Yfunc lets you browse current and predicted gene functions in yeast

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Prediction of GO:0016893 "endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters"

GO branch: MF
Number of currently annotated genes: 22

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest Huh:nucleusLum:SulfinpyrazoneLum:NifedipineLum:TrifluoperazineLum:CarbendazimLum:PromethazineLum:NaproxenGiaever:methotrexate_250uMTAP:152Lum:Diltiazem S000001104RPP1YHR062CverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends &radic0.553841&radic&radic&radic&radic&radic&radic S000000371POP7YBR167CverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends &radic0.54251&radic S000005226POP3YNL282WverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends &radic0.503580.98445&radic&radic&radic&radic&radic&radic&radic S000000031POP5YAL033WverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends &radic0.527350.98445&radic&radic&radic&radic&radic&radic S000000461POP4YBR257WverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends; binds to the RPR1 RNAsubunit in Rnase P &radic0.510540.98445&radic&radic&radic&radic&radic&radic&radic S000005165POP1YNL221CverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends; binds to the RPR1 RNAsubunit in Rnase P &radic0.486370.97561&radic&radic&radic&radic&radic&radic&radic&radic S000000114POP8YBL018CverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends &radic0.393640.96766&radic&radic&radic&radic&radic&radic S000003262POP6YGR030CverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends &radic0.428980.96766&radic&radic&radic&radic&radic&radic S000002886SNM1YDR478WverifiedSubunit of RNase MRP, which cleaves pre-rRNA; not sharedbetween Rnase MRP and nuclear Rnase P, incontrast to all other Rnase MRP proteinsubunits; binds to the NME1 RNA subunit ofRnase MRP 0.276460.93446&radic S000003490RAD2YGR258CverifiedSingle-stranded DNA endonuclease, cleaves single-stranded DNAduring nucleotide excision repair to excisedamaged DNA; subunit of Nucleotide ExcisionRepair Factor 3 (NEF3); homolog of human XPGprotein 0.17480.87386&radic S000003744NUC1YJL208CverifiedMajor mitochondrial nuclease, has RNAse and DNA endo- andexonucleolytic activities; has a role inmitochondrial recombination 0.143820.83911&radic&radic&radic&radic S000001596RAD27YKL113Cverified5' to 3' exonuclease, 5' flap endonuclease, required forOkazaki fragment processing and maturation aswell as for long-patch base-excision repair;member of the S. pombe RAD2/FEN1 family &radic0.116570.79951&radic&radic&radic&radic&radic&radic S000002671DIN7YDR263CverifiedMitochondrial nuclease functioning in DNA repair andreplication, modulates the stability of themitochondrial genome, induced by exposure tomutagens, also induced during meiosis at a timenearly coincident with commitment torecombination 0.083510.74577&radic&radic&radic S000004626MRPL3YMR024WverifiedMitochondrial ribosomal protein of the large subunit 0.073750.72539 S000005559EXO1YOR033Cverified5'-3' exonuclease and flap-endonuclease involved inrecombination, double-strand break repair andDNA mismatch repair; member of the Rad2pnuclease family, with conserved N and Inuclease domains &radic0.071590.71737&radic&radic&radic&radic S000005062DCP2YNL118CverifiedCatalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex,which removes the 5' cap structure from mRNAsprior to their degradation; member of the Nudixhydrolase family 0.039250.58366 S000002501YDR094WDubiousHypothetical protein 0.037560.57576&radic&radic&radic&radic&radic S000000065RFA1YAR007CverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 0.030190.5177&radic&radic&radic&radic&radic&radic&radic S000000843YEN1YER041WverifiedProtein of unknown function, has similarity to endonucleaseRth1p; potentially phosphorylated by Cdc28p 0.0270.50152&radic&radic S000004777MLH1YMR167WverifiedProtein required for mismatch repair in mitosis and meiosis,postmeiotic segregation, and spore viability;forms a complex with Pms1p and Msh2p to repairmismatched DNA; human homolog is associatedwith hereditary non-polyposis colon cancer 0.023450.47504&radic&radic&radic&radic&radic S000003709RFA3YJL173CverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 0.022770.46979&radic&radic&radic&radic&radic S000004304MRPL15YLR312W-AverifiedMitochondrial ribosomal protein of the large subunit 0.020350.44787&radic&radic S000005029MKT1YNL085WverifiedProtein that forms a complex with Pbp1p that may mediateposttranscriptional regulation of HOendonuclease; involved in propagation of M2dsRNA satellite of L-A virus 0.020130.44609 S000000378YBR174CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective 0.018920.42713&radic&radic&radic S000000741EDC3YEL015WverifiedNon-essential conserved protein of unknown function, plays arole in mRNA decapping by specificallyaffecting the function of the decapping enzymeDcp1p; localizes to cytoplasmic mRNA processingbodies 0.018750.42713&radic&radic&radic&radic&radic S000004494RAD52YML032CverifiedProtein that stimulates strand exchange by facilitating Rad51pbinding to single-stranded DNA; annealscomplementary single-stranded DNA; involved inthe repair of double-strand breaks in DNAduring vegetative growth and meiosis 0.018340.42713&radic&radic&radic&radic&radic&radic S000002718SUM1YDR310CverifiedTranscriptional repressor required for mitotic repression ofmiddle sporulation-specific genes; involved intelomere maintenance, regulated by thepachytene checkpoint 0.0180.42405&radic&radic&radic&radic&radic&radic S000002708PRO1YDR300CverifiedGamma-glutamyl kinase, catalyzes the first step in prolinebiosynthesis 0.01710.4095&radic&radic&radic&radic&radic S000002495SLU7YDR088CverifiedRNA splicing factor, required for ATP-independent portion of2nd catalytic step of spliceosomal RNAsplicing; interacts with Prp18p; contains zincknuckle domain 0.016420.40232&radic&radic&radic&radic&radic S000005509DCP1YOL149WverifiedSubunit of the Dcp1p-Dcp2p decapping enzyme complex, whichremoves the 5' cap structure from mRNAs priorto their degradation; enhances the activity ofcatalytic subunit Dcp2p; regulated by DEAD boxprotein Dhh1p 0.016350.40232 S000003326VAS1YGR094WverifiedMitochondrial and cytoplasmic valyl-tRNA synthetase 0.015880.39804&radic&radic&radic&radic&radic S000005305MRPL50YNR022CverifiedMitochondrial ribosomal protein of the large subunit, notessential for mitochondrial translation 0.015790.39804 S000004224TOP3YLR234WverifiedDNA Topoisomerase III, conserved protein that functions in acomplex with Sgs1p and Rmi1p to relaxsingle-stranded negatively-supercoiled DNApreferentially, involved in telomere stabilityand regulation of mitotic recombination 0.015630.39607&radic&radic&radic&radic&radic S000005224ERG24YNL280CverifiedC-14 sterol reductase, acts in ergosterol biosynthesis; mutantsaccumulate the abnormal sterol ignosterol(ergosta-8,14 dienol), and are viable underanaerobic growth conditions but inviable onrich medium under aerobic conditions 0.015420.39453&radic&radic&radic&radic&radic&radic S000005850PRO2YOR323CverifiedGamma-glutamyl phosphate reductase, catalyzes the second stepin proline biosynthesis 0.014840.38205&radic&radic&radic&radic&radic&radic S000004802SGS1YMR190CverifiedNucleolar DNA helicase of the RecQ family involved inmaintenance of genome integrity, regulateschromosome synapsis and meiotic crossing over;has similarity to human BLM and WRN helicasesimplicated in Bloom and Werner syndromes 0.014340.36741&radic&radic&radic&radic&radic S000003992NOC3YLR002CverifiedProtein that forms a nuclear complex with Noc2p that binds to66S ribosomal precursors to mediate theirintranuclear transport; also binds to chromatinto promote the association of DNA replicationfactors and replication initiation 0.012950.35487&radic&radic&radic&radic&radic S000004122YLR132CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to mitochondria and nucleus; YLR132C is an essential gene 0.013020.35487&radic&radic&radic&radic&radic S000000392NTC20YBR188CverifiedMember of a complex, including Prp19p, that binds to thespliceosome; required for pre-mRNA splicing 0.012650.35129&radic&radic&radic&radic&radic&radic&radic S000000452HIS7YBR248CverifiedImidazole glycerol phosphate synthase (glutamineamidotransferase:cyclase), catalyzes the fifthand sixth steps of histidine biosynthesis andalso produces 5-aminoimidazole-4-carboxamideribotide (AICAR), a purine precursor 0.012080.34478&radic&radic&radic&radic&radic S000000605PGK1YCR012Wverified3-phosphoglycerate kinase, catalyzes transfer of high-energyphosphoryl groups from the acyl phosphate of1,3-bisphosphoglycerate to ADP to produce ATP;key enzyme in glycolysis and gluconeogenesis 0.012080.34459&radic&radic&radic&radic&radic&radic&radic&radic S000001578YJU2YKL095WverifiedEssential nuclear protein; putative spliceosomal componentinvolved in mRNA splicing, based oncomputational analysis of large-scaleprotein-protein interaction data 0.011980.34364&radic&radic&radic&radic&radic&radic S000003234SWC4YGR002CverifiedProtein of unknown function, component of the Swr1p complexthat incorporates Htz1p into chromatin;component of the NuA4 histone acetyltransferasecomplex 0.011430.33391&radic&radic&radic&radic S000005450MSH2YOL090WverifiedProtein that forms heterodimers with Msh3p and Msh6p that bindto DNA mismatches to initiate the mismatchrepair process; contains a Walker ATP-bindingmotif required for repair activity; Msh2p-Msh6pbinds to and hydrolyzes ATP 0.011150.3305&radic&radic S000003428FYV8YGR196CverifiedProtein of unknown function, required for survival uponexposure to K1 killer toxin 0.011040.32738&radic&radic&radic&radic S000000734YEL008WDubiousHypothetical protein predicted to be involved in metabolism 0.010740.32388&radic&radic&radic&radic&radic&radic S000005805RFM1YOR279CverifiedDNA-binding protein required for vegetative repression ofmiddle sporulation genes; specificity factorthat directs the Hst1p histone deacetylase tosome of the promoters regulated by Sum1p;involved in telomere maintenance 0.01060.32074&radic&radic&radic&radic&radic S000001204YAP1801YHR161CverifiedProtein involved in clathrin cage assembly; binds Pan1p andclathrin; homologous to Yap1802p, member of theAP180 protein family 0.010280.31462&radic&radic&radic&radic S000003414YGR182CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W 0.010120.30924&radic&radic&radic S000002466UBC5YDR059CverifiedUbiquitin-conjugating enzyme that mediates selectivedegradation of short-lived and abnormalproteins, central component of the cellularstress response; expression is heat inducible 0.009970.30924&radic&radic&radic&radic S000003411OKP1YGR179CverifiedOuter kinetochore protein, required for accurate mitoticchromosome segregation; component of thekinetochore sub-complex COMA (Ctf19p, Okp1p,Mcm21p, Ame1p) that functions as a platform forkinetochore assembly 0.009960.30924&radic&radic&radic&radic S000002644FMN1YDR236CverifiedRiboflavin kinase, phosphorylates riboflavin to form riboflavinmonophosphate (FMN), which is a necessarycofactor for many enzymes; localizes tomicrosomes and to the mitochondrial innermembrane 0.009690.30194&radic&radic&radic&radic&radic&radic S000000317YBR113WDubiousHypothetical protein 0.009380.30143 S000001602VPH2YKL119CverifiedIntegral membrane protein required for vacuolar H+-ATPase(V-ATPase) function, although not an actualcomponent of the V-ATPase complex; functions inthe assembly of the V-ATPase; localized to theendoplasmic reticulum (ER) 0.009360.29825&radic&radic&radic&radic&radic&radic S000001709VPS1YKR001CverifiedGTPase required for vacuolar protein sorting, functions inactin cytoskeleton organization via itsinteraction with Sla1p; required for lateGolgi-retention of some proteins includingKex2p; involved in regulating peroxisomebiogenesis 0.009340.29825&radic&radic&radic&radic&radic&radic S000004849TAF9YMR236WverifiedSubunit (17 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification, similar to histone H3 0.009150.2973&radic&radic&radic&radic&radic&radic S000005026PMS1YNL082WverifiedATP-binding protein required for mismatch repair in mitosis andmeiosis; functions as a heterodimer with Mlh1p,binds double- and single-stranded DNA via itsN-terminal domain, similar to E. coli MutL 0.008860.29066&radic&radic S000003388PTI1YGR156WverifiedPta1p Interacting protein 0.008750.28941&radic&radic&radic S000003223FZF1YGL254WverifiedTranscription factor involved in sulfite metabolism, soleidentified regulatory target is SSU1,overexpression suppresses sulfite-sensitivityof many unrelated mutants due tohyperactivation of SSU1, contains five zincfingers 0.00870.28695&radic&radic&radic S000004837MRE11YMR224CverifiedSubunit of a complex with Rad50p and Xrs2p (RMX complex) thatfunctions in repair of DNA double-strand breaksand in telomere stability, exhibits nucleaseactivity that appears to be required for RMXfunction; widely conserved 0.008520.28163&radic&radic&radic&radic S000000464RGD1YBR260CverifiedGTPase-activating protein (RhoGAP) for Rho3p and Rho4p,possibly involved in control of actincytoskeleton organization 0.00830.28163&radic&radic&radic S000000804NOP16YER002WverifiedConstituent of 66S pre-ribosomal particles, involved in 60Sribosomal subunit biogenesis 0.008530.28163&radic&radic&radic&radic S000000435SWC5YBR231CuncharacterizedProtein of unknown function, component of the SWR1 complex,which exchanges histone variant H2AZ (Htz1p)for chromatin-bound histone H2A 0.008290.28163&radic&radic&radic&radic&radic&radic S000005943RAD1YPL022WverifiedSingle-stranded DNA endonuclease (with Rad10p), cleavessingle-stranded DNA during nucleotide excisionrepair and double-strand break repair; subunitof Nucleotide Excision Repair Factor 1 (NEF1);homolog of human XPF protein 0.008270.28163&radic&radic&radic&radic&radic S000001164YHR122WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; may be involved in transcription; YHR122W is an essential gene 0.00810.27913&radic&radic&radic&radic&radic S000005956YPL035CDubiousHypothetical protein 0.008130.27913&radic&radic&radic S000004267YSH1YLR277CverifiedPutative endonuclease, subunit of the mRNA cleavage andpolyadenylation specificity complex requiredfor 3' processing of mRNAs 0.008240.27913&radic&radic&radic&radic S000002831CAD1YDR423CverifiedAP-1-like bZIP transcriptional activator involved in multiplestress responses, iron metabolism, andpleiotropic drug resistance; controls a set ofgenes involved in stabilizing proteins, bindsconsensus sequence TTACTAA; 5' UTR containsuORFs 0.008220.27913&radic&radic&radic S000000472MRPL37YBR268WverifiedMitochondrial ribosomal protein of the large subunit 0.00790.27596&radic&radic S000006124TPK2YPL203WverifiedSubunit of cytoplasmic cAMP-dependent protein kinase, whichcontains redundant catalytic subunits Tpk1p,Tpk2p, and Tpk3p and regulatory subunit Bcy1p;promotes vegetative growth in response tonutrients; activates filamentous growth 0.007910.27596&radic&radic&radic&radic&radic&radic&radic S000002824SYF1YDR416WverifiedComponent of the spliceosome complex involved in pre-mRNAsplicing; involved in regulation of cell cycleprogression; similar to Drosophila crooked neckprotein 0.007780.27333&radic&radic&radic&radic S000000443YBR239CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR239C is not an essential gene 0.007740.27201&radic&radic&radic&radic&radic&radic&radic S000005046POL1YNL102WverifiedCatalytic subunit of the DNA polymerase alpha-primase complex,required for the initiation of DNA replicationduring mitotic DNA synthesis and premeiotic DNAsynthesis 0.007650.26882&radic&radic&radic&radic S000001197RTT107YHR154WverifiedProtein implicated in Mms22-dependent DNA repair during Sphase, DNA damage induces phosphorylation byMec1p at one or more SQ/TQ motifs; interactswith Mms22p and Slx4p; has four BRCT domains;has a role in regulation of Ty1 transposition 0.00740.26589&radic&radic&radic&radic&radic S000002703HDA2YDR295CverifiedSubunit of a possibly tetrameric trichostatin A-sensitive classII histone deacetylase complex containing anHda1p homodimer and an Hda2p-Hda3p heterodimer;involved in telomere maintenance 0.007370.26512&radic&radic&radic&radic&radic&radic S000002504MSH6YDR097CverifiedProtein required for mismatch repair in mitosis and meiosis,forms a complex with Msh2p to repair bothsingle-base & insertion-deletion mispairs;potentially phosphorylated by Cdc28p 0.007010.25674&radic&radic&radic&radic&radic S000005195NRD1YNL251CverifiedRNA-binding protein that interacts with the C-terminal domainof the RNA polymerase II large subunit(Rpo21p), required for transcriptiontermination and 3' end maturation ofnonpolyadenylated RNAs 0.007050.25674&radic&radic&radic&radic&radic&radic&radic S000005256RFA2YNL312WverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 0.007240.25674&radic&radic&radic S000000157SKT5YBL061CverifiedActivator of Chs3p (chitin synthase III), recruits Chs3p to thebud neck via interaction with Bni4p; hassimilarity to Shc1p, which activates Chs3pduring sporulation 0.007050.25674&radic&radic&radic&radic&radic&radic&radic S000002828HKR1YDR420WverifiedSerine/threonine rich cell surface protein that contains an EFhand motif; involved in the regulation of cellwall beta-1,3 glucan synthesis and bud siteselection; overexpression confers resistance toHansenula mrakii killer toxin, HM-1 0.007290.25674&radic&radic&radic S000001448MSL1YIR009WverifiedU2B component of U2 snRNP, involved in splicing, binds the U2snRNA stem-loop IV in vitro; does not containthe conserved C-terminal RNA binding domainfound in other family members 0.007170.25674&radic S000000808NUG1YER006WverifiedGTPase that associates with nuclear 60S pre-ribosomes, requiredfor export of 60S ribosomal subunits from thenucleus 0.006950.25674&radic&radic&radic&radic S000004064BUD20YLR074CverifiedProtein involved in bud-site selection; diploid mutants displaya random budding pattern instead of thewild-type bipolar pattern 0.006730.25122&radic&radic&radic&radic&radic S000002668SWM1YDR260CverifiedSubunit of the anaphase-promoting complex, which is an E3ubiquitin ligase that regulates themetaphase-anaphase transition and exit frommitosis; required for activation of thedaughter-specific gene expression and sporewall maturation 0.006620.25122&radic S000004798HSC82YMR186WverifiedCytoplasmic chaperone of the Hsp90 family, redundant infunction and nearly identical with Hsp82p, andtogether they are essential; expressedconstitutively at 10-fold higher basal levelsthat HSP82 and induced 2-3 fold by heat shock 0.006740.25122&radic&radic&radic&radic&radic&radic S000004339KAP95YLR347CverifiedKaryopherin beta, forms a dimeric complex with Srp1p (Kap60p)that mediates nuclear import of cargo proteinsvia a nuclear localization signal (NLS),interacts with nucleoporins to guide transportacross the nuclear pore complex 0.006690.25122&radic&radic&radic S000002518ALT2YDR111CuncharacterizedPutative alanine transaminase (glutamic pyruvic transaminase) 0.006590.24935&radic&radic&radic&radic&radic S000000827GCD11YER025WverifiedGamma subunit of the translation initiation factor eIF2,involved in the identification of the startcodon; binds GTP when forming the ternarycomplex with GTP and tRNAi-Met 0.006120.24048&radic&radic&radic&radic&radic&radic S000003450CRM1YGR218WverifiedMajor karyopherin, involved in export of proteins, RNAs, andribosomal subunits from the nucleus 0.006430.24048&radic&radic&radic&radic S000000468YPT10YBR264CverifiedGTP binding protein that contains the PEST signal sequencespecific for proteolytic enzymes; may beinvolved in vesicular transport; overexpressionleads to accumulation of Golgi-like cisternaewith budding vesicles 0.006450.24048&radic S000005811YOR285WVerifiedProtein of unknown function, localized to the mitochondrial outer membrane 0.006240.24048&radic&radic&radic S000005020MKS1YNL076WverifiedPleiotropic regulatory factor involved in Ras-CAMP and lysinebiosynthetic pathways and nitrogen regulation;involved in retrograde (RTG)mitochondria-to-nucleus signaling 0.006220.24048 S000003996SSK1YLR006CverifiedCytoplasmic response regulator, part of a two-component signaltransducer that mediates osmosensing via aphosphorelay mechanism; dephosphorylated formis degraded by the ubiquitin-proteasome system;potential Cdc28p substrate 0.006080.23978&radic&radic S000006229CCL1YPR025CverifiedCyclin associated with protein kinase Kin28p, which is theTFIIH-associated carboxy-terminal domain (CTD)kinase involved in transcription initiation atRNA polymerase II promoters 0.006060.23902&radic S000003997NSE1YLR007WverifiedEssential subunit of the Mms21-Smc5-Smc6 complex; nuclearprotein required for DNA repair and growth 0.0060.23708&radic&radic&radic&radic&radic S000004315CWC24YLR323CverifiedEssential protein, component of a complex containing Cef1p; hassimilarity to S. pombe Cwf24p 0.006020.23708&radic&radic&radic&radic&radic S000003175SPT16YGL207WverifiedSubunit of the heterodimeric FACT complex (Spt16p-Pob3p),facilitates RNA Polymerase II transcriptionelongation through nucleosomes by destabilizingand then reassembling nucleosome structure 0.006040.23708&radic&radic&radic&radic&radic S000001505CDC16YKL022CverifiedSubunit of the anaphase-promoting complex/cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition; required forsporulation 0.006030.23708&radic&radic&radic&radic&radic&radic&radic S000002553SWI5YDR146CverifiedTranscription factor that activates transcription of genesexpressed at the M/G1 phase boundary and in G1phase; localization to the nucleus occursduring G1 and appears to be regulated byphosphorylation by Cdc28p kinase 0.00580.22972&radic&radic&radic&radic&radic&radic S000003941DPS1YLL018CverifiedCytoplasmic aspartyl-tRNA synthetase, homodimeric enzyme thatcatalyzes the specific aspartylation oftRNA(Asp); class II aminoacyl tRNA synthetase;binding to its own mRNA may conferautoregulation 0.005870.22972&radic&radic&radic&radic&radic&radic&radic S000005959MET31YPL038WverifiedZinc-finger DNA-binding protein, involved in regulatingexpression of the methionine biosyntheticgenes, similar to Met32p 0.005780.22972&radic&radic&radic&radic&radic S000002645MRPL7YDR237WverifiedMitochondrial ribosomal protein of the large subunit 0.00580.22972&radic&radic&radic&radic S000002528DPB4YDR121WverifiedShared subunit of DNA polymerase epsilon and of ISW2/yCHRACchromatin accessibility complex; involved inboth chromosomal DNA replication and ininheritance of telomeric silencing 0.005650.22532&radic&radic&radic&radic&radic S000000743GTT3YEL017WuncharacterizedProtein of unknown function with a possible role in glutathionemetabolism, as suggested by computationalanalysis of large-scale protein-proteininteraction data; GFP-fusion protein localizesto the nuclear periphery 0.005510.22532&radic&radic&radic&radic&radic&radic S000002766GGA1YDR358WverifiedGolgi-localized protein with homology to gamma-adaptin,interacts with and regulates Arf1p and Arf2p ina GTP-dependent manner in order to facilitatetraffic through the late Golgi 0.005560.22532&radic&radic&radic&radic&radic&radic S000004156SEC10YLR166CverifiedEssential 100kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which has the essential function ofmediating polarized targeting of secretoryvesicles to active sites of exocytosis 0.005620.22532&radic&radic&radic S000002770TFC6YDR362CverifiedOne of six subunits of RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part ofTFIIIC TauB domain that binds BoxB promotersites of tRNA and other genes; cooperates withTfc3p in DNA binding; human homolog isTFIIIC-110 0.005530.22532&radic&radic&radic&radic&radic&radic S000005552BUB3YOR026WverifiedKinetochore checkpoint WD40 repeat protein that localizes tokinetochores during prophase and metaphase,delays anaphase in the presence of unattachedkinetochores; forms complexes with Mad1p-Bub1pand with Cdc20p, binds Mad2p and Mad3p 0.005610.22532&radic&radic&radic&radic S000001446YIR007WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene 0.005520.22532 S000001380RHO3YIL118WverifiedNon-essential small GTPase of the Rho/Rac subfamily of Ras-likeproteins involved in the establishment of cellpolarity; GTPase activity positively regulatedby the GTPase activating protein (GAP) Rgd1p 0.00550.22468 S000003521MAL11YGR289CverifiedMaltose permease, inducible high-affinity maltose transporter(alpha-glucoside transporter); encoded in theMAL1 complex locus; member of the 12transmembrane domain superfamily of sugartransporters 0.005470.22373 S000000851TPA1YER049WuncharacterizedProtein of unknown function; interacts with Sup45p (eRF1),Sup35p (eRF3) and Pab1p; has a role intranslation termination efficiency, mRNApoly(A) tail length and mRNA stability 0.005370.22056&radic&radic&radic&radic&radic&radic&radic&radic S000002690YDR282CUncharacterizedHypothetical protein 0.005420.22056 S000000148SAS3YBL052CverifiedHistone acetyltransferase catalytic subunit of NuA3 complexthat acetylates histone H3, involved intranscriptional silencing; homolog of themammalian MOZ proto-oncogene; sas3 gcn5 doublemutation confers lethality 0.005360.22056&radic&radic&radic&radic&radic&radic S000005965YPL044CDubiousHypothetical protein 0.00540.22056&radic&radic&radic S000001318VHR1YIL056WuncharacterizedTranscriptional activator, required for the vitaminH-responsive element (VHRE) mediated inductionof VHT1 (Vitamin H transporter) and BIO5(biotin biosynthesis intermediate transporter)in response to low biotin concentrations 0.005350.22056&radic S000003945HIF1YLL022CverifiedNon-essential component of the HAT-B histone acetyltransferasecomplex (Hat1p-Hat2p-Hif1p), localized to thenucleus; has a role in telomeric silencing 0.005390.22056&radic S000002647YDR239CUncharacterizedHypothetical protein 0.005360.22056&radic&radic&radic&radic&radic&radic&radic S000001722YPT52YKR014CverifiedGTPase, similar to Ypt51p and Ypt53p and to mammalian rab5;required for vacuolar protein sorting andendocytosis 0.00530.21837&radic&radic&radic&radic&radic&radic&radic&radic S000003290YGR058WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 0.005240.21837&radic&radic&radic&radic&radic&radic S000001341AIR1YIL079CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p to regulate methylationof Npl3p, which modulates Npl3p function inmRNA processing and export; has similarity toAir2p 0.005260.21837&radic&radic&radic&radic S000000462SHG1YBR258CverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres 0.005280.21837&radic&radic&radic S000002687RNH202YDR279WverifiedRibonuclease H2 subunit, required for RNase H2 activity &radic0.005220.21837&radic&radic&radic&radic&radic&radic S000002744YDR336WUncharacterizedPutative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene 0.005310.21837&radic&radic S000005206POL2YNL262WverifiedCatalytic subunit of DNA polymerase epsilon, one of the majorchromosomal DNA replication polymerasescharacterized by processivity and proofreadingexonuclease activity; also involved in DNAsynthesis during DNA repair 0.005180.21665&radic&radic&radic&radic&radic S000000688MSH3YCR092CverifiedMismatch repair protein, forms dimers with Msh2p that mediaterepair of insertion or deletion mutations andremoval of nonhomologous DNA ends, contains aPCNA (Pol30p) binding motif required for genomestability 0.005140.21545&radic&radic&radic&radic&radic S000005860YOR333CDubiousHypothetical protein; open reading frame overlaps 5' end of MRS2 gene required for respiratory growth 0.005110.21471 S000005826YOR300WDubiousDubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7 0.005110.21471 S000005852YOR325WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1 0.005110.21471 S000006216YPR012WDubiousHypothetical protein 0.005110.21471 S000000203YBL107CUncharacterizedHypothetical protein 0.005070.21376 S000002709CFT1YDR301WverifiedRNA-binding subunit of the mRNA cleavage and polyadenylationfactor; involved in poly(A) site recognitionand required for both pre-mRNA cleavage andpolyadenylation, 51% sequence similarity withmammalian AAUAA-binding subunit of CPSF 0.005050.21249&radic&radic&radic&radic S000004243YLR253WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene 0.005040.21249&radic&radic&radic S000003499FOL2YGR267CverifiedGTP-cyclohydrolase I, catalyzes the first step in the folicacid biosynthetic pathway 0.005020.21249&radic&radic&radic&radic&radic S000005825BUD7YOR299WverifiedMember of the Chs5p-Arf1p-binding proteins (ChAPs), a group of4 related, interacting proteins (Bch1p, Fmp50p,Bud7p, Chs6p) that mediate export of specificcargo proteins, including chitin synthaseChs3p, from the Golgi to plasma membrane 0.005020.21249&radic&radic&radic S000000427TDP1YBR223CverifiedTyrosyl-DNA Phosphodiesterase I, hydrolyzes 3'-phosphotyrosylbonds to generate 3'-phosphate DNA andtyrosine, involved in the repair of DNA lesionscreated by topoisomerase I 0.00490.20962&radic&radic&radic&radic S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling 0.004890.20748&radic&radic&radic&radic&radic&radic S000004247YLR257WUncharacterizedHypothetical protein 0.004870.20748&radic&radic&radic&radic&radic S000000832CHZ1YER030WuncharacterizedPutative chaperone for Htz1p/H2A-H2B dimer 0.004830.20684&radic&radic&radic&radic&radic&radic&radic S000004812CLN1YMR199WverifiedG1 cyclin involved in regulation of the cell cycle; activatesCdc28p kinase to promote the G1 to S phasetransition; late G1 specific expression dependson transcription factor complexes, MBF(Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) 0.00480.20636&radic&radic&radic&radic S000004623MAC1YMR021CverifiedCopper-sensing transcription factor involved in regulation ofgenes required for high affinity coppertransport 0.004790.20636&radic&radic&radic&radic&radic&radic&radic S000004005BRE2YLR015WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres;involved in telomere maintenance; similar totrithorax-group protein ASH2L 0.004770.20509&radic&radic&radic&radic&radic S000005954YPL033CUncharacterizedHypothetical protein 0.004670.20152&radic&radic S000004897YKU70YMR284WverifiedSubunit of the telomeric Ku complex (Yku70p-Yku80p), involvedin telomere length maintenance, structure andtelomere position effect; relocates to sites ofdouble-strand cleavage to promote nonhomologousend joining during DSB repair 0.004630.20152&radic&radic&radic&radic&radic&radic S000002907LCD1YDR499WverifiedEssential protein required for the DNA integrity checkpointpathways; interacts physically with Mec1p;putative homolog of S. pombe Rad26 and humanATRIP 0.004640.20152&radic&radic S000004657STB2YMR053CverifiedProtein that interacts with Sin3p in a two-hybrid assay and ispart of a large protein complex with Sin3p andStb1p 0.004680.20152&radic S000004443LEU3YLR451WverifiedZinc-finger transcription factor that regulates genes involvedin branched chain amino acid biosynthesis andammonia assimilation; positively regulated byalpha-isopropylmalate, an intermediate inleucine biosynthesis 0.004620.20152&radic&radic&radic&radic S000000830MIG3YER028CverifiedProbable transcriptional repressor involved in response totoxic agents such as hydroxyurea that inhibitribonucleotide reductase; phosphorylation bySnf1p or the Mec1p pathway inactivates Mig3p,allowing induction of damage response genes 0.004710.20152&radic&radic&radic&radic&radic&radic S000000566MRC1YCL061CverifiedS-phase checkpoint protein found at replication forks, requiredfor DNA replication; also required for Rad53pactivation during DNA replication stress, whereit forms a replication-pausing complex withTof1p and is phosphorylated by Mec1p; proteininvolved in replication checkpoint 0.004730.20152&radic&radic&radic&radic&radic&radic S000001224SVP26YHR181WverifiedIntegral membrane protein of the early Golgi apparatus andendoplasmic reticulum, involved in COP IIvesicle transport; may also function to promoteretention of proteins in the early Golgicompartment 0.004640.20152 S000005366TOP1YOL006CverifiedTopoisomerase I, nuclear enzyme that relieves torsional strainin DNA by cleaving and re-sealing thephosphodiester backbone; relaxes bothpositively and negatively supercoiled DNA;functions in replication, transcription, andrecombination 0.004610.20048&radic&radic&radic&radic&radic S000005335POP2YNR052CverifiedRNase of the DEDD superfamily, subunit of the Ccr4-Not complexthat mediates 3' to 5' mRNA deadenylation 0.004550.19891 S000002632HTB1YDR224CverifiedOne of two nearly identical (see HTB2) histone H2B subtypesrequired for chromatin assembly and chromosomefunction; Rad6p-Bre1p-Lge1p mediatedubiquitination regulates transcriptionalactivation, meiotic DSB formation and H3methylation 0.004540.19891&radic&radic&radic&radic&radic&radic S000002651PRP28YDR243CverifiedRNA helicase in the DEAD-box family, involved in RNAisomerization at the 5' splice site 0.00450.19757&radic&radic&radic&radic&radic&radic S000005834SLY41YOR307CverifiedProtein involved in ER-to-Golgi transport 0.004470.19741&radic&radic&radic S000002719TFB1YDR311WverifiedSubunit of TFIIH and nucleotide excision repair factor 3complexes, required for nucleotide excisionrepair, target for transcriptional activators 0.004450.19651&radic&radic&radic&radic&radic S000005236PUS4YNL292WverifiedPseudouridine synthase, catalyzes only the formation ofpseudouridine-55 (Psi55), a highly conservedtRNA modification, in mitochondrial andcytoplasmic tRNAs; PUS4 overexpression leads totranslational derepression of GCN4 (Gcd-phenotype) 0.00430.19244&radic&radic&radic&radic&radic&radic&radic S000000823RPN3YER021WverifiedEssential, non-ATPase regulatory subunit of the 26S proteasomelid, similar to the p58 subunit of the human26S proteasome; temperature-sensitive allelescause metaphase arrest, suggesting a role forthe proteasome in cell cycle control 0.004340.19244&radic&radic&radic&radic&radic S000000097ECM15YBL001CverifiedNon-essential protein of unknown function, likely exists astetramer, may be regulated by the binding ofsmall-molecule ligands (possibly sulfate ions),may have a role in yeast cell-wall biogenesis 0.00420.18913&radic&radic&radic&radic&radic&radic S000004163YLR173WUncharacterizedHypothetical protein 0.004170.18913&radic&radic&radic&radic&radic&radic S000004675TVP18YMR071CverifiedIntegral membrane protein localized to late Golgi vesiclesalong with the v-SNARE Tlg2p 0.004170.18913 S000005882GDS1YOR355WverifiedProtein of unknown function, required for growth on glycerol asa carbon source; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.004210.18913&radic&radic&radic&radic&radic&radic S000001163LSM12YHR121WverifiedProtein of unknown function that interacts with Pbp1p and Pbp4pand associates with ribosomes; contains anRNA-binding LSM domain and an AD domain; mayplay a role in RNA processing 0.003950.18179&radic&radic&radic&radic&radic&radic S000006177CLN2YPL256CverifiedG1 cyclin involved in regulation of the cell cycle; activatesCdc28p kinase to promote the G1 to S phasetransition; late G1 specific expression dependson transcription factor complexes, MBF(Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) 0.004080.18179&radic&radic&radic&radic&radic&radic S000004126TIS11YLR136CverifiedmRNA-binding protein expressed during iron starvation; binds toa sequence element in the 3'-untranslatedregions of specific mRNAs to mediate theirdegradation; involved in iron homeostasis 0.004030.18179&radic&radic&radic&radic&radic S000005201SIP3YNL257CverifiedProtein that activates transcription through interaction withDNA-bound Snf1p, C-terminal region has aputative leucine zipper motif; potential Cdc28psubstrate 0.004150.18179&radic&radic S000001611PMU1YKL128CverifiedPutative phosphomutase, contains a region homologous to theactive site of phsophomutases; overexpressionof the gene suppresses the histidine auxotrophyof an ade3 ade16 ade17 triple mutant and thetemperature sensitivity of a tps2 mutant 0.004050.18179&radic&radic&radic&radic&radic&radic S000002817SIZ1YDR409WverifiedSUMO ligase that promotes the attachment of sumo (Smt3p; smallubiquitin-related modifier) to proteins; bindsUbc9p and may bind septins; specificallyrequired for sumoylation of septins in vivo;localized to the septin ring 0.003950.18179&radic&radic&radic&radic&radic S000005599SGO1YOR073WverifiedComponent of the spindle checkpoint, involved in sensing lackof tension on mitotic chromosomes; protectscentromeric Rec8p at meiosis I; required foraccurate chromosomal segregation at meiosis IIand for mitotic chromosome stability 0.003990.18179&radic&radic&radic&radic&radic&radic S000004891YMR278WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR278W is not an essential gene 0.003950.18179&radic&radic&radic&radic&radic S000005251MCK1YNL307CverifiedProtein serine/threonine/tyrosine (dual-specificity) kinaseinvolved in control of chromosome segregationand in regulating entry into meiosis; relatedto mammalian glycogen synthase kinases of theGSK-3 family 0.004160.18179&radic&radic&radic&radic S000001909IOC3YFR013WverifiedMember of a complex (Isw1a) with Isw1p that hasnucleosome-stimulated ATPase activity andrepresses transcription initiation by specificpositioning of a promoter proximaldinucleosome; has homology to Esc8p, which isinvolved in silencing 0.004140.18179&radic&radic&radic&radic&radic&radic&radic&radic S000002814PDR15YDR406WverifiedATP binding cassette (ABC) transporter of the plasma membrane;general stress response factor implicated incellular detoxification; target of Pdr1p, Pdr3pand Pdr8p transcription regulators; promotercontains a PDR responsive element 0.003960.18179&radic&radic&radic&radic S000005162MGS1YNL218WverifiedProtein with DNA-dependent ATPase and ssDNA annealingactivities involved in maintenance of genome;interacts functionally with DNA polymerasedelta; homolog of human Werner helicaseinteracting protein (WHIP) 0.003960.18179&radic&radic&radic&radic&radic S000003705YJL169WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2 0.003970.18179&radic&radic&radic&radic&radic S000004106MSL5YLR116WverifiedComponent of the commitment complex, which defines the firststep in the splicing pathway; essential proteinthat interacts with Mud2p and Prp40p, forming abridge between the intron ends; also involvedin nuclear retention of pre-mRNA 0.004020.18179&radic&radic&radic&radic&radic&radic S000006210ICL2YPR006Cverified2-methylisocitrate lyase of the mitochondrial matrix, functionsin the methylcitrate cycle to catalyze theconversion of 2-methylisocitrate to succinateand pyruvate; ICL2 transcription is repressedby glucose and induced by ethanol 0.00390.18042 S000005429HST1YOL068CverifiedNAD(+)-dependent histone deacetylase; essential subunit of theSum1p/Rfm1p/Hst1p complex required forORC-dependent silencing and mitotic repression;non-essential subunit of the Set3C deacetylasecomplex; involved in telomere maintenance 0.003860.17911&radic&radic&radic&radic&radic&radic S000006302YPR098CVerifiedProtein of unknown function, localized to the mitochondrial outer membrane 0.003840.17911 S000000846ERG28YER044CverifiedEndoplasmic reticulum membrane protein, may facilitateprotein-protein interactions between the Erg26pdehydrogenase and the Erg27p 3-ketoreductaseand/or tether these enzymes to the ER, alsointeracts with Erg6p 0.003820.17882&radic&radic&radic&radic S000004125SLX4YLR135WverifiedSubunit of a complex, with Slx1p, that hydrolyzes 5' branchesfrom duplex DNA in response to stalled orconverging replication forks; function overlapswith that of Sgs1p-Top3p &radic0.003830.17882&radic&radic&radic&radic&radic&radic S000003494BUD32YGR262CverifiedProtein kinase proposed to be involved in bud-site selection,telomere uncapping and elongation, andtranscription; component of the EKC/KEOPSprotein complex with Kae1p, Cgi121p, Pcc1p, andGon7p 0.003830.17882&radic&radic&radic&radic&radic S000003674TIF2YJL138CverifiedTranslation initiation factor eIF4A, identical to Tif1p;DEA(D/H)-box RNA helicase that couples ATPaseactivity to RNA binding and unwinding; forms adumbbell structure of two compact domainsconnected by a linker; interacts with eIF4G 0.003820.17882&radic&radic&radic S000004000TEN1YLR010CverifiedProtein that regulates telomeric length; protects telomericends in a complex with Cdc13p and Stn1p 0.00380.17781&radic&radic&radic S000000699YCR102CUncharacterizedPutative protein of unknown function; involved in copper metabolism; similar to C.carbonum toxD gene; YCR102C is not an essential gene 0.00380.17781&radic&radic&radic&radic S000005437BRX1YOL077CverifiedNucleolar protein, constituent of 66S pre-ribosomal particles;depletion leads to defects in rRNA processingand a block in the assembly of large ribosomalsubunits; possesses a sigma(70)-likeRNA-binding motif 0.003790.17762&radic&radic&radic&radic&radic S000004395SFP1YLR403WverifiedTranscription factor that controls expression of many ribosomebiogenesis genes in response to nutrients andstress, regulates G2/M transitions duringmitotic cell cycle and DNA-damage response,involved in cell size modulation 0.003760.17601&radic&radic&radic&radic S000003944SPA2YLL021WverifiedComponent of the polarisome, which functions in actincytoskeletal organization during polarizedgrowth; acts as a scaffold for Mkk1p and Mpk1pcell wall integrity signaling components;potential Cdc28p substrate 0.003770.17601&radic&radic&radic&radic S000005985CWC27YPL064CverifiedComponent of a complex containing Cef1p, putatively involved inpre-mRNA splicing; has similarity to S. pombeCwf27p 0.003760.17601&radic&radic&radic&radic&radic S000002664CTA1YDR256CverifiedCatalase A, breaks down hydrogen peroxide in the peroxisomalmatrix formed by acyl-CoA oxidase (Pox1p)during fatty acid beta-oxidation 0.003690.1751&radic&radic&radic&radic S000000104HIR1YBL008WverifiedNon-essential transcriptional corepressor involved in the cellcycle-regulated transcription of histone H2A,H2B, H3 and H4 genes; contributes to nucleosomeformation, heterochromatic gene silencing, andformation of functional kinetochores 0.003690.1751&radic&radic&radic&radic&radic S000005735NPT1YOR209CverifiedNicotinate phosphoribosyltransferase, acts in the salvagepathway of NAD+ biosynthesis; required forsilencing at rDNA and telomeres and has a rolein silencing at mating-type loci; localized tothe nucleus 0.003710.1751&radic&radic&radic&radic S000001133MSR1YHR091CverifiedMitochondrial arginyl-tRNA synthetase 0.003670.17383&radic&radic&radic&radic&radic S000001222OYE2YHR179WverifiedWidely conserved NADPH oxidoreductase containing flavinmononucleotide (FMN), homologous to Oye3p withslight differences in ligand binding andcatalytic properties; may be involved in sterolmetabolism 0.003670.17383&radic&radic&radic&radic&radic&radic&radic S000000776RML2YEL050CverifiedMitochondrial ribosomal protein of the large subunit, hassimilarity to E. coli L2 ribosomal protein;fat21 mutant allele causes inability to utilizeoleate and may interfere with activity of theAdr1p transcription factor 0.003650.17322&radic&radic&radic&radic&radic&radic&radic S000003507RTT102YGR275WverifiedComponent of both the SWI/SNF and RSC chromatin remodelingcomplexes, suggested role in chromosomemaintenance; possible weak regulator of Ty1transposition 0.003610.17168&radic&radic&radic&radic&radic&radic S000006383HDA3YPR179CverifiedSubunit of a possibly tetrameric trichostatin A-sensitive classII histone deacetylase complex that contains anHda1p homodimer and an Hda2p-Hda3p heterodimer;required for the activity of the complex; hassimilarity to Hda2p 0.003530.16815&radic&radic&radic S000000099HTA2YBL003CverifiedOne of two nearly identical (see also HTA1) histone H2Asubtypes; core histone required for chromatinassembly and chromosome function; DNAdamage-dependent phosphorylation by Mec1pfacilitates DNA repair; acetylated by Nat4p 0.00350.16815&radic&radic&radic&radic&radic&radic S000006230ATH1YPR026WverifiedAcid trehalase required for utilization of extracellulartrehalose 0.003520.16815 S000001127IPI1YHR085WverifiedProtein of unknown function, essential for viability, may beinvolved in rRNA processing 0.003580.16815&radic&radic&radic S000000262UBP14YBR058CverifiedUbiquitin-specific protease that specifically disassemblesunanchored ubiquitin chains; involved infructose-1,6-bisphosphatase (Fbp1p)degradation; similar to human isopeptidase T 0.003490.16815&radic&radic S000005970DIG1YPL049CverifiedRegulatory protein of unknown function,constitutively-expressed, involved in theregulation of mating-specific genes and theinvasive growth pathway, required forMAP-kinase imposed repression, inhibitspheromone-responsive transcription 0.003470.1677&radic&radic&radic&radic&radic S000004410CDC73YLR418CverifiedConstituent of Paf1 complex with RNA polymerase II, Paf1p,Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinctfrom Srb-containing Pol II complexes; requiredfor expression of certain genes, modificationof some histones, and telomere maintenance 0.003460.1677&radic&radic S000001288IRR1YIL026CverifiedSubunit of the cohesin complex, which is required for sisterchromatid cohesion during mitosis and meiosisand interacts with centromeres and chromosomearms, essential for viability 0.00340.16453&radic&radic&radic S000004346TAL1YLR354CverifiedTransaldolase, enzyme in the non-oxidative pentose phosphatepathway; converts sedoheptulose 7-phosphate andglyceraldehyde 3-phosphate to erythrose4-phosphate and fructose 6-phosphate 0.003380.16453&radic&radic S000005976LGE1YPL055CverifiedProtein of unknown function; null mutant forms abnormally largecells 0.003350.16393&radic&radic&radic&radic&radic S000002712CPR5YDR304CverifiedPeptidyl-prolyl cis-trans isomerase (cyclophilin) of theendoplasmic reticulum, catalyzes the cis-transisomerization of peptide bonds N-terminal toproline residues; transcriptionally induced inresponse to unfolded proteins in the ER 0.00330.16257&radic&radic S000000555APA1YCL050CverifiedDiadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4Aphosphorylase), involved in catabolism ofbis(5'-nucleosidyl) tetraphosphates; hassimilarity to Apa2p 0.003280.16192&radic&radic&radic&radic S000003712SWI3YJL176CverifiedSubunit of the SWI/SNF chromatin remodeling complex, whichregulates transcription by remodelingchromosomes; required for transcription of manygenes, including ADH1, ADH2, GAL1, HO, INO1 andSUC2 0.003260.16024&radic&radic&radic&radic S000003698JJJ2YJL162CuncharacterizedProtein of unknown function, contains a J-domain, which is aregion with homology to the E. coli DnaJprotein 0.003260.16024&radic&radic&radic&radic&radic&radic&radic S000006038IDI1YPL117CverifiedIsopentenyl diphosphate:dimethylallyl diphosphate isomerase(IPP isomerase), catalyzes an essentialactivation step in the isoprenoid biosyntheticpathway; required for viability 0.003180.15878&radic&radic&radic&radic&radic&radic S000006215YPR011CUncharacterizedHypothetical protein 0.003190.15878 S000005723MCA1YOR197WverifiedPutative cysteine protease similar to mammalian caspases,involved in regulation of apoptosis uponhydrogen peroxide treatment 0.00320.15878&radic&radic&radic&radic S000002103PMP2YEL017C-AverifiedProteolipid associated with plasma membrane H(+)-ATPase(Pma1p); regulates plasma membrane H(+)-ATPaseactivity; nearly identical to PMP1 0.003190.15878&radic&radic&radic&radic S000005282YNL338WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV 0.003170.15808&radic&radic&radic S000002762TRP4YDR354WverifiedAnthranilate phosphoribosyl transferase of the tryptophanbiosynthetic pathway, catalyzes thephosphoribosylation of anthranilate, subject tothe general control system of amino acidbiosynthesis 0.003170.15808&radic&radic&radic&radic&radic&radic S000006129RKM1YPL208WverifiedSET-domain lysine-N-methyltransferase, catalyzes the formationof dimethyllysine residues on the largeribsomal subunit protein L23a (RPL23A andRPL23B) 0.003110.1561&radic&radic&radic&radic&radic&radic&radic S000004099AHP1YLR109WverifiedThiol-specific peroxiredoxin, reduces hydroperoxides to protectagainst oxidative damage; function in vivorequires covalent conjugation to Urm1p 0.003150.1561&radic&radic&radic&radic&radic&radic S000002653MNN10YDR245WverifiedSubunit of a Golgi mannosyltransferase complex also containingAnp1p, Mnn9p, Mnn11p, and Hoc1p that mediateselongation of the polysaccharide mannanbackbone; membrane protein of themannosyltransferase family 0.00310.1561&radic&radic S000002840NPL3YDR432WverifiedRNA-binding protein that carries poly(A)+ mRNA from the nucleusinto the cytoplasm; phosphorylation by Sky1p inthe cytoplasm may promote release of mRNAs 0.003110.1561&radic&radic&radic S000005670ELG1YOR144CverifiedProtein required for S phase progression and telomerehomeostasis, forms an alternative replicationfactor C complex important for DNA replicationand genome integrity; involved in homologousrecombination-mediated DNA repair 0.003110.1561&radic&radic&radic&radic S000006213SUT2YPR009WverifiedPutative transcription factor; multicopy suppressor ofmutations that cause low activity of thecAMP/protein kinase A pathway; highly similarto Sut1p 0.003140.1561 S000003739PRP21YJL203WverifiedSubunit of the SF3a splicing factor complex, required forspliceosome assembly 0.003090.15427&radic&radic&radic&radic S000005381DIS3YOL021CverifiedNucleolar exosome component, involved in rRNA processing andRNA degradation, binds Gsp1p/Ran and enhancesthe GEF activity of Srm1p, implicated inmitotic control, homologous to the E. coliRNase R of the RNase II family 0.003080.15427&radic&radic&radic S000005565CKB2YOR039WverifiedBeta' regulatory subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKA2 and CKB1, the many substratesinclude transcription factors and all RNApolymerases 0.003040.15257&radic&radic&radic&radic S000003485PUP2YGR253CverifiedAlpha subunit of the 20S proteasome involved inubiquitin-dependent catabolism; human homologis subunit zeta 0.003030.15257&radic&radic&radic&radic&radic&radic S000004618SOK2YMR016CverifiedNuclear protein that plays a regulatory role in the cyclic AMP(cAMP)-dependent protein kinase (PKA) signaltransduction pathway; negatively regulatespseudohyphal differentiation; homologous toseveral transcription factors 0.003010.15257&radic&radic S000000009SWC3YAL011WverifiedProtein of unknown function, component of the SWR1 complex,which exchanges histone variant H2AZ (Htz1p)for chromatin-bound histone H2A; required forformation of nuclear-associated array of smoothendoplasmic reticulum known as karmellae 0.003030.15257&radic&radic&radic&radic&radic&radic S000003201TAN1YGL232WverifiedPutative tRNA acetyltransferase, RNA-binding protein requiredfor the formation of the modified nucleosideN(4)-acetylcytidine in serine and leucine tRNAsbut not required for the same modification in18S rRNA 0.0030.15223&radic&radic&radic&radic&radic S000003196VID30YGL227WverifiedProtein involved in proteasome-dependent catabolite degradationof fructose-1,6-bisphosphatase (FBPase); shiftsthe balance of nitrogen metabolism toward theproduction of glutamate; localized to thenucleus and the cytoplasm 0.002960.14863&radic&radic&radic&radic&radic&radic S000002488PDC2YDR081CverifiedTranscription factor required for the synthesis of theglycolytic enzyme pyruvate decarboxylase,required for high level expression of both theTHI and the PDC genes 0.002970.14863&radic&radic&radic&radic&radic&radic S000006373JIP5YPR169WuncharacterizedNucleolar protein of unknown function, exhibits a physicalinteraction with Bre1p 0.002850.14682&radic&radic&radic&radic&radic S000005949ERG10YPL028WverifiedAcetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase),cytosolic enzyme that transfers an acetyl groupfrom one acetyl-CoA molecule to another,forming acetoacetyl-CoA; involved in the firststep in mevalonate biosynthesis 0.002880.14682&radic&radic&radic&radic&radic S000005098YCK2YNL154CverifiedPalmitoylated, plasma membrane-bound casein kinase I isoform;shares redundant functions with Yck1p inmorphogenesis, proper septin assembly,endocytic trafficking; provides an essentialfunction overlapping with that of Yck1p 0.002880.14682&radic&radic&radic&radic&radic&radic S000001597APN1YKL114CverifiedMajor apurinic/apyrimidinic endonuclease, 3'-repair diesteraseinvolved in repair of DNA damage by oxidationand alkylating agents; also functions as a3'-5' exonuclease to repair7,8-dihydro-8-oxodeoxyguanosine 0.002880.14682&radic&radic&radic&radic&radic S000003335NOP7YGR103WverifiedNucleolar protein involved in rRNA processing and 60S ribosomalsubunit biogenesis; constituent of severaldifferent pre-ribosomal particles; required forexit from G0 and the initiation ofcell proliferation 0.002830.14469&radic&radic&radic&radic&radic&radic S000005587CKA2YOR061WverifiedAlpha' catalytic subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKB1 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.00280.14469&radic&radic&radic&radic&radic&radic&radic S000005639AZF1YOR113WverifiedZinc-finger transcription factor, involved in induction of CLN3transcription in response to glucose; geneticand physical interactions indicate a possiblerole in mitochondrial transcription or genomemaintenance 0.002830.14469&radic&radic&radic&radic&radic&radic S000003162HOS2YGL194CverifiedHistone deacetylase required for gene activation via specificdeacetylation of lysines in H3 and H4 histonetails; subunit of the Set3 complex, ameiotic-specific repressor of sporulationspecific genes that contains deacetylaseactivity 0.002790.14469&radic&radic&radic&radic S000001785YKR077WUncharacterizedPutative transcriptional activator, identified by high-throughput two-hybrid experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YKR077W is not an essential gene 0.00280.14469&radic&radic&radic&radic S000005190VPS75YNL246WverifiedProtein of unknown function involved in vacuolar proteinsorting; detected in the nucleus 0.002840.14469&radic&radic&radic&radic S000001710PAP1YKR002WverifiedPoly(A) polymerase, one of three factors required for mRNA3'-end polyadenylation, forms multiproteincomplex with polyadenylation factor I (PF I),also required for mRNA nuclear export; may alsopolyadenylate rRNAs 0.002830.14469&radic&radic&radic&radic&radic&radic S000004135RMP1YLR145WverifiedEssential component of RNase MRP, which processes pre-rRNA inthe nucleolus and also processes mitochondrialRNAs to create RNA primers for DNA replication 0.00280.14469&radic&radic&radic&radic&radic S000004641CCS1YMR038CverifiedCopper chaperone for superoxide dismutase Sod1p, involved inoxidative stress protection; Met-X-Cys-X2-Cysmotif within the N-terminal portion is involvedin insertion of copper into Sod1p underconditions of copper deprivation 0.002740.14209&radic&radic&radic&radic&radic&radic S000005370RCL1YOL010WverifiedRNA terminal phosphate cyclase-like protein involved in rRNAprocessing at sites A0, A1, and A2; does notpossess detectable RNA cyclase activity 0.002770.14209&radic&radic&radic S000001930PHO4YFR034CverifiedBasic helix-loop-helix (bHLH) transcription factor; bindscooperatively with Pho2p to the PHO5 promoter;function is regulated by phosphorylation atmultiple sites and by phosphate availability 0.002790.14209&radic&radic&radic&radic&radic&radic&radic S000005394SMC5YOL034WverifiedStructural maintenance of chromosomes (SMC) protein; essentialsubunit of the Mms21-Smc5-Smc6 complex;required for growth and DNA repair; S. pombehomolog forms a heterodimer with S. pombeRad18p that is involved in DNA repair 0.002790.14209&radic&radic&radic&radic&radic S000002816ADE8YDR408CverifiedPhosphoribosyl-glycinamide transformylase, catalyzes a step inthe 'de novo' purine nucleotide biosyntheticpathway 0.002720.14124&radic&radic&radic S000004144RNH203YLR154CverifiedRibonuclease H2 subunit, required for RNase H2 activity &radic0.002720.14124&radic&radic&radic&radic&radic&radic&radic S000002506BMH2YDR099Wverified14-3-3 protein, minor isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others 0.00270.14029&radic&radic&radic&radic S000002491TVP23YDR084CuncharacterizedIntegral membrane protein localized to late Golgi vesiclesalong with the v-SNARE Tlg2p; green fluorescentprotein (GFP)-fusion protein localizes to thecytoplasm in a punctate pattern 0.002710.14029&radic&radic&radic&radic S000001897LOC1YFR001WverifiedNuclear protein involved in asymmetric localization of ASH1mRNA; binds double-stranded RNA in vitro;constituent of 66S pre-ribosomal particles 0.00270.14029&radic&radic&radic&radic&radic S000003303YGR071CUncharacterizedPutative protein of unknown function; deletion mutant has increased glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the nucleus 0.002690.13822&radic&radic&radic&radic S000002603REF2YDR195WverifiedRNA-binding protein involved in the cleavage step of mRNA3'-end formation prior to polyadenylation, andin snoRNA maturation; part of holo-CPFsubcomplex APT, which associates with 3'-endsof snoRNA- and mRNA-encoding genes 0.002660.13822&radic&radic&radic&radic S000005372HTZ1YOL012CverifiedHistone variant H2AZ, exchanged for histone H2A in nucleosomesby the SWR1 complex; involved intranscriptional regulation through preventionof the spread of silent heterochromatin 0.002650.13822&radic&radic&radic S000000419HPC2YBR215WverifiedHighly charged, basic protein required for normal cell-cycleregulation of histone gene transcription;mutants display strong synthetic defects withsubunits of FACT, a complex that allows RNA PolII to elongate through nucleosomes 0.002640.13822&radic&radic&radic&radic S000006125HRR25YPL204WverifiedProtein kinase involved in regulating diverse events includingvesicular trafficking, gene expression, DNArepair, and chromosome segregation; binds theCTD of RNA pol II; homolog of mammalian caseinkinase 1delta (CK1delta) 0.002650.13822&radic&radic&radic S000006339CTF4YPR135WverifiedChromatin-associated protein, required for sister chromatidcohesion; interacts with DNA polymerase alpha(Pol1p) and may link DNA synthesis to sisterchromatid cohesion 0.002650.13822&radic&radic&radic S000001441MPH1YIR002CverifiedMember of the DEAH family of helicases, functions in anerror-free DNA damage bypass pathway thatinvolves homologous recombination, mutationsconfer a mutator phenotype 0.00260.13634&radic&radic S000004621STB4YMR019WverifiedProtein that binds Sin3p in a two-hybrid assay; contains aZn(II)2Cys6 zinc finger domain characteristicof DNA-binding proteins 0.00260.13634&radic&radic S000005554CIN5YOR028CverifiedBasic leucine zipper transcriptional factor of the yAP-1 familythat mediates pleiotropic drug resistance andsalt tolerance; localizes constitutively to thenucleus 0.002620.13634&radic&radic&radic&radic&radic S000004349RSC2YLR357WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; involvedin telomere maintenance 0.00260.13634&radic&radic&radic&radic&radic S000005627RAS1YOR101WverifiedGTPase involved in G-protein signaling in the adenylate cyclaseactivating pathway, plays a role in cellproliferation; localized to the plasmamembrane; homolog of mammalian RASproto-oncogenes 0.002640.13634&radic&radic&radic&radic S000002771ESC2YDR363WverifiedProtein involved in mating-type locus silencing, interacts withSir2p; probably functions to recruit orstabilize Sir proteins 0.002630.13634&radic&radic S000005952PHO85YPL031CverifiedCyclin-dependent kinase, with ten cyclin partners; involved inenvironmental stress response; inphosphate-rich conditions, Pho85p-Pho80pcomplex phosphorylates Pho4p which in turnrepresses PHO5 0.002640.13634&radic&radic&radic&radic&radic S000000773YEL047CVerifiedFumurate ReDuctase Soluble 0.002590.13583&radic&radic&radic&radic S000001521RGT1YKL038WverifiedGlucose-responsive transcription factor that regulatesexpression of several glucose transporter (HXT)genes in response to glucose; binds topromoters and acts both as a transcriptionalactivator and repressor 0.002590.13583&radic&radic&radic&radic&radic&radic S000003213RTF1YGL244WverifiedSubunit of the RNA polymerase II-associated Paf1 complex;directly or indirectly regulates DNA-bindingproperties of Spt15p and relative activities ofdifferent TATA elements; involved in telomeremaintenance 0.002590.13583&radic&radic&radic&radic&radic&radic S000004645ARG80YMR042WverifiedTranscription factor involved in regulation ofarginine-responsive genes; acts with Arg81p andArg82p 0.002560.13362&radic&radic&radic&radic&radic S000001249SKN7YHR206WverifiedNuclear response regulator and transcription factor, part of abranched two-component signaling system;required for optimal induction of heat-shockgenes in response to oxidative stress; involvedin osmoregulation 0.002560.13362&radic&radic&radic&radic&radic S000002754SVF1YDR346CverifiedProtein with a potential role in cell survival pathways,required for the diauxic growth shift;expression in mammalian cells increasessurvival under conditions inducing apoptosis 0.002570.13362&radic&radic&radic&radic&radic&radic S000002574TAF10YDR167WverifiedSubunit (145 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification 0.002540.13345&radic&radic&radic&radic&radic&radic S000004889DSK2YMR276WverifiedNuclear-enriched ubiquitin-like polyubiquitin-binding protein,required for spindle pole body (SPB)duplication and for transit through the G2/Mphase of the cell cycle, involved inproteolysis, interacts with the proteasome 0.002530.13209&radic&radic&radic&radic&radic&radic S000005778TMA16YOR252WverifiedProtein of unknown function that associates with ribosomes 0.002520.13209&radic&radic&radic&radic&radic&radic S000000318RAD16YBR114WverifiedProtein that recognizes and binds damaged DNA in anATP-dependent manner (with Rad7p) duringnucleotide excision repair; subunit ofNucleotide Excision Repair Factor 4 (NEF4);member of the SWI/SNF family 0.002510.13209&radic&radic S000005603RTS2YOR077WverifiedBasic zinc-finger protein, similar to human and mouse Kin17proteins which are chromatin-associatedproteins involved in UV response and DNAreplication 0.002520.13209&radic&radic&radic&radic&radic S000005784HNT3YOR258WverifiedMember of the third branch of the histidine triad (HIT)superfamily of nucleotide-binding proteins;similar to Aprataxin, a Hint related proteinthat is mutated in individuals with ataxia withoculomotor apraxia 0.002520.13209&radic&radic&radic&radic&radic S000001069RPN1YHR027CverifiedNon-ATPase base subunit of the 19S regulatory particle of the26S proteasome; may participate in therecognition of several ligands of theproteasome; contains a leucine-rich repeat(LRR) domain, a site for protein?proteininteractions 0.00250.13108&radic S000002615UME6YDR207CverifiedKey transcriptional regulator of early meiotic genes, bindsURS1 upstream regulatory sequence, couplesmetabolic responses to nutritional cues withinitiation and progression of meiosis, formscomplex with Ime1p, and also with Sin3p-Rpd3p 0.002510.13108&radic&radic&radic&radic&radic S000004893CAT8YMR280CverifiedZinc cluster transcriptional activator necessary forderepression of a variety of genes undernon-fermentative growth conditions, activeafter diauxic shift, binds carbon sourceresponsive elements 0.00250.13108&radic&radic&radic&radic&radic&radic S000001697YRA2YKL214CverifiedMember of the REF (RNA and export factor binding proteins)family; when overexpressed, can substitute forthe function of Yra1p in export of poly(A)+mRNA from the nucleus 0.002460.13007&radic&radic&radic&radic S000002761TRR1YDR353WverifiedCytoplasmic thioredoxin reductase, key regulatory enzyme thatdetermines the redox state of the thioredoxinsystem, which acts as a disulfide reductasesystem and protects cells against bothoxidative and reductive stress 0.002480.13007&radic&radic&radic&radic&radic&radic S000003209DOC1YGL240WverifiedProcessivity factor required for the ubiquitination activity ofthe anaphase promoting complex (APC), mediatesthe activity of the APC by contributing tosubstrate recognition; involved in cyclinproteolysis 0.002420.12757&radic&radic&radic S000003478BRF1YGR246CverifiedTFIIIB B-related factor, one of three subunits of RNApolymerase III transcription initiation factorTFIIIB, binds TFIIIC and TBP and recruits RNApol III to promoters, amino-terminal half ishomologous to TFIIB 0.002420.12757&radic&radic&radic&radic&radic S000002969ERG26YGL001CverifiedC-3 sterol dehydrogenase, catalyzes the second of three stepsrequired to remove two C-4 methyl groups froman intermediate in ergosterol biosynthesis 0.002410.12742&radic&radic&radic S000006074RAD53YPL153CverifiedProtein kinase, required for cell-cycle arrest in response toDNA damage; activated by transautophosphorylation when interacting withhyperphosphorylated Rad9p; also interacts withARS1 and plays a role in initiation of DNAreplication 0.00240.12676&radic&radic&radic S000006149CET1YPL228WverifiedBeta (RNA 5'-triphosphatase) subunit of the mRNA cappingenzyme, a heterodimer (the other subunit isCEG1, a guanylyltransferase) involved in addingthe 5' cap to mRNA; the mammalian enzyme is asingle bifunctional polypeptide 0.00240.12676&radic&radic&radic&radic&radic&radic S000004466YAP1YML007WverifiedBasic leucine zipper (bZIP) transcription factor required foroxidative stress tolerance; mediatespleiotropic drug and metal resistance;localized to the nucleus in response to thepresence of oxidants 0.00240.12676&radic&radic&radic S000002315YDL156WUncharacterizedHypothetical protein 0.002390.1263&radic&radic S000000377UMP1YBR173CverifiedShort-lived chaperone required for correct maturation of the20S proteasome; degraded by proteasome uponcompletion of its assembly; involved inubiquitin-mediated proteolysis; mutantdefective in degradation of short-livedproteins 0.002390.1263&radic&radic&radic&radic S000005945RMI1YPL024WverifiedInvolved in response to DNA damage; null mutants have increasedrates of recombination and delayed S phase;interacts physically and genetically with Sgs1p(RecQ family member) and Top3p (topoisomeraseIII) 0.002390.1263&radic&radic&radic&radic S000005992YPL071CUncharacterizedHypothetical protein 0.002380.12556&radic&radic&radic&radic&radic&radic S000001072SLT2YHR030CverifiedSerine/threonine MAP kinase involved in regulating themaintenance of cell wall integrity andprogression through the cell cycle; regulatedby the PKC1-mediated signaling pathway 0.002340.12413&radic&radic&radic&radic&radic&radic S000006012GLR1YPL091WverifiedCytosolic and mitochondrial glutathione oxidoreductase,converts oxidized glutathione to reducedglutathione 0.002360.12413&radic&radic&radic&radic S000005217TOF1YNL273WverifiedSubunit of a replication-pausing checkpoint complex(Tof1p-Mrc1p-Csm3p) that acts at the stalledreplication fork to promote sister chromatidcohesion after DNA damage, facilitating gaprepair of damaged DNA; interacts with the MCMhelicase 0.002360.12413&radic&radic&radic&radic S000002201PRP11YDL043CverifiedSubunit of the SF3a splicing factor complex, required forspliceosome assembly 0.002340.1234&radic&radic S000003959PRP19YLL036CverifiedSplicing factor associated with the spliceosome; contains aU-box, a motif found in a class of ubiquitinligases 0.002340.1234&radic&radic&radic&radic&radic&radic&radic S000001532CSE4YKL049CverifiedCentromere protein that resembles histones, required for properkinetochore function; homolog of human CENP-A 0.002340.1234&radic&radic&radic&radic&radic S000000764UTR4YEL038WverifiedProtein of unknown function, found in both the cytoplasm andnucleus 0.00230.11993&radic&radic&radic&radic&radic&radic S000005733RET1YOR207CverifiedSecond-largest subunit of RNA polymerase III, which isresponsible for the transcription of tRNA and5S RNA genes, and other low molecular weightRNAs 0.002330.11993&radic&radic&radic&radic&radic&radic S000000974BRR2YER172CverifiedRNA-dependent ATPase RNA helicase involved in the facilitationand disruption of snRNA interactions, requiredfor disruption of U4/U6 base-pairing in nativesnRNPs to activate the spliceosome forcatalysis 0.002290.11993&radic&radic S000005897MRS6YOR370CverifiedRab escort protein, forms a complex with the Ras-like smallGTPase Ypt1p that is required for theprenylation of Ypt1p by proteingeranylgeranyltransferase type II (Bet2p-Bet4p) 0.002320.11993&radic&radic&radic&radic&radic S000000886YER084WDubiousHypothetical protein 0.002280.11993&radic&radic&radic&radic&radic&radic S000003412RNR4YGR180CverifiedRibonucleotide-diphosphate reductase (RNR), small subunit; theRNR complex catalyzes the rate-limiting step indNTP synthesis and is regulated by DNAreplication and DNA damage checkpoint pathwaysvia localization of the small subunits 0.002320.11993&radic&radic&radic&radic&radic S000004093CDC45YLR103CverifiedDNA replication initiation factor; recruited to MCM pre-RCcomplexes at replication origins; promotesrelease of MCM from Mcm10p, recruits elongationmachinery; mutants in human homolog may causevelocardiofacial and DiGeorge syndromes 0.002330.11993&radic&radic&radic&radic&radic S000005411GAL11YOL051WverifiedComponent of the Mediator complex; interacts with RNApolymerase II and the general transcriptionfactors to form the RNA polymerase IIholoenzyme; affects transcription by acting astarget of activators and repressors 0.002290.11993&radic&radic&radic&radic S000002829ARO80YDR421WverifiedZinc finger transcriptional activator of the Zn2Cys6 family;activates transcription of aromatic amino acidcatabolic genes in the presence of aromaticamino acids 0.002270.11916&radic&radic&radic&radic&radic&radic S000004791SPT21YMR179WverifiedProtein required for normal transcription at several lociincluding HTA2-HTB2 and HHF2-HHT2, but notrequired at the other histone loci;functionally related to Spt10p; involved intelomere maintenance 0.002270.11916&radic&radic&radic S000000840KRE29YER038CverifiedEssential subunit of the Mms21-Smc5-Smc6 complex; protein ofunknown function; required for growth and DNArepair; heterozygous mutant showshaploinsufficiency in K1 killer toxinresistance 0.002260.11858&radic&radic&radic&radic&radic S000002260CDC2YDL102WverifiedCatalytic subunit of DNA polymerase delta; required forchromosomal DNA replication during mitosis andmeiosis, intragenic recombination, repair ofdouble strand DNA breaks, and DNA replicationduring nucleotide excision repair (NER) 0.002260.11858&radic S000005928TFC8YPL007CverifiedOne of six subunits of RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part ofTFIIIC TauB domain that binds BoxB promotersites of tRNA and other genes; linker betweenTauB and TauA domains; human homolog isTFIIIC-90 0.002230.11458&radic&radic&radic&radic&radic&radic S000005677RPB2YOR151CverifiedRNA polymerase II second largest subunit B150, part of centralcore; similar to bacterial beta subunit 0.002230.11458&radic&radic&radic&radic S000001901SAD1YFR005CverifiedConserved zinc-finger domain protein involved in pre-mRNAsplicing, required for assembly of U4 snRNAinto the U4/U6 particle 0.002220.11458&radic&radic&radic&radic&radic&radic S000004009PSR2YLR019WverifiedFunctionally redundant Psr1p homolog, a plasma membranephosphatase involved in the general stressresponse; required with Psr1p and Whi2p forfull activation of STRE-mediated geneexpression, possibly through dephosphorylationof Msn2p 0.002220.11458&radic&radic&radic S000005420GPD2YOL059WverifiedNAD-dependent glycerol 3-phosphate dehydrogenase, homolog ofGpd1p, expression is controlled by anoxygen-independent signaling pathway requiredto regulate metabolism under anoxic conditions;located in cytosol and mitochondria 0.002220.11458&radic&radic&radic&radic&radic&radic S000006082BEM4YPL161CverifiedProtein involved in establishment of cell polarity and budemergence; interacts with the Rho1p smallGTP-binding protein and with the Rho-typeGTPase Cdc42p; involved in maintenance ofproper telomere length 0.002210.11458&radic&radic&radic S000001932CDC26YFR036WverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 0.00220.11458&radic&radic&radic&radic&radic&radic S000000440ABD1YBR236CverifiedMethyltransferase, catalyzes the transfer of a methyl groupfrom S-adenosylmethionine to the GpppN terminusof capped mRNA 0.00220.11458&radic&radic&radic&radic&radic&radic&radic S000002625RAD9YDR217CverifiedDNA damage-dependent checkpoint protein, required forcell-cycle arrest in G1/S, intra-S, and G2/M;transmits checkpoint signal by activatingRad53p and Chk1p; hyperphosphorylated by Mec1pand Tel1p; potential Cdc28p substrate 0.002190.11429&radic&radic&radic&radic S000005816SNF2YOR290CverifiedCatalytic subunit of the SWI/SNF chromatin remodeling complexinvolved in transcriptional regulation;contains DNA-stimulated ATPase activity;functions interdependently in transcriptionalactivation with Snf5p and Snf6p 0.00220.11429&radic&radic&radic&radic&radic S000006311YTH1YPR107CverifiedEssential RNA-binding component of cleavage and polyadenylationfactor, contains five zinc fingers; requiredfor pre-mRNA 3'-end processing andpolyadenylation 0.002190.11429&radic&radic&radic&radic&radic S000001207DNA2YHR164CverifiedEssential tripartite DNA replication factor withsingle-stranded DNA-dependent ATPase,ATP-dependent nuclease, and helicaseactivities; required for Okazaki fragmentprocessing; involved in DNA repair pathways;potential Cdc28p substrate &radic0.00220.11429&radic&radic&radic&radic&radic&radic&radic S000000448GPX2YBR244WverifiedPhospholipid hydroperoxide glutathione peroxidase induced byglucose starvation that protects cells fromphospholipid hydroperoxides and nonphospholipidperoxides during oxidative stress 0.002180.11334&radic&radic&radic&radic S000003240STF2YGR008CverifiedProtein involved in regulation of the mitochondrial F1F0-ATPsynthase; Stf1p and Stf2p act as stabilizingfactors that enhance inhibitory action of theInh1p protein 0.002180.11334&radic&radic&radic&radic&radic S000001943BNA6YFR047CverifiedQuinolinate phosphoribosyl transferase, required forbiosynthesis of nicotinic acid from tryptophanvia kynurenine pathway 0.002180.11334&radic&radic&radic&radic&radic S000005667ARP8YOR141CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes 0.002180.11334&radic&radic&radic&radic S000002539YDR132CUncharacterizedHypothetical protein 0.002190.11334&radic&radic&radic&radic&radic S000003435YGR203WUncharacterizedPutative protein with sequence similarity to protein tyrosine phosphatases of the CDC25-like phosphatase family; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 0.002170.11227&radic&radic&radic S000003361SYF2YGR129WverifiedComponent of the spliceosome complex involved in pre-mRNAsplicing; involved in regulation of cell cycleprogression 0.002170.11227&radic&radic&radic&radic&radic&radic S000002716SRB7YDR308CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation; target of theglobal repressor Tup1p 0.002170.11227&radic&radic&radic&radic&radic&radic S000005390GAS5YOL030WverifiedPutative 1,3-beta-glucanosyltransferase, has similarity toGas1p; localizes to the cell wall 0.002150.11146&radic&radic&radic&radic&radic&radic S000000763RAD23YEL037CverifiedProtein with ubiquitin-like N terminus, recognizes and bindsdamaged DNA (with Rad4p) during nucleotideexcision repair; regulates Rad4p levels,subunit of Nuclear Excision Repair Factor 2(NEF2); homolog of human HR23A and HR23Bproteins 0.002160.11146&radic&radic&radic&radic S000002545HPR1YDR138WverifiedSubunit of THO/TREX complexes that couple transcriptionelongation with mitotic recombination and withmRNA metabolism and export, subunit of an RNAPol II complex; regulates lifespan; involved intelomere maintenance; similar to Top1p 0.002150.11146&radic&radic&radic S000001933RSC8YFR037CverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; essential for viability andmitotic growth; homolog of SWI/SNF subunitSwi3p, but unlike Swi3p, does not activatetranscription of reporters 0.002160.11146&radic&radic&radic&radic S000000539LSB5YCL034WverifiedProtein of unknown function; binds Las17p, which is a homologof human Wiskott-Aldrich Syndrome proteininvolved in actin patch assembly and actinpolymerization 0.002140.11028&radic&radic&radic&radic&radic S000000745MMS21YEL019CverifiedSUMO ligase involved in chromosomal organization and DNArepair; essential subunit of theMms21-Smc5-Smc6 complex; mutants are sensitiveto methyl methanesulfonate and show increasedspontaneous mutation and mitotic recombination 0.002130.11028&radic&radic&radic&radic&radic&radic&radic S000002584UBC1YDR177WverifiedUbiquitin-conjugating enzyme that mediates selectivedegradation of short-lived and abnormalproteins; plays a role in vesicle biogenesisand ER-associated protein degradation (ERAD);component of the cellular stress response 0.002130.11028&radic&radic&radic&radic&radic S000003269ACB1YGR037CverifiedAcyl-CoA-binding protein, transports newly synthesized acyl-CoAesters from fatty acid synthetase (Fas1p-Fas2p)to acyl-CoA-consuming processes 0.002130.10925&radic&radic&radic&radic&radic&radic S000005234RFC3YNL290WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon 0.002120.10925&radic&radic&radic&radic&radic&radic S000005657YOR131CUncharacterizedHypothetical protein 0.002120.10925&radic&radic&radic S000004603CDC5YMR001CverifiedPolo-like kinase with similarity to Xenopus Plx1 and S. pombePlo1p; found at bud neck, nucleus and SPBs; hasmultiple functions in mitosis and cytokinesisthrough phosphorylation of substrates; may be aCdc28p substrate 0.002110.10771&radic&radic&radic&radic S000000861PCL6YER059WverifiedPho85p cyclin of the Pho80p subfamily; forms the major Glc8pkinase together with Pcl7p and Pho85p; involvedin the control of glycogen storage by Pho85p;stabilized by Elongin C binding 0.00210.10771&radic&radic&radic&radic&radic&radic&radic&radic S000000039CDC24YAL041WverifiedGuanine nucleotide exchange factor (GEF or GDP-release factor)for Cdc42p; required for polarity establishmentand maintenance, and mutants have morphologicaldefects in bud formation and shmooing 0.002070.10684&radic&radic&radic&radic&radic&radic S000001656SNU114YKL173WverifiedGTPase component of U5 snRNP involved in mRNA splicing viaspliceosome; binds directly to U5 snRNA;proposed to be involved in conformationalchanges of the spliceosome; similarity toribosomal translocation factor EF-2 0.002080.10684&radic&radic&radic&radic&radic&radic&radic S000006132NIP7YPL211WverifiedNucleolar protein required for 60S ribosome subunit biogenesis,constituent of 66S pre-ribosomal particles;physically interacts with Nop8p and the exosomesubunit Rrp43p 0.002080.10684&radic&radic&radic&radic&radic S000006391RPO26YPR187WverifiedRNA polymerase subunit ABC23, common to RNA polymerases I, II,and III; part of central core; similar tobacterial omega subunit 0.002060.1055&radic&radic&radic S000006111NAB3YPL190CverifiedSingle stranded DNA binding protein; acidic ribonucleoprotein;required for termination of non-poly(A)transcripts and efficient splicing; interactswith Nrd1p 0.002060.1055&radic&radic&radic&radic&radic S000005159IES2YNL215WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.002060.1055&radic&radic&radic&radic S000004840TAF7YMR227CverifiedTFIID subunit (67 kDa), involved in RNA polymerase IItranscription initiation 0.002040.10444&radic&radic S000001073RRM3YHR031CverifiedDNA helicase involved in rDNA replication and Ty1transposition; relieves replication fork pausesat telomeric regions; structurally andfunctionally related to Pif1p 0.002050.10444&radic&radic&radic&radic&radic S000003323PRP31YGR091WverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.002040.10444&radic S000000446YBR242WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene 0.002040.10444&radic&radic&radic&radic&radic S000005689DDP1YOR163WverifiedDiadenosine polyphosphate hydrolase, member of the MutT familyof nucleotide hydrolases with high specificityfor diadenosine hexa- and pentaphosphates,required for efficient hydrolysis ofdiphosphorylated inositol polyphosphates 0.002030.10404&radic&radic&radic&radic&radic&radic S000006372NUT2YPR168WverifiedComponent of the RNA polymerase II mediator complex, which isrequired for transcriptional activation andalso has a role in basal transcription 0.002020.10299&radic&radic&radic&radic S000004173TOS4YLR183CverifiedTranscription factor that binds to a number of promoterregions, particularly promoters of some genesinvolved in pheromone response and cell cycle;potential Cdc28p substrate; expression isinduced in G1 by bound SBF 0.002020.10299&radic&radic&radic&radic&radic S000005253STB1YNL309WverifiedProtein with a role in regulation of MBF-specific transcriptionat Start, phosphorylated by Cln-Cdc28p kinasesin vitro; unphosphorylated form binds Swi6p andbinding is required for Stb1p function;expression is cell-cycle regulated 0.002020.10299&radic&radic&radic&radic S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.002010.10299&radic&radic&radic S000005428RTG1YOL067CverifiedTranscription factor (bHLH) involved in interorganellecommunication between mitochondria,peroxisomes, and nucleus 0.002030.10299&radic&radic&radic&radic&radic S000004200CLB4YLR210WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the G2/M transition; may beinvolved in DNA replication and spindleassembly; accumulates during S phase and G2,then targeted for ubiquitin-mediateddegradation 0.002010.10299&radic&radic&radic&radic&radic&radic&radic S000005388YAP7YOL028CverifiedPutative basic leucine zipper (bZIP) transcription factor 0.002020.10299&radic&radic&radic&radic&radic S000006046KAP120YPL125WverifiedKaryopherin with a role in the assembly or export of 60Sribosomal subunits 0.002020.10299&radic&radic&radic&radic&radic S000001608RRN3YKL125WverifiedProtein required for transcription of rDNA by RNA polymerase I;transcription factor independent of DNAtemplate; involved in recruitment of RNApolymerase I to rDNA 0.002020.10299&radic&radic&radic&radic&radic&radic S000003464NAS6YGR232WverifiedRegulatory, non-ATPase subunit of the 26S proteasome; homologof the human oncoprotein gankyrin, whichinteracts with the retinoblastoma tumorsuppressor (Rb) and cyclin-dependent kinase 4/6 0.001980.10076&radic&radic&radic&radic S000000869YER067WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YER067W is not an essential gene 0.001980.10076&radic&radic&radic&radic&radic&radic&radic S000001282HIS6YIL020CverifiedPhosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamideisomerase, catalyzes the fourth step inhistidine biosynthesis; mutations causehistidine auxotrophy and sensitivity to Cu, Co,and Ni salts 0.001990.10076&radic&radic&radic&radic&radic S000000064SWD1YAR003WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres; WD40beta propeller superfamily member withsimilarity to mammalian Rbbp7 0.001990.10076&radic&radic&radic&radic&radic&radic S000005564HIR2YOR038CverifiedNon-essential transcriptional corepressor involved in the cellcycle-regulated transcription of histone H2A,H2B, H3, and H4 genes; recruits Swi-Snfcomplexes to histone gene promoters; promotesheterochromatic gene silencing with Asf1p 0.001980.10076&radic&radic&radic&radic&radic S000005700MED4YOR174WverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation 0.001980.10076&radic&radic&radic S000000521DCC1YCL016CverifiedSubunit of a complex with Ctf8p and Ctf18p that shares somecomponents with Replication Factor C, requiredfor sister chromatid cohesion and telomerelength maintenance 0.001970.10064&radic&radic&radic&radic&radic&radic S000002562CPR1YDR155CverifiedCytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin),catalyzes the cis-trans isomerization ofpeptide bonds N-terminal to proline residues;binds the drug cyclosporin A 0.001970.09903&radic&radic&radic S000003038RPB9YGL070CverifiedRNA polymerase II subunit B12.6; contacts DNA; mutations affecttranscription start site; involved in telomeremaintenance 0.001950.09903&radic&radic&radic&radic&radic S000002580ARG82YDR173CverifiedInositol polyphosphate multikinase (IPMK), sequentiallyphosphorylates Ins(1,4,5)P3 to formIns(1,3,4,5,6)P5; putative nuclear lipidinositol PI3-kinase; regulates arginine-,phosphate-, and nitrogen-responsive genes 0.001960.09903&radic&radic&radic&radic&radic S000000122LSM2YBL026WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.001950.09903&radic&radic&radic&radic&radic&radic S000000070ADE1YAR015WverifiedN-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR)synthetase, required for 'de novo' purinenucleotide biosynthesis; red pigmentaccumulates in mutant cells deprived of adenine 0.001970.09903&radic&radic&radic&radic&radic&radic S000004472RAD33YML011CuncharacterizedProtein involved in nucleotide excision repair; greenfluorescent protein (GFP)-fusion proteinlocalizes to the nucleus 0.001960.09903&radic&radic&radic&radic S000001199LIN1YHR156CverifiedNon-essential component of U5 snRNP; nuclear protein;physically interacts with Irr1p of cohesincomplex; may link together proteins involved inchromosome segregation, mRNA splicing and DNAreplication 0.001950.09903&radic&radic&radic&radic&radic&radic S000005549AHC1YOR023CverifiedSubunit of the Ada histone acetyltransferase complex, requiredfor structural integrity of the complex 0.001960.09903&radic&radic&radic&radic&radic&radic S000000098HTB2YBL002WverifiedOne of two nearly identical (see HTB1) histone H2B subtypesrequired for chromatin assembly and chromosomefunction; Rad6p-Bre1p-Lge1p mediatedubiquitination regulates transcriptionalactivation, meiotic DSB formation and H3methylation 0.001920.09697&radic&radic&radic&radic&radic&radic S000002461CDC34YDR054CverifiedUbiquitin-conjugating enzyme or E2; together with Skp1p, Rbx1p,Cdc53p, and an F-box protein, forms aubiquitin-protein ligase called the SCF complexwhich regulates cell cycle progression bytargeting key substrates for degradation 0.001910.09697&radic&radic&radic&radic&radic S000003483YGR251WUncharacterizedPutative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene 0.001930.09697&radic&radic&radic&radic&radic S000005551HST3YOR025WverifiedMember of the Sir2 family of NAD(+)-dependent proteindeacetylases; involved along with Hst4p intelomeric silencing, cell cycle progression,radiation resistance, genomic stability andshort-chain fatty acid metabolism 0.001930.09697&radic&radic&radic S000004049REX2YLR059CverifiedRNA exonuclease, required for U4 snRNA maturation; functionsredundantly with Rnh70p in 5.8S rRNAmaturation, and with Rnh70p and Rex3p inprocessing of U5 snRNA and RNase P RNA; memberof RNase D family of exonucleases 0.001920.09697&radic&radic&radic&radic&radic&radic S000005842SFG1YOR315WverifiedNuclear protein, putative transcription factor required forgrowth of superficial pseudohyphae (which donot invade the agar substrate) but not forinvasive pseudohyphal growth; may act togetherwith Phd1p; potential Cdc28p substrate 0.001920.09697&radic&radic&radic&radic S000005717RIS1YOR191WverifiedMember of the SWI/SNF family of DNA-dependent ATPases, plays arole in antagonizing silencing duringmating-type switching, contains an N-terminaldomain that interacts with Sir4p and aC-terminal SNF2 domain 0.001920.09697&radic&radic&radic&radic&radic S000004208YLR218CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR218C is not essential; mutants exhibit glycogen storage defects and growth defects on a non-fermentable carbon source 0.001910.09697&radic&radic&radic&radic&radic S000004172SWI6YLR182WverifiedTranscription cofactor, forms complexes with DNA-bindingproteins Swi4p and Mbp1p to regulatetranscription at the G1/S transition; involvedin meiotic gene expression; localizationregulated by phosphorylation; potential Cdc28psubstrate 0.001920.09697&radic&radic&radic&radic S000000340MEC1YBR136WverifiedGenome integrity checkpoint protein and PI kinase superfamilymember; signal transducer required for cellcycle arrest and transcriptional responsesprompted by damaged or unreplicated DNA;monitors and participates in meioticrecombination 0.001930.09697&radic S000004169YLR179CUncharacterizedProtein of unknown function, transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus; YLR179C is not essential 0.001910.09697&radic&radic&radic&radic&radic&radic&radic S000004289YHC1YLR298CverifiedComponent of the U1 snRNP complex required for pre-mRNAsplicing; putative ortholog of human U1Cprotein, which is involved in formation of acomplex between U1 snRNP and the pre-mRNA 5'splice site 0.00190.09561&radic&radic&radic&radic S000006382PRP4YPR178WverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.00190.09561&radic&radic&radic S000001146GRE3YHR104WverifiedAldose reductase involved in methylglyoxal, d-xylose andarabinose metabolism; stress induced (osmotic,ionic, oxidative, heat shock, starvation andheavy metals); regulated by the HOG pathway 0.00190.09561&radic&radic&radic&radic&radic&radic S000005124RHO5YNL180CverifiedNon-essential small GTPase of the Rho/Rac subfamily of Ras-likeproteins, likely involved in protein kinase C(Pkc1p)-dependent signal transduction pathwaythat controls cell integrity 0.001890.09561&radic&radic&radic&radic&radic S000001243RPN10YHR200WverifiedNon-ATPase base subunit of the 19S regulatory particle (RP) ofthe 26S proteasome; N-terminus plays a role inmaintaining the structural integrity of the RP;binds selectively to polyubiquitin chains;homolog of the mammalian S5a protein 0.00190.09561&radic&radic&radic&radic&radic S000003682IDS2YJL146WverifiedProtein involved in modulation of Ime2p activity duringmeiosis, appears to act indirectly to promoteIme2p-mediated late meiotic functions; found ingrowing cells and degraded during sporulation 0.001880.09511&radic&radic&radic&radic&radic&radic S000005871TYE7YOR344CverifiedSerine-rich protein that contains a basic-helix-loop-helix(bHLH) DNA binding motif; binds E-boxes ofglycolytic genes and contributes to theiractivation; may function as a transcriptionalactivator in Ty1-mediated gene expression 0.001880.09511&radic&radic&radic&radic&radic&radic S000001647PIR1YKL164CverifiedO-glycosylated protein required for cell wall stability;attached to the cell wall via beta-1,3-glucan;mediates mitochondrial translocation of Apn1p;expression regulated by the cell integritypathway and by Swi5p during the cell cycle 0.001880.09511&radic&radic&radic&radic&radic&radic S000001699URA1YKL216WverifiedDihydroorotate dehydrogenase, catalyzes the fourth enzymaticstep in the de novo biosynthesis ofpyrimidines, converting dihydroorotic acid intoorotic acid 0.001880.09511&radic&radic&radic&radic&radic&radic S000006168YPL247CUncharacterizedHypothetical protein 0.001860.09415&radic&radic&radic S000004966HDA1YNL021WverifiedPutative catalytic subunit of a class II histone deacetylasecomplex that also contains Hda2p and Hda3p;Hda1p interacts with the Hda2p-Hda3p subcomplexto form an active tetramer; deletion increaseshistone H2B, H3 and H4 acetylation 0.001870.09415&radic&radic S000002800SPT3YDR392WverifiedSubunit of the SAGA and SAGA-like transcriptional regulatorycomplexes, interacts with Spt15p to activatetranscription of some RNA polymeraseII-dependent genes, also functions to inhibittranscription at some promoters 0.001860.09415&radic&radic&radic&radic S000004080XDJ1YLR090WverifiedPutative chaperone, homolog of E. coli DnaJ, closely related toYdj1p; the authentic, non-tagged protein isdetected in highly purified mitochondria inhigh-throughput studies 0.001870.09415&radic&radic&radic&radic&radic S000001923ECO1YFR027WverifiedAcetyltransferase required for the establishment of sisterchromatid cohesion during DNA replication, butnot for its maintenance during G2 and M phases;also required for postreplicative double-strandbreak repair; interacts with Chl1p 0.001870.09415&radic&radic&radic&radic&radic S000005361PHO80YOL001WverifiedCyclin, negatively regulates phosphate metabolism;Pho80p-Pho85p (cyclin-CDK complex)phosphorylates Pho4p and Swi5p; deletion ofPHO80 leads to aminoglycoside supersensitivity;truncated form of PHO80 affects vacuoleinheritance 0.001870.09415&radic&radic&radic&radic&radic S000006048HHO1YPL127CverifiedHistone H1, a linker histone required for nucleosome packagingat restricted sites; suppresses DNA repairinvolving homologous recombination; notrequired for telomeric silencing, basaltranscriptional repression, or efficientsporulation 0.001870.09415&radic&radic&radic&radic&radic S000005609WHI5YOR083WverifiedRepressor of G1 transcription that binds to SCB binding factor(SBF) at SCB target promoters in early G1;phosphorylation of Whi5p by the CDK,Cln3p/Cdc28p relieves repression and promoterbinding by Whi5; periodically expressed in G1 0.001850.09324&radic&radic S000001887BLM10YFL007WverifiedProteosome activator subunit; found in association with coreparticles, with and without the 19S regulatoryparticle; required for resistance to bleomycin,may be involved in protecting against oxidativedamage; similar to mammalian PA200 0.001850.09324&radic&radic&radic&radic&radic S000001622CTK1YKL139WverifiedCatalytic (alpha) subunit of C-terminal domain kinase I(CTDK-I), which phosphorylates the C-terminalrepeated domain of the RNA polymerase II largesubunit (Rpo21p) to affect both transcriptionand pre-mRNA 3' end processing 0.001850.09324&radic&radic&radic&radic S000001877GNA1YFL017CverifiedEvolutionarily conserved glucosamine-6-phosphateacetyltransferase required for multiple cellcycle events including passage through START,DNA synthesis, and mitosis; involved inUDP-N-acetylglucosamine synthesis, formsGlcNAc6P from AcCoA 0.001860.09324&radic&radic&radic&radic&radic&radic S000000206RER2YBR002CverifiedCis-prenyltransferase involved in dolichol synthesis;participates in endoplasmic reticulum (ER)protein sorting 0.001840.09144 S000003679TIM17YJL143WverifiedEssential constituent of the mitochondrial inner membranepresequence translocase; interacts with Pam18pto recruit the presequencetranslocase-associated motor (PAM complex) andalso required for protein sorting during import 0.001810.09144&radic&radic&radic&radic&radic&radic&radic S000001676SDS22YKL193CverifiedConserved nuclear regulatory subunit of Glc7p type 1 proteinserine-threonine phosphatase (PP1), functionspositively with Glc7p to promotedephosphorylation of nuclear substratesrequired for chromosome transmission duringmitosis 0.001840.09144&radic&radic&radic&radic&radic S000003704SET2YJL168CverifiedHistone methyltransferase with a role in transcriptionalelongation, methylates a lysine residue ofhistone H3; associates with the C-terminaldomain of Rpo21p; histone methylation activityis regulated by phosphorylation status ofRpo21p 0.001810.09144&radic&radic&radic&radic&radic&radic&radic S000002789YRA1YDR381WverifiedNuclear protein that binds to RNA and to Mex67p, required forexport of poly(A)+ mRNA from the nucleus;member of the REF (RNA and export factorbinding proteins) family; another familymember, Yra2p, can substitute for Yra1pfunction 0.001840.09144&radic&radic&radic&radic S000001672HYM1YKL189WverifiedComponent of the RAM signaling network that is involved inregulation of Ace2p activity and cellularmorphogenesis, interacts with Kic1p and Sog2p,localizes to sites of polarized growth duringbudding and during the mating response 0.001830.09144&radic&radic&radic&radic&radic S000003995SSL1YLR005WverifiedComponent of the core form of RNA polymerase transcriptionfactor TFIIH, which has both protein kinase andDNA-dependent ATPase/helicase activities and isessential for transcription and nucleotideexcision repair; interacts with Tfb4p 0.001820.09144&radic&radic&radic&radic&radic&radic S000001504MAK11YKL021CverifiedProtein essential for cell growth and replication of M dsRNAvirus; contains four beta-transducin repeats 0.001820.09144&radic&radic&radic&radic&radic&radic&radic S000005257YNL313CUncharacterizedProtein required for cell viability 0.001840.09144&radic&radic&radic&radic&radic S000001111RRP4YHR069CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp41p, Rrp42p,Rrp43p and Dis3p 0.001810.09144&radic&radic&radic S000005636TFC7YOR110WverifiedOne of six subunits of the RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part of theTauA globular domain of TFIIIC that binds DNAat the BoxA promoter sites of tRNA and similargenes 0.001820.09144&radic&radic&radic&radic S000005887PDE2YOR360CverifiedHigh-affinity cyclic AMP phosphodiesterase, component of thecAMP-dependent protein kinase signaling system,protects the cell from extracellular cAMP,contains readthrough motif surroundingtermination codon 0.00180.09069&radic&radic&radic&radic S000000401YBR197CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene 0.00180.09069&radic&radic&radic&radic&radic&radic S000002392YDL233WUncharacterizedHypothetical protein 0.00180.09069&radic&radic S000002981PDR1YGL013CverifiedZinc cluster protein that is a master regulator involved inrecruiting other zinc cluster proteins topleiotropic drug response elements (PDREs) tofine tune the regulation of multidrugresistance genes 0.001810.09069&radic&radic&radic&radic&radic&radic S000001128NAM8YHR086WverifiedRNA binding protein, component of the U1 snRNP protein; mutantsare defective in meiotic recombination and information of viable spores, involved in theformation of DSBs through meiosis-specificsplicing of MER2 pre-mRNA 0.001810.09069&radic&radic&radic&radic&radic&radic&radic S000004268YLR278CUncharacterizedZinc-cluster protein; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; YLR278C is not an essential gene 0.00180.09069&radic&radic&radic&radic&radic&radic S000005230CUS2YNL286WverifiedProtein that binds to U2 snRNA and Prp11p, may be involved inU2 snRNA folding; contains two RNA recognitionmotifs (RRMs) 0.00180.09069&radic&radic&radic&radic&radic S000006003MOT1YPL082CverifiedEssential abundant protein involved in regulation oftranscription, removes Spt15p (TBP) from DNAvia its C-terminal ATPase activity, forms acomplex with TBP that binds TATA DNA with highaffinity but with altered specificity 0.00180.09069&radic&radic&radic&radic&radic&radic S000004075ARP6YLR085CverifiedActin-related protein that binds nucleosomes; a component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.001780.08972&radic&radic&radic S000004117APC2YLR127CverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition; similar tocullin Cdc53p 0.001790.08972&radic&radic&radic&radic&radic S000003502YTA7YGR270WverifiedProtein of unknown function, member of CDC48/PAS1/SEC18 familyof ATPases, potentially phosphorylated byCdc28p 0.001790.08972&radic&radic&radic S000004786PAI3YMR174CverifiedCytoplasmic proteinase A inhibitor, dependent on Pbs2p andHog1p protein kinases for osmotic induction;intrinsically unstructured, N-terminal halfbecomes ordered in the active site ofproteinase A upon contact 0.001770.08936&radic&radic&radic&radic&radic&radic S000002643PRP42YDR235WverifiedU1 snRNP protein involved in splicing, required for U1 snRNPbiogenesis; contains multipletetriatricopeptide repeats 0.001770.08826&radic&radic&radic&radic&radic S000002780VPS74YDR372CverifiedNon-essential protein of unknown function involved in vacuolarprotein sorting; belongs to a family ofcytosolic Golgi-associated proteins suggestingthat it may play a role in secretion; alsodetected in the nucleus 0.001760.08826&radic&radic&radic&radic S000005736RPB10YOR210WverifiedRNA polymerase subunit ABC10-beta, common to RNA polymerases I,II, and III 0.001770.08826&radic&radic&radic S000003313SLX9YGR081CverifiedProtein of unknown function; deletion mutant has syntheticfitness defect with an sgs1 deletion mutant 0.001740.08774&radic&radic&radic&radic S000000007SPO7YAL009WverifiedIntegral nuclear/ER membrane protein of unknown function,required for normal nuclear envelope morphologyand sporulation 0.001750.08774&radic&radic&radic&radic&radic&radic S000001195SPO12YHR152WverifiedNucleolar protein of unknown function, positive regulator ofexit from mitosis; involved in regulating therelease of Cdc14p from the nucleolus in earlyanaphase; proposed to play similar role inmeiosis 0.001740.08731&radic&radic&radic&radic&radic&radic&radic S000000187MAP2YBL091CverifiedMethionine aminopeptidase, catalyzes the cotranslationalremoval of N-terminal methionine from nascentpolypeptides; function is partially redundantwith that of Map1p 0.001740.08731&radic&radic&radic&radic S000004261YLR271WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YLR271W is not an essential gene 0.001730.08716&radic&radic&radic&radic&radic&radic&radic S000003249YGR017WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm 0.001730.0863&radic&radic&radic&radic&radic S000001732DBP7YKR024CverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in ribosomal biogenesis 0.001730.0863&radic&radic&radic&radic S000005929CHL1YPL008WverifiedConserved nuclear protein required to establishsister-chromatid pairing during S-phase,probable DNA helicase with similarity to humanBACH1, which associates with tumor suppressorBRCA1; associates with acetyltransferase Ctf7p 0.001730.0863&radic&radic&radic&radic&radic S000002552TAF12YDR145WverifiedSubunit (61/68 kDa) of TFIID and SAGA complexes, involved inRNA polymerase II transcription initiation andin chromatin modification, similar to histoneH2A 0.001720.0863&radic&radic&radic&radic&radic&radic S000004260DCS1YLR270WverifiedNon-essential hydrolase involved in mRNA decapping, mayfunction in a feedback mechanism to regulatedeadenylation, contains pyrophosphataseactivity and a HIT (histidine triad) motif;interacts with neutral trehalase Nth1p 0.001730.0863&radic&radic&radic&radic&radic&radic S000002572TRM82YDR165WverifiedSubunit of a tRNA methyltransferase complex composed of Trm8pand Trm82p that catalyzes 7-methylguanosinemodification of tRNA 0.001710.08532&radic&radic&radic&radic&radic S000006032CAR1YPL111WverifiedArginase, responsible for arginine degradation, expressionresponds to both induction by arginine andnitrogen catabolite repression; disruptionenhances freeze tolerance 0.001720.08532&radic&radic&radic&radic S000001103GIC1YHR061CverifiedProtein of unknown function involved in initiation of buddingand cellular polarization, interacts withCdc42p via the Cdc42/Rac-interactive binding(CRIB) domain 0.00170.08532&radic&radic&radic&radic&radic S000001076PIH1YHR034CverifiedProtein of unresolved function; may function in protein foldingand/or rRNA processing, interacts with achaperone (Hsp82p), two chromatin remodelingfactors (Rvb1p, Rvb2p) and two rRNA processingfactors (Rrp43p, Nop58p) 0.001720.08532&radic&radic&radic&radic&radic&radic S000004377SWC7YLR385CverifiedProtein of unknown function, component of the Swr1p complexthat incorporates Htz1p into chromatin 0.001710.08532&radic&radic&radic&radic&radic S000001359FYV10YIL097WverifiedProtein of unknown function, required for survival uponexposure to K1 killer toxin; involved inproteasome-dependent catabolite inactivation offructose-1,6-bisphosphatase; contains CTLHdomain 0.00170.08501&radic&radic&radic&radic&radic S000000131POL12YBL035CverifiedB subunit of DNA polymerase alpha-primase complex, required forinitiation of DNA replication during mitoticand premeiotic DNA synthesis; also functions intelomere capping and length regulation 0.00170.08501&radic&radic&radic&radic&radic&radic S000001716RSC4YKR008WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; found in close proximity tonucleosomal DNA; displaced from the surface ofnucleosomal DNA after chromatin remodeling 0.00170.08501&radic&radic&radic&radic&radic&radic S000005835SNU66YOR308CverifiedComponent of the U4/U6.U5 snRNP complex involved in pre-mRNAsplicing via spliceosome; has homology to humanSART-1 and to an S. pombe protein; snu66 nullmutation confers cold-sensitivity but is notlethal at normal growth temperatures 0.00170.08501&radic&radic&radic&radic S000000165AST1YBL069WverifiedPeripheral membrane protein that interacts with the plasmamembrane ATPase Pma1p and has a role in itstargeting to the plasma membrane, possibly byinfluencing its incorporation into lipid rafts 0.00170.08491&radic&radic&radic&radic&radic S000004107CLF1YLR117CverifiedEssential splicesome assembly factor; contains multipletetratricopeptide repeat (TPR) protein-bindingmotifs and interacts specifically with manyspliceosome components, may serve as a scaffoldduring splicesome assembly 0.001690.08463&radic&radic&radic&radic&radic&radic&radic S000004320NMA1YLR328WverifiedNicotinic acid mononucleotide adenylyltransferase, involved inNAD(+) salvage pathway 0.001680.08432&radic&radic&radic&radic&radic S000002680GLO2YDR272WverifiedCytoplasmic glyoxalase II, catalyzes the hydrolysis ofS-D-lactoylglutathione into glutathione andD-lactate 0.001670.08375&radic&radic&radic&radic&radic&radic S000005935YPL014WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus 0.001680.08375&radic&radic&radic&radic&radic S000000881YER079WUncharacterizedHypothetical protein 0.001670.08375&radic&radic&radic&radic&radic S000004134ACF2YLR144CverifiedIntracellular beta-1,3-endoglucanase, expression is inducedduring sporulation; may have a role in corticalactin cytoskeleton assembly 0.001680.08375&radic&radic&radic&radic S000000406CDC47YBR202WverifiedComponent of the hexameric MCM complex, which is important forpriming origins of DNA replication in G1 andbecomes an active ATP-dependent helicase thatpromotes DNA melting and elongation whenactivated by Cdc7p-Dbf4p in S-phase 0.001650.0818&radic&radic&radic S000006156RVB2YPL235WverifiedEssential protein involved in transcription regulation;component of chromatin remodeling complexes;required for assembly and function of the INO80complex; member of the RUVB-like protein family 0.001660.0818&radic&radic&radic&radic&radic&radic S000000744EAF5YEL018WuncharacterizedEsa1p-associated factor, subunit of the NuA4 acetyltransferasecomplex 0.001650.0818&radic&radic&radic&radic S000000836YER034WUncharacterizedHypothetical protein 0.001660.0818&radic&radic&radic&radic&radic S000001772OAF3YKR064WuncharacterizedZinc cluster protein of unknown function; the authentic,non-tagged protein is detected in highlypurified mitochondria in high-throughputstudies 0.001650.0818&radic&radic&radic&radic S000004401UTP21YLR409CuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.001650.0818&radic&radic&radic&radic&radic&radic S000005682NFI1YOR156CverifiedSUMO ligase, catalyzes the covalent attachment of SUMO (Smt3p)to proteins; involved in maintenance of propertelomere length 0.001640.0818&radic&radic&radic&radic&radic S000000229YBR025CUncharacterizedHypothetical protein 0.001660.0818&radic S000004745PSO2YMR137CverifiedRequired for a post-incision step in the repair of DNA singleand double-strand breaks that result frominterstrand crosslinks produced by a variety ofmono- and bi-functional psoralen derivatives;induced by UV-irradiation 0.001670.0818&radic S000000441PRP5YBR237WverifiedRNA helicase in the DEAD-box family, necessary forprespliceosome formation, bridges U1 and U2snRNPs and enables stable U2 snRNP associationwith intron RNA 0.001670.0818&radic&radic&radic&radic&radic S000002583NGG1YDR176WverifiedTranscriptional regulator involved in glucose repression ofGal4p-regulated genes; component oftranscriptional adaptor and histoneacetyltransferase complexes, the ADA complex,the SAGA complex, and the SLIK complex 0.001670.0818&radic&radic&radic&radic&radic&radic S000000607POL4YCR014CverifiedDNA polymerase IV, undergoes pair-wise interactions withDnl4p-Lif1p and Rad27p to mediate repair of DNAdouble-strand breaks by non-homologous endjoining (NHEJ); homologous to mammalian DNApolymerase beta 0.001670.0818&radic&radic&radic&radic&radic&radic S000005642RPO31YOR116CverifiedRNA polymerase III subunit C160, part of core enzyme; similarto bacterial beta-prime subunit 0.001650.0818&radic&radic&radic&radic&radic&radic S000006181YPL260WUncharacterizedHypothetical protein 0.001640.08142&radic&radic&radic&radic S000000207COQ1YBR003WverifiedHexaprenyl pyrophosphate synthetase, catalyzes the first stepin ubiquinone (coenzyme Q) biosynthesis 0.001640.08142 S000001091FSH1YHR049WverifiedSerine hydrolase that localizes to both the nucleus andcytoplasm; sequence is similar to Fsh2p andFsh3p 0.001640.08142&radic&radic&radic&radic S000005743RFC1YOR217WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon 0.001640.08142&radic&radic&radic&radic&radic S000003932COX17YLL009CverifiedCopper metallochaperone that transfers copper to Sco1p andCox11p for eventual delivery to cytochrome coxidase 0.001630.08079&radic&radic&radic&radic&radic S000002720SSF2YDR312WverifiedProtein required for ribosomal large subunit maturation,functionally redundant with Ssf1p; member ofthe Brix family 0.001630.08079&radic&radic&radic&radic S000004213IFH1YLR223CverifiedEssential protein with a highly acidic N-terminal domain; IFH1exhibits genetic interactions with FHL1,overexpression interferes with silencing attelomeres and HM loci; potential Cdc28psubstrate 0.001630.08079&radic&radic&radic&radic S000001574YKL091CVerifiedPutative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus 0.001630.08079&radic&radic&radic&radic&radic&radic&radic S000004463GLO1YML004CverifiedMonomeric glyoxalase I, catalyzes the detoxification ofmethylglyoxal (a by-product of glycolysis) viacondensation with glutathione to produceS-D-lactoylglutathione; expression regulated bymethylglyoxal levels and osmotic stress 0.001620.08079&radic&radic&radic&radic&radic S000001946PRE4YFR050Cverified20S proteasome beta-type subunit 0.001630.08079&radic&radic&radic S000005116APC1YNL172WverifiedLargest subunit of the Anaphase-Promoting Complex/Cyclosome(APC/C), which is a ubiquitin-protein ligaserequired for degradation of anaphaseinhibitors, including mitotic cyclins, duringthe metaphase/anaphase transition 0.001630.08079&radic&radic&radic&radic&radic&radic S000002589SAS4YDR181CverifiedSubunit of the SAS complex (Sas2p, Sas4p, Sas5p), whichacetylates free histones and nucleosomes andregulates transcriptional silencing; requiredfor the HAT activity of Sas2p 0.001620.08058&radic&radic&radic&radic&radic S000003383YGR151CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C 0.001620.08058&radic&radic&radic&radic&radic S000001719YKR011CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus 0.001610.07924&radic&radic&radic&radic&radic&radic&radic S000005440REX4YOL080CverifiedPutative RNA exonuclease possibly involved in pre-rRNAprocessing and ribosome assembly 0.001610.07924&radic&radic&radic S000001116QNS1YHR074WverifiedGlutamine-dependent NAD(+) synthetase, essential for theformation of NAD(+) from nicotinic acid adeninedinucleotide 0.001620.07924&radic&radic&radic&radic&radic S000000183RPL23AYBL087CverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl23Bp and has similarity to E.coli L14 and rat L23 ribosomal proteins 0.001610.07924&radic&radic&radic&radic&radic S000003700TPK1YJL164CverifiedSubunit of cytoplasmic cAMP-dependent protein kinase, whichcontains redundant catalytic subunits Tpk1p,Tpk2p, and Tpk3p and regulatory subunit Bcy1p;promotes vegetative growth in response tonutrients; inhibits filamentous growth 0.001620.07924&radic&radic&radic&radic&radic&radic&radic S000002665SET7YDR257CverifiedNuclear protein that contains a SET-domain, which have beenshown to mediate methyltransferase activity inother proteins 0.001620.07924&radic&radic&radic&radic&radic S000000751YEL025CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 0.00160.07924&radic&radic&radic&radic&radic S000001900RPN11YFR004WverifiedMetalloprotease subunit of the 19S regulatory particle of the26S proteasome lid; couples thedeubiquitination and degradation of proteasomesubstrates 0.001620.07924&radic&radic&radic&radic&radic S000001022ECM29YHL030WverifiedMajor component of the proteasome; tethers the proteasome coreparticle to the regulatory particle, andenhances the stability of the proteasome 0.00160.07924&radic&radic&radic&radic&radic&radic S000005392OPI10YOL032WverifiedProtein with a possible role in phospholipid biosynthesis,based on inositol-excreting phenotype of thenull mutant and its suppression by exogenouscholine 0.00160.0792&radic&radic&radic&radic&radic S000000735GCN4YEL009CverifiedTranscriptional activator of amino acid biosynthetic genes inresponse to amino acid starvation; expressionis tightly regulated at both thetranscriptional and translational levels 0.001580.078&radic&radic&radic&radic S000001542MPE1YKL059CverifiedEssential conserved subunit of CPF (cleavage andpolyadenylation factor), plays a role in 3' endformation of mRNA via the specific cleavage andpolyadenylation of pre-mRNA, contains aputative RNA-binding zinc knuckle motif 0.001580.078&radic&radic&radic&radic&radic S000001108SSF1YHR066WverifiedConstituent of 66S pre-ribosomal particles, required forribosomal large subunit maturation;functionally redundant with Ssf2p; member ofthe Brix family 0.001580.078&radic&radic&radic S000006376YPR172WUncharacterizedProtein of unknown function, transcriptionally activated by Yrm1p along with genes involved in multidrug resistance 0.001590.078&radic&radic&radic&radic&radic&radic&radic S000001693UBA1YKL210WverifiedUbiquitin activating enzyme, involved in ubiquitin-mediatedprotein degradation and essential for viability 0.001580.078&radic&radic&radic&radic S000005577YOR051CUncharacterizedNuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts 0.001560.0764&radic&radic&radic&radic&radic S000001511TFA1YKL028WverifiedTFIIE large subunit, involved in recruitment of RNA polymeraseII to the promoter, activation of TFIIH, andpromoter opening 0.001570.0764&radic&radic&radic&radic&radic&radic S000005739SAS5YOR213CverifiedSubunit of the SAS complex (Sas2p, Sas4p, Sas5p), whichacetylates free histones and nucleosomes andregulates transcriptional silencing; stimulatesSas2p HAT activity 0.001570.0764&radic&radic&radic&radic&radic&radic&radic S000005174ELA1YNL230CverifiedElongin A, F-box protein that forms a heterodimer with Elc1pand participates in transcription elongation 0.001570.0764&radic&radic&radic&radic&radic S000004012SDO1YLR022CuncharacterizedEssential protein involved in RNA metabolism, one of two yeasthomologs (with Yhr087wp) of the human proteinSBDS responsible for autosomal recessiveShwachman-Bodian-Diamond Syndrome, alsoconserved in Archaea 0.001560.0764&radic&radic&radic&radic&radic&radic&radic S000001019RIM101YHL027WverifiedTranscriptional repressor involved in response to pH and incell wall construction; required for alkalinepH-stimulated haploid invasive growth andsporulation; activated by proteolyticprocessing; similar to A. nidulans PacC 0.001560.0764&radic&radic&radic&radic S000000125YBL029WUncharacterizedHypothetical protein 0.001560.0764&radic&radic&radic&radic S000002713HNT2YDR305CverifiedDinucleoside triphosphate hydrolase; has similarity to thetumor suppressor FHIT and belongs to thehistidine triad (HIT) superfamily ofnucleotide-binding proteins 0.001560.0764&radic&radic&radic&radic&radic S000004088CHA4YLR098CverifiedDNA binding transcriptional activator, mediatesserine/threonine activation of the catabolicL-serine (L-threonine) deaminase (CHA1);Zinc-finger protein with Zn[2]-Cys[6]fungal-type binuclear cluster domain 0.001530.07345&radic&radic&radic S000003026RAD6YGL058WverifiedUbiquitin-conjugating enzyme (E2), involved in postreplicationrepair (with Rad18p), sporulation, telomeresilencing, and ubiquitin-mediated N-end ruleprotein degradation (with Ubr1p) 0.001540.07345&radic&radic&radic S000001569SRX1YKL086WverifiedSulfiredoxin, contributes to oxidative stress resistance byreducing cysteine-sulfinic acid groups in theperoxiredoxins Tsa1p and Ahp1p that are formedupon exposure to oxidants; conserved in highereukaryotes 0.001510.07345&radic&radic&radic&radic S000002568YDR161WUncharacterizedinteracts with PP2C 0.001530.07345&radic&radic&radic&radic&radic S000005415PSH1YOL054WuncharacterizedNuclear protein, putative RNA polymerase II elongation factor;isolated as Pob3p/Spt16p-binding protein 0.001520.07345&radic&radic&radic&radic S000004821ERG12YMR208WverifiedMevalonate kinase, acts in the biosynthesis of isoprenoids andsterols, including ergosterol, from mevalonate 0.001550.07345&radic&radic&radic S000001250SET5YHR207CverifiedZinc-finger protein of unknown function, contains one canonicaland two unusual fingers in unusualarrangements; deletion enhances replication ofpositive-strand RNA virus 0.001510.07345&radic&radic&radic&radic S000004305SPH1YLR313CverifiedProtein involved in shmoo formation and bipolar bud siteselection; homologous to Spa2p, localizes tosites of polarized growth in a cell cycledependent- and Spa2p-dependent manner,interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p 0.001530.07345&radic&radic&radic&radic S000000449ISW1YBR245CverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPase thatforms a complex with Ioc2p and Ioc4p toregulate transcription elongation, and acomplex with Ioc3p to repress transcriptioninitiation 0.001510.07345&radic&radic&radic S000002482PPH3YDR075WverifiedCatalytic subunit of an evolutionarily conserved proteinphosphatase complex containing Psy2p and theregulatory subunit Psy4p; required forcisplatin resistance; involved in activation ofGln3p 0.001540.07345&radic&radic&radic&radic S000003993YLR003CUncharacterizedPutative protein of unknown function that may participate in DNA replication; green fluorescent protein (GFP)-fusion protein is localized to the nucleus; YLR003C is not an essential gene 0.001510.07345&radic&radic&radic&radic&radic S000004248GSY2YLR258WverifiedGlycogen synthase, similar to Gsy1p; expression induced byglucose limitation, nitrogen starvation, heatshock, and stationary phase; activity regulatedby cAMP-dependent, Snf1p and Pho85p kinases aswell as by the Gac1p-Glc7p phosphatase 0.001510.07345&radic&radic&radic&radic&radic&radic&radic S000001460MRS1YIR021WverifiedProtein required for the splicing of two mitochondrial group Iintrons (BI3 in COB and AI5beta in COX1); formsa splicing complex, containing four subunits ofMrs1p and two subunits of the BI3-encodedmaturase, that binds to the BI3 RNA 0.001520.07345&radic&radic S000005150RTT106YNL206CverifiedProtein with a role in regulation of Ty1 transposition 0.001520.07345&radic&radic&radic&radic S000002458YDR051CUncharacterizedHypothetical protein 0.001530.07345&radic&radic&radic&radic&radic S000001906UBP6YFR010WverifiedUbiquitin-specific protease situated in the base subcomplex ofthe 26S proteasome, releases free ubiquitinfrom branched polyubiquitin chains; deletioncauses hypersensitivity to cycloheximide andother toxic compounds 0.001520.07345&radic&radic S000000292POL30YBR088CverifiedProliferating cell nuclear antigen (PCNA), functions as thesliding clamp for DNA polymerase delta; mayfunction as a docking site for other proteinsrequired for mitotic and meiotic chromosomalDNA replication and for DNA repair 0.001530.07345&radic S000004262YCS4YLR272CverifiedNon-SMC subunit of the condensin complex(Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required forestablishment and maintenance of chromosomecondensation, chromosome segregation, chromatinbinding of condensin and silencing at themating type locus 0.001530.07345&radic&radic&radic&radic&radic&radic S000002510STE5YDR103WverifiedPheromone-responsive scaffold protein; shuttles from thenucleus to the plasma membrane and assembleskinases Ste11p, Ste7p, and Fus3p into aspecific signaling complex; active oligomericform interacts with Ste4p-Ste18p complex 0.00150.07281&radic&radic&radic&radic&radic&radic S000005785RPT4YOR259CverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; required for spindlepole body duplication; localized mainly to thenucleus throughout the cell cycle 0.00150.07281&radic&radic&radic&radic&radic&radic S000004008POM34YLR018CverifiedIntegral membrane protein of the nuclear pore; has an importantrole in maintaining the architecture of thepore complex 0.00150.07281&radic S000001112TRM5YHR070WverifiedtRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacentto the anticodon that has a role in preventionof frameshifting; highly conserved acrossArchaea, Bacteria, and Eukarya 0.00150.07281&radic&radic&radic&radic S000003059NBP35YGL091CverifiedEssential P-loop NTPase that functions in nuclear and cytosoliciron-sulfur (FeS) protein assembly; has ahighly conserved N-terminus 0.00150.07281&radic&radic&radic&radic&radic&radic S000005775APC5YOR249CverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 0.00150.07281&radic&radic&radic&radic&radic&radic S000004007MEU1YLR017WverifiedMethylthioadenosine phosphorylase (MTAP), catalyzes the initialstep in the methionine salvage pathway; affectspolyamine biosynthesis through regulation ofornithine decarboxylase (Spe1p) activity;regulates ADH2 gene expression 0.00150.07281&radic&radic&radic&radic&radic S000003011DST1YGL043WverifiedGeneral transcription elongation factor TFIIS, enables RNApolymerase II to read through blocks toelongation by stimulating cleavage of nascenttranscripts stalled at transcription arrestsites 0.00150.07281&radic&radic&radic&radic S000006394RPC82YPR190CverifiedRNA polymerase III subunit C82 0.001490.0723&radic&radic&radic&radic&radic S000000842GLN3YER040WverifiedTranscriptional activator of genes regulated by nitrogencatabolite repression (NCR), localization andactivity regulated by quality of nitrogensource 0.001490.0723&radic&radic&radic&radic&radic&radic&radic S000003215RAI1YGL246CverifiedNuclear protein that binds to and stabilizes theexoribonuclease Rat1p, required for pre-rRNAprocessing 0.001480.07206&radic&radic&radic&radic&radic S000001763RHO4YKR055WverifiedNon-essential small GTPase of the Rho/Rac subfamily of Ras-likeproteins, likely to be involved in theestablishment of cell polarity 0.001480.07206&radic&radic&radic S000002922YDR514CUncharacterizedHypothetical protein 0.001470.07028&radic S000001585YKL102CDubiousHypothetical protein 0.001470.07028&radic&radic&radic&radic&radic&radic S000005674SPP2YOR148CverifiedEssential protein that promotes the first step of splicing andis required for the final stages of spliceosomematuration; interacts with Prp2p, which mayrelease Spp2p from the spliceosome followingthe first cleavage reaction 0.001480.07028&radic&radic&radic&radic&radic S000001179ARO9YHR137WverifiedAromatic aminotransferase, catalyzes the first step oftryptophan, phenylalanine, and tyrosinecatabolism 0.001470.07028&radic&radic&radic&radic S000000897RAD51YER095WverifiedStrand exchange protein, forms a helical filament with DNA thatsearches for homology; involved in therecombinational repair of double-strand breaksin DNA during vegetative growth and meiosis;homolog of Dmc1p and bacterial RecA protein 0.001480.07028&radic S000003451YGR219WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C 0.001460.07028&radic&radic&radic&radic&radic&radic S000004297UBC12YLR306WverifiedEnzyme that mediates the conjugation of Rub1p, a ubiquitin-likeprotein, to other proteins; related to E2ubiquitin-conjugating enzymes 0.001460.07028&radic&radic&radic S000003306SMD1YGR074WverifiedCore Sm protein Sm D1; part of heteroheptameric complex (withSmb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D1 0.001470.07028&radic&radic&radic&radic&radic S000003726RPS22AYJL190CverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps22Bp and has similarity to E.coli S8 and rat S15a ribosomal proteins 0.001470.07028&radic&radic&radic&radic&radic S000006098CUP9YPL177CverifiedHomeodomain-containing transcriptional repressor of PTR2, whichencodes a major peptide transporter; importedpeptides activate ubiquitin-dependentproteolysis, resulting in degradation of Cup9pand de-repression of PTR2 transcription 0.001480.07028&radic&radic&radic&radic&radic&radic S000000815PRP22YER013WverifiedDEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase,associates with lariat intermediates before thesecond catalytic step of splicing; mediatesATP-dependent mRNA release from the spliceosomeand unwinds RNA duplexes 0.001470.07028&radic&radic&radic&radic&radic&radic S000004391BDF1YLR399CverifiedProtein involved in transcription initiation at TATA-containingpromoters; associates with the basaltranscription factor TFIID; contains twobromodomains; corresponds to the C-terminalregion of mammalian TAF1; redundant with Bdf2p 0.001480.07028&radic&radic&radic&radic S000000115APN2YBL019WverifiedClass II abasic (AP) endonuclease involved in repair of DNAdamage; homolog of human HAP1 and E. coliexoIII 0.001480.07028&radic&radic&radic&radic S000000872RNR1YER070WverifiedRibonucleotide-diphosphate reductase (RNR), large subunit; theRNR complex catalyzes the rate-limiting step indNTP synthesis and is regulated by DNAreplication and DNA damage checkpoint pathwaysvia localization of the small subunits 0.001460.07028&radic&radic&radic&radic&radic S000005857MIP1YOR330CverifiedCatalytic subunit of the mitochondrial DNA polymerase;conserved C-terminal segment is required forthe maintenance of mitochondrial genome. 0.001440.0687&radic&radic&radic&radic S000004413RPN13YLR421CverifiedSubunit of the 19S regulatory particle of the 26S proteasomelid 0.001440.0687&radic&radic&radic&radic&radic&radic S000001873GAT1YFL021WverifiedTranscriptional activator of genes involved in nitrogencatabolite repression, member of the GATAfamily of DNA binding proteins; activity andlocalization regulated by nitrogen limitationand Ure2p 0.001440.0687&radic&radic&radic&radic&radic S000006194SAM4YPL273WverifiedS-adenosylmethionine-homocysteine methyltransferase, functionsalong with Mht1p in the conversion ofS-adenosylmethionine (AdoMet) to methionine tocontrol the methionine/AdoMet ratio 0.001450.0687&radic&radic&radic S000005194RAD50YNL250WverifiedSubunit of MRX complex, with Mre11p and Xrs2p, involved inprocessing double-strand DNA breaks invegetative cells, initiation of meiotic DSBs,telomere maintenance, and nonhomologous endjoining 0.001440.0687&radic S000000844MXR1YER042WverifiedPeptide methionine sulfoxide reductase, reverses the oxidationof methionine residues; involved in oxidativedamage repair, providing resistance tooxidative stress and regulation of lifespan 0.001450.0687&radic&radic&radic&radic&radic&radic&radic S000005664RUP1YOR138CverifiedProtein involved in regulation of Rsp5p, which is an essentialHECT ubiquitin ligase; required for binding ofRsp5p to Ubp2p; contains an UBA domain 0.001440.0687&radic&radic&radic&radic S000004168TFS1YLR178CverifiedCarboxypeptidase Y inhibitor, function requires acetylation bythe NatB N-terminal acetyltransferase;phosphatidylethanolamine-binding proteininvolved in protein kinase A signaling pathway 0.001430.0687&radic&radic&radic S000004639MIH1YMR036CverifiedProtein tyrosine phosphatase involved in cell cycle control;regulates the phosphorylation state of Cdc28p;homolog of S. pombe cdc25 0.001450.0687&radic&radic&radic&radic S000000001TFC3YAL001CverifiedLargest of six subunits of the RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part of theTauB domain of TFIIIC that binds DNA at theBoxB promoter sites of tRNA and similar genes;cooperates with Tfc6p in DNA binding 0.001430.0687&radic&radic&radic&radic S000000120NCL1YBL024WverifiedS-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase,methylates cytosine to m5C at several positionsin tRNAs and intron-containing pre-tRNAs;similar to Nop2p and human proliferationassociated nucleolar protein p120 0.001410.06765&radic&radic&radic&radic S000000150YBL054WUncharacterizedHypothetical protein 0.001420.06765&radic&radic&radic&radic&radic S000001494CCE1YKL011CverifiedMitochondrial cruciform cutting endonuclease, cleaves Hollidayjunctions formed during recombination ofmitochondrial DNA 0.001420.06765 S000000189ROX3YBL093CverifiedRNA polymerase II holoenzyme component 0.001410.06765&radic&radic&radic S000001866CAF16YFL028CverifiedPart of the evolutionarily-conserved CCR4-NOT transcriptionalregulatory complex involved in controlling mRNAinitiation, elongation, and degradation;putative ABC ATPase; interacts with Ssn2p,Ssn3p, and Ssn8p 0.001410.06765&radic&radic&radic&radic&radic S000001383QDR2YIL121WverifiedMultidrug transporter required for resistance to quinidine,barban, cisplatin, and bleomycin; member of themajor facilitator superfamily of transportersconferring multiple drug resistance (MFS-MDR) 0.001420.06765&radic S000003055MMS2YGL087CverifiedProtein involved in error-free postreplication DNA repair;forms a heteromeric complex with Ubc13p thathas a ubiquitin-conjugating activity;cooperates with chromatin-associated RINGfinger proteins, Rad18p and Rad5p 0.001420.06765&radic&radic&radic&radic&radic&radic S000003957RIX7YLL034CverifiedPutative ATPase of the AAA family, required for export ofpre-ribosomal large subunits from the nucleus;distributed between the nucleolus, nucleoplasm,and nuclear periphery depending on growthconditions 0.001420.06765&radic&radic&radic&radic&radic S000005101IGO1YNL157WuncharacterizedHypothetical protein 0.001420.06765&radic&radic&radic&radic&radic S000005683PUP1YOR157CverifiedEndopeptidase with trypsin-like activity that cleaves afterbasic residues; beta-type subunit of 20Sproteasome synthesized as a proprotein beforebeing proteolytically processed for assemblyinto 20S particle; human homolog is subunit Z 0.001410.06712&radic&radic&radic&radic&radic S000001456MET28YIR017CverifiedTranscriptional activator in the Cbf1p-Met4p-Met28p complex,participates in the regulation of sulfurmetabolism 0.00140.06712&radic&radic&radic&radic S000001730NTR2YKR022CverifiedEssential protein that forms a dimer with Ntr1p; also forms atrimer, with Ntr2p and the DExD/H-box RNAhelicase Prp43p, that is involved inspliceosome disassembly 0.00140.06712&radic&radic&radic&radic&radic S000006114RSA1YPL193WverifiedProtein involved in the assembly of 60S ribosomal subunits;functionally interacts with Dbp6p; functions ina late nucleoplasmic step of the assembly 0.001410.06712&radic&radic&radic S000003427SKI6YGR195Wverified3'-to-5' phosphorolytic exoribonuclease that is a subunit ofthe exosome; required for 3' processing of the5.8S rRNA; involved in 3' to 5' mRNAdegradation and translation inhibition ofnon-poly(A) mRNAs 0.00140.06705&radic&radic&radic&radic&radic S000004876SAP30YMR263WverifiedSubunit of a histone deacetylase complex, along with Rpd3p andSin3p, that is involved in silencing attelomeres, rDNA, and silent mating-type loci;involved in telomere maintenance 0.00140.06705&radic&radic&radic&radic&radic&radic S000001495PRP40YKL012WverifiedU1 snRNP protein involved in splicing, interacts with thebranchpoint-binding protein during theformation of the second commitment complex 0.001390.0667&radic&radic&radic&radic&radic S000002480SNF11YDR073WverifiedSubunit of the SWI/SNF chromatin remodeling complex involved intranscriptional regulation; interacts with ahighly conserved 40-residue sequence of Snf2p 0.001390.0667&radic&radic&radic&radic S000003035NPY1YGL067WverifiedNADH diphosphatase (pyrophosphatase), hydrolyzes thepyrophosphate linkage in NADH and relatednucleotides; localizes to peroxisomes 0.001390.0667&radic&radic&radic&radic&radic&radic S000003437YGR205WVerifiedATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases 0.001390.0667&radic&radic&radic&radic&radic S000001751YKR043CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 0.00140.0667&radic&radic&radic S000000456DUT1YBR252WverifieddUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, therebypreventing incorporation of uracil into DNAduring replication; critical for themaintenance of genetic stability 0.001390.0667&radic&radic&radic&radic&radic&radic&radic S000002820RRP17YDR412WuncharacterizedProtein required for cell viability 0.001390.0667&radic&radic&radic&radic&radic&radic&radic S000003242NMA2YGR010WverifiedNicotinic acid mononucleotide adenylyltransferase, involved inNAD(+) salvage pathway 0.001390.06657&radic&radic&radic S000004814RAD14YMR201CverifiedProtein that recognizes and binds damaged DNA during nucleotideexcision repair; subunit of Nucleotide ExcisionRepair Factor 1 (NEF1); contains zinc fingermotif; homolog of human XPA protein 0.001390.06657&radic&radic&radic&radic S000005412SPE2YOL052CverifiedS-adenosylmethionine decarboxylase, required for thebiosynthesis of spermidine and spermine; cellslacking Spe2p require spermine or spermidinefor growth in the presence of oxygen but notwhen grown anaerobically 0.001390.06657&radic&radic&radic&radic&radic S000003508RNH70YGR276Cverified3' exoribonuclease, required for 5S and tRNA-Arg3 maturation 0.001380.06623 S000001652YKL169CDubiousHypothetical protein 0.001380.06623&radic&radic&radic&radic&radic&radic&radic S000005180SIN4YNL236WverifiedSubunit of the Mediator complex; interacts with the RNApolymerase II holoenzyme to postively ornegatively regulate transcription; dispensiblefor basal transcription 0.001380.06623&radic&radic&radic S000002987CKB1YGL019WverifiedBeta regulatory subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKA2 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.001380.06565&radic&radic&radic&radic&radic S000000152PTC3YBL056WverifiedType 2C protein phosphatase; dephosphorylates Hog1p (see alsoPtc2p) to limit maximal kinase activity inducedby osmotic stress; dephosphorylates T169phosphorylated Cdc28p (see also Ptc2p); role inDNA checkpoint inactivation 0.001380.06565&radic&radic&radic&radic&radic&radic S000000682CSM1YCR086WverifiedNucleolar protein that forms a complex with Lrs4p which bindsMam1p at kinetochores during meiosis I tomediate accurate chromosome segregation, may beinvolved in premeiotic DNA replication;possible role in telomere maintenance 0.001370.06565 S000005715IES4YOR189WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.001370.06565&radic&radic S000005365RPB11YOL005CverifiedRNA polymerase II subunit B12.5; part of central core; similarto Rpc19p and bacterial alpha subunit 0.001380.06565&radic&radic S000000864HOR2YER062CverifiedOne of two redundant DL-glycerol-3-phosphatases (RHR2/GPP1encodes the other) involved in glycerolbiosynthesis; induced in response tohyperosmotic stress and oxidative stress, andduring the diauxic transition 0.001380.06565&radic&radic&radic&radic&radic&radic&radic S000001552YKL069WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 0.001360.06505&radic&radic&radic&radic&radic S000002259DUN1YDL101CverifiedCell-cycle checkpoint serine-threonine kinase required for DNAdamage-induced transcription of certain targetgenes, phosphorylation of Rad55p and Sml1p, andtransient G2/M arrest after DNA damage; alsoregulates postreplicative DNA repair 0.001360.06505&radic S000002365YDL206WUncharacterizedHypothetical protein 0.001370.06505&radic S000001454RPR2YIR015WverifiedSubunit of nuclear RNase P, which cleaves tRNA precursors togenerate mature 5' ends; not shared betweenRNase MRP and RNase P, in contrast to all otherRNase P protein subunits &radic0.001370.06505&radic S000005111SKO1YNL167CverifiedBasic leucine zipper (bZIP) transcription factor of theATF/CREB family, forms a complex with Tup1p andSsn6p to both activate and represstranscription; cytosolic and nuclear proteininvolved in osmotic and oxidative stressresponses 0.001360.06505&radic&radic&radic&radic&radic S000000013NTG1YAL015CverifiedDNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involvedin base excision repair, localizes to thenucleus and mitochondrion 0.001360.06505&radic&radic&radic&radic&radic&radic S000003368LSB1YGR136WverifiedProtein containing an N-terminal SH3 domain; binds Las17p,which is a homolog of human Wiskott-AldrichSyndrome protein involved in actin patchassembly and actin polymerization 0.001370.06505&radic&radic&radic&radic S000005688YRR1YOR162CverifiedZn2-Cys6 zinc-finger transcription factor that activates genesinvolved in multidrug resistance; paralog ofYrm1p, acting on an overlapping set of targetgenes 0.001360.06491&radic&radic&radic&radic S000005933RRP12YPL012WverifiedProtein required for export of the ribosomal subunits;associates with the RNA components of thepre-ribosomes; contains HEAT-repeats 0.001350.06423&radic&radic&radic&radic S000005600CDC21YOR074CverifiedThymidylate synthase, required for de novo biosynthesis ofpyrimidine deoxyribonucleotides; expression isinduced at G1/S 0.001350.06423&radic&radic&radic&radic&radic S000002459DBF4YDR052CverifiedRegulatory subunit of Cdc7p-Dbf4p kinase complex, required forCdc7p kinase activity and initiation of DNAreplication; phosphorylates the Mcm2-7 familyof proteins; cell cycle regulated 0.001350.06423&radic&radic&radic&radic&radic S000001001YAP3YHL009CverifiedBasic leucine zipper (bZIP) transcription factor 0.001350.06423&radic&radic&radic&radic&radic&radic S000003276RME1YGR044CverifiedZinc finger protein involved in control of meiosis; preventsmeiosis by repressing IME1 expression andpromotes mitosis by activating CLN2 expression;directly repressed by a1-a2 regulator; mediatescell type control of sporulation 0.001350.06423&radic&radic&radic&radic&radic S000003947SSA2YLL024CverifiedATP binding protein involved in protein folding and vacuolarimport of proteins; member of heat shockprotein 70 (HSP70) family; associated with thechaperonin-containing T-complex; present in thecytoplasm, vacuolar membrane and cell wall 0.001340.06336&radic&radic&radic&radic&radic S000002262QRI7YDL104CuncharacterizedPutative metalloprotease, similar to O-sialoglycoproteinmetallopeptidase from P. haemolytica; theauthentic, non-tagged protein is detected inhighly purified mitochondria in high-throughputstudies 0.001340.06336 S000005873REV1YOR346WverifiedDeoxycytidyl transferase, forms a complex with the subunits ofDNA polymerase zeta, Rev3p and Rev7p; involvedin repair of abasic sites in damaged DNA 0.001340.06336&radic&radic&radic&radic&radic S000003512PXR1YGR280CverifiedEssential protein involved in rRNA and snoRNA maturation;competes with TLC1 RNA for binding to Est2p,suggesting a role in regulation of telomerase;human homolog inhibits telomerase; contains aG-patch RNA interacting domain 0.001330.06336&radic&radic&radic S000005398PRE6YOL038Wverified20S proteasome alpha-type subunit; green fluorescent protein(GFP)-fusion protein relocates from the cytosolto the mitochondrial outer surface uponoxidative stress 0.001340.06336&radic&radic&radic&radic&radic S000001613SHE2YKL130CverifiedRNA-binding protein that binds specific mRNAs and interactswith She3p; part of the mRNA localizationmachinery that restricts accumulation ofcertain proteins to the bud 0.001340.06336&radic&radic&radic&radic&radic S000005846HSH49YOR319WverifiedU2-snRNP associated splicing factor with similarity to themammalian splicing factor SAP49; proposed tofunction as a U2-snRNP assembly factor alongwith Hsh155p and binding partner Cus1p;contains two RNA recognition motifs (RRM) 0.001340.06336&radic&radic&radic&radic&radic S000000797DLD3YEL071WverifiedD-lactate dehydrogenase, part of the retrograde regulon whichconsists of genes whose expression isstimulated by damage to mitochondria andreduced in cells grown with glutamate as thesole nitrogen source, located in the cytoplasm 0.001330.06336&radic&radic&radic&radic&radic&radic S000006347RRP15YPR143WverifiedNucleolar protein, constituent of pre-60S ribosomal particles;required for processing of the 27S pre-rRNA atthe A2 site to yield 5.8S and 25S rRNA 0.001340.06336&radic&radic&radic&radic&radic S000004881PRP24YMR268CverifiedSplicing factor that reanneals U4 and U6 snRNPs duringspliceosome recycling 0.001330.06336&radic&radic&radic&radic&radic&radic S000005643RPT5YOR117WverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; recruited to theGAL1-10 promoter region upon induction oftranscription 0.001320.06297&radic&radic&radic&radic&radic S000000117HAP3YBL021CverifiedSubunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5pCCAAT-binding complex, a transcriptionalactivator and global regulator of respiratorygene expression; contains sequencescontributing to both complex assembly and DNAbinding 0.001320.06297&radic&radic&radic&radic S000001473LYS1YIR034CverifiedSaccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzesthe conversion of saccharopine to L-lysine,which is the final step in the lysinebiosynthesis pathway 0.001320.06273&radic&radic&radic&radic&radic S000003307PRP38YGR075CverifiedUnique component of the U4/U6.U5 tri-snRNP particle,dispensable for spliceosome assembly, butrequired for conformational changes which leadto catalytic activation of the spliceosome 0.001320.06273&radic&radic&radic&radic&radic&radic S000002384SHS1YDL225WverifiedOne of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p,Shs1p) that form a cortical filamentous collarat the mother-bud neck which is necessary fornormal morphogenesis and cytokinesis 0.001320.06273&radic S000004470SPT5YML010WverifiedProtein that forms a complex with Spt4p and mediates bothactivation and inhibition of transcriptionelongation; Spt4p-Spt5p complex also plays arole in pre-mRNA processing 0.001320.06273&radic&radic&radic S000004852RNT1YMR239CverifiedRNAase III; cleaves a stem-loop structure at the 3' end of U2snRNA to ensure formation of the correct U2 3'end &radic0.001320.06273&radic&radic&radic&radic&radic&radic&radic S000003424TDH3YGR192CverifiedGlyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involvedin glycolysis and gluconeogenesis; tetramerthat catalyzes the reaction ofglyceraldehyde-3-phosphate to 1,3bis-phosphoglycerate; detected in the cytoplasmand cell-wall 0.001310.06225&radic&radic&radic&radic&radic&radic S000006010RLM1YPL089CverifiedMADS-box transcription factor, component of the protein kinaseC-mediated MAP kinase pathway involved in themaintenance of cell integrity; phosphorylatedand activated by the MAP-kinase Slt2p 0.001310.06225&radic&radic&radic S000005698YRM1YOR172WverifiedZn2-Cys6 zinc-finger transcription factor that activates genesinvolved in multidrug resistance; paralog ofYrr1p, acting on an overlapping set of targetgenes 0.001310.06225&radic&radic&radic&radic&radic&radic S000001082BCD1YHR040WverifiedEssential protein required for the accumulation of box C/DsnoRNA 0.001310.06225&radic&radic&radic&radic&radic S000001493UFD4YKL010CverifiedUbiquitin-protein ligase (E3) that interacts with Rpt4p andRpt6p, two subunits of the 19S particle of the26S proteasome; cytoplasmic E3 involved in thedegradation of ubiquitin fusion proteins 0.001310.06225&radic&radic&radic&radic&radic S000001515IXR1YKL032CverifiedProtein that binds DNA containing intrastrand cross-linksformed by cisplatin, contains two HMG (highmobility group box) domains, which confer theability to bend cisplatin-modified DNA;mediates aerobic transcriptional repression ofCOX5b 0.00130.06211&radic&radic&radic&radic S000003235CUL3YGR003WverifiedUbiquitin-protein ligase, member of the cullin family withsimilarity to Cdc53p and human CUL3; nullmutation has no apparent phenotype 0.00130.06206&radic&radic&radic&radic&radic&radic S000005140YNL196CUncharacterizedSporulation-specific protein with a leucine zipper motif 0.00130.06206&radic&radic&radic&radic&radic&radic S000004927YMR310CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene 0.00130.0614&radic&radic&radic&radic&radic&radic S000004393DUS3YLR401CuncharacterizedDihydrouridine synthase, member of a widespread family ofconserved proteins including Smm1p, Dus1p, andDus4p; contains a consensus oleate responseelement (ORE) in its promoter region 0.00130.0614&radic&radic&radic&radic S000003804POL32YJR043CverifiedThird subunit of DNA polymerase delta, involved in chromosomalDNA replication; required for error-prone DNAsynthesis in the presence of DNA damage andprocessivity; interacts with Hys2p, PCNA(Pol30p), and Pol1p 0.001290.0614&radic S000006175HFI1YPL254WverifiedAdaptor protein required for structural integrity of the SAGAcomplex, a histoneacetyltransferase-coactivator complex that isinvolved in global regulation of geneexpression through acetylation andtranscription functions 0.001290.0614&radic&radic&radic&radic&radic S000002530INO2YDR123CverifiedComponent of the heteromeric Ino2p/Ino4p basic helix-loop-helixtranscription activator that bindsinositol/choline-responsive elements (ICREs),required for derepression of phospholipidbiosynthetic genes in response to inositoldepletion 0.001290.0614&radic&radic&radic&radic S000003013RIM8YGL045WverifiedProtein of unknown function, involved in the proteolyticactivation of Rim101p in response to alkalinepH; has similarity to A. nidulans PalF 0.001290.06097&radic&radic&radic&radic&radic S000005160RAP1YNL216WverifiedDNA-binding protein involved in either activation or repressionof transcription, depending on binding sitecontext; also binds telomere sequences andplays a role in telomeric position effect(silencing) and telomere structure 0.001290.06097&radic&radic&radic S000001600SBA1YKL117WverifiedCo-chaperone that binds to and regulates Hsp90 familychaperones; important for pp60v-src activity inyeast; homologous to the mammalian p23 proteins 0.001290.06097&radic&radic&radic&radic&radic&radic S000004712YKU80YMR106CverifiedSubunit of the telomeric Ku complex (Yku70p-Yku80p), involvedin telomere length maintenance, structure andtelomere position effect; relocates to sites ofdouble-strand cleavage to promote nonhomologousend joining during DSB repair 0.001280.06079&radic S000001297CKA1YIL035CverifiedAlpha catalytic subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA2, CKB1 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.001280.06079&radic&radic&radic&radic&radic S000005527RRP6YOR001WverifiedExonuclease component of the nuclear exosome; contributes tothe quality-control system that retains anddegrades aberrant mRNAs in the nucleus 0.001280.06079&radic&radic&radic&radic S000003925RTT109YLL002WverifiedProtein with a role in regulation of Ty1 transposition 0.001260.05967&radic&radic&radic&radic&radic S000005225HCH1YNL281WverifiedHeat shock protein regulator that binds to Hsp90p and maystimulate ATPase activity; originallyidentified as a high-copy number suppressor ofa HSP90 loss-of-function mutation; GFP-fusionprotein localizes to the cytoplasm and nucleus 0.001270.05967&radic&radic&radic&radic&radic&radic S000000076YAR028WUncharacterizedPutative integral membrane protein, member of DUP240 gene family 0.001270.05967&radic&radic S000001845SWP82YFL049WuncharacterizedMember of the SWI/SNF chromatin remodeling complex in which itplays an as yet unidentified role; hasidentifiable counterparts in closely relatedyeast species; abundantly expressed in manygrowth conditions; paralog of Npl6p 0.001270.05967&radic&radic&radic S000004905YMR291WUncharacterizedPutative kinase of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR291W is not an essential gene 0.001270.05967&radic&radic&radic&radic S000003275YGR043CUncharacterizedPutative protein of unknown function; transcription is repressed by MOT1/YPL082C and induced by alpha-factor and during diauxic shift; green fluorescent protein (GFP)-fusion protein localizes to the nucleus 0.001280.05967&radic&radic&radic&radic&radic&radic S000003962UBI4YLL039CverifiedUbiquitin, becomes conjugated to proteins, marking them forselective degradation via the ubiquitin-26Sproteasome system; essential for the cellularstress response 0.001270.05967&radic&radic&radic&radic S000005274RPD3YNL330CverifiedHistone deacetylase; regulates transcription and silencing 0.001260.05967&radic&radic&radic&radic S000004871YMR258CUncharacterizedProtein of unknown function with similarity to F-box proteins; physically interacts with Skp1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR258C is not an essential gene 0.001270.05967&radic&radic&radic&radic&radic S000004278RPS30AYLR287C-AverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps30Bp and has similarity to ratS30 ribosomal protein 0.001250.05877&radic&radic&radic S000001221STB5YHR178WverifiedActivator of multidrug resistance genes, forms a heterodimerwith Pdr1p; contains a Zn(II)2Cys6 zinc fingerdomain that interacts with a PDRE (pleotropicdrug resistance element) in vitro; binds Sin3pin a two-hybrid assay 0.001250.05877&radic&radic&radic S000002490RRP8YDR083WverifiedNucleolar protein involved in rRNA processing, pre-rRNAcleavage at site A2; also involved in telomeremaintenance; mutation is synthetically lethalwith a gar1 mutation 0.001250.05877&radic&radic&radic&radic S000003506TAF1YGR274CverifiedTFIID subunit (145 kDa), involved in RNA polymerase IItranscription initiation, has histoneacetyltransferase activity, involved inpromoter binding and G1/S progression 0.001250.05877&radic&radic&radic&radic S000001771LAS1YKR063CverifiedEssential nuclear protein possibly involved in bud formationand morphogenesis; mutants require the SSD1-vallele for viability 0.001240.05877&radic&radic&radic&radic S000002537FIN1YDR130CverifiedSpindle pole body-related intermediate filament protein, formscell cycle-specific filaments between spindlepole bodies in mother and daughter cells, ableto self-assemble, expression induced duringS/G2, localization cell-cycle dependent 0.001250.05877&radic&radic&radic&radic&radic S000002494RRP1YDR087CverifiedEssential evolutionarily conserved nucleolar protein necessaryfor biogenesis of 60S ribosomal subunits andprocessing of pre-rRNAs to mature rRNAs,associated with several distinct 66Spre-ribosomal particles 0.001240.05877&radic&radic&radic S000000784PCM1YEL058WverifiedEssential N-acetylglucosamine-phosphate mutase, ahexosephosphate mutase involved in thebiosynthesis of chitin 0.001250.05877&radic&radic&radic&radic S000001283RPB3YIL021WverifiedRNA polymerase II third largest subunit B44, part of centralcore; similar to prokaryotic alpha subunit 0.001240.05819&radic&radic&radic S000005168SQS1YNL224CverifiedProtein of unknown function; overexpression antagonizes thesuppression of splicing defects by spp382mutants; green fluorescent protein (GFP)-fusionprotein localizes to both the cytoplasm and thenucleus 0.001240.05819&radic&radic&radic S000001789RPF2YKR081CverifiedEssential protein involved in the processing of pre-rRNA andthe assembly of the 60S ribosomal subunit;interacts with ribosomal protein L11; localizespredominantly to the nucleolus; constituent of66S pre-ribosomal particles 0.001240.05819&radic&radic&radic&radic&radic S000003343YGR111WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 0.001240.05819&radic&radic&radic S000003410PBP1YGR178CverifiedProtein interacting with poly(A)-binding protein Pab1p; likelyinvolved in controlling the extent of mRNApolyadenylation; forms a complex with Mkt1pthat may regulate HO translation; interactswith Lsm12p in a copurification assay 0.001240.05819&radic&radic&radic&radic&radic S000005615VPS21YOR089CverifiedGTPase required for transport during endocytosis and forcorrect sorting of vacuolar hydrolases;localized in endocytic intermediates; detectedin mitochondria; geranylgeranylation requiredfor membrane association; mammalian Rab5homolog 0.001240.05819&radic&radic&radic S000003245SNU71YGR013WverifiedComponent of U1 snRNP required for mRNA splicing viaspliceosome; yeast specific, no metazoancounterpart 0.001240.05819&radic&radic&radic&radic S000005167ATG4YNL223WverifiedCysteine protease required for autophagy; cleaves Atg8p to aform required for autophagosome and Cvt vesiclegeneration; mediates attachment ofautophagosomes to microtubules throughinteractions with Tub1p and Tub2p 0.001240.05819&radic&radic S000000824SRB4YER022WverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation 0.001240.05819&radic&radic&radic S000004034PDC1YLR044CverifiedMajor of three pyruvate decarboxylase isozymes, key enzyme inalcoholic fermentation, decarboxylates pyruvateto acetaldehyde; subject to glucose-, ethanol-,and autoregulation; involved in amino acidcatabolism 0.001230.05819&radic&radic&radic&radic S000002769BCP1YDR361CverifiedEssential protein involved in nuclear export of Mss4p, which isa lipid kinase that generatesphosphatidylinositol 4,5-biphosphate and playsa role in actin cytoskeleton organization andvesicular transport 0.001230.05813&radic&radic&radic&radic&radic S000002217RAD59YDL059CverifiedProtein involved in the repair of double-strand breaks in DNAduring vegetative growth via recombination andsingle-strand annealing; anneals complementarysingle-stranded DNA; homologous to Rad52p 0.001230.05813&radic S000005016RNH201YNL072WverifiedRibonuclease H2 catalytic subunit, removes RNA primers duringOkazaki fragment synthesis; cooperates withRad27p nuclease &radic0.001230.05813&radic S000004221BNA5YLR231CverifiedKynureninase, required for biosynthesis of nicotinic acid fromtryptophan via kynurenine pathway 0.001230.05813&radic&radic&radic&radic&radic&radic S000002598RVB1YDR190CverifiedEssential protein involved in transcription regulation;component of chromatin remodeling complexes;required for assembly and function of the INO80complex; member of the RUVB-like protein family 0.001230.05794&radic&radic&radic&radic S000000057YAL061WUncharacterizedputative polyol dehydrogenase 0.001230.05794&radic&radic&radic S000005283YRF1-6YNL339CverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p 0.001220.05735&radic&radic&radic S000000170AAR2YBL074CverifiedComponent of the U5 snRNP, required for splicing of U3precursors; originally described as a splicingfactor specifically required for splicingpre-mRNA of the MATa1 cistron 0.001220.05735&radic&radic&radic&radic&radic S000006358PIN3YPR154WverifiedProtein that induces appearance of [PIN+] prion whenoverproduced 0.001230.05735&radic&radic&radic&radic&radic&radic S000002738UBX5YDR330WuncharacterizedUBX (ubiquitin regulatory X) domain-containing protein thatinteracts with Cdc48p 0.001220.05732&radic&radic&radic&radic S000000129RIB1YBL033CverifiedGTP cyclohydrolase II; catalyzes the first step of theriboflavin biosynthesis pathway 0.001210.05721&radic&radic&radic&radic S000006043TFB2YPL122CverifiedSubunit of TFIIH and nucleotide excision repair factor 3complexes, involved in transcriptioninitiation, required for nucleotide excisionrepair, similar to 52 kDa subunit of humanTFIIH 0.001220.05721&radic&radic&radic&radic S000005176CSL4YNL232WverifiedSubunit of the exosome, which is an essential complex presentin both nucleus and cytoplasm that mediates RNAprocessing and degradation 0.00120.05627&radic&radic&radic&radic S000003279TFC4YGR047CverifiedOne of six subunits of the RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part of theTauA domain of TFIIIC that binds BoxA DNApromoter sites of tRNA and similar genes; hasTPR motifs; human homolog is TFIIIC-102 0.00120.05627&radic&radic&radic&radic&radic&radic S000003465PHO81YGR233CverifiedCyclin-dependent kinase (CDK) inhibitor, regulatesPho80p-Pho85p and Pcl7p-Pho85p cyclin-CDKcomplexes in response to phosphate levels;required for derepression of PHO5;transcriptionally regulated by Pho4p and Pho2p 0.001210.05627&radic&radic&radic&radic S000004365VID22YLR373CverifiedGlycosylated integral membrane protein localized to the plasmamembrane; plays a role infructose-1,6-bisphosphatase (FBPase)degradation; involved in FBPase transport fromthe cytosol to Vid (vacuole import anddegradation) vesicles 0.001210.05627&radic&radic&radic S000000112FUS3YBL016WverifiedMitogen-activated protein kinase involved in mating pheromoneresponse; activated by phosphorylation bySte7p; provides specificity during the matingvs. filamentous growth response byphosphorylating transcriptional and cytoplasmictargets 0.001210.05627&radic&radic&radic&radic S000002812RPB7YDR404CverifiedRNA polymerase II subunit B16; forms two subunit dissociablecomplex with Rpb4p 0.001210.05627&radic&radic S000001595ABF1YKL112WverifiedDNA binding protein with possible chromatin-reorganizingactivity involved in transcriptionalactivation, gene silencing, and DNA replicationand repair 0.00120.05627&radic&radic&radic&radic S000005902GDH1YOR375CverifiedNADP(+)-dependent glutamate dehydrogenase, synthesizesglutamate from ammonia and alpha-ketoglutarate;rate of alpha-ketoglutarate utilization differsfrom Gdh3p; expression regulated by nitrogenand carbon sources 0.001210.05627&radic&radic&radic&radic&radic S000006072PRP46YPL151CverifiedSplicing factor that is found in the Cef1p subcomplex of thespliceosome 0.00120.05627&radic&radic&radic&radic&radic S000000770IES6YEL044WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.001210.05627&radic&radic&radic&radic&radic&radic S000000517GBP2YCL011CverifiedPoly(A+) RNA-binding protein, involved in the export of mRNAsfrom the nucleus to the cytoplasm; similar toHrb1p and Npl3p; also binds single-strandedtelomeric repeat sequence in vitro 0.001210.05627&radic&radic&radic&radic&radic&radic S000000733YEL007WUncharacterizedPutative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) 0.001210.05627&radic&radic&radic&radic&radic&radic S000002565HOM2YDR158WverifiedAspartic beta semi-aldehyde dehydrogenase, catalyzes the secondstep in the common pathway for methionine andthreonine biosynthesis; expression regulated byGcn4p and the general control of amino acidsynthesis 0.001210.05627&radic&radic&radic&radic&radic&radic S000000457SRB6YBR253WverifiedEssentital subunit of the RNA polymerase II mediator complex;associates with core polymerase subunits toform the RNA polymerase II holoenzyme;essential for transcriptional regulation 0.00120.05622&radic&radic&radic&radic&radic S000000432SLX1YBR228WverifiedSubunit of a complex, with Slx4p, that hydrolyzes 5' branchesfrom duplex DNA in response to stalled orconverging replication forks; function overlapswith that of Sgs1p-Top3p &radic0.00120.05622&radic&radic&radic&radic&radic&radic&radic S000003588TDH1YJL052WverifiedGlyceraldehyde-3-phosphate dehydrogenase, isozyme 1, involvedin glycolysis and gluconeogenesis; tetramerthat catalyzes the reaction ofglyceraldehyde-3-phosphate to 1,3bis-phosphoglycerate; detected in the cytoplasmand cell-wall 0.001190.05539&radic S000001498PUT3YKL015WverifiedTranscriptional activator of proline utilization genes,constitutively binds PUT1 and PUT2 promotersequences and undergoes a conformational changeto form the active state; has a Zn(2)-Cys(6)binuclear cluster domain 0.00120.05539&radic&radic&radic&radic&radic&radic S000003329ASK10YGR097WverifiedComponent of the RNA polymerase II holoenzyme, phosphorylatedin response to oxidative stress; has a role indestruction of Ssn8p, which relieves repressionof stress-response genes 0.001190.05539&radic&radic&radic&radic S000004216BUR2YLR226WverifiedCyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2pcomprise a CDK-cyclin complex involved intranscriptional regulation through itsphosphorylation of the carboxy-terminal domainof the largest subunit of RNA polymerase II 0.001190.05539&radic&radic&radic&radic S000005648PFY1YOR122CverifiedProfilin, actin- and phosphatidylinositol4,5-bisphosphate-binding protein, plays a rolein cytoskeleton organization, required fornormal timing of actin polymerization inresponse to thermal stress; localizes to plasmamembrane and cytosol 0.001190.05539&radic&radic&radic&radic S000000379SWD3YBR175WverifiedEssential subunit of the COMPASS (Set1C) complex, whichmethylates histone H3 on lysine 4 and isrequired in transcriptional silencing neartelomeres; WD40 beta propeller superfamilymember and ortholog of mammalian WDR5 0.001190.05539&radic&radic&radic S000004697NPL6YMR091CverifiedComponent of the RSC chromatin remodeling complex; interactswith Rsc3p, Rsc30p, Ldb7p, and Htl1p to form amodule important for a broad range of RSCfunctions; involved in nuclear protein importand maintenance of proper telomere length 0.001190.05539&radic&radic S000000399MSI1YBR195CverifiedSubunit of chromatin assembly factor I (CAF-I), regulates theRAS/cAMP pathway via sequestration of Npr1pkinase; localizes to the nucleus and cytoplasm;homologous to human retinoblastoma bindingproteins RbAp48 and RbAp46 0.001190.05539&radic&radic&radic S000005734PTP2YOR208WverifiedPhosphotyrosine-specific protein phosphatase involved in theinactivation of mitogen-activated proteinkinase (MAPK) during osmolarity sensing;dephosporylates Hog1p MAPK and regulates itslocalization; localized to the nucleus 0.00120.05539&radic&radic&radic&radic&radic&radic S000001778YKR070WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion 0.001180.05447&radic&radic&radic&radic&radic&radic S000000922SCS2YER120WverifiedIntegral ER membrane protein that regulates phospholipidmetabolism via an interaction with the FFATmotif of Opi1p, also involved in telomericsilencing, disruption causes inositolauxotrophy above 34 degrees C, VAP homolog 0.001170.05447&radic S000003440SER2YGR208WverifiedPhosphoserine phosphatase of the phosphoglycerate pathway,involved in serine and glycine biosynthesis,expression is regulated by the availablenitrogen source 0.001170.05447&radic&radic&radic&radic&radic S000003039AFT1YGL071WverifiedTranscription factor involved in iron utilization andhomeostasis; binds the consensus sitePyPuCACCCPu and activates the expression oftarget genes in response to changes in ironavailability 0.001180.05447&radic&radic&radic&radic S000000781POL5YEL055CverifiedProtein with sequence similarity to the human MybBP1A and weaksequence similar to B-type DNA polymerases, notrequired for chromosomal DNA replication;required for the synthesis of rRNA 0.001170.05447&radic&radic&radic&radic S000002525APC4YDR118WverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 0.001170.05447&radic&radic&radic&radic S000001849SEC53YFL045CverifiedPhosphomannomutase, involved in synthesis of GDP-mannose anddolichol-phosphate-mannose; required forfolding and glycosylation of secretory proteinsin the ER lumen 0.001170.05447&radic&radic&radic&radic&radic S000005418YOL057WUncharacterizedPutative metalloprotease 0.001170.05349&radic&radic S000005215BNI1YNL271CverifiedFormin, nucleates the formation of linear actin filaments,involved in cell processes such as budding andmitotic spindle orientation which require theformation of polarized actin cables,functionally redundant with BNR1 0.001150.05349&radic&radic&radic&radic S000004847RNH1YMR234WverifiedRibonuclease H1, removes RNA primers during Okazaki fragmentsynthesis; degrades RNA attached to the 5'-endof a DNA strand &radic0.001170.05349&radic&radic&radic&radic&radic S000000069BUD14YAR014CverifiedProtein involved in bud-site selection, Bud14p-Glc7p complexfunctions as a cortical regulator of dynein;diploid mutants display a random buddingpattern instead of the wild-type bipolarpattern 0.001160.05349&radic&radic&radic&radic&radic S000002948IRC4YDR540CuncharacterizedHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 0.001170.05349&radic&radic&radic S000004313SFH1YLR321CverifiedSubunit of the RSC chromatin remodeling complex required forkinetochore function in chromosome segregation;essential gene required for cell cycleprogression; phosphorylated in the G1 phase ofth