Yfunc lets you browse current and predicted gene functions in yeast

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Prediction of GO:0018193 "peptidyl-amino acid modification"

GO branch: BP
Number of currently annotated genes: 22

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest Parsons:CaffeineHuh:cytoplasmDudley:HygroBHarbison:YNR063W_YPDLum:NicardipineDudley:CaffTAP:200TAP:114Lum:OmeprazoleTAP:87 S000007587KTI11YBL071W-AverifiedProtein required for synthesis of diphthamide, a modifiedhistidine residue of translation elongationfactor 2; functions with Dph1p, Dph2p, Jjj3p,and Dph5p; required, with Elongator complex,for modification of wobble nucleosides in tRNA &radic0.299220.83995&radic S000000779MAK10YEL053CverifiedNon-catalytic subunit of N-terminal acetyltransferase of theNatC type, required for replication of dsRNAvirus; expression is glucose-repressible &radic0.291570.83452&radic&radic&radic&radic&radic S000001674DPH2YKL191WverifiedProtein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p,for synthesis of diphthamide, which is amodified histidine residue of translationelongation factor 2 (Eft1p or Eft2p); may actin a complex with Dph1p and Kti11p &radic0.280010.82616&radic&radic&radic S000005611OST3YOR085WverifiedGamma subunit of the oligosaccharyltransferase complex of theER lumen, which catalyzes asparagine-linkedglycosylation of newly synthesized proteins;Ost3p is important for N-glycosylation of asubset of proteins 0.241210.80014&radic&radic S000001365DPH1YIL103WverifiedProtein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p,for synthesis of diphthamide, which is amodified histidine residue of translationelongation factor 2 (Eft1p or Eft2p); may actin a complex with Dph2p and Kti11p &radic0.224740.78522&radic&radic S000001055ARD1YHR013CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing &radic0.2190.77878&radic&radic&radic&radic&radic&radic S000005779NAT5YOR253WverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing &radic0.178320.74213&radic&radic&radic&radic S000006255MAK3YPR051WverifiedCatalytic subunit of N-terminal acetyltransferase of the NatCtype; required for replication of dsRNA virus &radic0.173720.73478&radic&radic&radic S000000614MAK31YCR020C-AverifiedNon-catalytic subunit of N-terminal acetyltransferase of theNatC type; required for replication of dsRNAvirus; member of the Sm protein family &radic0.167130.72279&radic&radic&radic S000006335NAT3YPR131CverifiedCatalytic subunit of the NatB N-terminal acetyltransferase,which catalyzes acetylation of theamino-terminal methionine residues of allproteins beginning with Met-Asp or Met-Glu andof some proteins beginning with Met-Asn orMet-Met &radic0.130630.67428&radic&radic&radic&radic&radic S000004757SWP1YMR149WverifiedDelta subunit of the oligosaccharyl transferase glycoproteincomplex, which is required for N-linkedglycosylation of proteins in the endoplasmicreticulum 0.108470.63211&radic&radic&radic S000002990STT3YGL022WverifiedSubunit of the oligosaccharyltransferase complex of the ERlumen, which catalyzes asparagine-linkedglycosylation of newly synthesized proteins;forms a subcomplex with Ost3p and Ost4p and isdirectly involved in catalysis 0.10510.62464&radic&radic S000000728WBP1YEL002CverifiedBeta subunit of the oligosaccharyl transferase (OST)glycoprotein complex; required for N-linkedglycosylation of proteins in the endoplasmicreticulum 0.102610.61961&radic S000006007ELP3YPL086CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;exhibits histone acetyltransferase activitythat is directed to histones H3 and H4;disruption confers resistance to K. lactiszymotoxin 0.099630.61668&radic&radic S000002198NAT1YDL040CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing &radic0.090530.598&radic&radic&radic&radic S000003704SET2YJL168CverifiedHistone methyltransferase with a role in transcriptionalelongation, methylates a lysine residue ofhistone H3; associates with the C-terminaldomain of Rpo21p; histone methylation activityis regulated by phosphorylation status ofRpo21p 0.079330.57929&radic S000003486ENO1YGR254WverifiedEnolase I, a phosphopyruvate hydratase that catalyzes theconversion of 2-phosphoglycerate tophosphoenolpyruvate during glycolysis and thereverse reaction during gluconeogenesis;expression is repressed in response to glucose 0.054010.50778&radic&radic S000004722ASC1YMR116CverifiedWD repeat protein (G-beta like protein) involved in translationregulation; required for repression of Gcn4pactivity in the absence of amino-acidstarvation; core component of the ribosome;ortholog of mammalian RACK1 0.047710.48101&radic&radic S000000288MIS1YBR084WverifiedMitochondrial C1-tetrahydrofolate synthase, involved ininterconversion between different oxidationstates of tetrahydrofolate (THF); providesactivities of formyl-THF synthetase,methenyl-THF cyclohydrolase, and methylene-THFdehydrogenase 0.042410.45633&radic S000001065MYO1YHR023WverifiedType II myosin heavy chain, required for wild-type cytokinesisand cell separation; localizes to theactomyosin ring; binds to myosin light chainsMlc1p and Mlc2p through its IQ1 and IQ2 motifsrespectively 0.037870.4313&radic S000003322UTP22YGR090WuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.034220.41073&radic&radic&radic S000002793EFT2YDR385WverifiedElongation factor 2 (EF-2), also encoded by EFT1; catalyzesribosomal translocation during proteinsynthesis; contains diphthamide, the uniqueposttranslationally modified histidine residuespecifically ADP-ribosylated by diphtheriatoxin 0.030850.39251&radic&radic&radic&radic S000005335POP2YNR052CverifiedRNase of the DEDD superfamily, subunit of the Ccr4-Not complexthat mediates 3' to 5' mRNA deadenylation 0.029980.38713&radic&radic&radic&radic S000005922HAT1YPL001WverifiedCatalytic subunit of the Hat1p-Hat2p histone acetyltransferasecomplex that uses the cofactor acetyl coenzymeA, to acetylate free nuclear and cytoplasmichistone H4; involved in telomeric silencing andDNA double-strand break repair 0.027720.37364 S000004754TIF34YMR146CverifiedSubunit of the core complex of translation initiation factor3(eIF3), which is essential for translation 0.02750.37171&radic&radic S000004198SEC13YLR208WverifiedComponent of both the Nup84 nuclear pore sub-complex and of theCOPII complex (Sar1p, Sec13p, Sec16p, Sec23p,Sec24p, Sec31p, Sfb2p, and Sfb3p) which isimportant for the formation of ER to Golgitransport vesicles 0.027480.37171&radic&radic S000003712SWI3YJL176CverifiedSubunit of the SWI/SNF chromatin remodeling complex, whichregulates transcription by remodelingchromosomes; required for transcription of manygenes, including ADH1, ADH2, GAL1, HO, INO1 andSUC2 0.026230.36198&radic&radic S000004599ERO1YML130CverifiedThiol oxidase required for oxidative protein folding in theendoplasmic reticulum 0.025570.3588&radic S000005606DIA2YOR080WverifiedOrigin-binding F-box protein that forms an SCF ubiquitin ligasecomplex with Skp1p and Cdc53p; plays a role inDNA replication, involved in invasive andpseudohyphal growth 0.023610.34336&radic&radic S000003858JJJ3YJR097WverifiedProtein of unknown function, contains a J-domain, which is aregion with homology to the E. coli DnaJprotein &radic0.022530.33388&radic&radic S000003068SEH1YGL100WverifiedNuclear pore protein that is part of the evolutionarilyconserved Nup84p complex (Nup84p, Nup85p,Nup120p, Nup145p, and Seh1p); homologous toSec13p 0.021510.32417&radic S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling 0.020980.31997&radic&radic&radic S000004376IKI3YLR384CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;maintains structural integrity of Elongator;homolog of human IKAP, mutations in which causefamilial dysautonomia (FD) 0.019210.30065&radic S000004559GIM5YML094WverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.019170.30045&radic&radic&radic S000001221STB5YHR178WverifiedActivator of multidrug resistance genes, forms a heterodimerwith Pdr1p; contains a Zn(II)2Cys6 zinc fingerdomain that interacts with a PDRE (pleotropicdrug resistance element) in vitro; binds Sin3pin a two-hybrid assay 0.017980.28548&radic&radic&radic&radic&radic S000004409VPS36YLR417WverifiedComponent of the ESCRT-II complex; contains the GLUE (GRAM LikeUbiquitin binding in EAP45) domain which isinvolved in interactions with ESCRT-I andubiquitin-dependent sorting of proteins intothe endosome 0.017970.28495&radic&radic&radic&radic&radic S000000602RVS161YCR009CverifiedAmphiphysin-like lipid raft protein; subunit of a complex(Rvs161p-Rvs167p) that regulates polarizationof the actin cytoskeleton, endocytosis, cellpolarity, cell fusion and viability followingstarvation or osmotic stress 0.017280.2758&radic&radic&radic S000000018ATS1YAL020CverifiedProtein required, with Elongator complex, Kti11p, and Kti12p,for modification of wobble nucleosides in tRNA;has a potential role in regulatory interactionsbetween microtubules and the cell cycle 0.01670.26868&radic&radic S000005735NPT1YOR209CverifiedNicotinate phosphoribosyltransferase, acts in the salvagepathway of NAD+ biosynthesis; required forsilencing at rDNA and telomeres and has a rolein silencing at mating-type loci; localized tothe nucleus 0.016690.26868&radic&radic S000000379SWD3YBR175WverifiedEssential subunit of the COMPASS (Set1C) complex, whichmethylates histone H3 on lysine 4 and isrequired in transcriptional silencing neartelomeres; WD40 beta propeller superfamilymember and ortholog of mammalian WDR5 0.014890.24286&radic&radic S000005364SIN3YOL004WverifiedComponent of the Sin3p-Rpd3p histone deacetylase complex,involved in transcriptional repression andactivation of diverse processes, includingmating-type switching and meiosis; involved inthe maintenance of chromosomal integrity 0.014590.23918&radic&radic S000003194OST5YGL226C-AverifiedZeta subunit of the oligosaccharyltransferase complex of the ERlumen, which catalyzes asparagine-linkedglycosylation of newly synthesized proteins 0.014440.23724 S000001777MET1YKR069WverifiedS-adenosyl-L-methionine uroporphyrinogen III transmethylase,involved in sulfate assimilation, methioninemetabolism, and siroheme biosynthesis 0.013760.22764&radic&radic S000000792HPA3YEL066WverifiedD-Amino acid N-acetyltransferase, catalyzes N-acetylation ofD-amino acids through ordered bi-bi mechanismin which acetyl-CoA is first substrate boundand CoA is last product liberated; similar toHpa2p, acetylates histones weakly in vitro 0.013710.22685&radic S000002840NPL3YDR432WverifiedRNA-binding protein that carries poly(A)+ mRNA from the nucleusinto the cytoplasm; phosphorylation by Sky1p inthe cytoplasm may promote release of mRNAs 0.013610.22562&radic S000006397HPA2YPR193CverifiedTetrameric histone acetyltransferase with similarity to Gcn5p,Hat1p, Elp3p, and Hpa3p; acetylates histones H3and H4 in vitro and exhibits autoacetylationactivity 0.013580.22519&radic S000001871BUD27YFL023WverifiedProtein involved in bud-site selection, nutrient signaling, andgene expression controlled by the TOR kinase;diploid mutants display a random buddingpattern instead of the wild-type bipolarpattern 0.013580.22519&radic&radic&radic&radic S000003463PHB2YGR231CverifiedSubunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDaring-shaped inner mitochondrial membranechaperone that stabilizes newly synthesizedproteins; determinant of replicative life span;involved in mitochondrial segregation 0.013420.2224&radic&radic S000004279MEC3YLR288CverifiedDNA damage and meiotic pachytene checkpoint protein; subunit ofa heterotrimeric complex (Rad17p-Mec3p-Ddc1p)that forms a sliding clamp, loaded onto partialduplex DNA by a clamp loader complex; homologof human and S. pombe Hus1 0.013340.22114&radic S000001068PPA1YHR026WverifiedSubunit c'' of the vacuolar ATPase, which functions inacidification of the vacuole; one of threeproteolipid subunits of the V0 domain 0.013220.21861 S000003956IRC19YLL033WuncharacterizedPutative protein of unknown function; YLL033W is not anessential gene but mutant is defective in sporeformation; null mutant displays increasedlevels of spontaneous Rad52 foci 0.013180.21833&radic S000000885GET2YER083CverifiedSubunit of the GET complex; required for meiotic nucleardivision and for the retrieval of HDEL proteinsfrom the Golgi to the ER in an ERD2 dependentfashion; may be involved in cell wall function 0.01310.21717&radic&radic S000001877GNA1YFL017CverifiedEvolutionarily conserved glucosamine-6-phosphateacetyltransferase required for multiple cellcycle events including passage through START,DNA synthesis, and mitosis; involved inUDP-N-acetylglucosamine synthesis, formsGlcNAc6P from AcCoA 0.012990.21575&radic S000002903VPS3YDR495CverifiedCytoplasmic protein required for the sorting and processing ofsoluble vacuolar proteins, acidification of thevacuolar lumen, and assembly of the vacuolarH+-ATPase 0.012940.21396&radic&radic S000002796RVS167YDR388WverifiedActin-associated protein, subunit of a complex(Rvs161p-Rvs167p) involved in regulation ofactin cytoskeleton, endocytosis, and viabilityfollowing starvation or osmotic stress; homologof mammalian amphiphysin 0.012840.21338&radic&radic S000002478PAA1YDR071CverifiedPolyamine acetyltransferase; acetylates polyamines (e.g.putrescine, spermidine, spermine) and alsoaralkylamines (e.g. tryptamine,phenylethylamine); may be involved intranscription and/or DNA replication 0.012490.20826&radic S000002877SDC1YDR469WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres; hassimilarity to C. elegans Dpy-30 0.012290.2056 S000005561SHE4YOR035CverifiedProtein containing a UCS (UNC-45/CRO1/SHE4) domain, binds tomyosin motor domains to regulate myosinfunction; involved in endocytosis, polarizationof the actin cytoskeleton, and asymmetric mRNAlocalization 0.012260.20478&radic&radic&radic&radic S000002731PEP7YDR323CverifiedMultivalent adaptor protein that facilitates vesicle-mediatedvacuolar protein sorting by ensuringhigh-fidelity vesicle docking and fusion, whichare essential for targeting of vesicles to theendosome; required for vacuole inheritance 0.012150.20359 S000005436MDM20YOL076WverifiedNon-catalytic subunit of the NatB N-terminal acetyltransferase,which catalyzes acetylation of theamino-terminal methionine residues of allproteins beginning with Met-Asp or Met-Glu andof some proteins beginning with Met-Asn orMet-Met; involved in mitochondrial inheritanceand actin assembly &radic0.012160.20359&radic&radic&radic&radic&radic S000004673NAT4YMR069WverifiedN alpha-acetyl-transferase, involved in acetylation of theN-terminal residues of histones H4 and H2A 0.012150.20355&radic S000003432ELP2YGR200CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;target of Kluyveromyces lactis zymocin 0.01210.20283&radic&radic&radic&radic S000002391OST4YDL232WverifiedSubunit of the oligosaccharyltransferase complex of the ERlumen, which catalyzes proteinasparagine-linked glycosylation; type Imembrane protein required for incorporation ofOst3p or Ost6p into the OST complex 0.012080.20247 S000005505CTR9YOL145CverifiedComponent of the Paf1p complex, which is a large complex thatbinds to and modulates the activity of RNApolymerase II and is required for expression ofa subset of genes, including cyclin genes;contains TPR repeats 0.012030.20151 S000004798HSC82YMR186WverifiedCytoplasmic chaperone of the Hsp90 family, redundant infunction and nearly identical with Hsp82p, andtogether they are essential; expressedconstitutively at 10-fold higher basal levelsthat HSP82 and induced 2-3 fold by heat shock 0.01190.20016&radic S000002848DOT1YDR440WverifiedNucleosomal histone H3-Lys79 methylase, associates withtranscriptionally active genes, functions ingene silencing at telomeres, most likely bydirectly modulating chromatin structure and Sirprotein localization 0.011860.1996&radic S000005629OST2YOR103CverifiedEpsilon subunit of the oligosaccharyltransferase complex of theER lumen, which catalyzes asparagine-linkedglycosylation of newly synthesized proteins 0.011610.19621&radic S000001481YIR042CUncharacterizedPutative protein of unknown function; YIR042C is a non-essential gene 0.01160.19621 S000001695SAC1YKL212WverifiedLipid phosphoinositide phosphatase of the ER and Golgi,involved in protein trafficking and secretion 0.011610.19621&radic&radic&radic&radic S000001906UBP6YFR010WverifiedUbiquitin-specific protease situated in the base subcomplex ofthe 26S proteasome, releases free ubiquitinfrom branched polyubiquitin chains; deletioncauses hypersensitivity to cycloheximide andother toxic compounds 0.011560.19613&radic&radic&radic&radic S000003539OST1YJL002CverifiedAlpha subunit of the oligosaccharyltransferase complex of theER lumen, which catalyzes asparagine-linkedglycosylation of newly synthesized proteins &radic0.011410.19381&radic S000002164PTC1YDL006WverifiedType 2C protein phosphatase (PP2C); inactivates the osmosensingMAPK cascade by dephosphorylating Hog1p;mutation delays mitochondrial inheritance;deletion reveals defects in precursor tRNAsplicing, sporulation and cell separation 0.011410.19377&radic&radic&radic S000004563VPS9YML097CverifiedA guanine nucleotide exchange factor involved invesicle-mediated vacuolar protein transport;specifically stimulates the intrinsic guaninenucleotide exchange activity of Vps21p/Rab5:similar to mammalian ras inhibitors; bindsubiquitin 0.011260.19124&radic&radic S000003863VPS25YJR102CverifiedComponent of the ESCRT-II complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome 0.011240.19124&radic&radic&radic S000003663SPT10YJL127CverifiedPutative histone acetylase, sequence-specific activator ofhistone genes, binds specifically and highlycooperatively to pairs of UAS elements in corehistone promoters, functions at or near theTATA box 0.011190.19039&radic S000006339CTF4YPR135WverifiedChromatin-associated protein, required for sister chromatidcohesion; interacts with DNA polymerase alpha(Pol1p) and may link DNA synthesis to sisterchromatid cohesion 0.011120.18923&radic&radic S000000064SWD1YAR003WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres; WD40beta propeller superfamily member withsimilarity to mammalian Rbbp7 0.011060.18908&radic&radic S000000682CSM1YCR086WverifiedNucleolar protein that forms a complex with Lrs4p which bindsMam1p at kinetochores during meiosis I tomediate accurate chromosome segregation, may beinvolved in premeiotic DNA replication;possible role in telomere maintenance 0.011020.18877&radic S000003310PAC10YGR078CverifiedPart of the heteromeric co-chaperone GimC/prefoldin complex,which promotes efficient protein folding 0.010890.18667&radic&radic&radic&radic S000004069SIC1YLR079WverifiedInhibitor of Cdc28-Clb kinase complexes that controls G1/Sphase transition, preventing premature S phaseand ensuring genomic integrity; phosphorylationtargets Sic1p for SCF(CDC4)-dependent turnover;functional homolog of mammalian Kip1 0.010790.18532&radic S000003484GCN5YGR252WverifiedHistone acetyltransferase, acetylates N-terminal lysines onhistones H2B and H3; catalytic subunit of theADA and SAGA histone acetyltransferasecomplexes; founding member of the Gcn5p-relatedN-acetyltransferase superfamily 0.010720.1844 S000001072SLT2YHR030CverifiedSerine/threonine MAP kinase involved in regulating themaintenance of cell wall integrity andprogression through the cell cycle; regulatedby the PKC1-mediated signaling pathway 0.010650.18356&radic&radic&radic S000005643RPT5YOR117WverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; recruited to theGAL1-10 promoter region upon induction oftranscription 0.01060.1827&radic S000002767VID21YDR359CverifiedComponent of the NuA4 histone acetyltransferase complex 0.010550.18214&radic&radic&radic S000004481OST6YML019WverifiedSubunit of the oligosaccharyltransferase complex of the ERlumen, which catalyzes asparagine-linkedglycosylation of newly synthesized proteins;similar to and partially functionally redundantwith Ost3p &radic0.01050.18171&radic&radic&radic&radic S000002178RPN4YDL020CverifiedTranscription factor that stimulates expression of proteasomegenes; Rpn4p levels are in turn regulated bythe 26S proteasome in a negative feedbackcontrol mechanism; RPN4 is transcriptionallyregulated by various stress responses 0.01030.17863&radic&radic&radic S000001337RPN2YIL075CverifiedSubunit of the 26S proteasome, substrate of theN-acetyltransferase Nat1p 0.010150.17625&radic S000004410CDC73YLR418CverifiedConstituent of Paf1 complex with RNA polymerase II, Paf1p,Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinctfrom Srb-containing Pol II complexes; requiredfor expression of certain genes, modificationof some histones, and telomere maintenance 0.01010.17577&radic&radic&radic&radic&radic S000000019CCR4YAL021CverifiedComponent of the CCR4-NOT transcriptional complex, which isinvolved in regulation of gene expression;component of the major cytoplasmic deadenylase,which is involved in mRNA poly(A) tailshortening 0.009950.17372&radic&radic S000004005BRE2YLR015WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres;involved in telomere maintenance; similar totrithorax-group protein ASH2L 0.009820.17193&radic S000002562CPR1YDR155CverifiedCytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin),catalyzes the cis-trans isomerization ofpeptide bonds N-terminal to proline residues;binds the drug cyclosporin A 0.009680.16938&radic S000000201PKC1YBL105CverifiedProtein serine/threonine kinase essential for cell wallremodeling during growth; localized to sites ofpolarized growth and the mother-daughter budneck; homolog of the alpha, beta, and gammaisoforms of mammalian protein kinase C (PKC) 0.009680.16938&radic S000002299RPO21YDL140CverifiedRNA polymerase II largest subunit B220, part of central core;phosphorylation of C-terminal heptapeptiderepeat domain regulates association withtranscription and splicing factors; similar tobacterial beta-prime 0.009530.16675 S000006305SNT309YPR101WverifiedComponent of NineTeen complex (NTC) containing Prp19p involvedin mRNA splicing, interacts physically andgenetically with Prp19p 0.009440.16557 S000003660LSM1YJL124CverifiedLsm (Like Sm) protein; forms heteroheptameric complex (withLsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p)involved in degradation of cytoplasmic mRNAs 0.00940.16519&radic&radic&radic S000005023TPM1YNL079CverifiedMajor isoform of tropomyosin; binds to and stabilizes actincables and filaments, which direct polarizedcell growth and the distribution of severalorganelles; acetylated by the NatB complex andacetylated form binds actin most efficiently 0.009380.16482 S000004580CTK3YML112WverifiedGamma subunit of C-terminal domain kinase I (CTDK-I), whichphosphorylates the C-terminal repeated domainof the RNA polymerase II large subunit (Rpo21p)to affect both transcription and pre-mRNA 3'end processing 0.009270.1624&radic&radic&radic S000005289VPS27YNR006WverifiedEndosomal protein that forms a complex with Hse1p; required forrecycling Golgi proteins, forming lumenalmembranes and sorting ubiquitinated proteinsdestined for degradation; has UbiquitinInteraction Motifs which bind ubiquitin (Ubi4p) 0.009320.1624&radic&radic&radic S000003631BCK1YJL095WverifiedMitogen-activated protein (MAP) kinase kinase kinase acting inthe protein kinase C signaling pathway, whichcontrols cell integrity; upon activation byPkc1p phosphorylates downstream kinases Mkk1pand Mkk2p 0.009130.15996&radic&radic&radic S000002255RPN6YDL097CverifiedEssential, non-ATPase regulatory subunit of the 26S proteasomelid required for the assembly and activity ofthe 26S proteasome; the human homolog (S9protein) partially rescues Rpn6p depletion 0.009080.15915&radic S000001210THP2YHR167WverifiedSubunit of the THO complex, which connects transcriptionelongation and mitotic recombination, and ofthe TREX complex, which is recruited toactivated genes and couples transcription tomRNA export; involved in telomere maintenance 0.009080.15915&radic&radic&radic S000003420BUB1YGR188CverifiedProtein kinase that forms a complex with Mad1p and Bub3p thatis crucial in the checkpoint mechanism requiredto prevent cell cycle progression into anaphasein the presence of spindle damage, associateswith centromere DNA via Skp1p 0.008940.15684&radic&radic S000005923SNF8YPL002CverifiedComponent of the ESCRT-II complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; appears to be functionallyrelated to SNF7; involved in glucosederepression 0.008870.15583&radic&radic&radic S000004329VRP1YLR337CverifiedProline-rich actin-associated protein involved in cytoskeletalorganization and cytokinesis; related tomammalian Wiskott-Aldrich syndrome protein(WASP)-interacting protein (WIP) 0.008860.15533&radic&radic&radic S000003924DNM1YLL001WverifiedDynamin-related GTPase required for mitochondrial fission andthe maintenance of mitochondrial morphology,assembles on the cytoplasmic face ofmitochondrial tubules at sites at whichdivision will occur; also participates inendocytosis 0.008640.15245&radic S000005481RPS19AYOL121CverifiedProtein component of the small (40S) ribosomal subunit,required for assembly and maturation of pre-40S particles; mutations in human RPS19 areassociated with Diamond Blackfan anemia; nearlyidentical to Rps19Bp 0.008620.15189&radic S000000957BEM2YER155CverifiedRho GTPase activating protein (RhoGAP) involved in the controlof cytoskeleton organization and cellularmorphogenesis; required for bud emergence 0.008610.15189&radic&radic S000006324CLB5YPR120CverifiedB-type cyclin involved in DNA replication during S phase;activates Cdc28p to promote initiation of DNAsynthesis; functions in formation of mitoticspindles along with Clb3p and Clb4p; mostabundant during late G1 phase 0.00860.15167&radic&radic S000005859VMA4YOR332WverifiedSubunit E of the eight-subunit V1 peripheral membrane domain ofthe vacuolar H+-ATPase (V-ATPase), anelectrogenic proton pump found throughout theendomembrane system; required for the V1 domainto assemble onto the vacuolar membrane 0.008530.15087&radic&radic&radic S000000340MEC1YBR136WverifiedGenome integrity checkpoint protein and PI kinase superfamilymember; signal transducer required for cellcycle arrest and transcriptional responsesprompted by damaged or unreplicated DNA;monitors and participates in meioticrecombination 0.008330.14786 S000000435SWC5YBR231CuncharacterizedProtein of unknown function, component of the SWR1 complex,which exchanges histone variant H2AZ (Htz1p)for chromatin-bound histone H2A 0.008340.14786&radic&radic S000003026RAD6YGL058WverifiedUbiquitin-conjugating enzyme (E2), involved in postreplicationrepair (with Rad18p), sporulation, telomeresilencing, and ubiquitin-mediated N-end ruleprotein degradation (with Ubr1p) 0.00820.14595&radic&radic S000004370SEC61YLR378CverifiedEssential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p);forms a channel for SRP-dependent proteinimport and retrograde transport of misfoldedproteins out of the ER; with Sec63 complexallows SRP-independent protein import into ER 0.007980.14279&radic S000001855ACT1YFL039CverifiedActin, structural protein involved in cell polarization,endocytosis, and other cytoskeletal functions 0.007990.14279 S000000514STP22YCL008CverifiedComponent of the ESCRT-I complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; homologous to the mouse and humanTsg101 tumor susceptibility gene; mutantsexhibit a Class E Vps phenotype 0.007970.14245&radic&radic&radic S000000760HYP2YEL034WverifiedTranslation initiation factor eIF-5A, promotes formation of thefirst peptide bond; similar to and functionallyredundant with Anb1p; possible role intranslation elongation; undergoes an essentialhypusination modification 0.007880.14113 S000002786LSM6YDR378CverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.007890.14113&radic&radic S000002200SIR2YDL042CverifiedConserved NAD+ dependent histone deacetylase of the Sirtuinfamily involved in regulation of lifespan;plays roles in silencing at HML, HMR,telomeres, and the rDNA locus; negativelyregulates initiation of DNA replication 0.007870.14074 S000006005BRO1YPL084WverifiedCytoplasmic class E vacuolar protein sorting (VPS) factor thatcoordinates deubiquitination in themultivesicular body (MVB) pathway by recruitingDoa4p to endosomes 0.00770.13817&radic&radic&radic&radic S000002127SBH2YER019C-AverifiedSsh1p-Sss1p-Sbh2p complex component, involved in proteintranslocation into the endoplasmic reticulum;homologous to Sbh1p 0.007720.13817&radic S000003440SER2YGR208WverifiedPhosphoserine phosphatase of the phosphoglycerate pathway,involved in serine and glycine biosynthesis,expression is regulated by the availablenitrogen source 0.007650.13726&radic&radic S000004075ARP6YLR085CverifiedActin-related protein that binds nucleosomes; a component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.007590.13622&radic&radic&radic S000003632MRPL49YJL096WverifiedMitochondrial ribosomal protein of the large subunit 0.007470.1343 S000005895RAD17YOR368WverifiedCheckpoint protein, involved in the activation of the DNAdamage and meiotic pachytene checkpoints; withMec3p and Ddc1p, forms a clamp that is loadedonto partial duplex DNA; homolog of human andS. pombe Rad1 and U. maydis Rec1 proteins 0.007460.13397&radic&radic S000001469DCG1YIR030CverifiedProtein of unknown function, expression is sensitive tonitrogen catabolite repression and regulated byDal80p; contains transmembrane domain 0.00740.1332 S000005051YAF9YNL107WverifiedSubunit of both the NuA4 histone H4 acetyltransferase complexand the SWR1 complex, may function toantagonize silencing near telomeres; interactsdirectly with Swc4p, has homology to humanleukemogenic protein AF9, contains a YEATSdomain 0.007410.1332&radic&radic&radic S000005097GIM3YNL153CverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.007240.12997&radic&radic S000004172SWI6YLR182WverifiedTranscription cofactor, forms complexes with DNA-bindingproteins Swi4p and Mbp1p to regulatetranscription at the G1/S transition; involvedin meiotic gene expression; localizationregulated by phosphorylation; potential Cdc28psubstrate 0.007230.12997&radic S000005622RPS7AYOR096WverifiedProtein component of the small (40S) ribosomal subunit, nearlyidentical to Rps7Bp; interacts with Kti11p;deletion causes hypersensitivity to zymocin;has similarity to rat S7 and Xenopus S8ribosomal proteins 0.007210.1293 S000001809SIR1YKR101WverifiedProtein involved in repression of transcription at the silentmating-type loci HML and HMR; recruitment tosilent chromatin requires interactions withOrc1p and with Sir4p, through a common Sir1pdomain; binds to centromeric chromatin 0.007210.1293 S000002652PEX5YDR244WverifiedPeroxisomal membrane signal receptor for C-terminal tripeptidesignal sequence (PTS1) of peroxisomal matrixproteins, required for peroxisomal matrixprotein import, tetratricopeptide repeatprotein, also involved in PTS1-independentimport 0.007190.1293 S000001915FAB1YFR019Wverified1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membranekinase that generates phosphatidylinositol(3,5)P2, which is involved in vacuolar sortingand homeostasis 0.007180.12906&radic S000004523SML1YML058WverifiedRibonucleotide reductase inhibitor involved in regulating dNTPproduction; regulated by Mec1p and Rad53pduring DNA damage and S phase 0.007170.12906&radic S000002943YDR535CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene. 0.007170.12906&radic S000005593ALG8YOR067CverifiedGlucosyl transferase, involved in N-linked glycosylation; addsglucose to the dolichol-linked oligosaccharideprecursor prior to transfer to protein duringlipid-linked oligosaccharide biosynthesis;similar to Alg6p 0.007120.12841&radic&radic&radic S000006059SPP1YPL138CverifiedSubunit of COMPASS (Set1C), a complex which methylates histoneH3 on lysine 4 and is required in telomerictranscriptional silencing; PHD finger domainprotein similar to human CGBP, an unmethylatedCpG binding protein 0.007070.12717&radic&radic S000000689CDC39YCR093WverifiedComponent of the CCR4-NOT complex, which has multiple roles inregulating mRNA levels including regulation oftranscription and destabilizing mRNAs bydeadenylation; basal transcription factor 0.007020.12655&radic&radic S000003827TOR1YJR066WverifiedPIK-related protein kinase and rapamycin target; subunit ofTORC1, a complex that controls growth inresponse to nutrients by regulatingtranslation, transcription, ribosomebiogenesis, nutrient transport and autophagy;involved in meiosis 0.007010.12648&radic&radic&radic S000004827SCJ1YMR214WverifiedOne of several homologs of bacterial chaperone DnaJ, located inthe ER lumen where it cooperates with Kar2p tomediate maturation of proteins 0.0070.12631&radic&radic S000001341AIR1YIL079CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p to regulate methylationof Npl3p, which modulates Npl3p function inmRNA processing and export; has similarity toAir2p 0.006890.1244&radic S000004252YPT6YLR262CverifiedGTPase, Ras-like GTP binding protein involved in the secretorypathway, required for fusion ofendosome-derived vesicles with the late Golgi,maturation of the vacuolar carboxypeptidase Y;has similarity to the human GTPase, Rab6 0.006880.1243&radic&radic&radic S000000918SLX8YER116CverifiedProtein containing a RING finger domain that interacts withHex3p; mutant phenotypes and geneticinteractions suggest a role in sumoylation andin genome stability 0.006830.12326&radic&radic S000002259DUN1YDL101CverifiedCell-cycle checkpoint serine-threonine kinase required for DNAdamage-induced transcription of certain targetgenes, phosphorylation of Rad55p and Sml1p, andtransient G2/M arrest after DNA damage; alsoregulates postreplicative DNA repair 0.006720.12179 S000000007SPO7YAL009WverifiedIntegral nuclear/ER membrane protein of unknown function,required for normal nuclear envelope morphologyand sporulation 0.00670.12141&radic S000001665FAS1YKL182WverifiedBeta subunit of fatty acid synthetase, which catalyzes thesynthesis of long-chain saturated fatty acids;contains acetyltransacylase, dehydratase, enoylreductase, malonyl transacylase, and palmitoyltransacylase activities 0.006590.1195&radic&radic S000004887RCE1YMR274CverifiedType II CAAX prenyl protease involved in the proteolysis andmaturation of Ras and the a-factor matingpheromone 0.006550.11868&radic&radic S000005849LDB19YOR322CverifiedProtein of unknown function involved in maintenance of propertelomere length; null mutant shows a reducedaffinity for the alcian blue dye suggesting adecreased net negative charge of the cellsurface 0.006530.1185&radic&radic&radic&radic S000004190YKE2YLR200WverifiedSubunit of the heterohexameric Gim/prefoldin protein complexinvolved in the folding of alpha-tubulin,beta-tubulin, and actin 0.006510.11824&radic&radic S000002388SSB1YDL229WverifiedCytoplasmic ATPase that is a ribosome-associated molecularchaperone, functions with J-protein partnerZuo1p; may be involved in folding of newly-madepolypeptide chains; member of the HSP70 family;interacts with phosphatase subunit Reg1p 0.006490.11802&radic S000001400TPM2YIL138CverifiedMinor isoform of tropomyosin, binds to and stabilizes actincables and filaments, which direct polarizedcell growth and the distribution of severalorganelles; appears to have distinct and alsooverlapping functions with Tpm1p 0.006450.11711&radic S000005468INO4YOL108CverifiedTranscription factor required for derepression ofinositol-choline-regulated genes involved inphospholipid synthesis; forms a complex, withIno2p, that binds theinositol-choline-responsive element through abasic helix-loop-helix domain 0.006480.11711&radic S000005976LGE1YPL055CverifiedProtein of unknown function; null mutant forms abnormally largecells 0.006420.11645&radic S000004029RIC1YLR039CverifiedProtein involved in retrograde transport to the cis-Golginetwork; forms heterodimer with Rgp1p that actsas a GTP exchange factor for Ypt6p; involved intranscription of rRNA and ribosomal proteingenes 0.006430.11645&radic S000003141KEM1YGL173CverifiedEvolutionarily-conserved 5'-3' exonuclease component ofcytoplasmic processing (P) bodies involved inmRNA decay; plays a role inmicrotubule-mediated processes, filamentousgrowth, ribosomal RNA maturation, and telomeremaintenance 0.006390.11583&radic S000004683CTF18YMR078CverifiedSubunit of a complex with Ctf8p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion; may have overlappingfunctions with Rad24p in the DNA damagereplication checkpoint 0.006370.11548&radic S000001895DEG1YFL001WverifiedNon-essential tRNA:pseudouridine synthase, introducespseudouridines at position 38 or 39 in tRNA,important for maintenance of translationefficiency and normal cell growth, localizes toboth the nucleus and cytoplasm 0.006370.11548&radic&radic S000003412RNR4YGR180CverifiedRibonucleotide-diphosphate reductase (RNR), small subunit; theRNR complex catalyzes the rate-limiting step indNTP synthesis and is regulated by DNAreplication and DNA damage checkpoint pathwaysvia localization of the small subunits 0.006320.11452&radic&radic S000003598LAS21YJL062WverifiedIntegral plasma membrane protein involved in the synthesis ofthe glycosylphosphatidylinositol (GPI) corestructure; mutations affect cell wall integrity 0.006230.11326&radic S000003567MAD2YJL030WverifiedComponent of the spindle-assembly checkpoint complex, whichdelays the onset of anaphase in cells withdefects in mitotic spindle assembly; forms acomplex with Mad1p 0.00610.11083&radic S000000975RAD24YER173WverifiedCheckpoint protein, involved in the activation of the DNAdamage and meiotic pachytene checkpoints;subunit of a clamp loader that loadsRad17p-Mec3p-Ddc1p onto DNA; homolog of humanand S. pombe Rad17 protein 0.006080.10991&radic S000004334FKS1YLR342WverifiedCatalytic subunit of 1,3-beta-D-glucan synthase, functionallyredundant with alternate catalytic subunitGsc2p; binds to regulatory subunit Rho1p;involved in cell wall synthesis andmaintenance; localizes to sites of cell wallremodeling 0.005950.10821&radic S000004682VPS20YMR077CverifiedMyristoylated subunit of ESCRTIII, the endosomal sortingcomplex required for transport of transmembraneproteins into the multivesicular body pathwayto the lysosomal/vacuolar lumen; cytoplasmicprotein recruited to endosomal membranes 0.005870.10617&radic&radic S000006257YPR053CDubiousHypothetical protein 0.005860.10617 S000003063VPS45YGL095CverifiedProtein of the Sec1p/Munc-18 family, essential for vacuolarprotein sorting; required for the function ofPep12p and the early endosome/late Golgi SNARETlg2p; essential for fusion of Golgi-derivedvesicles with the prevacuolar compartment 0.005820.10495&radic&radic S000004494RAD52YML032CverifiedProtein that stimulates strand exchange by facilitating Rad51pbinding to single-stranded DNA; annealscomplementary single-stranded DNA; involved inthe repair of double-strand breaks in DNAduring vegetative growth and meiosis 0.005780.10438 S000002172NOP1YDL014WverifiedNucleolar protein, component of the small subunit processomecomplex, which is required for processing ofpre-18S rRNA; has similarity to mammalianfibrillarin 0.005740.10367 S000004610PLB1YMR008CverifiedPhospholipase B (lysophospholipase) involved in lipidmetabolism, required for deacylation ofphosphatidylcholine andphosphatidylethanolamine but notphosphatidylinositol 0.005690.10271 S000000776RML2YEL050CverifiedMitochondrial ribosomal protein of the large subunit, hassimilarity to E. coli L2 ribosomal protein;fat21 mutant allele causes inability to utilizeoleate and may interfere with activity of theAdr1p transcription factor 0.005660.10188&radic S000005503RIB4YOL143CverifiedLumazine synthase (6,7-dimethyl-8-ribityllumazine synthase,also known as DMRL synthase); catalyzessynthesis of immediate precursor to riboflavin 0.00560.1005&radic S000005194RAD50YNL250WverifiedSubunit of MRX complex, with Mre11p and Xrs2p, involved inprocessing double-strand DNA breaks invegetative cells, initiation of meiotic DSBs,telomere maintenance, and nonhomologous endjoining 0.005620.1005&radic S000000818BIM1YER016WverifiedMicrotubule-binding protein that together with Kar9p makes upthe cortical microtubule capture site anddelays the exit from mitosis when the spindleis oriented abnormally 0.005590.1005 S000003836HOC1YJR075WverifiedAlpha-1,6-mannosyltransferase involved in cell wall mannanbiosynthesis; subunit of a Golgi-localizedcomplex that also contains Anp1p, Mnn9p,Mnn11p, and Mnn10p; identified as a suppressorof a cell lysis sensitive pkc1-371 allele 0.00560.1005&radic S000001933RSC8YFR037CverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; essential for viability andmitotic growth; homolog of SWI/SNF subunitSwi3p, but unlike Swi3p, does not activatetranscription of reporters 0.005610.1005&radic S000001234CTF8YHR191CverifiedSubunit of a complex with Ctf18p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion 0.005570.10015 S000001596RAD27YKL113Cverified5' to 3' exonuclease, 5' flap endonuclease, required forOkazaki fragment processing and maturation aswell as for long-patch base-excision repair;member of the S. pombe RAD2/FEN1 family 0.005560.10015 S000000794YEL068CDubiousHypothetical protein 0.005540.09956&radic S000002988GET1YGL020CverifiedSubunit of the GET complex; required for the retrieval of HDELproteins from the Golgi to the ER in an ERD2dependent fashion and for normal mitochondrialmorphology and inheritance 0.005520.09911 S000005217TOF1YNL273WverifiedSubunit of a replication-pausing checkpoint complex(Tof1p-Mrc1p-Csm3p) that acts at the stalledreplication fork to promote sister chromatidcohesion after DNA damage, facilitating gaprepair of damaged DNA; interacts with the MCMhelicase 0.00550.09866&radic&radic S000000297PHO5YBR093CverifiedRepressible acid phosphatase (1 of 3) that also mediatesextracellular nucleotide-derived phosphatehydrolysis; secretory pathway derived cellsurface glycoprotein; induced by phosphatestarvation and coordinately regulated by PHO4and PHO2 0.005490.09838 S000004761YMR153C-ADubiousHypothetical protein 0.005490.09838&radic S000001046NEM1YHR004CverifiedProtein of the nuclear envelope required for the sphericalshape of the nucleus; required for normalsporulation 0.005480.09838&radic S000002607YDR199WDubiousHypothetical protein 0.005490.09838&radic S000004530ORC1YML065WverifiedLargest subunit of the origin recognition complex, whichdirects DNA replication by binding toreplication origins and is also involved intranscriptional silencing; may bephosphorylated by Cdc28p 0.005450.0975 S000004973YNL028WDubiousHypothetical protein 0.005420.09675&radic S000004365VID22YLR373CverifiedGlycosylated integral membrane protein localized to the plasmamembrane; plays a role infructose-1,6-bisphosphatase (FBPase)degradation; involved in FBPase transport fromthe cytosol to Vid (vacuole import anddegradation) vesicles 0.005410.09675&radic&radic S000002254OPI6YDL096CdubiousDubious open reading frame unlikely to encode a protein, basedon available experimental and comparativesequence data; partially overlaps verified genePMT1/YDL095W; YDL096C is not essential 0.005420.09675&radic S000000913SWI4YER111CverifiedDNA binding component of the SBF complex (Swi4p-Swi6p), atranscriptional activator that in concert withMBF (Mbp1-Swi6p) regulates late G1-specifictranscription of targets including cyclins andgenes required for DNA synthesis and repair 0.00540.09618&radic S000004434SIR3YLR442CverifiedSilencing protein that interacts with Sir2p and Sir4p, andhistone H3 and H4 tails, to establish atranscriptionally silent chromatin state;required for spreading of silenced chromatin;recruited to chromatin through interaction withRap1p 0.005380.09618 S000005659EFT1YOR133WverifiedElongation factor 2 (EF-2), also encoded by EFT2; catalyzesribosomal translocation during proteinsynthesis; contains diphthamide, the uniqueposttranslationally modified histidine residuespecifically ADP-ribosylated by diphtheriatoxin 0.005390.09618&radic S000001566YKL083WDubiousDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14 0.005370.09618&radic&radic S000005091LSM7YNL147WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.005390.09618&radic&radic S000000817FAA2YER015WverifiedLong chain fatty acyl-CoA synthetase; accepts a wider range ofacyl chain lengths than Faa1p, preferringC9:0-C13:0; involved in the activation ofendogenous pools of fatty acids 0.005360.09573 S000004842RRP5YMR229CverifiedProtein required for the synthesis of both 18S and 5.8S rRNA;C-terminal region is crucial for the formationof 18S rRNA and N-terminal region is requiredfor the 5.8S rRNA; component of small ribosomalsubunit (SSU) processosome 0.005360.09573 S000000154SHP1YBL058WverifiedUBX (ubiquitin regulatory X) domain-containing protein thatregulates Glc7p phosphatase activity andinteracts with Cdc48p; interacts withubiquitylated proteins in vivo and is requiredfor degradation of a ubiquitylated modelsubstrate 0.005370.09573&radic&radic&radic&radic&radic S000002887PEX29YDR479CverifiedPeroxisomal integral membrane protein, involved in regulationof peroxisome size and number; geneticinteractions suggest that Pex28p and Pex29p actat steps upstream of those mediated by Pex30p,Pex31p, and Pex32p 0.005340.09533&radic S000002625RAD9YDR217CverifiedDNA damage-dependent checkpoint protein, required forcell-cycle arrest in G1/S, intra-S, and G2/M;transmits checkpoint signal by activatingRad53p and Chk1p; hyperphosphorylated by Mec1pand Tel1p; potential Cdc28p substrate 0.00530.09471&radic S000003142BUD13YGL174WverifiedSubunit of the RES complex, which is required for nuclearpre-mRNA retention and splicing; involved inbud-site selection; diploid mutants display aunipolar budding pattern instead of thewild-type bipolar pattern 0.005290.0944&radic S000006027SSE1YPL106CverifiedATPase that is a component of the heat shock protein Hsp90chaperone complex; binds unfolded proteins;member of the heat shock protein 70 (HSP70)family; localized to the cytoplasm 0.005290.0944&radic S000004837MRE11YMR224CverifiedSubunit of a complex with Rad50p and Xrs2p (RMX complex) thatfunctions in repair of DNA double-strand breaksand in telomere stability, exhibits nucleaseactivity that appears to be required for RMXfunction; widely conserved 0.005260.09359&radic S000000521DCC1YCL016CverifiedSubunit of a complex with Ctf8p and Ctf18p that shares somecomponents with Replication Factor C, requiredfor sister chromatid cohesion and telomerelength maintenance 0.005270.09359 S000005153SSB2YNL209WverifiedCytoplasmic ATPase that is a ribosome-associated molecularchaperone, functions with J-protein partnerZuo1p; may be involved in the folding ofnewly-synthesized polypeptide chains; member ofthe HSP70 family; homolog of SSB1 0.005230.09308&radic S000003900HOM6YJR139CverifiedHomoserine dehydrogenase (L-homoserine:NADP oxidoreductase),dimeric enzyme that catalyzes the third step inthe common pathway for methionine and threoninebiosynthesis; enzyme has nucleotide-binding,dimerization and catalytic regions 0.005220.09308&radic S000005180SIN4YNL236WverifiedSubunit of the Mediator complex; interacts with the RNApolymerase II holoenzyme to postively ornegatively regulate transcription; dispensiblefor basal transcription 0.005240.09308&radic S000000482DPB3YBR278WverifiedThird-largest subunit of DNA polymerase II (DNA polymeraseepsilon), required to maintain fidelity ofchromosomal replication and also forinheritance of telomeric silencing; mRNAabundance peaks at the G1/S boundary of thecell cycle 0.00520.09255&radic S000004033TRX1YLR043CverifiedCytoplasmic thioredoxin isoenzyme of the thioredoxin systemwhich protects cells against both oxidative andreductive stress, forms LMA1 complex withPbi2p, acts as a cofactor for Tsa1p, requiredfor ER-Golgi transport and vacuole inheritance 0.005170.09216&radic&radic S000000819AFG3YER017CverifiedComponent, with Yta12p, of the mitochondrial inner membranem-AAA protease that mediates degradation ofmisfolded or unassembled proteins and is alsorequired for correct assembly of mitochondrialenzyme complexes 0.005130.09138&radic S000005241MON2YNL297CverifiedPeripheral membrane protein with a role in endocytosis andvacuole integrity, interacts with Arl1p andlocalizes to the endosome; member of the Sec7pfamily of proteins 0.005130.09138&radic S000000022LTE1YAL024CverifiedPutative GDP/GTP exchange factor required for mitotic exit atlow temperatures; acts as a guanine nucleotideexchange factor (GEF) for Tem1p, which is a keyregulator of mitotic exit; physicallyassociates with Ras2p-GTP 0.005110.09082&radic S000005552BUB3YOR026WverifiedKinetochore checkpoint WD40 repeat protein that localizes tokinetochores during prophase and metaphase,delays anaphase in the presence of unattachedkinetochores; forms complexes with Mad1p-Bub1pand with Cdc20p, binds Mad2p and Mad3p 0.005090.0906&radic&radic S000003131RAD54YGL163CverifiedDNA-dependent ATPase, stimulates strand exchange by modifyingthe topology of double-stranded DNA; involvedin the recombinational repair of double-strandbreaks in DNA during vegetative growth andmeiosis; member of the SWI/SNF family 0.005090.0906&radic S000000897RAD51YER095WverifiedStrand exchange protein, forms a helical filament with DNA thatsearches for homology; involved in therecombinational repair of double-strand breaksin DNA during vegetative growth and meiosis;homolog of Dmc1p and bacterial RecA protein 0.005080.09053&radic S000001448MSL1YIR009WverifiedU2B component of U2 snRNP, involved in splicing, binds the U2snRNA stem-loop IV in vitro; does not containthe conserved C-terminal RNA binding domainfound in other family members 0.005080.09041&radic S000005242CLA4YNL298WverifiedCdc42p activated signal transducing kinase of the PAK(p21-activated kinase) family, involved inseptin ring assembly and cytokinesis; directlyphosphorylates septins Cdc3p and Cdc10p; otheryeast PAK family members are Ste20p and Skm1p 0.005070.0901&radic&radic&radic S000004100CCW12YLR110CverifiedCell wall protein, mutants are defective in mating andagglutination, expression is downregulated byalpha-factor 0.005070.0901&radic S000004022RAD5YLR032WverifiedSingle-stranded DNA-dependent ATPase, involved inpostreplication repair; contains RING fingerdomain 0.005060.09007&radic S000000184TEL1YBL088CverifiedProtein kinase primarily involved in telomere lengthregulation; contributes to cell cyclecheckpoint control in response to DNA damage;functionally redundant with Mec1p; homolog ofhuman ataxia telangiectasia (ATM) gene 0.005030.08945&radic S000002217RAD59YDL059CverifiedProtein involved in the repair of double-strand breaks in DNAduring vegetative growth via recombination andsingle-strand annealing; anneals complementarysingle-stranded DNA; homologous to Rad52p 0.005030.08945&radic S000001537DEF1YKL054CverifiedRNAPII degradation factor, forms a complex with Rad26p inchromatin, enables ubiquitination andproteolysis of RNAPII present in an elongationcomplex 0.004980.08871&radic&radic&radic&radic&radic S000002171HEX3YDL013WverifiedProtein containing a RING finger domain that interacts withSlx8p; mutant phenotypes and geneticinteractions suggest a role in sumoylation andin genome stability 0.004930.08755&radic S000000966CHD1YER164WverifiedNucleosome remodeling factor that functions in regulation oftranscription elongation; contains a chromodomain, a helicase domain and a DNA-bindingdomain; component of both the SAGA and SILKcomplexes 0.004910.08736 S000006134LEA1YPL213WverifiedComponent of U2 snRNP; disruption causes reduced U2 snRNPlevels; physically interacts with Msl1p;invovled in telomere maintenance; putativehomolog of human U2A' snRNP protein 0.004910.08701&radic&radic&radic S000005246RPS19BYNL302CverifiedProtein component of the small (40S) ribosomal subunit,required for assembly and maturation of pre-40S particles; mutations in human RPS19 areassociated with Diamond Blackfan anemia; nearlyidentical to Rps19Ap 0.004850.08591&radic&radic&radic S000003804POL32YJR043CverifiedThird subunit of DNA polymerase delta, involved in chromosomalDNA replication; required for error-prone DNAsynthesis in the presence of DNA damage andprocessivity; interacts with Hys2p, PCNA(Pol30p), and Pol1p 0.004860.08591&radic S000001444IST3YIR005WverifiedComponent of the U2 snRNP, required for the first catalyticstep of splicing and for spliceosomal assembly;interacts with Rds3p and is required forMer1p-activated splicing 0.004880.08591&radic S000004460YPT7YML001WverifiedGTPase; GTP-binding protein of the rab family; required forhomotypic fusion event in vacuole inheritance,for endosome-endosome fusion, similar tomammalian Rab7 0.004830.0855&radic&radic&radic&radic&radic&radic S000000011DEP1YAL013WverifiedTranscriptional modulator involved in regulation of structuralphospholipid biosynthesis genes andmetabolically unrelated genes, as well asmaintenance of telomeres, mating efficiency,and sporulation 0.00480.08512&radic S000004651CSM3YMR048WverifiedProtein required for accurate chromosome segregation duringmeiosis 0.004790.08492 S000006130IPL1YPL209CverifiedAurora kinase involved in regulating kinetochore-microtubuleattachments; helps maintain condensedchromosomes during anaphase and earlytelophase; associates with Sli15p, whichpromotes Ipl1p association with mitotic spindle 0.004790.08492 S000001012OPI1YHL020CverifiedTranscriptional regulator of a variety of genes;phosphorylation by protein kinase A stimulatesOpi1p function in negative regulation ofphospholipid biosynthetic genes; involved intelomere maintenance 0.00480.08492 S000005115YNL171CDubiousHypothetical protein 0.004780.08479&radic&radic S000004775PAH1YMR165CverifiedMg2+-dependent phosphatidate (PA) phosphatase,catalyzes the dephosphorylation of PA to yielddiacylglycerol and Pi, responsiblefor de novo lipid synthesis; homologous tomammalian lipin 1 0.004780.08405&radic S000004181PEX13YLR191WverifiedIntegral peroxisomal membrane receptor for the PTS1 peroxisomalmatrix protein signal recognition factor Pex5p,required for the translocation of peroxisomalmatrix proteins, also interacts with Pex7p andPex14p, contains a C-terminal SH3 domain 0.004770.08405&radic&radic S000000787CIN8YEL061CverifiedKinesin motor protein involved in mitotic spindle assembly andchromosome segregation 0.00470.08283&radic&radic S000005274RPD3YNL330CverifiedHistone deacetylase; regulates transcription and silencing 0.004610.08177&radic&radic S000003793CPR7YJR032WverifiedPeptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzesthe cis-trans isomerization of peptide bondsN-terminal to proline residues; binds to Hsp82pand contributes to chaperone activity 0.004610.08151&radic&radic S000002789YRA1YDR381WverifiedNuclear protein that binds to RNA and to Mex67p, required forexport of poly(A)+ mRNA from the nucleus;member of the REF (RNA and export factorbinding proteins) family; another familymember, Yra2p, can substitute for Yra1pfunction 0.00460.08151&radic S000003120YGL152CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W 0.00460.08151 S000005372HTZ1YOL012CverifiedHistone variant H2AZ, exchanged for histone H2A in nucleosomesby the SWR1 complex; involved intranscriptional regulation through preventionof the spread of silent heterochromatin 0.004580.08104&radic S000003413TIM13YGR181WverifiedMitochondrial intermembrane space protein, forms a complex withTIm8p that mediates import and insertion of asubset of polytopic inner membrane proteins;may prevent aggregation of incoming proteins ina chaperone-like manner 0.004570.08104&radic&radic S000004421CRN1YLR429WverifiedCoronin, cortical actin cytoskeletal component that associateswith the Arp2p/Arp3p complex to regulate itsactivity 0.004520.08004 S000006161HSP82YPL240CverifiedCytoplasmic chaperone (Hsp90 family) required for pheromonesignaling and negative regulation of Hsf1p;docks with the mitochondrial import receptorTom70p for preprotein delivery; interacts withco-chaperones Cns1p, Cpr6p, Cpr7p, and Sti1p 0.004510.07942&radic&radic&radic S000004081YLR091WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR091W is not an esssential gene 0.004510.07942&radic S000005273PEX6YNL329CverifiedPeroxisomal membrane AAA-family ATPase peroxin required forperoxisome assembly, contains two 230 aminoacid ATP-binding AAA cassettes, interacts withPex1p 0.004520.07942&radic S000005383IFM1YOL023WverifiedMitochondrial translation initiation factor 2 0.004490.07942&radic&radic S000004628PEX12YMR026CverifiedRING-finger peroxisomal membrane peroxin that plays anessential role in peroxisome biogenesis andperoxisomal matrix protein import, formstranslocation subcomplex with Pex2p and Pex10p 0.004460.07894&radic&radic S000000566MRC1YCL061CverifiedS-phase checkpoint protein found at replication forks, requiredfor DNA replication; also required for Rad53pactivation during DNA replication stress, whereit forms a replication-pausing complex withTof1p and is phosphorylated by Mec1p; proteininvolved in replication checkpoint 0.004480.07894&radic S000002619GCD6YDR211WverifiedCatalytic epsilon subunit of the translation initiation factoreIF2B, the guanine-nucleotide exchange factorfor eIF2; activity subsequently regulated byphosphorylated eIF2; first identified as anegative regulator of GCN4 expression 0.004460.0785&radic&radic S000005816SNF2YOR290CverifiedCatalytic subunit of the SWI/SNF chromatin remodeling complexinvolved in transcriptional regulation;contains DNA-stimulated ATPase activity;functions interdependently in transcriptionalactivation with Snf5p and Snf6p 0.004440.07839&radic S000003783LSM8YJR022WverifiedLsm (Like Sm) protein; forms heteroheptameric complex (withLsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p)that is part of spliceosomal U6 snRNP and isalso implicated in processing of pre-tRNA,pre-snoRNA, and pre-rRNA 0.004440.07839&radic S000003665TRK1YJL129CverifiedComponent of the Trk1p-Trk2p potassium transport system; 180kDa high affinity potassium transporter;phosphorylated in vivo and interacts physicallywith the phosphatase Ppz1p, suggesting Trk1pacitivy is regulated by phosphorylation 0.004440.0782&radic S000003905MGM101YJR144WverifiedProtein involved in mitochondrial genome maintenance; componentof the mitochondrial nucleoid, required for therepair of oxidative mtDNA damage 0.004430.0782 S000006303YPR099CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W 0.004420.07804 S000003016RPT6YGL048CverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; bound byubiquitin-protein ligases Ubr1p and Ufd4p;localized mainly to the nucleus throughout thecell cycle 0.004420.07804 S000005599SGO1YOR073WverifiedComponent of the spindle checkpoint, involved in sensing lackof tension on mitotic chromosomes; protectscentromeric Rec8p at meiosis I; required foraccurate chromosomal segregation at meiosis IIand for mitotic chromosome stability 0.004380.07716 S000006099CBC2YPL178WverifiedSmall subunit of the heterodimeric cap binding complex thatalso contains Sto1p, component of thespliceosomal commitment complex; interacts withNpl3p, possibly to package mRNA for export fromthe nucleus; contains an RNA-binding motif 0.004420.07716&radic&radic S000004312MMS22YLR320WverifiedProtein involved in resistance to ionizing radiation; acts withMms1p in a repair pathway that may be involvedin resolving replication intermediates orpreventing the damage caused by blockedreplication forks 0.004380.07712&radic&radic S000000180CDC27YBL084CverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 0.004370.07712&radic&radic S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.004370.07665 S000003719MNN11YJL183WverifiedSubunit of a Golgi mannosyltransferase complex that alsocontains Anp1p, Mnn9p, Mnn10p, and Hoc1p, andmediates elongation of the polysaccharidemannan backbone; has homology to Mnn10p 0.004370.07665 S000004885SCS7YMR272CverifiedSphingolipid alpha-hydroxylase, functions in thealpha-hydroxylation of sphingolipid-associatedvery long chain fatty acids, has bothcytochrome b5-like and hydroxylase/desaturasedomains, not essential for growth 0.004360.07665 S000000816HEM14YER014WverifiedProtoporphyrinogen oxidase, a mitochondrial enzyme thatcatalyzes the seventh step in the hemebiosynthetic pathway, convertingprotoporphyrinogen IX to protoporphyrin IX 0.004350.07665&radic S000000449ISW1YBR245CverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPase thatforms a complex with Ioc2p and Ioc4p toregulate transcription elongation, and acomplex with Ioc3p to repress transcriptioninitiation 0.004360.07665 S000005306SNF12YNR023Wverified73 kDa subunit of the SWI/SNF chromatin remodeling complexinvolved in transcriptional regulation; homologof Rsc6p subunit of the RSC chromatinremodeling complex; deletion mutants aretemperature-sensitive 0.004370.07665 S000004045SPT8YLR055CverifiedSubunit of the SAGA transcriptional regulatory complex but notpresent in SAGA-like complex SLIK/SALSA,required for SAGA-mediated inhibition at somepromoters 0.004340.07638&radic S000005596GYP1YOR070CverifiedCis-golgi GTPase-activating protein (GAP) for the Rab familymembers Ypt1p (in vivo) and for Ypt1p, Sec4p,Ypt7p, and Ypt51p (in vitro); involved invesicle docking and fusion 0.004350.07638&radic&radic S000005215BNI1YNL271CverifiedFormin, nucleates the formation of linear actin filaments,involved in cell processes such as budding andmitotic spindle orientation which require theformation of polarized actin cables,functionally redundant with BNR1 0.004350.07638&radic&radic&radic&radic S000000803MNN1YER001WverifiedAlpha-1,3-mannosyltransferase, integral membrane glycoproteinof the Golgi complex, required for addition ofalpha1,3-mannose linkages to N-linked andO-linked oligosaccharides, one of five S.cerevisiae proteins of the MNN1 family 0.004330.07634 S000000051PEX22YAL055WverifiedPutative peroxisomal membrane protein required for import ofperoxisomal proteins, functionally complementsa Pichia pastoris pex22 mutation 0.004330.07619&radic&radic S000004342ORM2YLR350WverifiedEvolutionarily conserved protein with similarity to Orm1p,required for resistance to agents that inducethe unfolded protein response; human orthologis located in the endoplasmic reticulum 0.004320.07597&radic S000004057PET309YLR067CverifiedSpecific translational activator for the COX1 mRNA, alsoinfluences stability of intron-containing COX1primary transcripts; located in themitochondrial inner membrane 0.004320.07597 S000004138PEP3YLR148WverifiedVacuolar peripheral membrane protein that promotes vesiculardocking/fusion reactions in conjunction withSNARE proteins, required for vacuolarbiogenesis, forms complex with Pep5p thatmediates protein transport to the vacuole 0.004310.07593&radic&radic S000001129YHR087WVerifiedProtein involved in RNA metabolism, one of two yeast homologs (with Sdo1p/Ylr022cp) of the human protein SBDS responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome, also conserved in Archaea 0.004310.0757&radic S000005041PHO23YNL097CverifiedProbable component of the Rpd3 histone deacetylase complex,involved in transcriptional regulation of PHO5;C-terminus has similarity to human candidatetumor suppressor p33(ING1) 0.004310.0757 S000000316CYC8YBR112CverifiedGeneral transcriptional co-repressor, acts together with Tup1p;also acts as part of a transcriptionalco-activator complex that recruits the SWI/SNFand SAGA complexes to promoters 0.00430.0757 S000004900DSS1YMR287CverifiedRNase, component of the mitochondrial degradosome along withthe ATP-dependent RNA helicase Suv3p; thedegradosome associates with the ribosome andmediates turnover of aberrant or unprocessedRNAs 0.004310.0757&radic S000002301CRD1YDL142CverifiedCardiolipin synthase; produces cardiolipin, which is animportant constituent of mitochondrialmembranes; required for normal mitochondrialmembrane potential and function 0.004280.0753 S000001808SKG1YKR100CuncharacterizedTransmembrane protein of unknown function; localizes on theinner surface of the plasma membrane at the budand in the daughter cell; affects the cell wallpolymer composition 0.004290.0753 S000002561YDR154CDubiousHypothetical protein 0.004280.07492&radic S000003746PEX2YJL210WverifiedRING-finger peroxin, peroxisomal membrane protein with aC-terminal zinc-binding RING domain, formsputative translocation subcomplex with Pex10pand Pex12p which functions in peroxisomalmatrix protein import 0.004270.07492&radic&radic S000006103YPL182CDubiousHypothetical protein 0.004270.07492&radic S000003365PEX4YGR133WverifiedPeroxisomal ubiquitin conjugating enzyme required forperoxisomal matrix protein import andperoxisome biogenesis 0.004260.07492&radic S000003150YGL182CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MND1/YGL183C 0.004260.07492 S000002971CDH1YGL003CverifiedCell-cycle regulated activator of the anaphase-promotingcomplex/cyclosome (APC/C), which directsubiquitination of mitotic cyclins resulting inexit from mitosis; targets the APC/C tospecific substrates including CDC20, ASE1 andCIN8 0.004260.07492&radic S000000889YER087WUncharacterizedHypothetical protein 0.004270.07492&radic&radic S000001237MDM31YHR194WverifiedMitochondrial inner membrane protein with similarity to Mdm32p,required for normal mitochondrial morphologyand inheritance; interacts genetically withMMM1, MDM10, MDM12, and MDM34 0.004250.07465 S000003056YGL088WDubiousHypothetical protein 0.004250.07465 S000006280YPR076WDubiousHypothetical protein 0.004250.07465 S000005158PEX17YNL214WverifiedPeroxisomal membrane protein component of the peroxisomaltranslocation machinery, required forperoxisome biogenesis, binds Pex14p 0.004220.07393&radic S000003491YGR259CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W 0.004210.07393&radic&radic S000002847LRS4YDR439WverifiedProtein involved in rDNA silencing; positively chargedcoiled-coil protein with limited similarity tomyosin 0.00420.07346 S000005835SNU66YOR308CverifiedComponent of the U4/U6.U5 snRNP complex involved in pre-mRNAsplicing via spliceosome; has homology to humanSART-1 and to an S. pombe protein; snu66 nullmutation confers cold-sensitivity but is notlethal at normal growth temperatures 0.00420.07346&radic S000000763RAD23YEL037CverifiedProtein with ubiquitin-like N terminus, recognizes and bindsdamaged DNA (with Rad4p) during nucleotideexcision repair; regulates Rad4p levels,subunit of Nuclear Excision Repair Factor 2(NEF2); homolog of human HR23A and HR23Bproteins 0.004180.0733&radic S000002711RSC3YDR303CverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; essential gene required forregulation of ribosomal protein genes and thecell wall/stress response; highly similar toRsc30p 0.004170.07314&radic S000001142YHR100CUncharacterizedPutative protein of unknown function; exhibits growth defect on a non-fermentable (respiratory) carbon source; YHR100C is not an essential gene 0.004180.07314&radic S000004140STM1YLR150WverifiedProtein that binds G4 quadruplex and purine motif triplexnucleic acid; acts with Cdc13p to maintaintelomere structure; interacts with ribosomesand subtelomeric Y' DNA; multicopy suppressorof tom1 and pop2 mutations 0.004150.07262&radic&radic&radic S000003848YJR088CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum 0.004160.07262 S000000377UMP1YBR173CverifiedShort-lived chaperone required for correct maturation of the20S proteasome; degraded by proteasome uponcompletion of its assembly; involved inubiquitin-mediated proteolysis; mutantdefective in degradation of short-livedproteins 0.004150.07262&radic&radic&radic&radic&radic S000004436YLR444CDubiousHypothetical protein 0.004140.07247 S000003798YJR037WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; YJR037W is not an essential gene. 0.004140.07247 S000000118PIM1YBL022CverifiedMitochondrial ATP-dependent protease involved inintramitochondrial proteolysis; involved indegradation of misfolded proteins inmitochondria; required for bigenesis andmaintenance of mitochondria 0.004150.07247&radic S000000551YCL046WDubiousHypothetical protein 0.004140.07247 S000004388VPS33YLR396CverifiedATP-binding protein that is a subunit of the homotypic vacuolefusion and vacuole protein sorting (HOPS)complex; essential for membrane docking andfusion at both the Golgi-to-endosome andendosome-to-vacuole stages of protein transport 0.004120.07191&radic&radic S000000924GLO3YER122CverifiedADP-ribosylation factor GTPase activating protein (ARF GAP),involved in ER-Golgi transport; sharesfunctional similarity with Gcs1p 0.004120.07191 S000000935GLC7YER133WverifiedCatalytic subunit of type 1 serine/threonine proteinphosphatase, involved in many processesincluding glycogen metabolism, sporulation, andmitosis; interacts with multiple regulatorysubunits; predominantly isolated with Sds22p 0.004120.07191&radic S000005673MDM32YOR147WverifiedMitochondrial inner membrane protein with similarity to Mdm31p,required for normal mitochondrial morphologyand inheritance; interacts genetically withMMM1, MDM10, MDM12, and MDM34 0.004130.07191 S000003121PEX14YGL153WverifiedPeroxisomal membrane protein that is a central component of theperoxisomal protein import machinery, interactswith PTS1 (Pex5p) and PTS2 (Pex7p) peroxisomalmatrix protein signal recognition factors andmembrane receptor Pex13p 0.00410.07147 S000005853MYO2YOR326WverifiedOne of two type V myosin motors (along with MYO4) involved inactin-based transport of cargos; required forthe polarized delivery of secretory vesicles,the vacuole, late Golgi elements, peroxisomes,and the mitotic spindle 0.004110.07147&radic&radic S000002232BRE1YDL074CverifiedE3 ubiquitin ligase for Rad6p, required for the ubiquitinationof histone H2B, recruitment of Rad6p topromoter chromatin and subsequent methylationof histone H3 (on L4 and L79), contains RINGfinger domain 0.004090.07136&radic S000002800SPT3YDR392WverifiedSubunit of the SAGA and SAGA-like transcriptional regulatorycomplexes, interacts with Spt15p to activatetranscription of some RNA polymeraseII-dependent genes, also functions to inhibittranscription at some promoters 0.004070.07091&radic S000002673PEX10YDR265WverifiedRING finger peroxisomal membrane peroxin required forperoxisomal matrix protein import, interactswith Pex12p, links ubiquitin-conjugating Pex4pto protein import machinery; mutations in humanhomolog cause a variety of peroxisomaldisorders 0.004070.07091&radic S000005028END3YNL084CverifiedEH domain-containing protein involved in endocytosis, actincytoskeletal organization and cell wallmorphogenesis; forms a complex with Sla1p andPan1p 0.004060.07023 S000004362ARC18YLR370CverifiedSubunit of the ARP2/3 complex, which is required for themotility and integrity of cortical actinpatches 0.004040.07023 S000001346SDS3YIL084CverifiedComponent of the Rpd3p/Sin3p deacetylase complex required forits structural integrity and catalyticactivity, involved in transcriptional silencingand required for sporulation; cells defectivein SDS3 display pleiotropic phenotypes 0.004060.07023 S000003086YGL118CDubiousHypothetical protein 0.004020.06974&radic S000006148ALG5YPL227CverifiedUDP-glucose:dolichyl-phosphate glucosyltransferase, involved inasparagine-linked glycosylation in theendoplasmic reticulum 0.004010.06962&radic S000000372PEX32YBR168WverifiedPeroxisomal integral membrane protein, involved in negativeregulation of peroxisome size; partiallyfunctionally redundant with Pex31p; geneticinteractions suggest action at a stepdownstream of steps mediated by Pex28p andPex29p 0.0040.06947 S000004349RSC2YLR357WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; involvedin telomere maintenance 0.003970.06884&radic S000002505GRX3YDR098CverifiedHydroperoxide and superoxide-radical responsiveglutathione-dependent oxidoreductase; monothiolglutaredoxin subfamily member along with Grx4pand Grx5p; protects cells from oxidative damage 0.003950.06833&radic S000001093COX6YHR051WverifiedSubunit VI of cytochrome c oxidase, which is the terminalmember of the mitochondrial inner membraneelectron transport chain; expression isregulated by oxygen levels 0.003960.06833&radic S000001900RPN11YFR004WverifiedMetalloprotease subunit of the 19S regulatory particle of the26S proteasome lid; couples thedeubiquitination and degradation of proteasomesubstrates 0.003970.06833&radic&radic S000004844PEP5YMR231WverifiedPeripheral vacuolar membrane protein required for proteintrafficking and vacuole biogenesis; formscomplex with Pep3p that promotes vesiculardocking/fusion reactions in conjunction withSNARE proteins, also interacts with Pep7p 0.003940.06823&radic S000006373JIP5YPR169WuncharacterizedNucleolar protein of unknown function, exhibits a physicalinteraction with Bre1p 0.003940.06802&radic&radic S000005014TOM7YNL070WverifiedComponent of the TOM (translocase of outer membrane) complexresponsible for recognition and initial importsteps for all mitochondrially directedproteins; promotes assembly and stability ofthe TOM complex 0.003930.06802 S000003309PEX8YGR077CverifiedIntraperoxisomal organizer of the peroxisomal import machinery,tightly associated with the lumenal face of theperoxisomal membrane, essential for peroxisomebiogenesis, binds PTS1-signal receptor Pex5p 0.003930.06802&radic S000003355PPT1YGR123CverifiedProtein serine/threonine phosphatase with similarity to humanphosphatase PP5; present in both the nucleusand cytoplasm; expressed during logarithmicgrowth 0.003920.06757&radic S000002205SIT4YDL047WverifiedType 2A-related serine-threonine phosphatase that functions inthe G1/S transition of the mitotic cycle;cytoplasmic and nuclear protein that modulatesfunctions mediated by Pkc1p including cell walland actin cytoskeleton organization 0.00390.06723&radic S000000046GEM1YAL048CverifiedEvolutionarily-conserved tail-anchored outer mitochondrialmembrane GTPase which regulates mitochondrialmorphology; cells lacking Gem1p containcollapsed, globular, or grape-likemitochondria; not required forpheromone-induced cell death 0.003880.06684&radic S000000823RPN3YER021WverifiedEssential, non-ATPase regulatory subunit of the 26S proteasomelid, similar to the p58 subunit of the human26S proteasome; temperature-sensitive allelescause metaphase arrest, suggesting a role forthe proteasome in cell cycle control 0.003880.06684&radic&radic S000003583RTT101YJL047CverifiedCullin subunit of a Roc1p-dependent E3 ubiquitin ligasecomplex; deletion phenotype suggests a role inanaphase progression; interacts with Mms22p andimplicated in Mms22-dependent DNA repair;modified by the ubiquitin-like protein, Rub1p 0.003870.06651&radic S000003111MRF1YGL143CverifiedMitochondrial polypeptide chain release factor, involved instop codon recognition and hydrolysis of thepeptidyl-tRNA bond during mitochondrialtranslation; lack of MRF1 causes mitochondrialgenome instability 0.003870.06651 S000005000POR1YNL055CverifiedMitochondrial porin (voltage-dependent anion channel), outermembrane protein required for the maintenanceof mitochondrial osmotic stability andmitochondrial membrane permeability 0.003850.06597&radic S000000264ORC2YBR060CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing; may be phosphorylated by Cdc28p 0.003850.06597&radic S000004759YIM2YMR151WdubiousDubious open reading frame, unlikely to encode a protein; notconserved in closely related Saccharomycesspecies; 5% of ORF overlaps the verified geneIMP1 0.003820.06528&radic&radic S000005872YOR345CDubiousHypothetical protein 0.00380.06498 S000000286UBC4YBR082CverifiedUbiquitin-conjugating enzyme that mediates degradation ofshort-lived and abnormal proteins; interactswith E3-CaM in ubiquitinating calmodulin;interacts with many SCF ubiquitin proteinligases; component of the cellular stressresponse 0.00380.06498&radic S000003156YGL188CDubiousHypothetical protein 0.00380.06498 S000003013RIM8YGL045WverifiedProtein of unknown function, involved in the proteolyticactivation of Rim101p in response to alkalinepH; has similarity to A. nidulans PalF 0.003790.06486&radic&radic S000006119RPL7BYPL198WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl7Ap and has similarity to E.coli L30 and rat L7 ribosomal proteins;contains a conserved C-terminal Nucleic acidBinding Domain (NDB2) 0.003790.06486&radic&radic S000005587CKA2YOR061WverifiedAlpha' catalytic subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKB1 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.003780.06458&radic&radic S000005724BFR1YOR198CverifiedComponent of mRNP complexes associated with polyribosomes;implicated in secretion and nuclearsegregation; multicopy suppressor of BFA(Brefeldin A) sensitivity 0.003780.06458&radic S000003563RNR2YJL026WverifiedRibonucleotide-diphosphate reductase (RNR), small subunit; theRNR complex catalyzes the rate-limiting step indNTP synthesis and is regulated by DNAreplication and DNA damage checkpoint pathwaysvia localization of the small subunits 0.003770.06405&radic&radic S000006345KAR3YPR141CverifiedMinus-end-directed microtubule motor that functions in mitosisand meiosis, localizes to the spindle pole bodyand localization is dependent on functionalCik1p, required for nuclear fusion duringmating; potential Cdc28p substrate 0.003750.06405&radic S000000552YCL047CUncharacterizedPutative protein of unknown function 0.003750.06405&radic S000002564YDR157WDubiousHypothetical protein 0.003760.06405 S000005888PRT1YOR361CverifiedSubunit of the core complex of translation initiation factor3(eIF3), essential for translation; part of asubcomplex (Prt1p-Rpg1p-Nip1p) that stimulatesbinding of mRNA and tRNA(i)Met to ribosomes 0.003750.06391&radic&radic S000001696DOA1YKL213CverifiedWD repeat protein required for ubiquitin-mediated proteindegradation, forms complex with Cdc48p, plays arole in controlling cellular ubiquitinconcentration; also promotes efficient NHEJ inpostdiauxic/stationary phase 0.003740.06362&radic&radic&radic S000004620YMR018WUncharacterizedPutative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene 0.003740.06362 S000002905ITR1YDR497CverifiedMyo-inositol transporter with strong similarity to the minormyo-inositol transporter Itr2p, member of thesugar transporter superfamily; expression isrepressed by inositol and choline via Opi1p andderepressed via Ino2p and Ino4p 0.003740.06362 S000000815PRP22YER013WverifiedDEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase,associates with lariat intermediates before thesecond catalytic step of splicing; mediatesATP-dependent mRNA release from the spliceosomeand unwinds RNA duplexes 0.003720.0633&radic&radic S000006261BRR1YPR057WverifiedsnRNP protein component of spliceosomal snRNPs, required forpre-mRNA splicing and snRNP biogenesis; in nullmutant newly-synthesized snRNAs aredestabilized and 3'-end processing is slowed 0.003720.0633 S000001756NAP1YKR048CverifiedProtein that interacts with mitotic cyclin Clb2p; required forthe regulation of microtubule dynamics duringmitosis; controls bud morphogenesis; involvedin the transport of H2A and H2B histones to thenucleus 0.003710.06303&radic S000004802SGS1YMR190CverifiedNucleolar DNA helicase of the RecQ family involved inmaintenance of genome integrity, regulateschromosome synapsis and meiotic crossing over;has similarity to human BLM and WRN helicasesimplicated in Bloom and Werner syndromes 0.003680.06252&radic S000000215IPP1YBR011CverifiedCytoplasmic inorganic pyrophosphatase (PPase), catalyzes therapid exchange of oxygens from Pi with water,highly expressed and essential for viability,active-site residues show identity to thosefrom E. coli PPase 0.003670.06239&radic S000005528ALG6YOR002WverifiedGlucosyltransferase, involved in transfer of oligosaccharidesfrom dolichyl pyrophosphate to asparagineresidues of proteins during N-linked proteinglycosylation; mutations in human ortholog areassociated with disease 0.003650.06203&radic&radic&radic S000002728SWA2YDR320CverifiedAuxilin-like protein involved in vesicular transport;clathrin-binding protein required for uncoatingof clathrin-coated vesicles 0.003650.06199&radic S000000393RPS9BYBR189WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps9Ap and has similarity to E.coli S4 and rat S9 ribosomal proteins 0.003640.06171&radic S000003441TRX2YGR209CverifiedCytoplasmic thioredoxin isoenzyme of the thioredoxin systemwhich protects cells against both oxidative andreductive stress, forms LMA1 complex withPbi2p, acts as a cofactor for Tsa1p, requiredfor ER-Golgi transport and vacuole inheritance 0.003640.06171&radic&radic S000002483RAD55YDR076WverifiedProtein that stimulates strand exchange by stabilizing thebinding of Rad51p to single-stranded DNA;involved in the recombinational repair ofdouble-strand breaks in DNA during vegetativegrowth and meiosis; forms heterodimer withRad57p 0.003640.06171&radic S000002580ARG82YDR173CverifiedInositol polyphosphate multikinase (IPMK), sequentiallyphosphorylates Ins(1,4,5)P3 to formIns(1,3,4,5,6)P5; putative nuclear lipidinositol PI3-kinase; regulates arginine-,phosphate-, and nitrogen-responsive genes 0.003620.06137&radic&radic&radic S000006367TIF3YPR163CverifiedTranslation initiation factor eIF-4B, has RNA annealingactivity; contains an RNA recognition motif andbinds to single-stranded RNA 0.003620.06137&radic&radic S000006312RPN7YPR108WverifiedEssential, non-ATPase regulatory subunit of the 26S proteasome,similar to another S. cerevisiae regulatorysubunit, Rpn5p, as well as to mammalianproteasome subunits 0.003590.06082&radic&radic S000001083SRB2YHR041CverifiedGeneral transcription factor, subunit of the RNA polymerase IImediator complex; associates with corepolymerase subunits to form the RNA polymeraseII holoenzyme; involved in telomere maintenance 0.003540.05968&radic&radic&radic S000005845YOR318CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo 0.003570.05968&radic S000002207KNH1YDL049CverifiedProtein with similarity to Kre9p, which is involved in cellwall beta 1,6-glucan synthesis; overproductionsuppresses growth defects of a kre9 null mutant 0.003560.05968 S000004009PSR2YLR019WverifiedFunctionally redundant Psr1p homolog, a plasma membranephosphatase involved in the general stressresponse; required with Psr1p and Whi2p forfull activation of STRE-mediated geneexpression, possibly through dephosphorylationof Msn2p 0.003590.05968&radic S000002419RPL4BYDR012WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl4Ap and has similarity to E.coli L4 and rat L4 ribosomal proteins 0.003570.05968&radic S000000673PAT1YCR077CverifiedTopoisomerase II-associated deadenylation-dependentmRNA-decapping factor; also required forfaithful chromosome transmission, maintenanceof rDNA locus stability, and protection of mRNA3'-UTRs from trimming; functionally linked toPab1p 0.003560.05968&radic&radic&radic&radic S000002411RAD57YDR004WverifiedProtein that stimulates strand exchange by stabilizing thebinding of Rad51p to single-stranded DNA;involved in the recombinational repair ofdouble-strand breaks in DNA during vegetativegrowth and meiosis; forms heterodimer withRad55p 0.003540.05968&radic S000003054MAD1YGL086WverifiedCoiled-coil protein involved in the spindle-assemblycheckpoint; phosphorylated by Mps1p uponcheckpoint activation which leads to inhibitionof the activity of the anaphase promotingcomplex; forms a complex with Mad2p 0.003560.05968 S000002718SUM1YDR310CverifiedTranscriptional repressor required for mitotic repression ofmiddle sporulation-specific genes; involved intelomere maintenance, regulated by thepachytene checkpoint 0.003570.05968 S000002506BMH2YDR099Wverified14-3-3 protein, minor isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others 0.003520.05954&radic&radic&radic S000004395SFP1YLR403WverifiedTranscription factor that controls expression of many ribosomebiogenesis genes in response to nutrients andstress, regulates G2/M transitions duringmitotic cell cycle and DNA-damage response,involved in cell size modulation 0.003520.05925&radic&radic&radic S000002740IRC3YDR332WuncharacterizedHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 0.003490.05888 S000003180VAM7YGL212WverifiedComponent of the vacuole SNARE complex involved in vacuolarmorphogenesis; SNAP-25 homolog; functions witha syntaxin homolog Vam3p in vacuolar proteintrafficking 0.003490.05888&radic&radic&radic&radic&radic S000006361YPR157WUncharacterizedPutative protein of unknown function 0.003490.05888 S000001052RPL27AYHR010WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl27Bp and has similarity to ratL27 ribosomal protein 0.003480.05872&radic&radic&radic&radic&radic S000003278TAM41YGR046WverifiedMitochondrial protein involved in protein import into themitochondrial matrix; maintains the functionalintegrity of the TIM23 protein translocatorcomplex; viability of null mutant isstrain-dependent; mRNA is targeted to the bud 0.003470.05863 S000001082BCD1YHR040WverifiedEssential protein required for the accumulation of box C/DsnoRNA 0.003450.05833&radic&radic S000002581HMO1YDR174WverifiedChromatin associated high mobility group (HMG) family memberinvolved in genome maintenance; rDNA-bindingcomponent of the Pol I transcription system;associates with a 5'-3' DNA helicase and Fpr1p,a prolyl isomerase 0.003440.05808&radic&radic S000001602VPH2YKL119CverifiedIntegral membrane protein required for vacuolar H+-ATPase(V-ATPase) function, although not an actualcomponent of the V-ATPase complex; functions inthe assembly of the V-ATPase; localized to theendoplasmic reticulum (ER) 0.003450.05808&radic&radic&radic&radic&radic S000001505CDC16YKL022CverifiedSubunit of the anaphase-promoting complex/cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition; required forsporulation 0.003440.05808&radic S000005642RPO31YOR116CverifiedRNA polymerase III subunit C160, part of core enzyme; similarto bacterial beta-prime subunit 0.003440.058&radic&radic S000001564TEF4YKL081WverifiedTranslation elongation factor EF-1 gamma 0.003430.05793&radic&radic S000006256NHP6AYPR052CverifiedHigh-mobility group non-histone chromatin protein, functionallyredundant with Nhp6Bp; homologous to mammalianhigh mobility group proteins 1 and 2; acts torecruit transcription factor Rcs1p to certainpromoters 0.003420.05753 S000006101TCO89YPL180WverifiedSubunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complexthat regulates growth in response to nutrientavailability; cooperates with Ssd1p in themaintenance of cellular integrity; deletionstrains are hypersensitive to rapamycin 0.003420.05753&radic&radic&radic&radic S000005787RPN8YOR261CverifiedEssential, non-ATPase regulatory subunit of the 26S proteasome;has similarity to the human p40 proteasomalsubunit and to another S. cerevisiae regulatorysubunit, Rpn11p 0.003430.05753&radic&radic S000003149GTS1YGL181WverifiedProtein containing a zinc-finger in the N-terminus and a longGln-rich region in the C-terminus; regulatesultradian rhythm, cell size, cell cycle,lifespan, sporulation, heat tolerance, andmultidrug transport 0.003420.05753&radic S000001441MPH1YIR002CverifiedMember of the DEAH family of helicases, functions in anerror-free DNA damage bypass pathway thatinvolves homologous recombination, mutationsconfer a mutator phenotype 0.00340.05744&radic S000001318VHR1YIL056WuncharacterizedTranscriptional activator, required for the vitaminH-responsive element (VHRE) mediated inductionof VHT1 (Vitamin H transporter) and BIO5(biotin biosynthesis intermediate transporter)in response to low biotin concentrations 0.003370.05695&radic&radic S000000513YCL007CDubiousDubious ORF unlikely to encode a protein; overlaps verified ORF YCL005W-A; mutations in YCL007C were thought to confer sensitivity to calcofluor white, but this phenotype was later shown to be due to the defect in YCL005W-A 0.003340.0565&radic&radic&radic&radic S000002451HEM13YDR044WverifiedCoproporphyrinogen III oxidase, an oxygen requiring enzyme thatcatalyzes the sixth step in the hemebiosynthetic pathway; localizes to themitochondrial inner membrane; transcription isrepressed by oxygen and heme (via Rox1p andHap1p) 0.003330.05637&radic S000003749YJL213WUncharacterizedPutative protein of unknown function; periodically expressed during the yeast metabolic cycle; expression induced in respiratory incompetent petite cells; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p 0.003330.05637&radic S000004732STO1YMR125WverifiedLarge subunit of the nuclear mRNA cap-binding protein complex,interacts with Npl3p to carry nuclear poly(A)+mRNA to cytoplasm; also involved in nuclearmRNA degradation and telomere maintenance;orthologous to mammalian CBP80 0.003340.05637 S000006125HRR25YPL204WverifiedProtein kinase involved in regulating diverse events includingvesicular trafficking, gene expression, DNArepair, and chromosome segregation; binds theCTD of RNA pol II; homolog of mammalian caseinkinase 1delta (CK1delta) 0.003330.05627&radic&radic S000002128SBH1YER087C-BverifiedBeta subunit of the Sec61p ER translocation complex(Sec61p-Sss1p-Sbh1p); involved in proteintranslocation into the endoplasmic reticulum;interacts with the exocyst complex; homologousto Sbh2p 0.003320.05621&radic S000002802RPT3YDR394WverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; substrate ofN-acetyltransferase B 0.003320.05621&radic S000001335SPO22YIL073CverifiedMeiosis-specific protein essential for chromosome synapsis,similar to phospholipase A2, involved incompletion of nuclear divisions during meiosis;induced early in meiosis 0.003310.05602&radic S000005035NST1YNL091WverifiedProtein of unknown function, mediates sensitivity to saltstress; interacts physically with the splicingfactor Msl1p and also displays geneticinteraction with MSL1 0.003310.05602&radic S000000462SHG1YBR258CverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres 0.003310.05602&radic&radic S000000186MRP21YBL090WverifiedMitochondrial ribosomal protein of the large subunit; MRP21exhibits genetic interactions with mutations inthe COX2 and COX3 mRNA 5'-untranslated leadersequences 0.00330.05584&radic S000004894GPI12YMR281WverifiedER membrane protein involved in the second step ofglycosylphosphatidylinositol (GPI) anchorassembly, the de-N-acetylation of theN-acetylglucosaminylphosphatidylinositolintermediate; functional homolog of humanPIG-Lp 0.00330.05584&radic&radic&radic S000001370YIL108WUncharacterizedPutative metalloprotease 0.003280.05549&radic S000005105CBK1YNL161WverifiedSerine/threonine protein kinase that regulates cellmorphogenesis pathways; involved in cell wallbiosynthesis, apical growth, proper matingprojection morphology, bipolar bud siteselection in diploid cells, and cell separation 0.003280.05549&radic&radic S000002653MNN10YDR245WverifiedSubunit of a Golgi mannosyltransferase complex also containingAnp1p, Mnn9p, Mnn11p, and Hoc1p that mediateselongation of the polysaccharide mannanbackbone; membrane protein of themannosyltransferase family 0.003290.05549&radic&radic S000001531ELM1YKL048CverifiedSerine/threonine protein kinase that regulates cellularmorphogenesis, septin behavior, andcytokinesis; required for the regulation ofother kinases; forms part of the bud neck ring 0.003290.05549&radic&radic S000004849TAF9YMR236WverifiedSubunit (17 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification, similar to histone H3 0.003280.05549 S000003011DST1YGL043WverifiedGeneral transcription elongation factor TFIIS, enables RNApolymerase II to read through blocks toelongation by stimulating cleavage of nascenttranscripts stalled at transcription arrestsites 0.003280.05549&radic S000004187SIK1YLR197WverifiedEssential evolutionarily-conserved nucleolar protein componentof the box C/D snoRNP complexes that direct2'-O-methylation of pre-rRNA during itsmaturation; overexpression causes spindleorientation defects 0.003270.05519&radic&radic S000000122LSM2YBL026WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.003270.05519&radic&radic S000000777VMA8YEL051WverifiedSubunit D of the eight-subunit V1 peripheral membrane domain ofthe vacuolar H+-ATPase (V-ATPase), anelectrogenic proton pump found throughout theendomembrane system; plays a role in thecoupling of proton transport and ATP hydrolysis 0.003260.05515&radic S000004650NUP116YMR047CverifiedSubunit of the nuclear pore complex (NPC) that is localized toboth sides of the pore; contains a repetitiveGLFG motif that interacts with mRNA exportfactor Mex67p and with karyopherin Kap95p;homologous to Nup100p 0.003250.0551&radic S000004652ERB1YMR049CverifiedProtein required for maturation of the 25S and 5.8S ribosomalRNAs; constituent of 66S pre-ribosomalparticles; homologous to mammalian Bop1 0.003240.05484 S000001066MAS2YHR024CverifiedLarger subunit of the mitochondrial processing protease (MPP),essential processing enzyme that cleaves theN-terminal targeting sequences frommitochondrially imported proteins 0.003210.05462&radic S000002634ADK1YDR226WverifiedAdenylate kinase, required for purine metabolism; localized tothe cytoplasm and the mitochondria; lackscleavable signal sequence 0.003210.05462&radic&radic&radic&radic&radic&radic S000000752SNU13YEL026WverifiedRNA binding protein, part of U3 snoRNP involved in rRNAprocessing, part of U4/U6-U5 tri-snRNP involvedin mRNA splicing, similar to human 15.5Kprotein 0.003210.05462&radic S000005857MIP1YOR330CverifiedCatalytic subunit of the mitochondrial DNA polymerase;conserved C-terminal segment is required forthe maintenance of mitochondrial genome. 0.00320.05395&radic S000006368MMS1YPR164WverifiedProtein likely involved in protection againstreplication-dependent DNA damage; mutants aresensitive to methyl methanesulfonate (MMS);implicated in regulation of Ty1 transposition 0.003190.05395&radic&radic S000005531DNL4YOR005CverifiedDNA ligase required for nonhomologous end-joining (NHEJ), formsstable heterodimer with required cofactorLif1p, catalyzes DNA ligation as part of acomplex with Lif1p and Nej1p; involved inmeiosis, not essential for vegetative growth 0.00320.05395&radic S000004372CSR1YLR380WverifiedPhosphatidylinositol transfer protein with a potential role inlipid turnover; interacts specifically withthioredoxin peroxidase (Tsa2p) and may have arole in oxidative stress resistance 0.003190.05395&radic&radic S000006259SEC8YPR055WverifiedEssential 121kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which has the essential function ofmediating polarized targeting of secretoryvesicles to active sites of exocytosis 0.003190.05395&radic S000000081SWH1YAR042WverifiedProtein similar to mammalian oxysterol-binding protein;contains ankyrin repeats; localizes to theGolgi and the nucleus-vacuole junction 0.003190.05395&radic&radic S000002944STL1YDR536WverifiedGlycerol proton symporter of the plasma membrane, subject toglucose-induced inactivation, strongly buttransiently induced when cells are subjected toosmotic shock 0.00320.05395&radic S000000883SER3YER081Wverified3-phosphoglycerate dehydrogenase, catalyzes the first step inserine and glycine biosynthesis; isozyme ofSer33p 0.003180.05395&radic&radic&radic S000005295URK1YNR012WverifiedUridine/cytidine kinase, component of the pyrimidineribonucleotide salvage pathway that convertsuridine into UMP and cytidine into CMP;involved in the pyrimidine deoxyribonucleotidesalvage pathway, converting deoxycytidine intodCMP 0.003180.05395&radic S000004876SAP30YMR263WverifiedSubunit of a histone deacetylase complex, along with Rpd3p andSin3p, that is involved in silencing attelomeres, rDNA, and silent mating-type loci;involved in telomere maintenance 0.003180.05395&radic S000000796DSF1YEL070WuncharacterizedDeletion suppressor of mpt5 mutation 0.003170.05388 S000000667IMG2YCR071CverifiedMitochondrial ribosomal protein of the small subunit 0.003170.05382&radic S000002258GET3YDL100CverifiedATPase, subunit of the GET complex; required for the retrievalof HDEL proteins from the Golgi to the ER in anERD2 dependent fashion; involved in resistanceto heat and metal stress 0.003160.05373&radic S000001631SDH1YKL148CverifiedFlavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p,Sdh3p, Sdh4p), which couples the oxidation ofsuccinate to the transfer of electrons toubiquinone 0.003160.05373&radic S000005654ADE2YOR128CverifiedPhosphoribosylaminoimidazole carboxylase, catalyzes a step inthe 'de novo' purine nucleotide biosyntheticpathway; red pigment accumulates in mutantcells deprived of adenine 0.003150.05306&radic S000005785RPT4YOR259CverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; required for spindlepole body duplication; localized mainly to thenucleus throughout the cell cycle 0.003120.05306&radic S000002910SAM2YDR502CverifiedS-adenosylmethionine synthetase, catalyzes transfer of theadenosyl group of ATP to the sulfur atom ofmethionine; one of two differentially regulatedisozymes (Sam1p and Sam2p) 0.003130.05306&radic S000004165CBF5YLR175WverifiedPseudouridine synthase catalytic subunit of box H/ACA smallnucleolar ribonucleoprotein particles(snoRNPs), acts on both large and small rRNAsand on snRNA U2 0.003120.05306&radic S000004642SUB1YMR039CverifiedTranscriptional coactivator, facilitates elongation byinfluencing enzymes that modify RNAP II, actsin a peroxide resistance pathway involvingRad2p; suppressor of TFIIB mutations 0.003150.05306&radic S000001790NUP133YKR082WverifiedSubunit of the Nup84p subcomplex of the nuclear pore complex(NPC), localizes to both sides of the NPC,required to establish a normalnucleocytoplasmic concentration gradient of theGTPase Gsp1p 0.003120.05306 S000000756ECM10YEL030WverifiedHeat shock protein of the Hsp70 family, localized inmitochondrial nucleoids, plays a role inprotein translocation, interacts with Mge1p inan ATP-dependent manner; overexpression inducesextensive mitochondrial DNA aggregations 0.003120.05306 S000001732DBP7YKR024CverifiedPutative ATP-dependent RNA helicase of the DEAD-box familyinvolved in ribosomal biogenesis 0.003120.05303&radic&radic S000001524VPS24YKL041WverifiedOne of four subunits of the endosomal sorting complex requiredfor transport III (ESCRT-III); forms anESCRT-III subcomplex with Did4p; involved inthe sorting of transmembrane proteins into themultivesicular body (MVB) pathway 0.003120.05303&radic&radic&radic S000004907YMR293CUncharacterizedPutative protein similar to bacterial glutamyl-tRNA amidotransferases; may be involved in aerobic respiration; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR293C is not an essential gene 0.003120.05303 S000001773PAM17YKR065CverifiedPresequence translocase-associated motor subunit, required forstable complex formation between cochaperonesPam16p and Pam18p, promotes association ofPam16p-Pam18p with the presequence translocase 0.003110.05278&radic S000002772CDC40YDR364CverifiedPre-mRNA splicing factor, important for catalytic step II ofpre-mRNA splicing and plays a role in cellcycle progression; required for DNA synthesisduring mitosis and meiosis; has WD repeats 0.00310.05278&radic&radic&radic&radic S000001069RPN1YHR027CverifiedNon-ATPase base subunit of the 19S regulatory particle of the26S proteasome; may participate in therecognition of several ligands of theproteasome; contains a leucine-rich repeat(LRR) domain, a site for protein?proteininteractions 0.00310.05269&radic&radic S000007488YBL059C-AUncharacterizedHypothetical protein 0.003090.05265&radic S000005583SGT1YOR057WverifiedProbable cochaperone, regulates activity of Cyr1p (adenylylcyclase); involved in assembly of thekinetochore complex, associates with the SCF(Skp1p/Cdc53p/F box protein) ubiquitin ligasecomplex 0.003090.05256&radic&radic S000006290SUA7YPR086WverifiedTranscription factor TFIIB, a general transcription factorrequired for transcription initiation and startsite selection by RNA polymerase II 0.003090.05256 S000004860FAA4YMR246WverifiedLong chain fatty acyl-CoA synthetase, regulates proteinmodification during growth in the presence ofethanol, functions to incorporate palmitic acidinto phospholipids and neutral lipids 0.003090.05256&radic S000002306RPN5YDL147WverifiedEssential, non-ATPase regulatory subunit of the 26S proteasomelid, similar to mammalian p55 subunit and toanother S. cerevisiae regulatory subunit, Rpn7p 0.003090.05256 S000000690CDC50YCR094WverifiedEndosomal protein that regulates cell polarity; similar toYnr048wp and Lem3p 0.003090.05256&radic&radic&radic&radic S000005732NOC2YOR206WverifiedProtein that forms a nucleolar complex with Mak21p that bindsto 90S and 66S pre-ribosomes, as well as anuclear complex with Noc3p that binds to 66Spre-ribosomes; both complexes mediateintranuclear transport of ribosomal precursors 0.003060.05211&radic S000005469ZEO1YOL109WverifiedPeripheral membrane protein of the plasma membrane thatinteracts with Mid2p; regulates the cellintegrity pathway mediated by Pkc1p and Slt2p 0.003060.05211 S000005533SGT2YOR007CverifiedGlutamine-rich cytoplasmic protein of unknown function;contains tetratricopeptide (TPR) repeats, whichoften mediate protein-protein interactions; hassimilarity to human SGT, which is a cochaperonethat negatively regulates Hsp70 0.003070.05211&radic&radic S000005676MRPL23YOR150WverifiedMitochondrial ribosomal protein of the large subunit 0.003060.05211&radic S000001153UBA4YHR111WverifiedProtein that activates Urm1p before its conjugation to proteins(urmylation); one target is the thioredoxinperoxidase Ahp1p, suggesting a role ofurmylation in the oxidative stress response 0.003070.05211&radic&radic&radic S000001715MEH1YKR007WverifiedComponent of the EGO complex, which is involved in theregulation of microautophagy, and of the GSEcomplex, which is required for proper sortingof amino acid permease Gap1p; loss results in adefect in vacuolar acidification 0.003080.05211&radic&radic&radic&radic S000006376YPR172WUncharacterizedProtein of unknown function, transcriptionally activated by Yrm1p along with genes involved in multidrug resistance 0.003070.05211&radic&radic S000002251PMT5YDL093WverifiedProtein O-mannosyltransferase, transfers mannose residues fromdolichyl phosphate-D-mannose to proteinserine/threonine residues; acts in a complexwith Pmt3p, can instead interact with Pmt2p insome conditions; target for new antifungals 0.003080.05211&radic&radic S000002744YDR336WUncharacterizedPutative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene 0.003070.05211&radic S000005294PRP2YNR011CverifiedRNA-dependent ATPase in the DEAH-box family, required foractivation of the spliceosome before the firsttransesterification step in RNA splicing 0.003070.05211&radic S000003464NAS6YGR232WverifiedRegulatory, non-ATPase subunit of the 26S proteasome; homologof the human oncoprotein gankyrin, whichinteracts with the retinoblastoma tumorsuppressor (Rb) and cyclin-dependent kinase 4/6 0.003060.05203&radic&radic S000002490RRP8YDR083WverifiedNucleolar protein involved in rRNA processing, pre-rRNAcleavage at site A2; also involved in telomeremaintenance; mutation is synthetically lethalwith a gar1 mutation 0.003050.052&radic&radic S000004008POM34YLR018CverifiedIntegral membrane protein of the nuclear pore; has an importantrole in maintaining the architecture of thepore complex 0.003040.05187&radic&radic S000001776BET3YKR068CverifiedHydrophilic protein that acts in conjunction with SNAREproteins in targeting and fusion of ER to Golgitransport vesicles; component of the TRAPP(transport protein particle) complex 0.003040.05187&radic S000003859YJR098CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; detectable in highly purified mitochondria 0.003040.05187&radic S000001680PEX1YKL197CverifiedAAA-family ATPase peroxin required for peroxisome biogenesis,contains two 230 amino acid ATP-binding AAAcassettes, upregulated in anaerobiosis; Pex1pand Pex6p interact via their N-terminalAAA-cassettes 0.003040.05187&radic S000001924CDC14YFR028CverifiedProtein phosphatase required for mitotic exit; located in thenucleolus until liberated by the FEAR andMitotic Exit Network in anaphase, enabling itto act on key substrates to effect a decreasein CDK/B-cyclin activity and mitotic exit 0.003050.05187 S000002189DBP10YDL031WverifiedPutative ATP-dependent RNA helicase of the DEAD-box proteinfamily, constituent of 66S pre-ribosomalparticles; essential protein involved inribosome biogenesis 0.003030.05175 S000003289LST7YGR057CverifiedProtein possibly involved in a post-Golgi secretory pathway;required for the transport ofnitrogen-regulated amino acid permease Gap1pfrom the Golgi to the cell surface 0.003020.05162&radic&radic&radic&radic S000001314RPL34BYIL052CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl34Ap and has similarity to ratL34 ribosomal protein 0.003030.05162&radic&radic&radic S000002347PPH22YDL188CverifiedCatalytic subunit of protein phosphatase 2A, functionallyredundant with Pph21p; methylated at Cterminus; forms alternate complexes withseveral regulatory subunits; involved in signaltransduction and regulation of mitosis 0.003020.05162&radic S000001285YKE4YIL023CverifiedZinc transporter; localizes to the ER; null mutant is sensitiveto calcofluor white, leads to zinc accumulationin cytosol; ortholog of the mouse KE4 andmember of the ZIP (ZRT, IRT-like Protein)family 0.003010.05143&radic&radic S000005966VPS16YPL045WverifiedSubunit of the homotypic vacuole fusion and vacuole proteinsorting (HOPS) complex; part of the Class C Vpscomplex essential for membrane docking andfusion at both the Golgi-to-endosome andendosome-to-vacuole stages of protein transport 0.003020.05143&radic&radic&radic&radic&radic S000001284TIM44YIL022WverifiedPeripheral mitochondrial membrane protein involved inmitochondrial protein import, tethers essentialchaperone Ssc1p to the translocon channel atthe matrix side of the inner membrane 0.0030.05122&radic&radic S000004903HAS1YMR290CverifiedATP-dependent RNA helicase; localizes to both the nuclearperiphery and nucleolus; highly enriched innuclear pore complex fractions; constituent of66S pre-ribosomal particles 0.003010.05122&radic S000000656TAH1YCR060WverifiedHSP90 cofactor; interacts with Hsp82p, Pih1p, Rvb1 and Rvb2,contains a single TPR domain with at least twoTPR motifs 0.0030.05122&radic S000003628HPR5YJL092WverifiedDNA helicase and DNA-dependent ATPase involved in DNA repair,required for proper timing of commitment tomeiotic recombination and the transition fromMeiosis I to Meiosis II; potential Cdc28psubstrate 0.003010.05122 S000005055CYB5YNL111CverifiedCytochrome b5, involved in the sterol and lipid biosynthesispathways; required for sterol C5-6 and fattyacid desaturation 0.0030.05122&radic S000006127YPL206CUncharacterizedProtein that plays a role in metabolism of glycerophosphocholine to phosphatidylcholine; contains glycerophosphodiester phosphodiesterase motifs 0.003010.05122&radic&radic S000004141PCD1YLR151CverifiedPeroxisomal nudix pyrophosphatase with specificity for coenzymeA and CoA derivatives, may function to removepotentially toxic oxidized CoA disulfide fromperoxisomes to maintain the capacity forbeta-oxidation of fatty acids 0.0030.05122&radic S000004893CAT8YMR280CverifiedZinc cluster transcriptional activator necessary forderepression of a variety of genes undernon-fermentative growth conditions, activeafter diauxic shift, binds carbon sourceresponsive elements 0.0030.05122&radic&radic S000007524YMR122W-AUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum 0.002990.051&radic S000002345YDL186WUncharacterizedHypothetical protein 0.002990.051 S000000029GIP4YAL031CverifiedCytoplasmic Glc7-interacting protein whose overexpressionrelocalizes Glc7p from the nucleus and preventschromosome segregation; potential Cdc28psubstrate 0.002990.051&radic S000001587GFA1YKL104CverifiedGlutamine-fructose-6-phosphate amidotransferase, catalyzes theformation of glucosamine-6-P and glutamate fromfructose-6-P and glutamine in the first step ofchitin biosynthesis 0.002980.0508&radic S000005133SRP1YNL189WverifiedKaryopherin alpha homolog, forms a dimer with karyopherin betaKap95p to mediate import of nuclear proteins,binds the nuclear localization signal of thesubstrate during import; may also play a rolein regulation of protein degradation 0.002980.0508&radic S000003382YGR150CUncharacterizedPutative protein of unknown function; deletion mutant has growth defects on both non-fermentable carbon sources and rich medium; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; contains PPR motifs 0.002980.0508&radic S000003963VPS13YLL040CverifiedProtein of unknown function; heterooligomeric or homooligomericcomplex; peripherally associated withmembranes; homologous to human COH1; involvedin sporulation, vacuolar protein sorting andprotein-Golgi retention 0.002970.0508&radic&radic&radic S000004213IFH1YLR223CverifiedEssential protein with a highly acidic N-terminal domain; IFH1exhibits genetic interactions with FHL1,overexpression interferes with silencing attelomeres and HM loci; potential Cdc28psubstrate 0.002960.05065&radic S000005034RHO2YNL090WverifiedNon-essential small GTPase of the Rho/Rac subfamily of Ras-likeproteins, involved in the establishment of cellpolarity and in microtubule assembly 0.002960.05065&radic S000001953YFR057WUncharacterizedHypothetical protein 0.002970.05065&radic S000005365RPB11YOL005CverifiedRNA polymerase II subunit B12.5; part of central core; similarto Rpc19p and bacterial alpha subunit 0.002960.05065 S000001578YJU2YKL095WverifiedEssential nuclear protein; putative spliceosomal componentinvolved in mRNA splicing, based oncomputational analysis of large-scaleprotein-protein interaction data 0.002960.0506&radic&radic S000002457TPI1YDR050CverifiedTriose phosphate isomerase, abundant glycolytic enzyme; mRNAhalf-life is regulated by iron availability;transcription is controlled by activatorsReb1p, Gcr1p, and Rap1p through binding sitesin the 5' non-coding region 0.002960.0506&radic&radic S000000110RRN6YBL014CverifiedProtein involved in the transcription of 35S rRNA genes by RNApolymerase I; component of the core factor (CF)complex also composed of Rrn11p, Rrn7p andTATA-binding protein 0.002950.0505&radic&radic&radic S000000465YBR261CUncharacterizedPutative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBR261C is not an essential gene 0.002950.05034&radic S000004801GCV2YMR189WverifiedP subunit of the mitochondrial glycine decarboxylase complex,required for the catabolism of glycine to5,10-methylene-THF; expression is regulated bylevels of levels of 5,10-methylene-THF in thecytoplasm 0.002940.05034&radic S000006386SMX3YPR182WverifiedCore Sm protein Sm F; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm F 0.002940.05034&radic&radic S000001323SNP1YIL061CverifiedComponent of U1 snRNP required for mRNA splicing viaspliceosome; may interact with poly(A)polymerase to regulate polyadenylation; homologof human U1 70K protein 0.002940.05034&radic S000001485DID4YKL002WverifiedClass E Vps protein of the ESCRT-III complex, required forsorting of integral membrane proteins intolumenal vesicles of multivesicular bodies, andfor delivery of newly synthesized vacuolarenzymes to the vacuole, involved in endocytosis 0.002940.05002&radic&radic&radic&radic S000005066YNL122CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene 0.002920.05002&radic S000002341LYS20YDL182WverifiedHomocitrate synthase isozyme, catalyzes the condensation ofacetyl-CoA and alpha-ketoglutarate to formhomocitrate, which is the first step in thelysine biosynthesis pathway; highly similar tothe other isozyme, Lys21p 0.002940.05002 S000003861YJR100CUncharacterizedPutative protein of unknown function; appears related to murine NOR1, which is highly expressed in leukemogenic cell lines 0.002920.05002 S000005844FAA1YOR317WverifiedLong chain fatty acyl-CoA synthetase with a preference forC12:0-C16:0 fatty acids; involved in theactivation of imported fatty acids; localizedto both lipid particles and mitochondrial outermembrane; essential for stationary phase 0.002940.05002 S000006230ATH1YPR026WverifiedAcid trehalase required for utilization of extracellulartrehalose 0.002940.05002 S000001541TOA2YKL058WverifiedTFIIA small subunit; involved in transcriptional activation,acts as antirepressor or as coactivator;homologous to smallest subunit of human andDrosophila TFIIA 0.002930.05002&radic S000004335GAS2YLR343WuncharacterizedPutative 1,3-beta-glucanosyltransferase, has similarity toGas1p 0.002930.05002&radic S000004714ILV2YMR108WverifiedAcetolactate synthase, catalyses the first common step inisoleucine and valine biosynthesis and is thetarget of several classes of inhibitors,localizes to the mitochondria; expression ofthe gene is under general amino acid control 0.002920.05002 S000004688ADH3YMR083WverifiedMitochondrial alcohol dehydrogenase isozyme III; involved inthe shuttling of mitochondrial NADH to thecytosol under anaerobic conditions and ethanolproduction 0.002940.05002 S000000738UBC8YEL012WverifiedUbiquitin-conjugating enzyme that negatively regulatesgluconeogenesis by mediating theglucose-induced ubiquitination offructose-1,6-bisphosphatase (FBPase);cytoplasmic enzyme that catalyzes theubiquitination of histones in vitro 0.002920.05002&radic S000006360TPO3YPR156CverifiedPolyamine transport protein specific for spermine; localizes tothe plasma membrane; member of the majorfacilitator superfamily 0.002910.04975&radic S000000364CDC28YBR160WverifiedCatalytic subunit of the main cell cycle cyclin-dependentkinase (CDK); alternately associates with G1cyclins (CLNs) and G2/M cyclins (CLBs) whichdirect the CDK to specific substrates 0.00290.04975&radic S000003896MCM22YJR135CverifiedProtein involved in minichromosome maintenance; component ofthe kinetochore; binds to centromeric DNA in aCtf19p-dependent manner 0.002920.04975 S000001333PCI8YIL071CverifiedPossible shared subunit of Cop9 signalosome (CSN) and eIF3,binds eIF3b subunit Prt1p, has possible dualfunctions in transcriptional and translationalcontrol, contains a PCI (Proteasome-COP9signalosome (CSN)-eIF3) domain 0.002910.04975&radic&radic&radic&radic S000006295YPR091CUncharacterizedHypothetical protein 0.002910.04975&radic S000003119NUT1YGL151WverifiedComponent of the RNA polymerase II mediator complex, which isrequired for transcriptional activation andalso has a role in basal transcription 0.002890.04957 S000002874PKH3YDR466WverifiedProtein kinase with similarity to mammalianphosphoinositide-dependent kinase 1 (PDK1) andyeast Pkh1p and Pkh2p, two redundant upstreamactivators of Pkc1p; identified as a multicopysuppressor of a pkh1 pkh2 double mutant 0.002890.04957 S000001889SEC4YFL005WverifiedSecretory vesicle-associated Rab GTPase essential forexocytosis; associates with the exocystcomponent Sec15p and may regulate polarizeddelivery of transport vesicles to the exocystat the plasma membrane 0.002880.04945 S000006278TKL1YPR074CverifiedTransketolase, similar to Tkl2p; catalyzes conversion ofxylulose-5-phosphate and ribose-5-phosphate tosedoheptulose-7-phosphate andglyceraldehyde-3-phosphate in the pentosephosphate pathway; needed for synthesis ofaromatic amino acids 0.002880.04938&radic S000004914DYN3YMR299CverifiedDynein light intermediate chain (LIC); localizes with dynein,null mutant is defective in nuclear migration 0.002880.04938&radic&radic S000002160NHP10YDL002CverifiedProtein related to mammalian high mobility group proteins;likely component of the INO80 complex, which isan ATP-dependent chromatin-remodeling complex 0.002880.04938 S000003473YAP1802YGR241CverifiedProtein involved in clathrin cage assembly; binds Pan1p andclathrin; homologous to Yap1801p, member of theAP180 protein family 0.002880.04922&radic&radic S000003085YGL117WUncharacterizedPutative protein of unknown function 0.002870.04922&radic S000005862ALA1YOR335CverifiedCytoplasmic alanyl-tRNA synthetase, required for proteinsynthesis; point mutation (cdc64-1 allele)causes cell cycle arrest at G1; lethality ofnull mutation is functionally complemented byhuman homolog 0.002860.04864&radic&radic S000000507RER1YCL001WverifiedProtein involved in retention of membrane proteins, includingSec12p, in the ER; localized to Golgi;functions as a retrieval receptor in returningmembrane proteins to the ER 0.002860.04864&radic S000005141WHI3YNL197CverifiedRNA binding protein that sequesters CLN3 mRNA in cytoplasmicfoci; cytoplasmic retention factor for Cdc28pand associated cyclins; regulates cell fate anddose-dependently regulates the critical cellsize required for passage through Start 0.002840.04864&radic&radic&radic&radic S000004589NDI1YML120CverifiedNADH:ubiquinone oxidoreductase, transfers electrons from NADHto ubiquinone in the respiratory chain but doesnot pump protons, in contrast to the highereukaryotic multisubunit respiratory complex I;homolog of human AMID 0.002840.04864 S000001271FAA3YIL009WverifiedLong chain fatty acyl-CoA synthetase, has a preference for C16and C18 fatty acids; green fluorescent protein(GFP)-fusion protein localizes to the cellperiphery 0.002850.04864 S000006385SEC23YPR181CverifiedGTPase-activating protein; component of the Sec23p-Sec24pheterodimeric complex of the COPII vesiclecoat, involved in ER to Golgi transport andautophagy; stimulates the GDP-bound form ofSar1p 0.002860.04864&radic S000002665SET7YDR257CverifiedNuclear protein that contains a SET-domain, which have beenshown to mediate methyltransferase activity inother proteins 0.002830.04864 S000002384SHS1YDL225WverifiedOne of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p,Shs1p) that form a cortical filamentous collarat the mother-bud neck which is necessary fornormal morphogenesis and cytokinesis 0.002870.04864 S000001411MLP2YIL149CverifiedMyosin-like protein associated with the nuclear envelope,connects the nuclear pore complex with thenuclear interior; involved in the Tel1p pathwaythat controls telomere length 0.002860.04864 S000000798RMD6YEL072WverifiedProtein required for sporulation 0.002830.04857&radic S000005713TUF1YOR187WverifiedMitochondrial translation elongation factor Tu; comprises bothGTPase and guanine nucleotide exchange factoractivities, while these activities are found inseparate proteins in S. pombe and humans 0.002830.04857 S000000662RAD18YCR066WverifiedProtein involved in postreplication repair; bindssingle-stranded DNA and has single-stranded DNAdependent ATPase activity; forms heterodimerwith Rad6p; contains RING-finger motif 0.002830.04857 S000000375SEC66YBR171WverifiedNon-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66pand Sec72p); with Sec61 complex, Kar2p/BiP andLhs1p forms a channel competent forSRP-dependent and post-translationalSRP-independent protein targeting and importinto the ER 0.002820.04843&radic&radic S000003776YJR015WUncharacterizedPutative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene 0.002820.04843&radic S000002722RAD34YDR314CverifiedProtein involved in nucleotide excision repair (NER);homologous to RAD4 0.002820.04843&radic&radic S000006323CLB2YPR119WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the transition from G2 to Mphase; accumulates during G2 and M, thentargeted via a destruction box motif forubiquitin-mediated degradation by theproteasome 0.00280.04821&radic S000005200FOL1YNL256WverifiedMultifunctional enzyme of the folic acid biosynthesis pathway,has dihydropteroate synthetase,dihydro-6-hydroxymethylpterinpyrophosphokinase, and dihydroneopterinaldolase activities 0.00280.04821&radic&radic S000003325YGR093WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus 0.00280.04821 S000006271ISA2YPR067WverifiedProtein required for maturation of mitochondrial and cytosolicFe/S proteins, localizes to the mitochondrialintermembrane space, overexpression of ISA2suppresses grx5 mutations 0.002810.04821 S000003475FMP43YGR243WuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.00280.0482&radic&radic S000004214YLR224WUncharacterizedF-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene 0.002790.04779 S000005201SIP3YNL257CverifiedProtein that activates transcription through interaction withDNA-bound Snf1p, C-terminal region has aputative leucine zipper motif; potential Cdc28psubstrate 0.002790.04779&radic&radic&radic S000003538PRE3YJL001Wverified20S proteasome beta-type subunit, responsible for cleavageafter acidic residues in peptides 0.002770.04779 S000004437YLR445WUncharacterizedHypothetical protein 0.002770.04779 S000000559SPB1YCL054WverifiedAdoMet-dependent methyltransferase involved in rRNA processingand 60S ribosomal subunit maturation;methylates G2922 in the tRNA docking site ofthe large subunit rRNA and in the absence ofsnR52, U2921; suppressor of PAB1 mutants 0.002790.04779&radic&radic&radic S000001374HOS4YIL112WuncharacterizedSubunit of the Set3 complex, which is a meiotic-specificrepressor of sporulation specific genes thatcontains deacetylase activity; potential Cdc28psubstrate 0.002780.04779 S000000433ROT2YBR229CverifiedGlucosidase II catalytic subunit required for normal cell wallsynthesis; mutations in rot2 suppress tor2mutations, and are synthetically lethal withrot1 mutations 0.002780.04779&radic&radic&radic S000004536COG8YML071CverifiedComponent of the conserved oligomeric Golgi complex (Cog1pthrough Cog8p), a cytosolic tethering complexthat functions in protein trafficking tomediate fusion of transport vesicles to Golgicompartments 0.002770.04779&radic S000004598COX14YML129CverifiedMitochondrial membrane protein, required for assembly ofcytochrome c oxidase 0.002790.04779 S000006114RSA1YPL193WverifiedProtein involved in the assembly of 60S ribosomal subunits;functionally interacts with Dbp6p; functions ina late nucleoplasmic step of the assembly 0.002790.04779&radic&radic&radic&radic S000000359CNS1YBR155WverifiedTPR-containing co-chaperone; binds both Hsp82p (Hsp90) andSsa1p (Hsp70) and stimulates the ATPaseactivity of SSA1, ts mutants reduce Hsp82pfunction while over expression suppresses thephenotypes of an HSP82 ts allele and a cpr7deletion 0.002780.04779&radic S000002892VPS52YDR484WverifiedComponent of the GARP (Golgi-associated retrograde protein)complex, Vps51p-Vps52p-Vps53p-Vps54p, which isrequired for the recycling of proteins fromendosomes to the late Golgi; involved inlocalization of actin and chitin 0.002760.04763&radic&radic&radic S000003306SMD1YGR074WverifiedCore Sm protein Sm D1; part of heteroheptameric complex (withSmb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D1 0.002760.04763&radic&radic S000005562PEP12YOR036WverifiedTarget membrane receptor (t-SNARE) for vesicular intermediatestraveling between the Golgi apparatus and thevacuole; controls entry of biosynthetic,endocytic, and retrograde traffic into theprevacuolar compartment; syntaxin 0.002760.04763&radic&radic&radic S000002441LYS14YDR034CverifiedTranscriptional activator involved in regulation of genes ofthe lysine biosynthesis pathway; requires2-aminoadipate semialdehyde as co-inducer 0.002770.04763&radic S000000959COG3YER157WverifiedEssential component of the conserved oligomeric Golgi complex(Cog1p through Cog8p), a cytosolic tetheringcomplex that functions in protein traffickingto mediate fusion of transport vesicles toGolgi compartments 0.002760.04762 S000000773YEL047CVerifiedFumurate ReDuctase Soluble 0.002750.04734&radic&radic S000006229CCL1YPR025CverifiedCyclin associated with protein kinase Kin28p, which is theTFIIH-associated carboxy-terminal domain (CTD)kinase involved in transcription initiation atRNA polymerase II promoters 0.002740.04734 S000003633PHS1YJL097WuncharacterizedProtein of unknown function; homolog of mammalian PTPLA;involved in sphingolipid biosynthesis, proteintrafficking; required for cell viability 0.002750.04734 S000005798YTM1YOR272WverifiedConstituent of 66S pre-ribosomal particles, required formaturation of the large ribosomal subunit 0.002740.04734 S000001494CCE1YKL011CverifiedMitochondrial cruciform cutting endonuclease, cleaves Hollidayjunctions formed during recombination ofmitochondrial DNA 0.002750.04734&radic S000003087ABC1YGL119WverifiedProtein required for ubiquinone (coenzyme Q) biosynthesis andfor respiratory growth; exhibits geneticinteraction with COQ9, suggesting a commonfunction; similar to prokaryotic proteinsinvolved in early steps of ubiquinonebiosynthesis 0.002750.04734 S000006383HDA3YPR179CverifiedSubunit of a possibly tetrameric trichostatin A-sensitive classII histone deacetylase complex that contains anHda1p homodimer and an Hda2p-Hda3p heterodimer;required for the activity of the complex; hassimilarity to Hda2p 0.002730.04697&radic&radic S000000259PRP6YBR055CverifiedSplicing factor, component of the U4/U6-U5 snRNP complex 0.002730.04697&radic S000006405ARR3YPR201WverifiedArsenite transporter of the plasma membrane, required forresistance to arsenic compounds; transcriptionis activated by Arr1p in the presence ofarsenite 0.002730.04697&radic&radic&radic S000005322ZRG17YNR039CverifiedEndoplasmic reticulum protein of unknown function,transcription is induced under conditions ofzinc deficiency; mutant phenotype suggests arole in uptake of zinc 0.002720.04697 S000003279TFC4YGR047CverifiedOne of six subunits of the RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part of theTauA domain of TFIIIC that binds BoxA DNApromoter sites of tRNA and similar genes; hasTPR motifs; human homolog is TFIIIC-102 0.002710.04697&radic&radic&radic S000005553STI1YOR027WverifiedHsp90 cochaperone, interacts with the Ssa group of thecytosolic Hsp70 chaperones; activates theATPase activity of Ssa1p; homolog of mammalianHop protein 0.002730.04697&radic&radic&radic S000002385GCS1YDL226CverifiedADP-ribosylation factor GTPase activating protein (ARF GAP),involved in ER-Golgi transport; sharesfunctional similarity with Glo3p 0.002730.04697&radic&radic S000005607TGL5YOR081CverifiedTriacylglycerol lipase involved in TAG mobilization; localizesto lipid particles; potential Cdc28p substrate 0.002710.04697&radic&radic S000005366TOP1YOL006CverifiedTopoisomerase I, nuclear enzyme that relieves torsional strainin DNA by cleaving and re-sealing thephosphodiester backbone; relaxes bothpositively and negatively supercoiled DNA;functions in replication, transcription, andrecombination 0.002710.04697&radic S000005507PEX11YOL147CverifiedPeroxisomal membrane protein required for peroxisomeproliferation and medium-chain fatty acidoxidation, most abundant protein in theperoxisomal membrane, regulated by Adr1p andPip2p-Oaf1p, promoter contains ORE andUAS1-like elements 0.002720.04697 S000003057MF(ALPHA)2YGL089CverifiedMating pheromone alpha-factor, made by alpha cells; interactswith mating type a cells to induce cell cyclearrest and other responses leading to mating;also encoded by MF(ALPHA)1, which is morehighly expressed than MF(ALPHA)2 0.002710.04697&radic S000003543CTK2YJL006CverifiedBeta subunit of C-terminal domain kinase I (CTDK-I), whichphosphorylates the C-terminal repeated domainof the RNA polymerase II large subunit (Rpo21p)to affect both transcription and pre-mRNA 3'end processing; has similarity to cyclins 0.002720.04697 S000001618APL2YKL135CverifiedBeta-adaptin, large subunit of the clathrin-associated protein(AP-1) complex; binds clathrin; involved inclathrin-dependent Golgi protein sorting 0.002720.04697&radic&radic S000005952PHO85YPL031CverifiedCyclin-dependent kinase, with ten cyclin partners; involved inenvironmental stress response; inphosphate-rich conditions, Pho85p-Pho80pcomplex phosphorylates Pho4p which in turnrepresses PHO5 0.002710.04685&radic&radic&radic&radic&radic S000004846YMR233WUncharacterizedProtein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; YMR233W is not an essential gene 0.00270.04685&radic&radic&radic&radic S000000440ABD1YBR236CverifiedMethyltransferase, catalyzes the transfer of a methyl groupfrom S-adenosylmethionine to the GpppN terminusof capped mRNA 0.002710.04685&radic&radic S000004588YML119WUncharacterizedPutative protein of unknown funtion; YML119W is not an essential gene; potential Cdc28p substrate 0.002690.04657 S000005206POL2YNL262WverifiedCatalytic subunit of DNA polymerase epsilon, one of the majorchromosomal DNA replication polymerasescharacterized by processivity and proofreadingexonuclease activity; also involved in DNAsynthesis during DNA repair 0.00270.04657&radic&radic&radic S000005354YNR071CUncharacterizedHypothetical protein 0.00270.04657 S000005506PSF3YOL146WverifiedSubunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), whichis localized to DNA replication origins andimplicated in assembly of the DNA replicationmachinery 0.00270.04657 S000000958YER156CUncharacterizedHypothetical protein 0.002680.04657&radic S000002721PIB1YDR313CverifiedRING-type ubiquitin ligase of the endosomal and vacuolarmembranes, bindsphosphatidylinositol(3)-phosphate; contains aFYVE finger domain 0.002680.04657 S000004834FMP42YMR221CuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.002680.04657 S000001371SEC24YIL109CverifiedComponent of the Sec23p-Sec24p heterodimeric complex of theCOPII vesicle coat; involved in ER to Golgitransport, cargo selection and autophagy;required for the binding of the Sec13 complexto ER membranes; homologous to Lst1p and Lss1p 0.00270.04657 S000003903YJR142WUncharacterizedPutative protein of unknown function 0.002690.04657&radic S000005863KRE5YOR336WverifiedProtein required for beta-1,6 glucan biosynthesis; mutationsresult in aberrant morphology and severe growthdefects 0.002680.04617 S000003052GUP1YGL084CverifiedPlasma membrane protein with a possible role in proton symportof glycerol; member of the MBOAT family ofputative membrane-bound O-acyltransferases 0.002660.04617&radic S000005059YNL115CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene 0.002650.04617&radic S000005355HXT17YNR072WverifiedHexose transporter, up-regulated in media containing raffinoseand galactose at pH 7.7 versus pH 4.7,repressed by high levels of glucose 0.002660.04617 S000001870EPL1YFL024CverifiedComponent of NuA4, which is an essential histone H4/H2Aacetyltransferase complex; homologous toDrosophila Enhancer of Polycomb 0.002650.04617 S000003200YGL231CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum 0.002670.04617&radic S000000683YCR087WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene 0.002650.04615&radic S000007255TIM11YDR322C-AverifiedSubunit e of mitochondrial F1F0-ATPase, which is a large,evolutionarily conserved enzyme complexrequired for ATP synthesis; essential for thedimeric state of ATP synthase 0.002650.04609 S000002940YDR532CUncharacterizedProtein of unknown function that localizes to the nuclear side of the spindle pole body and along short spindles; deletion mutants have short telomeres; forms a complex with Spc105p 0.002640.04609&radic&radic S000002100VMA10YHR039C-AverifiedVacuolar H+ ATPase subunit G of the catalytic (V1) sector,involved in vacuolar acidification 0.002650.04609&radic&radic S000005113PSD1YNL169CverifiedPhosphatidylserine decarboxylase of the mitochondrial innermembrane, converts phosphatidylserine tophosphatidylethanolamine 0.002640.04604&radic S000001305CBR1YIL043CverifiedMicrosomal cytochrome b reductase, not essential for viability;also detected in mitochondria; mutation inconserved NADH binding domain of the humanortholog results in type I methemoglobinemia 0.002630.04595&radic&radic S000002973COG7YGL005CverifiedComponent of the conserved oligomeric Golgi complex (Cog1pthrough Cog8p), a cytosolic tethering complexthat functions in protein trafficking tomediate fusion of transport vesicles to Golgicompartments 0.002640.04595&radic&radic S000005323YNR040WUncharacterizedHypothetical protein 0.002630.04595 S000000490APE3YBR286WverifiedVacuolar aminopeptidase Y, processed to mature form by Prb1p 0.002630.04594&radic S000001957SAE3YHR079C-AverifiedMeiosis specific protein involved in DMC1-dependent meioticrecombination, forms heterodimer with Mei5p;proposed to be an assembly factor for Dmc1p 0.002630.04584 S000005057RPC19YNL113WverifiedRNA polymerase subunit, common to RNA polymerases I and III 0.002620.04584&radic S000002568YDR161WUncharacterizedinteracts with PP2C 0.002620.04584&radic&radic S000001812YKR104WVerifiedPutative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds 0.002620.04584 S000001629AVT3YKL146WverifiedVacuolar transporter, exports large neutral amino acids fromthe vacuole; member of a family of seven S.cerevisiae genes (AVT1-7) related to vesicularGABA-glycine transporters 0.002620.04584 S000001542MPE1YKL059CverifiedEssential conserved subunit of CPF (cleavage andpolyadenylation factor), plays a role in 3' endformation of mRNA via the specific cleavage andpolyadenylation of pre-mRNA, contains aputative RNA-binding zinc knuckle motif 0.002620.04578&radic S000001040COS8YHL048WverifiedNuclear membrane protein, member of the DUP380 subfamily ofconserved, often subtelomerically-encodedproteins; regulation suggests a potential rolein the unfolded protein response 0.002620.04578 S000000178ALG3YBL082CverifiedDolichol-P-Man dependent alpha(1-3) mannosyltransferase,involved in the synthesis of dolichol-linkedoligosaccharide donor for N-linkedglycosylation of proteins 0.00260.04544&radic S000003416UBR1YGR184CverifiedUbiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2pto ubiquitinate substrates of the N-end rulepathway; binds to the Rpn2p, Rpt1p, and Rpt6pproteins of the 19S particle of the 26Sproteasome 0.00260.04544 S000005527RRP6YOR001WverifiedExonuclease component of the nuclear exosome; contributes tothe quality-control system that retains anddegrades aberrant mRNAs in the nucleus 0.002610.04544&radic&radic S000000109FMT1YBL013WverifiedMethionyl-tRNA formyltransferase, catalyzes the formylation ofinitiator Met-tRNA in mitochondria; potentialCdc28p substrate 0.002610.04544&radic S000003397MRPS35YGR165WverifiedMitochondrial ribosomal protein of the small subunit 0.002590.04535&radic S000005846HSH49YOR319WverifiedU2-snRNP associated splicing factor with similarity to themammalian splicing factor SAP49; proposed tofunction as a U2-snRNP assembly factor alongwith Hsh155p and binding partner Cus1p;contains two RNA recognition motifs (RRM) 0.002590.04535&radic S000003332MDR1YGR100WverifiedCytoplasmic GTPase-activating protein for Ypt/Rab transportGTPases Ypt6p, Ypt31p and Sec4p; involved inrecycling of internalized proteins andregulation of Golgi secretory function 0.002590.04535&radic&radic&radic S000003081SLD3YGL113WverifiedProtein involved in the initiation of DNA replication, requiredfor proper assembly of replication proteins atthe origins of replication; interacts withCdc45p 0.002580.04509&radic S000000075UIP3YAR027WverifiedPutative integral membrane protein of unknown function;interacts with Ulp1p at the nuclear periphery;member of DUP240 gene family 0.002580.04509&radic&radic S000001070DAP2YHR028CverifiedDipeptidyl aminopeptidase, synthesized as a glycosylatedprecursor; localizes to the vacuolar membrane;similar to Ste13p 0.002580.04509&radic S000004728RPL15BYMR121CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl15Ap and has similarity to ratL15 ribosomal protein; binds to 5.8 S rRNA 0.002570.04509&radic S000005204YNL260CUncharacterizedPutative protein of unknown function with similarity to a human protein overexpressed in oral cancers; localizes to the nucleus and cytoplasm; YNL260C is an essential gene 0.002590.04509 S000001390MET18YIL128WverifiedDNA repair and TFIIH regulator, required for both nucleotideexcision repair (NER) and RNA polymerase II(RNAP II) transcription; involved in telomeremaintenance 0.002570.04509&radic&radic S000003860YUH1YJR099WverifiedUbiquitin C-terminal hydrolase that cleaves ubiquitin-proteinfusions to generate monomeric ubiquitin;hydrolyzes the peptide bond at the C-terminusof ubiquitin; also the major processing enzymefor the ubiquitin-like protein Rub1p 0.002580.04509 S000005262HXT14YNL318CverifiedProtein with similarity to hexose transporter family members,expression is induced in low glucose andrepressed in high glucose; the authentic,non-tagged protein is detected in highlypurified mitochondria in high-throughputstudies 0.002560.04497&radic S000006272HOS1YPR068CverifiedPutative class I histone deacetylase (HDAC) with sequencesimilarity to Hda1p, Rpd3p, Hos2p, and Hos3p;deletion results in increased histoneacetylation at rDNA repeats; interacts with theTup1p-Ssn6p corepressor complex 0.002560.04497 S000002909PLM2YDR501WverifiedProtein required for partitioning of the 2-micron plasmid 0.002550.04463 S000003088PRP43YGL120CverifiedRNA helicase in the DEAH-box family, functions in both RNApolymerase I and polymerase II transcriptmetabolism, involved in release of thelariat-intron from the spliceosome 0.002550.04463 S000005997GPI2YPL076WverifiedProtein involved in the synthesis of N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI), the firstintermediate in the synthesis ofglycosylphosphatidylinositol (GPI) anchors;homologous to the human PIG-C protein 0.002560.04463&radic S000006384AOS1YPR180WverifiedNuclear protein that acts as a heterodimer with Uba2p toactivate Smt3p (SUMO) before its conjugation toproteins (sumoylation), which may play a rolein protein targeting; essential for viability 0.002540.04463&radic S000002657YDR249CUncharacterizedHypothetical protein 0.002560.04463 S000005675SMP3YOR149CverifiedAlpha 1,2-mannosyltransferase involved in glycosyl phosphatidylinositol (GPI) biosynthesis; required foraddition of the fourth, side branching mannoseto the GPI core structure 0.002520.04439 S000004800MRPS17YMR188CverifiedMitochondrial ribosomal protein of the small subunit 0.002520.04439&radic S000003684RPA34YJL148WverifiedRNA polymerase I subunit A34.5 0.002530.04439&radic S000000028SNC1YAL030WverifiedVesicle membrane receptor protein (v-SNARE) involved in thefusion between Golgi-derived secretory vesicleswith the plasma membrane; proposed to beinvolved in endocytosis; member of thesynaptobrevin/VAMP family of R-type v-SNAREproteins 0.002530.04439&radic S000003806SSC1YJR045CverifiedMitochondrial matrix ATPase that is a subunit of thepresequence translocase-associated proteinimport motor (PAM); involved in proteintranslocation into the matrix and proteinfolding; member of the heat shock protein 70(HSP70) family 0.002520.04422 S000003850GRR1YJR090CverifiedF-box protein component of the SCF ubiquitin-ligase complex,required for Cln1p and Cln2p degradation;involved in carbon catabolite repression,glucose-dependent divalent cation transport,high-affinity glucose transport, andmorphogenesis 0.002520.04422 S000000421ATG12YBR217WverifiedUbiquitin-like modifier, conjugated via an isopeptide bond to alysine residue of Atg5p by the E1 enzyme,Atg7p, and the E2 enzyme, Atg10p, a step thatis essential for autophagy 0.002520.04422&radic&radic S000003694CIS3YJL158CverifiedMannose-containing glycoprotein constituent of the cell wall;member of the PIR (proteins with internalrepeats) family 0.002520.04422 S000002371SHR3YDL212WverifiedEndoplasmic reticulum packaging chaperone, required forincorporation of amino acid permeases intoCOPII coated vesicles for transport to the cellsurface 0.002510.04418 S000005260PHA2YNL316CverifiedPrephenate dehydratase, catalyzes the conversion of prephanateto phenylpyruvate, which is a step in thephenylalanine biosynthesis pathway 0.002510.04418&radic S000005228MRPL10YNL284CverifiedMitochondrial ribosomal protein of the large subunit; appearsas two protein spots (YmL10 and YmL18) ontwo-dimensional SDS gels 0.00250.04402 S000005685SME1YOR159CverifiedCore Sm protein Sm E; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm E 0.00250.04402 S000002565HOM2YDR158WverifiedAspartic beta semi-aldehyde dehydrogenase, catalyzes the secondstep in the common pathway for methionine andthreonine biosynthesis; expression regulated byGcn4p and the general control of amino acidsynthesis 0.00250.04402&radic&radic S000004953ASI3YNL008CverifiedPutative integral membrane E3 ubiquitin ligase; acts with Asi1pand Asi2p to ensure the fidelity of SPS-sensorsignalling by maintaining the dormant repressedstate of gene expression in the absence ofinducing signals 0.00250.04402 S000002493SSS1YDR086CverifiedSubunit of the Sec61p translocation complex(Sec61p-Sss1p-Sbh1p) that forms a channel forpassage of secretory proteins through theendoplasmic reticulum membrane, and of theSsh1p complex (Ssh1p-Sbh2p-Sss1p); interactswith Ost4p and Wbp1p 0.002490.04391&radic S000005402NGL1YOL042WverifiedPutative endonuclease, has a domain similar to amagnesium-dependent endonuclease motif in mRNAdeadenylase Ccr4p; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.002490.04386 S000004643YET2YMR040WverifiedProtein of unknown function that may interact with ribosomes,based on co-purification experiments; homologof human BAP31 protein 0.002480.04376 S000004046ERG3YLR056WverifiedC-5 sterol desaturase, catalyzes the introduction of a C-5(6)double bond into episterol, a precursor inergosterol biosynthesis; mutants are viable,but cannot grow on non-fermentable carbonsources 0.002470.04365&radic&radic&radic S000000441PRP5YBR237WverifiedRNA helicase in the DEAD-box family, necessary forprespliceosome formation, bridges U1 and U2snRNPs and enables stable U2 snRNP associationwith intron RNA 0.002470.04365&radic S000002908RPL37BYDR500CverifiedProtein component of the large (60S) ribosomal subunit, hassimilarity to Rpl37Ap and to rat L37 ribosomalprotein 0.002470.04356&radic S000002257BUG1YDL099WuncharacterizedProtein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to the cytoplasmin a punctate pattern 0.002460.04346 S000005036YNL092WUncharacterizedPutative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene 0.002450.04346 S000003957RIX7YLL034CverifiedPutative ATPase of the AAA family, required for export ofpre-ribosomal large subunits from the nucleus;distributed between the nucleolus, nucleoplasm,and nuclear periphery depending on growthconditions 0.002450.04339&radic S000003193VRG4YGL225WverifiedGolgi GDP-mannose transporter; regulates Golgi function andglycosylation in Golgi 0.002440.04313&radic&radic S000000069BUD14YAR014CverifiedProtein involved in bud-site selection, Bud14p-Glc7p complexfunctions as a cortical regulator of dynein;diploid mutants display a random buddingpattern instead of the wild-type bipolarpattern 0.002450.04313&radic&radic&radic S000002235VAM6YDL077CverifiedVacuolar protein that plays a critical role in the tetheringsteps of vacuolar membrane fusion byfacilitating guanine nucleotide exchange onsmall guanosine triphosphatase Ypt7p 0.002440.04313&radic&radic&radic S000001728VPS51YKR020WverifiedComponent of the GARP (Golgi-associated retrograde protein)complex, Vps51p-Vps52p-Vps53p-Vps54p, which isrequired for the recycling of proteins fromendosomes to the late Golgi; links the(VFT/GARP) complex to the SNARE Tlg1p 0.002420.04281&radic&radic&radic&radic S000003221RTG2YGL252CverifiedSensor of mitochondrial dysfunction; regulates the subcellularlocation of Rtg1p and Rtg3p, transcriptionalactivators of the retrograde (RTG) and TORpathways; Rtg2p is inhibited by thephosphorylated form of Mks1p 0.002410.04281&radic&radic&radic&radic S000004474YML012C-ADubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1 0.002410.04281&radic&radic&radic&radic S000006181YPL260WUncharacterizedHypothetical protein 0.002420.04281&radic&radic&radic&radic S000005232CAF40YNL288WverifiedEvolutionarily conserved subunit of the CCR4-NOT complexinvolved in controlling mRNA initiation,elongation and degradation; binds Cdc39p 0.002420.04281&radic&radic&radic S000003740RCY1YJL204CverifiedF-box protein involved in recycling plasma membrane proteinsinternalized by endocytosis; localized to sitesof polarized growth 0.002410.04252&radic&radic&radic&radic S000004330OPI9YLR338WdubiousDubious open reading frame unlikely to encode a protein, basedon available experimental and comparativesequence data; partially overlaps the verifiedORF VRP1/YLR337C 0.002410.04252&radic&radic&radic&radic S000005263YNL319WDubiousDubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14 0.002370.04208&radic&radic S000002563RPA14YDR156WverifiedRNA polymerase I subunit A14 0.002390.04208&radic&radic S000001121IRE1YHR079CverifiedSerine-threonine kinase and endoribonuclease; transmembraneprotein that initiates the unfolded proteinresponse signal by regulating synthesis ofHac1p through HAC1 mRNA splicing 0.002390.04208&radic&radic S000004476TRM9YML014WverifiedtRNA methyltransferase, catalyzes the esterification ofmodified uridine nucleotides in tRNAs, creating5-methylcarbonylmethyluridine in tRNA(Arg3) and5-methylcarbonylmethyl-2-thiouridine intRNA(Glu); may have a role in stress response 0.002370.04208&radic&radic&radic&radic S000005022NIS1YNL078WverifiedProtein localized in the bud neck at G2/M phase; physicallyinteracts with septins; possibly involved in amitotic signaling network 0.002380.04208 S000004439VMA6YLR447CverifiedSubunit D of the five-subunit V0 integral membrane domain ofvacuolar H+-ATPase (V-ATPase), an electrogenicproton pump found in the endomembrane system;stabilizes VO subunits; required for V1 domainassembly on the vacuolar membrane 0.002370.04208&radic S000001414YIL152WUncharacterizedHypothetical protein 0.002370.04203&radic S000002923SLF1YDR515WverifiedRNA binding protein that associates with polysomes; proposed tobe involved in regulating mRNA translation;involved in the copper-dependent mineralizationof copper sulfide complexes on cell surface incells cultured in copper salts 0.002370.04203&radic S000000979BMH1YER177Wverified14-3-3 protein, major isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others 0.002360.04186&radic&radic S000006404ARR2YPR200CverifiedArsenate reductase required for arsenate resistance; convertsarsenate to arsenite which can then be exportedfrom cells by Arr3p 0.002360.04186&radic&radic S000006046KAP120YPL125WverifiedKaryopherin with a role in the assembly or export of 60Sribosomal subunits 0.002360.04186&radic&radic&radic S000000203YBL107CUncharacterizedHypothetical protein 0.002360.04186&radic S000002173TSC13YDL015CverifiedEnoyl reductase that catalyzes the last step in each cycle ofvery long chain fatty acid elongation,localizes to the ER, highly enriched in astructure marking nuclear-vacuolar junctions,coimmunoprecipitates with elongases Fen1p andSur4p 0.002350.04167 S000002456YDR049WUncharacterizedZinc finger protein; putative transcription factor that may interact with proteins involved in histone acetylation or deacetylation; may be involved in altering acetylation on histone lysines 0.002350.04167&radic&radic&radic S000001504MAK11YKL021CverifiedProtein essential for cell growth and replication of M dsRNAvirus; contains four beta-transducin repeats 0.002350.04167&radic&radic S000004750RPL13BYMR142CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl13Ap; not essential forviability; has similarity to rat L13 ribosomalprotein 0.002350.04167&radic&radic S000002608VPS64YDR200CverifiedCytoplasmic protein required for cytoplasm to vacuole targetingof proteins; forms a complex with Far3p, Far7p,Far10p, and Far11p that is involved inpheromone-induced cell cycle arrest; alsolocalized to the endoplasmic reticulum membrane 0.002350.04167&radic&radic&radic&radic S000004560RAD10YML095CverifiedSingle-stranded DNA endonuclease (with Rad1p), cleavessingle-stranded DNA during nucleotide excisionrepair and double-strand break repair; subunitof Nucleotide Excision Repair Factor 1 (NEF1);homolog of human ERCC1 protein 0.002330.04151&radic S000000789CAN1YEL063CverifiedPlasma membrane arginine permease, requires phosphatidylethanolamine (PE) for localization, exclusivelyassociated with lipid rafts; mutation conferscanavanine resistance 0.002340.04151&radic S000001565RRP14YKL082CuncharacterizedEssential protein, constituent of 66S pre-ribosomal particles;interacts with proteins involved in ribosomalbiogenesis and cell polarity; member of theSURF-6 family 0.002340.04151 S000001410RPL40AYIL148WverifiedFusion protein, identical to Rpl40Bp, that is cleaved to yieldubiquitin and a ribosomal protein of the large(60S) ribosomal subunit with similarity to ratL40; ubiquitin may facilitate assembly of theribosomal protein into ribosomes 0.002340.04151&radic&radic S000001317YIL055CUncharacterizedHypothetical protein 0.002340.04151&radic S000001003PRS3YHL011Cverified5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involvedin nucleotide, histidine, and tryptophanbiosynthesis; one of a five related enzymes,which are active as heteromultimeric complexes 0.002330.04137&radic&radic&radic S000005008YDJ1YNL064CverifiedProtein chaperone involved in regulation of the HSP90 and HSP70functions; involved in protein translocationacross membranes; member of the DnaJ family 0.002330.04137&radic&radic S000005257YNL313CUncharacterizedProtein required for cell viability 0.002330.04137&radic&radic&radic S000000634BUD5YCR038CverifiedGTP/GDP exchange factor for Rsr1p (Bud1p) required for bothaxial and bipolar budding patterns; mutantsexhibit random budding in all cell types 0.002330.04137 S000005173URE2YNL229CverifiedNitrogen catabolite repression regulator that acts byinhibition of GLN3 transcription in goodnitrogen source; altered form of Ure2p creates[URE3] prion 0.002320.04126&radic&radic&radic S000000628BPH1YCR032WverifiedPProtein homologous to human Chediak-Higashi syndrome andmurine Beige proteins, which are implicated indisease syndromes due to defective lysosomaltrafficking; mutant phenotype and geneticinteractions suggest a role in protein sorting 0.002310.04098 S000000157SKT5YBL061CverifiedActivator of Chs3p (chitin synthase III), recruits Chs3p to thebud neck via interaction with Bni4p; hassimilarity to Shc1p, which activates Chs3pduring sporulation 0.002320.04098&radic&radic&radic S000005425MET22YOL064CverifiedBisphosphate-3'-nucleotidase, involved in salt tolerance andmethionine biogenesis; dephosphorylates3'-phosphoadenosine-5'-phosphate and3'-phosphoadenosine-5'-phosphosulfate,intermediates of the sulfate assimilationpathway 0.002310.04098&radic&radic S000006377VPS4YPR173CverifiedAAA-type ATPase required for efficient late endosome to vacuoletransport; catalyzes the release of anendosomal membrane-associated class E VPSprotein complex; regulates cellular sterolmetabolism; cytoplasmic and endosomallocalization 0.002310.04098&radic&radic&radic&radic S000002757YPS7YDR349CverifiedPutative GPI-anchored aspartic protease, located in thecytoplasm and endoplasmic reticulum 0.002310.04098&radic&radic&radic S000004255NEJ1YLR265CverifiedProtein involved in regulation of nonhomologous end joining;repressed by MAT heterozygosity; associateswith Lif1p and regulates its cellulardistribution 0.00230.04077&radic&radic&radic&radic S000005001OCA2YNL056WuncharacterizedPutative protein with similarity to predicted tyrosinephosphatases Oca1p and Siw14p; greenfluorescent protein (GFP)-fusion proteinlocalizes to the cytoplasm; YNL056W is not anessential gene 0.002290.04064&radic&radic&radic S000001442YIR003WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with Sac1p to the actin cytoskeleton; interacts with the SH3 domain of the actin binding protein Abp1p; YIR003W is a non-essential gene 0.002290.04064 S000005202DSL1YNL258CverifiedEndoplasmic reticulum (ER)-localized peripheral membraneprotein required for Golgi-to-ER retrogradetraffic; component of the ER target site thatinteracts with coatomer, the major component ofthe COPI vesicle protein coat 0.002280.04064&radic&radic S000002797SAC7YDR389WverifiedGTPase activating protein (GAP) for Rho1p, involved insignaling to the actin cytoskeleton, nullmutations suppress tor2 mutations andtemperature sensitive mutations in actin;potential Cdc28p substrate 0.002290.04064&radic&radic&radic S000001391TAO3YIL129CverifiedProtein involved in cell morphogenesis and proliferation,associated with protein kinase Cbk1p; mutantsactivate OCH1 transcription 0.002280.04057&radic S000003851JSN1YJR091CverifiedMember of the Puf family of RNA-binding proteins, interactswith mRNAs encoding membrane-associatedproteins; overexpression suppresses a tub2-150mutation and causes increased sensitivity tobenomyl in wild-type cells 0.002250.04009 S000002372NOP6YDL213CuncharacterizedProtein with similarity to hydrophilins, which are involved inthe adaptive response to hyperosmoticconditions; computational analysis oflarge-scale protein-protein interaction datasuggests a possible role in rRNA processing 0.002240.0399 S000002319DHH1YDL160CverifiedCytoplasmic DExD/H-box helicase, stimulates mRNA decapping,coordinates distinct steps in mRNA function anddecay, interacts with both the decapping anddeadenylase complexes, may have a role in mRNAexport and translation 0.002240.0399&radic&radic&radic S000000964RAD4YER162CverifiedProtein that recognizes and binds damaged DNA (with Rad23p)during nucleotide excision repair; subunit ofNuclear Excision Repair Factor 2 (NEF2);homolog of human XPC protein 0.002250.0399&radic&radic S000004015SNF7YLR025WverifiedOne of four subunits of the endosomal sorting complex requiredfor transport III (ESCRT-III); involved in thesorting of transmembrane proteins into themultivesicular body (MVB) pathway; recruitedfrom the cytoplasm to endosomal membranes 0.002240.03987&radic&radic&radic S000000330TPS1YBR126CverifiedSynthase subunit of trehalose-6-phosphate synthase/phosphatasecomplex, which synthesizes the storagecarbohydrate trehalose; also found in amonomeric form; expression is induced by thestress response and repressed by the Ras-cAMPpathway 0.002240.03987&radic S000001609YPK1YKL126WverifiedSerine/threonine protein kinase required for receptor-mediatedendocytosis; involved in sphingolipid-mediatedand cell integrity signaling pathways;localized to the bud neck, cytosol and plasmamembrane; homolog of mammalian kinase SGK 0.002230.03944&radic&radic&radic S000000941YER139CUncharacterizedHypothetical protein 0.002230.03944&radic&radic S000001659LST4YKL176CverifiedProtein possibly involved in a post-Golgi secretory pathway;required for the transport ofnitrogen-regulated amino acid permease Gap1pfrom the Golgi to the cell surface 0.002230.03944&radic&radic&radic S000006235NTO1YPR031WuncharacterizedComponent of the histone acetyltransferase complex 0.002230.03944&radic&radic S000002764SPC110YDR356WverifiedInner plaque spindle pole body (SPB) component, ortholog ofhuman kendrin; involved in connecting nuclearmicrotubules to SPB; interacts withTub4p-complex and calmodulin; phosphorylated byMps1p in cell cycle-dependent manner 0.002240.03944&radic&radic S000002743MSN5YDR335WverifiedKaryopherin involved in nuclear import and export; shown to beresponsible for nuclear import of replicationprotein A and for export of several proteinsincluding Swi6p, Far1p, and Pho4p; cargodissociation involves binding to RanGTP 0.002230.03944&radic&radic&radic S000005609WHI5YOR083WverifiedRepressor of G1 transcription that binds to SCB binding factor(SBF) at SCB target promoters in early G1;phosphorylation of Whi5p by the CDK,Cln3p/Cdc28p relieves repression and promoterbinding by Whi5; periodically expressed in G1 0.002240.03944&radic&radic S000005171JJJ1YNL227CverifiedProtein that contains a 70 amino acid J-domain, may function asa co-chaperone to recruit Hsp70-like activityto specific sites; mutation causes defects influid-phase endocytosis 0.002210.03944&radic&radic&radic&radic S000005540RTS1YOR014WverifiedB-type regulatory subunit of protein phosphatase 2A (PP2A);homolog of the mammalian B' subunit of PP2A 0.002230.03944&radic&radic S000003409ATF2YGR177CverifiedAlcohol acetyltransferase, may play a role in steroiddetoxification; forms volatile esters duringfermentation, which is important in brewing 0.002210.03934 S000003308MRPL25YGR076CverifiedMitochondrial ribosomal protein of the large subunit 0.002210.03934&radic&radic S000005605ATX2YOR079CverifiedGolgi membrane protein involved in manganese homeostasis;overproduction suppresses the sod1 (copper,zinc superoxide dismutase) null mutation 0.002210.03934&radic&radic&radic S000002487VPS41YDR080WverifiedVacuolar membrane protein that is a subunit of the homotypicvacuole fusion and vacuole protein sorting(HOPS) complex; essential for membrane dockingand fusion at the Golgi-to-endosome andendosome-to-vacuole stages of protein transport 0.002190.03911&radic&radic&radic S000003878STE24YJR117WverifiedHighly conserved zinc metalloprotease that functions in twosteps of a-factor maturation, C-terminal CAAXproteolysis and the first step of N-terminalproteolytic processing; contains multipletransmembrane spans 0.00220.03911 S000002814PDR15YDR406WverifiedATP binding cassette (ABC) transporter of the plasma membrane;general stress response factor implicated incellular detoxification; target of Pdr1p, Pdr3pand Pdr8p transcription regulators; promotercontains a PDR responsive element 0.002190.03911&radic S000001768UTP30YKR060WuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.00220.03911&radic S000006393SKI3YPR189WverifiedProtein involved in exosome mediated 3' to 5' mRNA degradationand translation inhibition of non-poly(A)mRNAs; forms complex with Ski2p and Ski8p;required for repressing propagation of dsRNAviruses 0.002180.03899&radic&radic&radic&radic S000003834OPI3YJR073CverifiedPhospholipid methyltransferase(methylene-fatty-acyl-phospholipid synthase),catalyzes the last two steps inphosphatidylcholine biosynthesis 0.002190.03899 S000002210SLC1YDL052Cverified1-acyl-sn-gylcerol-3-phosphate acyltransferase, catalyzes theacylation of lysophosphatidic acid to formphosphatidic acid, a key intermediate in lipidmetabolism; located in lipid particles andendoplasmic reticulum 0.002180.03893&radic S000002454HEM12YDR047WverifiedUroporphyrinogen decarboxylase, catalyzes the fifth step in theheme biosynthetic pathway; localizes to boththe cytoplasm and nucleus; activity inhibitedby Cu2+, Zn2+, Fe2+, Fe3+ andsulfhydryl-specific reagents 0.002160.03861&radic S000003459DIE2YGR227WverifiedDolichyl-phosphoglucose-dependent glucosyltransferase of theER, functions in the dolichol pathway thatsynthesizes the dolichol-linked oligosaccharideprecursor for N-linked protein glycosylation,has a role in regulation of ITR1 and INO1 0.002170.03861&radic&radic S000005334BRE5YNR051CverifiedUbiquitin protease cofactor, forms deubiquitination complexwith Ubp3p that coregulates anterograde andretrograde transport between the endoplasmicreticulum and Golgi compartments; null issensitive to brefeldin A 0.002150.03861&radic&radic&radic S000000002VPS8YAL002WverifiedMembrane-associated hydrophilic protein that interacts with thesmall GTPase, Vps21p, to facilitate solublevacuolar protein localization; required forlocalization and trafficking of the CPY sortingreceptor; contains a RING finger motif 0.002150.03858&radic&radic S000004624QRI8YMR022WverifiedUbiquitin conjugating enzyme, involved in the ER-associatedprotein degradation pathway; requires Cue1p forrecruitment to the ER membrane; proposed to beinvolved in chromatin assembly 0.002150.03854&radic S000003304UPF3YGR072WverifiedComponent of the nonsense-mediated mRNA decay (NMD) pathway,along with Nam7p and Nmd2p; involved in decayof mRNA containing nonsense codons; involved intelomere maintenance 0.002150.03849&radic S000005313ALG12YNR030WverifiedAlpha-1,6-mannosyltransferase localized to the ER; responsiblefor the addition of the alpha-1,6 mannose todolichol-linked Man7GlcNAc2, acts in t