress-responsetranscription factor), the other calcineurinsubunit is encoded by CNA1 and/or CMP1 0.02610.386&radic&radic&radic&radic S000000404BEM1YBR200WverifiedProtein containing SH3-domains, involved in establishing cellpolarity and morphogenesis; functions as ascaffold protein for complexes that includeCdc24p, Ste5p, Ste20p, and Rsr1p 0.026120.386&radic&radic S000003101ITC1YGL133WverifiedComponent of the ATP-dependent Isw2p-Itc1p chromatin remodelingcomplex, required for repression of a-specificgenes, repression of early meiotic genes duringmitotic growth, and repression of INO1 0.025920.386&radic S000005734PTP2YOR208WverifiedPhosphotyrosine-specific protein phosphatase involved in theinactivation of mitogen-activated proteinkinase (MAPK) during osmolarity sensing;dephosporylates Hog1p MAPK and regulates itslocalization; localized to the nucleus 0.025830.386&radic&radic&radic S000000022LTE1YAL024CverifiedPutative GDP/GTP exchange factor required for mitotic exit atlow temperatures; acts as a guanine nucleotideexchange factor (GEF) for Tem1p, which is a keyregulator of mitotic exit; physicallyassociates with Ras2p-GTP 0.026030.386&radic S000006339CTF4YPR135WverifiedChromatin-associated protein, required for sister chromatidcohesion; interacts with DNA polymerase alpha(Pol1p) and may link DNA synthesis to sisterchromatid cohesion 0.025860.386&radic&radic S000001441MPH1YIR002CverifiedMember of the DEAH family of helicases, functions in anerror-free DNA damage bypass pathway thatinvolves homologous recombination, mutationsconfer a mutator phenotype 0.025770.3851&radic&radic S000000916BOI2YER114CverifiedProtein implicated in polar growth, functionally redundant withBoi1p; interacts with bud-emergence proteinBem1p; contains an SH3 (src homology 3) domainand a PH (pleckstrin homology) domain 0.025810.3851&radic&radic S000002578HSP42YDR171WverifiedSmall cytosolic stress-induced chaperone that formsbarrel-shaped oligomers and suppresses theaggregation of non-native proteins; oligomerdissociation is not required for function;involved in cytoskeleton reorganization afterheat shock 0.025750.3851&radic&radic&radic&radic S000002591PLP1YDR183WverifiedProtein with a possible role in folding of beta-tubulin; hassimilarity to phosducins, which are GTPaseinhibitors 0.025330.37932&radic&radic&radic&radic&radic&radic S000005559EXO1YOR033Cverified5'-3' exonuclease and flap-endonuclease involved inrecombination, double-strand break repair andDNA mismatch repair; member of the Rad2pnuclease family, with conserved N and Inuclease domains 0.025630.37932&radic&radic&radic&radic S000003424TDH3YGR192CverifiedGlyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involvedin glycolysis and gluconeogenesis; tetramerthat catalyzes the reaction ofglyceraldehyde-3-phosphate to 1,3bis-phosphoglycerate; detected in the cytoplasmand cell-wall 0.025650.37932&radic&radic&radic&radic&radic&radic S000005293CSE2YNR010WverifiedComponent of the Med9/10 module, which is a subcomplex withinthe RNA polymerase II Mediator complex;required for regulation of RNA polymerase IIactivity 0.025480.37932&radic S000002851SSN2YDR443CverifiedProtein required for stable association of Srb10p-Srb11p kinasewith RNA polymerase holoenzyme; subunit of theRNA polymerase II mediator complex; essentialfor transcriptional regulation 0.025250.37932&radic&radic S000003465PHO81YGR233CverifiedCyclin-dependent kinase (CDK) inhibitor, regulatesPho80p-Pho85p and Pcl7p-Pho85p cyclin-CDKcomplexes in response to phosphate levels;required for derepression of PHO5;transcriptionally regulated by Pho4p and Pho2p 0.025350.37932&radic&radic&radic&radic S000000735GCN4YEL009CverifiedTranscriptional activator of amino acid biosynthetic genes inresponse to amino acid starvation; expressionis tightly regulated at both thetranscriptional and translational levels 0.025730.37932&radic&radic&radic S000002164PTC1YDL006WverifiedType 2C protein phosphatase (PP2C); inactivates the osmosensingMAPK cascade by dephosphorylating Hog1p;mutation delays mitochondrial inheritance;deletion reveals defects in precursor tRNAsplicing, sporulation and cell separation 0.025360.37932&radic S000000099HTA2YBL003CverifiedOne of two nearly identical (see also HTA1) histone H2Asubtypes; core histone required for chromatinassembly and chromosome function; DNAdamage-dependent phosphorylation by Mec1pfacilitates DNA repair; acetylated by Nat4p 0.025610.37932&radic&radic&radic&radic S000006385SEC23YPR181CverifiedGTPase-activating protein; component of the Sec23p-Sec24pheterodimeric complex of the COPII vesiclecoat, involved in ER to Golgi transport andautophagy; stimulates the GDP-bound form ofSar1p 0.025240.37932&radic&radic&radic S000004534POB3YML069WverifiedSubunit of the heterodimeric FACT complex (Spt16p-Pob3p), whichfacilitates RNA Polymerase II transcriptionelongation through nucleosomes by destabilizingand then reassembling nucleosome structure 0.025690.37932&radic S000004477TAF11YML015CverifiedTFIID subunit (40 kDa), involved in RNA polymerase IItranscription initiation, similar to histone H3with atypical histone fold motif of Spt3-liketranscription factors 0.025220.37932 S000003318PIL1YGR086CverifiedPrimary component of eisosomes, which are large immobile patchstructures at the cell cortex associated withendocytosis, along with Lsp1p and Sur7p; nullmutants show activation of Pkc1p/Ypk1p stressresistance pathways 0.025230.37932&radic S000000684ABP1YCR088WverifiedActin-binding protein of the cortical actin cytoskeleton,important for activation of the Arp2/3 complexthat plays a key role actin in cytoskeletonorganization 0.025450.37932&radic S000004476TRM9YML014WverifiedtRNA methyltransferase, catalyzes the esterification ofmodified uridine nucleotides in tRNAs, creating5-methylcarbonylmethyluridine in tRNA(Arg3) and5-methylcarbonylmethyl-2-thiouridine intRNA(Glu); may have a role in stress response 0.02550.37932&radic&radic&radic S000000181BOI1YBL085WverifiedProtein implicated in polar growth, functionally redundant withBoi2p; interacts with bud-emergence proteinBem1p; contains an SH3 (src homology 3) domainand a PH (pleckstrin homology) domain 0.02570.37932&radic&radic&radic&radic S000001927SMC2YFR031CverifiedComponent of the condensin complex, essential SMC chromosomalATPase family member that forms a complex withSmc4p to form the active ATPase; Smc2p/Smc4pcomplex binds DNA, possibly in the cleft formedby the coiled-coil of the folded dimer 0.025410.37932&radic&radic S000005554CIN5YOR028CverifiedBasic leucine zipper transcriptional factor of the yAP-1 familythat mediates pleiotropic drug resistance andsalt tolerance; localizes constitutively to thenucleus 0.025610.37932&radic&radic&radic&radic&radic S000003146MPT5YGL178WverifiedMember of the Puf family of RNA-binding proteins; binds tomRNAs encoding chromatin modifiers and spindlepole body components; involved in longevity,maintenance of cell wall integrity, andsensitivity to and recovery from pheromonearrest 0.025640.37932&radic&radic S000002163MED2YDL005CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation 0.025520.37932&radic&radic S000001011APM2YHL019CverifiedProtein of unknown function, homologous to the medium chain ofmammalian clathrin-associated protein complex;involved in vesicular transport 0.025680.37932&radic&radic S000001019RIM101YHL027WverifiedTranscriptional repressor involved in response to pH and incell wall construction; required for alkalinepH-stimulated haploid invasive growth andsporulation; activated by proteolyticprocessing; similar to A. nidulans PacC 0.025660.37932&radic&radic&radic&radic S000000689CDC39YCR093WverifiedComponent of the CCR4-NOT complex, which has multiple roles inregulating mRNA levels including regulation oftranscription and destabilizing mRNAs bydeadenylation; basal transcription factor 0.025480.37932&radic&radic&radic&radic S000005580VHS3YOR054CverifiedFunctionally redundant (see also SIS2) inhibitory subunit ofPpz1p, a PP1c-related ser/thr proteinphosphatase Z isoform; synthetically lethalwith sis2; putative phosphopantothenoylcysteinedecarboxylase involved in coenzyme Abiosynthesis 0.025690.37932&radic&radic S000000435SWC5YBR231CuncharacterizedProtein of unknown function, component of the SWR1 complex,which exchanges histone variant H2AZ (Htz1p)for chromatin-bound histone H2A 0.025260.37932&radic&radic&radic S000002283HNT1YDL125CverifiedAdenosine 5'-monophosphoramidase; interacts physically andgenetically with Kin28p, a CDK and TFIIKsubunit, and genetically with CAK1; member ofthe histidine triad (HIT) superfamily ofnucleotide-binding proteins and similar to Hint 0.025350.37932&radic&radic&radic S000006395QCR2YPR191WverifiedSubunit 2 of the ubiquinol cytochrome-c reductase complex,which is a component of the mitochondrial innermembrane electron transport chain;transcription is regulated by Hap1p,Hap2p/Hap3p, and heme 0.025650.37932&radic&radic&radic S000000397MED8YBR193CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation 0.025240.37932&radic&radic&radic S000001222OYE2YHR179WverifiedWidely conserved NADPH oxidoreductase containing flavinmononucleotide (FMN), homologous to Oye3p withslight differences in ligand binding andcatalytic properties; may be involved in sterolmetabolism 0.025590.37932&radic&radic&radic&radic S000005441IRA2YOL081WverifiedGTPase-activating protein that negatively regulates RAS byconverting it from the GTP- to the GDP-boundinactive form, required for reducing cAMPlevels under nutrient limiting conditions, hassimilarity to Ira1p and human neurofibromin 0.025410.37932&radic&radic&radic&radic S000000215IPP1YBR011CverifiedCytoplasmic inorganic pyrophosphatase (PPase), catalyzes therapid exchange of oxygens from Pi with water,highly expressed and essential for viability,active-site residues show identity to thosefrom E. coli PPase