Yfunc lets you browse current and predicted gene functions in yeast

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Prediction of GO:0019887 "protein kinase regulator activity"

GO branch: MF
Number of currently annotated genes: 44

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest PS00292IPR006671Lum:TroglitazoneIPR011068Lee:SWI5IPR013922Lum:MenadioneHarbison:CIN5_H2O2HiHarbison:MBP1_YPDIPR006670 S000006177CLN2YPL256CverifiedG1 cyclin involved in regulation of the cell cycle; activatesCdc28p kinase to promote the G1 to S phasetransition; late G1 specific expression dependson transcription factor complexes, MBF(Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) &radic0.776121&radic&radic&radic&radic&radic S000000038CLN3YAL040CverifiedG1 cyclin involved in cell cycle progression; activates Cdc28pkinase to promote the G1 to S phase transition;plays a role in regulating transcription of theother G1 cyclins, CLN1 and CLN2; regulated byphosphorylation and proteolysis &radic0.781891&radic&radic&radic&radic S000006323CLB2YPR119WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the transition from G2 to Mphase; accumulates during G2 and M, thentargeted via a destruction box motif forubiquitin-mediated degradation by theproteasome &radic0.765861&radic&radic&radic&radic S000003341CLB6YGR109CverifiedB-type cyclin involved in DNA replication during S phase;activates Cdc28p to promote initiation of DNAsynthesis; functions in formation of mitoticspindles along with Clb3p and Clb4p; mostabundant during late G1 &radic0.768291&radic&radic&radic&radic&radic S000006324CLB5YPR120CverifiedB-type cyclin involved in DNA replication during S phase;activates Cdc28p to promote initiation of DNAsynthesis; functions in formation of mitoticspindles along with Clb3p and Clb4p; mostabundant during late G1 phase &radic0.761541&radic&radic&radic&radic&radic S000004812CLN1YMR199WverifiedG1 cyclin involved in regulation of the cell cycle; activatesCdc28p kinase to promote the G1 to S phasetransition; late G1 specific expression dependson transcription factor complexes, MBF(Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) &radic0.718110.98165&radic&radic&radic&radic&radic S000002314CLB3YDL155WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the G2/M transition; may beinvolved in DNA replication and spindleassembly; accumulates during S phase and G2,then targeted for ubiquitin-mediateddegradation &radic0.701980.98165&radic&radic&radic&radic S000003340CLB1YGR108WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the transition from G2 to Mphase; accumulates during G2 and M, thentargeted via a destruction box motif forubiquitin-mediated degradation by theproteasome &radic0.67420.9752&radic&radic&radic&radic S000006229CCL1YPR025CverifiedCyclin associated with protein kinase Kin28p, which is theTFIIH-associated carboxy-terminal domain (CTD)kinase involved in transcription initiation atRNA polymerase II promoters &radic0.640720.95823&radic&radic&radic S000005361PHO80YOL001WverifiedCyclin, negatively regulates phosphate metabolism;Pho80p-Pho85p (cyclin-CDK complex)phosphorylates Pho4p and Swi5p; deletion ofPHO80 leads to aminoglycoside supersensitivity;truncated form of PHO80 affects vacuoleinheritance &radic0.571740.95823&radic&radic&radic&radic S000002285PCL2YDL127WverifiedG1 cyclin, associates with Pho85p cyclin-dependent kinase (Cdk)to contribute to entry into the mitotic cellcycle, essential for cell morphogenesis;localizes to sites of polarized cell growth &radic0.497330.94666&radic&radic&radic&radic&radic S000005233PCL1YNL289WverifiedPho85 cyclin of the Pcl1,2-like subfamily, involved in entryinto the mitotic cell cycle and regulation ofmorphogenesis, localizes to sites of polarizedcell growth &radic0.478350.94051&radic&radic&radic&radic S000004970SSN8YNL025CverifiedCyclin-like component of the RNA polymerase II holoenzyme,involved in phosphorylation of the RNApolymerase II C-terminal domain; involved inglucose repression and telomere maintenance &radic0.473030.93944&radic&radic&radic S000004200CLB4YLR210WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the G2/M transition; may beinvolved in DNA replication and spindleassembly; accumulates during S phase and G2,then targeted for ubiquitin-mediateddegradation &radic0.458380.93469&radic&radic&radic&radic&radic S000001113PCL5YHR071WverifiedCyclin, interacts with Pho85p cyclin-dependent kinase (Cdk),induced by Gcn4p at level of transcription,specifically required for Gcn4p degradation,may be sensor of cellular protein biosyntheticcapacity &radic0.382910.93376&radic&radic&radic&radic S000003543CTK2YJL006CverifiedBeta subunit of C-terminal domain kinase I (CTDK-I), whichphosphorylates the C-terminal repeated domainof the RNA polymerase II large subunit (Rpo21p)to affect both transcription and pre-mRNA 3'end processing; has similarity to cyclins &radic0.360320.92528&radic&radic&radic S000003478BRF1YGR246CverifiedTFIIIB B-related factor, one of three subunits of RNApolymerase III transcription initiation factorTFIIIB, binds TFIIIC and TBP and recruits RNApol III to promoters, amino-terminal half ishomologous to TFIIB 0.330640.91149&radic&radic S000002987CKB1YGL019WverifiedBeta regulatory subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKA2 and CKB2, the many substratesinclude transcription factors and all RNApolymerases &radic0.29680.89039&radic S000001312PCL7YIL050WverifiedPho85p cyclin of the Pho80p subfamily, forms a functionalkinase complex with Pho85p which phosphorylatesMmr1p and is regulated by Pho81p; involved inglycogen metabolism, expression is cell-cycleregulated &radic0.289460.88692&radic&radic&radic&radic S000005565CKB2YOR039WverifiedBeta' regulatory subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKA2 and CKB1, the many substratesinclude transcription factors and all RNApolymerases &radic0.275070.88409 S000003070YGL102CDubiousHypothetical protein; open reading frame overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein 0.254770.87656 S000003542CYR1YJL005WverifiedAdenylate cyclase, required for cAMP production andcAMP-dependent protein kinase signaling;involved in cell cycle control and glucose andnitrogen repression of sporulation 0.24240.8654 S000006290SUA7YPR086WverifiedTranscription factor TFIIB, a general transcription factorrequired for transcription initiation and startsite selection by RNA polymerase II 0.237390.86044&radic S000003183CLG1YGL215WverifiedCyclin-like protein that interacts with Pho85p; has sequencesimilarity to G1 cyclins PCL1 and PCL2 &radic0.209410.83666&radic&radic&radic&radic S000000861PCL6YER059WverifiedPho85p cyclin of the Pho80p subfamily; forms the major Glc8pkinase together with Pcl7p and Pho85p; involvedin the control of glycogen storage by Pho85p;stabilized by Elongin C binding &radic0.168190.79303&radic&radic S000004216BUR2YLR226WverifiedCyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2pcomprise a CDK-cyclin complex involved intranscriptional regulation through itsphosphorylation of the carboxy-terminal domainof the largest subunit of RNA polymerase II &radic0.168080.7929&radic&radic S000000372PEX32YBR168WverifiedPeroxisomal integral membrane protein, involved in negativeregulation of peroxisome size; partiallyfunctionally redundant with Pex31p; geneticinteractions suggest action at a stepdownstream of steps mediated by Pex28p andPex29p 0.123130.72447&radic S000004354STE11YLR362WverifiedSignal transducing MEK kinase involved in pheromone responseand pseudohyphal/invasive growth pathways whereit phosphorylates Ste7p, and the highosmolarity response pathway, viaphosphorylation of Pbs2p; regulated by Ste20pand Ste50p 0.110130.7002 S000000950SPT15YER148WverifiedTATA-binding protein, general transcription factor thatinteracts with other factors to form thepreinitiation complex at promoters, essentialfor viability 0.080120.62911 S000002139YAL056C-ADubiousHypothetical protein 0.072150.60068&radic&radic S000003102PCL10YGL134WverifiedPho85p cyclin; recruits, activates, and targets Pho85pcyclin-dependent protein kinase to itssubstrate &radic0.071980.60068&radic S000005082SRV2YNL138WverifiedCAP (cyclase-associated protein) subunit of adenylyl cyclasecomplex; N-terminus binds adenylyl cyclase andfacilitates activation by RAS; C-terminus bindsADP-actin monomers, facilitating regulation ofactin dynamics and cell morphogenesis 0.06770.58506 S000001297CKA1YIL035CverifiedAlpha catalytic subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA2, CKB1 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.060120.55697 S000000364CDC28YBR160WverifiedCatalytic subunit of the main cell cycle cyclin-dependentkinase (CDK); alternately associates with G1cyclins (CLNs) and G2/M cyclins (CLBs) whichdirect the CDK to specific substrates 0.055850.53788 S000001313MMF1YIL051CverifiedMitochondrial protein involved in maintenance of themitochondrial genome 0.052930.52294&radic&radic S000001710PAP1YKR002WverifiedPoly(A) polymerase, one of three factors required for mRNA3'-end polyadenylation, forms multiproteincomplex with polyadenylation factor I (PF I),also required for mRNA nuclear export; may alsopolyadenylate rRNAs 0.053080.52294&radic S000004334FKS1YLR342WverifiedCatalytic subunit of 1,3-beta-D-glucan synthase, functionallyredundant with alternate catalytic subunitGsc2p; binds to regulatory subunit Rho1p;involved in cell wall synthesis andmaintenance; localizes to sites of cell wallremodeling 0.05010.50824&radic&radic S000002868TFB3YDR460WverifiedSubunit of TFIIH and nucleotide excision repair factor 3complexes, involved in transcriptioninitiation, required for nucleotide excisionrepair; ring finger protein similar tomammalian CAK and TFIIH subunit 0.048590.50024 S000001855ACT1YFL039CverifiedActin, structural protein involved in cell polarization,endocytosis, and other cytoskeletal functions 0.048510.50024&radic S000004524NTE1YML059CverifiedSerine esterase that deacylates exogenous lysophospholipids,homolog of human neuropathy target esterase(NTE); mammalian NTE1 deacylatesphosphatidylcholine to glycerophosphocholine 0.045690.48918 S000005872YOR345CDubiousHypothetical protein 0.04530.48813&radic&radic S000003165MDS3YGL197WverifiedProtein with an N-terminal kelch-like domain, putative negativeregulator of early meiotic gene expression;required, with Pmd1p, for growth under alkalineconditions 0.044140.48165 S000000922SCS2YER120WverifiedIntegral ER membrane protein that regulates phospholipidmetabolism via an interaction with the FFATmotif of Opi1p, also involved in telomericsilencing, disruption causes inositolauxotrophy above 34 degrees C, VAP homolog 0.042650.47389 S000000065RFA1YAR007CverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 0.039110.46106&radic&radic&radic S000001566YKL083WDubiousDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14 0.038630.45954&radic&radic S000004069SIC1YLR079WverifiedInhibitor of Cdc28-Clb kinase complexes that controls G1/Sphase transition, preventing premature S phaseand ensuring genomic integrity; phosphorylationtargets Sic1p for SCF(CDC4)-dependent turnover;functional homolog of mammalian Kip1 0.037140.45295&radic&radic S000005873REV1YOR346WverifiedDeoxycytidyl transferase, forms a complex with the subunits ofDNA polymerase zeta, Rev3p and Rev7p; involvedin repair of abasic sites in damaged DNA 0.037040.45295&radic&radic&radic S000006260TFB4YPR056WverifiedSubunit of TFIIH complex, involved in transcription initiation,similar to 34 kDa subunit of human TFIIH;interacts with Ssl1p 0.036910.45106 S000002557NUM1YDR150WverifiedProtein required for nuclear migration, localizes to the mothercell cortex and the bud tip; may mediateinteractions of dynein and cytoplasmicmicrotubules with the cell cortex 0.036510.45106&radic S000001649TPK3YKL166CverifiedSubunit of cAMP-dependent protein kinase, which contains Tpk1p,Tpk2p, Tpk3p, and regulatory subunit Bcy1p;promotes growth in response to nutrients;mediates induction of apoptosis due toactin-mediated hyperactivation of Ras signaling 0.035280.44363&radic S000003176SIP2YGL208WverifiedOne of three beta subunits of the Snf1 serine/threonine proteinkinase complex involved in the response toglucose starvation; null mutants exhibitaccelerated aging; N-myristoylprotein localizedto the cytoplasm and the plasma membrane 0.034120.43807&radic S000000829GAL83YER027CverifiedOne of three possible beta-subunits of the Snf1 kinase complex,allows nuclear localization of the Snf1 kinasecomplex in the presence of a nonfermentablecarbon source; contains glycogen-binding domain 0.033640.43661&radic S000003631BCK1YJL095WverifiedMitogen-activated protein (MAP) kinase kinase kinase acting inthe protein kinase C signaling pathway, whichcontrols cell integrity; upon activation byPkc1p phosphorylates downstream kinases Mkk1pand Mkk2p 0.032590.4319 S000005182KEX2YNL238WverifiedSubtilisin-like protease (proprotein convertase), acalcium-dependent serine protease involved inthe activation of proproteins of the secretorypathway 0.032210.42879&radic S000006124TPK2YPL203WverifiedSubunit of cytoplasmic cAMP-dependent protein kinase, whichcontains redundant catalytic subunits Tpk1p,Tpk2p, and Tpk3p and regulatory subunit Bcy1p;promotes vegetative growth in response tonutrients; activates filamentous growth 0.032220.42879&radic S000001101FYV4YHR059WverifiedProtein of unknown function, required for survival uponexposure to K1 killer toxin 0.031790.42736&radic S000000181BOI1YBL085WverifiedProtein implicated in polar growth, functionally redundant withBoi2p; interacts with bud-emergence proteinBem1p; contains an SH3 (src homology 3) domainand a PH (pleckstrin homology) domain 0.031370.42516&radic&radic S000002719TFB1YDR311WverifiedSubunit of TFIIH and nucleotide excision repair factor 3complexes, required for nucleotide excisionrepair, target for transcriptional activators 0.031120.42451&radic S000004525OGG1YML060WverifiedMitochondrial glycosylase/lyase that specifically excises7,8-dihydro-8-oxoguanine residues locatedopposite cytosine or thymine residues in DNA,repairs oxidative damage to mitochondrial DNA 0.029890.41568 S000001029YHL037CDubiousHypothetical protein 0.028370.40479&radic&radic S000006184KEL3YPL263CverifiedCytoplasmic protein of unknown function 0.026530.39526&radic S000000081SWH1YAR042WverifiedProtein similar to mammalian oxysterol-binding protein;contains ankyrin repeats; localizes to theGolgi and the nucleus-vacuole junction 0.025790.38911&radic&radic S000003207CSE1YGL238WverifiedNuclear envelope protein that mediates the nuclear export ofimportin alpha (Srp1p), homolog of metazoan CASprotein, required for accurate chromosomesegregation 0.024920.38333&radic&radic&radic S000002177OSH2YDL019CverifiedMember of an oxysterol-binding protein family with sevenmembers in S. cerevisiae; family members haveoverlapping, redundant functions in sterolmetabolism and collectively perform a functionessential for viability 0.02440.37639 S000000979BMH1YER177Wverified14-3-3 protein, major isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others 0.024340.37639 S000001799SRL3YKR091WverifiedCytoplasmic protein that, when overexpressed, suppresses thelethality of a rad53 null mutation; potentialCdc28p substrate 0.02390.37374 S000005242CLA4YNL298WverifiedCdc42p activated signal transducing kinase of the PAK(p21-activated kinase) family, involved inseptin ring assembly and cytokinesis; directlyphosphorylates septins Cdc3p and Cdc10p; otheryeast PAK family members are Ste20p and Skm1p 0.023460.37027&radic&radic S000001028MUP3YHL036WverifiedLow affinity methionine permease, similar to Mup1p 0.023380.37027&radic S000003470KEL2YGR238CverifiedProtein that functions in a complex with Kel1p to negativelyregulate mitotic exit, interacts with Tem1p andLte1p; localizes to regions of polarizedgrowth; potential Cdc28p substrate 0.022620.36439&radic S000001198YSP1YHR155WuncharacterizedMitochondrial protein with a potential role in promotingmitochondrial fragmentation during programmedcell death in response to high levels ofalpha-factor mating pheromone or the drugamiodarone 0.022570.36439&radic S000005935YPL014WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus 0.0220.35988 S000001319YIL057CUncharacterizedHypothetical protein 0.022060.35988&radic&radic S000002885SNF1YDR477WverifiedAMP-activated serine/threonine protein kinase found in acomplex containing Snf4p and members of theSip1p/Sip2p/Gal83p family; required fortranscription of glucose-repressed genes,thermotolerance, sporulation, and peroxisomebiogenesis 0.021630.3569 S000000339CKS1YBR135WverifiedSubunit of the Cdc28 protein kinase, required for mitoticproteolysis, may also be involved in theproteolysis of the G1 cyclins &radic0.021360.35542 S000004296STT4YLR305CverifiedPhosphatidylinositol-4-kinase that functions in the Pkc1pprotein kinase pathway; required for normalvacuole morphology, cell wall integrity, andactin cytoskeleton organization 0.020880.35061&radic S000003465PHO81YGR233CverifiedCyclin-dependent kinase (CDK) inhibitor, regulatesPho80p-Pho85p and Pcl7p-Pho85p cyclin-CDKcomplexes in response to phosphate levels;required for derepression of PHO5;transcriptionally regulated by Pho4p and Pho2p &radic0.020760.35061&radic&radic&radic S000006220TIF6YPR016CverifiedConstituent of 66S pre-ribosomal particles, has similarity tohuman translation initiation factor 6 (eIF6);may be involved in the biogenesis and orstability of 60S ribosomal subunits 0.020910.35061 S000001243RPN10YHR200WverifiedNon-ATPase base subunit of the 19S regulatory particle (RP) ofthe 26S proteasome; N-terminus plays a role inmaintaining the structural integrity of the RP;binds selectively to polyubiquitin chains;homolog of the mammalian S5a protein 0.02070.35009&radic S000001939IRC6YFR043CuncharacterizedHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 0.020020.34347&radic&radic S000000934PMD1YER132CverifiedProtein with an N-terminal kelch-like domain, putative negativeregulator of early meiotic gene expression;required, with Mds3p, for growth under alkalineconditions 0.019960.3429 S000002435REG1YDR028CverifiedRegulatory subunit of type 1 protein phosphatase Glc7p,involved in negative regulation ofglucose-repressible genes 0.019950.3429 S000000285SPT7YBR081CverifiedSubunit of the SAGA transcriptional regulatory complex,involved in proper assembly of the complex;also present as a C-terminally truncated formin the SLIK/SALSA transcriptional regulatorycomplex 0.020.3429 S000001201KEL1YHR158CverifiedProtein required for proper cell fusion and cell morphology;functions in a complex with Kel2p to negativelyregulate mitotic exit, interacts with Tem1p andLte1p; localizes to regions of polarizedgrowth; potential Cdc28p substrate 0.01970.34047 S000003995SSL1YLR005WverifiedComponent of the core form of RNA polymerase transcriptionfactor TFIIH, which has both protein kinase andDNA-dependent ATPase/helicase activities and isessential for transcription and nucleotideexcision repair; interacts with Tfb4p 0.01960.34015&radic S000001608RRN3YKL125WverifiedProtein required for transcription of rDNA by RNA polymerase I;transcription factor independent of DNAtemplate; involved in recruitment of RNApolymerase I to rDNA 0.019540.33959&radic&radic S000005699DCS2YOR173WverifiedNon-essential, stress induced regulatory protein containing aHIT (histidine triad) motif; modulatesm7G-oligoribonucleotide metabolism; inhibitsDcs1p; regulated by Msn2p, Msn4p, and theRas-cAMP-cAPK signaling pathway, similar toDcs1p. 0.019020.3342 S000001126STE12YHR084WverifiedTranscription factor that is activated by a MAP kinasesignaling cascade, activates genes involved inmating or pseudohyphal/invasive growthpathways; cooperates with Tec1p transcriptionfactor to regulate genes specific for invasivegrowth 0.018970.3342 S000005940VTC3YPL019CverifiedVacuolar membrane protein involved in vacuolar polyphosphateaccumulation; functions as a regulator ofvacuolar H+-ATPase activity and vacuolartransporter chaperones; involved innon-autophagic vacuolar fusion 0.018850.3337&radic S000000499PCA1YBR295WverifiedCadmium transporting P-type ATPase; may also have a role incopper and iron homeostasis; S288C and mostother lab strains contain a G970R mutationwhich eliminates normal cadmium transportfunction 0.018630.33194 S000002520PDS1YDR113CverifiedSecurin that inhibits anaphase by binding separin Esp1p, alsoblocks cyclin destruction and mitotic exit,essential for cell cycle arrest in mitosis inthe presence of DNA damage or aberrant mitoticspindles; also present in meiotic nuclei 0.01850.32984&radic&radic&radic S000003549VTC4YJL012CverifiedVacuolar membrane protein involved in vacuolar polyphosphateaccumulation; functions as a regulator ofvacuolar H+-ATPase activity and vacuolartransporter chaperones; involved innon-autophagic vacuolar fusion 0.018410.32984 S000003723SWE1YJL187CverifiedProtein kinase that regulates the G2/M transition by inhibitionof Cdc28p kinase activity; localizes to thenucleus and to the daughter side of themother-bud neck; homolog of S. pombe Wee1p;potential Cdc28p substrate 0.017460.32076&radic&radic S000000561YCL056CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.017090.31766&radic S000002638YDR230WDubiousHypothetical protein 0.01730.31766&radic&radic S000006236SRO7YPR032WverifiedPutative effector of Rab GTPase Sec4p, forms a complex withSec4p and t-SNARE Sec9p; involved in exocytosisand docking and fusion of post-Golgi vesicleswith plasma membrane; homolog of Sro77p andDrosophila lgl tumor suppressor 0.0170.3174 S000001012OPI1YHL020CverifiedTranscriptional regulator of a variety of genes;phosphorylation by protein kinase A stimulatesOpi1p function in negative regulation ofphospholipid biosynthetic genes; involved intelomere maintenance 0.016280.31017 S000000058GDH3YAL062WverifiedNADP(+)-dependent glutamate dehydrogenase, synthesizesglutamate from ammonia and alpha-ketoglutarate;rate of alpha-ketoglutarate utilization differsfrom Gdh1p; expression regulated by nitrogenand carbon sources 0.016260.31017&radic&radic&radic S000003421CRH1YGR189CverifiedPutative glycosidase of the cell wall, may have a role in cellwall architecture 0.016210.30861&radic&radic S000006257YPR053CDubiousHypothetical protein 0.016080.30861&radic S000005587CKA2YOR061WverifiedAlpha' catalytic subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKB1 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.015990.3056&radic&radic S000006259SEC8YPR055WverifiedEssential 121kDa subunit of the exocyst complex (Sec3p, Sec5p,Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, andExo84p), which has the essential function ofmediating polarized targeting of secretoryvesicles to active sites of exocytosis 0.015970.3056&radic S000002251PMT5YDL093WverifiedProtein O-mannosyltransferase, transfers mannose residues fromdolichyl phosphate-D-mannose to proteinserine/threonine residues; acts in a complexwith Pmt3p, can instead interact with Pmt2p insome conditions; target for new antifungals 0.015480.3002&radic S000003722MNN5YJL186WverifiedAlpha-1,2-mannosyltransferase, responsible for addition of thesecond alpha-1,2-linked mannose of the brancheson the mannan backbone of oligosaccharides,localizes to an early Golgi compartment 0.015410.3002&radic&radic S000002254OPI6YDL096CdubiousDubious open reading frame unlikely to encode a protein, basedon available experimental and comparativesequence data; partially overlaps verified genePMT1/YDL095W; YDL096C is not essential 0.01510.29715&radic S000004248GSY2YLR258WverifiedGlycogen synthase, similar to Gsy1p; expression induced byglucose limitation, nitrogen starvation, heatshock, and stationary phase; activity regulatedby cAMP-dependent, Snf1p and Pho85p kinases aswell as by the Gac1p-Glc7p phosphatase 0.01490.29539&radic S000006031GDE1YPL110CverifiedGlycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzesGroPCho to choline and glycerolphosphate, foruse as a phosphate source and as a precursorfor phosphocholine synthesis; may interact withribosomes 0.014830.29527&radic S000005079FPR1YNL135CverifiedPeptidyl-prolyl cis-trans isomerase (PPIase), binds to thedrugs FK506 and rapamycin; also binds to thenonhistone chromatin binding protein Hmo1p andmay regulate its assembly or function 0.01460.28925 S000005501PPM2YOL141WverifiedPutative carboxyl methyl transferase, has similarity to Ppm1pbut biochemical activity not yet demonstrated;the authentic, non-tagged protein is detectedin highly purified mitochondria inhigh-throughput studies 0.014150.28682 S000005666SFL1YOR140WverifiedTranscription repressor involved in regulation offlocculation-related genes, inhibitstranscription by recruiting general corepressorCyc8p-Tup1p to different promoters; negativelyregulated by cAMP-dependent protein kinase Asubunit Tpk2p 0.014040.28601&radic S000002636PCF11YDR228CverifiedmRNA 3' end processing factor, essential component of cleavageand polyadenylation factor IA (CF IA), involvedin pre-mRNA 3' end processing and intranscription termination; binds C-terminaldomain of largest subunit of RNA pol II(Rpo21p) 0.013860.28407&radic S000000112FUS3YBL016WverifiedMitogen-activated protein kinase involved in mating pheromoneresponse; activated by phosphorylation bySte7p; provides specificity during the matingvs. filamentous growth response byphosphorylating transcriptional and cytoplasmictargets 0.013840.28351&radic&radic S000000066SEN34YAR008WverifiedSubunit of the tRNA splicing endonuclease, which is composed ofSen2p, Sen15p, Sen34p, and Sen54p; Sen34pcontains the active site for tRNA 3' splicesite cleavage and has similarity to Sen2p andto Archaeal tRNA splicing endonuclease 0.013690.28107&radic&radic&radic S000006256NHP6AYPR052CverifiedHigh-mobility group non-histone chromatin protein, functionallyredundant with Nhp6Bp; homologous to mammalianhigh mobility group proteins 1 and 2; acts torecruit transcription factor Rcs1p to certainpromoters 0.013540.27697&radic S000003212TAD1YGL243WverifiedtRNA-specific adenosine deaminase, deaminates adenosine-37 toinosine in tRNA-Ala 0.013460.27697&radic S000005215BNI1YNL271CverifiedFormin, nucleates the formation of linear actin filaments,involved in cell processes such as budding andmitotic spindle orientation which require theformation of polarized actin cables,functionally redundant with BNR1 0.013540.27697&radic&radic&radic S000002996SCW11YGL028CverifiedCell wall protein with similarity to glucanases; may play arole in conjugation during mating based on itsregulation by Ste12p 0.013290.27697&radic&radic&radic S000003494BUD32YGR262CverifiedProtein kinase proposed to be involved in bud-site selection,telomere uncapping and elongation, andtranscription; component of the EKC/KEOPSprotein complex with Kae1p, Cgi121p, Pcc1p, andGon7p 0.01350.27697&radic&radic&radic S000004520IMD4YML056CverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 0.013240.2764 S000002744YDR336WUncharacterizedPutative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene 0.013130.27519&radic&radic S000005886VTS1YOR359WverifiedPost-transcriptional gene regulator, RNA-binding proteincontaining a SAM domain; shows geneticinteractions with Vti1p, which is a v-SNAREinvolved in cis-Golgi membrane traffic 0.013040.27397&radic S000003148ATG1YGL180WverifiedProtein serine/threonine kinase, required for autophagy and forthe cytoplasm-to-vacuole targeting (Cvt)pathway 0.012930.27231 S000004633YMR031CUncharacterizedPutative protein of unknown function with similarity to YKL050C and USO1/YDL058W; found in mitochondria; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR031C is not an essential gene 0.012710.26994&radic S000003954GPI13YLL031CverifiedER membrane localized phosphoryltransferase that addsphosphoethanolamine onto the third mannoseresidue of the glycosylphosphatidylinositol(GPI) anchor precursor; similar to human PIG-Oprotein 0.012560.26917&radic&radic&radic S000000560KAR4YCL055WverifiedTranscription factor required for gene regulation in repsonseto pheromones; also required during meiosis;exists in two forms, a slower-migrating formmore abundant during vegetative growth and afaster-migrating form induced by pheromone 0.012530.26905&radic&radic&radic S000002637IVY1YDR229WverifiedPhospholipid-binding protein that interacts with both Ypt7p andVps33p, may partially counteract the action ofVps33p and vice versa, localizes to the rim ofthe vacuole as cells approach stationary phase 0.012390.26492&radic S000005509DCP1YOL149WverifiedSubunit of the Dcp1p-Dcp2p decapping enzyme complex, whichremoves the 5' cap structure from mRNAs priorto their degradation; enhances the activity ofcatalytic subunit Dcp2p; regulated by DEAD boxprotein Dhh1p 0.01250.26492 S000001385SIM1YIL123WverifiedProtein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that mayparticipate in DNA replication, promotercontains SCB regulation box at -300 bpindicating that expression may be cellcycle-regulated 0.012030.26147 S000003734PHO90YJL198WverifiedLow-affinity phosphate transporter; deletion of pho84, pho87,pho89, pho90, and pho91 causes syntheticlethality; transcription independent of Pi andPho4p activity; overexpression results invigorous growth 0.012010.26147&radic S000000461POP4YBR257WverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends; binds to the RPR1 RNAsubunit in Rnase P 0.012060.26147&radic S000003743LAA1YJL207CverifiedProtein of unknown function, proposed to function as a largeAP-1 accessory protein; colocalizes withclathrin to the late-Golgi apparatus; YJL207Cis a non-essential gene 0.011770.25795&radic&radic&radic S000002717GIC2YDR309CverifiedProtein of unknown function involved in initiation of buddingand cellular polarization, interacts withCdc42p via the Cdc42/Rac-interactive binding(CRIB) domain 0.011710.25795&radic S000001309SYG1YIL047CverifiedPlasma membrane protein of unknown function; truncation andoverexpression suppresses lethality of G-alphaprotein deficiency 0.011730.25795 S000003693FAR1YJL157CverifiedCyclin-dependent kinase inhibitor that mediates cell cyclearrest in response to pheromone; also forms acomplex with Cdc24p, Ste4p, and Ste18p that mayspecify the direction of polarized growthduring mating; potential Cdc28p substrate &radic0.011680.25795&radic&radic&radic S000002830SIP1YDR422CverifiedAlternate beta-subunit of the Snf1p kinase complex, may confersubstrate specificity; vacuolar proteincontaining KIS (Kinase-Interacting Sequence)and ASC (Association with Snf1 kinase Complex)domains involved in protein interactions 0.011650.25625&radic&radic S000003846STE18YJR086WverifiedG protein gamma subunit, forms a dimer with Ste4p to activatethe mating signaling pathway, forms aheterotrimer with Gpa1p and Ste4p to dampensignaling; C-terminus is palmitoylated andfarnesylated, which are required for normalsignaling 0.011630.25625 S000003357YGR125WUncharacterizedPutative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole 0.011480.25513&radic S000004339KAP95YLR347CverifiedKaryopherin beta, forms a dimeric complex with Srp1p (Kap60p)that mediates nuclear import of cargo proteinsvia a nuclear localization signal (NLS),interacts with nucleoporins to guide transportacross the nuclear pore complex 0.011430.25452&radic&radic S000001470DAL7YIR031CverifiedMalate synthase, role in allantoin degradation unknown;expression sensitive to nitrogen cataboliterepression and induced by allophanate, anintermediate in allantoin degradation 0.011330.25117 S000004968FAP1YNL023CverifiedProtein that binds to Fpr1p (FKBP12), conferring rapamycinresistance by competing with rapamycin forFpr1p binding; has similarity to putativetranscription factors, including D.melanogaster shuttle craft and human NFX1 0.011390.25117 S000002743MSN5YDR335WverifiedKaryopherin involved in nuclear import and export; shown to beresponsible for nuclear import of replicationprotein A and for export of several proteinsincluding Swi6p, Far1p, and Pho4p; cargodissociation involves binding to RanGTP 0.011320.25117&radic&radic S000005585YOR059CUncharacterizedHypothetical protein 0.011210.25117&radic&radic&radic S000000873YER071CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.011360.25117&radic&radic&radic S000001052RPL27AYHR010WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl27Bp and has similarity to ratL27 ribosomal protein 0.011150.25067&radic S000001511TFA1YKL028WverifiedTFIIE large subunit, involved in recruitment of RNA polymeraseII to the promoter, activation of TFIIH, andpromoter opening 0.010950.24793&radic S000005136CHS1YNL192WverifiedChitin synthase I, requires activation from zymogenic form inorder to catalyze the transfer ofN-acetylglucosamine (GlcNAc) to chitin;required for repairing the chitin septum duringcytokinesis; transcription activated by matingfactor 0.010980.24793&radic&radic&radic S000005296PHO91YNR013CverifiedLow-affinity phosphate transporter; deletion of pho84, pho87,pho89, pho90, and pho91 causes syntheticlethality; transcription independent of Pi andPho4p activity; overexpression results invigorous growth 0.0110.24793 S000003245SNU71YGR013WverifiedComponent of U1 snRNP required for mRNA splicing viaspliceosome; yeast specific, no metazoancounterpart 0.010790.24542&radic&radic S000006354YPR150WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C 0.010610.24336 S000000183RPL23AYBL087CverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl23Bp and has similarity to E.coli L14 and rat L23 ribosomal proteins 0.01060.24336&radic&radic S000003453TOS2YGR221CverifiedProtein involved in localization of Cdc24p to the site of budgrowth; may act as a membrane anchor; localizesto the bud neck and bud tip; potentiallyphosphorylated by Cdc28p 0.01060.24139&radic&radic S000003387CYS4YGR155WverifiedCystathionine beta-synthase, catalyzes the synthesis ofcystathionine from serine and homocysteine, thefirst committed step in cysteine biosynthesis 0.010430.24093 S000004954IDP3YNL009WverifiedPeroxisomal NADP-dependent isocitrate dehydrogenase, catalyzesoxidation of isocitrate to alpha-ketoglutaratewith the formation of NADP(H+), required forgrowth on unsaturated fatty acids 0.010430.24093&radic&radic S000005097GIM3YNL153CverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.010390.23964&radic S000002128SBH1YER087C-BverifiedBeta subunit of the Sec61p ER translocation complex(Sec61p-Sss1p-Sbh1p); involved in proteintranslocation into the endoplasmic reticulum;interacts with the exocyst complex; homologousto Sbh2p 0.010390.23964&radic&radic S000002741YDR333CUncharacterizedHypothetical protein 0.010330.23916&radic&radic S000000388YBR184WUncharacterizedPutative protein of unknown function; YBR184W is not an essential gene 0.010270.23807&radic&radic S000005421MAM3YOL060CverifiedProtein required for normal mitochondrial morphology, hassimilarity to hemolysins 0.010240.23692&radic S000000633PHO87YCR037CverifiedLow-affinity inorganic phosphate (Pi) transporter, involved inactivation of PHO pathway; expression isindependent of Pi concentration and Pho4pactivity; contains 12 membrane-spanningsegments 0.010230.23692&radic S000000027MYO4YAL029CverifiedOne of two type V myosin motors (along with MYO2) involved inactin-based transport of cargos; required formRNA transport, including ASH1 mRNA, andfacilitating the growth and movement of ERtubules into the growing bud along with She3p 0.010230.23692&radic&radic S000003801GEF1YJR040WverifiedChloride channel localized to late- or post-Golgi vesicles,involved in iron metabolism; highly homologousto voltage-gated chloride channels invertebrates 0.010140.23472 S000002794MUS81YDR386WverifiedHelix-hairpin-helix protein, involved in DNA repair andreplication fork stability; functions as anendonuclease in complex with Mms4p; interactswith Rad54p 0.010120.23472&radic S000003024SDS23YGL056CverifiedOne of two S. cerevisiae homologs (Sds23p and Sds24p) of theSchizosaccharomyces pombe Sds23 protein, whichgenetic studies have implicated inAPC/cyclosome regulation 0.010080.23472&radic S000000957BEM2YER155CverifiedRho GTPase activating protein (RhoGAP) involved in the controlof cytoskeleton organization and cellularmorphogenesis; required for bud emergence 0.010120.23472 S000000037CYC3YAL039CverifiedCytochrome c heme lyase (holocytochrome c synthase), attachesheme to apo-Cyc1p in the mitochondrialintermembrane space; human ortholog may have arole in microphthalmia with linear skin defects(MLS) 0.010010.23407&radic&radic S000006267YPR063CUncharacterizedHypothetical protein 0.009950.23286 S000001609YPK1YKL126WverifiedSerine/threonine protein kinase required for receptor-mediatedendocytosis; involved in sphingolipid-mediatedand cell integrity signaling pathways;localized to the bud neck, cytosol and plasmamembrane; homolog of mammalian kinase SGK 0.009850.23051&radic&radic S000002745MRPS28YDR337WverifiedMitochondrial ribosomal protein of the small subunit 0.009820.23051&radic S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.00980.23051&radic&radic&radic S000000004SSA1YAL005CverifiedATPase involved in protein folding and nuclear localizationsignal (NLS)-directed nuclear transport; memberof heat shock protein 70 (HSP70) family; formsa chaperone complex with Ydj1p; localized tothe nucleus, cytoplasm, and cell wall 0.009790.23051&radic&radic S000004424IMD3YLR432WverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 0.009880.23051 S000004791SPT21YMR179WverifiedProtein required for normal transcription at several lociincluding HTA2-HTB2 and HHF2-HHT2, but notrequired at the other histone loci;functionally related to Spt10p; involved intelomere maintenance 0.009710.22804&radic&radic&radic S000000677SRB8YCR081WverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation; involved in glucoserepression 0.009560.22647&radic S000001361SGA1YIL099WverifiedIntracellular sporulation-specific glucoamylase involved inglycogen degradation; induced during starvationof a/a diploids late in sporulation, butdispensable for sporulation 0.009520.22571 S000004490TSA1YML028WverifiedUbiquitous housekeeping thioredoxin peroxidase, reducesreactive oxygen, nitrogen and sulfur speciesusing thioredoxin as hydrogen donor; mediatesredox regulation of the nuclear localization ofYap1p; deletion results in mutator phenotype 0.009430.22372&radic&radic S000002439PST2YDR032CverifiedProtein with similarity to members of a family offlavodoxin-like proteins; induced by oxidativestress in a Yap1p dependent manner; theauthentic, non-tagged protein is detected inhighly purified mitochondria in high-throughputstudies 0.009420.22372 S000005952PHO85YPL031CverifiedCyclin-dependent kinase, with ten cyclin partners; involved inenvironmental stress response; inphosphate-rich conditions, Pho85p-Pho80pcomplex phosphorylates Pho4p which in turnrepresses PHO5 0.009380.22366&radic S000003318PIL1YGR086CverifiedPrimary component of eisosomes, which are large immobile patchstructures at the cell cortex associated withendocytosis, along with Lsp1p and Sur7p; nullmutants show activation of Pkc1p/Ypk1p stressresistance pathways &radic0.009310.2228&radic S000005216SEC2YNL272CverifiedGuanyl-nucleotide exchange factor for the small G-proteinSec4p, located on cytoplasmic vesicles;essential for post-Golgi vesicle transport 0.00920.22059&radic S000000025YAL027WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YAL027W is a non-essential gene 0.009230.22059&radic&radic S000001390MET18YIL128WverifiedDNA repair and TFIIH regulator, required for both nucleotideexcision repair (NER) and RNA polymerase II(RNAP II) transcription; involved in telomeremaintenance 0.009260.22059&radic S000000872RNR1YER070WverifiedRibonucleotide-diphosphate reductase (RNR), large subunit; theRNR complex catalyzes the rate-limiting step indNTP synthesis and is regulated by DNAreplication and DNA damage checkpoint pathwaysvia localization of the small subunits 0.009060.21791&radic&radic&radic S000004784DDR48YMR173WverifiedDNA damage-responsive protein, expression is increased inresponse to heat-shock stress or treatmentsthat produce DNA lesions; contains multiplerepeats of the amino acid sequence NNNDSYGS 0.0090.21633&radic S000000095IMD1YAR073WdubiousNonfunctional protein with homology to IMP dehydrogenase;probable pseudogene, located close to thetelomere; is not expressed at detectablelevels; YAR073W and YAR075W comprise acontinuous reading frame in some strains of S.cerevisiae 0.009040.21633 S000001259IMD2YHR216WverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, expression is induced bymycophenolic acid resulting in resistance tothe drug, expression is repressed by nutrientlimitation 0.009040.21633 S000003924DNM1YLL001WverifiedDynamin-related GTPase required for mitochondrial fission andthe maintenance of mitochondrial morphology,assembles on the cytoplasmic face ofmitochondrial tubules at sites at whichdivision will occur; also participates inendocytosis 0.008830.21367&radic S000002302CCT4YDL143WverifiedSubunit of the cytosolic chaperonin Cct ring complex, relatedto Tcp1p, required for the assembly of actinand tubulins in vivo 0.008820.2129&radic S000005704GAC1YOR178CverifiedRegulatory subunit for Glc7p type-1 protein phosphatase (PP1),tethers Glc7p to Gsy2p glycogen synthase, bindsHsf1p heat shock transcription factor, requiredfor induction of some HSF-regulated genes underheat shock 0.008780.21268&radic S000001367SLM1YIL105CverifiedPhosphoinositide PI4,5P(2) binding protein, forms a complexwith Slm2p; acts downstream of Mss4p in apathway regulating actin cytoskeletonorganization in response to stress; subunit ofand phosphorylated by the TORC2 complex 0.008740.21024 S000003461SMI1YGR229CverifiedProtein involved in the regulation of cell wall synthesis;proposed to be involved in coordinating cellcycle progression with cell wall integrity 0.008710.21024&radic S000002971CDH1YGL003CverifiedCell-cycle regulated activator of the anaphase-promotingcomplex/cyclosome (APC/C), which directsubiquitination of mitotic cyclins resulting inexit from mitosis; targets the APC/C tospecific substrates including CDC20, ASE1 andCIN8 0.008720.21024 S000000880YER078CUncharacterizedMetallopeptidase, localized to the mitochondrial matrix 0.008650.21024&radic&radic S000003730CDC6YJL194WverifiedEssential ATP-binding protein required for DNA replication,component of the pre-replicative complex(pre-RC) which requires ORC to associate withchromatin and is in turn required for Mcm2-7pDNA association; homologous to S. pombe Cdc18p 0.008550.20827&radic&radic S000000203YBL107CUncharacterizedHypothetical protein 0.008550.20827&radic S000003084CDC20YGL116WverifiedCell-cycle regulated activator of anaphase-promotingcomplex/cyclosome (APC/C), which is requiredfor metaphase/anaphase transition; directsubiquitination of mitotic cyclins, Pds1p, andother anaphase inhibitors; potential Cdc28psubstrate 0.008510.20686 S000001103GIC1YHR061CverifiedProtein of unknown function involved in initiation of buddingand cellular polarization, interacts withCdc42p via the Cdc42/Rac-interactive binding(CRIB) domain 0.008490.20686&radic&radic&radic S000000916BOI2YER114CverifiedProtein implicated in polar growth, functionally redundant withBoi1p; interacts with bud-emergence proteinBem1p; contains an SH3 (src homology 3) domainand a PH (pleckstrin homology) domain 0.008410.20607 S000001686TOR2YKL203CverifiedPIK-related protein kinase and rapamycin target; subunit ofTORC1, a complex that regulates growth inresponse to nutrients and TORC2, a complex thatregulates cell-cycle dependent polarization ofthe actin cytoskeleton; involved in meiosis 0.008290.20441&radic&radic S000002553SWI5YDR146CverifiedTranscription factor that activates transcription of genesexpressed at the M/G1 phase boundary and in G1phase; localization to the nucleus occursduring G1 and appears to be regulated byphosphorylation by Cdc28p kinase 0.008290.20441&radic&radic S000004301CDC25YLR310CverifiedMembrane bound guanine nucleotide exchange factor (GEF orGDP-release factor); indirectly regulatesadenylate cyclase through activation of Ras1pand Ras2p by stimulating the exchange of GDPfor GTP; required for progression through G1 0.008250.20284&radic&radic S000004872YMR259CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR259C is not an essential gene 0.008280.20284&radic&radic&radic S000000973RAD3YER171Wverified5' to 3' DNA helicase, involved in nucleotide excision repairand transcription; subunit of RNA polymerase IItranscription initiation factor TFIIH; subunitof Nucleotide Excision Repair Factor 3 (NEF3);homolog of human XPD protein 0.008250.20284 S000000052GPB2YAL056WverifiedProposed beta subunit of the heterotrimeric G protein;interacts with the receptor Grp1p, affectssignaling by altering the level ofphosphorylation of PKS substrates; regulatespseudohyphal growth through cAMP levels;homolog of Gpb1p &radic0.00820.20275&radic&radic&radic S000002831CAD1YDR423CverifiedAP-1-like bZIP transcriptional activator involved in multiplestress responses, iron metabolism, andpleiotropic drug resistance; controls a set ofgenes involved in stabilizing proteins, bindsconsensus sequence TTACTAA; 5' UTR containsuORFs 0.008180.20226&radic&radic S000004775PAH1YMR165CverifiedMg2+-dependent phosphatidate (PA) phosphatase,catalyzes the dephosphorylation of PA to yielddiacylglycerol and Pi, responsiblefor de novo lipid synthesis; homologous tomammalian lipin 1 0.008190.20226&radic&radic S000000070ADE1YAR015WverifiedN-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR)synthetase, required for 'de novo' purinenucleotide biosynthesis; red pigmentaccumulates in mutant cells deprived of adenine 0.008110.20061&radic&radic&radic S000003348SPT6YGR116WverifiedEssential protein that interacts with histones and is involvedin nucleosome disassembly and reassembly duringtranscription elongation 0.008110.20061 S000001646PIR3YKL163WverifiedO-glycosylated covalently-bound cell wall protein required forcell wall stability; expression is cell cycleregulated, peaking in M/G1 and also subject toregulation by the cell integrity pathway 0.008030.19915&radic S000004996COG5YNL051WverifiedComponent of the conserved oligomeric Golgi complex (Cog1pthrough Cog8p), a cytosolic tethering complexthat functions in protein trafficking tomediate fusion of transport vesicles to Golgicompartments 0.007990.19915 S000002522YDR115WUncharacterizedPutative mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins 0.00780.19606&radic&radic&radic S000003684RPA34YJL148WverifiedRNA polymerase I subunit A34.5 0.007770.19466&radic&radic S000000913SWI4YER111CverifiedDNA binding component of the SBF complex (Swi4p-Swi6p), atranscriptional activator that in concert withMBF (Mbp1-Swi6p) regulates late G1-specifictranscription of targets including cyclins andgenes required for DNA synthesis and repair 0.007680.19428&radic S000005089MFA2YNL145WverifiedMating pheromone a-factor, made by a cells; interacts withalpha cells to induce cell cycle arrest andother responses leading to mating; biogenesisinvolves C-terminal modification, N-terminalproteolysis, and export; also encoded by MFA1 0.007680.1942 S000001072SLT2YHR030CverifiedSerine/threonine MAP kinase involved in regulating themaintenance of cell wall integrity andprogression through the cell cycle; regulatedby the PKC1-mediated signaling pathway 0.007620.19301&radic S000000460RIB5YBR256CverifiedRiboflavin synthase; catalyzes the last step of the riboflavinbiosynthesis pathway 0.007610.19301&radic&radic S000000213HHF1YBR009CverifiedOne of two identical histone H4 proteins (see also HHF2); corehistone required for chromatin assembly andchromosome function; contributes to telomericsilencing; N-terminal domain involved inmaintaining genomic integrity 0.007520.19111 S000000119MCM2YBL023CverifiedProtein involved in DNA replication; component of the Mcm2-7hexameric complex that binds chromatin as apart of the pre-replicative complex 0.007440.19018&radic&radic S000000275YBR071WUncharacterizedHypothetical protein 0.007330.18791&radic S000004121ACE2YLR131CverifiedTranscription factor that activates expression of earlyG1-specific genes, localizes to daughter cellnuclei after cytokinesis and delays G1progression in daughters, localization isregulated by phosphorylation; potential Cdc28psubstrate 0.007310.18734 S000000520BUD3YCL014WverifiedProtein involved in bud-site selection and required for axialbudding pattern; localizes with septins to budneck in mitosis and may constitute an axiallandmark for next round of budding 0.007290.18734&radic&radic S000003614PRY3YJL078CverifiedProtein of unknown function, has similarity to Pry1p and Pry2pand to the plant PR-1 class of pathogen relatedproteins 0.007310.18734&radic S000000626SYP1YCR030CverifiedProtein with a potential role in actin cytoskeletalorganization; overexpression suppresses a pfy1(profilin) null mutation 0.00730.18734 S000005576YOR050CDubiousHypothetical protein 0.007260.18582&radic S000001222OYE2YHR179WverifiedWidely conserved NADPH oxidoreductase containing flavinmononucleotide (FMN), homologous to Oye3p withslight differences in ligand binding andcatalytic properties; may be involved in sterolmetabolism 0.007220.18582&radic&radic&radic S000001911GSY1YFR015CverifiedGlycogen synthase with similarity to Gsy2p, the more highlyexpressed yeast homolog; expression induced byglucose limitation, nitrogen starvation,environmental stress, and entry into stationaryphase 0.007240.18582 S000003336SRB5YGR104CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation; involved intelomere maintenance 0.007140.18431&radic S000000051PEX22YAL055WverifiedPutative peroxisomal membrane protein required for import ofperoxisomal proteins, functionally complementsa Pichia pastoris pex22 mutation 0.007170.18431&radic S000000242CHS2YBR038WverifiedChitin synthase II, requires activation from zymogenic form inorder to catalyze the transfer ofN-acetylglucosamine (GlcNAc) to chitin;required for the synthesis of chitin in theprimary septum during cytokinesis 0.007150.18431&radic S000005141WHI3YNL197CverifiedRNA binding protein that sequesters CLN3 mRNA in cytoplasmicfoci; cytoplasmic retention factor for Cdc28pand associated cyclins; regulates cell fate anddose-dependently regulates the critical cellsize required for passage through Start 0.007130.18406&radic S000002496YDR089WUncharacterizedHypothetical protein 0.007120.18319&radic S000001623TGL1YKL140WverifiedSteryl ester hydrolase, one of three gene products (Yeh1p,Yeh2p, Tgl1p) responsible for steryl esterhydrolase activity and involved in sterolhomeostasis; localized to lipid particlemembranes 0.007060.18264&radic S000001069RPN1YHR027CverifiedNon-ATPase base subunit of the 19S regulatory particle of the26S proteasome; may participate in therecognition of several ligands of theproteasome; contains a leucine-rich repeat(LRR) domain, a site for protein?proteininteractions 0.007060.18264&radic S000000999STE20YHL007CverifiedSignal transducing kinase of the PAK (p21-activated kinase)family, involved in pheromone response andpseudohyphal/invasive growth pathways,activated by Cdc42p; binds Ste4p at a GBB motifpresent in noncatalytic domains of PAK kinases 0.007060.18264 S000004919YMR304C-ADubiousHypothetical protein 0.006940.18016&radic S000004431MRPL4YLR439WverifiedMitochondrial ribosomal protein of the large subunit 0.006980.18016&radic&radic S000003805VPS55YJR044CverifiedLate endosomal protein involved in late endosome to vacuoletrafficking; functional homolog of humanobesity receptor gene-related protein (OB-RGRP) 0.007010.18016&radic&radic S000001357PRK1YIL095WverifiedProtein serine/threonine kinase; regulates the organization andfunction of the actin cytoskeleton through thephosphorylation of the Pan1p-Sla1p-End3pprotein complex 0.006970.18016 S000005775APC5YOR249CverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 0.006990.18016&radic S000001625MRP8YKL142WverifiedPutative mitochondrial ribosomal protein, has similarity to E.coli ribosomal protein S2 0.006920.1799&radic S000004415ATG17YLR423CverifiedProtein that interacts with and is required for activation ofApg1p protein kinase; involved in autophagy butnot in the Cvt (cytoplasm to vacuole targeting)pathway 0.006890.17933 S000000418SDS24YBR214WverifiedOne of two S. cerevisiae homologs (Sds23p and Sds24p) of theSchizosaccharomyces pombe Sds23 protein, whichgenetic studies have implicated inAPC/cyclosome regulation; may play an indirectrole in fluid-phase endocytosis 0.006870.17829&radic&radic S000002898PKH1YDR490CverifiedSerine/threonine protein kinase involved insphingolipid-mediated signaling pathway thatcontrols endocytosis; activates Ypk1p andYkr2p, components of signaling cascade requiredfor maintenance of cell wall integrity;redundant with Pkh2p 0.006860.17829 S000000459YBR255WUncharacterizedProtein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.006820.17791&radic S000004875YMR262WUncharacterizedProtein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene 0.006790.17733&radic&radic S000001721PRY2YKR013WverifiedProtein of unknown function, has similarity to Pry1p and Pry3pand to the plant PR-1 class of pathogen relatedproteins 0.006760.17666&radic S000000143EDE1YBL047CverifiedKey endocytic protein involved in a network of interactionswith other endocytic proteins, binds membranesin a ubiquitin-dependent manner, may also bindubiquitinated membrane-associated proteins 0.006780.17666&radic&radic S000003276RME1YGR044CverifiedZinc finger protein involved in control of meiosis; preventsmeiosis by repressing IME1 expression andpromotes mitosis by activating CLN2 expression;directly repressed by a1-a2 regulator; mediatescell type control of sporulation 0.006770.17666&radic&radic S000001924CDC14YFR028CverifiedProtein phosphatase required for mitotic exit; located in thenucleolus until liberated by the FEAR andMitotic Exit Network in anaphase, enabling itto act on key substrates to effect a decreasein CDK/B-cyclin activity and mitotic exit 0.006760.17666&radic S000003362YGR130CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7) 0.006750.17639&radic S000003107FLC3YGL139WverifiedPutative FAD transporter, similar to Flc1p and Flc2p; localizedto the ER 0.006750.17639&radic S000002752YDR344CDubiousHypothetical protein 0.006730.17605&radic S000002547MTQ2YDR140WuncharacterizedS-adenosylmethionine-dependent methyltransferase of the sevenbeta-strand family; methylates release factoreRF1 (Sup45p) in vitro; is not an essentialgene; similar to E.coli PrmC 0.006680.1752&radic&radic S000004914DYN3YMR299CverifiedDynein light intermediate chain (LIC); localizes with dynein,null mutant is defective in nuclear migration 0.006690.1752&radic&radic S000006130IPL1YPL209CverifiedAurora kinase involved in regulating kinetochore-microtubuleattachments; helps maintain condensedchromosomes during anaphase and earlytelophase; associates with Sli15p, whichpromotes Ipl1p association with mitotic spindle 0.006640.17302&radic S000005568CUE5YOR042WuncharacterizedProtein containing a CUE domain that binds ubiquitin, which mayfacilitate intramolecular monoubiquitination;green fluorescent protein (GFP)-fusion proteinlocalizes to the cytoplasm in a punctatepattern 0.006670.17302&radic S000001024GUT1YHL032CverifiedGlycerol kinase, converts glycerol to glycerol-3-phosphate;glucose repression of expression is mediated byAdr1p and Ino2p-Ino4p; derepression ofexpression on non-fermentable carbon sources ismediated by Opi1p and Rsf1p 0.006630.17302 S000000069BUD14YAR014CverifiedProtein involved in bud-site selection, Bud14p-Glc7p complexfunctions as a cortical regulator of dynein;diploid mutants display a random buddingpattern instead of the wild-type bipolarpattern 0.006520.17149&radic&radic&radic S000005738STE4YOR212WverifiedG protein beta subunit, forms a dimer with Ste18p to activatethe mating signaling pathway, forms aheterotrimer with Gpa1p and Ste18p to dampensignaling; may recruit Rho1p to the polarizedgrowth site during mating; contains WD40repeats 0.006520.17149&radic S000000193BRN1YBL097WverifiedEssential protein required for chromosome condensation, likelyto function as an intrinsic component of thecondensation machinery, may influence multipleaspects of chromosome transmission and dynamics 0.00650.17149&radic S000005442ATG19YOL082WverifiedProtein involved in the cytoplasm-to-vacuole targeting pathwayand in autophagy, recognizes cargo proteins anddelivers them to the preautophagosomalstructure for eventual engulfment by theautophagosome and degradation 0.006530.17149&radic S000004866YMR253CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene 0.006450.17044&radic S000005174ELA1YNL230CverifiedElongin A, F-box protein that forms a heterodimer with Elc1pand participates in transcription elongation 0.006470.17044&radic&radic S000000564KRR1YCL059CverifiedEssential nucleolar protein required for the synthesis of 18SrRNA and for the assembly of 40S ribosomalsubunit 0.006490.17044&radic S000003413TIM13YGR181WverifiedMitochondrial intermembrane space protein, forms a complex withTIm8p that mediates import and insertion of asubset of polytopic inner membrane proteins;may prevent aggregation of incoming proteins ina chaperone-like manner 0.006480.17044&radic&radic S000004219CDC42YLR229CverifiedSmall rho-like GTPase, essential for establishment andmaintenance of cell polarity; mutants havedefects in the organization of actin andseptins 0.006480.17044 S000000881YER079WUncharacterizedHypothetical protein 0.006420.16989&radic&radic&radic S000000368ARL1YBR164CverifiedSoluble GTPase with a role in regulation of membrane traffic;regulates potassium influx; G protein of theRas superfamily, similar to ADP-ribosylationfactor 0.00640.16913 S000003664PBS2YJL128CverifiedMAP kinase kinase that plays a pivotal role in the osmosensingsignal-transduction pathway, activated undersevere osmotic stress 0.006410.16913&radic S000004494RAD52YML032CverifiedProtein that stimulates strand exchange by facilitating Rad51pbinding to single-stranded DNA; annealscomplementary single-stranded DNA; involved inthe repair of double-strand breaks in DNAduring vegetative growth and meiosis 0.00640.16913 S000004828GAS3YMR215WverifiedPutative 1,3-beta-glucanosyltransferase, has similarity toGas1p; localizes to the cell wall 0.006390.16913&radic&radic S000002266KIN28YDL108WverifiedSerine/threonine protein kinase, subunit of the transcriptionfactor TFIIH; involved in transcriptioninitiation at RNA polymerase II promoters &radic0.006350.1685 S000002620TCP1YDR212WverifiedAlpha subunit of chaperonin-containing T-complex, whichmediates protein folding in the cytosol;involved in maintenance of actin cytoskeleton;homolog to Drosophila melanogaster and mousetailless complex polypeptide 0.006350.1685&radic&radic S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling 0.006310.16798&radic&radic S000004612YMR010WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1 0.006290.16738 S000005042RAS2YNL098CverifiedGTP-binding protein that regulates the nitrogen starvationresponse, sporulation, and filamentous growth;farnesylation and palmitoylation required foractivity and localization to plasma membrane;homolog of mammalian Ras proto-oncogenes 0.006310.16738 S000001913YFR017CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR017C is not an essential gene 0.006290.1666&radic&radic&radic S000002506BMH2YDR099Wverified14-3-3 protein, minor isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others 0.006290.1666&radic&radic&radic S000000241SCO1YBR037CverifiedCopper-binding protein of the mitochondrial inner membrane,required for cytochrome c oxidase activity andrespiration; may function to deliver copper tocytochrome c oxidase; has similarity tothioredoxins 0.006280.1666&radic S000004529TEM1YML064CverifiedGTP-binding protein of the ras superfamily involved intermination of M-phase; controls actomyosin andseptin dynamics during cytokinesis 0.006260.1666 S000006365SGV1YPR161CverifiedCyclin (Bur2p)-dependent protein kinase that functions intranscriptional regulation; phosphorylates thecarboxy-terminal domain of Rpo21p, which is thelargest subunit of RNA polymerase II; regulatedby Cak1p 0.006250.16627 S000004580CTK3YML112WverifiedGamma subunit of C-terminal domain kinase I (CTDK-I), whichphosphorylates the C-terminal repeated domainof the RNA polymerase II large subunit (Rpo21p)to affect both transcription and pre-mRNA 3'end processing 0.006220.16563 S000004785YMR173W-ADubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W 0.006220.16563&radic&radic&radic S000005887PDE2YOR360CverifiedHigh-affinity cyclic AMP phosphodiesterase, component of thecAMP-dependent protein kinase signaling system,protects the cell from extracellular cAMP,contains readthrough motif surroundingtermination codon 0.006180.16491&radic S000004240SSP120YLR250WverifiedProtein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to the cytoplasmin a punctate pattern 0.006150.16432&radic S000001890VTC2YFL004WverifiedVacuolar membrane protein involved in vacuolar polyphosphateaccumulation; functions as a regulator ofvacuolar H+-ATPase activity and vacuolartransporter chaperones; involved in proteinlocalization and non-autophagic vacuolar fusion 0.006150.16432&radic S000004470SPT5YML010WverifiedProtein that forms a complex with Spt4p and mediates bothactivation and inhibition of transcriptionelongation; Spt4p-Spt5p complex also plays arole in pre-mRNA processing 0.006150.16432&radic&radic S000002193GPR1YDL035CverifiedPlasma membrane G protein coupled receptor (GPCR) thatinteracts with the heterotrimeric G proteinalpha subunit, Gpa2p, and with Plc1p; sensorthat integrates nutritional signals with themodulation of cell fate via PKA and cAMPsynthesis 0.006170.16432&radic S000004926NIP1YMR309CverifiedSubunit of the eukaryotic translation initiation factor 3(eIF3), involved in the assembly ofpreinitiation complex and start codon selection 0.00610.16123&radic S000000362AMN1YBR158WverifiedProtein required for daughter cell separation, multiple mitoticcheckpoints, and chromosome stability; contains12 degenerate leucine-rich repeat motifs;expression is induced by the Mitotic ExitNetwork (MEN) 0.006090.16123&radic S000001443DJP1YIR004WverifiedCytosolic J-domain-containing protein, required for peroxisomalprotein import and involved in peroxisomeassembly, homologous to E. coli DnaJ 0.00610.16123&radic S000002782YDR374CUncharacterizedHypothetical protein 0.006080.16123&radic&radic S000000171SSA3YBL075CverifiedATPase involved in protein folding and the response to stress;plays a role in SRP-dependent cotranslationalprotein-membrane targeting and translocation;member of the heat shock protein 70 (HSP70)family; localized to the cytoplasm 0.006110.16123&radic&radic S000002685MTH1YDR277CverifiedNegative regulator of the glucose-sensing signal transductionpathway, required for repression oftranscription by Rgt1p; interacts with Rgt1pand the Snf3p and Rgt2p glucose sensors;phosphorylated by Yck1p, triggering Mth1pdegradation 0.006040.16123&radic S000000601SAT4YCR008WverifiedSer/Thr protein kinase involved in salt tolerance; funtions inregulation of Trk1p-Trk2p potassiumtransporter; partially redundant with Hal5p;has similarity to Npr1p 0.006030.16123&radic&radic S000001930PHO4YFR034CverifiedBasic helix-loop-helix (bHLH) transcription factor; bindscooperatively with Pho2p to the PHO5 promoter;function is regulated by phosphorylation atmultiple sites and by phosphate availability 0.006050.16123 S000005995YTA6YPL074WverifiedPutative ATPase of the CDC48/PAS1/SEC18 (AAA) family, localizedto the cortex of mother cells but not todaughter cells 0.00610.16123 S000006127YPL206CUncharacterizedProtein that plays a role in metabolism of glycerophosphocholine to phosphatidylcholine; contains glycerophosphodiester phosphodiesterase motifs 0.006120.16123 S000003324DBF2YGR092WverifiedSer/Thr kinase involved in transcription and stress response;functions as part of a network of genes in exitfrom mitosis; localization is cell cycleregulated; activated by Cdc15p during the exitfrom mitosis 0.006040.16123 S000001178SPL2YHR136CverifiedProtein with similarity to cyclin-dependent kinase inhibitors,overproduction suppresses a plc1 null mutation;green fluorescent protein (GFP)-fusion proteinlocalizes to the cytoplasm in a punctatepattern 0.006010.16099&radic S000004103HOG1YLR113WverifiedMitogen-activated protein kinase involved in osmoregulation viathree independent osmosensors; mediates therecruitment and activation of RNA Pol II atHot1p-dependent promoters; localizationregulated by Ptp2p and Ptp3p 0.006020.16099&radic&radic S000002175CDC7YDL017WverifiedDDK (Dbf4-dependent kinase) catalytic subunit required forfiring origins and replication fork progressionin mitosis through phosphorylation of Mcm2-7pcomplexes and Cdc45p; kinase activitycorrelates with cyclical DBF4 expression 0.005990.16031&radic S000002284CDC48YDL126CverifiedATPase in ER, nuclear membrane and cytosol with homology tomammalian p97; in a complex with Npl4p andUfd1p participates in retrotranslocation ofubiquitinated proteins from the ER into thecytosol for degradation by the proteasome 0.005990.16031 S000005925LSP1YPL004CverifiedPrimary component of eisosomes, which are large immobile patchstructures at the cell cortex associated withendocytosis, along with Pil1p and Sur7p ; nullmutants show activation of Pkc1p/Ypk1p stressresistance pathways &radic0.006010.16031 S000003567MAD2YJL030WverifiedComponent of the spindle-assembly checkpoint complex, whichdelays the onset of anaphase in cells withdefects in mitotic spindle assembly; forms acomplex with Mad1p 0.0060.16031&radic S000001750UTH1YKR042WverifiedMitochondrial outer membrane and cell wall localized SUN familymember required for mitochondrial autophagy;involved in the oxidative stress response, lifespan during starvation, mitochondrialbiogenesis, and cell death 0.005980.16025&radic S000002290CDC53YDL132WverifiedCullin, structural protein of SCF complexes (which also containSkp1p, Cdc34p, and an F-box protein) involvedin ubiquitination; SCF promotes the G1-Stransition by targeting G1 cyclins and theCln-CDK inhibitor Sic1p for degradation 0.005980.16025 S000004603CDC5YMR001CverifiedPolo-like kinase with similarity to Xenopus Plx1 and S. pombePlo1p; found at bud neck, nucleus and SPBs; hasmultiple functions in mitosis and cytokinesisthrough phosphorylation of substrates; may be aCdc28p substrate 0.005930.15814&radic S000002490RRP8YDR083WverifiedNucleolar protein involved in rRNA processing, pre-rRNAcleavage at site A2; also involved in telomeremaintenance; mutation is synthetically lethalwith a gar1 mutation 0.005930.15814&radic&radic S000006409YEL077CUncharacterizedHelicase-like protein encoded within the telomeric Y' element 0.005920.15814&radic&radic S000001669MTR2YKL186CverifiedmRNA transport regulator, essential nuclear protein; Mex67p andMtr2p form a mRNA export complex which binds toRNA 0.005920.15814&radic&radic&radic S000000399MSI1YBR195CverifiedSubunit of chromatin assembly factor I (CAF-I), regulates theRAS/cAMP pathway via sequestration of Npr1pkinase; localizes to the nucleus and cytoplasm;homologous to human retinoblastoma bindingproteins RbAp48 and RbAp46 0.005940.15814&radic&radic S000000340MEC1YBR136WverifiedGenome integrity checkpoint protein and PI kinase superfamilymember; signal transducer required for cellcycle arrest and transcriptional responsesprompted by damaged or unreplicated DNA;monitors and participates in meioticrecombination 0.00590.15814 S000005596GYP1YOR070CverifiedCis-golgi GTPase-activating protein (GAP) for the Rab familymembers Ypt1p (in vivo) and for Ypt1p, Sec4p,Ypt7p, and Ypt51p (in vitro); involved invesicle docking and fusion 0.00590.15796&radic S000004795SSO2YMR183CverifiedPlasma membrane t-SNARE involved in fusion of secretoryvesicles at the plasma membrane; syntaxinhomolog that is functionally redundant withSso1p 0.005890.15796 S000000457SRB6YBR253WverifiedEssentital subunit of the RNA polymerase II mediator complex;associates with core polymerase subunits toform the RNA polymerase II holoenzyme;essential for transcriptional regulation 0.005880.15792&radic&radic S000005299ACC1YNR016CverifiedAcetyl-CoA carboxylase, biotin containing enzyme that catalyzesthe carboxylation of acetyl-CoA to formmalonyl-CoA; required for de novo biosynthesisof long-chain fatty acids 0.005840.15678&radic S000005205ORC5YNL261WverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing 0.005840.15678&radic&radic S000000574VBA3YCL069WverifiedPermease of basic amino acids in the vacuolar membrane 0.005850.15678&radic&radic S000006156RVB2YPL235WverifiedEssential protein involved in transcription regulation;component of chromatin remodeling complexes;required for assembly and function of the INO80complex; member of the RUVB-like protein family 0.005820.15631&radic S000002348RBS1YDL189WverifiedProtein of unknown function, identified as a high copysuppressor of psk1 psk2 mutations that confertemperature-sensitivity for galactoseutilization; proposed to bind single-strandednucleic acids via its R3H domain 0.00580.15618 S000004550TUB1YML085CverifiedAlpha-tubulin; associates with beta-tubulin (Tub2p) to formtubulin dimer, which polymerizes to formmicrotubules 0.005790.15567 S000003466YHB1YGR234WverifiedNitric oxide oxidoreductase, flavohemoglobin involved in nitricoxide detoxification; plays a role in theoxidative and nitrosative stress responses 0.005790.15567&radic&radic S000000657YCR061WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.005790.15567 S000006045SPC29YPL124WverifiedInner plaque spindle pole body (SPB) component, links thecentral plaque component Spc42p to the innerplaque component Spc110p; required for SPBduplication 0.005780.15567&radic&radic S000006268YPR064WDubiousHypothetical protein 0.005780.15445 S000005062DCP2YNL118CverifiedCatalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex,which removes the 5' cap structure from mRNAsprior to their degradation; member of the Nudixhydrolase family 0.005760.15445 S000002257BUG1YDL099WuncharacterizedProtein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to the cytoplasmin a punctate pattern 0.005770.15445 S000003957RIX7YLL034CverifiedPutative ATPase of the AAA family, required for export ofpre-ribosomal large subunits from the nucleus;distributed between the nucleolus, nucleoplasm,and nuclear periphery depending on growthconditions 0.005780.15445&radic S000004976HHT2YNL031CverifiedOne of two identical histone H3 proteins (see also HHT1); corehistone required for chromatin assembly,involved in heterochromatin-mediated telomericand HM silencing; regulated by acetylation,methylation, and mitotic phosphorylation 0.005780.15445 S000000201PKC1YBL105CverifiedProtein serine/threonine kinase essential for cell wallremodeling during growth; localized to sites ofpolarized growth and the mother-daughter budneck; homolog of the alpha, beta, and gammaisoforms of mammalian protein kinase C (PKC) 0.005750.15445 S000006036BEM3YPL115CverifiedRho GTPase activating protein (RhoGAP) involved in control ofthe cytoskeleton organization; targets theessential Rho-GTPase Cdc42p, which controlsestablishment and maintenance of cell polarity,including bud-site assembly 0.005750.15445&radic S000004656FAR3YMR052WverifiedProtein involved in G1 cell cycle arrest in response topheromone, in a pathway different from theFar1p-dependent pathway; interacts with Far7p,Far8p, Far9p, Far10p, and Far11p 0.005770.15445 S000002678CCC2YDR270WverifiedCu(+2)-transporting P-type ATPase, required for export ofcopper from the cytosol into an extracytosoliccompartment; has similarity to human proteinsinvolved in Menkes and Wilsons diseases 0.005730.15435&radic&radic S000001149CDC12YHR107CverifiedComponent of the septin ring of the mother-bud neck that isrequired for cytokinesis; septins recruitproteins to the neck and can act as a barrierto diffusion at the membrane, and they comprisethe 10nm filaments seen with EM 0.005720.15421&radic S000000521DCC1YCL016CverifiedSubunit of a complex with Ctf8p and Ctf18p that shares somecomponents with Replication Factor C, requiredfor sister chromatid cohesion and telomerelength maintenance 0.005710.15383&radic&radic S000000412DUR1,2YBR208CverifiedUrea amidolyase, contains both urea carboxylase and allophanatehydrolase activities, degrades urea to CO2 andNH3; expression sensitive to nitrogencatabolite repression and induced byallophanate, an intermediate in allantoindegradation 0.00570.15364&radic&radic&radic S000002886SNM1YDR478WverifiedSubunit of RNase MRP, which cleaves pre-rRNA; not sharedbetween Rnase MRP and nuclear Rnase P, incontrast to all other Rnase MRP proteinsubunits; binds to the NME1 RNA subunit ofRnase MRP 0.005710.15364&radic S000000575YCL073CUncharacterizedProtein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YKR106W 0.005690.15334&radic S000001525SPC42YKL042WverifiedCentral plaque component of spindle pole body (SPB); involvedin SPB duplication, may facilitate attachmentof the SPB to the nuclear membrane 0.005690.15334&radic S000005969CAM1YPL048WverifiedHomolog of translational cofactor elongation factor-1 gamma,participates in the regulation of GTP-bindingprotein EF-1 alpha, may play a redundant rolein the regulation of protein synthesis oranother GTP-dependent process 0.005680.1528 S000006279OPY2YPR075CverifiedIntegral membrane protein that functions in the signalingbranch of the high-osmolarity glycerol (HOG)pathway; interacts with Ste50p; overproductionblocks cell cycle arrest in the presence ofmating pheromone 0.005670.1528&radic S000001885CDC4YFL009WverifiedF-box protein required for G1/S and G2/M transition, associateswith Skp1p and Cdc53p to form a complex,SCFCdc4, which acts as ubiquitin-protein ligasedirecting ubiquitination of the phosphorylatedCDK inhibitor Sic1p 0.005690.1528&radic S000005499CDC33YOL139CverifiedCytoplasmic mRNA cap binding protein; the eIF4E-cap complex isresponsible for mediating cap-dependent mRNAtranslation via interactions with thetranslation initiation factor eIF4G (Tif4631por Tif4632p) 0.005670.1528 S000000099HTA2YBL003CverifiedOne of two nearly identical (see also HTA1) histone H2Asubtypes; core histone required for chromatinassembly and chromosome function; DNAdamage-dependent phosphorylation by Mec1pfacilitates DNA repair; acetylated by Nat4p 0.005680.1528&radic&radic&radic S000003854IME1YJR094CverifiedMaster regulator of meiosis that is active only during meioticevents, activates transcription of earlymeiotic genes through interaction with Ume6p,degraded by the 26S proteasome followingphosphorylation by Ime2p 0.005680.1528&radic S000002575CDC37YDR168WverifiedEssential Hsp90p co-chaperone; necessary for passage throughthe START phase of the cell cycle 0.005670.1528&radic&radic S000002249UBX3YDL091CuncharacterizedUBX (ubiquitin regulatory X) domain-containing protein thatinteracts with Cdc48p, green fluorescentprotein (GFP)-fusion protein localizes to thecytoplasm in a punctate pattern 0.005680.1528&radic S000000823RPN3YER021WverifiedEssential, non-ATPase regulatory subunit of the 26S proteasomelid, similar to the p58 subunit of the human26S proteasome; temperature-sensitive allelescause metaphase arrest, suggesting a role forthe proteasome in cell cycle control 0.005670.1528 S000003412RNR4YGR180CverifiedRibonucleotide-diphosphate reductase (RNR), small subunit; theRNR complex catalyzes the rate-limiting step indNTP synthesis and is regulated by DNAreplication and DNA damage checkpoint pathwaysvia localization of the small subunits 0.005660.15272&radic&radic&radic S000001865CAK1YFL029CverifiedCyclin-dependent kinase-activating kinase required for passagethrough the cell cycle, phosphorylates andactivates Cdc28p; nucleotide-binding pocketdiffers significantly from those of most otherprotein kinases &radic0.00560.15084&radic S000001314RPL34BYIL052CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl34Ap and has similarity to ratL34 ribosomal protein 0.005650.15084&radic S000002381FMP45YDL222CverifiedIntegral membrane protein localized to mitochondria (untaggedprotein) and eisosomes, immobile patches at thecortex associated with endocytosis; sporulationand sphingolipid content are altered inmutants; has homologs SUR7 and YNL194C 0.005650.15084 S000001595ABF1YKL112WverifiedDNA binding protein with possible chromatin-reorganizingactivity involved in transcriptionalactivation, gene silencing, and DNA replicationand repair 0.005650.15084&radic&radic S000001384POG1YIL122WverifiedPutative transcriptional activator that promotes recovery frompheromone induced arrest; inhibits bothalpha-factor induced G1 arrest and repressionof CLN1 and CLN2 via SCB/MCB promoter elements;potential Cdc28p substrate; SBF regulated 0.005610.15084 S000001796TVP38YKR088CuncharacterizedIntegral membrane protein localized to late Golgi vesiclesalong with the v-SNARE Tlg2p; green fluorescentprotein (GFP)-fusion protein localizes to thecytoplasm in a punctate pattern 0.005610.15084 S000004685NAM7YMR080CverifiedATP-dependent RNA helicase of the SFI superfamily, required fornonsense mediated mRNA decay and for efficienttranslation termination at nonsense codons;involved in telomere maintenance 0.005650.15084 S000000113PEP1YBL017CverifiedType I transmembrane sorting receptor for multiple vacuolarhydrolases; cycles between the late-Golgi andprevacuolar endosome-like compartments 0.005620.15084&radic&radic S000005897MRS6YOR370CverifiedRab escort protein, forms a complex with the Ras-like smallGTPase Ypt1p that is required for theprenylation of Ypt1p by proteingeranylgeranyltransferase type II (Bet2p-Bet4p) 0.005610.15084&radic&radic S000005967ELC1YPL046CverifiedElongin C, forms heterodimer with Ela1p that participates intranscription elongation; expressiondramatically upregulated during sporulation;widely conserved among eukaryotes 0.005620.15084&radic S000002483RAD55YDR076WverifiedProtein that stimulates strand exchange by stabilizing thebinding of Rad51p to single-stranded DNA;involved in the recombinational repair ofdouble-strand breaks in DNA during vegetativegrowth and meiosis; forms heterodimer withRad57p 0.005620.15084&radic&radic S000004930TGL3YMR313CverifiedTriacylglycerol lipase of the lipid particle, responsible forall the TAG lipase activity of the lipidparticle; contains the consensus sequence motifGXSXG, which is found in lipolytic enzymes 0.005590.15009 S000000741EDC3YEL015WverifiedNon-essential conserved protein of unknown function, plays arole in mRNA decapping by specificallyaffecting the function of the decapping enzymeDcp1p; localizes to cytoplasmic mRNA processingbodies 0.005570.15009&radic S000003493APL6YGR261CverifiedBeta3-like subunit of the yeast AP-3 complex; functions intransport of alkaline phosphatase to thevacuole via the alternate pathway; exists inboth cytosolic and peripherally associatedmembrane-bound pools 0.005570.15009 S000004330OPI9YLR338WdubiousDubious open reading frame unlikely to encode a protein, basedon available experimental and comparativesequence data; partially overlaps the verifiedORF VRP1/YLR337C 0.005580.15009&radic&radic S000005405PSK2YOL045WverifiedOne of two (see also PSK1) PAS domain containing S/T proteinkinases; regulates sugar flux and translationin response to an unknown metabolite byphosphorylating Ugp1p and Gsy2p (sugar flux)and Caf20p, Tif11p and Sro9p (translation) 0.005570.14999&radic&radic S000003181SKI8YGL213CverifiedProtein involved in exosome mediated 3' to 5' mRNA degradationand translation inhibition of non-poly(A) mRNAsas well as double-strand break formation duringmeiotic recombination; required for repressingpropagation of dsRNA viruses 0.005560.1499&radic S000004255NEJ1YLR265CverifiedProtein involved in regulation of nonhomologous end joining;repressed by MAT heterozygosity; associateswith Lif1p and regulates its cellulardistribution 0.005550.14955&radic S000002332YDL173WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDL173W is not an essential gene 0.005530.14922&radic S000001628RPT1YKL145WverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; required for optimalCDC20 transcription; interacts with Rpn12p andthe E3 ubiquitin-protein ligase Ubr1p 0.005530.14922&radic&radic S000001877GNA1YFL017CverifiedEvolutionarily conserved glucosamine-6-phosphateacetyltransferase required for multiple cellcycle events including passage through START,DNA synthesis, and mitosis; involved inUDP-N-acetylglucosamine synthesis, formsGlcNAc6P from AcCoA 0.005530.14922&radic&radic&radic S000004238RCK2YLR248WverifiedProtein kinase involved in the response to oxidative andosmotic stress; identified as suppressor of S.pombe cell cycle checkpoint mutations 0.005510.1479&radic S000000895TSC11YER093CverifiedSubunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), amembrane-associated complex that regulatesactin cytoskeletal dynamics during polarizedgrowth and cell wall integrity; involved insphingolipid metabolism; contains a RasGEFNdomain 0.005490.1479 S000006188ACM1YPL267WverifiedCell cycle regulated protein of unknown function; associatedwith Cdh1p and may supress theAPC/C[Cdh1]-mediated proteolysis of mitoticcyclins 0.00550.1479&radic S000004782YMR172C-ADubiousHypothetical protein 0.005520.1479&radic&radic&radic S000005635INP53YOR109WverifiedPhosphatidylinositol 4,5-bisphosphate 5-phosphatase,synaptojanin-like protein with an N-terminalSac1 domain, plays a role in a TGN (trans Golginetwork)-to-early endosome pathway;hyperosmotic stress causes translocation toactin patches 0.005490.1479 S000001571YKL088WUncharacterizedPredicted phosphopantothenoylcysteine decarboxylase, may be involved in coenzyme A biosynthesis; interacts with Sis2p and Vhs3p 0.005510.1479&radic S000003124AMS1YGL156WverifiedVacuolar alpha mannosidase, involved in free oligosaccharide(fOS) degradation; delivered to the vacuole ina novel pathway separate from the secretorypathway 0.005510.1479 S000003273BUD9YGR041WverifiedProtein involved in bud-site selection; diploid mutants displaya unipolar budding pattern instead of thewild-type bipolar pattern, and bud at thedistal pole 0.005520.1479&radic S000005719PEX27YOR193WverifiedPeripheral peroxisomal membrane protein involved in controllingperoxisome size and number, interacts withhomologous protein Pex25p 0.00550.1479&radic S000005888PRT1YOR361CverifiedSubunit of the core complex of translation initiation factor3(eIF3), essential for translation; part of asubcomplex (Prt1p-Rpg1p-Nip1p) that stimulatesbinding of mRNA and tRNA(i)Met to ribosomes 0.005480.14787&radic S000001586LAP4YKL103CverifiedVacuolar aminopeptidase, often used as a marker protein instudies of autophagy and cytosol to vacuoletargeting (CVT) pathway 0.005470.14757&radic&radic&radic S000000814PRE1YER012Wverified20S proteasome beta-type subunit; localizes to the nucleusthroughout the cell cycle 0.005460.14757&radic S000006253ATG11YPR049CverifiedPeripheral membrane protein required for delivery ofaminopeptidase I (Lap4p) to the vacuole in thecytoplasm-to-vacuole targeting pathway; alsorequired for peroxisomal degradation(pexophagy) 0.005410.14592 S000005986VPS28YPL065WverifiedComponent of the ESCRT-I complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; involved in transport ofprecursors for soluble vacuolar hydrolases fromthe late endosome to the vacuole 0.00540.14592 S000003487COQ6YGR255CverifiedPutative flavin-dependent monooxygenase, involved in ubiquinone(Coenzyme Q) biosynthesis; located on thematrix side of the mitochondrial inner membrane 0.005430.14592 S000003507RTT102YGR275WverifiedComponent of both the SWI/SNF and RSC chromatin remodelingcomplexes, suggested role in chromosomemaintenance; possible weak regulator of Ty1transposition 0.00540.14592&radic&radic&radic S000002299RPO21YDL140CverifiedRNA polymerase II largest subunit B220, part of central core;phosphorylation of C-terminal heptapeptiderepeat domain regulates association withtranscription and splicing factors; similar tobacterial beta-prime 0.005420.14592 S000002259DUN1YDL101CverifiedCell-cycle checkpoint serine-threonine kinase required for DNAdamage-induced transcription of certain targetgenes, phosphorylation of Rad55p and Sml1p, andtransient G2/M arrest after DNA damage; alsoregulates postreplicative DNA repair 0.00540.14592&radic&radic S000005074CPT1YNL130CverifiedCholinephosphotransferase, required for phosphatidylcholinebiosynthesis and for inositol-dependentregulation of EPT1 transcription 0.005450.14592 S000005364SIN3YOL004WverifiedComponent of the Sin3p-Rpd3p histone deacetylase complex,involved in transcriptional repression andactivation of diverse processes, includingmating-type switching and meiosis; involved inthe maintenance of chromosomal integrity 0.005410.14592&radic S000004846YMR233WUncharacterizedProtein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; YMR233W is not an essential gene 0.005430.14592&radic S000005407YOL047CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.005430.14592&radic&radic S000006111NAB3YPL190CverifiedSingle stranded DNA binding protein; acidic ribonucleoprotein;required for termination of non-poly(A)transcripts and efficient splicing; interactswith Nrd1p 0.005390.14568&radic&radic S000004672AVO2YMR068WverifiedComponent of a complex containing the Tor2p kinase and otherproteins, which may have a role in regulationof cell growth 0.005390.14568 S000002447ENA1YDR040CverifiedP-type ATPase sodium pump, involved in Na+ and Li+ efflux toallow salt tolerance 0.005370.14519 S000002510STE5YDR103WverifiedPheromone-responsive scaffold protein; shuttles from thenucleus to the plasma membrane and assembleskinases Ste11p, Ste7p, and Fus3p into aspecific signaling complex; active oligomericform interacts with Ste4p-Ste18p complex 0.005370.14519&radic S000001209CDC23YHR166CverifiedSubunit of the anaphase-promoting complex/cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 0.005380.14519 S000005185ZWF1YNL241CverifiedGlucose-6-phosphate dehydrogenase (G6PD), catalyzes the firststep of the pentose phosphate pathway; involvedin adapting to oxidatve stress; homolog of thehuman G6PD which is deficient in patients withhemolytic anemia 0.005380.14519&radic&radic S000005028END3YNL084CverifiedEH domain-containing protein involved in endocytosis, actincytoskeletal organization and cell wallmorphogenesis; forms a complex with Sla1p andPan1p 0.005360.14468 S000003850GRR1YJR090CverifiedF-box protein component of the SCF ubiquitin-ligase complex,required for Cln1p and Cln2p degradation;involved in carbon catabolite repression,glucose-dependent divalent cation transport,high-affinity glucose transport, andmorphogenesis 0.005360.14468 S000002630YDR222WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.005370.14468&radic S000004594PGA3YML125CuncharacterizedEssential protein required for maturation of Gas1p and Pho8p,protein trafficking; GFP-fusion proteinlocalizes to the endoplasmic reticulum; nullmutants have a cell separation defect 0.005350.14468&radic S000004923FKS3YMR306WverifiedProtein of unknown function, has similarity to1,3-beta-D-glucan synthase catalytic subunitsFks1p and Gsc2p; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.005350.14468&radic S000004618SOK2YMR016CverifiedNuclear protein that plays a regulatory role in the cyclic AMP(cAMP)-dependent protein kinase (PKA) signaltransduction pathway; negatively regulatespseudohyphal differentiation; homologous toseveral transcription factors 0.005350.14468 S000006389ATG13YPR185WverifiedPhosphorylated protein that interacts with Vac8p, required forthe cytoplasm-to-vacuole targeting (Cvt)pathway and autophagy 0.005360.14468 S000002382HBT1YDL223CverifiedSubstrate of the Hub1p ubiquitin-like protein that localizes tothe shmoo tip (mating projection); mutants aredefective for mating projection formation,thereby implicating Hbt1p in polarized cellmorphogenesis 0.005340.14409&radic S000004783HOT1YMR172WverifiedTranscription factor required for the transient induction ofglycerol biosynthetic genes GPD1 and GPP2 inresponse to high osmolarity; targets Hog1p toosmostress responsive promoters; has similarityto Msn1p and Gcr1p 0.005340.14409&radic S000001770TFA2YKR062WverifiedTFIIE small subunit, involved in RNA polymerase IItranscription initiation 0.005330.14409 S000001673CNB1YKL190WverifiedCalcineurin B; the regulatory subunit of calcineurin, aCa++/calmodulin-regulated protein phosphatasewhich regulates Crz1p (a stress-responsetranscription factor), the other calcineurinsubunit is encoded by CNA1 and/or CMP1 0.005330.14409&radic S000001047GPA1YHR005CverifiedGTP-binding alpha subunit of the heterotrimeric G protein thatcouples to pheromone receptors; negativelyregulates the mating pathway by sequesteringG(beta)gamma and by triggering an adaptiveresponse; activates Vps34p at the endosome 0.005350.14409 S000006337SPN1YPR133CverifiedProtein that interacts with Spt6p and copurifies with Spt5p andRNA polymerase II, probable transcriptionalelongation factor; metazoan homologs contain anacidic N terminus; mutations in the gene conferan Spt- phenotype 0.00530.14322&radic S000000089YAR064WUncharacterizedPutative protein of unknown function 0.005320.14322&radic S000006078TGS1YPL157WverifiedTrimethyl guanosine synthase, conserved nucleolar methyltransferase responsible for conversion of them(7)G cap structure of snRNAs and snoRNAs tom(2,2,7)G; also required for ribosome synthesisand nucleolar morphology 0.005310.14322&radic&radic S000005265YNL321WUncharacterizedProtein of unknown function, potential Cdc28p substrate 0.005320.14322&radic S000001046NEM1YHR004CverifiedProtein of the nuclear envelope required for the sphericalshape of the nucleus; required for normalsporulation 0.005320.14322 S000004444SST2YLR452CverifiedGTPase-activating protein for Gpa1p, regulates desensitizationto alpha factor pheromone; also required toprevent receptor-independent signaling of themating pathway; member of the RGS (regulator ofG-protein signaling) family 0.00530.14322 S000000075UIP3YAR027WverifiedPutative integral membrane protein of unknown function;interacts with Ulp1p at the nuclear periphery;member of DUP240 gene family 0.00530.14305 S000003827TOR1YJR066WverifiedPIK-related protein kinase and rapamycin target; subunit ofTORC1, a complex that controls growth inresponse to nutrients by regulatingtranslation, transcription, ribosomebiogenesis, nutrient transport and autophagy;involved in meiosis 0.00530.14305 S000004849TAF9YMR236WverifiedSubunit (17 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification, similar to histone H3 0.00530.14305&radic&radic S000004279MEC3YLR288CverifiedDNA damage and meiotic pachytene checkpoint protein; subunit ofa heterotrimeric complex (Rad17p-Mec3p-Ddc1p)that forms a sliding clamp, loaded onto partialduplex DNA by a clamp loader complex; homologof human and S. pombe Hus1 0.005280.14244&radic S000003168EMP24YGL200CverifiedIntegral membrane component of endoplasmic reticulum-derivedCOPII-coated vesicles, which function in ER toGolgi transport 0.005280.14244 S000001505CDC16YKL022CverifiedSubunit of the anaphase-promoting complex/cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition; required forsporulation 0.005280.14244 S000002775YDR367WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.005260.14218&radic S000004172SWI6YLR182WverifiedTranscription cofactor, forms complexes with DNA-bindingproteins Swi4p and Mbp1p to regulatetranscription at the G1/S transition; involvedin meiotic gene expression; localizationregulated by phosphorylation; potential Cdc28psubstrate 0.005270.14218&radic S000002429CIS1YDR022CverifiedProtein of unknown function that may be involved in microtubuleorganization; high-copy suppressor of CIK1deletion 0.005250.14178 S000006353NCE102YPR149WverifiedProtein of unknown function; contains transmembrane domains;involved in secretion of proteins that lackclassical secretory signal sequences; componentof the detergent-insoluble glycolipid-enrichedcomplexes (DIGs) 0.005240.14178&radic S000000492APM3YBR288CverifiedMu3-like subunit of the clathrin associated protein complex(AP-3); functions in transport of alkalinephosphatase to the vacuole via the alternatepathway 0.005240.14162 S000004189YLR199CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR199C is not an essential gene; ORF contains an intron 0.005210.14086&radic&radic S000000766UTR2YEL040WverifiedPutative glycosidase, glycosylphosphatidylinositol(GPI)-anchored protein localized to the budneck; has a role in cell wall maintenance 0.00520.14033&radic&radic S000002608VPS64YDR200CverifiedCytoplasmic protein required for cytoplasm to vacuole targetingof proteins; forms a complex with Far3p, Far7p,Far10p, and Far11p that is involved inpheromone-induced cell cycle arrest; alsolocalized to the endoplasmic reticulum membrane 0.00520.14033&radic&radic S000005943RAD1YPL022WverifiedSingle-stranded DNA endonuclease (with Rad10p), cleavessingle-stranded DNA during nucleotide excisionrepair and double-strand break repair; subunitof Nucleotide Excision Repair Factor 1 (NEF1);homolog of human XPF protein 0.00520.14033 S000002903VPS3YDR495CverifiedCytoplasmic protein required for the sorting and processing ofsoluble vacuolar proteins, acidification of thevacuolar lumen, and assembly of the vacuolarH+-ATPase 0.00520.14033 S000003221RTG2YGL252CverifiedSensor of mitochondrial dysfunction; regulates the subcellularlocation of Rtg1p and Rtg3p, transcriptionalactivators of the retrograde (RTG) and TORpathways; Rtg2p is inhibited by thephosphorylated form of Mks1p 0.005170.13984&radic S000001229KOG1YHR186CverifiedSubunit of TORC1, a rapamycin-sensitive complex involved ingrowth control that contains Tor1p or Tor2p,Lst8p and Tco89p; contains four HEAT repeatsand seven WD-40 repeats; may act as a scaffoldprotein to couple TOR and its effectors 0.005170.13984&radic S000000305FES1YBR101CverifiedHsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog ofSil1p, which is the nucleotide exchange factorfor BiP (Kar2p) in the endoplasmic reticulum 0.005180.13984 S000004410CDC73YLR418CverifiedConstituent of Paf1 complex with RNA polymerase II, Paf1p,Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinctfrom Srb-containing Pol II complexes; requiredfor expression of certain genes, modificationof some histones, and telomere maintenance 0.005180.13984&radic S000001271FAA3YIL009WverifiedLong chain fatty acyl-CoA synthetase, has a preference for C16and C18 fatty acids; green fluorescent protein(GFP)-fusion protein localizes to the cellperiphery 0.005170.13968&radic S000005070SPC98YNL126WverifiedComponent of the microtubule-nucleating Tub4p (gamma-tubulin)complex; interacts with Spc110p at the spindlepole body (SPB) inner plaque and with Spc72p atthe SPB outer plaque 0.005160.13968 S000001906UBP6YFR010WverifiedUbiquitin-specific protease situated in the base subcomplex ofthe 26S proteasome, releases free ubiquitinfrom branched polyubiquitin chains; deletioncauses hypersensitivity to cycloheximide andother toxic compounds 0.005160.13968&radic S000000559SPB1YCL054WverifiedAdoMet-dependent methyltransferase involved in rRNA processingand 60S ribosomal subunit maturation;methylates G2922 in the tRNA docking site ofthe large subunit rRNA and in the absence ofsnR52, U2921; suppressor of PAB1 mutants 0.005150.13915&radic S000004516SUR7YML052WverifiedPutative integral membrane protein; component of eisosomes;associated with endocytosis, along with Pil1pand Lsp1p; sporulation and plasma membranesphingolipid content are altered in mutants 0.005160.13915 S000005898GPB1YOR371CverifiedProposed beta subunit of the heterotrimeric G protein;interacts with the receptor Grp1p, affectssignaling by altering the level ofphosphorylation of PKS substrates; regulatespseudohyphal growth through cAMP levels;homolog of Gpb2p &radic0.005140.13915&radic&radic&radic S000004871YMR258CUncharacterizedProtein of unknown function with similarity to F-box proteins; physically interacts with Skp1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR258C is not an essential gene 0.005150.13915&radic&radic S000003171KEX1YGL203CverifiedProtease involved in the processing of killer toxin and alphafactor precursor; cleaves Lys and Arg residuesfrom the C-terminus of peptides and proteins 0.005140.13907&radic S000005742RUD3YOR216CverifiedGolgi matrix protein involved in the structural organization ofthe cis-Golgi; interacts genetically with COG3and USO1 0.005140.13907 S000004282GCD7YLR291CverifiedBeta subunit of the translation initiation factor eIF2B, theguanine-nucleotide exchange factor for eIF2;activity subsequently regulated byphosphorylated eIF2; first identified as anegative regulator of GCN4 expression 0.005120.13718&radic&radic S000002187ARP2YDL029WverifiedEssential component of the Arp2/3 complex, which is a highlyconserved actin nucleation center required forthe motility and integrity of actin patches;involved in endocytosis and membrane growth andpolarity 0.005120.13718 S000002625RAD9YDR217CverifiedDNA damage-dependent checkpoint protein, required forcell-cycle arrest in G1/S, intra-S, and G2/M;transmits checkpoint signal by activatingRad53p and Chk1p; hyperphosphorylated by Mec1pand Tel1p; potential Cdc28p substrate 0.005120.13718&radic&radic S000006204YRF1-7YPL283CverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p 0.005080.13718&radic S000001161SET1YHR119WverifiedHistone methyltransferase, subunit of the COMPASS (Set1C)complex which methylates histone H3 on lysine4; required in transcriptional silencing neartelomeres and at the silent mating type loci;contains a SET domain 0.005080.13718 S000005133SRP1YNL189WverifiedKaryopherin alpha homolog, forms a dimer with karyopherin betaKap95p to mediate import of nuclear proteins,binds the nuclear localization signal of thesubstrate during import; may also play a rolein regulation of protein degradation 0.005080.13718&radic&radic S000000104HIR1YBL008WverifiedNon-essential transcriptional corepressor involved in the cellcycle-regulated transcription of histone H2A,H2B, H3 and H4 genes; contributes to nucleosomeformation, heterochromatic gene silencing, andformation of functional kinetochores 0.005110.13718&radic&radic S000005314SSK2YNR031CverifiedMAP kinase kinase kinase of the HOG1 mitogen-activatedsignaling pathway; interacts with Ssk1p,leading to autophosphorylation and activationof Ssk2p which phosphorylates Pbs2p; alsomediates actin cytoskeleton recovery fromosmotic stress 0.00510.13718 S000005438AVO1YOL078WverifiedComponent of a membrane-bound complex containing the Tor2pkinase and other proteins, which may have arole in regulation of cell growth 0.005130.13718 S000005931RET3YPL010WverifiedZeta subunit of the coatomer complex (COPI), which coatsGolgi-derived transport vesicles; involved inretrograde transport between Golgi and ER 0.005080.13718&radic S000001694TRP3YKL211CverifiedBifunctional enzyme exhibiting both indole-3-glycerol-phosphatesynthase and anthranilate synthase activities,forms multifunctional hetero-oligomericanthranilate synthase:indole-3-glycerolphosphate synthase enzyme complex with Trp2p 0.005090.13718&radic S000006233APL4YPR029CverifiedGamma-adaptin, large subunit of the clathrin-associated protein(AP-1) complex; binds clathrin; involved invesicle mediated transport 0.005120.13718 S000004893CAT8YMR280CverifiedZinc cluster transcriptional activator necessary forderepression of a variety of genes undernon-fermentative growth conditions, activeafter diauxic shift, binds carbon sourceresponsive elements 0.00510.13718 S000002753HXT3YDR345CverifiedLow affinity glucose transporter of the major facilitatorsuperfamily, expression is induced in low orhigh glucose conditions 0.005060.13667 S000005653RGA1YOR127WverifiedGTPase-activating protein for the polarity-establishmentprotein Cdc42p; implicated in control of septinorganization, pheromone response, and haploidinvasive growth 0.005060.13667 S000004624QRI8YMR022WverifiedUbiquitin conjugating enzyme, involved in the ER-associatedprotein degradation pathway; requires Cue1p forrecruitment to the ER membrane; proposed to beinvolved in chromatin assembly 0.005060.13667&radic S000002796RVS167YDR388WverifiedActin-associated protein, subunit of a complex(Rvs161p-Rvs167p) involved in regulation ofactin cytoskeleton, endocytosis, and viabilityfollowing starvation or osmotic stress; homologof mammalian amphiphysin 0.005060.13667&radic&radic S000003696YJL160CUncharacterizedPutative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis 0.005070.13667&radic&radic&radic S000002576STB3YDR169CverifiedProtein that binds Sin3p in a two-hybrid assay 0.005060.13667&radic S000000287TEC1YBR083WverifiedTranscription factor required for full Ty1 epxression,Ty1-mediated gene activation, and haploidinvasive and diploid pseudohyphal growth;TEA/ATTS DNA-binding domain family member 0.005070.13667 S000001591SLD2YKL108WverifiedProtein required for DNA replication, phosphorylated in S phaseby S-phase cyclin-dependent kinases (Cdks),phosphorylation is essential for DNAreplication and for complex formation withDpb11p; potential Cdc28p substrate 0.005080.13667&radic&radic S000000822GPA2YER020WverifiedNucleotide binding alpha subunit of the heterotrimeric Gprotein that interacts with the receptor Gpr1p,has signaling role in response to nutrients;green fluorescent protein (GFP)-fusion proteinlocalizes to the cell periphery 0.005050.13624 S000003322UTP22YGR090WuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.005040.13624&radic&radic S000005166SSU72YNL222WverifiedTranscription/RNA-processing factor that associates with TFIIBand cleavage/polyadenylation factor Pta1p;exhibits phosphatase activity on serine-5 ofthe RNA polymerase II C-terminal domain;affects start site selection in vivo 0.005020.13534&radic&radic S000006074RAD53YPL153CverifiedProtein kinase, required for cell-cycle arrest in response toDNA damage; activated by transautophosphorylation when interacting withhyperphosphorylated Rad9p; also interacts withARS1 and plays a role in initiation of DNAreplication 0.005020.13534 S000004329VRP1YLR337CverifiedProline-rich actin-associated protein involved in cytoskeletalorganization and cytokinesis; related tomammalian Wiskott-Aldrich syndrome protein(WASP)-interacting protein (WIP) 0.005030.13534&radic S000001521RGT1YKL038WverifiedGlucose-responsive transcription factor that regulatesexpression of several glucose transporter (HXT)genes in response to glucose; binds topromoters and acts both as a transcriptionalactivator and repressor 0.005020.13534&radic S000005258DAL82YNL314WverifiedPositive regulator of allophanate inducible genes; binds adodecanucleotide sequence upstream of all genesthat are induced by allophanate; contains anUISALL DNA-binding, a transcriptionalactivation, and a coiled-coil domain 0.005030.13534&radic&radic S000004600YML131WUncharacterizedPutative protein of unknown function with similarity to oxidoreductases; mRNA expression is increased in a HOG1 and SKO1-dependent manner after osmotic shock; GFP-fusion protein localizes to the cytoplasm; YML131W is not an essential gene 0.005020.13534&radic S000000049FLC2YAL053WverifiedPutative FAD transporter; required for uptake of FAD intoendoplasmic reticulum; involved in cell wallmaintenance 0.005010.13511&radic S000003006OCH1YGL038CverifiedMannosyltransferase of the cis-Golgi apparatus, initiates thepolymannose outer chain elongation of N-linkedoligosaccharides of glycoproteins 0.005010.13511&radic&radic S000000731VAB2YEL005CverifiedProtein with a potential role in vacuolar function, assuggested by its ability to bind Vac8p; greenfluorescent protein (GFP)-fusion proteinlocalizes to the cytoplasm in a punctatepattern 0.005010.13511&radic S000003700TPK1YJL164CverifiedSubunit of cytoplasmic cAMP-dependent protein kinase, whichcontains redundant catalytic subunits Tpk1p,Tpk2p, and Tpk3p and regulatory subunit Bcy1p;promotes vegetative growth in response tonutrients; inhibits filamentous growth 0.005010.13511&radic&radic S000002434VPS54YDR027CverifiedComponent of the GARP (Golgi-associated retrograde protein)complex, Vps51p-Vps52p-Vps53p-Vps54p, which isrequired for the recycling of proteins fromendosomes to the late Golgi; potentiallyphosphorylated by Cdc28p 0.0050.13433 S000001709VPS1YKR001CverifiedGTPase required for vacuolar protein sorting, functions inactin cytoskeleton organization via itsinteraction with Sla1p; required for lateGolgi-retention of some proteins includingKex2p; involved in regulating peroxisomebiogenesis 0.004990.13433&radic&radic S000004874TPS3YMR261CverifiedRegulatory subunit of trehalose-6-phosphatesynthase/phosphatase complex, which synthesizesthe storage carbohydrate trehalose; expressionis induced by stress conditions and repressedby the Ras-cAMP pathway 0.004980.13433&radic&radic&radic S000005970DIG1YPL049CverifiedRegulatory protein of unknown function,constitutively-expressed, involved in theregulation of mating-specific genes and theinvasive growth pathway, required forMAP-kinase imposed repression, inhibitspheromone-responsive transcription 0.004980.13433 S000003561APS3YJL024CverifiedSmall subunit of the clathrin-associated adaptor complex AP-3,which is involved in vacuolar protein sorting;related to the sigma subunit of the mammalianclathrin AP-3 complex; suppressor of loss ofcasein kinase 1 function 0.0050.13433 S000005996GCR1YPL075WverifiedTranscriptional activator of genes involved in glycolysis;DNA-binding protein that interacts andfunctions with the transcriptional activatorGcr2p 0.004980.13433 S000002837TIF35YDR429CverifiedSubunit of the core complex of translation initiation factor3(eIF3), which is essential for translation 0.0050.13433&radic&radic&radic S000003927ORC3YLL004WverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing 0.0050.13433&radic&radic S000005537AUS1YOR011WverifiedTransporter of the ATP-binding cassette family, involved inuptake of sterols and anaerobic growth 0.004990.13433&radic&radic S000001936SAP155YFR040WverifiedProtein that forms a complex with the Sit4p protein phosphataseand is required for its function; member of afamily of similar proteins including Sap4p,Sap185p, and Sap190p 0.004980.13424&radic S000000122LSM2YBL026WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.004970.13409&radic&radic&radic S000002765YDR357CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.004970.13409&radic S000000597YCP4YCR004CverifiedProtein of unknown function, has sequence and structuralsimilarity to flavodoxins; the authentic,non-tagged protein is detected in highlypurified mitochondria in high-throughputstudies 0.004960.13329&radic S000004641CCS1YMR038CverifiedCopper chaperone for superoxide dismutase Sod1p, involved inoxidative stress protection; Met-X-Cys-X2-Cysmotif within the N-terminal portion is involvedin insertion of copper into Sod1p underconditions of copper deprivation 0.004970.13329&radic S000002537FIN1YDR130CverifiedSpindle pole body-related intermediate filament protein, formscell cycle-specific filaments between spindlepole bodies in mother and daughter cells, ableto self-assemble, expression induced duringS/G2, localization cell-cycle dependent 0.004940.13329&radic S000005782TRE2YOR256CverifiedProtein of unknown function with similarity to TRE1/YPL176C;required for cell viability 0.004960.13329&radic&radic S000000404BEM1YBR200WverifiedProtein containing SH3-domains, involved in establishing cellpolarity and morphogenesis; functions as ascaffold protein for complexes that includeCdc24p, Ste5p, Ste20p, and Rsr1p 0.004970.13329&radic&radic S000000016YAL018CUncharacterizedHypothetical protein 0.004920.13197&radic&radic S000001083SRB2YHR041CverifiedGeneral transcription factor, subunit of the RNA polymerase IImediator complex; associates with corepolymerase subunits to form the RNA polymeraseII holoenzyme; involved in telomere maintenance 0.004920.13197 S000005117MDG1YNL173CverifiedPlasma membrane protein involved in G-protein mediatedpheromone signaling pathway; overproductionsuppresses bem1 mutations 0.004910.13197&radic S000002781FRQ1YDR373WverifiedN-myristoylated calcium-binding protein that may have a role inintracellular signaling through its regulationof the phosphatidylinositol 4-kinase Pik1p;member of the recoverin/frequenin branch of theEF-hand superfamily 0.00490.13197&radic&radic S000005213BSC4YNL269WverifiedProtein of unknown function, ORF exhibits genomic organizationcompatible with a translationalreadthrough-dependent mode of expression;readthrough is increased upon depletion ofSup35p 0.004920.13197&radic&radic S000004920UBP15YMR304WverifiedUbiquitin-specific protease that may play a role in ubiquitinprecursor processing 0.00490.13197&radic&radic S000000545GLK1YCL040WverifiedGlucokinase, catalyzes the phosphorylation of glucose at C6 inthe first irreversible step of glucosemetabolism; one of three glucosephosphorylating enzymes; expression regulatedby non-fermentable carbon sources 0.004930.13197 S000000557PBN1YCL052CverifiedEssential component ofglycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalyticpost-translational processing of the protease Bprecursor Prb1p, localizes to ER in lumenalorientation; homolog of mammalian PIG-X 0.00490.13197&radic S000005456COQ3YOL096CverifiedO-methyltransferase, catalyzes two different O-methylationsteps in ubiquinone (Coenzyme Q) biosynthesis;component of a mitochondrialubiquinone-synthesizing complex 0.004910.13197&radic S000004391BDF1YLR399CverifiedProtein involved in transcription initiation at TATA-containingpromoters; associates with the basaltranscription factor TFIID; contains twobromodomains; corresponds to the C-terminalregion of mammalian TAF1; redundant with Bdf2p 0.004930.13197&radic&radic S000006087ATG29YPL166WuncharacterizedProtein specifically required for autophagy; may function inautophagosome formation at thepre-autophagosomal structure in collaborationwith other autophagy proteins 0.004920.13197 S000001160ORC6YHR118CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing; may be phosphorylated by Cdc28p 0.004890.13141&radic S000002491TVP23YDR084CuncharacterizedIntegral membrane protein localized to late Golgi vesiclesalong with the v-SNARE Tlg2p; green fluorescentprotein (GFP)-fusion protein localizes to thecytoplasm in a punctate pattern 0.00490.13141 S000004095SEN2YLR105CverifiedSubunit of the tRNA splicing endonuclease, which is composed ofSen2p, Sen15p, Sen34p, and Sen54p; Sen2pcontains the active site for tRNA 5' splicesite cleavage and has similarity to Sen34p andto Archaeal tRNA splicing endonuclease 0.004890.13141&radic S000000180CDC27YBL084CverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 0.004890.13141&radic S000002887PEX29YDR479CverifiedPeroxisomal integral membrane protein, involved in regulationof peroxisome size and number; geneticinteractions suggest that Pex28p and Pex29p actat steps upstream of those mediated by Pex30p,Pex31p, and Pex32p 0.004870.13122 S000005122RPS3YNL178WverifiedProtein component of the small (40S) ribosomal subunit, hasapurinic/apyrimidinic (AP) endonucleaseactivity; essential for viability; hassimilarity to E. coli S3 and rat S3 ribosomalproteins 0.004880.13122&radic&radic S000002773ESF1YDR365CverifiedNucleolar protein involved in pre-rRNA processing; depletioncauses severely decreased 18S rRNA levels 0.004880.13122&radic S000003407ERG1YGR175CverifiedSqualene epoxidase, catalyzes the epoxidation of squalene to2,3-oxidosqualene; plays an essential role inthe ergosterol-biosynthesis pathway and is thespecific target of the antifungal drugterbinafine 0.004870.13122 S000002384SHS1YDL225WverifiedOne of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p,Shs1p) that form a cortical filamentous collarat the mother-bud neck which is necessary fornormal morphogenesis and cytokinesis 0.004870.13108&radic S000004169YLR179CUncharacterizedProtein of unknown function, transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus; YLR179C is not essential 0.004870.13108 S000000015PSK1YAL017WverifiedOne of two (see also PSK2) PAS domain containing S/T proteinkinases; coordinately regulates proteinsynthesis and carbohydrate metabolism andstorage in response to a unknown metabolitethat reflects nutritional status 0.004830.12939&radic S000003329ASK10YGR097WverifiedComponent of the RNA polymerase II holoenzyme, phosphorylatedin response to oxidative stress; has a role indestruction of Ssn8p, which relieves repressionof stress-response genes 0.004840.12939&radic S000006189PLC1YPL268WverifiedPhosphoinositide-specific phospholipase C, hydrolyzesphosphatidylinositol 4,5-biphosphate (PIP2) togenerate inositol 1,4,5-triphosphate (IP3) and1,2-diacylglycerol (DAG); involved inkinetochore function and pseudohyphaldifferentiation 0.004860.12939 S000002351ARF1YDL192WverifiedADP-ribosylation factor, GTPase of the Ras superfamily involvedin regulation of coated formation vesicles inintracellular trafficking within the Golgi;functionally interchangeable with Arf2p 0.004820.12939&radic S000002951YDR543CDubiousHypothetical protein 0.004850.12939&radic S000004057PET309YLR067CverifiedSpecific translational activator for the COX1 mRNA, alsoinfluences stability of intron-containing COX1primary transcripts; located in themitochondrial inner membrane 0.004810.12934&radic S000003430YPP1YGR198WverifiedCargo-transport protein involved in endocytosis; may interactwith ribosomes, based on co-purificationexperiments; GFP-fusion protein localizes tothe cytoplasm; YGR198W is an essential gene 0.004810.12934 S000005573STD1YOR047CverifiedProtein involved in control of glucose-regulated geneexpression; interacts with protein kinaseSnf1p, glucose sensors Snf3p and Rgt2p, andTATA-binding protein Spt15p; acts as aregulator of the transcription factor Rgt1p &radic0.004810.12911&radic&radic&radic S000001873GAT1YFL021WverifiedTranscriptional activator of genes involved in nitrogencatabolite repression, member of the GATAfamily of DNA binding proteins; activity andlocalization regulated by nitrogen limitationand Ure2p 0.004780.12855&radic&radic S000005008YDJ1YNL064CverifiedProtein chaperone involved in regulation of the HSP90 and HSP70functions; involved in protein translocationacross membranes; member of the DnaJ family 0.004790.12855 S000002701SSD1YDR293CverifiedProtein with a role in maintenance of cellular integrity,interacts with components of the TOR pathway;ssd1 mutant of a clinical S. cerevisiae straindisplays elevated virulence 0.00480.12855&radic S000001084NCP1YHR042WverifiedNADP-cytochrome P450 reductase; involved in ergosterolbiosynthesis; associated and coordinatelyregulated with Erg11p 0.004780.12744&radic&radic S000002892VPS52YDR484WverifiedComponent of the GARP (Golgi-associated retrograde protein)complex, Vps51p-Vps52p-Vps53p-Vps54p, which isrequired for the recycling of proteins fromendosomes to the late Golgi; involved inlocalization of actin and chitin 0.004780.12744&radic S000000482DPB3YBR278WverifiedThird-largest subunit of DNA polymerase II (DNA polymeraseepsilon), required to maintain fidelity ofchromosomal replication and also forinheritance of telomeric silencing; mRNAabundance peaks at the G1/S boundary of thecell cycle 0.004750.12744&radic S000005318ARC35YNR035CverifiedSubunit of the ARP2/3 complex, which is required for themotility and integrity of cortical actinpatches; required for cortical localization ofcalmodulin 0.004770.12744 S000003973COF1YLL050CverifiedCofilin, promotes actin filament depolarization in apH-dependent manner; binds both actin monomersand filaments and severs filaments , thought tobe regulated by phosphorylation at SER4,ubiquitous and essential in eukaryotes 0.004770.12744&radic S000003993YLR003CUncharacterizedPutative protein of unknown function that may participate in DNA replication; green fluorescent protein (GFP)-fusion protein is localized to the nucleus; YLR003C is not an essential gene 0.004780.12744&radic&radic&radic S000003642IME2YJL106WverifiedSerine/threonine protein kinase involved in activation ofmeiosis, associates with Ime1p and mediates itsstability, activates Ndt80p; IME2 expression ispositively regulated by Ime1p 0.004780.12744 S000002385GCS1YDL226CverifiedADP-ribosylation factor GTPase activating protein (ARF GAP),involved in ER-Golgi transport; sharesfunctional similarity with Glo3p 0.004720.12665&radic S000004353DCR2YLR361CverifiedPutative phosphoesterase that functions as a dosage-dependentpositive regulator of the G1/S phase transitionby controlling the timing of START 0.004730.12665 S000004928GLC8YMR311CverifiedRegulatory subunit of protein phosphatase 1 (Glc7p), involvedin glycogen metabolism and chromosomesegregation; proposed to regulate Glc7pactivity via conformational alteration;ortholog of the mammalian protein phosphataseinhibitor 2 0.004740.12665 S000001346SDS3YIL084CverifiedComponent of the Rpd3p/Sin3p deacetylase complex required forits structural integrity and catalyticactivity, involved in transcriptional silencingand required for sporulation; cells defectivein SDS3 display pleiotropic phenotypes 0.004740.12665&radic S000004312MMS22YLR320WverifiedProtein involved in resistance to ionizing radiation; acts withMms1p in a repair pathway that may be involvedin resolving replication intermediates orpreventing the damage caused by blockedreplication forks 0.004730.12665&radic&radic S000006135THI6YPL214CverifiedBifunctional enzyme with thiamine-phosphate pyrophosphorylaseand 4-methyl-5-beta-hydroxyethylthiazole kinaseactivities, required for thiamine biosynthesis;GFP-fusion protein localizes to the cytoplasmin a punctate pattern 0.004730.12665 S000003267YGR035CUncharacterizedPutative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance 0.004730.12665&radic S000002283HNT1YDL125CverifiedAdenosine 5'-monophosphoramidase; interacts physically andgenetically with Kin28p, a CDK and TFIIKsubunit, and genetically with CAK1; member ofthe histidine triad (HIT) superfamily ofnucleotide-binding proteins and similar to Hint 0.004740.12665 S000000266YBR062CUncharacterizedHypothetical protein 0.004710.12576 S000001668ASH1YKL185WverifiedZinc-finger inhibitor of HO transcription; mRNA is localizedand translated in the distal tip of anaphasecells, resulting in accumulation of Ash1p indaughter cell nuclei and inhibition of HOexpression; potential Cdc28p substrate 0.00470.12576&radic S000005404PEX15YOL044WverifiedPhosphorylated tail-anchored type II integral peroxisomalmembrane protein required for peroxisomebiogenesis, cells lacking Pex15p mislocalizeperoxisomal matrix proteins to cytosol,overexpression results in impaired peroxisomeassembly 0.004710.12576 S000000835ZRG8YER033CverifiedProtein of unknown function; authentic, non-tagged protein isdetected in highly purified mitochondria inhigh-throughput studies; GFP-fusion protein islocalized to the cytoplasm; transcriptioninduced under conditions of zinc deficiency 0.004690.12576&radic&radic S000001769KTR2YKR061WverifiedMannosyltransferase involved in N-linked protein glycosylation;member of the KRE2/MNT1 mannosyltransferasefamily 0.00470.12576&radic&radic S000003842EAF6YJR082CuncharacterizedEsa1p-associated factor, subunit of the NuA4 acetyltransferasecomplex 0.00470.12576 S000005735NPT1YOR209CverifiedNicotinate phosphoribosyltransferase, acts in the salvagepathway of NAD+ biosynthesis; required forsilencing at rDNA and telomeres and has a rolein silencing at mating-type loci; localized tothe nucleus 0.004690.12576&radic S000001445PAN1YIR006CverifiedPart of actin cytoskeleton-regulatory complexPan1p-Sla1p-End3p, associates with actinpatches on the cell cortex; promotesprotein-protein interactions essential forendocytosis; previously thought to be a subunitof poly(A) ribonuclease 0.004710.12576 S000003667YJL131CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria; YJL131C is a non-essential gene 0.00470.12576&radic&radic&radic S000000991YER189WUncharacterizedHypothetical protein 0.004690.12515&radic S000000256RFS1YBR052CuncharacterizedProtein of unknown function; member of a flavodoxin-like foldprotein family that includes Pst2p and Ycp4p;green fluorescent protein (GFP)-fusion proteinlocalizes to the cytoplasm in a punctatepattern 0.004680.12515 S000004536COG8YML071CverifiedComponent of the conserved oligomeric Golgi complex (Cog1pthrough Cog8p), a cytosolic tethering complexthat functions in protein trafficking tomediate fusion of transport vesicles to Golgicompartments 0.004680.12515 S000005606DIA2YOR080WverifiedOrigin-binding F-box protein that forms an SCF ubiquitin ligasecomplex with Skp1p and Cdc53p; plays a role inDNA replication, involved in invasive andpseudohyphal growth 0.004690.12515&radic S000001728VPS51YKR020WverifiedComponent of the GARP (Golgi-associated retrograde protein)complex, Vps51p-Vps52p-Vps53p-Vps54p, which isrequired for the recycling of proteins fromendosomes to the late Golgi; links the(VFT/GARP) complex to the SNARE Tlg1p 0.004670.12474&radic S000005564HIR2YOR038CverifiedNon-essential transcriptional corepressor involved in the cellcycle-regulated transcription of histone H2A,H2B, H3, and H4 genes; recruits Swi-Snfcomplexes to histone gene promoters; promotesheterochromatic gene silencing with Asf1p 0.004660.12474&radic&radic S000004773INP2YMR163CverifiedPeroxisome-specific receptor important for peroxisomeinheritance; co-fractionates with peroxisomemembranes and co-localizes with peroxisomes invivo; physically interacts with the myosin Vmotor Myo2p; INP2 is not an essential gene 0.004670.12474&radic S000000729GIM4YEL003WverifiedSubunit of the heterohexameric cochaperone prefoldin complexwhich binds specifically to cytosolicchaperonin and transfers target proteins to it 0.004670.12474&radic&radic S000004743YMR135W-ADubiousHypothetical protein 0.004660.12474&radic S000001165EPT1YHR123Wverifiedsn-1,2-diacylglycerol ethanolamine- andcholinephosphotranferase; not essential forviability 0.004630.12381&radic S000002461CDC34YDR054CverifiedUbiquitin-conjugating enzyme or E2; together with Skp1p, Rbx1p,Cdc53p, and an F-box protein, forms aubiquitin-protein ligase called the SCF complexwhich regulates cell cycle progression bytargeting key substrates for degradation 0.004640.12381&radic&radic&radic S000004284GSP1YLR293CverifiedGTP binding protein (mammalian Ranp homolog) involved in themaintenance of nuclear organization, RNAprocessing and transport; regulated by Prp20p,Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p andKap95p; yeast Gsp2p homolog 0.004630.12381&radic S000003566VPS53YJL029CverifiedComponent of the GARP (Golgi-associated retrograde protein)complex, Vps51p-Vps52p-Vps53p-Vps54p, which isrequired for the recycling of proteins fromendosomes to the late Golgi; required forvacuolar protein sorting 0.004630.12381 S000006084SVS1YPL163CverifiedCell wall and vacuolar protein, required for wild-typeresistance to vanadate 0.004640.12381&radic S000003187MDM34YGL219CverifiedMitochondrial outer membrane protein, required for normalmitochondrial morphology and inheritance;localizes to dots on the mitochondrial surfacenear mtDNA nucleoids; interacts geneticallywith MDM31 and MDM32 0.004630.12381 S000004860FAA4YMR246WverifiedLong chain fatty acyl-CoA synthetase, regulates proteinmodification during growth in the presence ofethanol, functions to incorporate palmitic acidinto phospholipids and neutral lipids 0.004650.12381&radic&radic S000001831YFL063WDubiousDubious open reading frame, based on available experimental and comparative sequence data 0.004650.12381&radic S000002964YFL012W-ADubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene IES1/YFL013C 0.004640.12381&radic S000003528YRF1-3YGR296WverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p 0.004640.12381&radic S000002657YDR249CUncharacterizedHypothetical protein 0.004640.12381&radic S000004425CNA1YLR433CverifiedCalcineurin A; one isoform (the other is CMP2) of the catalyticsubunit of calcineurin, aCa++/calmodulin-regulated protein phosphatasewhich regulates Crz1p (a stress-responsetranscription factor), the other calcineurinsubunit is CNB1 0.004640.12381 S000002190YDL032WDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene 0.004650.12381&radic S000000935GLC7YER133WverifiedCatalytic subunit of type 1 serine/threonine proteinphosphatase, involved in many processesincluding glycogen metabolism, sporulation, andmitosis; interacts with multiple regulatorysubunits; predominantly isolated with Sds22p 0.004630.12381 S000000204YBL108WDubiousHypothetical protein 0.004650.12381&radic S000000264ORC2YBR060CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing; may be phosphorylated by Cdc28p 0.004630.12381 S000002659PAM1YDR251WverifiedEssential protein of unknown function; exhibits variableexpression during colony morphogenesis;overexpression permits survival without proteinphosphatase 2A, inhibits growth, and induces afilamentous phenotype 0.004610.1232&radic S000001580YKL097CDubiousDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species 0.004610.1232&radic&radic S000000209RCR1YBR005WverifiedProtein of the endoplasmic reticulum membrane involved inchitin deposition in the cell wall;overproduction confers resistance to Congo Red 0.004620.1232&radic S000001053DIA4YHR011WverifiedProbable mitochondrial seryl-tRNA synthetase, mutant displaysincreased invasive and pseudohyphal growth 0.004620.1232&radic&radic S000002956YEL075W-ADubiousHypothetical protein 0.004620.1232&radic&radic S000004184YLR194CUncharacterizedStructural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress 0.004620.1232&radic S000003193VRG4YGL225WverifiedGolgi GDP-mannose transporter; regulates Golgi function andglycosylation in Golgi 0.00460.12299&radic&radic&radic S000005552BUB3YOR026WverifiedKinetochore checkpoint WD40 repeat protein that localizes tokinetochores during prophase and metaphase,delays anaphase in the presence of unattachedkinetochores; forms complexes with Mad1p-Bub1pand with Cdc20p, binds Mad2p and Mad3p 0.00460.12299&radic S000001829YFL065CUncharacterizedPutative protein of unknown function 0.00460.12251&radic S000001524VPS24YKL041WverifiedOne of four subunits of the endosomal sorting complex requiredfor transport III (ESCRT-III); forms anESCRT-III subcomplex with Did4p; involved inthe sorting of transmembrane proteins into themultivesicular body (MVB) pathway 0.00460.12251&radic&radic S000000157SKT5YBL061CverifiedActivator of Chs3p (chitin synthase III), recruits Chs3p to thebud neck via interaction with Bni4p; hassimilarity to Shc1p, which activates Chs3pduring sporulation 0.004580.12201&radic&radic S000003651ASF1YJL115WverifiedNucleosome assembly factor, involved in chromatin assembly anddisassembly, anti-silencing protein that causesderepression of silent loci when overexpressed 0.004580.12201&radic S000000966CHD1YER164WverifiedNucleosome remodeling factor that functions in regulation oftranscription elongation; contains a chromodomain, a helicase domain and a DNA-bindingdomain; component of both the SAGA and SILKcomplexes 0.004560.12105 S000003398KRE11YGR166WverifiedProtein involved in biosynthesis of cell wall beta-glucans;subunit of the TRAPP (transport proteinparticle) complex, which is involved in thelate steps of endoplasmic reticulum to Golgitransport 0.004560.12105&radic&radic S000006071YPL150WUncharacterizedHypothetical protein 0.004560.12105&radic&radic S000002208YDL050CDubiousHypothetical protein 0.004540.12105&radic S000006125HRR25YPL204WverifiedProtein kinase involved in regulating diverse events includingvesicular trafficking, gene expression, DNArepair, and chromosome segregation; binds theCTD of RNA pol II; homolog of mammalian caseinkinase 1delta (CK1delta) 0.004550.12105&radic S000002787RGA2YDR379WverifiedGTPase-activating protein for the polarity-establishmentprotein Cdc42p; implicated in control of septinorganization, pheromone response, and haploidinvasive growth 0.004560.12105&radic S000002333DLD1YDL174CverifiedD-lactate dehydrogenase, oxidizes D-lactate to pyruvate,transcription is heme-dependent, repressed byglucose, and derepressed in ethanol or lactate;located in the mitochondrial inner membrane 0.004540.121&radic S000005691SEY1YOR165WverifiedProtein of unknown function, contains two predicted GTP-bindingmotifs GXXXXGKS and DXXG near the N-terminus,homolog of the Arabidopsis gene RHD3 (Root HairDefective) 0.004530.12063&radic S000001504MAK11YKL021CverifiedProtein essential for cell growth and replication of M dsRNAvirus; contains four beta-transducin repeats 0.004530.12063&radic&radic S000000760HYP2YEL034WverifiedTranslation initiation factor eIF-5A, promotes formation of thefirst peptide bond; similar to and functionallyredundant with Anb1p; possible role intranslation elongation; undergoes an essentialhypusination modification 0.004530.12063 S000004208YLR218CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR218C is not essential; mutants exhibit glycogen storage defects and growth defects on a non-fermentable carbon source 0.004530.12053&radic S000000036CDC19YAL038WverifiedPyruvate kinase, functions as a homotetramer in glycolysis toconvert phosphoenolpyruvate to pyruvate, theinput for aerobic (TCA cycle) or anaerobic(glucose fermentation) respiration 0.004520.12004&radic&radic S000003681SFH5YJL145WverifiedPutative phosphatidylinositol transfer protein (PITP), exhibitsphosphatidylinositol- but notphosphatidylcholine-transfer activity, mainlylocalized to cytosol and microsomes, similar toSec14p; may be PITP regulator rather thanactual PITP 0.004520.12004&radic&radic&radic S000004579BUL2YML111WverifiedComponent of the Rsp5p E3-ubiquitin ligase complex, involved inintracellular amino acid permease sorting,functions in heat shock element mediated geneexpression, essential for growth in stressconditions, functional homolog of BUL1 0.004530.12004&radic S000002472YDR065WUncharacterizedProtein of unknown function, required for vacuolar acidification 0.004520.12004&radic&radic&radic S000006383HDA3YPR179CverifiedSubunit of a possibly tetrameric trichostatin A-sensitive classII histone deacetylase complex that contains anHda1p homodimer and an Hda2p-Hda3p heterodimer;required for the activity of the complex; hassimilarity to Hda2p 0.00450.11865&radic&radic S000002216USO1YDL058WverifiedEssential protein involved in intracellular protein transport,coiled-coil protein necessary for transportfrom ER to Golgi; required for assembly of theER-to-Golgi SNARE complex 0.004480.11865 S000002519IRC2YDR112WdubiousHypothetical protein, null mutant displays increased levels ofspontaneous Rad52 foci 0.00450.11865&radic&radic S000004789MMT1YMR177WverifiedPutative metal transporter involved in mitochondrial ironaccumulation; closely related to Mmt2p 0.004510.11865&radic S000000739VAC8YEL013WverifiedPhosphorylated vacuolar membrane protein that interacts withAtg13p, required for the cytoplasm-to-vacuoletargeting (Cvt) pathway; interacts with Nvj1pto form nucleus-vacuole junctions 0.004470.11865&radic&radic S000000682CSM1YCR086WverifiedNucleolar protein that forms a complex with Lrs4p which bindsMam1p at kinetochores during meiosis I tomediate accurate chromosome segregation, may beinvolved in premeiotic DNA replication;possible role in telomere maintenance 0.00450.11865 S000000856GIP2YER054CverifiedPutative regulatory subunit of the protein phosphatase Glc7p,involved in glycogen metabolism; contains aconserved motif (GVNK motif) that is also foundin Gac1p, Pig1p, and Pig2p 0.004480.11865&radic S000003018TYW3YGL050WuncharacterizedHypothetical protein 0.004490.11865&radic S000001102VMA22YHR060WverifiedIntegral membrane protein that is required for vacuolarH+-ATPase (V-ATPase) function, although not anactual component of the V-ATPase complex;functions in the assembly of the V-ATPase;localized to the yeast endoplasmic reticulum(ER) 0.004480.11865&radic&radic S000003929MMM1YLL006WverifiedMitochondrial outer membrane protein required for normalmitochondrial morphology and mtDNA stability;involved in tethering mitochondria to the actincytoskeleton and in anchoring mtDNA nucleoids 0.004480.11865&radic&radic&radic S000002474OCA6YDR067CuncharacterizedCytoplasmic protein required for replication of Brome mosaicvirus in S. cerevisiae, which is a model systemfor studying replication of positive-strand RNAviruses in their natural hosts 0.004490.11865&radic&radic&radic S000005664RUP1YOR138CverifiedProtein involved in regulation of Rsp5p, which is an essentialHECT ubiquitin ligase; required for binding ofRsp5p to Ubp2p; contains an UBA domain 0.00450.11865&radic&radic&radic S000003175SPT16YGL207WverifiedSubunit of the heterodimeric FACT complex (Spt16p-Pob3p),facilitates RNA Polymerase II transcriptionelongation through nucleosomes by destabilizingand then reassembling nucleosome structure 0.004510.11865&radic S000002304COP1YDL145CverifiedAlpha subunit of COPI vesicle coatomer complex, which surroundstransport vesicles in the early secretorypathway 0.004480.11865 S000000389MBA1YBR185CverifiedProtein involved in assembly of mitochondrial respiratorycomplexes; may act as a receptor for proteinsdestined for export from the mitochondrialmatrix to the inner membrane 0.00450.11865&radic&radic S000000920SHO1YER118CverifiedTransmembrane osmosensor, participates in activation of boththe Cdc42p- and MAP kinase-dependentfilamentous growth pathway and thehigh-osmolarity glycerol response pathway 0.004490.11865 S000003335NOP7YGR103WverifiedNucleolar protein involved in rRNA processing and 60S ribosomalsubunit biogenesis; constituent of severaldifferent pre-ribosomal particles; required forexit from G0 and the initiation ofcell proliferation 0.004470.11846&radic S000006270UBA3YPR066WverifiedProtein that acts together with Ula1p to activate Rub1p beforeits conjugation to proteins (neddylation),which may play a role in protein degradation;GFP-fusion protein localizes to the cytoplasmin a punctate pattern 0.004470.11846 S000007236SNA2YDR525W-AverifiedProtein of unknown function, has similarity to Pmp3p, which isinvolved in cation transport; green fluorescentprotein (GFP)-fusion protein localizes to thecytoplasm in a punctate pattern 0.004470.11846 S000000022LTE1YAL024CverifiedPutative GDP/GTP exchange factor required for mitotic exit atlow temperatures; acts as a guanine nucleotideexchange factor (GEF) for Tem1p, which is a keyregulator of mitotic exit; physicallyassociates with Ras2p-GTP 0.004450.11776 S000004742GID8YMR135CverifiedProtein of unknown function, involved in proteasome-dependentcatabolite inactivation offructose-1,6-bisphosphatase; contains LisH andCTLH domains, like Vid30p; dosage-dependentregulator of START 0.004440.11754 S000003849BIR1YJR089WverifiedEssential chromosomal passenger protein involved incoordinating cell cycle events for properchromosome segregation; C-terminal region bindsSli15p, and the middle region, uponphosphorylation, localizes Cbf2p to the spindleat anaphase 0.004430.11721&radic S000005544ROD1YOR018WverifiedMembrane protein; overexpression confers resistance to the GSTsubstrate o-dinitrobenzene as well as to zincand calcium; contains 2 PY motifs, which arerequired for Rod1p interaction with Rsp5p, ahect-type ubiquitin ligase 0.004430.11721&radic&radic S000001596RAD27YKL113Cverified5' to 3' exonuclease, 5' flap endonuclease, required forOkazaki fragment processing and maturation aswell as for long-patch base-excision repair;member of the S. pombe RAD2/FEN1 family 0.004440.11721&radic&radic&radic S000002462PST1YDR055WverifiedCell wall protein that contains a putative GPI-attachment site;secreted by regenerating protoplasts;up-regulated by activation of the cellintegrity pathway, as mediated by Rlm1p;upregulated by cell wall damage via disruptionof FKS1 0.004420.117&radic S000003196VID30YGL227WverifiedProtein involved in proteasome-dependent catabolite degradationof fructose-1,6-bisphosphatase (FBPase); shiftsthe balance of nitrogen metabolism toward theproduction of glutamate; localized to thenucleus and the cytoplasm 0.004410.11665&radic&radic S000001531ELM1YKL048CverifiedSerine/threonine protein kinase that regulates cellularmorphogenesis, septin behavior, andcytokinesis; required for the regulation ofother kinases; forms part of the bud neck ring 0.004420.11665&radic&radic S000003469YGR237CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.004420.11665&radic S000005187SLA2YNL243WverifiedTransmembrane actin-binding protein involved in membranecytoskeleton assembly and cell polarization;adaptor protein that links actin to clathrinand endocytosis; present in the actin corticalpatch of the emerging bud tip; dimer in vivo 0.004410.11665 S000000689CDC39YCR093WverifiedComponent of the CCR4-NOT complex, which has multiple roles inregulating mRNA levels including regulation oftranscription and destabilizing mRNAs bydeadenylation; basal transcription factor 0.004420.11665&radic S000005558HMS1YOR032CverifiedBasic helix-loop-helix (bHLH) protein with similarity tomyc-family transcription factors;overexpression confers hyperfilamentous growthand suppresses the pseudohyphal filamentationdefect of a diploid mep1 mep2 homozygous nullmutant 0.004410.11664&radic S000001676SDS22YKL193CverifiedConserved nuclear regulatory subunit of Glc7p type 1 proteinserine-threonine phosphatase (PP1), functionspositively with Glc7p to promotedephosphorylation of nuclear substratesrequired for chromosome transmission duringmitosis 0.004410.11652&radic S000005680SLP1YOR154WuncharacterizedHypothetical protein 0.004410.11652&radic S000001458MUC1YIR019CverifiedGPI-anchored cell surface glycoprotein required for diploidpseudohyphal formation and haploid invasivegrowth, transcriptionally regulated by the MAPKpathway (via Ste12p and Tec1p) and the cAMPpathway (via Flo8p) 0.004410.11652&radic S000001307PIG2YIL045WverifiedPutative type-1 protein phosphatase targeting subunit thattethers Glc7p type-1 protein phosphatase toGsy2p glycogen synthase 0.00440.11643&radic S000004002YLR012CUncharacterizedPutative protein of unknown function; YLR012C is not an essential gene 0.00440.11643&radic S000000471REI1YBR267WverifiedCytoplasmic pre-60S factor; required for the correct recyclingof shuttling factors Alb1, Arx1 and Tif6 at theend of the ribosomal large subunit biogenesis;involved in bud growth in the mitotic signalingnetwork 0.004390.116&radic S000004039YLR049CUncharacterizedHypothetical protein 0.00440.116&radic&radic&radic S000002292PPH21YDL134CverifiedCatalytic subunit of protein phosphatase 2A, functionallyredundant with Pph22p; methylated at Cterminus; forms alternate complexes withseveral regulatory subunits; involved in signaltransduction and regulation of mitosis 0.004390.116 S000002178RPN4YDL020CverifiedTranscription factor that stimulates expression of proteasomegenes; Rpn4p levels are in turn regulated bythe 26S proteasome in a negative feedbackcontrol mechanism; RPN4 is transcriptionallyregulated by various stress responses 0.00440.116 S000003674TIF2YJL138CverifiedTranslation initiation factor eIF4A, identical to Tif1p;DEA(D/H)-box RNA helicase that couples ATPaseactivity to RNA binding and unwinding; forms adumbbell structure of two compact domainsconnected by a linker; interacts with eIF4G 0.00440.116&radic&radic S000002273IWR1YDL115CuncharacterizedProtein of unknown function, deletion causes hypersensitivityto the K1 killer toxin 0.004380.11546 S000005895RAD17YOR368WverifiedCheckpoint protein, involved in the activation of the DNAdamage and meiotic pachytene checkpoints; withMec3p and Ddc1p, forms a clamp that is loadedonto partial duplex DNA; homolog of human andS. pombe Rad1 and U. maydis Rec1 proteins 0.004370.11524&radic S000001051YHR009CUncharacterizedPutative protein of unknown function; not an essential gene 0.004370.11524 S000004062YLR072WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene 0.004340.11417 S000006359NCA2YPR155CverifiedProtein involved in regulation of mitochondrial expression ofsubunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1ATP synthase; functions with Nca3p 0.004340.11417&radic S000001393FKH1YIL131CverifiedForkhead family transcription factor with a minor role in theexpression of G2/M phase genes; negativelyregulates transcriptional elongation; positiverole in chromatin silencing at HML and HMR;regulates donor preference during switching 0.004360.11417 S000000992YRF1-2YER190WverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p 0.004350.11417&radic S000005563CYC2YOR037WverifiedMitochondrial peripheral inner membrane protein, contains a FADcofactor in a domain exposed in theintermembrane space; exhibits redox activity invitro; likely participates in ligation of hemeto acytochromes c and c1 (Cyc1p and Cyt1p) 0.004350.11417&radic&radic S000005505CTR9YOL145CverifiedComponent of the Paf1p complex, which is a large complex thatbinds to and modulates the activity of RNApolymerase II and is required for expression ofa subset of genes, including cyclin genes;contains TPR repeats 0.004340.11417 S000001163LSM12YHR121WverifiedProtein of unknown function that interacts with Pbp1p and Pbp4pand associates with ribosomes; contains anRNA-binding LSM domain and an AD domain; mayplay a role in RNA processing 0.004330.11391&radic S000002789YRA1YDR381WverifiedNuclear protein that binds to RNA and to Mex67p, required forexport of poly(A)+ mRNA from the nucleus;member of the REF (RNA and export factorbinding proteins) family; another familymember, Yra2p, can substitute for Yra1pfunction 0.004330.11391&radic&radic S000002324CDC36YDL165WverifiedComponent of the CCR4-NOT complex, which has multiple roles inregulating mRNA levels including regulation oftranscription and destabilizing mRNAs bydeadenylation; basal transcription factor 0.004330.11391 S000003486ENO1YGR254WverifiedEnolase I, a phosphopyruvate hydratase that catalyzes theconversion of 2-phosphoglycerate tophosphoenolpyruvate during glycolysis and thereverse reaction during gluconeogenesis;expression is repressed in response to glucose 0.004320.11313&radic S000002851SSN2YDR443CverifiedProtein required for stable association of Srb10p-Srb11p kinasewith RNA polymerase holoenzyme; subunit of theRNA polymerase II mediator complex; essentialfor transcriptional regulation 0.00430.11313 S000003295SPT4YGR063CverifiedProtein that forms a complex with Spt5p and mediates bothactivation and inhibition of transcriptionelongation, and plays a role in pre-mRNAprocessing; in addition, Spt4p is involved inkinetochore function and gene silencing 0.004310.11313 S000001647PIR1YKL164CverifiedO-glycosylated protein required for cell wall stability;attached to the cell wall via beta-1,3-glucan;mediates mitochondrial translocation of Apn1p;expression regulated by the cell integritypathway and by Swi5p during the cell cycle 0.004320.11313&radic&radic S000004322CHS5YLR330WverifiedProtein involved in export from the Golgi to plasma membrane;involved in chitin biosynthesis through itsrole in Chs3p localization; interacts withArf1p, Bch1p, Fmp50p, Bud7p, and Chs6p 0.004310.11313&radic S000003962UBI4YLL039CverifiedUbiquitin, becomes conjugated to proteins, marking them forselective degradation via the ubiquitin-26Sproteasome system; essential for the cellularstress response 0.00430.113&radic S000005827RAX1YOR301WverifiedProtein involved in bud site selection during bipolar budding;localization requires Rax2p; has similarity tomembers of the insulin-related peptidesuperfamily 0.004290.11219&radic S000001672HYM1YKL189WverifiedComponent of the RAM signaling network that is involved inregulation of Ace2p activity and cellularmorphogenesis, interacts with Kic1p and Sog2p,localizes to sites of polarized growth duringbudding and during the mating response 0.004290.11219&radic S000004534POB3YML069WverifiedSubunit of the heterodimeric FACT complex (Spt16p-Pob3p), whichfacilitates RNA Polymerase II transcriptionelongation through nucleosomes by destabilizingand then reassembling nucleosome structure 0.004280.11219 S000003450CRM1YGR218WverifiedMajor karyopherin, involved in export of proteins, RNAs, andribosomal subunits from the nucleus 0.004290.11219&radic&radic&radic S000002786LSM6YDR378CverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.004280.11219&radic S000003310PAC10YGR078CverifiedPart of the heteromeric co-chaperone GimC/prefoldin complex,which promotes efficient protein folding 0.004290.11219 S000002546RUB1YDR139CverifiedUbiquitin-like protein with similarity to mammalian NEDD8;conjugation (neddylation) substrates includethe cullins Cdc53p, Rtt101p, and Cul3p;activated by Ula1p and Uba3p (E1 enzyme pair);conjugation mediated by Ubc12p (E2 enzyme) 0.004280.11219&radic&radic S000001089AAP1YHR047CverifiedArginine/alanine aminopeptidase, overproduction stimulatesglycogen accumulation 0.004290.11219&radic&radic&radic S000004646MCM1YMR043WverifiedTranscription factor involved in cell-type-specifictranscription and pheromone response; plays acentral role in the formation of both repressorand activator complexes 0.004280.11219&radic S000005527RRP6YOR001WverifiedExonuclease component of the nuclear exosome; contributes tothe quality-control system that retains anddegrades aberrant mRNAs in the nucleus 0.004280.11219&radic S000000669SSK22YCR073CverifiedMAP kinase kinase kinase of the HOG1 mitogen-activatedsignaling pathway; functionally redundant with,and homologous to, Ssk2p; interacts with and isactivated by Ssk1p; phosphorylates Pbs2p 0.004270.11219 S000000566MRC1YCL061CverifiedS-phase checkpoint protein found at replication forks, requiredfor DNA replication; also required for Rad53pactivation during DNA replication stress, whereit forms a replication-pausing complex withTof1p and is phosphorylated by Mec1p; proteininvolved in replication checkpoint 0.004270.11219&radic S000005641TRS33YOR115CverifiedOne of 10 subunits of the transport protein particle (TRAPP)complex of the cis-Golgi which mediates vesicledocking and fusion; involved in endoplasmicreticulum (ER) to Golgi membrane traffic 0.004290.11219&radic&radic S000005153SSB2YNL209WverifiedCytoplasmic ATPase that is a ribosome-associated molecularchaperone, functions with J-protein partnerZuo1p; may be involved in the folding ofnewly-synthesized polypeptide chains; member ofthe HSP70 family; homolog of SSB1 0.004260.11127 S000003141KEM1YGL173CverifiedEvolutionarily-conserved 5'-3' exonuclease component ofcytoplasmic processing (P) bodies involved inmRNA decay; plays a role inmicrotubule-mediated processes, filamentousgrowth, ribosomal RNA maturation, and telomeremaintenance 0.004260.11127 S000004193MSS51YLR203CverifiedNuclear encoded protein required for translation of COX1 mRNA;binds to Cox1 protein 0.004260.11127&radic S000006319YPR115WUncharacterizedHypothetical protein 0.004260.11127&radic S000001177YCK1YHR135CverifiedPalmitoylated, plasma membrane-bound casein kinase I isoform;shares redundant functions with Yck2p inmorphogenesis, proper septin assembly,endocytic trafficking; provides an essentialfunction overlapping with that of Yck2p 0.004270.11127 S000000039CDC24YAL041WverifiedGuanine nucleotide exchange factor (GEF or GDP-release factor)for Cdc42p; required for polarity establishmentand maintenance, and mutants have morphologicaldefects in bud formation and shmooing 0.004270.11127 S000000969BCK2YER167WverifiedProtein rich in serine and threonine residues involved inprotein kinase C signaling pathway, whichcontrols cell integrity; overproductionsuppresses pkc1 mutations 0.004270.11127 S000002596CCT6YDR188WverifiedSubunit of the cytosolic chaperonin Cct ring complex, relatedto Tcp1p, essential protein that is requiredfor the assembly of actin and tubulins in vivo;contains an ATP-binding motif 0.004260.11127&radic S000000009SWC3YAL011WverifiedProtein of unknown function, component of the SWR1 complex,which exchanges histone variant H2AZ (Htz1p)for chromatin-bound histone H2A; required forformation of nuclear-associated array of smoothendoplasmic reticulum known as karmellae 0.004250.11127&radic&radic S000002548DOP1YDR141CverifiedProtein of unknown function, essential for viability, involvedin establishing cellular polarity andmorphogenesis; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 0.004260.11127&radic&radic S000004692YMR086WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; YMR086W is not an essential gene; cAMP represses expression 0.004270.11127 S000000458TRS20YBR254CverifiedOne of 10 subunits of the transport protein particle (TRAPP)complex of the cis-Golgi which mediates vesicledocking and fusion; mutations in the humanhomolog cause the spondyloepiphyseal dysplasiatarda (SEDL) disorder 0.004250.11105&radic&radic S000006116APL5YPL195WverifiedDelta adaptin-like subunit of the clathrin associated proteincomplex (AP-3); functions in transport ofalkaline phosphatase to the vacuole via thealternate pathway, suppressor of loss of caseinkinase 1 function 0.004250.11105&radic&radic S000003616SCP160YJL080CverifiedEssential RNA-binding G protein effector of mating responsepathway, predominantly associated with nuclearenvelope and ER, interacts in mRNA-dependentmanner with translating ribosomes via multipleKH domains, similar to vertebrate vigilins 0.004250.11105&radic&radic S000005460PKH2YOL100WverifiedSerine/threonine protein kinase involved insphingolipid-mediated signaling pathway thatcontrols endocytosis; activates Ypk1p andYkr2p, components of signaling cascade requiredfor maintenance of cell wall integrity;redundant with Pkh1p 0.004240.11105 S000000787CIN8YEL061CverifiedKinesin motor protein involved in mitotic spindle assembly andchromosome segregation 0.004220.11016 S000003620ALY2YJL084CverifiedCytoplasmic protein of unknown function that interacts with thecyclin Pcl7p; phosphorylated in vitro by thecyclin-CDK complex, Pcl7p-Pho85p; identified asa potential Cdc28p substrate; mRNA is cellcycle regulated, peaking in M phase 0.004220.11016 S000004421CRN1YLR429WverifiedCoronin, cortical actin cytoskeletal component that associateswith the Arp2p/Arp3p complex to regulate itsactivity 0.004220.11016 S000004099AHP1YLR109WverifiedThiol-specific peroxiredoxin, reduces hydroperoxides to protectagainst oxidative damage; function in vivorequires covalent conjugation to Urm1p 0.004190.10936 S000005372HTZ1YOL012CverifiedHistone variant H2AZ, exchanged for histone H2A in nucleosomesby the SWR1 complex; involved intranscriptional regulation through preventionof the spread of silent heterochromatin 0.004190.10936 S000001643ELF1YKL160WverifiedTranscription elongation factor that contains a conserved zincfinger domain; implicated in the maintenance ofproper chromatin structure in activelytranscribed regions; deletion inhibits Bromemosaic virus (BMV) gene expression 0.004190.10936&radic S000002213PSA1YDL055CverifiedGDP-mannose pyrophosphorylase (mannose-1-phosphateguanyltransferase), synthesizes GDP-mannosefrom GTP and mannose-1-phosphate in cell wallbiosynthesis; required for normal cell wallstructure 0.00420.10936 S000002142PAU8YAL068CuncharacterizedHypothetical protein 0.00420.10936&radic&radic S000005195NRD1YNL251CverifiedRNA-binding protein that interacts with the C-terminal domainof the RNA polymerase II large subunit(Rpo21p), required for transcriptiontermination and 3' end maturation ofnonpolyadenylated RNAs 0.004180.10908 S000001341AIR1YIL079CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p to regulate methylationof Npl3p, which modulates Npl3p function inmRNA processing and export; has similarity toAir2p 0.004180.10908&radic&radic&radic S000005730DED1YOR204WverifiedATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, requiredfor translation initiation of all yeast mRNAs;mutations in human DEAD-box DBY are a frequentcause of male infertility 0.004180.10902&radic S000004497SRC1YML034WverifiedProtein with a putative role in sister chromatid segregation,potentially phosphorylated by Cdc28p; greenfluorescent protein (GFP)-fusion proteinlocalizes to the nuclear periphery 0.004170.1088&radic&radic S000000905SSA4YER103WverifiedHeat shock protein that is highly induced upon stress; plays arole in SRP-dependent cotranslationalprotein-membrane targeting and translocation;member of the HSP70 family; cytoplasmic proteinthat concentrates in nuclei upon starvation 0.004170.1088 S000004972CRZ1YNL027WverifiedTranscription factor that activates transcription of genesinvolved in stress response; nuclearlocalization is positively regulated bycalcineurin-mediated dephosphorylation 0.004160.1085 S000001352ICE2YIL090WverifiedIntegral ER membrane protein with type-III transmembranedomains; mutations cause defects in cortical ERmorphology in both the mother and daughtercells 0.004170.1085&radic&radic S000005790DSE3YOR264WverifiedDaughter cell-specific protein, may help establish daughterfate 0.004170.1085&radic&radic S000003167YGL199CDubiousDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W 0.004170.1085 S000005011RPL9BYNL067WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl9Ap and has similarity to E.coli L6 and rat L9 ribosomal proteins 0.004160.10838 S000005105CBK1YNL161WverifiedSerine/threonine protein kinase that regulates cellmorphogenesis pathways; involved in cell wallbiosynthesis, apical growth, proper matingprojection morphology, bipolar bud siteselection in diploid cells, and cell separation 0.004160.10838&radic S000003738YJL202CDubiousHypothetical protein; open reading frame overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex 0.004160.10838&radic&radic S000001745SPC34YKR037CverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; also localized tonuclear side of spindle pole body 0.004150.10814&radic S000000885GET2YER083CverifiedSubunit of the GET complex; required for meiotic nucleardivision and for the retrieval of HDEL proteinsfrom the Golgi to the ER in an ERD2 dependentfashion; may be involved in cell wall function 0.004150.10814&radic S000000737GLC3YEL011WverifiedGlycogen branching enzyme, involved in glycogen accumulation;green fluorescent protein (GFP)-fusion proteinlocalizes to the cytoplasm in a punctatepattern 0.004150.10814&radic S000004402VIP1YLR410WverifiedProtein of unknown function probably involved in the functionof the cortical actin cytoskeleton; putativeortholog of S. pombe asp1+ 0.004150.10814&radic&radic S000003108YGL140CUncharacterizedHypothetical protein 0.004140.10771&radic S000006161HSP82YPL240CverifiedCytoplasmic chaperone (Hsp90 family) required for pheromonesignaling and negative regulation of Hsf1p;docks with the mitochondrial import receptorTom70p for preprotein delivery; interacts withco-chaperones Cns1p, Cpr6p, Cpr7p, and Sti1p 0.004120.10731 S000000013NTG1YAL015CverifiedDNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involvedin base excision repair, localizes to thenucleus and mitochondrion 0.004120.10731&radic&radic S000000756ECM10YEL030WverifiedHeat shock protein of the Hsp70 family, localized inmitochondrial nucleoids, plays a role inprotein translocation, interacts with Mge1p inan ATP-dependent manner; overexpression inducesextensive mitochondrial DNA aggregations 0.004130.10731&radic&radic S000005012FKH2YNL068CverifiedForkhead family transcription factor with a major role in theexpression of G2/M phase genes; positivelyregulates transcriptional elongation; negativerole in chromatin silencing at HML and HMR;substrate of the Cdc28p/Clb5p kinase 0.004120.10731 S000001133MSR1YHR091CverifiedMitochondrial arginyl-tRNA synthetase 0.004120.1072&radic S000002865TOM1YDR457WverifiedE3 ubiquitin ligase of the hect-domain class; has a role inmRNA export from the nucleus and may regulatetranscriptional coactivators 0.004120.1072 S000001780SIS2YKR072CverifiedNegative regulatory subunit of the protein phosphatase 1 Ppz1p;involved in ion homeostasis and cell cycleprogression 0.004120.1072&radic S000000312YBR108WUncharacterizedProtein interacting with Rsv167p 0.004120.1072 S000000056BDH1YAL060WverifiedNAD-dependent (2R,3R)-2,3-butanediol dehydrogenase, azinc-containing medium-chain alcoholdehydrogenase, produces 2,3-butanediol fromacetoin during fermentation and allows using2,3-butanediol as a carbon source duringaerobic growth 0.004110.10614&radic&radic&radic S000004663SEN15YMR059WverifiedSubunit of the tRNA splicing endonuclease, which is composed ofSen2p, Sen15p, Sen34p, and Sen54p 0.004120.10614 S000001858RPO41YFL036WverifiedMitochondrial RNA polymerase; single subunit enzyme similar tothose of T3 and T7 bacteriophages; requires aspecificity subunit encoded by MTF1 forpromoter recognition 0.004090.10614&radic