Yfunc lets you browse current and predicted gene functions in yeast

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Prediction of GO:0043634 "polyadenylation-dependent ncRNA catabolism"

GO branch: BP
Number of currently annotated genes: 7

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest Ho:S000002334Ho:S000001341TAP:201PF03828Harbison:MSS11_BUT14IPR002058Giaever:5-fluorouracil_76.9uMHuh:nucleolusHarbison:RTS2_YPDPS01175 S000005475PAP2YOL115WverifiedCatalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), anuclear poly (A) polymerase complex involved inRNA quality control; catalyzes polyadenylationof unmodified tRNAs, and snoRNA and rRNAprecursors; disputed role as a DNA polymerase &radic0.242980.97297&radic&radic S000005243TRF5YNL299WverifiedPoly (A) polymerase involved in nuclear RNA quality controlbased on: homology with Trf4p, geneticinteractions with TRF4 mutants, physicalinteraction with Mtr4p (TRAMP subunit), and bydirect assay; disputed role as a sigma DNApolymerase &radic0.159360.88636&radic&radic&radic S000001710PAP1YKR002WverifiedPoly(A) polymerase, one of three factors required for mRNA3'-end polyadenylation, forms multiproteincomplex with polyadenylation factor I (PF I),also required for mRNA nuclear export; may alsopolyadenylate rRNAs 0.066040.65749 S000002334AIR2YDL175CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p; may regulatemethylation of Npl3p, which modulates Npl3pfunction in mRNA processing and export; hassimilarity to Air1p &radic0.063230.65294&radic S000001111RRP4YHR069CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp41p, Rrp42p,Rrp43p and Dis3p 0.059360.63577&radic&radic S000001341AIR1YIL079CverifiedRING finger protein that interacts with the argininemethyltransferase Hmt1p to regulate methylationof Npl3p, which modulates Npl3p function inmRNA processing and export; has similarity toAir2p &radic0.057850.62714&radic&radic&radic S000006111NAB3YPL190CverifiedSingle stranded DNA binding protein; acidic ribonucleoprotein;required for termination of non-poly(A)transcripts and efficient splicing; interactswith Nrd1p 0.029270.51809 S000003163GCN1YGL195WverifiedPositive regulator of the Gcn2p kinase activity, forms acomplex with Gcn20p; proposed to stimulateGcn2p activation by an uncharged tRNA 0.014210.37811 S000005502RRP40YOL142WverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex 0.00790.30332&radic S000004153MAS1YLR163CverifiedSmaller subunit of the mitochondrial processing protease (MPP),essential processing enzyme that cleaves theN-terminal targeting sequences frommitochondrially imported proteins 0.007070.28651&radic S000004842RRP5YMR229CverifiedProtein required for the synthesis of both 18S and 5.8S rRNA;C-terminal region is crucial for the formationof 18S rRNA and N-terminal region is requiredfor the 5.8S rRNA; component of small ribosomalsubunit (SSU) processosome 0.006680.27452&radic S000005199GIS2YNL255CverifiedProtein with seven cysteine-rich CCHC zinc-finger motifs,similar to human CNBP, proposed to be involvedin the RAS/cAMP signaling pathway 0.00470.20864 S000004390SKI2YLR398CverifiedPutative RNA helicase, involved in exosome mediated 3' to 5'mRNA degradation and translation inhibition ofnon-poly(A) mRNAs; forms complex with Ski3p andSki8p; required for repressing propagation ofdsRNA viruses 0.004650.20696 S000002701SSD1YDR293CverifiedProtein with a role in maintenance of cellular integrity,interacts with components of the TOR pathway;ssd1 mutant of a clinical S. cerevisiae straindisplays elevated virulence 0.00450.20121&radic S000002495SLU7YDR088CverifiedRNA splicing factor, required for ATP-independent portion of2nd catalytic step of spliceosomal RNAsplicing; interacts with Prp18p; contains zincknuckle domain 0.004430.19893 S000004900DSS1YMR287CverifiedRNase, component of the mitochondrial degradosome along withthe ATP-dependent RNA helicase Suv3p; thedegradosome associates with the ribosome andmediates turnover of aberrant or unprocessedRNAs 0.004410.19682&radic S000004106MSL5YLR116WverifiedComponent of the commitment complex, which defines the firststep in the splicing pathway; essential proteinthat interacts with Mud2p and Prp40p, forming abridge between the intron ends; also involvedin nuclear retention of pre-mRNA 0.004320.19411 S000004802SGS1YMR190CverifiedNucleolar DNA helicase of the RecQ family involved inmaintenance of genome integrity, regulateschromosome synapsis and meiotic crossing over;has similarity to human BLM and WRN helicasesimplicated in Bloom and Werner syndromes 0.004110.18386 S000006346YPR142CDubiousHypothetical protein; open reading frame overlaps 5' end of essential RRP15 gene required for ribosomal RNA processing 0.003850.17315&radic&radic S000000939YER137CUncharacterizedHypothetical protein 0.002750.12918 S000002840NPL3YDR432WverifiedRNA-binding protein that carries poly(A)+ mRNA from the nucleusinto the cytoplasm; phosphorylation by Sky1p inthe cytoplasm may promote release of mRNAs 0.002720.12844&radic S000003586MTR4YJL050WverifiedDead-box family ATP dependent helicase required for mRNA exportfrom the nucleus; co-factor of the exosomecomplex, required for 3' end formation of 5.8SrRNA &radic0.002660.12575&radic&radic&radic S000006311YTH1YPR107CverifiedEssential RNA-binding component of cleavage and polyadenylationfactor, contains five zinc fingers; requiredfor pre-mRNA 3'-end processing andpolyadenylation 0.002650.12478 S000001123LRP1YHR081WverifiedSubstrate-specific nuclear cofactor for exosome activity in theprocessing of stable RNAs; required fortelomere length maintenance; homolog ofmammalian nuclear matrix protein C1D involvedin regulation of DNA repair and recombination 0.002410.11571 S000003427SKI6YGR195Wverified3'-to-5' phosphorolytic exoribonuclease that is a subunit ofthe exosome; required for 3' processing of the5.8S rRNA; involved in 3' to 5' mRNAdegradation and translation inhibition ofnon-poly(A) mRNAs 0.002180.10707&radic S000001542MPE1YKL059CverifiedEssential conserved subunit of CPF (cleavage andpolyadenylation factor), plays a role in 3' endformation of mRNA via the specific cleavage andpolyadenylation of pre-mRNA, contains aputative RNA-binding zinc knuckle motif 0.002160.10589 S000002747FCF1YDR339CverifiedEssential nucleolar protein that is a component of the SSU(small subunit) processome involved in thepre-rRNA processing steps of 40S ribosomalsubunit biogenesis; contains a PINc domain;copurifies with Faf1p 0.001960.09696 S000001413YIL151CUncharacterizedPutative protein of unknown function, predicted to contain a PINc (PilT N terminus) domain 0.001930.09576 S000005692SWT1YOR166CuncharacterizedPutative protein of unknown function; predicted to contain aPINc domain (PilT N terminus) 0.001910.09523 S000004355NMD4YLR363CverifiedProtein interacting with Nam7p, may be involved in thenonsense-mediated mRNA decay pathway 0.001810.09036 S000000815PRP22YER013WverifiedDEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase,associates with lariat intermediates before thesecond catalytic step of splicing; mediatesATP-dependent mRNA release from the spliceosomeand unwinds RNA duplexes 0.001720.08647 S000002812RPB7YDR404CverifiedRNA polymerase II subunit B16; forms two subunit dissociablecomplex with Rpb4p 0.001690.08489 S000001066MAS2YHR024CverifiedLarger subunit of the mitochondrial processing protease (MPP),essential processing enzyme that cleaves theN-terminal targeting sequences frommitochondrially imported proteins 0.001670.08391&radic&radic S000003767SUI2YJR007WverifiedAlpha subunit of the translation initiation factor eIF2,involved in the identification of the startcodon; phosphorylation of Ser51 is required forregulation of translation by inhibiting theexchange of GDP for GTP 0.001520.07663 S000001803MLP1YKR095WverifiedMyosin-like protein associated with the nuclear envelope,connects the nuclear pore complex with thenuclear interior; involved with Tel1p intelomere length control; involved with Pml1pand Pml39p in nuclear retention of unsplicedmRNAs 0.001470.074 S000001377NUP159YIL115CverifiedSubunit of the nuclear pore complex that is found exclusivelyon the cytoplasmic side, forms a subcomplexwith Nup82p and Nsp1p, required for mRNA export 0.001460.07361 S000004076SMC4YLR086WverifiedSubunit of the condensin complex, which reorganizes chromosomesduring cell division, forms a stable complexwith Smc2p that has ATP-hydrolyzing andDNA-binding activity and promotes knotting ofcircular DNA; potential Cdc28p substrate 0.00140.0706&radic S000001804YKR096WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and to the cytoplasm; predicted to contain a PINc (PilT N terminus) domain; YKR096W is not an essential gene 0.001370.06964 S000005294PRP2YNR011CverifiedRNA-dependent ATPase in the DEAH-box family, required foractivation of the spliceosome before the firsttransesterification step in RNA splicing 0.001360.0686 S000005206POL2YNL262WverifiedCatalytic subunit of DNA polymerase epsilon, one of the majorchromosomal DNA replication polymerasescharacterized by processivity and proofreadingexonuclease activity; also involved in DNAsynthesis during DNA repair 0.001290.06413 S000000449ISW1YBR245CverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPase thatforms a complex with Ioc2p and Ioc4p toregulate transcription elongation, and acomplex with Ioc3p to repress transcriptioninitiation 0.001240.06136&radic S000005083RLR1YNL139CverifiedSubunit of the THO complex, which is required for efficienttranscription elongation and involved intranscriptional elongation-associatedrecombination; required for LacZ RNA expressionfrom certain plasmids 0.001220.06046 S000002789YRA1YDR381WverifiedNuclear protein that binds to RNA and to Mex67p, required forexport of poly(A)+ mRNA from the nucleus;member of the REF (RNA and export factorbinding proteins) family; another familymember, Yra2p, can substitute for Yra1pfunction 0.00120.05959 S000005195NRD1YNL251CverifiedRNA-binding protein that interacts with the C-terminal domainof the RNA polymerase II large subunit(Rpo21p), required for transcriptiontermination and 3' end maturation ofnonpolyadenylated RNAs 0.001210.05959 S000000122LSM2YBL026WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.00110.05299&radic S000002545HPR1YDR138WverifiedSubunit of THO/TREX complexes that couple transcriptionelongation with mitotic recombination and withmRNA metabolism and export, subunit of an RNAPol II complex; regulates lifespan; involved intelomere maintenance; similar to Top1p 0.001020.04843 S000004284GSP1YLR293CverifiedGTP binding protein (mammalian Ranp homolog) involved in themaintenance of nuclear organization, RNAprocessing and transport; regulated by Prp20p,Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p andKap95p; yeast Gsp2p homolog 0.000960.04318 S000002490RRP8YDR083WverifiedNucleolar protein involved in rRNA processing, pre-rRNAcleavage at site A2; also involved in telomeremaintenance; mutation is synthetically lethalwith a gar1 mutation 0.000910.04156&radic&radic&radic S000001725YKR017CUncharacterizedPutative protein of unknown function; contains a RING finger motif 0.000880.03994 S000003065SRM1YGL097WverifiedNucleotide exchange factor for Gsp1p, localizes to the nucleus,required for nucleocytoplasmic trafficking ofmacromolecules; potentially phosphorylated byCdc28p 0.000840.0381&radic S000002360TRM8YDL201WverifiedSubunit of a tRNA methyltransferase complex composed of Trm8pand Trm82p that catalyzes 7-methylguanosinemodification of tRNA 0.000760.03515 S000000631RRP43YCR035CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp41p, Rrp42p,Rrp4p and Dis3p; required for efficientmaturation of 5.8S, 18S and 25S rRNA 0.000740.03431&radic S000005730DED1YOR204WverifiedATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, requiredfor translation initiation of all yeast mRNAs;mutations in human DEAD-box DBY are a frequentcause of male infertility 0.000730.03417 S000005366TOP1YOL006CverifiedTopoisomerase I, nuclear enzyme that relieves torsional strainin DNA by cleaving and re-sealing thephosphodiester backbone; relaxes bothpositively and negatively supercoiled DNA;functions in replication, transcription, andrecombination 0.000730.03409&radic S000000967PAB1YER165WverifiedPoly(A) binding protein, part of the 3'-end RNA-processingcomplex, mediates interactions between the 5'cap structure and the 3' mRNA poly(A) tail,involved in control of poly(A) tail length,interacts with translation factor eIF-4G 0.000710.03291 S000002600NUP42YDR192CverifiedSubunit of the nuclear pore complex (NPC) that localizesexclusively to the cytoplasmic side; involvedin RNA export, most likely at a terminal step;interacts with Gle1p 0.000690.03226 S000002688RRP45YDR280WverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex 0.000670.03156&radic S000005133SRP1YNL189WverifiedKaryopherin alpha homolog, forms a dimer with karyopherin betaKap95p to mediate import of nuclear proteins,binds the nuclear localization signal of thesubstrate during import; may also play a rolein regulation of protein degradation 0.000660.03128 S000000238HMT1YBR034CverifiedNuclear SAM-dependent mono- and asymmetric argininedimethylating methyltransferase that modifieshnRNPs, including Npl3p and Hrp1p, thusfacilitating nuclear export of these proteins;required for viability of npl3 mutants 0.000660.03109 S000006391RPO26YPR187WverifiedRNA polymerase subunit ABC23, common to RNA polymerases I, II,and III; part of central core; similar tobacterial omega subunit 0.000640.03043 S000006379DPB2YPR175WverifiedSecond largest subunit of DNA polymerase II (DNA polymeraseepsilon), required for normal yeast chromosomalreplication; expression peaks at the G1/S phaseboundary; potential Cdc28p substrate 0.000630.03022 S000005552BUB3YOR026WverifiedKinetochore checkpoint WD40 repeat protein that localizes tokinetochores during prophase and metaphase,delays anaphase in the presence of unattachedkinetochores; forms complexes with Mad1p-Bub1pand with Cdc20p, binds Mad2p and Mad3p 0.000630.03004 S000004029RIC1YLR039CverifiedProtein involved in retrograde transport to the cis-Golginetwork; forms heterodimer with Rgp1p that actsas a GTP exchange factor for Ypt6p; involved intranscription of rRNA and ribosomal proteingenes 0.000610.02946 S000003327RRP46YGR095CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex 0.000610.02921&radic S000003506TAF1YGR274CverifiedTFIID subunit (145 kDa), involved in RNA polymerase IItranscription initiation, has histoneacetyltransferase activity, involved inpromoter binding and G1/S progression 0.00060.02883&radic S000000120NCL1YBL024WverifiedS-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase,methylates cytosine to m5C at several positionsin tRNAs and intron-containing pre-tRNAs;similar to Nop2p and human proliferationassociated nucleolar protein p120 0.000590.02863 S000006067NOP53YPL146CverifiedNucleolar protein; involved in biogenesis of the 60S subunit ofthe ribosome; interacts with rRNA processingfactors Cbf5p and Nop2p; null mutant is viablebut growth is severely impaired 0.000560.02682 S000003088PRP43YGL120CverifiedRNA helicase in the DEAH-box family, functions in both RNApolymerase I and polymerase II transcriptmetabolism, involved in release of thelariat-intron from the spliceosome 0.000550.02659&radic S000005933RRP12YPL012WverifiedProtein required for export of the ribosomal subunits;associates with the RNA components of thepre-ribosomes; contains HEAT-repeats 0.000560.02659&radic S000002269RRP42YDL111CverifiedProtein involved in rRNA processing; component of the exosome3->5 exonuclease complex with Rrp4p, Rrp41p,Rrp43p and Dis3p 0.000550.0265&radic&radic S000003390MTR3YGR158Cverified3'5' exoribonuclease, exosome subunit; nucleolar proteininvolved in export of mRNA and ribosomalsubunits; homologous to the E. coli exonucleaseRNase PH 0.000540.0261 S000000346MAK5YBR142WverifiedEssential nucleolar protein, putative DEAD-box RNA helicaserequired for maintenance of M1 dsRNA virus;involved in biogenesis of large (60S) ribosomalsubunits 0.000540.02596&radic&radic S000003011DST1YGL043WverifiedGeneral transcription elongation factor TFIIS, enables RNApolymerase II to read through blocks toelongation by stimulating cleavage of nascenttranscripts stalled at transcription arrestsites 0.000530.02579 S000000973RAD3YER171Wverified5' to 3' DNA helicase, involved in nucleotide excision repairand transcription; subunit of RNA polymerase IItranscription initiation factor TFIIH; subunitof Nucleotide Excision Repair Factor 3 (NEF3);homolog of human XPD protein 0.000520.02525 S000005965YPL044CDubiousHypothetical protein 0.000510.0246&radic S000004520IMD4YML056CverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 0.000510.0246 S000005056DBP2YNL112WverifiedEssential ATP-dependent RNA helicase of the DEAD-box proteinfamily, involved in nonsense-mediated mRNAdecay and rRNA processing 0.000490.02252 S000005923SNF8YPL002CverifiedComponent of the ESCRT-II complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; appears to be functionallyrelated to SNF7; involved in glucosederepression 0.000490.02252 S000001411MLP2YIL149CverifiedMyosin-like protein associated with the nuclear envelope,connects the nuclear pore complex with thenuclear interior; involved in the Tel1p pathwaythat controls telomere length 0.000490.02252 S000005307YNR024WUncharacterizedHypothetical protein 0.000490.02211 S000001129YHR087WVerifiedProtein involved in RNA metabolism, one of two yeast homologs (with Sdo1p/Ylr022cp) of the human protein SBDS responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome, also conserved in Archaea 0.000470.02053 S000005143GCR2YNL199CverifiedTranscriptional activator of genes involved in glycolysis;interacts and functions with the DNA-bindingprotein Gcr1p 0.000460.01984 S000005480RPL18AYOL120CverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl18Bp and has similarity to ratL18 ribosomal protein; intron of RPL18Apre-mRNA forms stem-loop structures that are atarget for Rnt1p cleavage leading todegradation 0.000460.01955 S000004732STO1YMR125WverifiedLarge subunit of the nuclear mRNA cap-binding protein complex,interacts with Npl3p to carry nuclear poly(A)+mRNA to cytoplasm; also involved in nuclearmRNA degradation and telomere maintenance;orthologous to mammalian CBP80 0.000450.01955 S000006314RPC40YPR110CverifiedRNA polymerase subunit, common to RNA polymerase I and III 0.000440.0189&radic S000002555KGD2YDR148CverifiedDihydrolipoyl transsuccinylase, a component of themitochondrial alpha-ketoglutarate dehydrogenasecomplex, which catalyzes a step in thetricarboxylic acid (TCA) cycle, the oxidativedecarboxylation of alpha-ketoglutarate tosuccinyl-CoA 0.000440.0189 S000000435SWC5YBR231CuncharacterizedProtein of unknown function, component of the SWR1 complex,which exchanges histone variant H2AZ (Htz1p)for chromatin-bound histone H2A 0.000440.01888 S000000968DNF1YER166WverifiedAminophospholipid translocase (flippase) that localizesprimarily to the plasma membrane; contributesto endocytosis, protein transport and cellpolarity; type 4 P-type ATPase 0.000430.01861 S000001302APQ12YIL040WverifiedProtein involved in nucleocytoplasmic transport of mRNA 0.000430.01857 S000003062PAN2YGL094CverifiedEssential subunit of the Pan2p-Pan3p poly(A)-ribonucleasecomplex, which acts to control poly(A) taillength and regulate the stoichiometry andactivity of postreplication repair complexes 0.000420.01847 S000004181PEX13YLR191WverifiedIntegral peroxisomal membrane receptor for the PTS1 peroxisomalmatrix protein signal recognition factor Pex5p,required for the translocation of peroxisomalmatrix proteins, also interacts with Pex7p andPex14p, contains a C-terminal SH3 domain 0.000420.01847 S000004093CDC45YLR103CverifiedDNA replication initiation factor; recruited to MCM pre-RCcomplexes at replication origins; promotesrelease of MCM from Mcm10p, recruits elongationmachinery; mutants in human homolog may causevelocardiofacial and DiGeorge syndromes 0.000420.01831 S000003054MAD1YGL086WverifiedCoiled-coil protein involved in the spindle-assemblycheckpoint; phosphorylated by Mps1p uponcheckpoint activation which leads to inhibitionof the activity of the anaphase promotingcomplex; forms a complex with Mad2p 0.000420.01796 S000004650NUP116YMR047CverifiedSubunit of the nuclear pore complex (NPC) that is localized toboth sides of the pore; contains a repetitiveGLFG motif that interacts with mRNA exportfactor Mex67p and with karyopherin Kap95p;homologous to Nup100p 0.000410.01781 S000003818CDC8YJR057WverifiedThymidylate and uridylate kinase, functions in de novobiosynthesis of pyrimidinedeoxyribonucleotides; converts dTMP to dTDP anddUMP to dUTP; essential for mitotic and meioticDNA replication; homologous to S. pombe Tmp1p 0.000410.01781 S000004577ZDS2YML109WverifiedProtein that interacts with silencing proteins at the telomere,involved in transcriptional silencing; paralogof Zds1p 0.000410.01754 S000004470SPT5YML010WverifiedProtein that forms a complex with Spt4p and mediates bothactivation and inhibition of transcriptionelongation; Spt4p-Spt5p complex also plays arole in pre-mRNA processing 0.000410.01754 S000002242SUB2YDL084WverifiedComponent of the TREX complex required for nuclear mRNA export;member of the DEAD-box RNA helicase superfamilyand is involved in early and late steps ofspliceosome assembly; homolog of the humansplicing factor hUAP56 0.000410.01754 S000005194RAD50YNL250WverifiedSubunit of MRX complex, with Mre11p and Xrs2p, involved inprocessing double-strand DNA breaks invegetative cells, initiation of meiotic DSBs,telomere maintenance, and nonhomologous endjoining 0.00040.01709 S000004362ARC18YLR370CverifiedSubunit of the ARP2/3 complex, which is required for themotility and integrity of cortical actinpatches 0.00040.01671 S000003719MNN11YJL183WverifiedSubunit of a Golgi mannosyltransferase complex that alsocontains Anp1p, Mnn9p, Mnn10p, and Hoc1p, andmediates elongation of the polysaccharidemannan backbone; has homology to Mnn10p 0.00040.01671 S000003397MRPS35YGR165WverifiedMitochondrial ribosomal protein of the small subunit 0.00040.01671 S000004415ATG17YLR423CverifiedProtein that interacts with and is required for activation ofApg1p protein kinase; involved in autophagy butnot in the Cvt (cytoplasm to vacuole targeting)pathway 0.00040.01671 S000005169CNM67YNL225CverifiedComponent of the spindle pole body outer plaque; required forspindle orientation and mitotic nuclearmigration 0.00040.01671 S000004886ZDS1YMR273CverifiedProtein that interacts with silencing proteins at the telomere,involved in transcriptional silencing; has arole in localization of Bcy1p, a regulatorysubunit of protein kinase A; implicated in mRNAnuclear export 0.00040.01652 S000005176CSL4YNL232WverifiedSubunit of the exosome, which is an essential complex presentin both nucleus and cytoplasm that mediates RNAprocessing and degradation 0.00040.01592&radic S000003288RSC1YGR056WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; containstwo essential bromodomains, a bromo-adjacenthomology (BAH) domain, and an AT hook 0.00040.01592 S000003660LSM1YJL124CverifiedLsm (Like Sm) protein; forms heteroheptameric complex (withLsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p)involved in degradation of cytoplasmic mRNAs 0.000390.01592 S000000455MRPS5YBR251WverifiedMitochondrial ribosomal protein of the small subunit 0.000390.01592 S000004683CTF18YMR078CverifiedSubunit of a complex with Ctf8p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion; may have overlappingfunctions with Rad24p in the DNA damagereplication checkpoint 0.000380.01452 S000001927SMC2YFR031CverifiedComponent of the condensin complex, essential SMC chromosomalATPase family member that forms a complex withSmc4p to form the active ATPase; Smc2p/Smc4pcomplex binds DNA, possibly in the cleft formedby the coiled-coil of the folded dimer 0.000380.01452 S000002718SUM1YDR310CverifiedTranscriptional repressor required for mitotic repression ofmiddle sporulation-specific genes; involved intelomere maintenance, regulated by thepachytene checkpoint 0.000380.01452 S000000301VPS15YBR097WverifiedMyristoylated serine/threonine protein kinase involved invacuolar protein sorting; functions as amembrane-associated complex with Vps34p; activeform recruits Vps34p to the Golgi membrane;interacts with the GDP-bound form of Gpa1p 0.000380.01452 S000001238NVJ1YHR195WverifiedNuclear envelope protein that interacts with the vacuolarmembrane protein Vac8p to promote formation ofnucleus-vacuole junctions during piecemealmicroautophagy of the nucleus (PMN) 0.000380.01452 S000000322TEF2YBR118WverifiedTranslational elongation factor EF-1 alpha; also encoded byTEF1; functions in the binding reaction ofaminoacyl-tRNA (AA-tRNA) to ribosomes 0.000380.01408 S000000602RVS161YCR009CverifiedAmphiphysin-like lipid raft protein; subunit of a complex(Rvs161p-Rvs167p) that regulates polarizationof the actin cytoskeleton, endocytosis, cellpolarity, cell fusion and viability followingstarvation or osmotic stress 0.000380.01408 S000002536SAC6YDR129CverifiedFimbrin, actin-bundling protein; cooperates with Scp1p(calponin/transgelin) in the organization andmaintenance of the actin cytoskeleton 0.000370.0138 S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.000370.0135&radic&radic S000003406CBP4YGR174CverifiedMitochondrial protein required for assembly of ubiquinolcytochrome-c reductase complex (cytochrome bc1complex); interacts with Cbp3p and function ispartially redundant with that of Cbp3p 0.000370.0135 S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling 0.000360.01319&radic S000000770IES6YEL044WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.000360.01319 S000004949HRB1YNL004WverifiedPoly(A+) RNA-binding protein, involved in the export of mRNAsfrom the nucleus to the cytoplasm; similar toGbp2p and Npl3p 0.000360.01317 S000005831ISW2YOR304WverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPasecomponent that, with Itc1p, forms a complexrequired for repression of a-specific genes,INO1, and early meiotic genes during mitoticgrowth 0.000360.01317 S000004172SWI6YLR182WverifiedTranscription cofactor, forms complexes with DNA-bindingproteins Swi4p and Mbp1p to regulatetranscription at the G1/S transition; involvedin meiotic gene expression; localizationregulated by phosphorylation; potential Cdc28psubstrate 0.000360.01308 S000000682CSM1YCR086WverifiedNucleolar protein that forms a complex with Lrs4p which bindsMam1p at kinetochores during meiosis I tomediate accurate chromosome segregation, may beinvolved in premeiotic DNA replication;possible role in telomere maintenance 0.000360.01291&radic&radic&radic S000004424IMD3YLR432WverifiedInosine monophosphate dehydrogenase, catalyzes the first stepof GMP biosynthesis, member of a four-genefamily in S. cerevisiae, constitutivelyexpressed 0.000360.01291 S000003336SRB5YGR104CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation; involved intelomere maintenance 0.000360.01289 S000005187SLA2YNL243WverifiedTransmembrane actin-binding protein involved in membranecytoskeleton assembly and cell polarization;adaptor protein that links actin to clathrinand endocytosis; present in the actin corticalpatch of the emerging bud tip; dimer in vivo 0.000350.01279 S000005051YAF9YNL107WverifiedSubunit of both the NuA4 histone H4 acetyltransferase complexand the SWR1 complex, may function toantagonize silencing near telomeres; interactsdirectly with Swc4p, has homology to humanleukemogenic protein AF9, contains a YEATSdomain 0.000350.01275 S000006305SNT309YPR101WverifiedComponent of NineTeen complex (NTC) containing Prp19p involvedin mRNA splicing, interacts physically andgenetically with Prp19p 0.000350.01243 S000004738RRB1YMR131CverifiedEssential nuclear protein involved in early steps of ribosomebiogenesis; physically interacts with theribosomal protein Rpl3p 0.000350.01243&radic S000004075ARP6YLR085CverifiedActin-related protein that binds nucleosomes; a component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.000350.01243 S000004329VRP1YLR337CverifiedProline-rich actin-associated protein involved in cytoskeletalorganization and cytokinesis; related tomammalian Wiskott-Aldrich syndrome protein(WASP)-interacting protein (WIP) 0.000350.01243 S000001596RAD27YKL113Cverified5' to 3' exonuclease, 5' flap endonuclease, required forOkazaki fragment processing and maturation aswell as for long-patch base-excision repair;member of the S. pombe RAD2/FEN1 family 0.000350.01243 S000003651ASF1YJL115WverifiedNucleosome assembly factor, involved in chromatin assembly anddisassembly, anti-silencing protein that causesderepression of silent loci when overexpressed 0.000350.01243 S000004349RSC2YLR357WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; involvedin telomere maintenance 0.000350.01243 S000004745PSO2YMR137CverifiedRequired for a post-incision step in the repair of DNA singleand double-strand breaks that result frominterstrand crosslinks produced by a variety ofmono- and bi-functional psoralen derivatives;induced by UV-irradiation 0.000350.01243&radic S000000913SWI4YER111CverifiedDNA binding component of the SBF complex (Swi4p-Swi6p), atranscriptional activator that in concert withMBF (Mbp1-Swi6p) regulates late G1-specifictranscription of targets including cyclins andgenes required for DNA synthesis and repair 0.000350.01235 S000004422SEN1YLR430WverifiedPutative helicase required for RNA polymerase II transcriptiontermination and processing of RNAs; homolog ofSenataxin which causes Ataxia-OculomotorApraxia 2 and a dominant form of amyotrophiclateral sclerosis 0.000350.01235 S000003322UTP22YGR090WuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.000340.01229&radic S000004597MSC1YML128CverifiedProtein of unknown function; mutant is defective in directingmeiotic recombination events to homologouschromatids; the authentic, non-tagged proteinis detected in highly purified mitochondria inhigh-throughput studies 0.000340.012 S000003063VPS45YGL095CverifiedProtein of the Sec1p/Munc-18 family, essential for vacuolarprotein sorting; required for the function ofPep12p and the early endosome/late Golgi SNARETlg2p; essential for fusion of Golgi-derivedvesicles with the prevacuolar compartment 0.000340.012 S000000039CDC24YAL041WverifiedGuanine nucleotide exchange factor (GEF or GDP-release factor)for Cdc42p; required for polarity establishmentand maintenance, and mutants have morphologicaldefects in bud formation and shmooing 0.000340.012 S000001508PAN3YKL025CverifiedEssential subunit of the Pan2p-Pan3p poly(A)-ribonucleasecomplex, which acts to control poly(A) taillength and regulate the stoichiometry andactivity of postreplication repair complexes 0.000340.01191&radic S000005527RRP6YOR001WverifiedExonuclease component of the nuclear exosome; contributes tothe quality-control system that retains anddegrades aberrant mRNAs in the nucleus &radic0.000330.01172&radic&radic&radic S000000298PBY1YBR094WuncharacterizedP-body associated protein 0.000330.01172&radic S000005606DIA2YOR080WverifiedOrigin-binding F-box protein that forms an SCF ubiquitin ligasecomplex with Skp1p and Cdc53p; plays a role inDNA replication, involved in invasive andpseudohyphal growth 0.000330.01155&radic&radic S000005028END3YNL084CverifiedEH domain-containing protein involved in endocytosis, actincytoskeletal organization and cell wallmorphogenesis; forms a complex with Sla1p andPan1p 0.000330.01143&radic S000005032TOP2YNL088WverifiedEssential type II topoisomerase, relieves torsional strain inDNA by cleaving and re-sealing thephosphodiester backbone of both positively andnegatively supercoiled DNA; cleavescomplementary strands; localizes to axial coresin meiosis 0.000330.01143 S000001073RRM3YHR031CverifiedDNA helicase involved in rDNA replication and Ty1transposition; relieves replication fork pausesat telomeric regions; structurally andfunctionally related to Pif1p 0.000330.01137 S000000325GRS1YBR121CverifiedCytoplasmic and mitochondrial glycyl-tRNA synthase that ligatesglycine to the cognate anticodon bearing tRNA;transcription termination factor that mayinteract with the 3'-end of pre-mRNA to promote3'-end formation 0.000330.01128 S000002767VID21YDR359CverifiedComponent of the NuA4 histone acetyltransferase complex 0.000330.01128 S000004920UBP15YMR304WverifiedUbiquitin-specific protease that may play a role in ubiquitinprecursor processing 0.000330.01128 S000001234CTF8YHR191CverifiedSubunit of a complex with Ctf18p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion 0.000330.01084 S000002299RPO21YDL140CverifiedRNA polymerase II largest subunit B220, part of central core;phosphorylation of C-terminal heptapeptiderepeat domain regulates association withtranscription and splicing factors; similar tobacterial beta-prime 0.000320.01084 S000005853MYO2YOR326WverifiedOne of two type V myosin motors (along with MYO4) involved inactin-based transport of cargos; required forthe polarized delivery of secretory vesicles,the vacuole, late Golgi elements, peroxisomes,and the mitotic spindle 0.000320.01046 S000003626DPB11YJL090CverifiedEssential BRCT repeat protein, required on the prereplicativecomplex at replication origins for loading DNApolymerases to initiate DNA synthesis, alsorequired for S/M checkpoint control 0.000320.01041 S000003548RPC17YJL011CverifiedRNA polymerase III subunit C17; physically interacts with C31,C11, and TFIIIB70; may be involved in therecruitment of pol III by the preinitiationcomplex 0.000320.01041 S000004187SIK1YLR197WverifiedEssential evolutionarily-conserved nucleolar protein componentof the box C/D snoRNP complexes that direct2'-O-methylation of pre-rRNA during itsmaturation; overexpression causes spindleorientation defects 0.000310.01013&radic S000001387KGD1YIL125WverifiedComponent of the mitochondrial alpha-ketoglutaratedehydrogenase complex, which catalyzes a keystep in the tricarboxylic acid (TCA) cycle, theoxidative decarboxylation ofalpha-ketoglutarate to form succinyl-CoA 0.000320.01013 S000002467MAK21YDR060WverifiedConstituent of 66S pre-ribosomal particles, required for large(60S) ribosomal subunit biogenesis; involved innuclear export of pre-ribosomes; required formaintenance of dsRNA virus; homolog of humanCAATT-binding protein 0.000320.01013&radic&radic S000004363ROM2YLR371WverifiedGDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutationsare synthetically lethal with mutations inrom1, which also encodes a GEP 0.000310.00983 S000002419RPL4BYDR012WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl4Ap and has similarity to E.coli L4 and rat L4 ribosomal proteins 0.000310.00983 S000001340THS1YIL078WverifiedThreonyl-tRNA synthetase, essential cytoplasmic protein 0.000310.00983&radic&radic S000005667ARP8YOR141CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes 0.000310.00983 S000000818BIM1YER016WverifiedMicrotubule-binding protein that together with Kar9p makes upthe cortical microtubule capture site anddelays the exit from mitosis when the spindleis oriented abnormally 0.000310.00983 S000004527MFT1YML062CverifiedSubunit of the THO complex, which is a nuclear complexcomprised of Hpr1p, Mft1p, Rlr1p, and Thp2p,that is involved in transcription elongationand mitotic recombination; involved in telomeremaintenance 0.000310.00936 S000001733RPC37YKR025WverifiedRNA polymerase III subunit C37 0.000310.00936 S000002905ITR1YDR497CverifiedMyo-inositol transporter with strong similarity to the minormyo-inositol transporter Itr2p, member of thesugar transporter superfamily; expression isrepressed by inositol and choline via Opi1p andderepressed via Ino2p and Ino4p 0.000310.00936&radic S000005356YNR073CUncharacterizedHypothetical protein 0.000310.00936 S000001756NAP1YKR048CverifiedProtein that interacts with mitotic cyclin Clb2p; required forthe regulation of microtubule dynamics duringmitosis; controls bud morphogenesis; involvedin the transport of H2A and H2B histones to thenucleus 0.00030.00917 S000003121PEX14YGL153WverifiedPeroxisomal membrane protein that is a central component of theperoxisomal protein import machinery, interactswith PTS1 (Pex5p) and PTS2 (Pex7p) peroxisomalmatrix protein signal recognition factors andmembrane receptor Pex13p 0.00030.00917 S000000514STP22YCL008CverifiedComponent of the ESCRT-I complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome; homologous to the mouse and humanTsg101 tumor susceptibility gene; mutantsexhibit a Class E Vps phenotype 0.00030.00916 S000004903HAS1YMR290CverifiedATP-dependent RNA helicase; localizes to both the nuclearperiphery and nucleolus; highly enriched innuclear pore complex fractions; constituent of66S pre-ribosomal particles 0.00030.00905 S000003095SOH1YGL127CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; involved in telomeremaintenance; conserved with other metazoanMED31 subunits 0.00030.00886 S000003797HUL4YJR036CverifiedProtein with similarity to hect domain E3 ubiquitin-proteinligases, not essential for viability 0.00030.00886 S000001789RPF2YKR081CverifiedEssential protein involved in the processing of pre-rRNA andthe assembly of the 60S ribosomal subunit;interacts with ribosomal protein L11; localizespredominantly to the nucleolus; constituent of66S pre-ribosomal particles 0.00030.00843&radic S000005820RRS1YOR294WverifiedEssential protein that binds ribosomal protein L11 and isrequired for nuclear export of the 60Spre-ribosomal subunit during ribosomebiogenesis; mouse homolog shows alteredexpression in Huntington's disease model mice 0.00030.00843 S000004837MRE11YMR224CverifiedSubunit of a complex with Rad50p and Xrs2p (RMX complex) thatfunctions in repair of DNA double-strand breaksand in telomere stability, exhibits nucleaseactivity that appears to be required for RMXfunction; widely conserved 0.000290.00834 S000005372HTZ1YOL012CverifiedHistone variant H2AZ, exchanged for histone H2A in nucleosomesby the SWR1 complex; involved intranscriptional regulation through preventionof the spread of silent heterochromatin 0.000290.00789 S000001790NUP133YKR082WverifiedSubunit of the Nup84p subcomplex of the nuclear pore complex(NPC), localizes to both sides of the NPC,required to establish a normalnucleocytoplasmic concentration gradient of theGTPase Gsp1p 0.000290.00789 S000000483PAF1YBR279WverifiedRNA polymerase II-associated protein, defines a large complexthat is biochemically and functionally distinctfrom the Srb-Mediator form of Pol II holoenzymeand is required for full expression of a subsetof cell cycle-regulated genes 0.000290.00789 S000004339KAP95YLR347CverifiedKaryopherin beta, forms a dimeric complex with Srp1p (Kap60p)that mediates nuclear import of cargo proteinsvia a nuclear localization signal (NLS),interacts with nucleoporins to guide transportacross the nuclear pore complex 0.000290.00789 S000004045SPT8YLR055CverifiedSubunit of the SAGA transcriptional regulatory complex but notpresent in SAGA-like complex SLIK/SALSA,required for SAGA-mediated inhibition at somepromoters 0.000290.00762 S000004844PEP5YMR231WverifiedPeripheral vacuolar membrane protein required for proteintrafficking and vacuole biogenesis; formscomplex with Pep3p that promotes vesiculardocking/fusion reactions in conjunction withSNARE proteins, also interacts with Pep7p 0.000290.00762 S000004918ADH2YMR303CverifiedGlucose-repressible alcohol dehydrogenase II, catalyzes theconversion of ethanol to acetaldehyde; involvedin the production of certain carboxylateesters; regulated by ADR1 0.000290.00762 S000005671PNO1YOR145CverifiedEssential nucleolar protein required for pre-18S rRNAprocessing, interacts with Dim1p, an 18S rRNAdimethyltransferase, and also with Nob1p, whichis involved in proteasome biogenesis; containsa KH domain 0.000290.00762 S000004467ERG6YML008CverifiedDelta(24)-sterol C-methyltransferase, converts zymosterol tofecosterol in the ergosterol biosyntheticpathway by methylating position C-24; localizedto both lipid particles and mitochondrial outermembrane 0.000290.00762 S000002160NHP10YDL002CverifiedProtein related to mammalian high mobility group proteins;likely component of the INO80 complex, which isan ATP-dependent chromatin-remodeling complex 0.000290.00762 S000006005BRO1YPL084WverifiedCytoplasmic class E vacuolar protein sorting (VPS) factor thatcoordinates deubiquitination in themultivesicular body (MVB) pathway by recruitingDoa4p to endosomes 0.000280.00758 S000004984BDP1YNL039WverifiedEssential subunit of RNA polymerase III transcription factor(TFIIIB), which is involved in transcription ofgenes encoding tRNAs, 5S rRNA, U6 snRNA, andother small RNAs 0.000280.0073 S000002544RGP1YDR137WverifiedSubunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) thatcatalyzes nucleotide exchange on Ypt6p 0.000280.00706 S000003863VPS25YJR102CverifiedComponent of the ESCRT-II complex, which is involved inubiquitin-dependent sorting of proteins intothe endosome 0.000280.00706 S000003796RAD26YJR035WverifiedProtein involved in transcription-coupled repair nucleotideexcision repair of UV-induced DNA lesions;homolog of human CSB protein 0.000280.00706 S000004410CDC73YLR418CverifiedConstituent of Paf1 complex with RNA polymerase II, Paf1p,Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinctfrom Srb-containing Pol II complexes; requiredfor expression of certain genes, modificationof some histones, and telomere maintenance 0.000270.00681 S000006395QCR2YPR191WverifiedSubunit 2 of the ubiquinol cytochrome-c reductase complex,which is a component of the mitochondrial innermembrane electron transport chain;transcription is regulated by Hap1p,Hap2p/Hap3p, and heme 0.000270.00681 S000005381DIS3YOL021CverifiedNucleolar exosome component, involved in rRNA processing andRNA degradation, binds Gsp1p/Ran and enhancesthe GEF activity of Srm1p, implicated inmitotic control, homologous to the E. coliRNase R of the RNase II family &radic0.000270.00669&radic&radic&radic&radic S000004409VPS36YLR417WverifiedComponent of the ESCRT-II complex; contains the GLUE (GRAM LikeUbiquitin binding in EAP45) domain which isinvolved in interactions with ESCRT-I andubiquitin-dependent sorting of proteins intothe endosome 0.000270.00653&radic S000004252YPT6YLR262CverifiedGTPase, Ras-like GTP binding protein involved in the secretorypathway, required for fusion ofendosome-derived vesicles with the late Golgi,maturation of the vacuolar carboxypeptidase Y;has similarity to the human GTPase, Rab6 0.000270.00653 S000003746PEX2YJL210WverifiedRING-finger peroxin, peroxisomal membrane protein with aC-terminal zinc-binding RING domain, formsputative translocation subcomplex with Pex10pand Pex12p which functions in peroxisomalmatrix protein import 0.000270.00615 S000006394RPC82YPR190CverifiedRNA polymerase III subunit C82 0.000270.00615 S000002430SES1YDR023WverifiedCytosolic seryl-tRNA synthetase, class II aminoacyl-tRNAsynthetase that aminoacylates tRNA(Ser),displays tRNA-dependent amino acid recognitionwhich enhances discrimination of the serinesubstrate, interacts with peroxin Pex21p 0.000270.00615 S000004682VPS20YMR077CverifiedMyristoylated subunit of ESCRTIII, the endosomal sortingcomplex required for transport of transmembraneproteins into the multivesicular body pathwayto the lysosomal/vacuolar lumen; cytoplasmicprotein recruited to endosomal membranes 0.000260.00555 S000005602SKI7YOR076CverifiedAntiviral adaptor protein that mediates interactions via itsN-terminus between the exosome and Ski complex(Ski2p, Ski3p, Ski8p) which operate in the3'-to-5' mRNA-decay pathway; cytoplasmicprotein required for degrading nonstop mRNAs 0.000260.00555 S000002309RPC53YDL150WverifiedRNA polymerase III subunit C53 0.000260.00555 S000002452RPC11YDR045CverifiedRNA polymerase III subunit C11; mediates pol III RNA cleavageactivity and is important for termination oftranscription 0.000260.00555 S000000673PAT1YCR077CverifiedTopoisomerase II-associated deadenylation-dependentmRNA-decapping factor; also required forfaithful chromosome transmission, maintenanceof rDNA locus stability, and protection of mRNA3'-UTRs from trimming; functionally linked toPab1p 0.000260.00555 S000004494RAD52YML032CverifiedProtein that stimulates strand exchange by facilitating Rad51pbinding to single-stranded DNA; annealscomplementary single-stranded DNA; involved inthe repair of double-strand breaks in DNAduring vegetative growth and meiosis 0.000260.00555 S000004925PSE1YMR308CverifiedKaryopherin/importin that interacts with the nuclear porecomplex; acts as the nuclear import receptorfor specific proteins, including Pdr1p, Yap1p,Ste12p, and Aft1p 0.000260.00555 S000004312MMS22YLR320WverifiedProtein involved in resistance to ionizing radiation; acts withMms1p in a repair pathway that may be involvedin resolving replication intermediates orpreventing the damage caused by blockedreplication forks 0.000260.00549 S000004138PEP3YLR148WverifiedVacuolar peripheral membrane protein that promotes vesiculardocking/fusion reactions in conjunction withSNARE proteins, required for vacuolarbiogenesis, forms complex with Pep5p thatmediates protein transport to the vacuole 0.000260.00549 S000005738STE4YOR212WverifiedG protein beta subunit, forms a dimer with Ste18p to activatethe mating signaling pathway, forms aheterotrimer with Gpa1p and Ste18p to dampensignaling; may recruit Rho1p to the polarizedgrowth site during mating; contains WD40repeats 0.000250.00521 S000001351YIL089WUncharacterizedHypothetical protein 0.000240.00455&radic S000004476TRM9YML014WverifiedtRNA methyltransferase, catalyzes the esterification ofmodified uridine nucleotides in tRNAs, creating5-methylcarbonylmethyluridine in tRNA(Arg3) and5-methylcarbonylmethyl-2-thiouridine intRNA(Glu); may have a role in stress response 0.000240.00428 S000004352VPS38YLR360WverifiedPart of a Vps34p phosphatidylinositol 3-kinase complex thatfunctions in carboxypeptidase Y (CPY) sorting;binds Vps30p and Vps34p to promote productionof phosphatidylinositol 3-phosphate (PtdIns3P)which stimulates kinase activity 0.000240.00412&radic S000005095RPC31YNL151CverifiedRNA polymerase III subunit C31; contains HMG-like C-terminaldomain 0.000230.00403 S000000286UBC4YBR082CverifiedUbiquitin-conjugating enzyme that mediates degradation ofshort-lived and abnormal proteins; interactswith E3-CaM in ubiquitinating calmodulin;interacts with many SCF ubiquitin proteinligases; component of the cellular stressresponse 0.000230.00403 S000001780SIS2YKR072CverifiedNegative regulatory subunit of the protein phosphatase 1 Ppz1p;involved in ion homeostasis and cell cycleprogression 0.000230.00403&radic&radic S000000058GDH3YAL062WverifiedNADP(+)-dependent glutamate dehydrogenase, synthesizesglutamate from ammonia and alpha-ketoglutarate;rate of alpha-ketoglutarate utilization differsfrom Gdh1p; expression regulated by nitrogenand carbon sources 0.000230.00403&radic&radic S000005708RPS30BYOR182CverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps30Ap and has similarity to ratS30 ribosomal protein 0.000230.00396&radic&radic S000004305SPH1YLR313CverifiedProtein involved in shmoo formation and bipolar bud siteselection; homologous to Spa2p, localizes tosites of polarized growth in a cell cycledependent- and Spa2p-dependent manner,interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p 0.000230.00385&radic&radic S000001052RPL27AYHR010WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl27Bp and has similarity to ratL27 ribosomal protein 0.000230.00385&radic&radic&radic S000003722MNN5YJL186WverifiedAlpha-1,2-mannosyltransferase, responsible for addition of thesecond alpha-1,2-linked mannose of the brancheson the mannan backbone of oligosaccharides,localizes to an early Golgi compartment 0.000230.00385&radic&radic S000002161MCD1YDL003WverifiedEssential protein required for sister chromatid cohesion inmitosis and meiosis; subunit of the cohesincomplex; expression is cell cycle regulated andpeaks in S phase 0.000230.00376&radic S000005809YOR283WUncharacterizedPutative protein of unknown function with some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene 0.000230.00376&radic S000000459YBR255WUncharacterizedProtein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.000230.0037&radic&radic S000001313MMF1YIL051CverifiedMitochondrial protein involved in maintenance of themitochondrial genome 0.000230.0037&radic&radic S000000070ADE1YAR015WverifiedN-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR)synthetase, required for 'de novo' purinenucleotide biosynthesis; red pigmentaccumulates in mutant cells deprived of adenine 0.000230.0037&radic S000002741YDR333CUncharacterizedHypothetical protein 0.000230.00363&radic&radic S000000123RPL19BYBL027WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl19Ap and has similarity to ratL19 ribosomal protein; rpl19a and rpl19b singlenull mutations result in slow growth, while thedouble null mutation is lethal 0.000230.00363&radic S000006082BEM4YPL161CverifiedProtein involved in establishment of cell polarity and budemergence; interacts with the Rho1p smallGTP-binding protein and with the Rho-typeGTPase Cdc42p; involved in maintenance ofproper telomere length 0.000230.00363 S000005724BFR1YOR198CverifiedComponent of mRNP complexes associated with polyribosomes;implicated in secretion and nuclearsegregation; multicopy suppressor of BFA(Brefeldin A) sensitivity 0.000230.00363&radic&radic S000005779NAT5YOR253WverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.000230.00358&radic&radic S000004445RIF2YLR453CverifiedProtein that binds to the Rap1p C-terminus and actssynergistically with Rif1p to help controltelomere length and establish telomericsilencing; deletion results in telomereelongation 0.000230.00358 S000004155PUS5YLR165CverifiedPseudouridine synthase, catalyzes only the formation ofpseudouridine (Psi)-2819 in mitochondrial 21SrRNA; not essential for viability 0.000220.00356&radic S000004710YPK2YMR104CverifiedProtein kinase with similarityto serine/threonine proteinkinase Ypk1p; functionally redundant with YPK1at the genetic level; participates in asignaling pathway required for optimal cellwall integrity; homolog of mammalian kinase SGK 0.000220.00356&radic&radic S000004022RAD5YLR032WverifiedSingle-stranded DNA-dependent ATPase, involved inpostreplication repair; contains RING fingerdomain 0.000220.00356&radic&radic S000005996GCR1YPL075WverifiedTranscriptional activator of genes involved in glycolysis;DNA-binding protein that interacts andfunctions with the transcriptional activatorGcr2p 0.000220.00356&radic S000000575YCL073CUncharacterizedProtein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YKR106W 0.000220.00348&radic&radic S000000677SRB8YCR081WverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation; involved in glucoserepression 0.000220.00348&radic&radic S000001937ERJ5YFR041CuncharacterizedType I membrane protein with a J domain is required to preservethe folding capacity of the endoplasmicreticulum; loss of the non-essential ERJ5 geneleads to a constitutively induced unfoldedprotein response 0.000220.00348&radic S000001317YIL055CUncharacterizedHypothetical protein 0.000220.00348&radic&radic S000000829GAL83YER027CverifiedOne of three possible beta-subunits of the Snf1 kinase complex,allows nuclear localization of the Snf1 kinasecomplex in the presence of a nonfermentablecarbon source; contains glycogen-binding domain 0.000220.00341&radic&radic S000002892VPS52YDR484WverifiedComponent of the GARP (Golgi-associated retrograde protein)complex, Vps51p-Vps52p-Vps53p-Vps54p, which isrequired for the recycling of proteins fromendosomes to the late Golgi; involved inlocalization of actin and chitin 0.000220.00341&radic S000003675YUR1YJL139CverifiedMannosyltransferase of the KTR1 family, involved in proteinN-glycosylation; located in the Golgi apparatus 0.000220.00341&radic&radic S000000217YBR013CUncharacterizedHypothetical protein 0.000220.00341&radic&radic S000000002VPS8YAL002WverifiedMembrane-associated hydrophilic protein that interacts with thesmall GTPase, Vps21p, to facilitate solublevacuolar protein localization; required forlocalization and trafficking of the CPY sortingreceptor; contains a RING finger motif 0.000220.00338&radic S000002302CCT4YDL143WverifiedSubunit of the cytosolic chaperonin Cct ring complex, relatedto Tcp1p, required for the assembly of actinand tubulins in vivo 0.000220.00338&radic&radic S000001745SPC34YKR037CverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; also localized tonuclear side of spindle pole body 0.000220.00331&radic&radic S000004995YNL050CUncharacterizedPutative protein of unknown function; YNL050c is not an essential gene 0.000220.00331&radic S000001938YFR042WUncharacterizedPutative protein of unknown function; required for cell viability 0.000220.00328&radic S000002185YDL027CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; YDL027C is not an essential gene 0.000220.00323&radic S000003773YJR012CUncharacterizedPutative protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W 0.000220.00316&radic S000005260PHA2YNL316CverifiedPrephenate dehydratase, catalyzes the conversion of prephanateto phenylpyruvate, which is a step in thephenylalanine biosynthesis pathway 0.000220.00316&radic&radic S000000672YCR076CUncharacterizedPutative protein of unknown function; YCR076C is not an essential gene 0.000220.00316&radic S000000663SED4YCR067CverifiedIntegral endoplasmic reticulum membrane protein, functions as apositive regulator of Sar1p probably throughinhibition of GTPase activation by Sec23p;binds Sec16p, participates in vesicleformation, similar to Sec12p 0.000210.00314&radic S000000111ACH1YBL015WverifiedAcetyl-coA hydrolase, primarily localized to mitochondria;required for acetate utilization and fordiploid pseudohyphal growth 0.000210.00314&radic S000000077YAR029WUncharacterizedMember of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 0.000210.00314&radic S000006359NCA2YPR155CverifiedProtein involved in regulation of mitochondrial expression ofsubunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1ATP synthase; functions with Nca3p 0.000210.0031&radic&radic S000005457WRS1YOL097CverifiedCytoplasmic tryptophanyl-tRNA synthetase, aminoacylatestryptophanyl-tRNA 0.000210.0031&radic&radic S000000084FLO1YAR050WverifiedLectin-like protein involved in flocculation, cell wall proteinthat binds to mannose chains on the surface ofother cells, confers floc-forming ability thatis chymotrypsin sensitive and heat resistant;similar to Flo5p 0.000210.0031&radic&radic S000006384AOS1YPR180WverifiedNuclear protein that acts as a heterodimer with Uba2p toactivate Smt3p (SUMO) before its conjugation toproteins (sumoylation), which may play a rolein protein targeting; essential for viability 0.000210.00307&radic S000001258PHO12YHR215WverifiedOne of three repressible acid phosphatases, a glycoprotein thatis transported to the cell surface by thesecretory pathway; nearly identical to Pho11p;upregulated by phosphate starvation 0.000210.00307&radic&radic S000006141RPL1AYPL220WverifiedN-terminally acetylated protein component of the large (60S)ribosomal subunit, nearly identical to Rpl1Bpand has similarity to E. coli L1 and rat L10aribosomal proteins; rpl1a rpl1b double nullmutation is lethal 0.000210.00307 S000005343FRE4YNR060WverifiedFerric reductase, reduces a specific subset ofsiderophore-bound iron prior to uptake bytransporters; expression induced by low ironlevels 0.000210.00307&radic&radic S000003667YJL131CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria; YJL131C is a non-essential gene 0.000210.00307&radic&radic S000000406CDC47YBR202WverifiedComponent of the hexameric MCM complex, which is important forpriming origins of DNA replication in G1 andbecomes an active ATP-dependent helicase thatpromotes DNA melting and elongation whenactivated by Cdc7p-Dbf4p in S-phase 0.000210.00305&radic&radic S000001261YHR218WUncharacterizedHelicase-like protein encoded within the telomeric Y' element 0.000210.00305&radic&radic S000001051YHR009CUncharacterizedPutative protein of unknown function; not an essential gene 0.000210.00305&radic&radic S000003085YGL117WUncharacterizedPutative protein of unknown function 0.000210.00305&radic&radic S000003212TAD1YGL243WverifiedtRNA-specific adenosine deaminase, deaminates adenosine-37 toinosine in tRNA-Ala 0.000210.00302&radic&radic S000000069BUD14YAR014CverifiedProtein involved in bud-site selection, Bud14p-Glc7p complexfunctions as a cortical regulator of dynein;diploid mutants display a random buddingpattern instead of the wild-type bipolarpattern 0.000210.00302&radic S000001494CCE1YKL011CverifiedMitochondrial cruciform cutting endonuclease, cleaves Hollidayjunctions formed during recombination ofmitochondrial DNA 0.000210.00302&radic&radic S000001333PCI8YIL071CverifiedPossible shared subunit of Cop9 signalosome (CSN) and eIF3,binds eIF3b subunit Prt1p, has possible dualfunctions in transcriptional and translationalcontrol, contains a PCI (Proteasome-COP9signalosome (CSN)-eIF3) domain 0.000210.00302&radic&radic S000006295YPR091CUncharacterizedHypothetical protein 0.000210.00299&radic&radic S000000460RIB5YBR256CverifiedRiboflavin synthase; catalyzes the last step of the riboflavinbiosynthesis pathway 0.000210.00299&radic&radic S000002636PCF11YDR228CverifiedmRNA 3' end processing factor, essential component of cleavageand polyadenylation factor IA (CF IA), involvedin pre-mRNA 3' end processing and intranscription termination; binds C-terminaldomain of largest subunit of RNA pol II(Rpo21p) 0.000210.00298&radic&radic S000000667IMG2YCR071CverifiedMitochondrial ribosomal protein of the small subunit 0.000210.00298&radic&radic S000000456DUT1YBR252WverifieddUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, therebypreventing incorporation of uracil into DNAduring replication; critical for themaintenance of genetic stability 0.000210.00291&radic&radic S000002847LRS4YDR439WverifiedProtein involved in rDNA silencing; positively chargedcoiled-coil protein with limited similarity tomyosin 0.000210.00291&radic S000003723SWE1YJL187CverifiedProtein kinase that regulates the G2/M transition by inhibitionof Cdc28p kinase activity; localizes to thenucleus and to the daughter side of themother-bud neck; homolog of S. pombe Wee1p;potential Cdc28p substrate 0.000210.00291&radic&radic S000005537AUS1YOR011WverifiedTransporter of the ATP-binding cassette family, involved inuptake of sterols and anaerobic growth 0.000210.00291&radic&radic S000004846YMR233WUncharacterizedProtein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; YMR233W is not an essential gene 0.000210.00291&radic&radic&radic S000003706ASG7YJL170CverifiedProtein that regulates signaling from a G protein beta subunitSte4p and its relocalization within the cell;specific to a-cells and induced by alpha-factor 0.00020.00284&radic S000003200YGL231CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum 0.00020.00284&radic&radic S000000089YAR064WUncharacterizedPutative protein of unknown function 0.00020.00271&radic&radic S000003702QCR8YJL166WverifiedSubunit 8 of ubiquinol cytochrome-c reductase complex, which isa component of the mitochondrial inner membraneelectron transport chain; oriented facing theintermembrane space; expression is regulated byAbf1p and Cpf1p 0.00020.00271&radic&radic S000003693FAR1YJL157CverifiedCyclin-dependent kinase inhibitor that mediates cell cyclearrest in response to pheromone; also forms acomplex with Cdc24p, Ste4p, and Ste18p that mayspecify the direction of polarized growthduring mating; potential Cdc28p substrate 0.00020.00271&radic&radic S000000744EAF5YEL018WuncharacterizedEsa1p-associated factor, subunit of the NuA4 acetyltransferasecomplex 0.00020.00268 S000000124YBL028CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis 0.00020.00266&radic&radic S000002211PBP4YDL053CverifiedPbp1p binding protein, interacts strongly with Pab1p-bindingprotein 1 (Pbp1p) in the yeast two-hybridsystem; also interacts with Lsm12p in acopurification assay 0.00020.00263&radic&radic S000001886SMC1YFL008WverifiedSubunit of the multiprotein cohesin complex, essential proteininvolved in chromosome segregation and indouble-strand DNA break repair; SMC chromosomalATPase family member, binds DNA with apreference for DNA with secondary structure 0.000190.00242 S000006177CLN2YPL256CverifiedG1 cyclin involved in regulation of the cell cycle; activatesCdc28p kinase to promote the G1 to S phasetransition; late G1 specific expression dependson transcription factor complexes, MBF(Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) 0.000160.00209 S000001906UBP6YFR010WverifiedUbiquitin-specific protease situated in the base subcomplex ofthe 26S proteasome, releases free ubiquitinfrom branched polyubiquitin chains; deletioncauses hypersensitivity to cycloheximide andother toxic compounds 0.000110.00161 S000003897YJR136CUncharacterizedPutative protein of unknown function; may interact with mitochondrial ribosomal protein Rsm23p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.000110.00158&radic&radic S000004763RIM13YMR154CverifiedCalpain-like protease involved in proteolytic activation ofRim101p in response to alkaline pH; hassimilarity to A. nidulans palB 0.000110.00157 S000028697YMR315W-AUncharacterizedPutative protein of unknown function 0.000110.00157 S000028551YGR240C-AUncharacterizedPutative protein of unknown function; identified by fungal homology and RT-PCR 0.00010.00154 S000001443DJP1YIR004WverifiedCytosolic J-domain-containing protein, required for peroxisomalprotein import and involved in peroxisomeassembly, homologous to E. coli DnaJ 0.00010.00154 S000006191MDL2YPL270WverifiedHalf-type ATP-binding cassette (ABC) transporter of the innermitochondrial membrane 0.00010.00154 S000003801GEF1YJR040WverifiedChloride channel localized to late- or post-Golgi vesicles,involved in iron metabolism; highly homologousto voltage-gated chloride channels invertebrates 0.00010.00152 S000002203FAD1YDL045CverifiedFlavin adenine dinucleotide (FAD) synthetase, performs thesecond step in synthesis of FAD from riboflavin 0.00010.00152 S000004296STT4YLR305CverifiedPhosphatidylinositol-4-kinase that functions in the Pkc1pprotein kinase pathway; required for normalvacuole morphology, cell wall integrity, andactin cytoskeleton organization 0.00010.00152 S000001018YHL026CUncharacterizedPutative protein of unknown function; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History) 0.00010.00152 S000004860FAA4YMR246WverifiedLong chain fatty acyl-CoA synthetase, regulates proteinmodification during growth in the presence ofethanol, functions to incorporate palmitic acidinto phospholipids and neutral lipids 0.00010.00152 S000005069ESBP6YNL125CverifiedProtein with similarity to monocarboxylate permeases, appearsnot to be involved in transport ofmonocarboxylates such as lactate, pyruvate oracetate across the plasma membrane 0.00010.00152 S000002615UME6YDR207CverifiedKey transcriptional regulator of early meiotic genes, bindsURS1 upstream regulatory sequence, couplesmetabolic responses to nutritional cues withinitiation and progression of meiosis, formscomplex with Ime1p, and also with Sin3p-Rpd3p 0.00010.00152 S000003915YJR154WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 0.00010.00152 S000006307PRE2YPR103Wverified20S proteasome beta-type subunit, responsible for thechymotryptic activity of the proteasome 0.00010.00152 S000004901HSH155YMR288WverifiedU2-snRNP associated splicing factor that forms extensiveassociations with the branch site-3' splicesite-3' exon region upon prespliceosomeformation; similarity to the mammalian U2snRNP-associated splicing factor SAP155 0.00010.00152 S000003730CDC6YJL194WverifiedEssential ATP-binding protein required for DNA replication,component of the pre-replicative complex(pre-RC) which requires ORC to associate withchromatin and is in turn required for Mcm2-7pDNA association; homologous to S. pombe Cdc18p 0.00010.00152 S000005837NOP58YOR310CverifiedProtein involved in pre-rRNA processing, 18S rRNA synthesis,and snoRNA synthesis; component of the smallsubunit processome complex, which is requiredfor processing of pre-18S rRNA 0.00010.00152&radic S000001080RRF1YHR038WverifiedMitochondrial ribosome recycling factor, essential formitochondrial protein synthesis and for themaintenance of the respiratory function ofmitochondria 0.00010.00152 S000000950SPT15YER148WverifiedTATA-binding protein, general transcription factor thatinteracts with other factors to form thepreinitiation complex at promoters, essentialfor viability 0.00010.00152 S000003666URA2YJL130CverifiedBifunctional carbamoylphosphate synthetase (CPSase)-aspartatetranscarbamylase (ATCase), catalyzes the firsttwo enzymatic steps in the de novo biosynthesisof pyrimidines; both activities are subject tofeedback inhibition by UTP 0.00010.0015&radic S000006244TIP41YPR040WverifiedProtein that interacts physically and genetically with Tap42p,which regulates protein phosphatase 2A;component of the TOR (target of rapamycin)signaling pathway 0.00010.0015 S000001153UBA4YHR111WverifiedProtein that activates Urm1p before its conjugation to proteins(urmylation); one target is the thioredoxinperoxidase Ahp1p, suggesting a role ofurmylation in the oxidative stress response 0.00010.0015 S000001053DIA4YHR011WverifiedProbable mitochondrial seryl-tRNA synthetase, mutant displaysincreased invasive and pseudohyphal growth 0.00010.0015 S000028553YHR175W-AUncharacterizedPutative protein of unknown function 0.00010.0015 S000004048SHM2YLR058CverifiedCytosolic serine hydroxymethyltransferase, involved inone-carbon metabolism 0.00010.0015 S000004535DAK1YML070WverifiedDihydroxyacetone kinase, required for detoxification ofdihydroxyacetone (DHA); involved in stressadaptation 0.00010.0015 S000005011RPL9BYNL067WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl9Ap and has similarity to E.coli L6 and rat L9 ribosomal proteins 0.00010.0015 S000005126IPI3YNL182CuncharacterizedProtein required for cell viability; computational analysis oflarge-scale protein-protein interaction datasuggests a possible role in assembly of theribosomal large subunit 0.00010.0015 S000001701SRY1YKL218Cverified3-hydroxyaspartate dehydratase, deaminatesL-threo-3-hydroxyaspartate to form oxaloacetateand ammonia; required for survival in thepresence of hydroxyaspartate 0.00010.0015 S000003420BUB1YGR188CverifiedProtein kinase that forms a complex with Mad1p and Bub3p thatis crucial in the checkpoint mechanism requiredto prevent cell cycle progression into anaphasein the presence of spindle damage, associateswith centromere DNA via Skp1p 0.00010.0015 S000005651CAT5YOR125CverifiedMitochondrial inner membrane protein directly involved inubiquinone biosynthesis, essential for severalother metabolic pathways including respirationand gluconeogenic gene activation 0.00010.0015&radic S000005690YOR164CVerifiedProtein of unknown function; interacts with Mdy2p 0.00010.00149 S000003033ALG2YGL065CverifiedPresumed early mannosyltransferase involved in the N-linkedglycosylation pathway; alg2 mutants exhibittemperature-sensitive growth and abnormalaccumulation of the lipid-linkedoligosaccharide Man2GlcNAc2-PP-Dol 0.00010.00149 S000002393GYP7YDL234CverifiedGTPase-activating protein for yeast Rab family membersincluding: Ypt7p (most effective), Ypt1p,Ypt31p, and Ypt32p (in vitro); involved invesicle mediated protein trafficking 0.00010.00149 S000003180VAM7YGL212WverifiedComponent of the vacuole SNARE complex involved in vacuolarmorphogenesis; SNAP-25 homolog; functions witha syntaxin homolog Vam3p in vacuolar proteintrafficking 0.00010.00149 S000003071RPL28YGL103WverifiedRibosomal protein L29 of the large (60S) ribosomal subunit, hassimilarity to E. coli L15 and rat L27aribosomal proteins; may have peptidyltransferase activity; can mutate tocycloheximide resistance 0.00010.00149 S000001002YHL010CUncharacterizedPutative protein of unknown function, contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences 0.00010.00149 S000002705SUR2YDR297WverifiedSphinganine C4-hydroxylase, catalyses the conversion ofsphinganine to phytosphingosine in sphingolipidbiosyntheis 0.00010.00149 S000001595ABF1YKL112WverifiedDNA binding protein with possible chromatin-reorganizingactivity involved in transcriptionalactivation, gene silencing, and DNA replicationand repair 0.00010.00149 S000000635MATALPHA2YCR039CverifiedHomeobox-domain protein that, with Mcm1p, represses a-specificgenes in haploids; acts with A1p to represstranscription of haploid-specific genes indiploids; one of two genes encoded by theMATalpha mating type cassette 0.00010.00149 S000004197HRD3YLR207WverifiedResident protein of the ER membrane that plays a central rolein ER-associated protein degradation (ERAD),forms HRD complex with Hrd1p and ERADdeterminants that engages in lumen to cytosolcommunication and coordination of ERAD events 0.00010.00149 S000003783LSM8YJR022WverifiedLsm (Like Sm) protein; forms heteroheptameric complex (withLsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p)that is part of spliceosomal U6 snRNP and isalso implicated in processing of pre-tRNA,pre-snoRNA, and pre-rRNA 0.00010.00149 S000003330ESP1YGR098CverifiedSeparase with cysteine protease activity (related to caspases)that promotes sister chromatid separation bymediating dissociation of the cohesin Scc1pfrom chromatin; inhibited by Pds1p 0.00010.00149 S000003713RPL17BYJL177WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl17Ap and has similarity to E.coli L22 and rat L17 ribosomal proteins 0.00010.00149 S000002418SNQ2YDR011WverifiedABC transporter protein involved in multidrug resistance andresistance to singlet oxygen species 0.00010.00149 S000000020FUN26YAL022CverifiedNucleoside transporter with broad nucleoside selectivity;localized to intracellular membranes 0.00010.00149 S000006202ERR2YPL281CverifiedProtein of unknown function, has similarity to enolases 0.00010.00149 S000000203YBL107CUncharacterizedHypothetical protein 0.00010.00149&radic S000001337RPN2YIL075CverifiedSubunit of the 26S proteasome, substrate of theN-acetyltransferase Nat1p 0.00010.00148 S000006204YRF1-7YPL283CverifiedHelicase encoded by the Y' element of subtelomeric regions,highly expressed in the mutants lacking thetelomerase component TLC1; potentiallyphosphorylated by Cdc28p 0.00010.00148 S000000458TRS20YBR254CverifiedOne of 10 subunits of the transport protein particle (TRAPP)complex of the cis-Golgi which mediates vesicledocking and fusion; mutations in the humanhomolog cause the spondyloepiphyseal dysplasiatarda (SEDL) disorder 0.00010.00148&radic&radic S000005828YOR302WVerifiedCPA1 uORF , Arginine attenuator peptide, regulates translation of the CPA1 mRNA 0.00010.00148 S000003499FOL2YGR267CverifiedGTP-cyclohydrolase I, catalyzes the first step in the folicacid biosynthetic pathway 0.00010.00148 S000001526PHD1YKL043WverifiedTranscriptional activator that enhances pseudohyphal growth;regulates expression of FLO11, an adhesinrequired for pseudohyphal filament formation;similar to StuA, an A. nidulans developmentalregulator; potential Cdc28p substrate 0.00010.00148&radic&radic S000004199PNP1YLR209CverifiedPurine nucleoside phosphorylase, specifically metabolizesinosine and guanosine nucleosides 0.00010.00148 S000005120YNL176CUncharacterizedHypothetical protein 0.00010.00148 S000002342YDL183CUncharacterizedPutative protein of unknown function; YBR063C is not an essential gene 0.00010.00148 S000005257YNL313CUncharacterizedProtein required for cell viability 0.00010.00148 S000003023OLE1YGL055WverifiedFatty acid desaturase, required for monounsaturated fatty acidsynthesis and for normal distribution ofmitochondria 0.00010.00148 S000001404CCT2YIL142WverifiedSubunit beta of the cytosolic chaperonin Cct ring complex,related to Tcp1p, required for the assembly ofactin and tubulins in vivo 0.00010.00148 S000000463YBR259WUncharacterizedPutative protein of unknown function; YBR259W is not an essential gene 0.00010.00148 S000002349UFD2YDL190CverifiedUbiquitin chain assembly factor (E4) that cooperates with aubiquitin-activating enzyme (E1), aubiquitin-conjugating enzyme (E2), and aubiquitin protein ligase (E3) to conjugateubiquitin to substrates; also functions as an 0.00010.00148 S000001239UTP9YHR196WverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 0.00010.00148&radic S000004265SMD2YLR275WverifiedCore Sm protein Sm D2; part of heteroheptameric complex (withSmb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D2 0.00010.00148 S000005668LSC1YOR142WverifiedAlpha subunit of succinyl-CoA ligase, which is a mitochondrialenzyme of the TCA cycle that catalyzes thenucleotide-dependent conversion of succinyl-CoAto succinate 0.00010.00148 S000002398ADY3YDL239CverifiedProtein required for spore wall formation, thought to mediateassembly of a Don1p-containing structure at theleading edge of the prospore membrane viainteraction with spindle pole body components;potentially phosphorylated by Cdc28p 0.00010.00148 S000005559EXO1YOR033Cverified5'-3' exonuclease and flap-endonuclease involved inrecombination, double-strand break repair andDNA mismatch repair; member of the Rad2pnuclease family, with conserved N and Inuclease domains 9e-050.00148 S000000763RAD23YEL037CverifiedProtein with ubiquitin-like N terminus, recognizes and bindsdamaged DNA (with Rad4p) during nucleotideexcision repair; regulates Rad4p levels,subunit of Nuclear Excision Repair Factor 2(NEF2); homolog of human HR23A and HR23Bproteins 9e-050.00148 S000000252RPS11BYBR048WverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps11Ap and has similarity to E.coli S17 and rat S11 ribosomal proteins 9e-050.00148&radic S000004062YLR072WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene 9e-050.00148 S000003664PBS2YJL128CverifiedMAP kinase kinase that plays a pivotal role in the osmosensingsignal-transduction pathway, activated undersevere osmotic stress 9e-050.00148&radic&radic S000005929CHL1YPL008WverifiedConserved nuclear protein required to establishsister-chromatid pairing during S-phase,probable DNA helicase with similarity to humanBACH1, which associates with tumor suppressorBRCA1; associates with acetyltransferase Ctf7p 9e-050.00148 S000003105SEC27YGL137WverifiedEssential beta'-coat protein of the COPI coatomer, involved inER-to-Golgi and Golgi-to-ER transport; containsWD40 domains that mediate cargo selectiveinteractions; 45% sequence identity tomammalian beta'-COP 9e-050.00148 S000001208PRP8YHR165CverifiedComponent of the U4/U6-U5 snRNP complex, involved in the secondcatalytic step of splicing 9e-050.00148 S000004565ARG81YML099CverifiedZinc-finger transcription factor of the Zn(2)-Cys(6) binuclearcluster domain type, involved in the regulationof arginine-responsive genes; acts with Arg80pand Arg82p 9e-050.00148 S000001373COX5BYIL111WverifiedSubunit Vb of cytochrome c oxidase, which is the terminalmember of the mitochondrial inner membraneelectron transport chain; predominantlyexpressed during anaerobic growth while itsisoform Va (Cox5Ap) is expressed during aerobicgrowth 9e-050.00148 S000005926AEP3YPL005WverifiedPeripheral mitochondrial inner membrane protein, located on thematrix face of the membrane; stabilizes thebicistronic AAP1-ATP6 mRNA encoding subunits 6and 8 of the ATP synthase complex 9e-050.00148 S000000987YER185WUncharacterizedHypothetical protein 9e-050.00148 S000004444SST2YLR452CverifiedGTPase-activating protein for Gpa1p, regulates desensitizationto alpha factor pheromone; also required toprevent receptor-independent signaling of themating pathway; member of the RGS (regulator ofG-protein signaling) family 9e-050.00148 S000003405RBG2YGR173WuncharacterizedProtein with similarity to mammalian developmentally regulatedGTP-binding protein 9e-050.00148 S000005304YNR021WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene 9e-050.00146 S000006398OPT2YPR194CverifiedOligopeptide transporter; member of the OPT family, withpotential orthologs in S. pombe and C. albicans 9e-050.00146 S000006337SPN1YPR133CverifiedProtein that interacts with Spt6p and copurifies with Spt5p andRNA polymerase II, probable transcriptionalelongation factor; metazoan homologs contain anacidic N terminus; mutations in the gene conferan Spt- phenotype 9e-050.00146 S000001183RPL42BYHR141CverifiedProtein component of the large (60S) ribosomal subunit,identical to Rpl42Ap and has similarity to ratL44; required for propagation of the killertoxin-encoding M1 double-stranded RNA satelliteof the L-A double-stranded RNA virus 9e-050.00146 S000001304PKP1YIL042CverifiedMitochondrial kinase, phosphorylates pyruvate dehydrogenasealpha subunit Pda1p 9e-050.00146 S000005861MRS2YOR334WverifiedMitochondrial inner membrane Mg(2+) channel, required formaintenance of intramitochondrial Mg(2+)concentrations at the correct level to supportsplicing of group II introns 9e-050.00146 S000004724YMR118CUncharacterizedProtein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene 9e-050.00146 S000005969CAM1YPL048WverifiedHomolog of translational cofactor elongation factor-1 gamma,participates in the regulation of GTP-bindingprotein EF-1 alpha, may play a redundant rolein the regulation of protein synthesis oranother GTP-dependent process 9e-050.00146 S000006194SAM4YPL273WverifiedS-adenosylmethionine-homocysteine methyltransferase, functionsalong with Mht1p in the conversion ofS-adenosylmethionine (AdoMet) to methionine tocontrol the methionine/AdoMet ratio 9e-050.00146 S000000383FZO1YBR179CverifiedMitochondrial integral membrane protein involved inmitochondrial fusion and maintenance of themitochondrial genome; contains N-terminalGTPase domain 9e-050.00146 S000028510SUS1YBR111W-AverifiedProtein involved in mRNA export coupled transcriptionactivation; component of the SAGA histoneacetylase complex 9e-050.00146 S000000276HSP26YBR072WverifiedSmall heat shock protein with chaperone activity that isregulated by a heat induced transition from aninactive oligomeric (24-mer) complex to anactive dimer; induced by heat, upon entry intostationary phase, and during sporulation 9e-050.00146 S000005755WTM2YOR229WverifiedTranscriptional repressor involved in regulation of meiosis andsilencing; contains WD repeats 9e-050.00146 S000002448RSM10YDR041WverifiedMitochondrial ribosomal protein of the small subunit, hassimilarity to E. coli S10 ribosomal protein;essential for viability, unlike most othermitoribosomal proteins 9e-050.00146 S000002162ATP16YDL004WverifiedDelta subunit of the central stalk of mitochondrial F1F0 ATPsynthase, which is a large, evolutionarilyconserved enzyme complex required for ATPsynthesis 9e-050.00146 S000001396FLX1YIL134WverifiedProtein required for transport of flavin adenine dinucleotide(FAD), a synthesis product of riboflavin,across the mitochondrial membrane 9e-050.00146 S000005742RUD3YOR216CverifiedGolgi matrix protein involved in the structural organization ofthe cis-Golgi; interacts genetically with COG3and USO1 9e-050.00146 S000004298CDA1YLR307WverifiedChitin deacetylase, together with Cda2p involved in thebiosynthesis ascospore wall component,chitosan; required for proper rigidity of theascospore wall 9e-050.00146 S000003007YGL039WVerifiedOxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol) 9e-050.00146 S000028640YGR204C-AUncharacterizedPutative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 9e-050.00146 S000004289YHC1YLR298CverifiedComponent of the U1 snRNP complex required for pre-mRNAsplicing; putative ortholog of human U1Cprotein, which is involved in formation of acomplex between U1 snRNP and the pre-mRNA 5'splice site 9e-050.00146 S000001878MDJ1YFL016CverifiedProtein involved in folding of mitochondrially synthesizedproteins in the mitochondrial matrix; localizesto the mitochondrial inner membrane; member ofthe DnaJ family of molecular chaperones 9e-050.00146 S000004395SFP1YLR403WverifiedTranscription factor that controls expression of many ribosomebiogenesis genes in response to nutrients andstress, regulates G2/M transitions duringmitotic cell cycle and DNA-damage response,involved in cell size modulation 9e-050.00146 S000003942KNS1YLL019CverifiedNonessential putative protein kinase of unknown cellular role;member of the LAMMER family of protein kinases,which are serine/threonine kinases also capableof phosphorylating tyrosine residues 9e-050.00146 S000004821ERG12YMR208WverifiedMevalonate kinase, acts in the biosynthesis of isoprenoids andsterols, including ergosterol, from mevalonate 9e-050.00146 S000003969RNP1YLL046CverifiedRibonucleoprotein that contains two RNA recognition motifs(RRM) 9e-050.00146 S000005921PAU21YOR394WuncharacterizedHypothetical protein 9e-050.00146 S000003449CCH1YGR217WverifiedVoltage-gated high-affinity calcium channel involved in calciuminflux in response to some environmentalstresses as well as exposure to matingpheromones; interacts and co-localizes withMid1p, suggesting Cch1p and Mid1p functiontogether 9e-050.00146 S000004525OGG1YML060WverifiedMitochondrial glycosylase/lyase that specifically excises7,8-dihydro-8-oxoguanine residues locatedopposite cytosine or thymine residues in DNA,repairs oxidative damage to mitochondrial DNA 9e-050.00146 S000000532FUS1YCL027WverifiedMembrane protein localized to the shmoo tip, required for cellfusion; expression regulated by matingpheromone; proposed to coordinate signaling,fusion, and polarization events required forfusion; potential Cdc28p substrate 9e-050.00146 S000003968RPL8BYLL045CverifiedRibosomal protein L4 of the large (60S) ribosomal subunit,nearly identical to Rpl8Ap and has similarityto rat L7a ribosomal protein; mutation resultsin decreased amounts of free 60S subunits 9e-050.00146 S000000208GPI18YBR004CverifiedFunctional ortholog of human PIG-V, which is amannosyltransferase that transfers the secondmannose in glycosylphosphatidylinositolbiosynthesis; the authentic, non-tagged proteinwas localized to mitochondria 9e-050.00146&radic S000004674MOT3YMR070WverifiedNuclear transcription factor with two Cys2-His2 zinc fingers;involved in repression of a subset of hypoxicgenes by Rox1p, repression of several DAN/TIRgenes during aerobic growth, and repression ofergosterol biosynthetic genes 9e-050.00146 S000005850PRO2YOR323CverifiedGamma-glutamyl phosphate reductase, catalyzes the second stepin proline biosynthesis 9e-050.00146 S000004775PAH1YMR165CverifiedMg2+-dependent phosphatidate (PA) phosphatase,catalyzes the dephosphorylation of PA to yielddiacylglycerol and Pi, responsiblefor de novo lipid synthesis; homologous tomammalian lipin 1 9e-050.00146 S000001101FYV4YHR059WverifiedProtein of unknown function, required for survival uponexposure to K1 killer toxin 9e-050.00146 S000001834SNO3YFL060CverifiedProtein of unknown function, nearly identical to Sno2p;expression is induced before the diauxic shiftand also in the absence of thiamin 9e-050.00146 S000000160PRX1YBL064CverifiedMitochondrial peroxiredoxin (1-Cys Prx) with thioredoxinperoxidase activity, has a role in reduction ofhydroperoxides; induced during respiratorygrowth and under conditions of oxidative stress 9e-050.00146 S000000842GLN3YER040WverifiedTranscriptional activator of genes regulated by nitrogencatabolite repression (NCR), localization andactivity regulated by quality of nitrogensource 9e-050.00146 S000003222HXK2YGL253WverifiedHexokinase isoenzyme 2 that catalyzes phosphorylation ofglucose in the cytosol; predominant hexokinaseduring growth on glucose; functions in thenucleus to repress expression of HXK1 and GLK1and to induce expression of its own gene 9e-050.00146 S000003810UTR1YJR049CverifiedATP-NADH kinase; phosphorylates both NAD and NADH; active as ahexamer; enhances the activity of ferricreductase (Fre1p) 9e-050.00146 S000005636TFC7YOR110WverifiedOne of six subunits of the RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part of theTauA globular domain of TFIIIC that binds DNAat the BoxA promoter sites of tRNA and similargenes 9e-050.00146 S000005940VTC3YPL019CverifiedVacuolar membrane protein involved in vacuolar polyphosphateaccumulation; functions as a regulator ofvacuolar H+-ATPase activity and vacuolartransporter chaperones; involved innon-autophagic vacuolar fusion 9e-050.00146 S000005884SNX3YOR357CverifiedSorting nexin required to maintain late-Golgi resident enzymesin their proper location by recycling moleculesfrom the prevacuolar compartment; contains a PXdomain and sequence similarity to human Snx3p 9e-050.00146 S000005618ECM3YOR092WverifiedNon-essential protein of unknown function 9e-050.00146 S000002354SEC31YDL195WverifiedEssential phosphoprotein component (p150) of the COPII coat ofsecretory pathway vesicles, in complex withSec13p; required for ER-derived transportvesicle formation 9e-050.00146 S000000055ECM1YAL059WverifiedProtein of unknown function, localized in the nucleoplasm andthe nucleolus, genetically interacts with MTR2in 60S ribosomal protein subunit export 9e-050.00146 S000001955AUA1YFL010W-AverifiedProtein required for the negative regulation by ammonia ofGap1p, which is a general amino acid permease 9e-050.00146 S000004254RPS28BYLR264WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps28Ap and has similarity to ratS28 ribosomal protein 9e-050.00146 S000000961BUR6YER159CverifiedProtein that forms a heterodimeric histone-fold NC2 generaltranscription regulator complex with Ydr1p thatbinds to TBP and represses RNA pol IItranscription during assembly of thepreinitiation complex, homologous to humanNC2alpha 9e-050.00146 S000001025RPL8AYHL033CverifiedRibosomal protein L4 of the large (60S) ribosomal subunit,nearly identical to Rpl8Bp and has similarityto rat L7a ribosomal protein; mutation resultsin decreased amounts of free 60S subunits 9e-050.00146 S000003353MEP1YGR121CverifiedAmmonium permease; belongs to a ubiquitous family ofcytoplasmic membrane proteins that transportonly ammonium (NH4+); expression is under thenitrogen catabolite repression regulation 9e-050.00146 S000003745CBP1YJL209WverifiedMitochondrial protein that interacts with the 5'-untranslatedregion of the COB mRNA and has a role in itsstability and translation; found in a complexat the inner membrane along with Pet309p 9e-050.00146 S000004103HOG1YLR113WverifiedMitogen-activated protein kinase involved in osmoregulation viathree independent osmosensors; mediates therecruitment and activation of RNA Pol II atHot1p-dependent promoters; localizationregulated by Ptp2p and Ptp3p 9e-050.00146 S000004613HXT2YMR011WverifiedHigh-affinity glucose transporter of the major facilitatorsuperfamily, expression is induced by lowlevels of glucose and repressed by high levelsof glucose 9e-050.00146 S000000880YER078CUncharacterizedMetallopeptidase, localized to the mitochondrial matrix 9e-050.00146 S000003260MSP1YGR028WverifiedMitochondrial protein involved in sorting of proteins in themitochondria; putative membrane-spanning ATPase 9e-050.00146 S000007605YDR379C-AUncharacterizedHypothetical protein identified by homology. See FEBS Letters [2000] 487:31-36. 9e-050.00146 S000001817YAL065CUncharacterizedHypothetical protein 9e-050.00146&radic S000003598LAS21YJL062WverifiedIntegral plasma membrane protein involved in the synthesis ofthe glycosylphosphatidylinositol (GPI) corestructure; mutations affect cell wall integrity 9e-050.00145 S000004712YKU80YMR106CverifiedSubunit of the telomeric Ku complex (Yku70p-Yku80p), involvedin telomere length maintenance, structure andtelomere position effect; relocates to sites ofdouble-strand cleavage to promote nonhomologousend joining during DSB repair 9e-050.00145 S000001391TAO3YIL129CverifiedProtein involved in cell morphogenesis and proliferation,associated with protein kinase Cbk1p; mutantsactivate OCH1 transcription 9e-050.00145 S000001761YSR3YKR053CverifiedDihydrosphingosine 1-phosphate phosphatase, membrane proteininvolved in sphingolipid metabolism; hassimilarity to Lcb3p 9e-050.00145&radic S000005728HIS3YOR202WverifiedImidazoleglycerol-phosphate dehydratase, catalyzes the sixthstep in histidine biosynthesis; mutations causehistidine auxotrophy and sensitivity to Cu, Co,and Ni salts; transcription is regulated bygeneral amino acid control via Gcn4p 9e-050.00145 S000006129RKM1YPL208WverifiedSET-domain lysine-N-methyltransferase, catalyzes the formationof dimethyllysine residues on the largeribsomal subunit protein L23a (RPL23A andRPL23B) 9e-050.00145 S000003892MNS1YJR131WverifiedAlpha-1,2-mannosidase involved in ER quality control; catalyzesthe removal of one mannose residue fromMan9GlcNAc to produce a single isomer ofMan8GlcNAc in N-linked oligosaccharidebiosynthesis; integral to ER membrane 9e-050.00145 S000002414TRP1YDR007WverifiedPhosphoribosylanthranilate isomerase that catalyzes the thirdstep in tryptophan biosynthesis; in 2004, thesequence of TRP1 from strain S228C was updatedby changing the previously annotated internalSTOP (TAA) to serine (TCA) 9e-050.00145 S000006083YPL162CUncharacterizedHypothetical protein 9e-050.00145 S000004644YMR041CUncharacterizedPutative protein of unknown function with similarity to aldo/keto reductases; YMR041C is not an essential gene 9e-050.00145 S000004546YML081WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YML081w is not an essential gene 9e-050.00145&radic S000003157RPS26AYGL189CverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps26Bp and has similarity to ratS26 ribosomal protein 9e-050.00145 S000000735GCN4YEL009CverifiedTranscriptional activator of amino acid biosynthetic genes inresponse to amino acid starvation; expressionis tightly regulated at both thetranscriptional and translational levels 9e-050.00145 S000004490TSA1YML028WverifiedUbiquitous housekeeping thioredoxin peroxidase, reducesreactive oxygen, nitrogen and sulfur speciesusing thioredoxin as hydrogen donor; mediatesredox regulation of the nuclear localization ofYap1p; deletion results in mutator phenotype 9e-050.00145 S000000604ADP1YCR011CverifiedPutative ATP-dependent permease of the ABC transporter familyof proteins 9e-050.00145 S000005309SEC12YNR026CverifiedGuanine nucleotide exchange factor (GEF); glycosylated integralmembrane protein of the endoplasmic reticulum,important for the initiation of transportvesicle budding from the endoplasmic reticulumthrough activation of the GTPase Sar1p 9e-050.00145 S000002170YDL012CUncharacterizedPlasma membrane protein of unknown function; YDL012C is not an essential gene 9e-050.00145 S000000760HYP2YEL034WverifiedTranslation initiation factor eIF-5A, promotes formation of thefirst peptide bond; similar to and functionallyredundant with Anb1p; possible role intranslation elongation; undergoes an essentialhypusination modification 9e-050.00145 S000000642IMG1YCR046CverifiedMitochondrial ribosomal protein of the large subunit, requiredfor respiration and for maintenance of themitochondrial genome 9e-050.00145 S000004524NTE1YML059CverifiedSerine esterase that deacylates exogenous lysophospholipids,homolog of human neuropathy target esterase(NTE); mammalian NTE1 deacylatesphosphatidylcholine to glycerophosphocholine 9e-050.00145 S000004552YML087CUncharacterizedHypothetical protein 9e-050.00145 S000002319DHH1YDL160CverifiedCytoplasmic DExD/H-box helicase, stimulates mRNA decapping,coordinates distinct steps in mRNA function anddecay, interacts with both the decapping anddeadenylase complexes, may have a role in mRNAexport and translation 9e-050.00145 S000005189CWC25YNL245CverifiedComponent of a complex containing Cef1p, involved in pre-mRNAsplicing; has similarity to S. pombe Cwf25p 9e-050.00145 S000003384RSR1YGR152CverifiedGTP-binding protein of the ras superfamily required for budsite selection, morphological changes inresponse to mating pheromone, and efficientcell fusion; localized to the plasma membrane;significantly similar to mammalian Rap GTPases 9e-050.00145 S000028508VMA9YCL005W-AverifiedVacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex;essential for vacuolar acidification; interactswith the V-ATPase assembly factor Vma21p in theER; involved in V0 biogenesis 9e-050.00145 S000003992NOC3YLR002CverifiedProtein that forms a nuclear complex with Noc2p that binds to66S ribosomal precursors to mediate theirintranuclear transport; also binds to chromatinto promote the association of DNA replicationfactors and replication initiation 9e-050.00145&radic S000005977YPL056CUncharacterizedHypothetical protein 9e-050.00145 S000003468SPG1YGR236CverifiedProtein required for survival at high temperature duringstationary phase; not required for growth onnonfermentable carbon sources; the authentic,non-tagged protein is detected in highlypurified mitochondria in high-throughputstudies 9e-050.00145 S000005666SFL1YOR140WverifiedTranscription repressor involved in regulation offlocculation-related genes, inhibitstranscription by recruiting general corepressorCyc8p-Tup1p to different promoters; negativelyregulated by cAMP-dependent protein kinase Asubunit Tpk2p 9e-050.00145 S000005698YRM1YOR172WverifiedZn2-Cys6 zinc-finger transcription factor that activates genesinvolved in multidrug resistance; paralog ofYrr1p, acting on an overlapping set of targetgenes 9e-050.00145 S000002886SNM1YDR478WverifiedSubunit of RNase MRP, which cleaves pre-rRNA; not sharedbetween Rnase MRP and nuclear Rnase P, incontrast to all other Rnase MRP proteinsubunits; binds to the NME1 RNA subunit ofRnase MRP 9e-050.00145 S000002626SPR28YDR218CverifiedSporulation-specific homolog of the yeast CDC3/10/11/12 familyof bud neck microfilament genes; meiotic septinexpressed at high levels during meioticdivisions and ascospore formation 9e-050.00145 S000000767YEF1YEL041WverifiedATP-NADH kinase; phosophorylates both NAD and NADH;homooctameric structure consisting of 60-kDasubunits; sequence similarity to Utr1p andPos5p; overexpression complements certain pos5phenotypes 9e-050.00145 S000000041PTA1YAL043CverifiedSubunit of holo-CPF, a multiprotein complex and functionalhomolog of mammalian CPSF, required for thecleavage and polyadenylation of mRNA and snoRNA3' ends; involved in pre-tRNA processing; bindsto the phosphorylated CTD of RNAPII 9e-050.00145 S000000758MCM3YEL032WverifiedProtein involved in DNA replication; component of the Mcm2-7hexameric complex that binds chromatin as apart of the pre-replicative complex 9e-050.00145 S000005501PPM2YOL141WverifiedPutative carboxyl methyl transferase, has similarity to Ppm1pbut biochemical activity not yet demonstrated;the authentic, non-tagged protein is detectedin highly purified mitochondria inhigh-throughput studies 9e-050.00145&radic S000002230YET3YDL072CverifiedProtein of unknown function; YET3 null mutant decreases thelevel of secreted invertase; homolog of humanBAP31 protein 9e-050.00145 S000002857UTP6YDR449CverifiedNucleolar protein, component of the small subunit (SSU)processome containing the U3 snoRNA that isinvolved in processing of pre-18S rRNA 9e-050.00145&radic S000003457AMA1YGR225WverifiedActivator of meiotic anaphase promoting complex (APC/C); Cdc20pfamily member; required for initiation of sporewall assembly; required for Clb1p degradationduring meiosis 9e-050.00145 S000002997CGR1YGL029WverifiedProtein involved in nucleolar integrity and processing of thepre-rRNA for the 60S ribosome subunit;transcript is induced in response to cytotoxicstress but not genotoxic stress 9e-050.00145 S000003616SCP160YJL080CverifiedEssential RNA-binding G protein effector of mating responsepathway, predominantly associated with nuclearenvelope and ER, interacts in mRNA-dependentmanner with translating ribosomes via multipleKH domains, similar to vertebrate vigilins 9e-050.00145 S000003473YAP1802YGR241CverifiedProtein involved in clathrin cage assembly; binds Pan1p andclathrin; homologous to Yap1801p, member of theAP180 protein family 9e-050.00145 S000000405DER1YBR201WverifiedEndoplasmic reticulum membrane protein, required forER-associated protein degradation of misfoldedor unassembled proteins; N- and C- terminiprotrude into the cytoplasm, has similarity toDfm1p 9e-050.00145 S000005452YOL092WUncharacterizedHypothetical protein 9e-050.00145 S000000664ATG15YCR068WverifiedLipase, required for intravacuolar lysis of autophagic bodies;located in the endoplasmic reticulum membraneand targeted to intravacuolar vesicles duringautophagy via the multivesicular body (MVB)pathway 9e-050.00144&radic S000004026YLR036CUncharacterizedPutative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein 9e-050.00144 S000005491YOL131WUncharacterizedPutative protein of unknown function 9e-050.00144 S000003447RSM27YGR215WverifiedMitochondrial ribosomal protein of the small subunit 9e-050.00144 S000001728VPS51YKR020WverifiedComponent of the GARP (Golgi-associated retrograde protein)complex, Vps51p-Vps52p-Vps53p-Vps54p, which isrequired for the recycling of proteins fromendosomes to the late Golgi; links the(VFT/GARP) complex to the SNARE Tlg1p 9e-050.00144 S000004278RPS30AYLR287C-AverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps30Bp and has similarity to ratS30 ribosomal protein 9e-050.00144 S000005168SQS1YNL224CverifiedProtein of unknown function; overexpression antagonizes thesuppression of splicing defects by spp382mutants; green fluorescent protein (GFP)-fusionprotein localizes to both the cytoplasm and thenucleus 9e-050.00144 S000005677RPB2YOR151CverifiedRNA polymerase II second largest subunit B150, part of centralcore; similar to bacterial beta subunit 9e-050.00144 S000002429CIS1YDR022CverifiedProtein of unknown function that may be involved in microtubuleorganization; high-copy suppressor of CIK1deletion 9e-050.00144 S000004131RRN5YLR141WverifiedProtein involved in transcription of rDNA by RNA polymerase I;transcription factor, member of UAF (upstreamactivation factor) family along with Rrn9p andRrn10p 9e-050.00144&radic&radic S000003633PHS1YJL097WuncharacterizedProtein of unknown function; homolog of mammalian PTPLA;involved in sphingolipid biosynthesis, proteintrafficking; required for cell viability 9e-050.00144 S000005183LAP3YNL239WverifiedAminopeptidase of cysteine protease family, has a DNA bindingactivity and acts as bleomycin hydrolase invitro; transcription is regulated by galactosevia Gal4p 9e-050.00144 S000002479IPT1YDR072CverifiedInositolphosphotransferase 1, involved in synthesis ofmannose-(inositol-P)2-ceramide (M(IP)2C), whichis the most abundant sphingolipid in cells,mutation confers resistance to the antifungalssyringomycin E and DmAMP1 in some growth media 9e-050.00144 S000004268YLR278CUncharacterizedZinc-cluster protein; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; YLR278C is not an essential gene 9e-050.00144 S000001832COS4YFL062WverifiedProtein of unknown function, member of the DUP380 subfamily ofconserved, often subtelomerically-encodedproteins 9e-050.00144 S000000294YBR090CUncharacterizedHypothetical protein 9e-050.00144 S000001687EAP1YKL204WverifiedeIF4E-associated protein, binds eIF4E and inhibitscap-dependent translation, also functionsindependently of eIF4E to maintain geneticstability; plays a role in cell growth,implicated in the TOR signaling cascade 9e-050.00144 S000001197RTT107YHR154WverifiedProtein implicated in Mms22-dependent DNA repair during Sphase, DNA damage induces phosphorylation byMec1p at one or more SQ/TQ motifs; interactswith Mms22p and Slx4p; has four BRCT domains;has a role in regulation of Ty1 transposition 9e-050.00144 S000006020FMP14YPL099CuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 9e-050.00144 S000003410PBP1YGR178CverifiedProtein interacting with poly(A)-binding protein Pab1p; likelyinvolved in controlling the extent of mRNApolyadenylation; forms a complex with Mkt1pthat may regulate HO translation; interactswith Lsm12p in a copurification assay 9e-050.00144 S000002888DIG2YDR480WverifiedRegulatory protein of unknown function, pheromone-inducible,involved in the regulation of mating-specificgenes and the invasive growth pathway, requiredfor MAP-kinase imposed repression, inhibitspheromone-responsive transcription 9e-050.00144 S000001647PIR1YKL164CverifiedO-glycosylated protein required for cell wall stability;attached to the cell wall via beta-1,3-glucan;mediates mitochondrial translocation of Apn1p;expression regulated by the cell integritypathway and by Swi5p during the cell cycle 9e-050.00144 S000001579CWP1YKL096WverifiedCell wall mannoprotein, linked to a beta-1,3- andbeta-1,6-glucan heteropolymer through aphosphodiester bond; involved in cell wallorganization 9e-050.00144 S000002234RXT3YDL076CuncharacterizedProtein of unknown function, may be involved in chromatinsilencing 9e-050.00144 S000004545DUS1YML080WverifiedDihydrouridine synthase, member of a widespread family ofconserved proteins including Smm1p, Dus3p, andDus4p; modifies pre-tRNA(Phe) at U17 9e-050.00144 S000004182HCR1YLR192CverifiedDual function protein involved in translation initiation as asubstoichiometric component of eukaryotictranslation initiation factor 3 (eIF3) andrequired for processing of 20S pre-rRNA; bindsto eIF3 subunits Rpg1p and Prt1p and 18S rRNA 9e-050.00144 S000005389YOL029CUncharacterizedHypothetical protein 9e-050.00144 S000003266RPL26BYGR034WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl26Ap and has similarity to E.coli L24 and rat L26 ribosomal proteins; bindsto 5.8S rRNA 9e-050.00144 S000003511SCW4YGR279CverifiedCell wall protein with similarity to glucanases; scw4 scw10double mutants exhibit defects in mating 9e-050.00144 S000001267EPS1YIL005WverifiedPdi1p (protein disulfide isomerase)-related protein involved inendoplasmic reticulum retention of resident ERproteins 9e-050.00144 S000005616PTC5YOR090CverifiedMitochondrially localized type 2C protein phosphatase involvedin regulation of pyruvate dehydrogenaseactivity; contains Mg2+/Mn2+-dependent caseinphosphatase activity in vitro 9e-050.00144 S000000478CHK1YBR274WverifiedDNA damage checkpoint effector kinase, mediates mitotic cellcycle arrest via phosphorylation of Pds1p;phosphorylated by checkpoint signal transducerkinase Mec1p; homolog of S. pombe and mammalianChk1 checkpoint kinase 9e-050.00144 S000003019MST27YGL051WverifiedPutative integral membrane protein, involved in vesicleformation; forms complex with Mst28p; member ofDUP240 gene family; binds COPI and COPIIvesicles 9e-050.00144 S000003916AAD10YJR155WverifiedPutative aryl-alcohol dehydrogenase with similarity to P.chrysosporium aryl-alcohol dehydrogenase;mutational analysis has not yet revealed aphysiological role 9e-050.00144 S000000549MGR1YCL044CverifiedSubunit, with Yme1p, of the mitochondrial inner membrane i-AAAprotease complex, which is responsible fordegradation of unfolded or misfoldedmitochondrial gene products; required forgrowth of cells lacking the mitochondrialgenome 9e-050.00144 S000002771ESC2YDR363WverifiedProtein involved in mating-type locus silencing, interacts withSir2p; probably functions to recruit orstabilize Sir proteins 9e-050.00144 S000028532YBR072C-AUncharacterizedIdentified by fungal homology and RT-PCR 9e-050.00144 S000005505CTR9YOL145CverifiedComponent of the Paf1p complex, which is a large complex thatbinds to and modulates the activity of RNApolymerase II and is required for expression ofa subset of genes, including cyclin genes;contains TPR repeats 9e-050.00144 S000002930SPS2YDR522CverifiedProtein expressed during sporulation, redundant with Sps22p fororganization of the beta-glucan layer of thespore wall; S. pombe ortholog is a spore wallcomponent 9e-050.00144 S000005338HOL1YNR055CverifiedPutative ion transporter similar to the major facilitatorsuperfamily of transporters; mutations inmembrane-spanning domains permit nonselectivecation uptake 9e-050.00144 S000004244NDL1YLR254Cuncharacterizedhomolog of nuclear distribution factor NudE, NUDEL 9e-050.00143 S000004596RSC9YML127WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; DNA-binding protein involved inthe synthesis of rRNA and in transcriptionalrepression and activation of genes regulated bythe Target of Rapamycin (TOR) pathway 9e-050.00143 S000002740IRC3YDR332WuncharacterizedHypothetical protein; null mutant displays increased levels ofspontaneous Rad52 foci 9e-050.00143&radic&radic S000004845FUS2YMR232WverifiedCytoplasmic protein localized to the shmoo tip; required forthe alignment of parental nuclei before nuclearfusion during mating 9e-050.00143 S000002173TSC13YDL015CverifiedEnoyl reductase that catalyzes the last step in each cycle ofvery long chain fatty acid elongation,localizes to the ER, highly enriched in astructure marking nuclear-vacuolar junctions,coimmunoprecipitates with elongases Fen1p andSur4p 9e-050.00143 S000002279YDL121CUncharacterizedHypothetical protein 9e-050.00143 S000005913PHR1YOR386WverifiedDNA photolyase involved in photoreactivation, repairspyrimidine dimers in the presence of visiblelight; induced by DNA damage; regulated bytranscriptional repressor Rph1p 9e-050.00143 S000002999RPL24AYGL031CverifiedRibosomal protein L30 of the large (60S) ribosomal subunit,nearly identical to Rpl24Bp and has similarityto rat L24 ribosomal protein; not essential fortranslation but may be required for normaltranslation rate 9e-050.00143 S000003432ELP2YGR200CverifiedSubunit of Elongator complex, which is required formodification of wobble nucleosides in tRNA;target of Kluyveromyces lactis zymocin 9e-050.00143 S000002680GLO2YDR272WverifiedCytoplasmic glyoxalase II, catalyzes the hydrolysis ofS-D-lactoylglutathione into glutathione andD-lactate 9e-050.00143 S000004440RPL6BYLR448WverifiedProtein component of the large (60S) ribosomal subunit, hassimilarity to Rpl6Bp and to rat L6 ribosomalprotein; binds to 5.8S rRNA 9e-050.00143 S000005957PMA2YPL036WverifiedPlasma membrane H+-ATPase, isoform of Pma1p, involved inpumping protons out of the cell; regulator ofcytoplasmic pH and plasma membrane potential 9e-050.00143 S000005072TEP1YNL128WverifiedHomolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that haslipid phosphatase activity and is linked to thephosphatidylinositol signaling pathway; plays arole in normal sporulation 9e-050.00143&radic S000000387YPC1YBR183WverifiedAlkaline ceramidase that also has reverse (CoA-independent)ceramide synthase activity, catalyzes bothbreakdown and synthesis of phytoceramide;overexpression confers fumonisin B1 resistance 9e-050.00143 S000006285GRS2YPR081CverifiedProtein with sequence similarity to Grs1p, which is aglycyl-tRNA synthetase; cannot substitute forGrs1p; possible pseudogene that is expressed atvery low levels 9e-050.00143 S000002463YDR056CUncharacterizedHypothetical protein 9e-050.00143 S000001114ERG7YHR072WverifiedLanosterol synthase, an essential enzyme that catalyzes thecyclization of squalene 2,3-epoxide, a step inergosterol biosynthesis 9e-050.00143 S000001572MIF2YKL089WverifiedKinetochore protein with homology to human CENP-C, required forstructural integrity of the spindle duringanaphase spindle elongation, interacts withhistones H2A, H2B, and H4, phosphorylated byIpl1p 9e-050.00143 S000000986YER184CUncharacterizedHypothetical protein 9e-050.00143 S000004249HSP60YLR259CverifiedTetradecameric mitochondrial chaperonin required forATP-dependent folding of precursor polypeptidesand complex assembly; prevents aggregation andmediates protein refolding after heat shock;role in mtDNA transmission; similarity to groEL 9e-050.00143 S000028574YMR030W-AUncharacterizedPutative protein of unknown function 9e-050.00143 S000001306AGE2YIL044CverifiedADP-ribosylation factor (ARF) GTPase activating protein (GAP)effector, involved in Trans-Golgi-Network (TGN)transport; contains C2C2H2 cysteine/histidinemotif 9e-050.00143 S000003177MIG2YGL209WverifiedProtein containing zinc fingers, involved in repression, alongwith Mig1p, of SUC2 (invertase) expression byhigh levels of glucose; binds to Mig1p-bindingsites in SUC2 promoter 9e-050.00143 S000028566YLR159C-AUncharacterizedPutative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-5 9e-050.00143 S000000965YER163CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 9e-050.00143 S000005093PGA2YNL149CuncharacterizedEssential protein required for maturation of Gas1p and Pho8p;involved in protein trafficking; GFP-fusionprotein localizes to the ER and YFP-fusionprotein to the nuclear envelope-ER network;null mutants have a cell separation defect 9e-050.00143 S000005797FSF1YOR271CuncharacterizedPutative protein, predicted by computational methods to be analpha-isopropylmalate carrier; the authentic,non-tagged protein is detected in highlypurified mitochondria in high-throughputstudies 9e-050.00143 S000003372CBF2YGR140WverifiedEssential kinetochore protein, component of the CBF3multisubunit complex that binds to the CDEIIIregion of the centromere; Cbf2p also binds tothe CDEII region possibly forming a differentmultimeric complex, ubiquitinated in vivo 9e-050.00143 S000005284CIT1YNR001CverifiedCitrate synthase, catalyzes the condensation of acetyl coenzymeA and oxaloacetate to form citrate; therate-limiting enzyme of the TCA cycle; nuclearencoded mitochondrial protein 9e-050.00143 S000002288RPP1BYDL130WverifiedRibosomal protein P1 beta, component of the ribosomal stalk,which is involved in interaction oftranslational elongation factors with ribosome;accumulation is regulated by phosphorylationand interaction with the P2 stalk component 9e-050.00143 S000000947FTR1YER145CverifiedHigh affinity iron permease involved in the transport of ironacross the plasma membrane; forms complex withFet3p; expression is regulated by iron 9e-050.00143 S000006059SPP1YPL138CverifiedSubunit of COMPASS (Set1C), a complex which methylates histoneH3 on lysine 4 and is required in telomerictranscriptional silencing; PHD finger domainprotein similar to human CGBP, an unmethylatedCpG binding protein 9e-050.00143 S000004940YMR321CUncharacterizedHypothetical protein 9e-050.00143 S000004400YLR408CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene 9e-050.00143 S000000834FIR1YER032WverifiedProtein involved in 3' mRNA processing, interacts with Ref2p;potential Cdc28p substrate 9e-050.00143 S000001013FMP12YHL021CuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 9e-050.00143 S000000952SPI1YER150WverifiedGPI-anchored, serine/threonine rich cell wall protein ofunknown function; basal expression requiresMsn2p/Msn4p; expression is induced underconditions of stress and during the diauxicshift; similar to Sed1p 9e-050.00143 S000002559GIR2YDR152WverifiedHighly-acidic cytoplasmic RWD domain-containing protein ofunknown function, sensitive to proteolysis,N-terminal region has high content of acidicamino acid residues, putative IUP(intrinsically unstructured protein) 9e-050.00143 S000005745STE13YOR219CverifiedDipeptidyl aminopeptidase, Golgi integral membrane protein thatcleaves on the carboxyl side of repeating-X-Ala- sequences, required for maturation ofalpha factor, transcription is induced bya-factor 9e-050.00143 S000005233PCL1YNL289WverifiedPho85 cyclin of the Pcl1,2-like subfamily, involved in entryinto the mitotic cell cycle and regulation ofmorphogenesis, localizes to sites of polarizedcell growth 9e-050.00143 S000003475FMP43YGR243WuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 9e-050.00143 S000001307PIG2YIL045WverifiedPutative type-1 protein phosphatase targeting subunit thattethers Glc7p type-1 protein phosphatase toGsy2p glycogen synthase 9e-050.00143 S000006151YPL230WUncharacterizedPutative protein of unknown function 9e-050.00143 S000005091LSM7YNL147WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 9e-050.00143&radic S000005331YNR048WVerifiedProtein proposed to interact with phospholipid translocases, shares similarity to Cdc50p 9e-050.00143 S000001714MRPL13YKR006CverifiedMitochondrial ribosomal protein of the large subunit, notessential for mitochondrial translation 9e-050.00143 S000002602MSS116YDR194CverifiedDEAD-box protein required for efficient splicing ofmitochondrial Group I and II introns; non-polarRNA helicase that also facilities strandannealing 9e-050.00143 S000001626LTV1YKL143WverifiedComponent of the GSE complex, which is required for propersorting of amino acid permease Gap1p; requiredfor ribosomal small subunit export fromnucleus; required for growth at low temperature 9e-050.00143 S000000447ALG7YBR243CverifiedUDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-Pfrom UDP-GlcNac to Dol-P in the ER in the firststep of the dolichol pathway of proteinasparagine-linked glycosylation; inhibited bytunicamycin 9e-050.00143 S000001763RHO4YKR055WverifiedNon-essential small GTPase of the Rho/Rac subfamily of Ras-likeproteins, likely to be involved in theestablishment of cell polarity 9e-050.00143 S000006387DPM1YPR183WverifiedDolichol phosphate mannose (Dol-P-Man) synthase of the ERmembrane, catalyzes the formation of Dol-P-Manfrom Dol-P and GDP-Man; required for glycosylphosphatidylinositol membrane anchoring, Omannosylation, and protein glycosylation 9e-050.00143 S000005883YOR356WUncharacterizedHypothetical protein 9e-050.00143 S000028838YIR021W-AUncharacterizedPutative protein of unknown function, identified by expression profiling and mass spectrometry 9e-050.00143 S000003143SAE2YGL175CverifiedProtein with a role in accurate meiotic and mitoticdouble-strand break repair; phosphorylated inresponse to DNA damage and required for normalresistance to DNA-damaging agents 9e-050.00143 S000001727IRS4YKR019CverifiedProtein involved in regulation of phosphatidylinositol4,5-bisphosphate concentrations; Irs4p andTax4p bind and activate the phosphatase Inp51p;mutation confers an increase in rDNA silencing 9e-050.00143 S000000614MAK31YCR020C-AverifiedNon-catalytic subunit of N-terminal acetyltransferase of theNatC type; required for replication of dsRNAvirus; member of the Sm protein family 9e-050.00143 S000004184YLR194CUncharacterizedStructural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress 9e-050.00143 S000003455HSV2YGR223CverifiedPhosphatidylinositol 3,5-bisphosphate-binding protein,predicted to fold as a seven-bladedbeta-propeller; displays punctate cytoplasmiclocalization 9e-050.00143&radic S000005594VAM10YOR068CverifiedProtein involved in vacuole morphogenesis; acts at an earlystep of homotypic vacuole fusion that isrequired for vacuole tethering 9e-050.00143 S000003694CIS3YJL158CverifiedMannose-containing glycoprotein constituent of the cell wall;member of the PIR (proteins with internalrepeats) family 9e-050.00143 S000004834FMP42YMR221CuncharacterizedPutative protein of unknown function; the authentic, non-taggedprotein is detected in highly purifiedmitochondria in high-throughput studies 9e-050.00143 S000002819DFM1YDR411CuncharacterizedER localized derlin-like family member involved in ER stressand homeostasis; not involved in ERAD orsubstrate retrotranslocation; interacts withCDC48; contains four transmembrane domains andtwo SHP boxes 9e-050.00143 S000001166NDT80YHR124WverifiedMeiosis-specific transcription factor required for exit frompachytene and for full meiotic recombination;activates middle sporulation genes; competeswith Sum1p for binding to promoters containingmiddle sporulation elements (MSE) 9e-050.00143 S000000336AGP2YBR132CverifiedHigh affinity polyamine permease, preferentially usesspermidine over putrescine; expression isdown-regulated by osmotic stress; plasmamembrane carnitine transporter, also functionsas a low-affinity amino acid permease 9e-050.00143 S000000240CSG2YBR036CverifiedEndoplasmic reticulum membrane protein, required formannosylation of inositolphosphorylceramide andfor growth at high calcium concentrations 9e-050.00142 S000000206RER2YBR002CverifiedCis-prenyltransferase involved in dolichol synthesis;participates in endoplasmic reticulum (ER)protein sorting 9e-050.00142 S000001570CYT2YKL087CverifiedCytochrome c1 heme lyase, involved in maturation of cytochromec1, which is a subunit of the mitochondrialubiquinol-cytochrome-c reductase; links hemecovalently to apocytochrome c1 9e-050.00142 S000003233YGR001CUncharacterizedPutative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae 9e-050.00142 S000000488YBR284WUncharacterizedPutative protein of unknown function; YBR284W is not an essential gene; null mutant exhibits decreased resistance to rapamycin and wortmannin 9e-050.00142 S000001873GAT1YFL021WverifiedTranscriptional activator of genes involved in nitrogencatabolite repression, member of the GATAfamily of DNA binding proteins; activity andlocalization regulated by nitrogen limitationand Ure2p 9e-050.00142 S000001353YIL091CUncharacterizedProtein required for cell viability 9e-050.00142&radic S000004815ERG2YMR202WverifiedC-8 sterol isomerase, catalyzes the isomerization of thedelta-8 double bond to the delta-7 position atan intermediate step in ergosterol biosynthesis 9e-050.00142 S000001032ARN1YHL040CverifiedTransporter, member of the ARN family of transporters thatspecifically recognize siderophore-ironchelates; responsible for uptake of iron boundto ferrirubin, ferrirhodin, and relatedsiderophores 9e-050.00142 S000002140YAL064C-AUncharacterizedHypothetical protein 9e-050.00142&radic S000000138FUI1YBL042CverifiedHigh affinity uridine permease, localized to the plasmamembrane; not involved in uracil transport 9e-050.00142&radic S000004237IRC20YLR247CuncharacterizedPutative helicase; localized to mitochondria and the nucleus;YLR247C is not an essential gene; null mutantdisplays increased levels of spontaneous Rad52foci 9e-050.00142 S000004283SEC72YLR292CverifiedNon-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66pand Sec72p); with Sec61 complex, Kar2p/BiP andLhs1p forms a channel competent forSRP-dependent and post-translationalSRP-independent protein targeting and importinto the ER 9e-050.00142 S000006279OPY2YPR075CverifiedIntegral membrane protein that functions in the signalingbranch of the high-osmolarity glycerol (HOG)pathway; interacts with Ste50p; overproductionblocks cell cycle arrest in the presence ofmating pheromone 9e-050.00142 S000002506BMH2YDR099Wverified14-3-3 protein, minor isoform; binds proteins and DNA, involvedin regulation of many processes includingexocytosis and vesicle transport, Ras/MAPKsignaling during pseudohyphal development,rapamycin-sensitive signaling, and others 9e-050.00142&radic S000005036YNL092WUncharacterizedPutative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene 9e-050.00142 S000004781YMR171CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to endosomes; mRNA is targeted to the bud via the mRNA transport system involving She2p: YMR171C is not an essential gene 9e-050.00142&radic S000006335NAT3YPR131CverifiedCatalytic subunit of the NatB N-terminal acetyltransferase,which catalyzes acetylation of theamino-terminal methionine residues of allproteins beginning with Met-Asp or Met-Glu andof some proteins beginning with Met-Asn orMet-Met 9e-050.00142 S000005329TRM112YNR046WverifiedSubunit of an adoMet-dependent tRNA methyltransferase (MTase)complex (Trm11p-Trm112p), required for themethylation of the guanosine nucleotide atposition 10 (m2G10) in tRNAs; putative zincbinding subunit of other MTase-related proteins 9e-050.00142 S000005105CBK1YNL161WverifiedSerine/threonine protein kinase that regulates cellmorphogenesis pathways; involved in cell wallbiosynthesis, apical growth, proper matingprojection morphology, bipolar bud siteselection in diploid cells, and cell separation 9e-050.00142 S000006370MRP2YPR166CverifiedMitochondrial ribosomal protein of the small subunit 9e-050.00142 S000005019IMP4YNL075WverifiedComponent of the SSU processome, which is required for pre-18SrRNA processing; interacts with Mpp10p; memberof a superfamily of proteins that contain asigma(70)-like motif and associate with RNAs 9e-050.00142 S000000132YBL036CVerifiedSingle-domain racemase, possibly non-specific due to the lack of the second domain, which presumably determines specificity 9e-050.00142 S000004097REX3YLR107WverifiedRNA exonuclease; required for maturation of the RNA componentof RNase MRP; functions redundantly with Rnh70pand Rex2p in processing of U5 snRNA and RNase PRNA; member of RNase D family of exonucleases 9e-050.00142 S000000936YER134CUncharacterizedHypothetical protein 9e-050.00142 S000005790DSE3YOR264WverifiedDaughter cell-specific protein, may help establish daughterfate 9e-050.00142 S000001742DAL80YKR034WverifiedNegative regulator of genes in multiple nitrogen degradationpathways; expression is regulated by nitrogenlevels and by Gln3p; member of the GATA-bindingfamily, forms homodimers and heterodimers withDeh1p 9e-050.00142 S000005237MSB3YNL293WverifiedGTPase-activating protein for Sec4p and several other RabGTPases, regulates exocytosis via its action onSec4p, also required for proper actinorganization; similar to Msb4p; both Msb3p andMsb4p localize to sites of polarized growth 9e-050.00142 S000002294RDI1YDL135CverifiedRho GDP dissociation inhibitor involved in the localization andregulation of Cdc42p 9e-050.00142 S000004098YLR108CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene 9e-050.00142 S000000807YND1YER005WverifiedApyrase with wide substrate specificity, involved in preventingthe inhibition of glycosylation by hydrolyzingnucleoside tri- and diphosphates which areinhibitors of glycotransferases; partiallyredundant with Gda1p 9e-050.00142 S000003589PEP8YJL053WverifiedVacuolar protein sorting protein that forms part of themultimeric membrane-associated retromer complexalong with Vps35p, Vps29p, Vps17p, and Vps5p;essential for endosome-to-Golgi retrogradeprotein transport 9e-050.00142&radic S000003896MCM22YJR135CverifiedProtein involved in minichromosome maintenance; component ofthe kinetochore; binds to centromeric DNA in aCtf19p-dependent manner 9e-050.00142 S000002794MUS81YDR386WverifiedHelix-hairpin-helix protein, involved in DNA repair andreplication fork stability; functions as anendonuclease in complex with Mms4p; interactswith Rad54p 9e-050.00142 S000000136ERD2YBL040CverifiedIntegral membrane protein that binds to the HDEL motif inproteins destined for retention in theendoplasmic reticulum; has a role inmaintenance of normal levels of ER-residentproteins 9e-050.00142 S000003876YJR115WUncharacterizedPutative protein of unknown function 9e-050.00142 S000003366CAF130YGR134WverifiedPart of the evolutionarily-conserved CCR4-NOT transcriptionalregulatory complex involved in controlling mRNAinitiation, elongation, and degradation 9e-050.00142 S000005495MED7YOL135CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; essential fortranscriptional regulation 9e-050.00142&radic S000000753CUP5YEL027WverifiedProteolipid subunit of the vacuolar H(+)-ATPase V0 sector(subunit c; dicyclohexylcarbodiimide bindingsubunit); required for vacuolar acidificationand important for copper and iron metal ionhomeostasis 9e-050.00142 S000113589YPR145C-AUncharacterizedPutative protein of unknown function 9e-050.00142 S000005392OPI10YOL032WverifiedProtein with a possible role in phospholipid biosynthesis,based on inositol-excreting phenotype of thenull mutant and its suppression by exogenouscholine 9e-050.00142 S000005337ESF2YNR054CverifiedEssential nucleolar protein involved in pre-18S rRNAprocessing; component of the small subunit(SSU) processome; has sequence similarity tomABT1, a mouse transcription activator 9e-050.00142&radic S000003031PUS2YGL063WverifiedPutative pseudouridine synthase 9e-050.00142 S000001656SNU114YKL173WverifiedGTPase component of U5 snRNP involved in mRNA splicing viaspliceosome; binds directly to U5 snRNA;proposed to be involved in conformationalchanges of the spliceosome; similarity toribosomal translocation factor EF-2 9e-050.00142 S000002492AFR1YDR085CverifiedAlpha-factor pheromone receptor regulator, negatively regulatespheromone receptor signaling; required fornormal mating projection (shmoo) formation;interacts with Cdc12p 9e-050.00142 S000003973COF1YLL050CverifiedCofilin, promotes actin filament depolarization in apH-dependent manner; binds both actin monomersand filaments and severs filaments , thought tobe regulated by phosphorylation at SER4,ubiquitous and essential in eukaryotes 9e-050.00142 S000028421HSK3YKL138C-AverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; is transferred to thekinetochore prior to mitosis 9e-050.00142 S000004012SDO1YLR022CuncharacterizedEssential protein involved in RNA metabolism, one of two yeasthomologs (with Yhr087wp) of the human proteinSBDS responsible for autosomal recessiveShwachman-Bodian-Diamond Syndrome, alsoconserved in Archaea 9e-050.00142 S000004335GAS2YLR343WuncharacterizedPutative 1,3-beta-glucanosyltransferase, has similarity toGas1p 9e-050.00142 S000004486RPS17AYML024WverifiedRibosomal protein 51 (rp51) of the small (40s) subunit; nearlyidentical to Rps17Bp and has similarity to ratS17 ribosomal protein 9e-050.00142 S000002425YDR018CUncharacterizedProbable membrane protein with three predicted transmembrane domains; homologous to Ybr042cp, similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; null exhibits no apparent phenotype 9e-050.00142 S000000786PRB1YEL060CverifiedVacuolar proteinase B (yscB), a serine protease of thesubtilisin family; involved in proteindegradation in the vacuole and required forfull protein degradation during sporulation 9e-050.00142 S000001131GAR1YHR089CverifiedProtein component of the H/ACA snoRNP pseudouridylase complex,involved in the modification and cleavage ofthe 18S pre-rRNA 9e-050.00142&radic S000004493NDC1YML031WverifiedNuclear envelope protein with multiple putative transmembranedomains, required for nuclear pore complexassembly and spindle pole body duplication;required for meiosis II 9e-050.00142 S000003931DRS1YLL008WverifiedNucleolar DEAD-box protein required for ribosome assembly andfunction, including synthesis of 60S ribosomalsubunits; constituent of 66S pre-ribosomalparticles 9e-050.00142&radic S000006127YPL206CUncharacterizedProtein that plays a role in metabolism of glycerophosphocholine to phosphatidylcholine; contains glycerophosphodiester phosphodiesterase motifs 9e-050.00142 S000004136SPE4YLR146CverifiedSpermine synthase, required for the biosynthesis of spermineand also involved in biosynthesis ofpantothenic acid 9e-050.00142 S000005116APC1YNL172WverifiedLargest subunit of the Anaphase-Promoting Complex/Cyclosome(APC/C), which is a ubiquitin-protein ligaserequired for degradation of anaphaseinhibitors, including mitotic cyclins, duringthe metaphase/anaphase transition 9e-050.00142 S000003585YJL049WUncharacterizedPutative protein of unknown function; YJL049W is a non-essential gene 9e-050.00142 S000004230VPS34YLR240WverifiedPhosphatidylinositol 3-kinase responsible for the synthesis ofphosphatidylinositol 3-phosphate; formsmembrane-associated signal transduction complexwith Vps15p to regulate protein sorting;activated by the GTP-bound form of Gpa1p 9e-050.00142 S000005039YNL095CUncharacterizedPutative protein of unknown function predicted to contain a transmembrane domain; YNL095C is not an essential gene 9e-050.00142 S000004089ICT1YLR099CverifiedProtein of unknown function, null mutation leads to an increasein sensitivity to Calcofluor white; expressionof the gene is induced in the presence ofisooctane 9e-050.00142 S000005966VPS16YPL045WverifiedSubunit of the homotypic vacuole fusion and vacuole proteinsorting (HOPS) complex; part of the Class C Vpscomplex essential for membrane docking andfusion at both the Golgi-to-endosome andendosome-to-vacuole stages of protein transport 9e-050.00142 S000004791SPT21YMR179WverifiedProtein required for normal transcription at several lociincluding HTA2-HTB2 and HHF2-HHT2, but notrequired at the other histone loci;functionally related to Spt10p; involved intelomere maintenance 9e-050.00142 S000003614PRY3YJL078CverifiedProtein of unknown function, has similarity to Pry1p and Pry2pand to the plant PR-1 class of pathogen relatedproteins 9e-050.00142 S000002667YAP6YDR259CverifiedPutative basic leucine zipper (bZIP) transcription factor;overexpression increases sodium and lithiumtolerance 9e-050.00142 S000002844PPZ2YDR436WverifiedSerine/threonine protein phosphatase Z, isoform of Ppz1p;involved in regulation of potassium transport,which affects osmotic stability, cell cycleprogression, and halotolerance 9e-050.00142 S000000359CNS1YBR155WverifiedTPR-containing co-chaperone; binds both Hsp82p (Hsp90) andSsa1p (Hsp70) and stimulates the ATPaseactivity of SSA1, ts mutants reduce Hsp82pfunction while over expression suppresses thephenotypes of an HSP82 ts allele and a cpr7deletion 9e-050.00142 S000005613YVC1YOR087WverifiedVacuolar cation channel, mediates release of Ca(2+) from thevacuole in response to hyperosmotic shock 9e-050.00142 S000005305MRPL50YNR022CverifiedMitochondrial ribosomal protein of the large subunit, notessential for mitochondrial translation 9e-050.00142 S000006168YPL247CUncharacterizedHypothetical protein 9e-050.00142 S000000393RPS9BYBR189WverifiedProtein component of the small (40S) ribosomal subunit; nearlyidentical to Rps9Ap and has similarity to E.coli S4 and rat S9 ribosomal proteins 9e-050.00142 S000002803SXM1YDR395WverifiedNuclear transport factor (karyopherin) involved in proteintransport between the cytoplasm andnucleoplasm; similar to Nmd5p, Cse1p, Lph2p,and the human cellular apoptosis susceptibilityprotein, CAS1 9e-050.00142 S000001417GUT2YIL155CverifiedMitochondrial glycerol-3-phosphate dehydrogenase; expression isrepressed by both glucose and cAMP andderepressed by non-fermentable carbon sourcesin a Snf1p, Rsf1p, Hap2/3/4/5 complex dependentmanner 9e-050.00142 S000005197TEX1YNL253WverifiedProtein involved in mRNA export, component of the transcriptionexport (TREX) complex 9e-050.00142 S000001441MPH1YIR002CverifiedMember of the DEAH family of helicases, functions in anerror-free DNA damage bypass pathway thatinvolves homologous recombination, mutationsconfer a mutator phenotype 9e-050.00142 S000003354YGR122WUncharacterizedPutative protein of unknown function; deletion mutants do not properly process Rim101p and have decreased resistance to rapamycin; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 9e-050.00142 S000002695YDR287WUncharacterizedinositol monophosphatase 9e-050.00142 S000000133APL3YBL037WverifiedAlpha-adaptin, large subunit of the clathrin associated proteincomplex (AP-2); involved in vesicle mediatedtransport 9e-050.00142 S000001186DSE2YHR143WverifiedDaughter cell-specific secreted protein with similarity toglucanases, degrades cell wall from thedaughter side causing daughter to separate frommother; expression is repressed by cAMP 9e-050.00142 S000003707YJL171CVerifiedGPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein 9e-050.00142 S000001668ASH1YKL185WverifiedZinc-finger inhibitor of HO transcription; mRNA is localizedand translated in the distal tip of anaphasecells, resulting in accumulation of Ash1p indaughter cell nuclei and inhibition of HOexpression; potential Cdc28p substrate 9e-050.00142 S000002282YDL124WVerifiedNADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters 9e-050.00142 S000003557BBC1YJL020CverifiedProtein possibly involved in assembly of actin patches;interacts with an actin assembly factor Las17pand with the SH3 domains of Type I myosinsMyo3p and Myo5p; localized predominantly tocortical actin patches 9e-050.00142 S000003052GUP1YGL084CverifiedPlasma membrane protein with a possible role in proton symportof glycerol; member of the MBOAT family ofputative membrane-bound O-acyltransferases 9e-050.00142 S000000112FUS3YBL016WverifiedMitogen-activated protein kinase involved in mating pheromoneresponse; activated by phosphorylation bySte7p; provides specificity during the matingvs. filamentous growth response byphosphorylating transcriptional and cytoplasmictargets 9e-050.00142 S000028854YOL097W-AUncharacterizedPutative protein of unknown function; identified by expression profiling and mass spectrometry 9e-050.00142 S000028437SLO1YER180C-AverifiedProtein interacting with Arl3p, which is a GTPase of the Rassuperfamily involved in vesicle-tethering atthe Golgi; putative ortholog of human SCOCO 9e-050.00142 S000005778TMA16YOR252WverifiedProtein of unknown function that associates with ribosomes 9e-050.00142 S000004148ASP3-3YLR158CverifiedCell-wall L-asparaginase II, involved in asparagine catabolism;expression is induced during nitrogenstarvation; four copies of ASP3 are present inthe genome reference strain S288C 9e-050.00142 S000000017FUN30YAL019WverifiedProtein whose overexpression affects chromosome stability,potential Cdc28p substrate; homolog of Snf2p;the authentic, non-tagged protein is detectedin highly purified mitochondria inhigh-throughput studies 9e-050.00142 S000004100CCW12YLR110CverifiedCell wall protein, mutants are defective in mating andagglutination, expression is downregulated byalpha-factor 9e-050.00142 S000003513YOR1YGR281WverifiedPlasma membrane transporter of the ATP-binding cassette (ABC)family, mediates export of many differentorganic anions including oligomycin 9e-050.00142 S000001009YHL017WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles 9e-050.00142 S000006042MEI5YPL121CverifiedMeiosis specific protein involved in DMC1-dependent meioticrecombination, forms heterodimer with Sae3p;proposed to be an assembly factor for Dmc1p 9e-050.00142 S000001798PXL1YKR090WverifiedLIM domain-containing protein that localizes to sites ofpolarized growth, required for selection and/ormaintenance of polarized growth sites, maymodulate signaling by the GTPases Cdc42p andRho1p; has similarity to metazoan paxillin 9e-050.00142 S000005447YOL087CUncharacterizedHypothetical protein 9e-050.00142 S000000278YBR074WUncharacterizedPutative metalloprotease 9e-050.00142 S000000059FLO9YAL063CverifiedLectin-like protein with similarity to Flo1p, thought to beexpressed and involved in flocculation 9e-050.00142&radic S000005904ATF1YOR377WverifiedAlcohol acetyltransferase with potential roles in lipid andsterol metabolism; responsible for the majorpart of volatile acetate ester productionduring fermentation 9e-050.00142 S000005330YNR047WUncharacterizedPutative protein kinase that, when overexpressed, interferes with pheromone-induced growth arrest; localizes to the cytoplasm; potential Cdc28p substrate 9e-050.00142&radic S000004095SEN2YLR105CverifiedSubunit of the tRNA splicing endonuclease, which is composed ofSen2p, Sen15p, Sen34p, and Sen54p; Sen2pcontains the active site for tRNA 5' splicesite cleavage and has similarity to Sen34p andto Archaeal tRNA splicing endonuclease 9e-050.00142 S000002807HPT1YDR399WverifiedDimeric hypoxanthine-guanine phosphoribosyltransferase,catalyzes the formation of both inosinemonophosphate and guanosine monophosphate;mutations in the human homolog HPRT1 can causeLesch-Nyhan syndrome and Kelley-Seegmillersyndrome 9e-050.00142 S000004013IZH3YLR023CverifiedMembrane protein involved in zinc metabolism, member of thefour-protein IZH family, expression induced byzinc deficiency; deletion reduces sensitivityto elevated zinc and shortens lag phase,overexpression reduces Zap1p activity 9e-050.00142 S000000207COQ1YBR003WverifiedHexaprenyl pyrophosphate synthetase, catalyzes the first stepin ubiquinone (coenzyme Q) biosynthesis 9e-050.00142 S000001405SSL2YIL143CverifiedComponent of the holoenzyme form of RNA polymerasetranscription factor TFIIH, has DNA-dependentATPase/helicase activity and is required, withRad3p, for unwinding promoter DNA; involved inDNA repair; homolog of human ERCC3 9e-050.00142 S000003445RTA1YGR213CverifiedProtein involved in 7-aminocholesterol resistance; has sevenpotential membrane-spanning regions 9e-050.00142 S000005388YAP7YOL028CverifiedPutative basic leucine zipper (bZIP) transcription factor 9e-050.00142 S000003834OPI3YJR073CverifiedPhospholipid methyltransferase(methylene-fatty-acyl-phospholipid synthase),catalyzes the last two steps inphosphatidylcholine biosynthesis 9e-050.00142 S000001139YHR097CUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus 9e-050.00142 S000004947RLP7YNL002CverifiedNucleolar protein with similarity to large ribosomal subunit L7proteins; constituent of 66S pre-ribosomalparticles; plays an essential role inprocessing of precursors to the large ribosomalsubunit RNAs 9e-050.00142 S000028550YGR121W-AUncharacterizedPutative protein of unknown function 9e-050.00142 S000004492YML030WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YML030W is not an essential gene 9e-050.00142 S000007245COX19YLL018C-AverifiedProtein required for cytochrome c oxidase assembly, located inthe cytosol and mitochondrial intermembranespace; putative copper metallochaperone thatdelivers copper to cytochrome c oxidase 9e-050.00142 S000003759PAU1YJL223CverifiedPart of 23-member seripauperin multigene family encoded mainlyin subtelomeric regions, active duringalcoholic fermentation, regulated byanaerobiosis, negatively regulated by oxygen,repressed by heme 9e-050.00142&radic S000003017TIF4632YGL049CverifiedTranslation initiation factor eIF4G, subunit of the mRNAcap-binding protein complex (eIF4F) that alsocontains eIF4E (Cdc33p); associates with thepoly(A)-binding protein Pab1p, also interactswith eIF4A (Tif1p); homologous to Tif4631p 9e-050.00142 S000003201TAN1YGL232WverifiedPutative tRNA acetyltransferase, RNA-binding protein requiredfor the formation of the modified nucleosideN(4)-acetylcytidine in serine and leucine tRNAsbut not required for the same modification in18S rRNA 9e-050.00142 S000003381YGR149WUncharacterizedPutative protein of unknown function; predicted to be an integal membrane protein 9e-050.00142 S000006046KAP120YPL125WverifiedKaryopherin with a role in the assembly or export of 60Sribosomal subunits 9e-050.00142 S000000814PRE1YER012Wverified20S proteasome beta-type subunit; localizes to the nucleusthroughout the cell cycle 9e-050.00142 S000001946PRE4YFR050Cverified20S proteasome beta-type subunit 9e-050.00142 S000002990STT3YGL022WverifiedSubunit of the oligosaccharyltransferase complex of the ERlumen, which catalyzes asparagine-linkedglycosylation of newly synthesized proteins;forms a subcomplex with Ost3p and Ost4p and isdirectly involved in catalysis 9e-050.00142 S000004742GID8YMR135CverifiedProtein of unknown function, involved in proteasome-dependentcatabolite inactivation offructose-1,6-bisphosphatase; contains LisH andCTLH domains, like Vid30p; dosage-dependentregulator of START 9e-050.00142 S000003582YJL046WUncharacterizedPutative protein of unknown function, predicted to encode a lipoate-protein ligase A family member; deletion mutant has a respiratory growth defect 9e-050.00142 S000005944MET12YPL023CverifiedIsozyme of methylenetetrahydrofolate reductase, catalyzes thereduction of 5,10-methylenetetrahydrofolate to5-methyltetrahydrofolate in the methioninebiosynthesis pathway 9e-050.00142 S000003272KSS1YGR040WverifiedMitogen-activated protein kinase (MAPK) involved in signaltransduction pathways that control filamentousgrowth and pheromone response 9e-050.00142&radic S000001737SET3YKR029CverifiedDefining member of the SET3 histone deacetylase complex whichis a meiosis-specific repressor of sporulationgenes; necessary for efficient transcription byRNAPII; one of two yeast proteins that containsboth SET and PHD domains 9e-050.00142 S000004717YMR111CUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene 9e-050.00142 S000004507RRN11YML043CverifiedProtein required for rDNA transcription by RNA polymerase I,component of the core factor (CF) of rDNAtranscription factor, which also contains Rrn6pand Rrn7p 9e-050.00142&radic S000003639GSM1YJL103CuncharacterizedPutative zinc cluster protein of unknown function; proposed tobe involved in the regulation of energymetabolism, based on patterns of expression andsequence analysis 9e-050.00142 S000002972RPN14YGL004CuncharacterizedPutative non-ATPase subunit of the 19S regulatory particle ofthe 26S proteasome; localized to the cytoplasm 9e-050.00142 S000003126RCK1YGL158WverifiedProtein kinase involved in the response to oxidative stress;identified as suppressor of S. pombe cell cyclecheckpoint mutations 9e-050.00142 S000001458MUC1YIR019CverifiedGPI-anchored cell surface glycoprotein required for diploidpseudohyphal formation and haploid invasivegrowth, transcriptionally regulated by the MAPKpathway (via Ste12p and Tec1p) and the cAMPpathway (via Flo8p) 9e-050.00142 S000004135RMP1YLR145WverifiedEssential component of RNase MRP, which processes pre-rRNA inthe nucleolus and also processes mitochondrialRNAs to create RNA primers for DNA replication 9e-050.00142&radic S000004794RGM1YMR182CverifiedPutative transcriptional repressor with proline-rich zincfingers; overproduction impairs cell growth 9e-050.00141 S000028561YLR154C-GUncharacterizedPutative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF is contained within RDN25-2 and RDN37-2 9e-050.00141 S000000078PRM9YAR031WverifiedPheromone-regulated protein with 3 predicted transmembranesegments and an FF sequence, a motif involvedin COPII binding; member of DUP240 gene family 9e-050.00141&radic S000003294COX18YGR062CverifiedMitochondrial inner membrane protein, required for export ofthe Cox2p C terminus from the mitochondrialmatrix to the intermembrane space during itsassembly into cytochrome c oxidase; similar toOxa2p of N. crassa 9e-050.00141 S000000523LEU2YCL018WverifiedBeta-isopropylmalate dehydrogenase, catalyzes the third step inthe leucine biosynthesis pathway 9e-050.00141&radic S000005954YPL033CUncharacterizedHypothetical protein 9e-050.00141 S000002520PDS1YDR113CverifiedSecurin that inhibits anaphase by binding separin Esp1p, alsoblocks cyclin destruction and mitotic exit,essential for cell cycle arrest in mitosis inthe presence of DNA damage or aberrant mitoticspindles; also present in meiotic nuclei 9e-050.00141 S000003399CLC1YGR167WverifiedClathrin light chain, subunit of the major coat proteininvolved in intracellular protein transport andendocytosis; thought to regulate clathrinfunction, two Clathrin heavy chains (CHC1) formthe clathrin triskelion structural component 9e-050.00141 S000000996MRP4YHL004WverifiedMitochondrial ribosomal protein of the small subunit 9e-050.00141 S000006206PDH1YPR002WverifiedMitochondrial protein that participates in respiration, inducedby diauxic shift; homologous to E. coli PrpD,may take part in the conversion of2-methylcitrate to 2-methylisocitrate 9e-050.00141 S000000966CHD1YER164WverifiedNucleosome remodeling factor that functions in regulation oftranscription elongation; contains a chromodomain, a helicase domain and a DNA-bindingdomain; component of both the SAGA and SILKcomplexes 9e-050.00141 S000000362AMN1YBR158WverifiedProtein required for daughter cell separation, multiple mitoticcheckpoints, and chromosome stability; contains12 degenerate leucine-rich repeat motifs;expression is induced by the Mitotic ExitNetwork (MEN) 9e-050.00141 S000006138BMS1YPL217CverifiedEssential conserved nucleolar GTP-binding protein required forsynthesis of 40S ribosomal subunits and forprocessing of the 35S pre-rRNA at sites A0, A1,and A2; interacts with Rcl1p, has similarity toTsr1p 9e-050.00141 S000003538PRE3YJL001Wverified20S proteasome beta-type subunit, responsible for cleavageafter acidic residues in peptides 9e-050.00141 S000005992YPL071CUncharacterizedHypothetical protein 9e-050.00141 S000005972ARL3YPL051WverifiedGTPase of the Ras superfamily required to recruit Arl1p to theGolgi; similar to ADP-ribosylation factor 9e-050.00141 S000002257BUG1YDL099WuncharacterizedProtein of unknown function; green fluorescent protein(GFP)-fusion protein localizes to the cytoplasmin a punctate pattern 9e-050.00141 S000000148SAS3YBL052CverifiedHistone acetyltransferase catalytic subunit of NuA3 complexthat acetylates histone H3, involved intranscriptional silencing; homolog of themammalian MOZ proto-oncogene; sas3 gcn5 doublemutation confers lethality 9e-050.00141 S000005804HEM4YOR278WverifiedUroporphyrinogen III synthase, catalyzes the conversion ofhydroxymethylbilane to uroporphyrinogen III,the fourth step in the heme biosyntheticpathway 9e-050.00141 S000003487COQ6YGR255CverifiedPutative flavin-dependent monooxygenase, involved in ubiquinone(Coenzyme Q) biosynthesis; located on thematrix side of the mitochondrial inner membrane 9e-050.00141 S000002385GCS1YDL226CverifiedADP-ribosylation factor GTPase activating protein (ARF GAP),involved in ER-Golgi transport; sharesfunctional similarity with Glo3p 9e-050.00141 S000000989YER187WUncharacterizedHypothetical protein 9e-050.00141 S000001213NMD3YHR170WverifiedProtein involved in nuclear export of the large ribosomalsubunit; acts as a Crm1p-dependent adapterprotein for export of nascent ribosomalsubunits through the nuclear pore complex 9e-050.00141 S000003344SHY1YGR112WverifiedMitochondrial inner membrane protein required for normalrespiration, possible chaperone involved inassembly of cytochrome c oxidase; similar toSURF1 from mammals, chickens, and D.melanogaster 9e-050.00141 S000000739VAC8YEL013WverifiedPhosphorylated vacuolar membrane protein that interacts withAtg13p, required for the cytoplasm-to-vacuoletargeting (Cvt) pathway; interacts with Nvj1pto form nucleus-vacuole junctions 9e-050.00141 S000002256SNU23YDL098CverifiedComponent of U4/U6.U5 snRNP involved in mRNA splicing viaspliceosome 9e-050.00141 S000001144KIC1YHR102WverifiedProtein kinase of the PAK/Ste20 kinase family, required forcell integrity possibly through regulating1,6-beta-glucan levels in the wall; physicallyinteracts with Cdc31p (centrin), which is acomponent of the spindle pole body 9e-050.00141 S000006266FCY1YPR062WverifiedCytosine deaminase, zinc metalloenzyme that catalyzes thehydrolytic deamination of cytosine to uracil;of biomedical interest because it alsocatalyzes the deamination of 5-fluorocytosine(5FC) to form anticancer drug 5-fluorouracil(5FU) 9e-050.00141 S000004537TCB3YML072CverifiedLipid-binding protein, localized to the bud via specific mRNAtransport; non-tagged protein localizes tomitochondria and GFP-fusion protein localizesto the cell periphery; C-termini of Tcb1p,Tcb2p and Tcb3p interact 9e-050.00141 S000003912DAN4YJR151CverifiedCell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p,and Tir4p; expressed under anaerobicconditions, completely repressed during aerobicgrowth 9e-050.00141 S000005718THI72YOR192CuncharacterizedTransporter of thiamine or related compound; shares sequencesimilarity with Thi7p 9e-050.00141 S000006329YLH47YPR125WuncharacterizedMitochondrial inner membrane protein exposed to themitochondrial matrix, associates withmitochondrial ribosomes, NOT required forrespiratory growth; homolog of human Letm1, aprotein implicated in Wolf-Hirschhorn syndrome 9e-050.00141 S000003937YLL014WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLL014W is not an essential gene 9e-050.00141 S000001757FMP46YKR049CverifiedPutative redox protein containing a thioredoxin fold; theauthentic, non-tagged protein is detected inhighly purified mitochondria in high-throughputstudies 9e-050.00141 S000004008POM34YLR018CverifiedIntegral membrane protein of the nuclear pore; has an importantrole in maintaining the architecture of thepore complex 9e-050.00141 S000001279VID28YIL017CverifiedProtein involved in proteasome-dependent catabolite degradationof fructose-1,6-bisphosphatase (FBPase);localized to the nucleus and the cytoplasm 9e-050.00141 S000005166SSU72YNL222WverifiedTranscription/RNA-processing factor that associates with TFIIBand cleavage/polyadenylation factor Pta1p;exhibits phosphatase activity on serine-5 ofthe RNA polymerase II C-terminal domain;affects start site selection in vivo 9e-050.00141 S000000327TFC1YBR123CverifiedOne of six subunits of the RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part of theTauA globular domain of TFIIIC that binds DNAat the BoxA promoter sites of tRNA and similargenes; human homolog is TFIIIC-63 9e-050.00141 S000004620YMR018WUncharacterizedPutative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene 9e-050.00141 S000003207CSE1YGL238WverifiedNuclear envelope protein that mediates the nuclear export ofimportin alpha (Srp1p), homolog of metazoan CASprotein, required for accurate chromosomesegregation 9e-050.00141&radic S000003188YGL220WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus 9e-050.00141 S00000223