Yfunc lets you browse current and predicted gene functions in yeast

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Prediction of GO:0031499 "TRAMP complex"

GO branch: CC
Number of currently annotated genes: 4

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest Ho:S000001341Ho:S000002334Giaever:5-fluorouracil_76.9uMHo:S000005475Harbison:MSS11_BUT14TAP:36TAP:129Huh:nucleusTAP:123Harbison:FHL1_H2O2Hi S000001341AIR1YIL079CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p to regulate methylationof Npl3p, which modulates Npl3p function inmRNA processing and export; has similarity toAir2p &radic0.269780.91923&radic&radic&radic&radic S000002334AIR2YDL175CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p; may regulatemethylation of Npl3p, which modulates Npl3pfunction in mRNA processing and export; hassimilarity to Air1p &radic0.214190.88372&radic&radic&radic S000005243TRF5YNL299WverifiedPoly (A) polymerase involved in nuclear RNA quality controlbased on: homology with Trf4p, geneticinteractions with TRF4 mutants, physicalinteraction with Mtr4p (TRAMP subunit), and bydirect assay; disputed role as a sigma DNApolymerase 0.200710.86233 S000003586MTR4YJL050WverifiedDead-box family ATP dependent helicase required for mRNA exportfrom the nucleus; co-factor of the exosomecomplex, required for 3' end formation of 5.8SrRNA &radic0.054820.69718&radic&radic&radic&radic&radic S000005475PAP2YOL115WverifiedCatalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), anuclear poly (A) polymerase complex involved inRNA quality control; catalyzes polyadenylationof unmodified tRNAs, and snoRNA and rRNAprecursors; disputed role as a DNA polymerase &radic0.050970.68921&radic&radic&radic S000006111NAB3YPL190CverifiedSingle stranded DNA binding protein; acidic ribonucleoprotein;required for termination of non-poly(A)transcripts and efficient splicing; interactswith Nrd1p 0.027160.54581&radic&radic S000002840NPL3YDR432WverifiedRNA-binding protein that carries poly(A)+ mRNA from the nucleusinto the cytoplasm; phosphorylation by Sky1p inthe cytoplasm may promote release of mRNAs 0.016890.43539&radic&radic&radic S000005206POL2YNL262WverifiedCatalytic subunit of DNA polymerase epsilon, one of the majorchromosomal DNA replication polymerasescharacterized by processivity and proofreadingexonuclease activity; also involved in DNAsynthesis during DNA repair 0.014270.39437&radic S000003163GCN1YGL195WverifiedPositive regulator of the Gcn2p kinase activity, forms acomplex with Gcn20p; proposed to stimulateGcn2p activation by an uncharged tRNA 0.011230.34205 S000005730DED1YOR204WverifiedATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, requiredfor translation initiation of all yeast mRNAs;mutations in human DEAD-box DBY are a frequentcause of male infertility 0.004890.18423 S000005366TOP1YOL006CverifiedTopoisomerase I, nuclear enzyme that relieves torsional strainin DNA by cleaving and re-sealing thephosphodiester backbone; relaxes bothpositively and negatively supercoiled DNA;functions in replication, transcription, andrecombination 0.004720.16905&radic S000000631RRP43YCR035CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp41p, Rrp42p,Rrp4p and Dis3p; required for efficientmaturation of 5.8S, 18S and 25S rRNA 0.004350.15028&radic&radic S000002789YRA1YDR381WverifiedNuclear protein that binds to RNA and to Mex67p, required forexport of poly(A)+ mRNA from the nucleus;member of the REF (RNA and export factorbinding proteins) family; another familymember, Yra2p, can substitute for Yra1pfunction 0.004030.14357&radic S000006067NOP53YPL146CverifiedNucleolar protein; involved in biogenesis of the 60S subunit ofthe ribosome; interacts with rRNA processingfactors Cbf5p and Nop2p; null mutant is viablebut growth is severely impaired 0.003610.13385&radic S000005195NRD1YNL251CverifiedRNA-binding protein that interacts with the C-terminal domainof the RNA polymerase II large subunit(Rpo21p), required for transcriptiontermination and 3' end maturation ofnonpolyadenylated RNAs 0.003630.13385&radic&radic S000004520IMD4YML056CverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 0.003530.13299 S000003088PRP43YGL120CverifiedRNA helicase in the DEAH-box family, functions in both RNApolymerase I and polymerase II transcriptmetabolism, involved in release of thelariat-intron from the spliceosome 0.003370.12735 S000000238HMT1YBR034CverifiedNuclear SAM-dependent mono- and asymmetric argininedimethylating methyltransferase that modifieshnRNPs, including Npl3p and Hrp1p, thusfacilitating nuclear export of these proteins;required for viability of npl3 mutants 0.003250.11795&radic S000004470SPT5YML010WverifiedProtein that forms a complex with Spt4p and mediates bothactivation and inhibition of transcriptionelongation; Spt4p-Spt5p complex also plays arole in pre-mRNA processing 0.002390.09298&radic S000003336SRB5YGR104CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation; involved intelomere maintenance 0.002270.09242&radic S000001756NAP1YKR048CverifiedProtein that interacts with mitotic cyclin Clb2p; required forthe regulation of microtubule dynamics duringmitosis; controls bud morphogenesis; involvedin the transport of H2A and H2B histones to thenucleus 0.002270.09242 S000004732STO1YMR125WverifiedLarge subunit of the nuclear mRNA cap-binding protein complex,interacts with Npl3p to carry nuclear poly(A)+mRNA to cytoplasm; also involved in nuclearmRNA degradation and telomere maintenance;orthologous to mammalian CBP80 0.002270.09242&radic&radic S000004424IMD3YLR432WverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 0.002260.09188 S000001387KGD1YIL125WverifiedComponent of the mitochondrial alpha-ketoglutaratedehydrogenase complex, which catalyzes a keystep in the tricarboxylic acid (TCA) cycle, theoxidative decarboxylation ofalpha-ketoglutarate to form succinyl-CoA 0.00220.09063 S000002430SES1YDR023WverifiedCytosolic seryl-tRNA synthetase, class II aminoacyl-tRNAsynthetase that aminoacylates tRNA(Ser),displays tRNA-dependent amino acid recognitionwhich enhances discrimination of the serinesubstrate, interacts with peroxin Pex21p 0.00220.09063 S000000968DNF1YER166WverifiedAminophospholipid translocase (flippase) that localizesprimarily to the plasma membrane; contributesto endocytosis, protein transport and cellpolarity; type 4 P-type ATPase 0.00210.08975 S000005738STE4YOR212WverifiedG protein beta subunit, forms a dimer with Ste18p to activatethe mating signaling pathway, forms aheterotrimer with Gpa1p and Ste18p to dampensignaling; may recruit Rho1p to the polarizedgrowth site during mating; contains WD40repeats 0.00210.08975 S000006395QCR2YPR191WverifiedSubunit 2 of the ubiquinol cytochrome-c reductase complex,which is a component of the mitochondrial innermembrane electron transport chain;transcription is regulated by Hap1p,Hap2p/Hap3p, and heme 0.002110.08975 S000002555KGD2YDR148CverifiedDihydrolipoyl transsuccinylase, a component of themitochondrial alpha-ketoglutarate dehydrogenasecomplex, which catalyzes a step in thetricarboxylic acid (TCA) cycle, the oxidativedecarboxylation of alpha-ketoglutarate tosuccinyl-CoA 0.002030.08748 S000005133SRP1YNL189WverifiedKaryopherin alpha homolog, forms a dimer with karyopherin betaKap95p to mediate import of nuclear proteins,binds the nuclear localization signal of thesubstrate during import; may also play a rolein regulation of protein degradation 0.002030.08748 S000004949HRB1YNL004WverifiedPoly(A+) RNA-binding protein, involved in the export of mRNAsfrom the nucleus to the cytoplasm; similar toGbp2p and Npl3p 0.002030.08748&radic S000001927SMC2YFR031CverifiedComponent of the condensin complex, essential SMC chromosomalATPase family member that forms a complex withSmc4p to form the active ATPase; Smc2p/Smc4pcomplex binds DNA, possibly in the cleft formedby the coiled-coil of the folded dimer 0.002030.08748&radic S000005480RPL18AYOL120CverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl18Bp and has similarity to ratL18 ribosomal protein; intron of RPL18Apre-mRNA forms stem-loop structures that are atarget for Rnt1p cleavage leading todegradation 0.002030.08748 S000004918ADH2YMR303CverifiedGlucose-repressible alcohol dehydrogenase II, catalyzes theconversion of ethanol to acetaldehyde; involvedin the production of certain carboxylateesters; regulated by ADR1 0.002030.08748 S000001886SMC1YFL008WverifiedSubunit of the multiprotein cohesin complex, essential proteininvolved in chromosome segregation and indouble-strand DNA break repair; SMC chromosomalATPase family member, binds DNA with apreference for DNA with secondary structure 0.002010.08499&radic&radic S000004925PSE1YMR308CverifiedKaryopherin/importin that interacts with the nuclear porecomplex; acts as the nuclear import receptorfor specific proteins, including Pdr1p, Yap1p,Ste12p, and Aft1p 0.002020.08499&radic S000000455MRPS5YBR251WverifiedMitochondrial ribosomal protein of the small subunit 0.002010.08499&radic S000002688RRP45YDR280WverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex 0.002010.08499&radic S000004903HAS1YMR290CverifiedATP-dependent RNA helicase; localizes to both the nuclearperiphery and nucleolus; highly enriched innuclear pore complex fractions; constituent of66S pre-ribosomal particles 0.001950.08049 S000003397MRPS35YGR165WverifiedMitochondrial ribosomal protein of the small subunit 0.00190.08049 S000004920UBP15YMR304WverifiedUbiquitin-specific protease that may play a role in ubiquitinprecursor processing 0.001880.08049&radic S000000967PAB1YER165WverifiedPoly(A) binding protein, part of the 3'-end RNA-processingcomplex, mediates interactions between the 5'cap structure and the 3' mRNA poly(A) tail,involved in control of poly(A) tail length,interacts with translation factor eIF-4G 0.001850.08049 S000004745PSO2YMR137CverifiedRequired for a post-incision step in the repair of DNA singleand double-strand breaks that result frominterstrand crosslinks produced by a variety ofmono- and bi-functional psoralen derivatives;induced by UV-irradiation 0.001880.08049&radic&radic S000002467MAK21YDR060WverifiedConstituent of 66S pre-ribosomal particles, required for large(60S) ribosomal subunit biogenesis; involved innuclear export of pre-ribosomes; required formaintenance of dsRNA virus; homolog of humanCAATT-binding protein 0.001850.08049&radic S000001789RPF2YKR081CverifiedEssential protein involved in the processing of pre-rRNA andthe assembly of the 60S ribosomal subunit;interacts with ribosomal protein L11; localizespredominantly to the nucleolus; constituent of66S pre-ribosomal particles 0.001760.07682&radic S000005820RRS1YOR294WverifiedEssential protein that binds ribosomal protein L11 and isrequired for nuclear export of the 60Spre-ribosomal subunit during ribosomebiogenesis; mouse homolog shows alteredexpression in Huntington's disease model mice 0.001760.07682 S000002419RPL4BYDR012WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl4Ap and has similarity to E.coli L4 and rat L4 ribosomal proteins 0.001770.07682&radic S000003797HUL4YJR036CverifiedProtein with similarity to hect domain E3 ubiquitin-proteinligases, not essential for viability 0.001760.07682 S000006141RPL1AYPL220WverifiedN-terminally acetylated protein component of the large (60S)ribosomal subunit, nearly identical to Rpl1Bpand has similarity to E. coli L1 and rat L10aribosomal proteins; rpl1a rpl1b double nullmutation is lethal 0.001780.07682 S000005527RRP6YOR001WverifiedExonuclease component of the nuclear exosome; contributes tothe quality-control system that retains anddegrades aberrant mRNAs in the nucleus 0.001760.07682&radic&radic&radic S000001906UBP6YFR010WverifiedUbiquitin-specific protease situated in the base subcomplex ofthe 26S proteasome, releases free ubiquitinfrom branched polyubiquitin chains; deletioncauses hypersensitivity to cycloheximide andother toxic compounds 0.001770.07682&radic S000004187SIK1YLR197WverifiedEssential evolutionarily-conserved nucleolar protein componentof the box C/D snoRNP complexes that direct2'-O-methylation of pre-rRNA during itsmaturation; overexpression causes spindleorientation defects 0.00170.07353 S000005056DBP2YNL112WverifiedEssential ATP-dependent RNA helicase of the DEAD-box proteinfamily, involved in nonsense-mediated mRNAdecay and rRNA processing 0.001130.06147&radic S000004577ZDS2YML109WverifiedProtein that interacts with silencing proteins at the telomere,involved in transcriptional silencing; paralogof Zds1p 0.001140.06147 S000004886ZDS1YMR273CverifiedProtein that interacts with silencing proteins at the telomere,involved in transcriptional silencing; has arole in localization of Bcy1p, a regulatorysubunit of protein kinase A; implicated in mRNAnuclear export 0.001090.06147 S000004284GSP1YLR293CverifiedGTP binding protein (mammalian Ranp homolog) involved in themaintenance of nuclear organization, RNAprocessing and transport; regulated by Prp20p,Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p andKap95p; yeast Gsp2p homolog 0.001050.0572&radic S000004984BDP1YNL039WverifiedEssential subunit of RNA polymerase III transcription factor(TFIIIB), which is involved in transcription ofgenes encoding tRNAs, 5S rRNA, U6 snRNA, andother small RNAs 0.00070.04876&radic S000006177CLN2YPL256CverifiedG1 cyclin involved in regulation of the cell cycle; activatesCdc28p kinase to promote the G1 to S phasetransition; late G1 specific expression dependson transcription factor complexes, MBF(Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) 0.000670.04876&radic S000004682VPS20YMR077CverifiedMyristoylated subunit of ESCRTIII, the endosomal sortingcomplex required for transport of transmembraneproteins into the multivesicular body pathwayto the lysosomal/vacuolar lumen; cytoplasmicprotein recruited to endosomal membranes 0.000650.04876 S000000120NCL1YBL024WverifiedS-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase,methylates cytosine to m5C at several positionsin tRNAs and intron-containing pre-tRNAs;similar to Nop2p and human proliferationassociated nucleolar protein p120 0.000750.04876&radic S000006379DPB2YPR175WverifiedSecond largest subunit of DNA polymerase II (DNA polymeraseepsilon), required for normal yeast chromosomalreplication; expression peaks at the G1/S phaseboundary; potential Cdc28p substrate 0.000860.04876&radic S000003406CBP4YGR174CverifiedMitochondrial protein required for assembly of ubiquinolcytochrome-c reductase complex (cytochrome bc1complex); interacts with Cbp3p and function ispartially redundant with that of Cbp3p 0.000850.04876&radic S000000122LSM2YBL026WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.000780.04876&radic S000001073RRM3YHR031CverifiedDNA helicase involved in rDNA replication and Ty1transposition; relieves replication fork pausesat telomeric regions; structurally andfunctionally related to Pif1p 0.000710.04876&radic S000000039CDC24YAL041WverifiedGuanine nucleotide exchange factor (GEF or GDP-release factor)for Cdc42p; required for polarity establishmentand maintenance, and mutants have morphologicaldefects in bud formation and shmooing 0.000780.04876&radic S000002360TRM8YDL201WverifiedSubunit of a tRNA methyltransferase complex composed of Trm8pand Trm82p that catalyzes 7-methylguanosinemodification of tRNA 0.000750.04876&radic S000002847LRS4YDR439WverifiedProtein involved in rDNA silencing; positively chargedcoiled-coil protein with limited similarity tomyosin 0.000710.04876&radic S000003660LSM1YJL124CverifiedLsm (Like Sm) protein; forms heteroheptameric complex (withLsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p)involved in degradation of cytoplasmic mRNAs 0.000720.04876 S000005356YNR073CUncharacterizedHypothetical protein 0.00070.04876 S000000673PAT1YCR077CverifiedTopoisomerase II-associated deadenylation-dependentmRNA-decapping factor; also required forfaithful chromosome transmission, maintenanceof rDNA locus stability, and protection of mRNA3'-UTRs from trimming; functionally linked toPab1p 0.000780.04876 S000004181PEX13YLR191WverifiedIntegral peroxisomal membrane receptor for the PTS1 peroxisomalmatrix protein signal recognition factor Pex5p,required for the translocation of peroxisomalmatrix proteins, also interacts with Pex7p andPex14p, contains a C-terminal SH3 domain 0.000670.04876 S000004029RIC1YLR039CverifiedProtein involved in retrograde transport to the cis-Golginetwork; forms heterodimer with Rgp1p that actsas a GTP exchange factor for Ypt6p; involved intranscription of rRNA and ribosomal proteingenes 0.000680.04876 S000001238NVJ1YHR195WverifiedNuclear envelope protein that interacts with the vacuolarmembrane protein Vac8p to promote formation ofnucleus-vacuole junctions during piecemealmicroautophagy of the nucleus (PMN) 0.000650.04876&radic S000002544RGP1YDR137WverifiedSubunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) thatcatalyzes nucleotide exchange on Ypt6p 0.000640.04736 S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling 0.000640.04736&radic&radic S000002767VID21YDR359CverifiedComponent of the NuA4 histone acetyltransferase complex 0.000640.04736 S000000286UBC4YBR082CverifiedUbiquitin-conjugating enzyme that mediates degradation ofshort-lived and abnormal proteins; interactswith E3-CaM in ubiquitinating calmodulin;interacts with many SCF ubiquitin proteinligases; component of the cellular stressresponse 0.000630.04736&radic S000003746PEX2YJL210WverifiedRING-finger peroxin, peroxisomal membrane protein with aC-terminal zinc-binding RING domain, formsputative translocation subcomplex with Pex10pand Pex12p which functions in peroxisomalmatrix protein import 0.000570.04592 S000001508PAN3YKL025CverifiedEssential subunit of the Pan2p-Pan3p poly(A)-ribonucleasecomplex, which acts to control poly(A) taillength and regulate the stoichiometry andactivity of postreplication repair complexes 0.000530.04592&radic&radic S000001234CTF8YHR191CverifiedSubunit of a complex with Ctf18p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion 0.000590.04592 S000003063VPS45YGL095CverifiedProtein of the Sec1p/Munc-18 family, essential for vacuolarprotein sorting; required for the function ofPep12p and the early endosome/late Golgi SNARETlg2p; essential for fusion of Golgi-derivedvesicles with the prevacuolar compartment 0.000540.04592 S000006005BRO1YPL084WverifiedCytoplasmic class E vacuolar protein sorting (VPS) factor thatcoordinates deubiquitination in themultivesicular body (MVB) pathway by recruitingDoa4p to endosomes 0.000570.04592 S000003719MNN11YJL183WverifiedSubunit of a Golgi mannosyltransferase complex that alsocontains Anp1p, Mnn9p, Mnn10p, and Hoc1p, andmediates elongation of the polysaccharidemannan backbone; has homology to Mnn10p 0.000540.04592 S000000744EAF5YEL018WuncharacterizedEsa1p-associated factor, subunit of the NuA4 acetyltransferasecomplex 0.000540.04592&radic&radic S000000514STP22YCL008CverifiedComponent of the ESCRT-I complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; homologous to the mouse and humanTsg101 tumor susceptibility gene; mutantsexhibit a Class E Vps phenotype 0.000560.04592 S000005194RAD50YNL250WverifiedSubunit of MRX complex, with Mre11p and Xrs2p, involved inprocessing double-strand DNA breaks invegetative cells, initiation of meiotic DSBs,telomere maintenance, and nonhomologous endjoining 0.000590.04592&radic S000004837MRE11YMR224CverifiedSubunit of a complex with Rad50p and Xrs2p (RMX complex) thatfunctions in repair of DNA double-strand breaksand in telomere stability, exhibits nucleaseactivity that appears to be required for RMXfunction; widely conserved 0.000560.04592&radic S000004312MMS22YLR320WverifiedProtein involved in resistance to ionizing radiation; acts withMms1p in a repair pathway that may be involvedin resolving replication intermediates orpreventing the damage caused by blockedreplication forks 0.000570.04592 S000005831ISW2YOR304WverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPasecomponent that, with Itc1p, forms a complexrequired for repression of a-specific genes,INO1, and early meiotic genes during mitoticgrowth 0.000530.04592&radic&radic S000004683CTF18YMR078CverifiedSubunit of a complex with Ctf8p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion; may have overlappingfunctions with Rad24p in the DNA damagereplication checkpoint 0.000560.04592&radic S000004476TRM9YML014WverifiedtRNA methyltransferase, catalyzes the esterification ofmodified uridine nucleotides in tRNAs, creating5-methylcarbonylmethyluridine in tRNA(Arg3) and5-methylcarbonylmethyl-2-thiouridine intRNA(Glu); may have a role in stress response 0.000530.04592 S000004138PEP3YLR148WverifiedVacuolar peripheral membrane protein that promotes vesiculardocking/fusion reactions in conjunction withSNARE proteins, required for vacuolarbiogenesis, forms complex with Pep5p thatmediates protein transport to the vacuole 0.000530.04592 S000002905ITR1YDR497CverifiedMyo-inositol transporter with strong similarity to the minormyo-inositol transporter Itr2p, member of thesugar transporter superfamily; expression isrepressed by inositol and choline via Opi1p andderepressed via Ino2p and Ino4p 0.000550.04592&radic S000001596RAD27YKL113Cverified5' to 3' exonuclease, 5' flap endonuclease, required forOkazaki fragment processing and maturation aswell as for long-patch base-excision repair;member of the S. pombe RAD2/FEN1 family 0.000530.04592&radic S000003651ASF1YJL115WverifiedNucleosome assembly factor, involved in chromatin assembly anddisassembly, anti-silencing protein that causesderepression of silent loci when overexpressed 0.000530.04592&radic S000000602RVS161YCR009CverifiedAmphiphysin-like lipid raft protein; subunit of a complex(Rvs161p-Rvs167p) that regulates polarizationof the actin cytoskeleton, endocytosis, cellpolarity, cell fusion and viability followingstarvation or osmotic stress 0.000590.04592 S000004467ERG6YML008CverifiedDelta(24)-sterol C-methyltransferase, converts zymosterol tofecosterol in the ergosterol biosyntheticpathway by methylating position C-24; localizedto both lipid particles and mitochondrial outermembrane 0.000540.04592 S000002718SUM1YDR310CverifiedTranscriptional repressor required for mitotic repression ofmiddle sporulation-specific genes; involved intelomere maintenance, regulated by thepachytene checkpoint 0.000560.04592&radic S000003062PAN2YGL094CverifiedEssential subunit of the Pan2p-Pan3p poly(A)-ribonucleasecomplex, which acts to control poly(A) taillength and regulate the stoichiometry andactivity of postreplication repair complexes 0.000480.04467 S000004045SPT8YLR055CverifiedSubunit of the SAGA transcriptional regulatory complex but notpresent in SAGA-like complex SLIK/SALSA,required for SAGA-mediated inhibition at somepromoters 0.000480.04467&radic S000003095SOH1YGL127CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; involved in telomeremaintenance; conserved with other metazoanMED31 subunits 0.000450.04467&radic S000001111RRP4YHR069CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp41p, Rrp42p,Rrp43p and Dis3p 0.000460.04467&radic S000004252YPT6YLR262CverifiedGTPase, Ras-like GTP binding protein involved in the secretorypathway, required for fusion ofendosome-derived vesicles with the late Golgi,maturation of the vacuolar carboxypeptidase Y;has similarity to the human GTPase, Rab6 0.000480.04467 S000006082BEM4YPL161CverifiedProtein involved in establishment of cell polarity and budemergence; interacts with the Rho1p smallGTP-binding protein and with the Rho-typeGTPase Cdc42p; involved in maintenance ofproper telomere length 0.000490.04467&radic S000005187SLA2YNL243WverifiedTransmembrane actin-binding protein involved in membranecytoskeleton assembly and cell polarization;adaptor protein that links actin to clathrinand endocytosis; present in the actin corticalpatch of the emerging bud tip; dimer in vivo 0.000470.04467 S000004172SWI6YLR182WverifiedTranscription cofactor, forms complexes with DNA-bindingproteins Swi4p and Mbp1p to regulatetranscription at the G1/S transition; involvedin meiotic gene expression; localizationregulated by phosphorylation; potential Cdc28psubstrate 0.000490.04467&radic&radic S000004494RAD52YML032CverifiedProtein that stimulates strand exchange by facilitating Rad51pbinding to single-stranded DNA; annealscomplementary single-stranded DNA; involved inthe repair of double-strand breaks in DNAduring vegetative growth and meiosis 0.000530.04467&radic S000005606DIA2YOR080WverifiedOrigin-binding F-box protein that forms an SCF ubiquitin ligasecomplex with Skp1p and Cdc53p; plays a role inDNA replication, involved in invasive andpseudohyphal growth 0.000530.04467&radic&radic S000005028END3YNL084CverifiedEH domain-containing protein involved in endocytosis, actincytoskeletal organization and cell wallmorphogenesis; forms a complex with Sla1p andPan1p 0.000410.04058&radic&radic S000000913SWI4YER111CverifiedDNA binding component of the SBF complex (Swi4p-Swi6p), atranscriptional activator that in concert withMBF (Mbp1-Swi6p) regulates late G1-specifictranscription of targets including cyclins andgenes required for DNA synthesis and repair 0.000410.04058&radic S000003288RSC1YGR056WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; containstwo essential bromodomains, a bromo-adjacenthomology (BAH) domain, and an AT hook 0.000410.04058 S000001377NUP159YIL115CverifiedSubunit of the nuclear pore complex that is found exclusivelyon the cytoplasmic side, forms a subcomplexwith Nup82p and Nsp1p, required for mRNA export 0.00040.04058 S000000682CSM1YCR086WverifiedNucleolar protein that forms a complex with Lrs4p which bindsMam1p at kinetochores during meiosis I tomediate accurate chromosome segregation, may beinvolved in premeiotic DNA replication;possible role in telomere maintenance 0.000410.04058&radic&radic S000004415ATG17YLR423CverifiedProtein that interacts with and is required for activation ofApg1p protein kinase; involved in autophagy butnot in the Cvt (cytoplasm to vacuole targeting)pathway 0.00040.04058&radic S000004409VPS36YLR417WverifiedComponent of the ESCRT-II complex; contains the GLUE (GRAM LikeUbiquitin binding in EAP45) domain which isinvolved in interactions with ESCRT-I andubiquitin-dependent sorting of proteins intothe endosome 0.000410.04058&radic S000003121PEX14YGL153WverifiedPeroxisomal membrane protein that is a central component of theperoxisomal protein import machinery, interactswith PTS1 (Pex5p) and PTS2 (Pex7p) peroxisomalmatrix protein signal recognition factors andmembrane receptor Pex13p 0.000440.04058 S000005372HTZ1YOL012CverifiedHistone variant H2AZ, exchanged for histone H2A in nucleosomesby the SWR1 complex; involved intranscriptional regulation through preventionof the spread of silent heterochromatin 0.00040.04058&radic S000001790NUP133YKR082WverifiedSubunit of the Nup84p subcomplex of the nuclear pore complex(NPC), localizes to both sides of the NPC,required to establish a normalnucleocytoplasmic concentration gradient of theGTPase Gsp1p 0.00040.04058 S000000818BIM1YER016WverifiedMicrotubule-binding protein that together with Kar9p makes upthe cortical microtubule capture site anddelays the exit from mitosis when the spindleis oriented abnormally 0.000440.04058 S000004349RSC2YLR357WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; involvedin telomere maintenance 0.000410.04058&radic S000004844PEP5YMR231WverifiedPeripheral vacuolar membrane protein required for proteintrafficking and vacuole biogenesis; formscomplex with Pep3p that promotes vesiculardocking/fusion reactions in conjunction withSNARE proteins, also interacts with Pep7p 0.000440.04058 S000001123LRP1YHR081WverifiedSubstrate-specific nuclear cofactor for exosome activity in theprocessing of stable RNAs; required fortelomere length maintenance; homolog ofmammalian nuclear matrix protein C1D involvedin regulation of DNA repair and recombination 0.000440.04058 S000002536SAC6YDR129CverifiedFimbrin, actin-bundling protein; cooperates with Scp1p(calponin/transgelin) in the organization andmaintenance of the actin cytoskeleton 0.000450.04058 S000002160NHP10YDL002CverifiedProtein related to mammalian high mobility group proteins;likely component of the INO80 complex, which isan ATP-dependent chromatin-remodeling complex 0.000430.04058&radic S000000301VPS15YBR097WverifiedMyristoylated serine/threonine protein kinase involved invacuolar protein sorting; functions as amembrane-associated complex with Vps34p; activeform recruits Vps34p to the Golgi membrane;interacts with the GDP-bound form of Gpa1p 0.000410.04058 S000006305SNT309YPR101WverifiedComponent of NineTeen complex (NTC) containing Prp19p involvedin mRNA splicing, interacts physically andgenetically with Prp19p 0.000360.03849&radic S000005923SNF8YPL002CverifiedComponent of the ESCRT-II complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; appears to be functionallyrelated to SNF7; involved in glucosederepression 0.000380.03849 S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.000380.03849&radic&radic&radic S000005552BUB3YOR026WverifiedKinetochore checkpoint WD40 repeat protein that localizes tokinetochores during prophase and metaphase,delays anaphase in the presence of unattachedkinetochores; forms complexes with Mad1p-Bub1pand with Cdc20p, binds Mad2p and Mad3p 0.000380.03849&radic S000004075ARP6YLR085CverifiedActin-related protein that binds nucleosomes; a component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.000360.03849&radic S000001129YHR087WVerifiedProtein involved in RNA metabolism, one of two yeast homologs (with Sdo1p/Ylr022cp) of the human protein SBDS responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome, also conserved in Archaea 0.000350.03849&radic S000004363ROM2YLR371WverifiedGDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutationsare synthetically lethal with mutations inrom1, which also encodes a GEP 0.000380.03849 S000002545HPR1YDR138WverifiedSubunit of THO/TREX complexes that couple transcriptionelongation with mitotic recombination and withmRNA metabolism and export, subunit of an RNAPol II complex; regulates lifespan; involved intelomere maintenance; similar to Top1p 0.000350.03849&radic S000003863VPS25YJR102CverifiedComponent of the ESCRT-II complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome 0.000370.03849 S000005143GCR2YNL199CverifiedTranscriptional activator of genes involved in glycolysis;interacts and functions with the DNA-bindingprotein Gcr1p 0.000380.03849 S000005667ARP8YOR141CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes 0.000380.03849&radic S000005051YAF9YNL107WverifiedSubunit of both the NuA4 histone H4 acetyltransferase complexand the SWR1 complex, may function toantagonize silencing near telomeres; interactsdirectly with Swc4p, has homology to humanleukemogenic protein AF9, contains a YEATSdomain 0.000380.03849&radic S000003054MAD1YGL086WverifiedCoiled-coil protein involved in the spindle-assemblycheckpoint; phosphorylated by Mps1p uponcheckpoint activation which leads to inhibitionof the activity of the anaphase promotingcomplex; forms a complex with Mad2p 0.000350.03849&radic S000000435SWC5YBR231CuncharacterizedProtein of unknown function, component of the SWR1 complex,which exchanges histone variant H2AZ (Htz1p)for chromatin-bound histone H2A 0.000380.03849&radic S000004362ARC18YLR370CverifiedSubunit of the ARP2/3 complex, which is required for themotility and integrity of cortical actinpatches 0.000340.03846 S000005169CNM67YNL225CverifiedComponent of the spindle pole body outer plaque; required forspindle orientation and mitotic nuclearmigration 0.000340.03846 S000000322TEF2YBR118WverifiedTranslational elongation factor EF-1 alpha; also encoded byTEF1; functions in the binding reaction ofaminoacyl-tRNA (AA-tRNA) to ribosomes 0.000340.03846 S000004597MSC1YML128CverifiedProtein of unknown function; mutant is defective in directingmeiotic recombination events to homologouschromatids; the authentic, non-tagged proteinis detected in highly purified mitochondria inhigh-throughput studies 0.000310.03697 S000000770IES6YEL044WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.000310.03688&radic S000004329VRP1YLR337CverifiedProline-rich actin-associated protein involved in cytoskeletalorganization and cytokinesis; related tomammalian Wiskott-Aldrich syndrome protein(WASP)-interacting protein (WIP) 0.000270.03539 S000005199GIS2YNL255CverifiedProtein with seven cysteine-rich CCHC zinc-finger motifs,similar to human CNBP, proposed to be involvedin the RAS/cAMP signaling pathway 0.000250.03432 S000002495SLU7YDR088CverifiedRNA splicing factor, required for ATP-independent portion of2nd catalytic step of spliceosomal RNAsplicing; interacts with Prp18p; contains zincknuckle domain 0.000240.03236&radic S000004390SKI2YLR398CverifiedPutative RNA helicase, involved in exosome mediated 3' to 5'mRNA degradation and translation inhibition ofnon-poly(A) mRNAs; forms complex with Ski3p andSki8p; required for repressing propagation ofdsRNA viruses 0.000230.02934 S000004106MSL5YLR116WverifiedComponent of the commitment complex, which defines the firststep in the splicing pathway; essential proteinthat interacts with Mud2p and Prp40p, forming abridge between the intron ends; also involvedin nuclear retention of pre-mRNA 0.000230.02934&radic S000001542MPE1YKL059CverifiedEssential conserved subunit of CPF (cleavage andpolyadenylation factor), plays a role in 3' endformation of mRNA via the specific cleavage andpolyadenylation of pre-mRNA, contains aputative RNA-binding zinc knuckle motif 0.000220.02834&radic S000001710PAP1YKR002WverifiedPoly(A) polymerase, one of three factors required for mRNA3'-end polyadenylation, forms multiproteincomplex with polyadenylation factor I (PF I),also required for mRNA nuclear export; may alsopolyadenylate rRNAs 0.000220.02826&radic S000006311YTH1YPR107CverifiedEssential RNA-binding component of cleavage and polyadenylationfactor, contains five zinc fingers; requiredfor pre-mRNA 3'-end processing andpolyadenylation 0.00020.02778&radic S000000939YER137CUncharacterizedHypothetical protein 0.000180.02511 S000001725YKR017CUncharacterizedPutative protein of unknown function; contains a RING finger motif 0.000140.0215 S000003506TAF1YGR274CverifiedTFIID subunit (145 kDa), involved in RNA polymerase IItranscription initiation, has histoneacetyltransferase activity, involved inpromoter binding and G1/S progression 0.000130.02126&radic&radic S000001337RPN2YIL075CverifiedSubunit of the 26S proteasome, substrate of theN-acetyltransferase Nat1p 4e-050.00143&radic S000006205CIT3YPR001WverifiedCitrate synthase, catalyzes the condensation of acetyl coenzymeA and oxaloacetate to form citrate,mitochondrial isozyme involved in the TCA cycle 4e-050.00143 S000004898NGL2YMR285CverifiedProtein involved in 5.8S rRNA processing; Ccr4p-like RNaserequired for correct 3'-end formation of 5.8SrRNA at site E; similar to Ngl1p and Ngl3p 4e-050.00143&radic S000002279YDL121CUncharacterizedHypothetical protein 4e-050.00143 S000002287YDL129WUncharacterizedHypothetical protein 4e-050.00143&radic S000004110YPS1YLR120CverifiedAspartic protease, attached to the plasma membrane via aglycosylphosphatidylinositol (GPI) anchor 4e-050.00143 S000005090YNL146WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene 4e-050.00143 S000003432ELP2YGR200CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;target of Kluyveromyces lactis zymocin 4e-050.00143 S000005409GSH2YOL049WverifiedGlutathione synthetase, catalyzes the ATP-dependent synthesisof glutathione (GSH) fromgamma-glutamylcysteine and glycine; induced byoxidative stress and heat shock 4e-050.00143 S000000837EDC2YER035WverifiedRNA-binding protein, activates mRNA decapping directly bybinding to the mRNA substrate and enhancing theactivity of the decapping proteins Dcp1p andDcp2p 4e-050.00143&radic S000000989YER187WUncharacterizedHypothetical protein 4e-050.00143 S000003508RNH70YGR276Cverified3' exoribonuclease, required for 5S and tRNA-Arg3 maturation 4e-050.00143&radic S000003576NUP192YJL039CverifiedEssential structural subunit of the nuclear pore complex (NPC),localizes to the nuclear periphery of nuclearpores, homologous to human p205 4e-050.00143 S000000290IST2YBR086CverifiedPlasma membrane protein that may be involved in osmotolerance,localizes to the mother cell in small-buddedcells and to the bud in medium- andlarge-budded cells; mRNA is transported to thebud tip by an actomyosin-driven process 4e-050.00143 S000001198YSP1YHR155WuncharacterizedMitochondrial protein with a potential role in promotingmitochondrial fragmentation during programmedcell death in response to high levels ofalpha-factor mating pheromone or the drugamiodarone 4e-050.00143 S000002996SCW11YGL028CverifiedCell wall protein with similarity to glucanases; may play arole in conjugation during mating based on itsregulation by Ste12p 4e-050.00143&radic&radic S000000780RPL12AYEL054CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl12Bp; rpl12a rpl12b doublemutant exhibits slow growth and slowtranslation; has similarity to E. coli L11 andrat L12 ribosomal proteins 4e-050.00143 S000001776BET3YKR068CverifiedHydrophilic protein that acts in conjunction with SNAREproteins in targeting and fusion of ER to Golgitransport vesicles; component of the TRAPP(transport protein particle) complex 4e-050.00143 S000007611YJL062W-AUncharacterizedPutative protein of unknown function, identified based on comparison to related yeast species; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria 4e-050.00143 S000028576YMR230W-AUncharacterizedPutative protein of unknown function 4e-050.00143 S000001613SHE2YKL130CverifiedRNA-binding protein that binds specific mRNAs and interactswith She3p; part of the mRNA localizationmachinery that restricts accumulation ofcertain proteins to the bud 4e-050.00143&radic S000005041PHO23YNL097CverifiedProbable component of the Rpd3 histone deacetylase complex,involved in transcriptional regulation of PHO5;C-terminus has similarity to human candidatetumor suppressor p33(ING1) 4e-050.00143&radic S000005802CAF20YOR276WverifiedPhosphoprotein of the mRNA cap-binding complex involved intranslational control, repressor ofcap-dependent translation initiation, competeswith eIF4G for binding to eIF4E 4e-050.00143 S000004588YML119WUncharacterizedPutative protein of unknown funtion; YML119W is not an essential gene; potential Cdc28p substrate 4e-050.00143 S000000760HYP2YEL034WverifiedTranslation initiation factor eIF-5A, promotes formation of thefirst peptide bond; similar to and functionallyredundant with Anb1p; possible role intranslation elongation; undergoes an essentialhypusination modification 4e-050.00143 S000001152ERP5YHR110WverifiedProtein with similarity to Emp24p and Erv25p, member of the p24family involved in ER to Golgi transport 4e-050.00143 S000002291YDL133WUncharacterizedHypothetical protein 4e-050.00143 S000006091DAP1YPL170WverifiedHeme-binding protein involved in regulation of cytochrome P450protein Erg11p; damage response protein,related to mammalian membrane progesteronereceptors; mutations lead to defects intelomeres, mitochondria, and sterol synthesis 4e-050.00143 S000001453YIR014WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene 4e-050.00143 S000028588YPL038W-AUncharacterizedIdentified by fungal homology and RT-PCR 4e-050.00143 S000004313SFH1YLR321CverifiedSubunit of the RSC chromatin remodeling complex required forkinetochore function in chromosome segregation;essential gene required for cell cycleprogression; phosphorylated in the G1 phase ofthe cell cycle; Snf5p paralog 4e-050.00143&radic&radic S000004384YLR392CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR392C is not an essential gene 4e-050.00143 S000001953YFR057WUncharacterizedHypothetical protein 4e-050.00143 S000004430CAR2YLR438WverifiedL-ornithine transaminase (OTAse), catalyzes the second step ofarginine degradation, expression isdually-regulated by allophanate induction and aspecific arginine induction process; notnitrogen catabolite repression sensitive 4e-050.00143&radic S000003992NOC3YLR002CverifiedProtein that forms a nuclear complex with Noc2p that binds to66S ribosomal precursors to mediate theirintranuclear transport; also binds to chromatinto promote the association of DNA replicationfactors and replication initiation 4e-050.00143&radic S000005161YNL217WUncharacterizedHypothetical protein 4e-050.00143 S000001954MEI4YER044C-AverifiedMeiosis-specific protein involved in recombination; requiredfor chromosome synapsis; required forproduction of viable spores 4e-050.00143 S000000644ARE1YCR048WverifiedAcyl-CoA:sterol acyltransferase, isozyme of Are2p; endoplasmicreticulum enzyme that contributes the majorsterol esterification activity in the absenceof oxygen 4e-050.00143 S000000935GLC7YER133WverifiedCatalytic subunit of type 1 serine/threonine proteinphosphatase, involved in many processesincluding glycogen metabolism, sporulation, andmitosis; interacts with multiple regulatorysubunits; predominantly isolated with Sds22p 4e-050.00143&radic&radic S000003700TPK1YJL164CverifiedSubunit of cytoplasmic cAMP-dependent protein kinase, whichcontains redundant catalytic subunits Tpk1p,Tpk2p, and Tpk3p and regulatory subunit Bcy1p;promotes vegetative growth in response tonutrients; inhibits filamentous growth 4e-050.00143&radic S000000332ATG14YBR128CverifiedSubunit of an autophagy-specific phosphatidylinositol 3-kinasecomplex (with Vps34p, Vps15p, and Vps30p)required for organization of apre-autophagosomal structure; ATG14transcription is activated by Gln3p duringnitrogen starvation 4e-050.00143&radic S000005931RET3YPL010WverifiedZeta subunit of the coatomer complex (COPI), which coatsGolgi-derived transport vesicles; involved inretrograde transport between Golgi and ER 4e-050.00143 S000001805PCK1YKR097WverifiedPhosphoenolpyruvate carboxykinase, key enzyme ingluconeogenesis, catalyzes early reaction incarbohydrate biosynthesis, glucose repressestranscription and accelerates mRNA degradation,regulated by Mcm1p and Cat8p, located in thecytosol 4e-050.00143 S000004386CST9YLR394WverifiedSUMO E3 ligase; required for synaptonemal complex formation;localizes to synapsis initiation sites onmeiotic chromosomes; potential Cdc28p substrate 4e-050.00143 S000003642IME2YJL106WverifiedSerine/threonine protein kinase involved in activation ofmeiosis, associates with Ime1p and mediates itsstability, activates Ndt80p; IME2 expression ispositively regulated by Ime1p 4e-050.00143 S000002613MSC2YDR205WverifiedMember of the cation diffusion facilitator family, localizes tothe endoplasmic reticulum and nucleus;mutations affect the cellular distribution ofzinc and also confer defects in meioticrecombination between homologous chromatids 4e-050.00143 S000001897LOC1YFR001WverifiedNuclear protein involved in asymmetric localization of ASH1mRNA; binds double-stranded RNA in vitro;constituent of 66S pre-ribosomal particles 4e-050.00143&radic S000003324DBF2YGR092WverifiedSer/Thr kinase involved in transcription and stress response;functions as part of a network of genes in exitfrom mitosis; localization is cell cycleregulated; activated by Cdc15p during the exitfrom mitosis 4e-050.00143&radic S000005020MKS1YNL076WverifiedPleiotropic regulatory factor involved in Ras-CAMP and lysinebiosynthetic pathways and nitrogen regulation;involved in retrograde (RTG)mitochondria-to-nucleus signaling 4e-050.00143&radic S000000461POP4YBR257WverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends; binds to the RPR1 RNAsubunit in Rnase P 4e-050.00143&radic S000000262UBP14YBR058CverifiedUbiquitin-specific protease that specifically disassemblesunanchored ubiquitin chains; involved infructose-1,6-bisphosphatase (Fbp1p)degradation; similar to human isopeptidase T 4e-050.00143&radic S000005875PUT4YOR348CverifiedProline permease, required for high-affinity transport ofproline; also transports the toxic prolineanalog azetidine-2-carboxylate (AzC); PUT4transcription is repressed in ammonia-growncells 4e-050.00143 S000003196VID30YGL227WverifiedProtein involved in proteasome-dependent catabolite degradationof fructose-1,6-bisphosphatase (FBPase); shiftsthe balance of nitrogen metabolism toward theproduction of glutamate; localized to thenucleus and the cytoplasm 4e-050.00135&radic S000005401NOP12YOL041CverifiedNucleolar protein, required for pre-25S rRNA processing;contains an RNA recognition motif (RRM) and hassimilarity to Nop13p, Nsr1p, and putativeorthologs in Drosophila and S. pombe 4e-050.00135 S000001195SPO12YHR152WverifiedNucleolar protein of unknown function, positive regulator ofexit from mitosis; involved in regulating therelease of Cdc14p from the nucleolus in earlyanaphase; proposed to play similar role inmeiosis 4e-050.00135&radic S000002461CDC34YDR054CverifiedUbiquitin-conjugating enzyme or E2; together with Skp1p, Rbx1p,Cdc53p, and an F-box protein, forms aubiquitin-protein ligase called the SCF complexwhich regulates cell cycle progression bytargeting key substrates for degradation 4e-050.00135&radic&radic S000002216USO1YDL058WverifiedEssential protein involved in intracellular protein transport,coiled-coil protein necessary for transportfrom ER to Golgi; required for assembly of theER-to-Golgi SNARE complex 4e-050.00135&radic S000004832ESC1YMR219WverifiedProtein localized to the nuclear periphery, involved intelomeric silencing; interacts with PAD4-domainof Sir4p 4e-050.00135 S000001828YFL066CUncharacterizedHelicase-like protein encoded within the telomeric Y' element 4e-050.00135 S000003666URA2YJL130CverifiedBifunctional carbamoylphosphate synthetase (CPSase)-aspartatetranscarbamylase (ATCase), catalyzes the firsttwo enzymatic steps in the de novo biosynthesisof pyrimidines; both activities are subject tofeedback inhibition by UTP 4e-050.00135&radic S000004754TIF34YMR146CverifiedSubunit of the core complex of translation initiation factor3(eIF3), which is essential for translation 4e-050.00135 S000004487YML6YML025CverifiedMitochondrial ribosomal protein of the large subunit, hassimilarity to E. coli L4 ribosomal protein andhuman mitoribosomal MRP-L4 protein; essentialfor viability, unlike most other mitoribosomalproteins 4e-050.00135 S000003978YLL055WUncharacterizedPutative protein of unknown function with similarity to transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLL055W is not an essential gene 4e-050.00135 S000005384YOL024WUncharacterizedHypothetical protein 4e-050.00135&radic S000002315YDL156WUncharacterizedHypothetical protein 4e-050.00135&radic S000003773YJR012CUncharacterizedPutative protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W 4e-050.00135&radic S000001443DJP1YIR004WverifiedCytosolic J-domain-containing protein, required for peroxisomalprotein import and involved in peroxisomeassembly, homologous to E. coli DnaJ 4e-050.00135 S000002393GYP7YDL234CverifiedGTPase-activating protein for yeast Rab family membersincluding: Ypt7p (most effective), Ypt1p,Ypt31p, and Ypt32p (in vitro); involved invesicle mediated protein trafficking 4e-050.00135 S000001902YFR006WUncharacterizedPutative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene 4e-050.00135&radic S000002535YDR128WUncharacterizedHypothetical protein 4e-050.00135&radic S000001132YNG2YHR090CverifiedSubunit of the NuA4 histone acetyltransferase complex thatacetylates histone H4 and H2A; has similarityto the human tumor suppressor ING1 4e-050.00135&radic&radic S000000407COS111YBR203WverifiedProtein required for resistance to the antifungal drugciclopirox olamine; not related to thesubtelomerically-encoded COS family; theauthentic, non-tagged protein is detected inhighly purified mitochondria in high-throughputstudies 4e-050.00135 S000000559SPB1YCL054WverifiedAdoMet-dependent methyltransferase involved in rRNA processingand 60S ribosomal subunit maturation;methylates G2922 in the tRNA docking site ofthe large subunit rRNA and in the absence ofsnR52, U2921; suppressor of PAB1 mutants 4e-050.00135&radic&radic S000005335POP2YNR052CverifiedRNase of the DEDD superfamily, subunit of the Ccr4-Not complexthat mediates 3' to 5' mRNA deadenylation 4e-050.00135 S000001470DAL7YIR031CverifiedMalate synthase, role in allantoin degradation unknown;expression sensitive to nitrogen cataboliterepression and induced by allophanate, anintermediate in allantoin degradation 4e-050.00135 S000003707YJL171CVerifiedGPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein 4e-050.00135 S000003228YPS5YGL259WuncharacterizedProtein with similarity to GPI-anchored aspartic proteases suchas Yap1p and Yap3p 4e-050.00135 S000004644YMR041CUncharacterizedPutative protein of unknown function with similarity to aldo/keto reductases; YMR041C is not an essential gene 4e-050.00135 S000003170ARO8YGL202WverifiedAromatic aminotransferase, expression is regulated by generalcontrol of amino acid biosynthesis 4e-050.00135 S000003052GUP1YGL084CverifiedPlasma membrane protein with a possible role in proton symportof glycerol; member of the MBOAT family ofputative membrane-bound O-acyltransferases 4e-050.00135 S000005040RPS7BYNL096CverifiedProtein component of the small (40S) ribosomal subunit, nearlyidentical to Rps7Ap; interacts with Kti11p;deletion causes hypersensitivity to zymocin;has similarity to rat S7 and Xenopus S8ribosomal proteins 4e-050.00135 S000000112FUS3YBL016WverifiedMitogen-activated protein kinase involved in mating pheromoneresponse; activated by phosphorylation bySte7p; provides specificity during the matingvs. filamentous growth response byphosphorylating transcriptional and cytoplasmictargets 4e-050.00135&radic&radic S000005499CDC33YOL139CverifiedCytoplasmic mRNA cap binding protein; the eIF4E-cap complex isresponsible for mediating cap-dependent mRNAtranslation via interactions with thetranslation initiation factor eIF4G (Tif4631por Tif4632p) 4e-050.00135 S000003478BRF1YGR246CverifiedTFIIIB B-related factor, one of three subunits of RNApolymerase III transcription initiation factorTFIIIB, binds TFIIIC and TBP and recruits RNApol III to promoters, amino-terminal half ishomologous to TFIIB 4e-050.00135&radic S000001365DPH1YIL103WverifiedProtein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p,for synthesis of diphthamide, which is amodified histidine residue of translationelongation factor 2 (Eft1p or Eft2p); may actin a complex with Dph2p and Kti11p 4e-050.00135 S000003038RPB9YGL070CverifiedRNA polymerase II subunit B12.6; contacts DNA; mutations affecttranscription start site; involved in telomeremaintenance 4e-050.00135&radic S000004718MED11YMR112CverifiedEssential subunit of the RNA polymerase II mediator complex;associates with core polymerase subunits toform the RNA polymerase II holoenzyme 4e-050.00135&radic S000001672HYM1YKL189WverifiedComponent of the RAM signaling network that is involved inregulation of Ace2p activity and cellularmorphogenesis, interacts with Kic1p and Sog2p,localizes to sites of polarized growth duringbudding and during the mating response 4e-050.00135&radic S000001638RSM22YKL155CverifiedMitochondrial ribosomal protein of the small subunit 4e-050.00135&radic S000028827YGR035W-AUncharacterizedPutative protein of unknown function 4e-050.00135 S000006249MNI2YPR045CuncharacterizedDeletion mutant is synthetically lethal with MEN mutants 4e-050.00135&radic S000004267YSH1YLR277CverifiedPutative endonuclease, subunit of the mRNA cleavage andpolyadenylation specificity complex requiredfor 3' processing of mRNAs 4e-050.00135&radic&radic S000003293ADE6YGR061CverifiedFormylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzesa step in the 'de novo' purine nucleotidebiosynthetic pathway 4e-050.00135 S000001802RPL40BYKR094CverifiedFusion protein, identical to Rpl40Ap, that is cleaved to yieldubiquitin and a ribosomal protein of the large(60S) ribosomal subunit with similarity to ratL40; ubiquitin may facilitate assembly of theribosomal protein into ribosomes 4e-050.00135 S000002580ARG82YDR173CverifiedInositol polyphosphate multikinase (IPMK), sequentiallyphosphorylates Ins(1,4,5)P3 to formIns(1,3,4,5,6)P5; putative nuclear lipidinositol PI3-kinase; regulates arginine-,phosphate-, and nitrogen-responsive genes 4e-050.00135&radic S000001003PRS3YHL011Cverified5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involvedin nucleotide, histidine, and tryptophanbiosynthesis; one of a five related enzymes,which are active as heteromultimeric complexes 4e-050.00135 S000001200REC104YHR157WverifiedProtein involved in early stages of meiotic recombination;required for meiotic crossing over; forms acomplex with Rec102p and Spo11p necessaryduring the initiation of recombination 4e-050.00135 S000003030PYC1YGL062WverifiedPyruvate carboxylase isoform, cytoplasmic enzyme that convertspyruvate to oxaloacetate; highly similar toisoform Pyc2p but differentially regulated;mutations in the human homolog are associatedwith lactic acidosis 4e-050.00135 S000006352YPR148CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 4e-050.00135 S000005976LGE1YPL055CverifiedProtein of unknown function; null mutant forms abnormally largecells 4e-050.00135&radic S000005277SNZ2YNL333WverifiedMember of a stationary phase-induced gene family; transcriptionof SNZ2 is induced prior to diauxic shift, andalso in the absence of thiamin in aThi2p-dependent manner; forms a coregulatedgene pair with SNO2; interacts with Thi11p 4e-050.00135 S000001952IRC7YFR055WuncharacterizedPutative cystathionine beta-lyase; involved in copper ionhomeostasis and sulfur metabolism; null mutantdisplays increased levels of spontaneous Rad52foci 4e-050.00135 S000000859HMF1YER057CverifiedMember of the p14.5 protein family with similarity to Mmf1p,functionally complements Mmf1p function whentargeted to mitochondria; heat shock inducible;high-dosage growth inhibitor; forms ahomotrimer in vitro 4e-050.00135 S000005324COQ2YNR041CverifiedPara hydroxybenzoate: polyprenyl transferase, catalyzes thesecond step in ubiquinone (coenzyme Q)biosynthesis 4e-050.00135 S000005950SUV3YPL029WverifiedATP-dependent RNA helicase, component of the mitochondrialdegradosome along with the RNase Dss1p; thedegradosome associates with the ribosome andmediates turnover of aberrant or unprocessedRNAs 4e-050.00135 S000000208GPI18YBR004CverifiedFunctional ortholog of human PIG-V, which is amannosyltransferase that transfers the secondmannose in glycosylphosphatidylinositolbiosynthesis; the authentic, non-tagged proteinwas localized to mitochondria 4e-050.00135&radic S000003842EAF6YJR082CuncharacterizedEsa1p-associated factor, subunit of the NuA4 acetyltransferasecomplex 4e-050.00135&radic&radic S000005286RPC34YNR003CverifiedRNA polymerase III subunit C34; interacts with TFIIIB70 and isa key determinant in pol III recruitment by thepreinitiation complex 4e-050.00135 S000003661GCD14YJL125CverifiedSubunit of tRNA (1-methyladenosine) methyltransferase, withGcd10p, required for the modification of theadenine at position 58 in tRNAs, especiallytRNAi-Met; first identified as a negativeregulator of GCN4 expression 4e-050.00135&radic&radic S000003236PEX31YGR004WverifiedPeroxisomal integral membrane protein, involved in negativeregulation of peroxisome size; partiallyfunctionally redundant with Pex30p and Pex32p;probably acts at a step downstream of stepsmediated by Pex28p and Pex29p 4e-050.00135 S000001399TMA108YIL137CverifiedProtein that associates with ribosomes; putativemetalloprotease 4e-050.00135 S000007651YOS1YER074W-AverifiedIntegral membrane protein required for ER to Golgi transport;localized to the Golgi, the ER, and COPIIvesicles; interacts with Yip1p and Yif1p 4e-050.00135 S000004223EST1YLR233CverifiedTLC1 RNA-associated factor involved in telomere lengthregulation as the recruitment subunit of thetelomerase holoenzyme, has a possible role inactivating Est2p-TLC1-RNA bound to the telomere 4e-050.00135 S000003994THI73YLR004CuncharacterizedPutative plasma membrane permease proposed to be involved incarboxylic acid uptake and repressed bythiamine; substrate of Dbf2p/Mob1p kinase;transcription is altered if mitochondrialdysfunction occurs 4e-050.00135 S000003442YGR210CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 4e-050.00135 S000002353SNF3YDL194WverifiedPlasma membrane glucose sensor that regulates glucosetransport; has 12 predicted transmembranesegments; long cytoplasmic C-terminal tail isrequired for low glucose induction of hexosetransporter genes HXT2 and HXT4 4e-050.00135&radic S000002297RGT2YDL138WverifiedPlasma membrane glucose receptor, highly similar to Snf3p; bothRgt2p and Snf3p serve as transmembrane glucosesensors generating an intracellular signal thatinduces expression of glucose transporter (HXT)genes 4e-050.00135 S000000028SNC1YAL030WverifiedVesicle membrane receptor protein (v-SNARE) involved in thefusion between Golgi-derived secretory vesicleswith the plasma membrane; proposed to beinvolved in endocytosis; member of thesynaptobrevin/VAMP family of R-type v-SNAREproteins 4e-050.00135 S000005032TOP2YNL088WverifiedEssential type II topoisomerase, relieves torsional strain inDNA by cleaving and re-sealing thephosphodiester backbone of both positively andnegatively supercoiled DNA; cleavescomplementary strands; localizes to axial coresin meiosis 4e-050.00135&radic S000028848YMR175W-AUncharacterizedPutative protein of unknown function 4e-050.00135 S000003102PCL10YGL134WverifiedPho85p cyclin; recruits, activates, and targets Pho85pcyclin-dependent protein kinase to itssubstrate 4e-050.00135 S000001624SDH3YKL141WverifiedCytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p,Sdh3p, Sdh4p), which couples the oxidation ofsuccinate to the transfer of electrons toubiquinone 4e-050.00135 S000002998RPL30YGL030WverifiedProtein component of the large (60S) ribosomal subunit, hassimilarity to rat L30 ribosomal protein;involved in pre-rRNA processing in thenucleolus; autoregulates splicing of itstranscript 4e-050.00135 S000028542YDR246W-AUncharacterizedIdentified by fungal homology and RT-PCR 4e-050.00135 S000006252TAH18YPR048WverifiedProtein with a potential role in DNA replication; displayssynthetic lethal genetic interaction with thepol3-13 allele of POL3, which encodes DNApolymerase delta 4e-050.00135 S000001727IRS4YKR019CverifiedProtein involved in regulation of phosphatidylinositol4,5-bisphosphate concentrations; Irs4p andTax4p bind and activate the phosphatase Inp51p;mutation confers an increase in rDNA silencing 4e-050.00135 S000002186MPS1YDL028CverifiedDual-specificity kinase required for spindle pole body (SPB)duplication and spindle checkpoint function;substrates include SPB proteins Spc42p,Spc110p, and Spc98p, mitotic exit networkprotein Mob1p, and checkpoint protein Mad1p 4e-050.00135&radic S000000653PWP2YCR057CverifiedConserved 90S pre-ribosomal component essential for properendonucleolytic cleavage of the 35 S rRNAprecursor at A0, A1, and A2 sites; containseight WD-repeats; PWP2 deletion leads todefects in cell cycle and bud morphogenesis 4e-050.00135 S000004398RPL31BYLR406CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl31Ap and has similarity to ratL31 ribosomal protein; associates with thekaryopherin Sxm1p 4e-050.00135 S000001806UBP11YKR098CverifiedUbiquitin-specific protease that cleaves ubiquitin fromubiquitinated proteins 4e-050.00135 S000002878UGO1YDR470CverifiedProtein of unknown function; outer membrane component of themitochondrial fusion machinery; Ugo1p binddirectly to Fzo1p and Mgm1p and thereby linkthese two GTPases during mitochondrial fusion 4e-050.00135 S000003220HFM1YGL251CverifiedMeiosis specific DNA helicase involved in the conversion ofdouble-stranded breaks to later recombinationintermediates and in crossover control;catalyzes the unwinding of Holliday junctions;has ssDNA and dsDNA stimulated ATPase activity 4e-050.00135 S000002268TMA17YDL110CverifiedProtein of unknown function that associates with ribosomes 4e-050.00135&radic&radic S000003473YAP1802YGR241CverifiedProtein involved in clathrin cage assembly; binds Pan1p andclathrin; homologous to Yap1801p, member of theAP180 protein family 4e-050.00135 S000005685SME1YOR159CverifiedCore Sm protein Sm E; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm E 4e-050.00135 S000005657YOR131CUncharacterizedHypothetical protein 4e-050.00135&radic S000028667YKL096C-BUncharacterizedPutative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 4e-050.00135 S000004670SOV1YMR066WuncharacterizedMitochondrial protein of unknown function 4e-050.00135 S000000405DER1YBR201WverifiedEndoplasmic reticulum membrane protein, required forER-associated protein degradation of misfoldedor unassembled proteins; N- and C- terminiprotrude into the cytoplasm, has similarity toDfm1p 4e-050.00135&radic S000002700SRP101YDR292CverifiedSignal recognition particle (SRP) receptor - alpha subunit;contain GTPase domains; involved inSRP-dependent protein targeting; interacts withSRP102p 4e-050.00135&radic S000001174ECM14YHR132CverifiedPutative metalloprotease with similarity to the zinccarboxypeptidase family, required for normalcell wall assembly 4e-050.00135 S000003615PRY1YJL079CverifiedProtein of unknown function, has similarity to Pry2p and Pry3pand to the plant PR-1 class of pathogen relatedproteins 4e-050.00135 S000004142YLR152CUncharacterizedPutative protein of unknown function; YLR152C is not an essential gene 4e-050.00135 S000002153YBL113CUncharacterizedHelicase-like protein encoded within the telomeric Y' element 4e-050.00135 S000004239YEF3YLR249WverifiedTranslational elongation factor, stimulates the binding ofaminoacyl-tRNA (AA-tRNA) to ribosomes byreleasing EF-1 alpha from the ribosomalcomplex; contains two ABC cassettes; binds andhydrolyses ATP 4e-050.00135 S000001006YLF2YHL014CverifiedProtein of unknown function, has weak similarity to E. coliGTP-binding protein gtp1; the authentic,non-tagged protein is detected in highlypurified mitochondria in high-throughputstudies 4e-050.00132&radic S000004149YLR159WUncharacterizedNote: YLR156W, YLR159W, and YLR161W are identical. 4e-050.00132&radic S000000664ATG15YCR068WverifiedLipase, required for intravacuolar lysis of autophagic bodies;located in the endoplasmic reticulum membraneand targeted to intravacuolar vesicles duringautophagy via the multivesicular body (MVB)pathway 4e-050.00132&radic S000005417GPM3YOL056WverifiedHomolog of Gpm1p phosphoglycerate mutase, which converts3-phosphoglycerate to 2-phosphoglycerate inglycolysis; may be non-functional derivative ofa gene duplication event 4e-050.00132 S000002591PLP1YDR183WverifiedProtein with a possible role in folding of beta-tubulin; hassimilarity to phosducins, which are GTPaseinhibitors 4e-050.00132 S000002987CKB1YGL019WverifiedBeta regulatory subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKA2 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 4e-050.00132&radic S000004044OSW2YLR054CuncharacterizedProtein of unknown function proposed to be involved in theassembly of the spore wall 4e-050.00132&radic S000002554EKI1YDR147WverifiedEthanolamine kinase, primarily responsible forphosphatidylethanolamine synthesis via theCDP-ethanolamine pathway; also exhibits cholinekinase activity 4e-050.00132 S000000434OM14YBR230CverifiedIntegral mitochondrial outer membrane protein; abundance isdecreased in cells grown in glucose relative toother carbon sources; appears to contain 3alpha-helical transmembrane segments; ORFencodes a 97-basepair intron 4e-050.00132 S000001957SAE3YHR079C-AverifiedMeiosis specific protein involved in DMC1-dependent meioticrecombination, forms heterodimer with Mei5p;proposed to be an assembly factor for Dmc1p 4e-050.00132&radic S000005887PDE2YOR360CverifiedHigh-affinity cyclic AMP phosphodiesterase, component of thecAMP-dependent protein kinase signaling system,protects the cell from extracellular cAMP,contains readthrough motif surroundingtermination codon 4e-050.00132&radic S000005141WHI3YNL197CverifiedRNA binding protein that sequesters CLN3 mRNA in cytoplasmicfoci; cytoplasmic retention factor for Cdc28pand associated cyclins; regulates cell fate anddose-dependently regulates the critical cellsize required for passage through Start 4e-050.00132&radic&radic S000003985MHT1YLL062CverifiedS-methylmethionine-homocysteine methyltransferase, functionsalong with Sam4p in the conversion ofS-adenosylmethionine (AdoMet) to methionine tocontrol the methionine/AdoMet ratio 4e-050.00132 S000002610RAV2YDR202CverifiedSubunit of RAVE (Rav1p, Rav2p, Skp1p), a complex thatassociates with the V1 domain of the vacuolarmembrane (H+)-ATPase (V-ATPase) and promotesassembly and reassembly of the holoenzyme 4e-050.00132 S000003401PUS6YGR169CverifiedPseudouridine synthase responsible for modification ofcytoplasmic and mitochondrial tRNAs at position31; mutation of Asp168 to Ala abolishes enzymeactivity; not essential for viability 4e-050.00132 S000005207YIF1YNL263CverifiedIntegral membrane protein required for the fusion of ER-derivedCOPII transport vesicles with the Golgi;interacts with Yip1p and Yos1p; localizes tothe Golgi, the ER, and COPII vesicles 4e-050.00132 S000003321NNF2YGR089WuncharacterizedProtein that exhibits physical and genetic interactions withRpb8p, which is a subunit of RNA polymerases I,II, and III; computational analysis oflarge-scale protein-protein interaction datasuggests a role in chromosome segregation 4e-050.00132&radic S000005322ZRG17YNR039CverifiedEndoplasmic reticulum protein of unknown function,transcription is induced under conditions ofzinc deficiency; mutant phenotype suggests arole in uptake of zinc 4e-050.00132 S000001277BAR1YIL015WverifiedAspartyl protease secreted into the periplasmic space of matingtype a cells, helps cells find mating partners,cleaves and inactivates alpha factor allowingcells to recover from alpha-factor-induced cellcycle arrest 4e-050.00132 S000004643YET2YMR040WverifiedProtein of unknown function that may interact with ribosomes,based on co-purification experiments; homologof human BAP31 protein 4e-050.00132 S000004296STT4YLR305CverifiedPhosphatidylinositol-4-kinase that functions in the Pkc1pprotein kinase pathway; required for normalvacuole morphology, cell wall integrity, andactin cytoskeleton organization 4e-050.00132&radic S000001899YPI1YFR003CverifiedInhibitor of the type I protein phosphatase Glc7p, which isinvolved in regulation of a variety ofmetabolic processes; overproduction causesdecreased cellular content of glycogen 4e-050.00132 S000006188ACM1YPL267WverifiedCell cycle regulated protein of unknown function; associatedwith Cdh1p and may supress theAPC/C[Cdh1]-mediated proteolysis of mitoticcyclins 4e-050.00132 S000003053YGL085WUncharacterizedPutative protein of unknown function, has homology to Staphylococcus aureus nuclease; green fluorescent protein (GFP)-fusion protein localizes to mitochondria 4e-050.00132 S000003807TAH11YJR046WverifiedDNA replication licensing factor, required for pre-replicationcomplex assembly 4e-050.00132&radic S000028672YLL066W-BUncharacterizedDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data 4e-050.00132 S000028683YLR406C-AUncharacterizedPutative protein of unknown function 4e-050.00132 S000003521MAL11YGR289CverifiedMaltose permease, inducible high-affinity maltose transporter(alpha-glucoside transporter); encoded in theMAL1 complex locus; member of the 12transmembrane domain superfamily of sugartransporters 4e-050.00132 S000006138BMS1YPL217CverifiedEssential conserved nucleolar GTP-binding protein required forsynthesis of 40S ribosomal subunits and forprocessing of the 35S pre-rRNA at sites A0, A1,and A2; interacts with Rcl1p, has similarity toTsr1p 4e-050.00132 S000004825EFR3YMR212CverifiedNon-essential protein of unknown function; exhibits syntheticlethal genetic interactions with PHO85; theauthentic, non-tagged protein is detected inhighly purified mitochondria in high-throughputstudies 4e-050.00132 S000001278SNL1YIL016WverifiedProtein of unknown function proposed to be involved in nuclearpore complex biogenesis and maintenance as wellas protein folding; has similarity to themammalian BAG-1 protein 4e-050.00132 S000000045SPC72YAL047CverifiedComponent of the cytoplasmic Tub4p (gamma-tubulin) complex,binds spindle pole bodies and links them tomicrotubules; has roles in astral microtubuleformation and stabilization 4e-050.00132 S000003130SUT1YGL162WverifiedTranscription factor of the Zn[II]2Cys6 family involved insterol uptake; involved in induction of hypoxicgene expression 4e-050.00132&radic S000006373JIP5YPR169WuncharacterizedNucleolar protein of unknown function, exhibits a physicalinteraction with Bre1p 4e-050.00132&radic&radic&radic S000006156RVB2YPL235WverifiedEssential protein involved in transcription regulation;component of chromatin remodeling complexes;required for assembly and function of the INO80complex; member of the RUVB-like protein family 4e-050.00132 S000000471REI1YBR267WverifiedCytoplasmic pre-60S factor; required for the correct recyclingof shuttling factors Alb1, Arx1 and Tif6 at theend of the ribosomal large subunit biogenesis;involved in bud growth in the mitotic signalingnetwork 4e-050.00132 S000028510SUS1YBR111W-AverifiedProtein involved in mRNA export coupled transcriptionactivation; component of the SAGA histoneacetylase complex 4e-050.00132 S000003699YJL163CUncharacterizedHypothetical protein 4e-050.00132&radic&radic S000000452HIS7YBR248CverifiedImidazole glycerol phosphate synthase (glutamineamidotransferase:cyclase), catalyzes the fifthand sixth steps of histidine biosynthesis andalso produces 5-aminoimidazole-4-carboxamideribotide (AICAR), a purine precursor 4e-050.00132&radic S000002974PMC1YGL006WverifiedVacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ions; prevents growth inhibition by activationof calcineurin in the presence of elevatedconcentrations of calcium; similar to mammalianPMCA1a 4e-050.00132 S000003295SPT4YGR063CverifiedProtein that forms a complex with Spt5p and mediates bothactivation and inhibition of transcriptionelongation, and plays a role in pre-mRNAprocessing; in addition, Spt4p is involved inkinetochore function and gene silencing 4e-050.00132&radic S000002448RSM10YDR041WverifiedMitochondrial ribosomal protein of the small subunit, hassimilarity to E. coli S10 ribosomal protein;essential for viability, unlike most othermitoribosomal proteins 4e-050.00132&radic&radic S000004568CUE4YML101CuncharacterizedProtein of unknown function; has a CUE domain that bindsubiquitin, which may facilitate intramolecularmonoubiquitination 4e-050.00132 S000001709VPS1YKR001CverifiedGTPase required for vacuolar protein sorting, functions inactin cytoskeleton organization via itsinteraction with Sla1p; required for lateGolgi-retention of some proteins includingKex2p; involved in regulating peroxisomebiogenesis 4e-050.00132 S000001535ASK1YKL052CverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; phosphorylated duringthe cell cycle by cyclin-dependent kinases 4e-050.00132 S000000171SSA3YBL075CverifiedATPase involved in protein folding and the response to stress;plays a role in SRP-dependent cotranslationalprotein-membrane targeting and translocation;member of the heat shock protein 70 (HSP70)family; localized to the cytoplasm 4e-050.00132 S000007255TIM11YDR322C-AverifiedSubunit e of mitochondrial F1F0-ATPase, which is a large,evolutionarily conserved enzyme complexrequired for ATP synthesis; essential for thedimeric state of ATP synthase 4e-050.00132 S000028692YMR105W-AUncharacterizedPutative protein of unknown function 4e-050.00132 S000001079PUT2YHR037WverifiedDelta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encodedmitochondrial protein involved in utilizationof proline as sole nitrogen source; deficiencyof the human homolog causes HPII, an autosomalrecessive inborn error of metabolism 4e-050.00132 S000001569SRX1YKL086WverifiedSulfiredoxin, contributes to oxidative stress resistance byreducing cysteine-sulfinic acid groups in theperoxiredoxins Tsa1p and Ahp1p that are formedupon exposure to oxidants; conserved in highereukaryotes 4e-050.00132&radic S000005399RPP2AYOL039WverifiedRibosomal protein P2 alpha, a component of the ribosomal stalk,which is involved in the interaction betweentranslational elongation factors and theribosome; regulates the accumulation of P1(Rpp1Ap and Rpp1Bp) in the cytoplasm 4e-050.00132 S000000703RDS1YCR106WverifiedZinc cluster protein involved in conferring resistance tocycloheximide 4e-050.00132 S000028845YLR361C-AUncharacterizedPutative protein of unknown function 4e-050.00132 S000005160RAP1YNL216WverifiedDNA-binding protein involved in either activation or repressionof transcription, depending on binding sitecontext; also binds telomere sequences andplays a role in telomeric position effect(silencing) and telomere structure 4e-050.00132&radic S000028513YJR112W-AUncharacterizedPutative protein of unknown function; identified based on homology to Ashbya gossypii 4e-050.00132 S000002736SKP1YDR328CverifiedEvolutionarily conserved kinetochore protein that is part ofmultiple protein complexes, including the SCFubiquitin ligase complex, the CBF3 complex thatbinds centromeric DNA, and the RAVE complexthat regulates assembly of the V-ATPase 4e-050.00132&radic S000001415RRD1YIL153WverifiedActivator of the phosphotyrosyl phosphatase activity of PP2A;regulates G1 phase progression, the G2/M phasetransition, microtubule dynamics, theosmoresponse, bud morphogenesis and DNA repair;subunit of the Tap42p-Sit4p-Rrd1p complex 4e-050.00132&radic S000002985ATE1YGL017WverifiedArginyl-tRNA-protein transferase, catalyzes post-translationalconjugation of arginine to the amino termini ofacceptor proteins which are then subject todegradation via the N-end rule pathway 4e-050.00132 S000005089MFA2YNL145WverifiedMating pheromone a-factor, made by a cells; interacts withalpha cells to induce cell cycle arrest andother responses leading to mating; biogenesisinvolves C-terminal modification, N-terminalproteolysis, and export; also encoded by MFA1 4e-050.00132 S000002955YEL076C-AUncharacterizedHypothetical protein 4e-050.00132 S000005382YOL022CUncharacterizedProtein required for cell viability 4e-050.00132 S000005076KRE33YNL132WverifiedEssential protein of unknown function; heterozygous mutantshows haploinsufficiency in K1 killer toxinresistance 4e-050.00132 S000001925PTR3YFR029WverifiedComponent of the SPS plasma membrane amino acid sensor system(Ssy1p-Ptr3p-Ssy5p), which senses externalamino acid concentration and transmitsintracellular signals that result in regulationof expression of amino acid permease genes 4e-050.00132 S000000986YER184CUncharacterizedHypothetical protein 4e-050.00132 S000002400YDL241WUncharacterizedHypothetical protein 4e-050.00132 S000001751YKR043CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 4e-050.00132&radic S000002785ATP17YDR377WverifiedSubunit f of the F0 sector of mitochondrial F1F0 ATP synthase,which is a large, evolutionarily conservedenzyme complex required for ATP synthesis 4e-050.00132 S000005929CHL1YPL008WverifiedConserved nuclear protein required to establishsister-chromatid pairing during S-phase,probable DNA helicase with similarity to humanBACH1, which associates with tumor suppressorBRCA1; associates with acetyltransferase Ctf7p 4e-050.00132&radic S000006074RAD53YPL153CverifiedProtein kinase, required for cell-cycle arrest in response toDNA damage; activated by transautophosphorylation when interacting withhyperphosphorylated Rad9p; also interacts withARS1 and plays a role in initiation of DNAreplication 4e-050.00132&radic S000005973OAZ1YPL052WverifiedRegulator of ornithine decarboxylase (Spe1p), antizyme thatbinds to Spe1p to regulateubiquitin-independent degradation; ribosomalframeshifting during synthesis of Oaz1p and itsubiquitin-mediated degradation are bothpolyamine-regulated 4e-050.00132 S000004074RAX2YLR084CverifiedN-glycosylated protein involved in the maintenance of bud siteselection during bipolar budding; localizationrequires Rax1p 4e-050.00132 S000001043OSH7YHR001WverifiedMember of an oxysterol-binding protein family with sevenmembers in S. cerevisiae; family members haveoverlapping, redundant functions in sterolmetabolism and collectively perform a functionessential for viability 4e-050.00132 S000001679YKT6YKL196CverifiedVesicle membrane protein (v-SNARE) with acyltransferaseactivity; involved in trafficking to and withinthe Golgi, endocytic trafficking to thevacuole, and vacuolar fusion; membranelocalization due to prenylation at thecarboxy-terminus 4e-050.00132 S000000745MMS21YEL019CverifiedSUMO ligase involved in chromosomal organization and DNArepair; essential subunit of theMms21-Smc5-Smc6 complex; mutants are sensitiveto methyl methanesulfonate and show increasedspontaneous mutation and mitotic recombination 4e-050.00132&radic&radic S000004177SKG3YLR187WuncharacterizedProtein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to the cellperiphery, cytoplasm, bud, and bud neck;potential Cdc28p substrate; similar to Caf120pand Skg4p 4e-050.00132 S000003421CRH1YGR189CverifiedPutative glycosidase of the cell wall, may have a role in cellwall architecture 4e-050.00132 S000006015SEC62YPL094CverifiedEssential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p andSec72p); with Sec61 complex, Kar2p/BiP andLhs1p forms a channel competent forSRP-dependent and post-translationalSRP-independent protein targeting and importinto the ER 4e-050.00132 S000001285YKE4YIL023CverifiedZinc transporter; localizes to the ER; null mutant is sensitiveto calcofluor white, leads to zinc accumulationin cytosol; ortholog of the mouse KE4 andmember of the ZIP (ZRT, IRT-like Protein)family 4e-050.00132 S000001087YHR045WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum 4e-050.00132&radic S000005181YTP1YNL237WverifiedProbable type-III integral membrane protein of unknownfunction, has regions of similarity tomitochondrial electron transport proteins 4e-050.00132 S000002294RDI1YDL135CverifiedRho GDP dissociation inhibitor involved in the localization andregulation of Cdc42p 4e-050.00132&radic S000007526YOR396WUncharacterizedHypothetical protein 4e-050.00132 S000006050TAF14YPL129WverifiedSubunit (30 kDa) of TFIID, TFIIF, and SWI/SNF complexes,involved in RNA polymerase II transcriptioninitiation and in chromatin modification,contains a YEATS domain 4e-050.00132&radic S000002737PEX3YDR329CverifiedPeroxisomal membrane protein (PMP) required to recruit Pex19pchaperone to peroxisomes; plays selective,essential, direct role in PMP import as adocking factor for Pex19p 4e-050.00132 S000002402AAD4YDL243CverifiedPutative aryl-alcohol dehydrogenase with similarity to P.chrysosporium aryl-alcohol dehydrogenase,involved in the oxidative stress response 4e-050.00132 S000002432RPS11AYDR025WverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps11Bp and has similarity to E.coli S17 and rat S11 ribosomal proteins 4e-050.00132 S000000464RGD1YBR260CverifiedGTPase-activating protein (RhoGAP) for Rho3p and Rho4p,possibly involved in control of actincytoskeleton organization 4e-050.00132 S000001351YIL089WUncharacterizedHypothetical protein 4e-050.00132&radic S000003436ADE3YGR204WverifiedCytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase,involved in single carbon metabolism andrequired for biosynthesis of purines,thymidylate, methionine, and histidine 4e-050.00132&radic S000004835FSH2YMR222CverifiedSerine hydrolase that localizes to the cytoplasm; sequence issimilar to Fsh1p and Fsh3p 4e-050.00132 S000001327FIS1YIL065CverifiedMitochondrial outer membrane protein involved in membranefission, required for localization of Dnm1p andMdv1p during mitochondrial division 4e-050.00132 S000005196MRPL17YNL252CverifiedMitochondrial ribosomal protein of the large subunit 4e-050.00132 S000003264GSC2YGR032WverifiedCatalytic subunit of 1,3-beta-glucan synthase, involved information of the inner layer of the spore wall;activity positively regulated by Rho1p andnegatively by Smk1p; has similarity to analternate catalytic subunit, Fks1p (Gsc1p) 4e-050.00132 S000028627YER190C-BDubiousIdentified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 4e-050.00132 S000000377UMP1YBR173CverifiedShort-lived chaperone required for correct maturation of the20S proteasome; degraded by proteasome uponcompletion of its assembly; involved inubiquitin-mediated proteolysis; mutantdefective in degradation of short-livedproteins 4e-050.00132&radic S000001543FBA1YKL060CverifiedFructose 1,6-bisphosphate aldolase, required for glycolysis andgluconeogenesis; catalyzes conversion offructose 1,6 bisphosphate to glyceraldehyde-3-Pand dihydroxyacetone-P; locates tomitochondrial outer surface upon oxidativestress 4e-050.00132 S000005369MDM12YOL009CverifiedMitochondrial outer membrane protein, required for transmissionof mitochondria to daughter cells; exists in acomplex with Mmm1p and Mdm10p 4e-050.00132 S000003709RFA3YJL173CverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination 4e-050.00132&radic S000005496PFK27YOL136Cverified6-phosphofructo-2-kinase, catalyzes synthesis offructose-2,6-bisphosphate; inhibited byphosphoenolpyruvate and sn-glycerol3-phosphate, expression induced by glucose andsucrose, transcriptional regulation involvesprotein kinase A 4e-050.00132&radic S000004127YLR137WUncharacterizedHypothetical protein 4e-050.00132 S000000431MCX1YBR227CverifiedMitochondrial ATP-binding protein, possibly a mitochondrialchaperone with non-proteolytic function;similar to bacterial ClpX proteins 4e-050.00132 S000003297VHT1YGR065CverifiedHigh-affinity plasma membrane H+-biotin (vitamin H) symporter;mutation results in fatty acid auxotrophy; 12transmembrane domain containing majorfacilitator subfamily member; mRNA levelsnegatively regulated by iron deprivation andbiotin 4e-050.00132 S000000356SPP381YBR152WverifiedmRNA splicing factor, component of U4/U6.U5 tri-snRNP;interacts genetically and physically withPrp38p 4e-050.00132&radic&radic S000006325THI22YPR121WverifiedProtein with similarity to hydroxymethylpyrimidine phosphatekinases; member of a gene family with THI20 andTHI21; not required for thiamine biosynthesis 4e-050.00132 S000000834FIR1YER032WverifiedProtein involved in 3' mRNA processing, interacts with Ref2p;potential Cdc28p substrate 4e-050.00132 S000000684ABP1YCR088WverifiedActin-binding protein of the cortical actin cytoskeleton,important for activation of the Arp2/3 complexthat plays a key role actin in cytoskeletonorganization 4e-050.00132 S000006342MEP3YPR138CverifiedAmmonium permease of high capacity and low affinity; belongs toa ubiquitous family of cytoplasmic membraneproteins that transport only ammonium (NH4+);expression is under the nitrogen cataboliterepression regulation ammonia permease 4e-050.00132 S000003307PRP38YGR075CverifiedUnique component of the U4/U6.U5 tri-snRNP particle,dispensable for spliceosome assembly, butrequired for conformational changes which leadto catalytic activation of the spliceosome 4e-050.00132&radic S000005908FRE3YOR381WverifiedFerric reductase, reduces siderophore-bound iron prior touptake by transporters; expression induced bylow iron levels 4e-050.00132 S000002691GCN2YDR283CverifiedProtein kinase, phosphorylates the alpha-subunit of translationinitiation factor eIF2 (Sui2p) in response tostarvation; activated by uncharged tRNAs andthe Gcn1p-Gcn20p complex 4e-050.00132 S000002813MRP20YDR405WverifiedMitochondrial ribosomal protein of the large subunit 4e-050.00132 S000005121MRPL22YNL177CverifiedMitochondrial ribosomal protein of the large subunit 4e-050.00132 S000001466DAL1YIR027CverifiedAllantoinase, converts allantoin to allantoate in the firststep of allantoin degradation; expressionsensitive to nitrogen catabolite repression 4e-050.00132 S000001151CTM1YHR109WverifiedCytochrome c lysine methyltransferase, trimethylates residue 72of apo-cytochrome c (Cyc1p) in the cytosol; notrequired for normal respiratory growth 4e-050.00132 S000002407COS7YDL248WverifiedProtein of unknown function, member of the DUP380 subfamily ofconserved, often subtelomerically-encodedproteins; the authentic, non-tagged protein isdetected in highly purified mitochondria inhigh-throughput studies 4e-050.00132 S000005375IRC10YOL015WuncharacterizedHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 4e-050.00132 S000000160PRX1YBL064CverifiedMitochondrial peroxiredoxin (1-Cys Prx) with thioredoxinperoxidase activity, has a role in reduction ofhydroperoxides; induced during respiratorygrowth and under conditions of oxidative stress 4e-050.00132 S000003061SPC105YGL093WverifiedProtein required for accurate chromosome segregation, localizesto the nuclear side of the spindle pole body;forms a complex with Ydr532cp 4e-050.00132 S000004305SPH1YLR313CverifiedProtein involved in shmoo formation and bipolar bud siteselection; homologous to Spa2p, localizes tosites of polarized growth in a cell cycledependent- and Spa2p-dependent manner,interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p 4e-050.00132&radic&radic S000003300YGR068CUncharacterizedPutative protein of unknown function; YGR068C is not an essential gene. 4e-050.00132 S000002711RSC3YDR303CverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; essential gene required forregulation of ribosomal protein genes and thecell wall/stress response; highly similar toRsc30p 4e-050.00132&radic S000006402SGE1YPR198WverifiedMembrane-associated multidrug transporter, acts as an extrusionpermease, member of the drug-resistance proteinfamily within the major facilitator superfamily(MFS), partial multicopy suppressor of gal11mutations 4e-050.00132 S000000609YCR016WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; YCR016W is not an essential gene 4e-050.00132&radic S000003123CDC43YGL155WverifiedBeta subunit of geranylgeranyltransferase type I, catalyzesgeranylgeranylation to the cysteine residue inproteins containing a C-terminal CaaX sequenceending in Leu or Phe; has substrates importantfor morphogenesis 4e-050.00132&radic S000001917ATG18YFR021WverifiedPhosphatidylinositol 3,5-bisphosphate-binding protein of thevacuolar membrane, predicted to fold as aseven-bladed beta-propeller; required forrecycling of Atg9p through thepre-autophagosomal structure 4e-050.00132 S000007242YKL033W-AUncharacterizedPutative protein of unknown function; similar to uncharacterized proteins from other fungi 4e-050.00132 S000006345KAR3YPR141CverifiedMinus-end-directed microtubule motor that functions in mitosisand meiosis, localizes to the spindle pole bodyand localization is dependent on functionalCik1p, required for nuclear fusion duringmating; potential Cdc28p substrate 4e-050.00132&radic&radic&radic S000004410CDC73YLR418CverifiedConstituent of Paf1 complex with RNA polymerase II, Paf1p,Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinctfrom Srb-containing Pol II complexes; requiredfor expression of certain genes, modificationof some histones, and telomere maintenance 4e-050.00132&radic S000002452RPC11YDR045CverifiedRNA polymerase III subunit C11; mediates pol III RNA cleavageactivity and is important for termination oftranscription 4e-050.00132 S000003331TEL2YGR099WverifiedEssential DNA-binding protein specific to single-stranded yeasttelomeric DNA repeats, required for telomerelength regulation and telomere position effect 4e-050.00132 S000003810UTR1YJR049CverifiedATP-NADH kinase; phosphorylates both NAD and NADH; active as ahexamer; enhances the activity of ferricreductase (Fre1p) 4e-050.00132&radic S000003733UBP12YJL197WverifiedUbiquitin-specific protease present in the nucleus andcytoplasm that cleaves ubiquitin fromubiquitinated proteins 4e-050.00132&radic S000028837YIR018C-AUncharacterizedPutative protein of unknown function, identified by expression profiling and mass spectrometry 4e-050.00132 S000006102CTI6YPL181WverifiedProtein that relieves transcriptional repression by binding tothe Cyc8p-Tup1p corepressor and recruiting theSAGA complex to the repressed promoter;contains a PHD finger domain 4e-050.00132&radic S000002621UPC2YDR213WverifiedSterol regulatory element binding protein, inducestranscription of sterol transport andbiosynthetic genes; involved in the anaerobicinduction of DAN/TIR mannoproteins andseripauperins; binucleate zinc cluster protein;Ecm22p homolog 4e-050.00132&radic S000005532YOR006CUncharacterizedHypothetical protein 4e-050.00132&radic S000003044RPL7AYGL076CverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl7Bp and has similarity to E.coli L30 and rat L7 ribosomal proteins;contains a conserved C-terminal Nucleic acidBinding Domain (NDB2) 4e-050.00132&radic&radic S000002602MSS116YDR194CverifiedDEAD-box protein required for efficient splicing ofmitochondrial Group I and II introns; non-polarRNA helicase that also facilities strandannealing 4e-050.00132 S000002503GIS1YDR096WverifiedTranscriptional factor, involved in the expression of genesduring nutrient limitation; also involved inthe negative regulation of DPP1 and PHR1 4e-050.00132&radic S000002349UFD2YDL190CverifiedUbiquitin chain assembly factor (E4) that cooperates with aubiquitin-activating enzyme (E1), aubiquitin-conjugating enzyme (E2), and aubiquitin protein ligase (E3) to conjugateubiquitin to substrates; also functions as an 4e-050.00132&radic&radic S000005414YOL053WUncharacterizedPutative protein of unknown function; YOL053W is not an essential gene 4e-050.00132&radic S000001810FLO10YKR102WverifiedLectin-like protein with similarity to Flo1p, thought to beinvolved in flocculation 4e-050.00132 S000004829SKY1YMR216CverifiedSR protein kinase (SRPK) involved in regulating proteinsinvolved in mRNA metabolism and cationhomeostasis; similar to human SRPK1 4e-050.00132&radic&radic S000028529YBL008W-AUncharacterizedPutative protein of unknown function; identified by fungal homology and RT-PCR 4e-050.00132 S000000180CDC27YBL084CverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 4e-050.00132&radic S000005232CAF40YNL288WverifiedEvolutionarily conserved subunit of the CCR4-NOT complexinvolved in controlling mRNA initiation,elongation and degradation; binds Cdc39p 4e-050.00132 S000000758MCM3YEL032WverifiedProtein involved in DNA replication; component of the Mcm2-7hexameric complex that binds chromatin as apart of the pre-replicative complex 4e-050.00132 S000000815PRP22YER013WverifiedDEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase,associates with lariat intermediates before thesecond catalytic step of splicing; mediatesATP-dependent mRNA release from the spliceosomeand unwinds RNA duplexes 4e-050.00132&radic S000003066USE1YGL098WverifiedEssential SNARE protein localized to the ER, involved inretrograde traffic from the Golgi to the ER;forms a complex with the SNAREs Sec22p, Sec20pand Ufe1p 4e-050.00132 S000003683YJL147CUncharacterizedMitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene 4e-050.00132 S000002103PMP2YEL017C-AverifiedProteolipid associated with plasma membrane H(+)-ATPase(Pma1p); regulates plasma membrane H(+)-ATPaseactivity; nearly identical to PMP1 4e-050.00132 S000000019CCR4YAL021CverifiedComponent of the CCR4-NOT transcriptional complex, which isinvolved in regulation of gene expression;component of the major cytoplasmic deadenylase,which is involved in mRNA poly(A) tailshortening 4e-050.00132 S000004511GSF2YML048WverifiedER localized integral membrane protein that may promotesecretion of certain hexose transporters,including Gal2p; involved in glucose-dependentrepression 4e-050.00132 S000001168YHR126CUncharacterizedHypothetical protein 4e-050.00132 S000001651KKQ8YKL168CverifiedPutative serine/threonine protein kinase with unknown cellularrole 4e-050.00132 S000004521CMP2YML057WverifiedCalcineurin A; one isoform (the other is CNA1) of the catalyticsubunit of calcineurin, aCa++/calmodulin-regulated protein phosphatasewhich regulates Crz1p (a stress-responsetranscription factor), the other calcineurinsubunit is CNB1 4e-050.00132 S000003840YJR079WUncharacterizedPutative protein of unknown function; mutation results in impaired mitochondrial respiration 4e-050.00132 S000002230YET3YDL072CverifiedProtein of unknown function; YET3 null mutant decreases thelevel of secreted invertase; homolog of humanBAP31 protein 4e-050.00132 S000000647YCR051WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene 4e-050.00132&radic S000005162MGS1YNL218WverifiedProtein with DNA-dependent ATPase and ssDNA annealingactivities involved in maintenance of genome;interacts functionally with DNA polymerasedelta; homolog of human Werner helicaseinteracting protein (WHIP) 4e-050.00132&radic S000003025YGL057CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria; null mutant exhibits a growth defect on a non-fermentable (respiratory) carbon source; YGL057C is not an essential gene 4e-050.00132 S000004605YMR003WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria; YMR003W is not an essential gene 4e-050.00132 S000001717FOX2YKR009CverifiedMultifunctional enzyme of the peroxisomal fatty acidbeta-oxidation pathway; has 3-hydroxyacyl-CoAdehydrogenase and enoyl-CoA hydrataseactivities 4e-050.00132 S000004806MRPL24YMR193WverifiedMitochondrial ribosomal protein of the large subunit 4e-050.00132 S000005124RHO5YNL180CverifiedNon-essential small GTPase of the Rho/Rac subfamily of Ras-likeproteins, likely involved in protein kinase C(Pkc1p)-dependent signal transduction pathwaythat controls cell integrity 4e-050.00132&radic S000005651CAT5YOR125CverifiedMitochondrial inner membrane protein directly involved inubiquinone biosynthesis, essential for severalother metabolic pathways including respirationand gluconeogenic gene activation 4e-050.00132&radic&radic S000005296PHO91YNR013CverifiedLow-affinity phosphate transporter; deletion of pho84, pho87,pho89, pho90, and pho91 causes syntheticlethality; transcription independent of Pi andPho4p activity; overexpression results invigorous growth 4e-050.00132 S000006193YPL272CUncharacterizedHypothetical protein 4e-050.00132 S000004915ADE4YMR300CverifiedPhosphoribosylpyrophosphate amidotransferase (PRPPAT;amidophosphoribosyltransferase), catalyzesfirst step of the 'de novo' purine nucleotidebiosynthetic pathway 4e-050.00132 S000003059NBP35YGL091CverifiedEssential P-loop NTPase that functions in nuclear and cytosoliciron-sulfur (FeS) protein assembly; has ahighly conserved N-terminus 4e-050.00132&radic&radic S000006200YPL279CUncharacterizedHypothetical protein 4e-050.00132 S000004868GFD1YMR255WverifiedCoiled-coiled protein of unknown function, identified as ahigh-copy suppressor of a dbp5 mutation 4e-050.00132&radic S000003524MAL12YGR292WverifiedMaltase (alpha-D-glucosidase), inducible protein involved inmaltose catabolism; encoded in the MAL1 complexlocus 4e-050.00132&radic S000003428FYV8YGR196CverifiedProtein of unknown function, required for survival uponexposure to K1 killer toxin 4e-050.00132 S000001243RPN10YHR200WverifiedNon-ATPase base subunit of the 19S regulatory particle (RP) ofthe 26S proteasome; N-terminus plays a role inmaintaining the structural integrity of the RP;binds selectively to polyubiquitin chains;homolog of the mammalian S5a protein 4e-050.00132&radic S000000549MGR1YCL044CverifiedSubunit, with Yme1p, of the mitochondrial inner membrane i-AAAprotease complex, which is responsible fordegradation of unfolded or misfoldedmitochondrial gene products; required forgrowth of cells lacking the mitochondrialgenome 4e-050.00132 S000004277YLR287CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene 4e-050.00132 S000004585NAB6YML117WuncharacterizedPutative RNA-binding protein, based on computational analysisof large-scale protein-protein interaction data 4e-050.00132&radic S000028653YHR214C-DUncharacterizedIdentified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 4e-050.00132 S000004556RPM2YML091CverifiedProtein component of mitochondrial RNase P, along with themitochondrially-encoded RNA subunit RPM1; RnaseP removes 5' extensions from tRNA precursors;Rpm2p is also involved in maturation of RPM1and in translation of mitochondrial mRNAs 4e-050.00132 S000002818STE14YDR410CverifiedFarnesyl cysteine-carboxyl methyltransferase, mediates thecarboxyl methylation step during C-terminalCAAX motif processing of a-factor and RASproteins in the endoplasmic reticulum,localizes to the ER membrane 4e-050.00132 S000001012OPI1YHL020CverifiedTranscriptional regulator of a variety of genes;phosphorylation by protein kinase A stimulatesOpi1p function in negative regulation ofphospholipid biosynthetic genes; involved intelomere maintenance 4e-050.00132 S000028712YOR161C-CUncharacterizedIdentified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 4e-050.00132 S000005794YOR268CUncharacterizedPutative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene 4e-050.00132 S000005505CTR9YOL145CverifiedComponent of the Paf1p complex, which is a large complex thatbinds to and modulates the activity of RNApolymerase II and is required for expression ofa subset of genes, including cyclin genes;contains TPR repeats 4e-050.00132&radic&radic S000000242CHS2YBR038WverifiedChitin synthase II, requires activation from zymogenic form inorder to catalyze the transfer ofN-acetylglucosamine (GlcNAc) to chitin;required for the synthesis of chitin in theprimary septum during cytokinesis 4e-050.00132 S000000972ADK2YER170WverifiedMitochondrial adenylate kinase, catalyzes the reversiblesynthesis of GTP and AMP from GDP and ADP; mayserve as a back-up for synthesizing GTP or ADPdepending on metabolic conditions; 3' sequenceof ADK2 varies with strain background 4e-050.00132 S000007595DAD3YBR233W-AverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; is transferred to thekinetochore prior to mitosis 4e-050.00132 S000001445PAN1YIR006CverifiedPart of actin cytoskeleton-regulatory complexPan1p-Sla1p-End3p, associates with actinpatches on the cell cortex; promotesprotein-protein interactions essential forendocytosis; previously thought to be a subunitof poly(A) ribonuclease 4e-050.00132 S000005734PTP2YOR208WverifiedPhosphotyrosine-specific protein phosphatase involved in theinactivation of mitogen-activated proteinkinase (MAPK) during osmolarity sensing;dephosporylates Hog1p MAPK and regulates itslocalization; localized to the nucleus 4e-050.00132&radic S000003543CTK2YJL006CverifiedBeta subunit of C-terminal domain kinase I (CTDK-I), whichphosphorylates the C-terminal repeated domainof the RNA polymerase II large subunit (Rpo21p)to affect both transcription and pre-mRNA 3'end processing; has similarity to cyclins 4e-050.00132&radic S000001444IST3YIR005WverifiedComponent of the U2 snRNP, required for the first catalyticstep of splicing and for spliceosomal assembly;interacts with Rds3p and is required forMer1p-activated splicing 4e-050.00132&radic S000004727ADE17YMR120CverifiedEnzyme of 'de novo' purine biosynthesis containing both5-aminoimidazole-4-carboxamide ribonucleotidetransformylase and inosine monophosphatecyclohydrolase activities, isozyme of Ade16p;ade16 ade17 mutants require adenine andhistidine 4e-050.00132 S000000210UGA2YBR006WverifiedSuccinate semialdehyde dehydrogenase involved in theutilization of gamma-aminobutyrate (GABA) as anitrogen source; part of the 4-aminobutyrateand glutamate degradation pathways; localizedto the cytoplasm 4e-050.00132 S000000058GDH3YAL062WverifiedNADP(+)-dependent glutamate dehydrogenase, synthesizesglutamate from ammonia and alpha-ketoglutarate;rate of alpha-ketoglutarate utilization differsfrom Gdh1p; expression regulated by nitrogenand carbon sources 4e-050.00132&radic&radic S000000323MUD1YBR119WverifiedU1 snRNP A protein, homolog of human U1-A; involved in nuclearmRNA splicing 4e-050.00132&radic&radic&radic S000001591SLD2YKL108WverifiedProtein required for DNA replication, phosphorylated in S phaseby S-phase cyclin-dependent kinases (Cdks),phosphorylation is essential for DNAreplication and for complex formation withDpb11p; potential Cdc28p substrate 4e-050.00132&radic S000001553YKL070WUncharacterizedPutative protein of unknown function; detectable in highly purified mitochondria 4e-050.00132&radic S000006233APL4YPR029CverifiedGamma-adaptin, large subunit of the clathrin-associated protein(AP-1) complex; binds clathrin; involved invesicle mediated transport 4e-050.00132 S000002793EFT2YDR385WverifiedElongation factor 2 (EF-2), also encoded by EFT1; catalyzesribosomal translocation during proteinsynthesis; contains diphthamide, the uniqueposttranslationally modified histidine residuespecifically ADP-ribosylated by diphtheriatoxin 4e-050.00132 S000004304MRPL15YLR312W-AverifiedMitochondrial ribosomal protein of the large subunit 4e-050.00132 S000028632YGL007C-AUncharacterizedIdentified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 4e-050.00132 S000000022LTE1YAL024CverifiedPutative GDP/GTP exchange factor required for mitotic exit atlow temperatures; acts as a guanine nucleotideexchange factor (GEF) for Tem1p, which is a keyregulator of mitotic exit; physicallyassociates with Ras2p-GTP 4e-050.00132&radic S000001905GCN20YFR009WverifiedPositive regulator of the Gcn2p kinase activity, forms acomplex with Gcn1p; proposed to stimulate Gcn2pactivation by an uncharged tRNA 4e-050.00132 S000006344TAZ1YPR140WverifiedLyso-phosphatidylcholine acyltransferase, required for normalphospholipid content of mitochondrialmembranes; may remodel acyl groups ofcardiolipin in the inner membrane; similar tohuman tafazzin, which is implicated in Barthsyndrome 4e-050.00132 S000006162CIN2YPL241CverifiedTubulin folding factor C (putative) involved in beta-tubulin(Tub2p) folding; isolated as mutant withincreased chromosome loss and sensitivity tobenomyl 4e-050.00132 S000002844PPZ2YDR436WverifiedSerine/threonine protein phosphatase Z, isoform of Ppz1p;involved in regulation of potassium transport,which affects osmotic stability, cell cycleprogression, and halotolerance 4e-050.00132 S000005467YOL107WUncharacterizedHypothetical protein 4e-050.00132 S000002134FUN19YAL034CverifiedNon-essential protein of unknown function 4e-050.00132 S000000302MMS4YBR098WverifiedSubunit of the structure-specific Mms4p-Mus81p endonucleasethat cleaves branched DNA; involved inrecombination and DNA repair 4e-050.00132&radic S000002647YDR239CUncharacterizedHypothetical protein 4e-050.00132 S000001458MUC1YIR019CverifiedGPI-anchored cell surface glycoprotein required for diploidpseudohyphal formation and haploid invasivegrowth, transcriptionally regulated by the MAPKpathway (via Ste12p and Tec1p) and the cAMPpathway (via Flo8p) 4e-050.00132 S000005814MPD1YOR288CverifiedMember of the protein disulfide isomerase (PDI) family;interacts with and inhibits the chaperoneactivity of Cne1p; MPD1 overexpression in apdi1 null mutant suppresses defects in Pdi1pfunctions such as carboxypeptidase Y maturation 4e-050.00132 S000002895RIB3YDR487Cverified3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase),required for riboflavin biosynthesis fromribulose-5-phosphate, also has an unrelatedfunction in mitochondrial respiration 4e-050.00132&radic S000004206CPR6YLR216CverifiedPeptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzesthe cis-trans isomerization of peptide bondsN-terminal to proline residues; binds to Hsp82pand contributes to chaperone activity 4e-050.00132 S000002484SED1YDR077WverifiedMajor stress-induced structural GPI-cell wall glycoprotein instationary-phase cells, associates withtranslating ribosomes, possible role inmitochondrial genome maintenance; ORF containstwo distinct variable minisatellites 4e-050.00132 S000004802SGS1YMR190CverifiedNucleolar DNA helicase of the RecQ family involved inmaintenance of genome integrity, regulateschromosome synapsis and meiotic crossing over;has similarity to human BLM and WRN helicasesimplicated in Bloom and Werner syndromes 4e-050.0013&radic S000004848RNA1YMR235CverifiedGTPase activating protein (GAP) for Gsp1p, involved in nucleartransport 4e-050.0013 S000006320YPR116WUncharacterizedHypothetical protein 4e-050.0013 S000000575YCL073CUncharacterizedProtein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YKR106W 4e-050.0013&radic S000003979YLL056CUncharacterizedPutative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene 4e-050.0013 S000003849BIR1YJR089WverifiedEssential chromosomal passenger protein involved incoordinating cell cycle events for properchromosome segregation; C-terminal region bindsSli15p, and the middle region, uponphosphorylation, localizes Cbf2p to the spindleat anaphase 4e-050.0013&radic S000000126PET9YBL030CverifiedMajor ADP/ATP carrier of the mitochondrial inner membrane,exchanges cytosolic ADP for mitochondriallysynthesized ATP; required for viability in manycommon lab strains carrying a mutation in thepolymorphic SAL1 gene 4e-050.0013 S000001735BCH2YKR027WverifiedMember of the Chs5p-Arf1p-binding proteins (ChAPs), a group of4 related, interacting proteins (Bch1p, Fmp50p,Bud7p, Chs6p) that mediate export of specificcargo proteins, including chitin synthaseChs3p, from the Golgi to plasma membrane 4e-050.0013 S000002630YDR222WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 4e-050.0013 S000000076YAR028WUncharacterizedPutative integral membrane protein, member of DUP240 gene family 4e-050.0013 S000000344IRA1YBR140CverifiedGTPase-activating protein that negatively regulates RAS byconverting it from the GTP- to the GDP-boundinactive form, required for reducing cAMPlevels under nutrient limiting conditions,mediates membrane association of adenylatecyclase 4e-050.0013 S000002451HEM13YDR044WverifiedCoproporphyrinogen III oxidase, an oxygen requiring enzyme thatcatalyzes the sixth step in the hemebiosynthetic pathway; localizes to themitochondrial inner membrane; transcription isrepressed by oxygen and heme (via Rox1p andHap1p) 4e-050.0013&radic S000001733RPC37YKR025WverifiedRNA polymerase III subunit C37 4e-050.0013&radic S000003590TIM54YJL054WverifiedComponent of the mitochondrial Tim54p-Tim22p complex involvedin insertion of polytopic proteins into theinner membrane 4e-050.0013 S000004762NUP53YMR153WverifiedSubunit of the nuclear pore complex (NPC), interacts withkaryopherin Kap121p or with Nup170p viaoverlapping regions of Nup53p, involved inactivation of the spindle checkpoint mediatedby the Mad1p-Mad2p complex 4e-050.0013 S000000892TRP2YER090WverifiedAnthranilate synthase, catalyzes the initial step of tryptophanbiosynthesis, forms multifunctionalhetero-oligomeric anthranilatesynthase:indole-3-glycerol phosphate synthaseenzyme complex with Trp3p 4e-050.0013 S000006008YDC1YPL087WverifiedAlkaline dihydroceramidase, involved in sphingolipidmetabolism; preferentially hydrolyzesdihydroceramide to a free fatty acid anddihydrosphingosine; has a minor reverseactivity 4e-050.0013 S000003449CCH1YGR217WverifiedVoltage-gated high-affinity calcium channel involved in calciuminflux in response to some environmentalstresses as well as exposure to matingpheromones; interacts and co-localizes withMid1p, suggesting Cch1p and Mid1p functiontogether 4e-050.0013 S000004498AMD1YML035CverifiedAMP deaminase, tetrameric enzyme that catalyzes the deaminationof AMP to form IMP and ammonia; may be involvedin regulation of intracellular adeninenucleotide pools 4e-050.0013 S000002947YDR539WUncharacterizedHypothetical protein 4e-050.0013 S000005096YNL152WUncharacterizedProtein required for cell viability 4e-050.0013 S000005420GPD2YOL059WverifiedNAD-dependent glycerol 3-phosphate dehydrogenase, homolog ofGpd1p, expression is controlled by anoxygen-independent signaling pathway requiredto regulate metabolism under anoxic conditions;located in cytosol and mitochondria 4e-050.0013&radic S000001501SWD2YKL018WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lys 4 and is involved intelomeric silencing; subunit of CPF (cleavageand polyadenylation factor), a complex involvedin RNAP II transcription termination 4e-050.0013 S000000218YBR014CUncharacterizedHypothetical protein 4e-050.0013 S000004481OST6YML019WverifiedSubunit of the oligosaccharyltransferase complex of the ERlumen, which catalyzes asparagine-linkedglycosylation of newly synthesized proteins;similar to and partially functionally redundantwith Ost3p 4e-050.0013 S000004592PHO84YML123CverifiedHigh-affinity inorganic phosphate (Pi) transporter andlow-affinity manganese transporter; regulatedby Pho4p and Spt7p; mutation confers resistanceto arsenate; exit from the ER during maturationrequires Pho86p 4e-050.0013 S000004105CFT2YLR115WverifiedSubunit of the mRNA cleavage and polyadenlylation factor (CPF);required for pre-mRNA cleavage, polyadenylationand poly(A) site recognition, 43% similaritywith the mammalian CPSF-100 protein. 4e-050.0013&radic S000006164SRP68YPL243WverifiedCore component of the signal recognition particle (SRP)ribonucleoprotein (RNP) complex that functionsin targeting nascent secretory proteins to theendoplasmic reticulum (ER) membrane 4e-050.0013 S000004233YLR243WUncharacterizedPutative protein of unknown function; YLR243W is an essential gene 4e-050.0013 S000002151YBL111CUncharacterizedHelicase-like protein encoded within the telomeric Y' element 4e-050.0013 S000006108MF(ALPHA)1YPL187WverifiedMating pheromone alpha-factor, made by alpha cells; interactswith mating type a cells to induce cell cyclearrest and other responses leading to mating;also encoded by MF(ALPHA)2, although MF(ALPHA)1produces most alpha-factor 4e-050.0013 S000005902GDH1YOR375CverifiedNADP(+)-dependent glutamate dehydrogenase, synthesizesglutamate from ammonia and alpha-ketoglutarate;rate of alpha-ketoglutarate utilization differsfrom Gdh3p; expression regulated by nitrogenand carbon sources 4e-050.0013&radic S000004744GAT2YMR136WverifiedProtein containing GATA family zinc finger motifs; similar toGln3p and Dal80p; expression repressed byleucine 4e-050.0013 S000000801YEL075CUncharacterizedHypothetical protein 4e-050.0013 S000005977YPL056CUncharacterizedHypothetical protein 4e-050.0013 S000002309RPC53YDL150WverifiedRNA polymerase III subunit C53 4e-050.0013&radic S000003962UBI4YLL039CverifiedUbiquitin, becomes conjugated to proteins, marking them forselective degradation via the ubiquitin-26Sproteasome system; essential for the cellularstress response 4e-050.0013&radic S000006021ATG21YPL100WverifiedPhosphatidylinositol 3,5-bisphosphate-binding protein requiredfor maturation of pro-aminopeptidase I,predicted to fold as a seven-bladedbeta-propeller; displays punctate cytoplasmiclocalization 4e-050.0013 S000004218ECM22YLR228CverifiedSterol regulatory element binding protein, regulatestranscription of the sterol biosynthetic genesERG2 and ERG3; member of the fungus-specificZn[2]-Cys[6] binuclear cluster family oftranscription factors; homologous to Upc2p 4e-050.0013&radic S000003225ADH4YGL256WverifiedAlcohol dehydrogenase type IV, dimeric enzyme demonstrated tobe zinc-dependent despite sequence similarityto iron-activated alcohol dehydrogenases;transcription is induced in response to zincdeficiency; alcohol dehydrogenase isoenzyme IV 4e-050.0013 S000000929LCP5YER127WverifiedEssential protein involved in maturation of 18S rRNA; depletionleads to inhibited pre-rRNA processing andreduced polysome levels; localizes primarily tothe nucleolus 4e-050.0013 S000001339YIL077CUncharacterizedHypothetical protein 4e-050.0013 S000000433ROT2YBR229CverifiedGlucosidase II catalytic subunit required for normal cell wallsynthesis; mutations in rot2 suppress tor2mutations, and are synthetically lethal withrot1 mutations 4e-050.0013 S000005111SKO1YNL167CverifiedBasic leucine zipper (bZIP) transcription factor of theATF/CREB family, forms a complex with Tup1p andSsn6p to both activate and represstranscription; cytosolic and nuclear proteininvolved in osmotic and oxidative stressresponses 4e-050.0013&radic S000000572HMLALPHA2YCL067CverifiedSilenced copy of ALPHA2 at HML; homeobox-domain protein thatassociates with Mcm1p in haploid cells torepress a-specific gene expression andinteracts with a1p in diploid cells to represshaploid-specific gene expression 4e-050.0013 S000003759PAU1YJL223CverifiedPart of 23-member seripauperin multigene family encoded mainlyin subtelomeric regions, active duringalcoholic fermentation, regulated byanaerobiosis, negatively regulated by oxygen,repressed by heme 4e-050.0013&radic S000005573STD1YOR047CverifiedProtein involved in control of glucose-regulated geneexpression; interacts with protein kinaseSnf1p, glucose sensors Snf3p and Rgt2p, andTATA-binding protein Spt15p; acts as aregulator of the transcription factor Rgt1p 4e-050.0013 S000005942ECM23YPL021WverifiedNon-essential protein of unconfirmed function; affects pre-rRNAprocessing, may act as a negative regulator ofthe transcription of genes involved inpseudohyphal growth; homologous to Srd1p 4e-050.0013 S000003934SOF1YLL011WverifiedEssential subunit of the U3 (box C+D) snRNP complex requiredfor 2' O-methylation of pre-RNA; has similarityto the beta subunit of trimeric G-proteins andthe splicing factor Prp4p 4e-050.0013 S000028518YCL058W-AUncharacterizedProtein of unknown function; identified by homology to Ashbya gossypii 4e-050.0013 S000005015LAT1YNL071WverifiedDihydrolipoamide acetyltransferase component (E2) of pyruvatedehydrogenase complex, which catalyzes theoxidative decarboxylation of pyruvate toacetyl-CoA 4e-050.0013 S000006434LSM3YLR438C-AverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 4e-050.0013&radic S000005424CRT10YOL063CverifiedProtein involved in transcriptional regulation of RNR2 andRNR3; expression of the gene is induced by DNAdamage and null mutations confer increasedresistance to hydroxyurea; N-terminal regionhas a leucine repeat and a WD40 repeat 4e-050.0013&radic S000001298CST6YIL036WverifiedBasic leucine zipper (bZIP) transcription factor of theATF/CREB family, activates transcription ofgenes involved in utilization of non-optimalcarbon sources; involved in telomeremaintenance 4e-050.0013&radic S000002819DFM1YDR411CuncharacterizedER localized derlin-like family member involved in ER stressand homeostasis; not involved in ERAD orsubstrate retrotranslocation; interacts withCDC48; contains four transmembrane domains andtwo SHP boxes 4e-050.0013 S000003639GSM1YJL103CuncharacterizedPutative zinc cluster protein of unknown function; proposed tobe involved in the regulation of energymetabolism, based on patterns of expression andsequence analysis 4e-050.0013 S000002398ADY3YDL239CverifiedProtein required for spore wall formation, thought to mediateassembly of a Don1p-containing structure at theleading edge of the prospore membrane viainteraction with spindle pole body components;potentially phosphorylated by Cdc28p 4e-050.0013 S000004004PPR1YLR014CverifiedZinc finger transcription factor containing a Zn(2)-Cys(6)binuclear cluster domain, positively regulatestranscription of genes involved in uracilbiosynthesis; activity may be modulated byinteraction with Tup1p 4e-050.0013 S000087203YCL048W-AUncharacterizedPutative protein of unknown function 4e-050.0013 S000005068NAF1YNL124WverifiedProtein required for the assembly of box H/ACA snoRNPs and forpre-rRNA processing, forms a complex with Shq1pand interacts with H/ACA snoRNP componentsNhp2p and Cbf5p; has similarity to Gar1p andother RNA-binding proteins 4e-050.0013&radic S000000688MSH3YCR092CverifiedMismatch repair protein, forms dimers with Msh2p that mediaterepair of insertion or deletion mutations andremoval of nonhomologous DNA ends, contains aPCNA (Pol30p) binding motif required for genomestability 4e-050.00128&radic S000006168YPL247CUncharacterizedHypothetical protein 4e-050.00128&radic S000000773YEL047CVerifiedFumurate ReDuctase Soluble 4e-050.00128&radic S000004244NDL1YLR254Cuncharacterizedhomolog of nuclear distribution factor NudE, NUDEL 4e-050.00128&radic S000004794RGM1YMR182CverifiedPutative transcriptional repressor with proline-rich zincfingers; overproduction impairs cell growth 4e-050.00128&radic S000004961PUB1YNL016WverifiedPoly(A)+ RNA-binding protein, abundant mRNP-component proteinthat binds mRNA and is required for stabilityof a number of mRNAs; not reported to associatewith polyribosomes 4e-050.00128 S000000459YBR255WUncharacterizedProtein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 4e-050.00128&radic S000002518ALT2YDR111CuncharacterizedPutative alanine transaminase (glutamic pyruvic transaminase) 4e-050.00128&radic&radic S000005135DUG3YNL191WuncharacterizedProtein involved in alternative pathway of glutathionedegradation 4e-050.00128 S000005363PFA4YOL003CverifiedPalmitoyltransferase with autoacylation activity, required forpalmitoylation of amino acid permeasescontaining a C-terminal Phe-Trp-Cys site;required for modification of Chs3p; member ofthe DHHC family of putativepalmitoyltransferases 4e-050.00128 S000004479PSP2YML017WverifiedAsn rich cytoplasmic protein that contains RGG motifs;high-copy suppressor of group IIintron-splicing defects of a mutation in MRS2and of a conditional mutation in POL1 (DNApolymerase alpha); possible role inmitochondrial mRNA splicing 4e-050.00128 S000007615YKL018C-AUncharacterizedPutative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 4e-050.00128 S000004862GAD1YMR250WverifiedGlutamate decarboxylase, converts glutamate intogamma-aminobutyric acid (GABA) during glutamatecatabolism; involved in response to oxidativestress 4e-050.00128 S000006002RPS9AYPL081WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps9Bp and has similarity to E.coli S4 and rat S9 ribosomal proteins 4e-050.00128 S000002129ERP1YAR002C-AverifiedProtein that forms a heterotrimeric complex with Erp2p, Emp24p,and Erv25p; member, along with Emp24p andErv25p, of the p24 family involved in ER toGolgi transport and localized to COPII-coatedvesicles 4e-050.00128 S000003298YGR066CUncharacterizedPutative protein of unknown function 4e-050.00128 S000002456YDR049WUncharacterizedZinc finger protein; putative transcription factor that may interact with proteins involved in histone acetylation or deacetylation; may be involved in altering acetylation on histone lysines 4e-050.00128 S000000728WBP1YEL002CverifiedBeta subunit of the oligosaccharyl transferase (OST)glycoprotein complex; required for N-linkedglycosylation of proteins in the endoplasmicreticulum 4e-050.00128 S000001038PAU13YHL046CuncharacterizedPutative protein of unknown function; not an essential gene 4e-050.00128 S000003319PDC6YGR087CverifiedMinor isoform of pyruvate decarboxylase, key enzyme inalcoholic fermentation, decarboxylates pyruvateto acetaldehyde, regulation is glucose- andethanol-dependent, involved in amino acidcatabolism 4e-050.00128 S000003138SPO74YGL170CverifiedComponent of the meiotic outer plaque of the spindle pole body,involved in modifying the meiotic outer plaquethat is required prior to prospore membraneformation 4e-050.00128 S000006378YPR174CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate 4e-050.00128 S000004308TAD3YLR316CverifiedSubunit of tRNA-specific adenosine-34 deaminase, forms aheterodimer with Tad2p that converts adenosineto inosine at the wobble position of severaltRNAs 4e-050.00128&radic S000000772GLY1YEL046CverifiedThreonine aldolase, catalyzes the cleavage of L-allo-threonineand L-threonine to glycine; involved in glycinebiosynthesis 4e-050.00128&radic S000002739GPI8YDR331WverifiedER membrane glycoprotein subunit of theglycosylphosphatidylinositol transamidasecomplex that adds glycosylphosphatidylinositol(GPI) anchors to newly synthesized proteins;human PIG-K protein is a functional homolog 4e-050.00128 S000002592ATC1YDR184CverifiedNuclear protein, possibly involved in regulation of cationstress responses and/or in the establishment ofbipolar budding pattern 4e-050.00128&radic S000003609JEM1YJL073WverifiedDnaJ-like chaperone required for nuclear membrane fusion duringmating, localizes to the ER membrane; exhibitsgenetic interactions with KAR2 4e-050.00128 S000003681SFH5YJL145WverifiedPutative phosphatidylinositol transfer protein (PITP), exhibitsphosphatidylinositol- but notphosphatidylcholine-transfer activity, mainlylocalized to cytosol and microsomes, similar toSec14p; may be PITP regulator rather thanactual PITP 4e-050.00128&radic S000001156BZZ1YHR114WverifiedSH3 domain protein implicated in the regulation of actinpolymerization, able to recruit actinpolymerization machinery through its SH3domains, colocalizes with cortical actinpatches and Las17p, interacts with type Imyosins 4e-050.00128 S000000790AVT2YEL064CverifiedPutative transporter, member of a family of seven S. cerevisiaegenes (AVT1-7) related to vesicularGABA-glycine transporters 4e-050.00128&radic S000007592PAU9YBL108C-AuncharacterizedHypothetical protein identified by homology. See FEBS Letters[2000] 487:31-36. 4e-050.00128 S000005110BNI5YNL166CverifiedProtein involved in organization of septins at the mother-budneck, may interact directly with the Cdc11pseptin, localizes to bud neck in aseptin-dependent manner 4e-050.00128 S000006178YPL257WUncharacterizedHypothetical protein 4e-050.00128 S000002158YSY6YBR162W-AverifiedProtein whose expression suppresses a secretory pathwaymutation in E. coli; has similarity to themammalian RAMP4 protein involved in secretion 4e-050.00128 S000001056SPO13YHR014WverifiedMeiosis-specific protein, involved in maintaining sisterchromatid cohesion during meiosis I as well aspromoting proper attachment of kinetochores tothe spindle during meiosis I and meiosis II 4e-050.00128 S000001649TPK3YKL166CverifiedSubunit of cAMP-dependent protein kinase, which contains Tpk1p,Tpk2p, Tpk3p, and regulatory subunit Bcy1p;promotes growth in response to nutrients;mediates induction of apoptosis due toactin-mediated hyperactivation of Ras signaling 4e-050.00128&radic S000002817SIZ1YDR409WverifiedSUMO ligase that promotes the attachment of sumo (Smt3p; smallubiquitin-related modifier) to proteins; bindsUbc9p and may bind septins; specificallyrequired for sumoylation of septins in vivo;localized to the septin ring 4e-050.00128&radic S000001744CAF4YKR036CverifiedWD40 repeat-containing protein associated with the CCR4-NOTcomplex, interacts in a Ccr4p-dependent mannerwith Ssn2p; also interacts with Fis1p, Mdv1pand Dnm1p and plays a role in mitochondrialfission 4e-050.00128 S000004772DNF3YMR162CverifiedAminophospholipid translocase (flippase) that maintainsmembrane lipid asymmetry in post-Golgisecretory vessicles; localizes to thetrans-Golgi network; likely involved in proteintransport; type 4 P-type ATPase 4e-050.00128 S000002435REG1YDR028CverifiedRegulatory subunit of type 1 protein phosphatase Glc7p,involved in negative regulation ofglucose-repressible genes 4e-050.00128 S000000178ALG3YBL082CverifiedDolichol-P-Man dependent alpha(1-3) mannosyltransferase,involved in the synthesis of dolichol-linkedoligosaccharide donor for N-linkedglycosylation of proteins 4e-050.00128 S000004500CGI121YML036WverifiedProtein involved in telomere uncapping and elongation ascomponent of the KEOPS protein complex withBud32p, Kae1p, Pcc1p, and Gon7p; also shown tobe a component of the EKC protein complex;homolog of human CGI-121 4e-050.00128 S000003435YGR203WUncharacterizedPutative protein with sequence similarity to protein tyrosine phosphatases of the CDC25-like phosphatase family; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 4e-050.00128&radic S000007239YER138W-AUncharacterizedPutative protein of unknown function 4e-050.00128 S000000482DPB3YBR278WverifiedThird-largest subunit of DNA polymerase II (DNA polymeraseepsilon), required to maintain fidelity ofchromosomal replication and also forinheritance of telomeric silencing; mRNAabundance peaks at the G1/S boundary of thecell cycle 4e-050.00128&radic S000002403THI13YDL244WverifiedProtein involved in synthesis of the thiamine precursorhydroxymethylpyrimidine (HMP); member of asubtelomeric gene family including THI5, THI11,THI12, and THI13 4e-050.00128 S000004981NCE103YNL036WverifiedCarbonic anhydrase; poorly transcribed under aerobic conditionsand at an undetectable level under anaerobicconditions; involved in non-classical proteinexport pathway 4e-050.00128&radic S000001059YSC83YHR017WverifiedNon-essential mitochondrial protein of unknown function; mRNAinduced during meiosis, peaking between mid tolate prophase of meiosis I; similar to S.douglasii YSD83 4e-050.00128 S000001484MET14YKL001CverifiedAdenylylsulfate kinase, required for sulfate assimilation andinvolved in methionine metabolism 4e-050.00128 S000004315CWC24YLR323CverifiedEssential protein, component of a complex containing Cef1p; hassimilarity to S. pombe Cwf24p 4e-050.00128&radic&radic S000000487SSH1YBR283CverifiedSubunit of the Ssh1 translocon complex; Sec61p homolog involvedin co-translational pathway of proteintranslocation; not essential 4e-050.00128 S000001397VHS2YIL135CverifiedCytoplasmic protein of unknown function; identified as ahigh-copy suppressor of the synthetic lethalityof a sis2 sit4 double mutant, suggesting a rolein G1/S phase progression; similar to Mlf3p 4e-050.00128 S000001206SOL3YHR163Wverified6-phosphogluconolactonase, catalyzes the second step of thepentose phosphate pathway; weak multicopysuppressor of los1-1 mutation; homologous toSol2p and Sol1p 4e-050.00128&radic S000002445ENA5YDR038CverifiedProtein with similarity to P-type ATPase sodium pumps 4e-050.00128 S000007266AI5_BETAQ0075uncharacterizedProtein of unknown function, encoded within an intron of themitochondrial COX1 gene; translationalinitiation codon is predicted to be ATA ratherthan ATG 4e-050.00128 S000005472MSB4YOL112WverifiedGTPase-activating protein of the Ras superfamily that actsprimarily on Sec4p, localizes to the bud siteand bud tip, has similarity to Msb3p; msb3 msb4double mutation causes defects in secretion andactin organization 4e-050.00128 S000002894VPS60YDR486CverifiedCytoplasmic and vacuolar membrane protein involved in lateendosome to vacuole transport; required fornormal filament maturation during pseudohyphalgrowth; may function in targeting specificcargo proteins for degradation 4e-050.00128 S000000623FEN2YCR028CverifiedPlasma membrane H+-pantothenate symporter; confers sensitivityto the antifungal agent fenpropimorph 4e-050.00128 S000000142PSY4YBL046WverifiedPutative regulatory subunit of an evolutionarily conservedprotein phosphatase complex containing thecatalytic subunit Pph3p and a third subunitPsy2p; required for cisplatin resistance;GFP-fusion protein localizes to the nucleus 4e-050.00128&radic S000004097REX3YLR107WverifiedRNA exonuclease; required for maturation of the RNA componentof RNase MRP; functions redundantly with Rnh70pand Rex2p in processing of U5 snRNA and RNase PRNA; member of RNase D family of exonucleases 4e-050.00128&radic S000005564HIR2YOR038CverifiedNon-essential transcriptional corepressor involved in the cellcycle-regulated transcription of histone H2A,H2B, H3, and H4 genes; recruits Swi-Snfcomplexes to histone gene promoters; promotesheterochromatic gene silencing with Asf1p 4e-050.00128&radic S000001663RPL17AYKL180WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl17Bp and has similarity to E.coli L22 and rat L17 ribosomal proteins;copurifies with the Dam1 complex (aka DASHcomplex) 4e-050.00128 S000004731YMR124WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene 4e-050.00128 S000004003GAT3YLR013WverifiedProtein containing GATA family zinc finger motifs 4e-050.00128 S000003917THI11YJR156CverifiedProtein involved in synthesis of the thiamine precursorhydroxymethylpyrimidine (HMP); member of asubtelomeric gene family including THI5, THI11,THI12, and THI13 4e-050.00128 S000001478YPS6YIR039CverifiedPutative GPI-anchored aspartic protease 4e-050.00128 S000003741YJL206CUncharacterizedPutative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment 4e-050.00128 S000006432EST3YIL009C-AverifiedComponent of the telomerase holoenzyme, involved in telomerereplication 4e-050.00128 S000003677YAK1YJL141CverifiedSerine-threonine protein kinase that is part of aglucose-sensing system involved in growthcontrol in response to glucose availability;translocates from the cytoplasm to the nucleusand phosphorylates Pop2p in response to aglucose signal 4e-050.00128 S000002381FMP45YDL222CverifiedIntegral membrane protein localized to mitochondria (untaggedprotein) and eisosomes, immobile patches at thecortex associated with endocytosis; sporulationand sphingolipid content are altered inmutants; has homologs SUR7 and YNL194C 4e-050.00128 S000005370RCL1YOL010WverifiedRNA terminal phosphate cyclase-like protein involved in rRNAprocessing at sites A0, A1, and A2; does notpossess detectable RNA cyclase activity 4e-050.00128&radic S000003362YGR130CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7) 4e-050.00128 S000004856ZRC1YMR243CverifiedVacuolar membrane zinc transporter, transports zinc from thecytosol into the vacuole for storage; also hasa role in resistance to zinc shock resultingfrom a sudden influx of zinc into the cytoplasm 4e-050.00128 S000002454HEM12YDR047WverifiedUroporphyrinogen decarboxylase, catalyzes the fifth step in theheme biosynthetic pathway; localizes to boththe cytoplasm and nucleus; activity inhibitedby Cu2+, Zn2+, Fe2+, Fe3+ andsulfhydryl-specific reagents 4e-050.00128&radic S000002239RPP1AYDL081CverifiedRibosomal protein P1 alpha, a component of the ribosomal stalk,which is involved in the interaction betweentranslational elongation factors and theribosome; accumulation of P1 in the cytoplasmis regulated by phosphorylation and interactionwith the P2 stalk component 4e-050.00128 S000005067NMA111YNL123WverifiedProtein of unknown function which may contribute to lipidhomeostasis and/or apoptosis; sequencesimilarity to the mammalian Omi/HtrA2 family ofserine proteases 4e-050.00128&radic S000005762DFR1YOR236WverifiedDihydrofolate reductase, part of the dTTP biosynthetic pathway,involved in folate metabolism, possiblyrequired for mitochondrial function 4e-050.00128 S000006439HTL1YCR020W-BverifiedSubunit of the RSC chromatin remodeling complex, a multisubunitcomplex that functions in transcriptionalregulation, chromosome stability andestablishing sister chromatid cohesion;involved in telomere maintenance 4e-050.00128&radic S000004379REH1YLR387CverifiedProtein of unknown function, similar to Rei1p but not involvedin bud growth; contains dispersed C2H2 zincfinger domains 4e-050.00128 S000006104YPL183CUncharacterizedHypothetical protein 4e-050.00128 S000005275AAD14YNL331CverifiedPutative aryl-alcohol dehydrogenase with similarity to P.chrysosporium aryl-alcohol dehydrogenase;mutational analysis has not yet revealed aphysiological role 4e-050.00128 S000001106SSZ1YHR064CverifiedHsp70 protein that interacts with Zuo1p (a DnaJ homolog) toform a ribosome-associated complex that bindsthe ribosome via the Zuo1p subunit; alsoinvolved in pleiotropic drug resistance viasequential activation of PDR1 and PDR5; bindsATP 4e-050.00128 S000004342ORM2YLR350WverifiedEvolutionarily conserved protein with similarity to Orm1p,required for resistance to agents that inducethe unfolded protein response; human orthologis located in the endoplasmic reticulum 4e-050.00128 S000005602SKI7YOR076CverifiedAntiviral adaptor protein that mediates interactions via itsN-terminus between the exosome and Ski complex(Ski2p, Ski3p, Ski8p) which operate in the3'-to-5' mRNA-decay pathway; cytoplasmicprotein required for degrading nonstop mRNAs 4e-050.00128 S000005837NOP58YOR310CverifiedProtein involved in pre-rRNA processing, 18S rRNA synthesis,and snoRNA synthesis; component of the smallsubunit processome complex, which is requiredfor processing of pre-18S rRNA 4e-050.00128 S000005507PEX11YOL147CverifiedPeroxisomal membrane protein required for peroxisomeproliferation and medium-chain fatty acidoxidation, most abundant protein in theperoxisomal membrane, regulated by Adr1p andPip2p-Oaf1p, promoter contains ORE andUAS1-like elements 4e-050.00128&radic&radic S000002806UTP5YDR398WverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 4e-050.00128 S000005213BSC4YNL269WverifiedProtein of unknown function, ORF exhibits genomic organizationcompatible with a translationalreadthrough-dependent mode of expression;readthrough is increased upon depletion ofSup35p 4e-050.00128 S000004623MAC1YMR021CverifiedCopper-sensing transcription factor involved in regulation ofgenes required for high affinity coppertransport 4e-050.00128&radic S000002734YSP2YDR326CverifiedProtein involved in programmed cell death; mutant showsresistance to cell death induced by amiodaroneor intracellular acidification 4e-050.00128 S000003966FPS1YLL043WverifiedPlasma membrane glycerol channel, member of the major intrinsicprotein (MIP) family of channel proteins;involved in efflux of glycerol and in uptake ofthe trivalent metalloids arsenite andantimonite 4e-050.00128 S000003648MDV1YJL112WverifiedPeripheral protein of the cytosolic face of the mitochondrialouter membrane, required for mitochondrialfission; interacts with Fis1p and with thedynamin-related GTPase Dnm1p; contains WDrepeats 4e-050.00128 S000002704MHR1YDR296WverifiedProtein involved in homologous recombination in mitochondriaand in transcription regulation in nucleus;binds to activation domains of acidicactivators; required forrecombination-dependent mtDNA partitioning 4e-050.00128 S000001455YIR016WUncharacterizedPutative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR016W is a non-essential gene 4e-050.00128 S000005786GCD1YOR260WverifiedGamma subunit of the translation initiation factor eIF2B, theguanine-nucleotide exchange factor for eIF2;activity subsequently regulated byphosphorylated eIF2; first identified as anegative regulator of GCN4 expression 4e-050.00128 S000003812OSM1YJR051WverifiedFumarate reductase, catalyzes the reduction of fumarate tosuccinate, required for the reoxidation ofintracellular NADH under anaerobic conditions;mutations cause osmotic sensitivity 4e-050.00128 S000006007ELP3YPL086CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;exhibits histone acetyltransferase activitythat is directed to histones H3 and H4;disruption confers resistance to K. lactiszymotoxin 4e-050.00128 S000003749YJL213WUncharacterizedPutative protein of unknown function; periodically expressed during the yeast metabolic cycle; expression induced in respiratory incompetent petite cells; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p 4e-050.00128&radic&radic S000001086DOG1YHR044Cverified2-deoxyglucose-6-phosphate phosphatase, similar to Dog2p,member of a family of low molecular weightphosphatases; confers 2-deoxyglucose resistancewhen overexpressed, in vivo substrate has notyet been identified 4e-050.00128&radic S000004460YPT7YML001WverifiedGTPase; GTP-binding protein of the rab family; required forhomotypic fusion event in vacuole inheritance,for endosome-endosome fusion, similar tomammalian Rab7 4e-050.00128&radic S000006189PLC1YPL268WverifiedPhosphoinositide-specific phospholipase C, hydrolyzesphosphatidylinositol 4,5-biphosphate (PIP2) togenerate inositol 1,4,5-triphosphate (IP3) and1,2-diacylglycerol (DAG); involved inkinetochore function and pseudohyphaldifferentiation 4e-050.00128&radic S000000140YBL044WUncharacterizedHypothetical protein 4e-050.00128&radic S000004271YLR281CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene 4e-050.00128&radic S000002443EHD3YDR036CverifiedProtein of unconfirmed function, plays an indirect role inendocytic membrane trafficking, member of afamily of enoyl-CoA hydratase/isomerases; thenon-tagged protein is detected in highlypurified mitochondria in high-throughputstudies 4e-050.00128&radic&radic S000004378VAC14YLR386WverifiedProtein involved in regulated synthesis of PtdIns(3,5)P(2), incontrol of trafficking of some proteins to thevacuole lumen via the MVB, and in maintenanceof vacuole size and acidity; activator of Fab1p 4e-050.00128 S000001418UBP7YIL156WverifiedUbiquitin-specific protease that cleaves ubiquitin-proteinfusions 4e-050.00128 S000006131SRP72YPL210CverifiedCore component of the signal recognition particle (SRP)ribonucleoprotein (RNP) complex that functionsin targeting nascent secretory proteins to theendoplasmic reticulum (ER) membrane 4e-050.00128 S000003647CCT7YJL111WverifiedSubunit of the cytosolic chaperonin Cct ring complex, relatedto Tcp1p, required for the assembly of actinand tubulins in vivo 4e-050.00128 S000003099SNT2YGL131CverifiedDNA binding protein with similarity to the S. pombe Snt2protein 4e-050.00128&radic&radic S000004049REX2YLR059CverifiedRNA exonuclease, required for U4 snRNA maturation; functionsredundantly with Rnh70p in 5.8S rRNAmaturation, and with Rnh70p and Rex3p inprocessing of U5 snRNA and RNase P RNA; memberof RNase D family of exonucleases 4e-050.00128&radic S000002342YDL183CUncharacterizedPutative protein of unknown function; YBR063C is not an essential gene 4e-050.00128&radic S000001903YFR007WUncharacterizedPutative protein of unknown function with similarity to pantothenate kinases from other organisms; YFR007W is not an essential gene 4e-050.00128 S000001013FMP12YHL021CuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 4e-050.00128 S000005301YNR018WUncharacterizedHypothetical protein 4e-050.00128 S000004338YLR346CUncharacterizedPutative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene 4e-050.00128 S000005146SPS19YNL202WverifiedPeroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme offatty acid beta-oxidation; homodimeric enzymerequired for growth and sporulation onpetroselineate medium; expression inducedduring late sporulation and in the presence ofoleate 4e-050.00128 S000005731FMP38YOR205CuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 4e-050.00128&radic S000001937ERJ5YFR041CuncharacterizedType I membrane protein with a J domain is required to preservethe folding capacity of the endoplasmicreticulum; loss of the non-essential ERJ5 geneleads to a constitutively induced unfoldedprotein response 4e-050.00128&radic S000004786PAI3YMR174CverifiedCytoplasmic proteinase A inhibitor, dependent on Pbs2p andHog1p protein kinases for osmotic induction;intrinsically unstructured, N-terminal halfbecomes ordered in the active site ofproteinase A upon contact 4e-050.00128&radic S000004235CDD1YLR245CverifiedCytidine deaminase; catalyzes the modification of cytidine touridine in vitro but native RNA substrates havenot been identified, localizes to both thenucleus and cytoplasm 4e-050.00128&radic S000003461SMI1YGR229CverifiedProtein involved in the regulation of cell wall synthesis;proposed to be involved in coordinating cellcycle progression with cell wall integrity 4e-050.00128 S000006009YPL088WUncharacterizedPutative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance 4e-050.00128 S000005233PCL1YNL289WverifiedPho85 cyclin of the Pcl1,2-like subfamily, involved in entryinto the mitotic cell cycle and regulation ofmorphogenesis, localizes to sites of polarizedcell growth 4e-050.00128 S000001861RIM15YFL033CverifiedGlucose-repressible protein kinase involved in signaltransduction during cell proliferation inresponse to nutrients, specifically theestablishment of stationary phase; originallyidentified as a regulator of IME2 4e-050.00128 S000006151YPL230WUncharacterizedPutative protein of unknown function 4e-050.00128 S000001143BIG1YHR101CverifiedIntegral membrane protein of the endoplasmic reticulum,required for normal content of cell wallbeta-1,6-glucan 4e-050.00128 S000002608VPS64YDR200CverifiedCytoplasmic protein required for cytoplasm to vacuole targetingof proteins; forms a complex with Far3p, Far7p,Far10p, and Far11p that is involved inpheromone-induced cell cycle arrest; alsolocalized to the endoplasmic reticulum membrane 4e-050.00128 S000003349YGR117CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 4e-050.00128 S000000195ATP1YBL099WverifiedAlpha subunit of the F1 sector of mitochondrial F1F0 ATPsynthase, which is a large, evolutionarilyconserved enzyme complex required for ATPsynthesis 4e-050.00128 S000000635MATALPHA2YCR039CverifiedHomeobox-domain protein that, with Mcm1p, represses a-specificgenes in haploids; acts with A1p to represstranscription of haploid-specific genes indiploids; one of two genes encoded by theMATalpha mating type cassette 4e-050.00128 S000000499PCA1YBR295WverifiedCadmium transporting P-type ATPase; may also have a role incopper and iron homeostasis; S288C and mostother lab strains contain a G970R mutationwhich eliminates normal cadmium transportfunction 4e-050.00128 S000000988YER186CUncharacterizedHypothetical protein 4e-050.00128 S000005331YNR048WVerifiedProtein proposed to interact with phospholipid translocases, shares similarity to Cdc50p 4e-050.00128 S000003805VPS55YJR044CverifiedLate endosomal protein involved in late endosome to vacuoletrafficking; functional homolog of humanobesity receptor gene-related protein (OB-RGRP) 4e-050.00128 S000005670ELG1YOR144CverifiedProtein required for S phase progression and telomerehomeostasis, forms an alternative replicationfactor C complex important for DNA replicationand genome integrity; involved in homologousrecombination-mediated DNA repair 4e-050.00128&radic S000001691CBT1YKL208WverifiedProtein involved in 5' end processing of mitochondrial COB,15S_rRNA, and RPM1 transcripts; may also have arole in 3' end processing of the COB pre-mRNA;displays genetic interaction with cellcycle-regulated kinase Dbf2p 4e-050.00128 S000006078TGS1YPL157WverifiedTrimethyl guanosine synthase, conserved nucleolar methyltransferase responsible for conversion of them(7)G cap structure of snRNAs and snoRNAs tom(2,2,7)G; also required for ribosome synthesisand nucleolar morphology 4e-050.00128 S000001626LTV1YKL143WverifiedComponent of the GSE complex, which is required for propersorting of amino acid permease Gap1p; requiredfor ribosomal small subunit export fromnucleus; required for growth at low temperature 4e-050.00128 S000003511SCW4YGR279CverifiedCell wall protein with similarity to glucanases; scw4 scw10double mutants exhibit defects in mating 4e-050.00128 S000004576YML108WUncharacterizedPutative protein of unknown function whose structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene 4e-050.00128&radic S000003929MMM1YLL006WverifiedMitochondrial outer membrane protein required for normalmitochondrial morphology and mtDNA stability;involved in tethering mitochondria to the actincytoskeleton and in anchoring mtDNA nucleoids 4e-050.00128 S000001852YFL042CUncharacterizedPutative protein of unknown function; YFL042C is not an essential gene 4e-050.00128 S000000312YBR108WUncharacterizedProtein interacting with Rsv167p 4e-050.00128 S000001308MET30YIL046WverifiedF-box protein containing five copies of the WD40 motif,controls cell cycle function, sulfurmetabolism, and methionine biosynthesis as partof the ubiquitin ligase complex; interacts withand regulates Met4p, localizes within thenucleus 4e-050.00128&radic&radic S000006097TRE1YPL176CverifiedPlasma membrane localized protein of unknown function; containssequence similarity to the transferrin receptor 4e-050.00128 S000006246PUF2YPR042CverifiedMember of the PUF protein family, which is defined by thepresence of Pumilio homology domains thatconfer RNA binding activity; preferentiallybinds mRNAs encoding membrane-associatedproteins 4e-050.00128 S000004999VAC7YNL054WverifiedIntegral vacuolar membrane protein involved in vacuoleinheritance and morphology; may function toregulate Fab1p kinase activity 4e-050.00128 S000003905MGM101YJR144WverifiedProtein involved in mitochondrial genome maintenance; componentof the mitochondrial nucleoid, required for therepair of oxidative mtDNA damage 4e-050.00128 S000004932YMR315WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR315W is not an essential gene 4e-050.00128&radic S000003135PMR1YGL167CverifiedHigh affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ andMn2+ transport into Golgi; involved in Ca2+dependent protein sorting and processing;mutations in human homolog ATP2C1 causeacantholytic skin condition Hailey-Haileydisease 4e-050.00128 S000000485DUG2YBR281CuncharacterizedProtein involved in alternative pathway of glutathionedegradation; green fluorescent protein(GFP)-fusion protein localizes to the cytoplasmand nucleus; YBR281C is not an essential gene 4e-050.00128&radic S000001089AAP1YHR047CverifiedArginine/alanine aminopeptidase, overproduction stimulatesglycogen accumulation 4e-050.00128&radic S000004947RLP7YNL002CverifiedNucleolar protein with similarity to large ribosomal subunit L7proteins; constituent of 66S pre-ribosomalparticles; plays an essential role inprocessing of precursors to the large ribosomalsubunit RNAs 4e-050.00128&radic S000002163MED2YDL005CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation 4e-050.00128&radic&radic S000002694YDR286CUncharacterizedHypothetical protein 4e-050.00128 S000002906SEC20YDR498CverifiedMembrane glycoprotein v-SNARE involved in retrograde transportfrom the Golgi to the ER; required for N- andO-glycosylation in the Golgi but not in the ER;forms a complex with the cytosolic Tip20p 4e-050.00128 S000001661STE3YKL178CverifiedReceptor for a factor receptor, transcribed in alpha cells andrequired for mating by alpha cells, couples toMAP kinase cascade to mediate pheromoneresponse; ligand bound receptors areendocytosed and recycled to the plasmamembrane; GPCR 4e-050.00128 S000005603RTS2YOR077WverifiedBasic zinc-finger protein, similar to human and mouse Kin17proteins which are chromatin-associatedproteins involved in UV response and DNAreplication 4e-050.00128&radic S000005506PSF3YOL146WverifiedSubunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), whichis localized to DNA replication origins andimplicated in assembly of the DNA replicationmachinery 4e-050.00128&radic&radic S000004407YLR415CUncharacterizedPutative protein of unknown function; YLR415C is not an essential gene 4e-050.00128&radic S000005228MRPL10YNL284CverifiedMitochondrial ribosomal protein of the large subunit; appearsas two protein spots (YmL10 and YmL18) ontwo-dimensional SDS gels 4e-050.00128 S000003530MRS11YHR005C-AverifiedEssential protein of the mitochondrial intermembrane space,forms a complex with Tim9p (TIM10 complex) thatmediates insertion of hydrophobic proteins atthe inner membrane, has homology to Mrs5p,which is also involved in this process 4e-050.00128&radic S000000478CHK1YBR274WverifiedDNA damage checkpoint effector kinase, mediates mitotic cellcycle arrest via phosphorylation of Pds1p;phosphorylated by checkpoint signal transducerkinase Mec1p; homolog of S. pombe and mammalianChk1 checkpoint kinase 4e-050.00128 S000005543PET127YOR017WverifiedProtein with a role in mitochondrial RNA stability and/orprocessing, located in the mitochondrialmembrane 4e-050.00128 S000003862RSM26YJR101WverifiedMitochondrial ribosomal protein of the small subunit 4e-050.00128&radic S000001607SSH4YKL124WverifiedProtein whose overexpression confers resistance to the growthinhibitor leflunomide; suppressor of shr3mutation 4e-050.00128&radic S000002950PAU10YDR542WuncharacterizedHypothetical protein 4e-050.00128 S000002650AMD2YDR242WverifiedPutative amidase 4e-050.00128 S000003097RSM23YGL129CverifiedMitochondrial ribosomal protein of the small subunit, hassimilarity to mammalian apoptosis mediatorproteins; null mutation prevents induction ofapoptosis by overproduction of metacaspaseMca1p 4e-050.00128&radic&radic&radic S000000483PAF1YBR279WverifiedRNA polymerase II-associated protein, defines a large complexthat is biochemically and functionally distinctfrom the Srb-Mediator form of Pol II holoenzymeand is required for full expression of a subsetof cell cycle-regulated genes 4e-050.00128&radic&radic S000006307PRE2YPR103Wverified20S proteasome beta-type subunit, responsible for thechymotryptic activity of the proteasome 4e-050.00128&radic S000028858YOR293C-AUncharacterizedIdentified by expression profiling and mass spectrometry 4e-050.00128 S000002693ZIP1YDR285WverifiedTransverse filament protein of the synaptonemal complex;required for normal levels of meioticrecombination and pairing between homologouschromosome during meiosis; potential Cdc28psubstrate 4e-050.00128 S000005476MSN1YOL116WverifiedTranscriptional activator involved in regulation of invertaseand glucoamylase expression, invasive growthand pseudohyphal differentiation, iron uptake,chromium accumulation, and response to osmoticstress; localizes to the nucleus 4e-050.00128 S000006347RRP15YPR143WverifiedNucleolar protein, constituent of pre-60S ribosomal particles;required for processing of the 27S pre-rRNA atthe A2 site to yield 5.8S and 25S rRNA 4e-050.00128&radic&radic&radic S000005575RSB1YOR049CverifiedSuppressor of sphingoid long chain base (LCB) sensitivity of anLCB-lyase mutation; putative integral membranetransporter or flippase that may transport LCBsfrom the cytoplasmic side toward theextracytoplasmic side of the membrane 4e-050.00128 S000004295ACO1YLR304CverifiedAconitase, required for the tricarboxylic acid (TCA) cycle andalso independently required for mitochondrialgenome maintenance; component of themitochondrial nucleoid; mutation leads toglutamate auxotrophy 4e-050.00128 S000000107SCT1YBL011WverifiedGlycerol 3-phosphate/dihydroxyacetone phosphate dualsubstrate-specific sn-1 acyltransferase of theglycerolipid biosynthesis pathway, prefers16-carbon fatty acids, similar to Gpt2p, geneis constitutively transcribed 4e-050.00128 S00000