Yfunc lets you browse current and predicted gene functions in yeast

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Prediction of GO:0044427 "chromosomal part"

GO branch: CC
Number of currently annotated genes: 191

* the highlighted genes are those "interesting" predictions that
(1) are not currently annotated to this function,
(2) are not annotated with any ancestor GO terms (except the root term),
(3) have a projected precision score > 0.5
Histogram of scores for current annotations (annotated with the target function),
and novel predictions (not annotated with the target function)
Histogram of scores for current annotations, and predictions
SGDIDcommon namesystematic namefeature typeSGD descriptionCYGD reportannotation statusprediction scoreprojected precisionTop 10 important variables from random forest Huh:nucleusKumar:nucleusLum:MenadioneLum:CycloheximideHarbison:FHL1_H2O2HiHarbison:IME1_H2O2HiKumar:cyto.Harbison:MBP1_H2O2HiParsons:HydroxyureaLum:Sodium Nitroprusside S000005234RFC3YNL290WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon &radic0.838451&radic&radic&radic S000003829RFC2YJR068WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon &radic0.841861&radic S000002633HTA1YDR225WverifiedOne of two nearly identical (see also HTA2) histone H2Asubtypes; core histone required for chromatinassembly and chromosome function; DNAdamage-dependent phosphorylation by Mec1pfacilitates DNA repair; acetylated by Nat4p &radic0.854441&radic&radic S000000213HHF1YBR009CverifiedOne of two identical histone H4 proteins (see also HHF2); corehistone required for chromatin assembly andchromosome function; contributes to telomericsilencing; N-terminal domain involved inmaintaining genomic integrity &radic0.813640.95238&radic S000005454RFC4YOL094CverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon &radic0.797170.93548&radic&radic&radic S000000119MCM2YBL023CverifiedProtein involved in DNA replication; component of the Mcm2-7hexameric complex that binds chromatin as apart of the pre-replicative complex &radic0.763360.93513&radic&radic&radic&radic&radic&radic&radic S000005206POL2YNL262WverifiedCatalytic subunit of DNA polymerase epsilon, one of the majorchromosomal DNA replication polymerasescharacterized by processivity and proofreadingexonuclease activity; also involved in DNAsynthesis during DNA repair &radic0.779440.93513&radic&radic&radic S000001927SMC2YFR031CverifiedComponent of the condensin complex, essential SMC chromosomalATPase family member that forms a complex withSmc4p to form the active ATPase; Smc2p/Smc4pcomplex binds DNA, possibly in the cleft formedby the coiled-coil of the folded dimer &radic0.781860.93513&radic S000000291RFC5YBR087WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon &radic0.750410.93227&radic S000001886SMC1YFL008WverifiedSubunit of the multiprotein cohesin complex, essential proteininvolved in chromosome segregation and indouble-strand DNA break repair; SMC chromosomalATPase family member, binds DNA with apreference for DNA with secondary structure &radic0.739460.93227&radic&radic&radic&radic&radic&radic&radic S000000415AME1YBR211CverifiedEssential kinetochore protein associated with microtubules andspindle pole bodies; component of thekinetochore sub-complex COMA (Ctf19p, Okp1p,Mcm21p, Ame1p); involved in spindle checkpointmaintenance &radic0.738380.93227&radic&radic S000000406CDC47YBR202WverifiedComponent of the hexameric MCM complex, which is important forpriming origins of DNA replication in G1 andbecomes an active ATP-dependent helicase thatpromotes DNA melting and elongation whenactivated by Cdc7p-Dbf4p in S-phase &radic0.703810.93061&radic&radic&radic&radic S000006223CDC54YPR019WverifiedEssential helicase component of heterohexameric MCM2-7complexes which bind pre-replication complexeson DNA and melt the DNA prior to replication;accumulates in the nucleus in G1; homolog of S.pombe Cdc21p &radic0.676690.93061&radic S000003169MCM6YGL201CverifiedProtein involved in DNA replication; component of the Mcm2-7hexameric complex that binds chromatin as apart of the pre-replicative complex &radic0.674720.93061&radic&radic S000006379DPB2YPR175WverifiedSecond largest subunit of DNA polymerase II (DNA polymeraseepsilon), required for normal yeast chromosomalreplication; expression peaks at the G1/S phaseboundary; potential Cdc28p substrate &radic0.681820.93061&radic&radic&radic&radic S000004373CTF3YLR381WverifiedOuter kinetochore protein that forms a complex with Mcm16p andMcm22p; may bind the kinetochore to spindlemicrotubules &radic0.721540.93061&radic&radic S000003610SMC3YJL074CverifiedSubunit of the multiprotein cohesin complex required for sisterchromatid cohesion in mitotic cells; alsorequired, with Rec8p, for cohesion andrecombination during meiosis; phylogeneticallyconserved SMC chromosomal ATPase family member &radic0.73350.93061&radic&radic&radic S000004076SMC4YLR086WverifiedSubunit of the condensin complex, which reorganizes chromosomesduring cell division, forms a stable complexwith Smc2p that has ATP-hydrolyzing andDNA-binding activity and promotes knotting ofcircular DNA; potential Cdc28p substrate &radic0.736070.93061&radic&radic&radic S000003896MCM22YJR135CverifiedProtein involved in minichromosome maintenance; component ofthe kinetochore; binds to centromeric DNA in aCtf19p-dependent manner &radic0.693050.93061&radic&radic&radic&radic S000005743RFC1YOR217WverifiedSubunit of heteropentameric Replication factor C (RF-C), whichis a DNA binding protein and ATPase that actsas a clamp loader of the proliferating cellnuclear antigen (PCNA) processivity factor forDNA polymerases delta and epsilon &radic0.700890.93061&radic&radic&radic S000004975HHF2YNL030WverifiedOne of two identical histone H4 proteins (see also HHF1); corehistone required for chromatin assembly andchromosome function; contributes to telomericsilencing; N-terminal domain involved inmaintaining genomic integrity &radic0.688220.93061&radic&radic S000005939CTF19YPL018WverifiedOuter kinetochore protein, required for accurate mitoticchromosome segregation; component of thekinetochore sub-complex COMA (Ctf19p, Okp1p,Mcm21p, Ame1p) that functions as a platform forkinetochore assembly &radic0.725130.93061&radic S000000214HHT1YBR010WverifiedOne of two identical histone H3 proteins (see also HHT2); corehistone required for chromatin assembly,involved in heterochromatin-mediated telomericand HM silencing; regulated by acetylation,methylation, and mitotic phosphorylation &radic0.698910.93061&radic&radic S000004264CDC46YLR274WverifiedComponent of the hexameric MCM complex, which is important forpriming origins of DNA replication in G1 andbecomes an active ATP-dependent helicase thatpromotes DNA melting and elongation whenactivated by Cdc7p-Dbf4p in S-phase &radic0.677660.93061&radic&radic S000002726MCM21YDR318WverifiedProtein involved in minichromosome maintenance; component ofthe COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p)that bridges kinetochore subunits that are incontact with centromeric DNA and the subunitsbound to microtubules &radic0.655530.92919&radic&radic&radic S000002662CHL4YDR254WverifiedOuter kinetochore protein required for chromosome stability,interacts with kinetochore proteins Ctf19p,Ctf3p, and Iml3p; exhibits a two-hybridinteraction with Mif2p; association with CENDNA requires Ctf19p &radic0.634370.92919&radic&radic S000002632HTB1YDR224CverifiedOne of two nearly identical (see HTB2) histone H2B subtypesrequired for chromatin assembly and chromosomefunction; Rad6p-Bre1p-Lge1p mediatedubiquitination regulates transcriptionalactivation, meiotic DSB formation and H3methylation &radic0.661620.92919&radic&radic&radic&radic&radic S000005372HTZ1YOL012CverifiedHistone variant H2AZ, exchanged for histone H2A in nucleosomesby the SWR1 complex; involved intranscriptional regulation through preventionof the spread of silent heterochromatin &radic0.654120.92919&radic&radic&radic&radic S000000311IML3YBR107CverifiedProtein with a role in kinetochore function, localizes to theouter kinetochore in a Ctf19p-dependent manner,interacts with Chl4p and Ctf19p &radic0.637410.92919&radic S000004976HHT2YNL031CverifiedOne of two identical histone H3 proteins (see also HHT1); corehistone required for chromatin assembly,involved in heterochromatin-mediated telomericand HM silencing; regulated by acetylation,methylation, and mitotic phosphorylation &radic0.630640.92919&radic&radic S000001745SPC34YKR037CverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; also localized tonuclear side of spindle pole body &radic0.623210.92874&radic&radic&radic&radic S000000758MCM3YEL032WverifiedProtein involved in DNA replication; component of the Mcm2-7hexameric complex that binds chromatin as apart of the pre-replicative complex &radic0.624980.92874&radic&radic S000000099HTA2YBL003CverifiedOne of two nearly identical (see also HTA1) histone H2Asubtypes; core histone required for chromatinassembly and chromosome function; DNAdamage-dependent phosphorylation by Mec1pfacilitates DNA repair; acetylated by Nat4p &radic0.573180.92803&radic&radic&radic&radic S000001791DAD2YKR083CverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; is transferred to thekinetochore prior to mitosis &radic0.596380.92803&radic&radic&radic&radic S000003411OKP1YGR179CverifiedOuter kinetochore protein, required for accurate mitoticchromosome segregation; component of thekinetochore sub-complex COMA (Ctf19p, Okp1p,Mcm21p, Ame1p) that functions as a platform forkinetochore assembly &radic0.583080.92803&radic&radic&radic S000001449DSN1YIR010WverifiedEssential component of the MIND kinetochore complex (Mtw1pIncluding Nnf1p-Nsl1p-Dsn1p) which joinskinetochore subunits contacting DNA to thosecontacting microtubules; important forchromosome segregation &radic0.579290.92803&radic S000002423DAD1YDR016CverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; is transferred to thekinetochore prior to mitosis &radic0.579560.92803&radic&radic S000000032MTW1YAL034W-AverifiedEssential component of the MIND kinetochore complex (Mtw1pIncluding Nnf1p-Nsl1p-Dsn1p) which joinskinetochore subunits contacting DNA to thosecontacting microtubules; critical tokinetochore assembly &radic0.572270.92803&radic S000005046POL1YNL102WverifiedCatalytic subunit of the DNA polymerase alpha-primase complex,required for the initiation of DNA replicationduring mitotic DNA synthesis and premeiotic DNAsynthesis &radic0.598560.92803&radic&radic&radic&radic&radic&radic S000001532CSE4YKL049CverifiedCentromere protein that resembles histones, required for properkinetochore function; homolog of human CENP-A &radic0.60040.92803&radic&radic S000002764SPC110YDR356WverifiedInner plaque spindle pole body (SPB) component, ortholog ofhuman kendrin; involved in connecting nuclearmicrotubules to SPB; interacts withTub4p-complex and calmodulin; phosphorylated byMps1p in cell cycle-dependent manner 0.563030.92375&radic&radic S000001535ASK1YKL052CverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; phosphorylated duringthe cell cycle by cyclin-dependent kinases &radic0.560450.92114&radic&radic&radic S000000820SPC25YER018CverifiedComponent of the evolutionarily conservedkinetochore-associated Ndc80 complex(Ndc80p-Nuf2p-Spc24p-Spc25p); involved inchromosome segregation, spindle checkpointactivity and kinetochore clustering &radic0.557190.91814&radic&radic&radic&radic S000001572MIF2YKL089WverifiedKinetochore protein with homology to human CENP-C, required forstructural integrity of the spindle duringanaphase spindle elongation, interacts withhistones H2A, H2B, and H4, phosphorylated byIpl1p &radic0.555780.9168&radic S000005430NUF2YOL069WverifiedComponent of the evolutionarily conservedkinetochore-associated Ndc80 complex(Ndc80p-Nuf2p-Spc24p-Spc25p); involved inchromosome segregation, spindle checkpointactivity and kinetochore clustering &radic0.555390.9168&radic&radic&radic S000002609SPC19YDR201WverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; also localized tonuclear side of spindle pole body &radic0.551360.9168&radic&radic&radic&radic S000004093CDC45YLR103CverifiedDNA replication initiation factor; recruited to MCM pre-RCcomplexes at replication origins; promotesrelease of MCM from Mcm10p, recruits elongationmachinery; mutants in human homolog may causevelocardiofacial and DiGeorge syndromes &radic0.553910.9168&radic&radic&radic S000003873NNF1YJR112WverifiedEssential component of the MIND kinetochore complex (Mtw1pIncluding Nnf1p-Nsl1p-Dsn1p) which joinskinetochore subunits contacting DNA to thosecontacting microtubules; required for accuratechromosome segregation &radic0.549890.91537&radic&radic S000002791NKP1YDR383CverifiedNon-essential kinetochore protein, subunit of the Ctf19 centralkinetochore complex(Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p) &radic0.549190.91357&radic&radic&radic&radic S000004683CTF18YMR078CverifiedSubunit of a complex with Ctf8p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion; may have overlappingfunctions with Rad24p in the DNA damagereplication checkpoint &radic0.541850.91181&radic&radic S000006154NSL1YPL233WverifiedEssential component of the MIND kinetochore complex (Mtw1pIncluding Nnf1p-Nsl1p-Dsn1p) which joinskinetochore subunits contacting DNA to thosecontacting microtubules; required for accuratechromosome segregation &radic0.546060.91181&radic&radic&radic S000005205ORC5YNL261WverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing &radic0.530470.90909&radic&radic&radic&radic&radic S000001406TID3YIL144WverifiedComponent of the evolutionarily conservedkinetochore-associated Ndc80 complex(Ndc80p-Nuf2p-Spc24p-Spc25p); conservedcoiled-coil protein involved in chromosomesegregation, spindle checkpoint activity,kinetochore assembly and clustering &radic0.527090.90909&radic S000003029DUO1YGL061CverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; is transferred to thekinetochore prior to mitosis &radic0.538720.90806&radic&radic&radic S000003061SPC105YGL093WverifiedProtein required for accurate chromosome segregation, localizesto the nuclear side of the spindle pole body;forms a complex with Ydr532cp 0.519550.90796&radic S000002161MCD1YDL003WverifiedEssential protein required for sister chromatid cohesion inmitosis and meiosis; subunit of the cohesincomplex; expression is cell cycle regulated andpeaks in S phase &radic0.513320.90651&radic&radic&radic S000005922HAT1YPL001WverifiedCatalytic subunit of the Hat1p-Hat2p histone acetyltransferasecomplex that uses the cofactor acetyl coenzymeA, to acetylate free nuclear and cytoplasmichistone H4; involved in telomeric silencing andDNA double-strand break repair 0.516120.90651&radic&radic S000004723SPC24YMR117CverifiedComponent of the evolutionarily conservedkinetochore-associated Ndc80 complex(Ndc80p-Nuf2p-Spc24p-Spc25p); involved inchromosome segregation, spindle checkpointactivity and kinetochore clustering &radic0.512880.90651 S000000098HTB2YBL002WverifiedOne of two nearly identical (see HTB1) histone H2B subtypesrequired for chromatin assembly and chromosomefunction; Rad6p-Bre1p-Lge1p mediatedubiquitination regulates transcriptionalactivation, meiotic DSB formation and H3methylation &radic0.493140.90436&radic&radic&radic S000000534BIK1YCL029CverifiedMicrotubule-associated protein, component of the interfacebetween microtubules and kinetochore, involvedin sister chromatid separation; essential inpolyploid cells but not in haploid or diploidcells; ortholog of mammalian CLIP-170 &radic0.490450.90219&radic&radic&radic&radic S000005194RAD50YNL250WverifiedSubunit of MRX complex, with Mre11p and Xrs2p, involved inprocessing double-strand DNA breaks invegetative cells, initiation of meiotic DSBs,telomere maintenance, and nonhomologous endjoining 0.477460.89269&radic&radic S000003372CBF2YGR140WverifiedEssential kinetochore protein, component of the CBF3multisubunit complex that binds to the CDEIIIregion of the centromere; Cbf2p also binds tothe CDEII region possibly forming a differentmultimeric complex, ubiquitinated in vivo &radic0.476530.89262&radic&radic&radic&radic&radic S000000482DPB3YBR278WverifiedThird-largest subunit of DNA polymerase II (DNA polymeraseepsilon), required to maintain fidelity ofchromosomal replication and also forinheritance of telomeric silencing; mRNAabundance peaks at the G1/S boundary of thecell cycle &radic0.467490.8893&radic&radic S000004035STU2YLR045CverifiedMicrotubule-associated protein (MAP) of the XMAP215/Dis1family; regulates microtubule dynamics duringspindle orientation and metaphase chromosomealignment; interacts with spindle pole bodycomponent Spc72p &radic0.465890.88906&radic&radic&radic&radic S000002528DPB4YDR121WverifiedShared subunit of DNA polymerase epsilon and of ISW2/yCHRACchromatin accessibility complex; involved inboth chromosomal DNA replication and ininheritance of telomeric silencing &radic0.464170.88877&radic&radic&radic&radic&radic S000000131POL12YBL035CverifiedB subunit of DNA polymerase alpha-primase complex, required forinitiation of DNA replication during mitoticand premeiotic DNA synthesis; also functions intelomere capping and length regulation &radic0.451030.88381&radic&radic&radic&radic&radic S000005770ESA1YOR244WverifiedHistone acetyltransferase catalytic subunit of the nativemultisubunit complex (NuA4) that acetylatesfour conserved internal lysines of histone H4N-terminal tail; required for cell cycleprogression 0.452110.88381&radic&radic S000006190KAR9YPL269WverifiedKaryogamy protein required for correct positioning of themitotic spindle and for orienting cytoplasmicmicrotubules, localizes at the shmoo tip inmating cells and at the tip of the growing budin small-budded cells through anaphase 0.446240.88085&radic&radic&radic S000000912KAP123YER110CverifiedKaryopherin beta, mediates nuclear import of ribosomal proteinsprior to assembly into ribosomes and import ofhistones H3 and H4; localizes to the nuclearpore, nucleus, and cytoplasm; exhibits geneticinteractions with RAI1 0.446220.88085&radic&radic&radic S000004307NKP2YLR315WverifiedNon-essential kinetochore protein, subunit of the Ctf19 centralkinetochore complex(Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p) &radic0.440630.87506&radic&radic S000005394SMC5YOL034WverifiedStructural maintenance of chromosomes (SMC) protein; essentialsubunit of the Mms21-Smc5-Smc6 complex;required for growth and DNA repair; S. pombehomolog forms a heterodimer with S. pombeRad18p that is involved in DNA repair &radic0.43940.87506&radic&radic&radic S000007604DAD4YDR320C-AverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; is transferred to thekinetochore prior to mitosis &radic0.440420.87506 S000003043MPS2YGL075CverifiedEssential membrane protein localized at the nuclear envelopeand spindle pole body (SPB), required forinsertion of the newly duplicated SPB into thenuclear envelope; potentially phosphorylated byCdc28p 0.441220.87506&radic&radic&radic&radic S000001447PRI1YIR008CverifiedSubunit of DNA primase, which is required for DNA synthesis anddouble-strand break repair &radic0.437090.87306 S000001288IRR1YIL026CverifiedSubunit of the cohesin complex, which is required for sisterchromatid cohesion during mitosis and meiosisand interacts with centromeres and chromosomearms, essential for viability &radic0.433690.87014&radic&radic&radic&radic&radic&radic&radic S000006076KIP2YPL155CverifiedKinesin-related motor protein involved in mitotic spindlepositioning, stabilizes microtubules bytargeting Bik1p to the plus end; Kip2p levelsare controlled during the cell cycle 0.42940.86638&radic S000000288MIS1YBR084WverifiedMitochondrial C1-tetrahydrofolate synthase, involved ininterconversion between different oxidationstates of tetrahydrofolate (THF); providesactivities of formyl-THF synthetase,methenyl-THF cyclohydrolase, and methylene-THFdehydrogenase 0.414390.85639 S000004593TUB3YML124CverifiedAlpha-tubulin; associates with beta-tubulin (Tub2p) to formtubulin dimer, which polymerizes to formmicrotubules; expressed at lower level thanTub1p 0.410580.85159&radic&radic S000001525SPC42YKL042WverifiedCentral plaque component of spindle pole body (SPB); involvedin SPB duplication, may facilitate attachmentof the SPB to the nuclear membrane 0.404330.84602&radic&radic&radic&radic S000003556MPS3YJL019WverifiedEssential integral membrane protein required for spindle polebody duplication and for nuclear fusion,localizes to the spindle pole body half bridge,interacts with DnaJ-like chaperone Jem1p andwith centrin homolog Cdc31p 0.402470.84515&radic S000005721SLK19YOR195WverifiedKinetochore-associated protein required for normal segregationof chromosomes in meiosis and mitosis;component of the FEAR regulatory network, whichpromotes Cdc14p release from the nucleolusduring anaphase; potential Cdc28p substrate &radic0.394150.83654&radic&radic S000002216USO1YDL058WverifiedEssential protein involved in intracellular protein transport,coiled-coil protein necessary for transportfrom ER to Golgi; required for assembly of theER-to-Golgi SNARE complex 0.392860.83627&radic&radic S000004375SMC6YLR383WverifiedProtein involved in structural maintenance of chromosomes;essential subunit of Mms21-Smc5-Smc6 complex;required for growth, DNA repair,interchromosomal and sister chromatidrecombination; homologous to S. pombe rad18 &radic0.391470.83419&radic S000005032TOP2YNL088WverifiedEssential type II topoisomerase, relieves torsional strain inDNA by cleaving and re-sealing thephosphodiester backbone of both positively andnegatively supercoiled DNA; cleavescomplementary strands; localizes to axial coresin meiosis &radic0.379040.82274&radic&radic S000000264ORC2YBR060CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing; may be phosphorylated by Cdc28p &radic0.380170.82274&radic&radic S000000072CDC15YAR019CverifiedProtein kinase of the Mitotic Exit Network that is localized tothe spindle pole bodies at late anaphase;promotes mitotic exit by directly switching onthe kinase activity of Dbf2p 0.369770.81764&radic S000003849BIR1YJR089WverifiedEssential chromosomal passenger protein involved incoordinating cell cycle events for properchromosome segregation; C-terminal region bindsSli15p, and the middle region, uponphosphorylation, localizes Cbf2p to the spindleat anaphase &radic0.367360.81496&radic&radic&radic S000004550TUB1YML085CverifiedAlpha-tubulin; associates with beta-tubulin (Tub2p) to formtubulin dimer, which polymerizes to formmicrotubules 0.365430.81318&radic S000005364SIN3YOL004WverifiedComponent of the Sin3p-Rpd3p histone deacetylase complex,involved in transcriptional repression andactivation of diverse processes, includingmating-type switching and meiosis; involved inthe maintenance of chromosomal integrity 0.360790.81078&radic&radic&radic S000005274RPD3YNL330CverifiedHistone deacetylase; regulates transcription and silencing 0.358840.80928&radic&radic&radic S000000130STU1YBL034CverifiedComponent of the mitotic spindle that binds to interpolarmicrotubules via its association withbeta-tubulin (Tub2p); required for interpolarmicrotubules to provide an outward force on thespindle poles 0.356970.80829&radic&radic&radic&radic S000006345KAR3YPR141CverifiedMinus-end-directed microtubule motor that functions in mitosisand meiosis, localizes to the spindle pole bodyand localization is dependent on functionalCik1p, required for nuclear fusion duringmating; potential Cdc28p substrate 0.350170.80238&radic&radic&radic&radic S000005885HAP5YOR358WverifiedSubunit of the heme-activated, glucose-repressed Hap2/3/4/5CCAAT-binding complex, a transcriptionalactivator and global regulator of respiratorygene expression; required for assembly and DNAbinding activity of the complex 0.34720.8002&radic&radic&radic&radic S000001234CTF8YHR191CverifiedSubunit of a complex with Ctf18p that shares some subunits withReplication Factor C and is required for sisterchromatid cohesion &radic0.339140.79452&radic S000006366ORC4YPR162CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing &radic0.338850.79452&radic&radic&radic&radic S000004530ORC1YML065WverifiedLargest subunit of the origin recognition complex, whichdirects DNA replication by binding toreplication origins and is also involved intranscriptional silencing; may bephosphorylated by Cdc28p &radic0.334060.79234&radic&radic&radic S000000045SPC72YAL047CverifiedComponent of the cytoplasmic Tub4p (gamma-tubulin) complex,binds spindle pole bodies and links them tomicrotubules; has roles in astral microtubuleformation and stabilization 0.332060.79234 S000003420BUB1YGR188CverifiedProtein kinase that forms a complex with Mad1p and Bub3p thatis crucial in the checkpoint mechanism requiredto prevent cell cycle progression into anaphasein the presence of spindle damage, associateswith centromere DNA via Skp1p &radic0.333360.79234&radic&radic S000005256RFA2YNL312WverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination &radic0.33170.79195&radic&radic&radic&radic S000004659BUB2YMR055CverifiedMitotic exit network regulator, forms GTPase-activatingBfa1p-Bub2p complex that binds Tem1p andspindle pole bodies, blocks cell cycleprogression before anaphase in response tospindle and kinetochore damage 0.33070.79094&radic S000001215SPC97YHR172WverifiedComponent of the microtubule-nucleating Tub4p (gamma-tubulin)complex; interacts with Spc110p at the spindlepole body (SPB) inner plaque and with Spc72p atthe SPB outer plaque 0.327330.78661&radic&radic&radic&radic S000001528PRI2YKL045WverifiedSubunit of DNA primase, which is required for DNA synthesis anddouble-strand break repair &radic0.327330.78661&radic&radic S000000787CIN8YEL061CverifiedKinesin motor protein involved in mitotic spindle assembly andchromosome segregation &radic0.324790.78578&radic&radic&radic S000003927ORC3YLL004WverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing &radic0.321580.78358&radic&radic&radic&radic&radic S000002817SIZ1YDR409WverifiedSUMO ligase that promotes the attachment of sumo (Smt3p; smallubiquitin-related modifier) to proteins; bindsUbc9p and may bind septins; specificallyrequired for sumoylation of septins in vivo;localized to the septin ring &radic0.317920.78072&radic&radic&radic S000000065RFA1YAR007CverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination &radic0.3170.78071&radic&radic&radic&radic S000005169CNM67YNL225CverifiedComponent of the spindle pole body outer plaque; required forspindle orientation and mitotic nuclearmigration 0.315780.77924&radic&radic&radic S000002160NHP10YDL002CverifiedProtein related to mammalian high mobility group proteins;likely component of the INO80 complex, which isan ATP-dependent chromatin-remodeling complex 0.315530.77924&radic&radic&radic S000003814BFA1YJR053WverifiedComponent of the GTPase-activating Bfa1p-Bub2p complex involvedin multiple cell cycle checkpoint pathways thatcontrol exit from mitosis 0.311250.77666&radic S000006130IPL1YPL209CverifiedAurora kinase involved in regulating kinetochore-microtubuleattachments; helps maintain condensedchromosomes during anaphase and earlytelophase; associates with Sli15p, whichpromotes Ipl1p association with mitotic spindle &radic0.305430.77332&radic&radic&radic&radic S000001160ORC6YHR118CverifiedSubunit of the origin recognition complex, which directs DNAreplication by binding to replication originsand is also involved in transcriptionalsilencing; may be phosphorylated by Cdc28p &radic0.301260.77061&radic&radic&radic&radic&radic S000002260CDC2YDL102WverifiedCatalytic subunit of DNA polymerase delta; required forchromosomal DNA replication during mitosis andmeiosis, intragenic recombination, repair ofdouble strand DNA breaks, and DNA replicationduring nucleotide excision repair (NER) &radic0.301150.77061&radic&radic S000002578HSP42YDR171WverifiedSmall cytosolic stress-induced chaperone that formsbarrel-shaped oligomers and suppresses theaggregation of non-native proteins; oligomerdissociation is not required for function;involved in cytoskeleton reorganization afterheat shock 0.300070.76911&radic&radic&radic&radic S000003335NOP7YGR103WverifiedNucleolar protein involved in rRNA processing and 60S ribosomalsubunit biogenesis; constituent of severaldifferent pre-ribosomal particles; required forexit from G0 and the initiation ofcell proliferation 0.298830.76631&radic&radic&radic&radic S000006045SPC29YPL124WverifiedInner plaque spindle pole body (SPB) component, links thecentral plaque component Spc42p to the innerplaque component Spc110p; required for SPBduplication 0.29630.76299&radic&radic&radic&radic&radic S000004529TEM1YML064CverifiedGTP-binding protein of the ras superfamily involved intermination of M-phase; controls actomyosin andseptin dynamics during cytokinesis 0.28610.75569 S000007595DAD3YBR233W-AverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; is transferred to thekinetochore prior to mitosis &radic0.284050.75454 S000003184KIP3YGL216WverifiedKinesin-related motor protein involved in mitotic spindlepositioning 0.282990.75198&radic&radic&radic S000002344TFP1YDL185WverifiedVacuolar ATPase V1 domain subunit A containing the catalyticnucleotide binding sites; protein precursorundergoes self-catalyzed splicing to yield theextein Tfp1p and the intein Vde (PI-SceI),which is a site-specific endonuclease 0.270530.73699&radic&radic S000006088REV3YPL167CverifiedCatalytic subunit of DNA polymerase zeta, which is involved inDNA repair and translesion synthesis; requiredfor mutagenesis induced by DNA damage 0.267710.73262&radic&radic S000000865THO1YER063WverifiedProtein of unknown function; overproduction suppresses thetranscriptional defect caused by an hpr1mutation 0.267240.7324&radic&radic S000002835RPN9YDR427WverifiedNon-ATPase regulatory subunit of the 26S proteasome, hassimilarity to putative proteasomal subunits inother species; null mutant is temperaturesensitive and exhibits cell cycle andproteasome assembly defects 0.266040.7303&radic&radic&radic S000005682NFI1YOR156CverifiedSUMO ligase, catalyzes the covalent attachment of SUMO (Smt3p)to proteins; involved in maintenance of propertelomere length &radic0.265250.72905&radic&radic&radic&radic&radic S000004793YMR181CUncharacterizedProtein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene 0.264390.72709&radic S000003963VPS13YLL040CverifiedProtein of unknown function; heterooligomeric or homooligomericcomplex; peripherally associated withmembranes; homologous to human COH1; involvedin sporulation, vacuolar protein sorting andprotein-Golgi retention 0.262890.72564&radic&radic S000004778CEP3YMR168CverifiedEssential kinetochore protein, component of the CBF3 complexthat binds the CDEIII region of the centromere;contains an N-terminal Zn2Cys6 type zinc fingerdomain, a C-terminal acidic domain, and aputative coiled coil dimerization domain &radic0.261880.72481&radic&radic S000005599SGO1YOR073WverifiedComponent of the spindle checkpoint, involved in sensing lackof tension on mitotic chromosomes; protectscentromeric Rec8p at meiosis I; required foraccurate chromosomal segregation at meiosis IIand for mitotic chromosome stability &radic0.259540.72357&radic&radic&radic S000000229YBR025CUncharacterizedHypothetical protein 0.259350.7231&radic&radic S000004925PSE1YMR308CverifiedKaryopherin/importin that interacts with the nuclear porecomplex; acts as the nuclear import receptorfor specific proteins, including Pdr1p, Yap1p,Ste12p, and Aft1p 0.258420.7212&radic&radic S000001368MOB1YIL106WverifiedComponent of the mitotic exit network; associates with and isrequired for the activation andCdc15p-dependent phosphorylation of the Dbf2pkinase; required for cytokinesis and cellseparation; component of the CCR4transcriptional complex 0.255050.71763&radic&radic S000004676ABF2YMR072WverifiedMitochondrial DNA-binding protein involved in mitochondrial DNAreplication and recombination, member of HMG1DNA-binding protein family; activity may beregulated by protein kinase A phosphorylation 0.253350.71662 S000000949SCC4YER147CverifiedSubunit of cohesin loading factor (Scc2p-Scc4p), a complexrequired for the loading of cohesin complexesonto chromosomes; involved in establishingsister chromatid cohesion during double-strandbreak repair via phosphorylated histone H2AX &radic0.250610.71629&radic S000003730CDC6YJL194WverifiedEssential ATP-binding protein required for DNA replication,component of the pre-replicative complex(pre-RC) which requires ORC to associate withchromatin and is in turn required for Mcm2-7pDNA association; homologous to S. pombe Cdc18p 0.252720.71629&radic&radic&radic&radic S000004200CLB4YLR210WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the G2/M transition; may beinvolved in DNA replication and spindleassembly; accumulates during S phase and G2,then targeted for ubiquitin-mediateddegradation 0.24280.70567&radic&radic&radic S000003766HYS2YJR006WverifiedDNA polymerase III (delta) subunit, essential for cellviability; involved in DNA replication and DNArepair &radic0.238570.69962&radic S000002940YDR532CUncharacterizedProtein of unknown function that localizes to the nuclear side of the spindle pole body and along short spindles; deletion mutants have short telomeres; forms a complex with Spc105p 0.237350.69647 S000004811CIK1YMR198WverifiedKinesin-associated protein required for both karyogamy andmitotic spindle organization, interacts stablyand specifically with Kar3p and may function totarget this kinesin to a specific cellularrole; has similarity to Vik1p 0.236950.69647&radic S000003651ASF1YJL115WverifiedNucleosome assembly factor, involved in chromatin assembly anddisassembly, anti-silencing protein that causesderepression of silent loci when overexpressed 0.236670.69598&radic&radic&radic&radic S000005070SPC98YNL126WverifiedComponent of the microtubule-nucleating Tub4p (gamma-tubulin)complex; interacts with Spc110p at the spindlepole body (SPB) inner plaque and with Spc72p atthe SPB outer plaque 0.235180.69494 S000005584ASE1YOR058CverifiedMember of a family of microtubule-associated proteins (MAPs)that function at the mitotic spindle midzone;required for spindle elongation; undergoes cellcycle-regulated degradation by anaphasepromoting complex; potential Cdc28p substrate 0.233520.69404&radic&radic S000000818BIM1YER016WverifiedMicrotubule-binding protein that together with Kar9p makes upthe cortical microtubule capture site anddelays the exit from mitosis when the spindleis oriented abnormally &radic0.229170.68809&radic&radic&radic&radic S000003084CDC20YGL116WverifiedCell-cycle regulated activator of anaphase-promotingcomplex/cyclosome (APC/C), which is requiredfor metaphase/anaphase transition; directsubiquitination of mitotic cyclins, Pds1p, andother anaphase inhibitors; potential Cdc28psubstrate 0.222120.67892&radic&radic S000004391BDF1YLR399CverifiedProtein involved in transcription initiation at TATA-containingpromoters; associates with the basaltranscription factor TFIID; contains twobromodomains; corresponds to the C-terminalregion of mammalian TAF1; redundant with Bdf2p &radic0.22040.67705&radic&radic&radic&radic&radic&radic S000002718SUM1YDR310CverifiedTranscriptional repressor required for mitotic repression ofmiddle sporulation-specific genes; involved intelomere maintenance, regulated by thepachytene checkpoint 0.216420.6698&radic&radic S000002157NHP6BYBR089C-AverifiedHigh-mobility group non-histone chromatin protein, functionallyredundant with Nhp6Ap; homologous to mammalianhigh mobility group proteins 1 and 2; acts torecruit transcription factor Rcs1p to certainpromoters &radic0.212710.66281&radic&radic S000001412MCM10YIL150CverifiedEssential, chromatin-associated protein involved in theinitiation of DNA replication; required for theassociation of the MCM2-7 complex withreplication origins 0.210910.66182&radic&radic S000000148SAS3YBL052CverifiedHistone acetyltransferase catalytic subunit of NuA3 complexthat acetylates histone H3, involved intranscriptional silencing; homolog of themammalian MOZ proto-oncogene; sas3 gcn5 doublemutation confers lethality &radic0.206440.65654&radic&radic&radic S000003484GCN5YGR252WverifiedHistone acetyltransferase, acetylates N-terminal lysines onhistones H2B and H3; catalytic subunit of theADA and SAGA histone acetyltransferasecomplexes; founding member of the Gcn5p-relatedN-acetyltransferase superfamily 0.206640.65653&radic&radic S000001401REV7YIL139CverifiedProcessivity subunit of DNA polymerase zeta, which is involvedin DNA repair and translesion synthesis;required for mutagenesis induced by DNA damage 0.206770.65653&radic S000000360SLI15YBR156CverifiedSubunit of the Ipl1p-Sli15p-Bir1p complex that regulateskinetochore-microtubule attachments, activationof the spindle tension checkpoint, and mitoticspindle disassembly; regulates the activity andlocalization of the Ipl1p aurora kinase 0.203380.65224&radic&radic S000002330GLT1YDL171CverifiedNAD(+)-dependent glutamate synthase (GOGAT), synthesizesglutamate from glutamine andalpha-ketoglutarate; with Gln1p, forms thesecondary pathway for glutamate biosynthesisfrom ammonia; expression regulated by nitrogensource 0.203110.65141&radic S000003098CEG1YGL130WverifiedAlpha (guanylyltransferase) subunit of the mRNA capping enzyme,a heterodimer (the other subunit is CET1, anRNA 5'-triphophatase) involved in adding the 5'cap to mRNA; the mammalian enzyme is a singlebifunctional polypeptide 0.202580.65019&radic&radic S000000745MMS21YEL019CverifiedSUMO ligase involved in chromosomal organization and DNArepair; essential subunit of theMms21-Smc5-Smc6 complex; mutants are sensitiveto methyl methanesulfonate and show increasedspontaneous mutation and mitotic recombination &radic0.201260.64839&radic&radic&radic&radic&radic S000000975RAD24YER173WverifiedCheckpoint protein, involved in the activation of the DNAdamage and meiotic pachytene checkpoints;subunit of a clamp loader that loadsRad17p-Mec3p-Ddc1p onto DNA; homolog of humanand S. pombe Rad17 protein &radic0.199820.64551&radic&radic&radic S000001356LYS12YIL094CverifiedHomo-isocitrate dehydrogenase, an NAD-linked mitochondrialenzyme required for the fourth step in thebiosynthesis of lysine, in whichhomo-isocitrate is oxidatively decarboxylatedto alpha-ketoadipate 0.19890.64498 S000002969ERG26YGL001CverifiedC-3 sterol dehydrogenase, catalyzes the second of three stepsrequired to remove two C-4 methyl groups froman intermediate in ergosterol biosynthesis 0.190970.632&radic&radic S000005667ARP8YOR141CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes 0.190480.63145&radic&radic&radic S000005670ELG1YOR144CverifiedProtein required for S phase progression and telomerehomeostasis, forms an alternative replicationfactor C complex important for DNA replicationand genome integrity; involved in homologousrecombination-mediated DNA repair &radic0.190390.63145&radic&radic&radic S000001596RAD27YKL113Cverified5' to 3' exonuclease, 5' flap endonuclease, required forOkazaki fragment processing and maturation aswell as for long-patch base-excision repair;member of the S. pombe RAD2/FEN1 family 0.190170.63127&radic&radic&radic&radic S000002742SWR1YDR334WverifiedSwi2/Snf2-related ATPase that is the structural component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.188870.62786&radic&radic&radic&radic&radic&radic&radic S000004734SAS2YMR127CverifiedHistone acetyltransferase (HAT) catalytic subunit of the SAScomplex (Sas2p-Sas4p-Sas5p), which acetylatesfree histones and nucleosomes and regulatestranscriptional silencing; member of theMYSTacetyltransferase family &radic0.18450.62181&radic&radic&radic S000006250MCM16YPR046WverifiedProtein involved in kinetochore-microtubule mediated chromosomesegregation; binds to centromere DNA &radic0.184830.62181&radic S000000897RAD51YER095WverifiedStrand exchange protein, forms a helical filament with DNA thatsearches for homology; involved in therecombinational repair of double-strand breaksin DNA during vegetative growth and meiosis;homolog of Dmc1p and bacterial RecA protein 0.181960.61824&radic&radic&radic S000003926SFI1YLL003WverifiedCentrin (Cdc31p)-binding protein required for spindle pole body(SPB) duplication, localizes to the half-bridgeof the SPB, required for progression throughG(2)-M transition, has similarity to Xenopuslaevis XCAP-C 0.181220.61539&radic&radic&radic S000004494RAD52YML032CverifiedProtein that stimulates strand exchange by facilitating Rad51pbinding to single-stranded DNA; annealscomplementary single-stranded DNA; involved inthe repair of double-strand breaks in DNAduring vegetative growth and meiosis 0.181880.61539&radic&radic&radic S000006308FHL1YPR104CverifiedPutative transcriptional regulator with similarity toDNA-binding domain of Drosophila forkhead;required for rRNA processing 0.181940.61539&radic&radic S000006256NHP6AYPR052CverifiedHigh-mobility group non-histone chromatin protein, functionallyredundant with Nhp6Bp; homologous to mammalianhigh mobility group proteins 1 and 2; acts torecruit transcription factor Rcs1p to certainpromoters &radic0.179810.6133&radic&radic&radic S000001197RTT107YHR154WverifiedProtein implicated in Mms22-dependent DNA repair during Sphase, DNA damage induces phosphorylation byMec1p at one or more SQ/TQ motifs; interactswith Mms22p and Slx4p; has four BRCT domains;has a role in regulation of Ty1 transposition 0.179810.6133&radic&radic&radic&radic S000002625RAD9YDR217CverifiedDNA damage-dependent checkpoint protein, required forcell-cycle arrest in G1/S, intra-S, and G2/M;transmits checkpoint signal by activatingRad53p and Chk1p; hyperphosphorylated by Mec1pand Tel1p; potential Cdc28p substrate 0.178780.61052&radic&radic&radic&radic&radic S000002588SCC2YDR180WverifiedSubunit of cohesin loading factor (Scc2p-Scc4p), a complexrequired for the loading of cohesin complexesonto chromosomes; involved in establishingsister chromatid cohesion during DSB repair viahistone H2AX &radic0.17690.60587&radic&radic&radic&radic&radic S000002504MSH6YDR097CverifiedProtein required for mismatch repair in mitosis and meiosis,forms a complex with Msh2p to repair bothsingle-base & insertion-deletion mispairs;potentially phosphorylated by Cdc28p 0.174340.60171&radic&radic&radic S000002733YCG1YDR325WverifiedNon-SMC subunit of the condensin complex(Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required forestablishment and maintenance of chromosomecondensation, chromosome segregation and forchromatin binding of the condensin complex &radic0.173890.60105&radic&radic S000003210KAP114YGL241WverifiedKaryopherin, responsible for nuclear import of Spt15p, histonesH2A and H2B, and Nap1p; amino terminus showssimilarity to those of other importins,particularly Cse1p; localization is primarilynuclear 0.173580.60021&radic&radic&radic&radic S000004534POB3YML069WverifiedSubunit of the heterodimeric FACT complex (Spt16p-Pob3p), whichfacilitates RNA Polymerase II transcriptionelongation through nucleosomes by destabilizingand then reassembling nucleosome structure &radic0.173020.59938&radic&radic&radic S000003288RSC1YGR056WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; containstwo essential bromodomains, a bromo-adjacenthomology (BAH) domain, and an AT hook 0.171330.59672&radic&radic&radic&radic S000006003MOT1YPL082CverifiedEssential abundant protein involved in regulation oftranscription, removes Spt15p (TBP) from DNAvia its C-terminal ATPase activity, forms acomplex with TBP that binds TATA DNA with highaffinity but with altered specificity 0.170470.59552&radic&radic&radic&radic S000000193BRN1YBL097WverifiedEssential protein required for chromosome condensation, likelyto function as an intrinsic component of thecondensation machinery, may influence multipleaspects of chromosome transmission and dynamics &radic0.170110.59394&radic&radic S000002581HMO1YDR174WverifiedChromatin associated high mobility group (HMG) family memberinvolved in genome maintenance; rDNA-bindingcomponent of the Pol I transcription system;associates with a 5'-3' DNA helicase and Fpr1p,a prolyl isomerase &radic0.167820.59069&radic S000006074RAD53YPL153CverifiedProtein kinase, required for cell-cycle arrest in response toDNA damage; activated by transautophosphorylation when interacting withhyperphosphorylated Rad9p; also interacts withARS1 and plays a role in initiation of DNAreplication 0.167550.59014&radic&radic&radic&radic S000004349RSC2YLR357WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; required for expression ofmid-late sporulation-specific genes; involvedin telomere maintenance 0.167360.58933&radic&radic&radic&radic S000001515IXR1YKL032CverifiedProtein that binds DNA containing intrastrand cross-linksformed by cisplatin, contains two HMG (highmobility group box) domains, which confer theability to bend cisplatin-modified DNA;mediates aerobic transcriptional repression ofCOX5b 0.1670.58787&radic&radic&radic S000000521DCC1YCL016CverifiedSubunit of a complex with Ctf8p and Ctf18p that shares somecomponents with Replication Factor C, requiredfor sister chromatid cohesion and telomerelength maintenance &radic0.166920.58724&radic&radic&radic&radic S000005160RAP1YNL216WverifiedDNA-binding protein involved in either activation or repressionof transcription, depending on binding sitecontext; also binds telomere sequences andplays a role in telomeric position effect(silencing) and telomere structure &radic0.163840.58188&radic&radic&radic S000000292POL30YBR088CverifiedProliferating cell nuclear antigen (PCNA), functions as thesliding clamp for DNA polymerase delta; mayfunction as a docking site for other proteinsrequired for mitotic and meiotic chromosomalDNA replication and for DNA repair &radic0.163330.58067&radic&radic&radic S000005217TOF1YNL273WverifiedSubunit of a replication-pausing checkpoint complex(Tof1p-Mrc1p-Csm3p) that acts at the stalledreplication fork to promote sister chromatidcohesion after DNA damage, facilitating gaprepair of damaged DNA; interacts with the MCMhelicase 0.162640.58021&radic&radic&radic&radic S000004262YCS4YLR272CverifiedNon-SMC subunit of the condensin complex(Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required forestablishment and maintenance of chromosomecondensation, chromosome segregation, chromatinbinding of condensin and silencing at themating type locus &radic0.161930.5796&radic&radic&radic&radic S000003175SPT16YGL207WverifiedSubunit of the heterodimeric FACT complex (Spt16p-Pob3p),facilitates RNA Polymerase II transcriptionelongation through nucleosomes by destabilizingand then reassembling nucleosome structure &radic0.161060.57815&radic&radic&radic&radic&radic S000005051YAF9YNL107WverifiedSubunit of both the NuA4 histone H4 acetyltransferase complexand the SWR1 complex, may function toantagonize silencing near telomeres; interactsdirectly with Swc4p, has homology to humanleukemogenic protein AF9, contains a YEATSdomain 0.160770.57655&radic&radic&radic S000002598RVB1YDR190CverifiedEssential protein involved in transcription regulation;component of chromatin remodeling complexes;required for assembly and function of the INO80complex; member of the RUVB-like protein family 0.159990.57645&radic&radic&radic S000005150RTT106YNL206CverifiedProtein with a role in regulation of Ty1 transposition 0.158680.57402&radic&radic&radic&radic S000005816SNF2YOR290CverifiedCatalytic subunit of the SWI/SNF chromatin remodeling complexinvolved in transcriptional regulation;contains DNA-stimulated ATPase activity;functions interdependently in transcriptionalactivation with Snf5p and Snf6p 0.157460.57215&radic&radic&radic&radic&radic S000003348SPT6YGR116WverifiedEssential protein that interacts with histones and is involvedin nucleosome disassembly and reassembly duringtranscription elongation 0.157410.57215&radic&radic&radic S000002175CDC7YDL017WverifiedDDK (Dbf4-dependent kinase) catalytic subunit required forfiring origins and replication fork progressionin mitosis through phosphorylation of Mcm2-7pcomplexes and Cdc45p; kinase activitycorrelates with cyclical DBF4 expression 0.155490.56916&radic&radic&radic&radic&radic S000002553SWI5YDR146CverifiedTranscription factor that activates transcription of genesexpressed at the M/G1 phase boundary and in G1phase; localization to the nucleus occursduring G1 and appears to be regulated byphosphorylation by Cdc28p kinase 0.154730.56788&radic&radic&radic S000003494BUD32YGR262CverifiedProtein kinase proposed to be involved in bud-site selection,telomere uncapping and elongation, andtranscription; component of the EKC/KEOPSprotein complex with Kae1p, Cgi121p, Pcc1p, andGon7p 0.152760.5636&radic&radic&radic S000001597APN1YKL114CverifiedMajor apurinic/apyrimidinic endonuclease, 3'-repair diesteraseinvolved in repair of DNA damage by oxidationand alkylating agents; also functions as a3'-5' exonuclease to repair7,8-dihydro-8-oxodeoxyguanosine 0.151240.55966&radic&radic&radic&radic&radic&radic S000004166RFX1YLR176CverifiedProtein involved in DNA damage and replication checkpointpathway; recruits repressors Tup1p and Cyc8p topromoters of DNA damage-inducible genes;similar to a family of mammalian DNA bindingRFX1-4 proteins 0.151040.55966&radic&radic&radic&radic&radic&radic S000004890FCP1YMR277WverifiedCarboxy-terminal domain (CTD) phosphatase, essential fordephosphorylation of the repeated C-terminaldomain of the RNA polymerase II large subunit(Rpo21p) 0.150720.55917&radic&radic&radic S000005873REV1YOR346WverifiedDeoxycytidyl transferase, forms a complex with the subunits ofDNA polymerase zeta, Rev3p and Rev7p; involvedin repair of abasic sites in damaged DNA 0.150470.55899&radic&radic&radic S000001622CTK1YKL139WverifiedCatalytic (alpha) subunit of C-terminal domain kinase I(CTDK-I), which phosphorylates the C-terminalrepeated domain of the RNA polymerase II largesubunit (Rpo21p) to affect both transcriptionand pre-mRNA 3' end processing 0.149820.5571&radic&radic&radic S000002259DUN1YDL101CverifiedCell-cycle checkpoint serine-threonine kinase required for DNAdamage-induced transcription of certain targetgenes, phosphorylation of Rad55p and Sml1p, andtransient G2/M arrest after DNA damage; alsoregulates postreplicative DNA repair 0.149410.55634&radic&radic&radic&radic&radic S000004202TUB4YLR212CverifiedGamma-tubulin, involved in nucleating microtubules from boththe cytoplasmic and nuclear faces of thespindle pole body 0.149290.55591&radic&radic S000006176BBP1YPL255WverifiedProtein required for the spindle pole body (SPB) duplication,localized at the central plaque periphery;forms a complex with a nuclear envelope proteinMps2p and SPB components Spc29p and Kar1p;required for mitotic functions of Cdc5p 0.149020.55537&radic S000003813RAD7YJR052WverifiedProtein that recognizes and binds damaged DNA in anATP-dependent manner (with Rad16p) duringnucleotide excision repair; subunit ofNucleotide Excision Repair Factor 4 (NEF4) 0.147230.55152&radic&radic S000002736SKP1YDR328CverifiedEvolutionarily conserved kinetochore protein that is part ofmultiple protein complexes, including the SCFubiquitin ligase complex, the CBF3 complex thatbinds centromeric DNA, and the RAVE complexthat regulates assembly of the V-ATPase &radic0.147090.5512&radic&radic&radic&radic S000001388STH1YIL126WverifiedATPase component of the ATP-dependent RSC chromatin remodelingcomplex required for kinetochore function inchromosome segregation; required for expressionof early meiotic genes; essentialhelicase-related protein homologous to Snf2p 0.146750.54976&radic&radic S000003626DPB11YJL090CverifiedEssential BRCT repeat protein, required on the prereplicativecomplex at replication origins for loading DNApolymerases to initiate DNA synthesis, alsorequired for S/M checkpoint control &radic0.146310.54923&radic S000003709RFA3YJL173CverifiedSubunit of heterotrimeric Replication Factor A (RF-A), which isa highly conserved single-stranded DNA bindingprotein involved in DNA replication, repair,and recombination &radic0.145860.54829&radic&radic S000004449NBP1YLR457CverifiedSpindle pole body (SPB) component, required for the insertionof the duplication plaque into the nuclearmembrane during SPB duplication; essential forbipolar spindle formation; component of theMps2p-Bbp1p complex 0.144670.54694&radic S000004470SPT5YML010WverifiedProtein that forms a complex with Spt4p and mediates bothactivation and inhibition of transcriptionelongation; Spt4p-Spt5p complex also plays arole in pre-mRNA processing 0.144170.54618&radic&radic&radic S000003617ARP4YJL081CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes &radic0.143320.5451&radic&radic S000003601DLS1YJL065CverifiedSubunit of ISW2/yCHRAC chromatin accessibility complex alongwith Itc1p, Isw2p, and Dpb4p; involved ininheritance of telomeric silencing 0.143280.54488&radic&radic S000006156RVB2YPL235WverifiedEssential protein involved in transcription regulation;component of chromatin remodeling complexes;required for assembly and function of the INO80complex; member of the RUVB-like protein family 0.143020.54416&radic&radic S000000014TPD3YAL016WverifiedRegulatory subunit A of the heterotrimeric protein phosphatase2A, which also contains regulatory subunitCdc55p and either catalytic subunit Pph21p orPph22p; required for cell morphogenesis and fortranscription by RNA polymerase III 0.142430.54357&radic S000002459DBF4YDR052CverifiedRegulatory subunit of Cdc7p-Dbf4p kinase complex, required forCdc7p kinase activity and initiation of DNAreplication; phosphorylates the Mcm2-7 familyof proteins; cell cycle regulated 0.141770.54186&radic&radic S000006050TAF14YPL129WverifiedSubunit (30 kDa) of TFIID, TFIIF, and SWI/SNF complexes,involved in RNA polymerase II transcriptioninitiation and in chromatin modification,contains a YEATS domain 0.141940.54186&radic&radic&radic S000003163GCN1YGL195WverifiedPositive regulator of the Gcn2p kinase activity, forms acomplex with Gcn20p; proposed to stimulateGcn2p activation by an uncharged tRNA 0.141220.54047&radic&radic S000005900NUD1YOR373WverifiedComponent of the spindle pole body outer plaque, required forexit from mitosis 0.138860.53584&radic S000003450CRM1YGR218WverifiedMajor karyopherin, involved in export of proteins, RNAs, andribosomal subunits from the nucleus 0.139170.53584&radic&radic&radic S000001924CDC14YFR028CverifiedProtein phosphatase required for mitotic exit; located in thenucleolus until liberated by the FEAR andMitotic Exit Network in anaphase, enabling itto act on key substrates to effect a decreasein CDK/B-cyclin activity and mitotic exit 0.138930.53584&radic&radic&radic&radic S000000435SWC5YBR231CuncharacterizedProtein of unknown function, component of the SWR1 complex,which exchanges histone variant H2AZ (Htz1p)for chromatin-bound histone H2A 0.138520.53507&radic&radic&radic&radic S000001857TUB2YFL037WverifiedBeta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p)to form tubulin dimer, which polymerizes toform microtubules 0.138410.53492&radic&radic&radic&radic S000000815PRP22YER013WverifiedDEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase,associates with lariat intermediates before thesecond catalytic step of splicing; mediatesATP-dependent mRNA release from the spliceosomeand unwinds RNA duplexes 0.137960.53363&radic&radic&radic S000001207DNA2YHR164CverifiedEssential tripartite DNA replication factor withsingle-stranded DNA-dependent ATPase,ATP-dependent nuclease, and helicaseactivities; required for Okazaki fragmentprocessing; involved in DNA repair pathways;potential Cdc28p substrate &radic0.136750.53179&radic&radic&radic&radic&radic S000003804POL32YJR043CverifiedThird subunit of DNA polymerase delta, involved in chromosomalDNA replication; required for error-prone DNAsynthesis in the presence of DNA damage andprocessivity; interacts with Hys2p, PCNA(Pol30p), and Pol1p &radic0.136320.5308&radic&radic&radic&radic S000000159KIP1YBL063WverifiedKinesin-related motor protein required for mitotic spindleassembly and chromosome segregation;functionally redundant with Cin8p 0.135960.53037&radic&radic&radic S000000493SNF5YBR289WverifiedSubunit of the SWI/SNF chromatin remodeling complex involved intranscriptional regulation; functionsinterdependently in transcriptional activationwith Snf2p and Snf6p 0.135710.52976&radic&radic S000002696NSE3YDR288WuncharacterizedEssential subunit of the Mms21-Smc5-Smc6 complex; protein ofunknown function; required for DNA repair andgrowth &radic0.135020.52837&radic&radic S000002284CDC48YDL126CverifiedATPase in ER, nuclear membrane and cytosol with homology tomammalian p97; in a complex with Npl4p andUfd1p participates in retrotranslocation ofubiquitinated proteins from the ER into thecytosol for degradation by the proteasome 0.134430.52666&radic&radic&radic S000004505VPS71YML041Cverifiednucleosome-binding component of the SWR1 complex, whichexchanges histone variant H2AZ (Htz1p) forchromatin-bound histone H2A; required forvacuolar protein sorting 0.133840.52555&radic&radic&radic S000005116APC1YNL172WverifiedLargest subunit of the Anaphase-Promoting Complex/Cyclosome(APC/C), which is a ubiquitin-protein ligaserequired for degradation of anaphaseinhibitors, including mitotic cyclins, duringthe metaphase/anaphase transition 0.133640.52516&radic&radic S000005162MGS1YNL218WverifiedProtein with DNA-dependent ATPase and ssDNA annealingactivities involved in maintenance of genome;interacts functionally with DNA polymerasedelta; homolog of human Werner helicaseinteracting protein (WHIP) 0.133210.52468&radic&radic&radic&radic&radic&radic S000002848DOT1YDR440WverifiedNucleosomal histone H3-Lys79 methylase, associates withtranscriptionally active genes, functions ingene silencing at telomeres, most likely bydirectly modulating chromatin structure and Sirprotein localization 0.131910.52135&radic S000004849TAF9YMR236WverifiedSubunit (17 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification, similar to histone H3 0.131910.52135&radic&radic&radic S000000950SPT15YER148WverifiedTATA-binding protein, general transcription factor thatinteracts with other factors to form thepreinitiation complex at promoters, essentialfor viability 0.131320.51968&radic S000001870EPL1YFL024CverifiedComponent of NuA4, which is an essential histone H4/H2Aacetyltransferase complex; homologous toDrosophila Enhancer of Polycomb 0.131180.51954&radic&radic S000003080TAF6YGL112CverifiedSubunit (60 kDa) of TFIID and SAGA complexes, involved intranscription initiation of RNA polymerase IIand in chromatin modification, similar tohistone H4 0.131040.51923&radic S000002263NSE4YDL105WverifiedNuclear protein that plays a role in the function of theSmc5p-Rhc18p complex &radic0.130790.51866&radic&radic S000002789YRA1YDR381WverifiedNuclear protein that binds to RNA and to Mex67p, required forexport of poly(A)+ mRNA from the nucleus;member of the REF (RNA and export factorbinding proteins) family; another familymember, Yra2p, can substitute for Yra1pfunction 0.129910.51655&radic&radic&radic&radic&radic S000000680TUP1YCR084CverifiedGeneral repressor of transcription, forms complex with Cyc8p,involved in the establishment of repressivechromatin structure through interactions withhistones H3 and H4, appears to enhanceexpression of some genes 0.129370.51532&radic&radic S000002856ADA2YDR448WverifiedTranscription coactivator, component of the ADA and SAGAtranscriptional adaptor/HAT (histoneacetyltransferase) complexes 0.128450.51377&radic&radic S000002222UBC9YDL064WverifiedSUMO-conjugating enzyme involved in the Smt3p conjugationpathway; nuclear protein required for S- andM-phase cyclin degradation and mitotic control;involved in proteolysis mediated by theanaphase-promoting complex cyclosome (APCC) 0.128490.51377&radic&radic&radic S000002483RAD55YDR076WverifiedProtein that stimulates strand exchange by stabilizing thebinding of Rad51p to single-stranded DNA;involved in the recombinational repair ofdouble-strand breaks in DNA during vegetativegrowth and meiosis; forms heterodimer withRad57p 0.127330.51151&radic&radic&radic&radic S000006115DDC1YPL194WverifiedDNA damage checkpoint protein, part of a PCNA-like complexrequired for DNA damage response, required forpachytene checkpoint to inhibit cell cycle inresponse to unrepaired recombinationintermediates; potential Cdc28p substrate 0.127150.51126&radic&radic&radic S000003628HPR5YJL092WverifiedDNA helicase and DNA-dependent ATPase involved in DNA repair,required for proper timing of commitment tomeiotic recombination and the transition fromMeiosis I to Meiosis II; potential Cdc28psubstrate 0.127040.5112&radic&radic S000000744EAF5YEL018WuncharacterizedEsa1p-associated factor, subunit of the NuA4 acetyltransferasecomplex 0.127010.51108&radic&radic&radic&radic&radic S000001238NVJ1YHR195WverifiedNuclear envelope protein that interacts with the vacuolarmembrane protein Vac8p to promote formation ofnucleus-vacuole junctions during piecemealmicroautophagy of the nucleus (PMN) 0.127010.51108&radic&radic&radic S000002545HPR1YDR138WverifiedSubunit of THO/TREX complexes that couple transcriptionelongation with mitotic recombination and withmRNA metabolism and export, subunit of an RNAPol II complex; regulates lifespan; involved intelomere maintenance; similar to Top1p 0.126650.51036&radic&radic&radic&radic&radic&radic S000005586YOR060CUncharacterizedProtein required for cell viability 0.126540.51036&radic&radic&radic S000001132YNG2YHR090CverifiedSubunit of the NuA4 histone acetyltransferase complex thatacetylates histone H4 and H2A; has similarityto the human tumor suppressor ING1 0.126470.50931&radic&radic&radic S000001923ECO1YFR027WverifiedAcetyltransferase required for the establishment of sisterchromatid cohesion during DNA replication, butnot for its maintenance during G2 and M phases;also required for postreplicative double-strandbreak repair; interacts with Chl1p &radic0.126030.50895&radic&radic&radic&radic&radic S000005564HIR2YOR038CverifiedNon-essential transcriptional corepressor involved in the cellcycle-regulated transcription of histone H2A,H2B, H3, and H4 genes; recruits Swi-Snfcomplexes to histone gene promoters; promotesheterochromatic gene silencing with Asf1p 0.125490.50806&radic&radic&radic&radic S000005083RLR1YNL139CverifiedSubunit of the THO complex, which is required for efficienttranscription elongation and involved intranscriptional elongation-associatedrecombination; required for LacZ RNA expressionfrom certain plasmids 0.125130.50786&radic&radic&radic S000003992NOC3YLR002CverifiedProtein that forms a nuclear complex with Noc2p that binds to66S ribosomal precursors to mediate theirintranuclear transport; also binds to chromatinto promote the association of DNA replicationfactors and replication initiation 0.124790.50712&radic&radic&radic&radic&radic S000000180CDC27YBL084CverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 0.124850.50712&radic&radic&radic S000000566MRC1YCL061CverifiedS-phase checkpoint protein found at replication forks, requiredfor DNA replication; also required for Rad53pactivation during DNA replication stress, whereit forms a replication-pausing complex withTof1p and is phosphorylated by Mec1p; proteininvolved in replication checkpoint &radic0.124710.50712&radic&radic&radic&radic S000000661HCM1YCR065WverifiedForkhead transcription factor that drives S-phase specificexpression of genes involved in chromosomesegregation, spindle dynamics, and budding;suppressor of calmodulin mutants with specificSPB assembly defects; telomere maintenance role 0.124810.50712&radic&radic&radic S000006305SNT309YPR101WverifiedComponent of NineTeen complex (NTC) containing Prp19p involvedin mRNA splicing, interacts physically andgenetically with Prp19p 0.124170.50584&radic&radic S000002323CDC9YDL164CverifiedDNA ligase found in the nucleus and mitochondria, an essentialenzyme that joins Okazaki fragments during DNAreplication; also acts in nucleotide excisionrepair, base excision repair, and recombination &radic0.12410.50584&radic&radic&radic&radic S000005831ISW2YOR304WverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPasecomponent that, with Itc1p, forms a complexrequired for repression of a-specific genes,INO1, and early meiotic genes during mitoticgrowth 0.123050.50209&radic&radic&radic&radic S000005377ESC8YOL017WverifiedProtein involved in telomeric and mating-type locus silencing,interacts with Sir2p and also interacts withthe Gal11p, which is a component of the RNA polII mediator complex 0.122840.5017&radic&radic&radic&radic S000002800SPT3YDR392WverifiedSubunit of the SAGA and SAGA-like transcriptional regulatorycomplexes, interacts with Spt15p to activatetranscription of some RNA polymeraseII-dependent genes, also functions to inhibittranscription at some promoters 0.122560.50104&radic&radic&radic S000002537FIN1YDR130CverifiedSpindle pole body-related intermediate filament protein, formscell cycle-specific filaments between spindlepole bodies in mother and daughter cells, ableto self-assemble, expression induced duringS/G2, localization cell-cycle dependent 0.121820.49885&radic&radic&radic&radic S000003213RTF1YGL244WverifiedSubunit of the RNA polymerase II-associated Paf1 complex;directly or indirectly regulates DNA-bindingproperties of Spt15p and relative activities ofdifferent TATA elements; involved in telomeremaintenance 0.121680.49885&radic&radic&radic&radic&radic S000000302MMS4YBR098WverifiedSubunit of the structure-specific Mms4p-Mus81p endonucleasethat cleaves branched DNA; involved inrecombination and DNA repair 0.121660.49885&radic&radic&radic S000000318RAD16YBR114WverifiedProtein that recognizes and binds damaged DNA in anATP-dependent manner (with Rad7p) duringnucleotide excision repair; subunit ofNucleotide Excision Repair Factor 4 (NEF4);member of the SWI/SNF family 0.121070.49761&radic S000002292PPH21YDL134CverifiedCatalytic subunit of protein phosphatase 2A, functionallyredundant with Pph22p; methylated at Cterminus; forms alternate complexes withseveral regulatory subunits; involved in signaltransduction and regulation of mitosis 0.120620.49676&radic&radic S000002777XRS2YDR369CverifiedProtein required for DNA repair; component of the Mre11complex, which is involved in double strandbreaks, meiotic recombination, telomeremaintenance, and checkpoint signaling 0.119780.49475&radic&radic&radic&radic&radic&radic&radic S000004075ARP6YLR085CverifiedActin-related protein that binds nucleosomes; a component ofthe SWR1 complex, which exchanges histonevariant H2AZ (Htz1p) for chromatin-boundhistone H2A 0.119980.49475&radic&radic&radic&radic S000002379CDC13YDL220CverifiedSingle stranded DNA-binding protein found at TG1-3 telomereG-tails; regulates telomere replication throughrecruitment of specific sub-complexes, but theessential function is telomere capping &radic0.11960.49475&radic&radic&radic S000004570CAC2YML102WverifiedComponent of the chromatin assembly complex (with Rlf2p andMsi1p) that assembles newly synthesizedhistones onto recently replicated DNA, requiredfor building functional kinetochores, conservedfrom yeast to humans &radic0.119370.49386&radic S000002589SAS4YDR181CverifiedSubunit of the SAS complex (Sas2p, Sas4p, Sas5p), whichacetylates free histones and nucleosomes andregulates transcriptional silencing; requiredfor the HAT activity of Sas2p &radic0.119110.49345&radic&radic&radic&radic S000002494RRP1YDR087CverifiedEssential evolutionarily conserved nucleolar protein necessaryfor biogenesis of 60S ribosomal subunits andprocessing of pre-rRNAs to mature rRNAs,associated with several distinct 66Spre-ribosomal particles 0.118680.49144&radic&radic&radic&radic&radic S000005505CTR9YOL145CverifiedComponent of the Paf1p complex, which is a large complex thatbinds to and modulates the activity of RNApolymerase II and is required for expression ofa subset of genes, including cyclin genes;contains TPR repeats 0.11840.49144&radic&radic S000004651CSM3YMR048WverifiedProtein required for accurate chromosome segregation duringmeiosis 0.117340.48793&radic&radic S000003118INO80YGL150CverifiedATPase that forms a large complex, containing actin and severalactin-related proteins, that has chromatinremodeling activity and 3' to 5' DNA helicaseactivity in vitro; shows similarity to theSnf2p family of ATPases 0.117130.48793&radic S000003101ITC1YGL133WverifiedComponent of the ATP-dependent Isw2p-Itc1p chromatin remodelingcomplex, required for repression of a-specificgenes, repression of early meiotic genes duringmitotic growth, and repression of INO1 0.116490.48577&radic S000004650NUP116YMR047CverifiedSubunit of the nuclear pore complex (NPC) that is localized toboth sides of the pore; contains a repetitiveGLFG motif that interacts with mRNA exportfactor Mex67p and with karyopherin Kap95p;homologous to Nup100p 0.115880.48493&radic&radic&radic S000005401NOP12YOL041CverifiedNucleolar protein, required for pre-25S rRNA processing;contains an RNA recognition motif (RRM) and hassimilarity to Nop13p, Nsr1p, and putativeorthologs in Drosophila and S. pombe 0.115720.48313&radic&radic S000000449ISW1YBR245CverifiedMember of the imitation-switch (ISWI) class of ATP-dependentchromatin remodeling complexes; ATPase thatforms a complex with Ioc2p and Ioc4p toregulate transcription elongation, and acomplex with Ioc3p to repress transcriptioninitiation 0.115690.48313&radic&radic&radic&radic&radic&radic S000004901HSH155YMR288WverifiedU2-snRNP associated splicing factor that forms extensiveassociations with the branch site-3' splicesite-3' exon region upon prespliceosomeformation; similarity to the mammalian U2snRNP-associated splicing factor SAP155 0.115640.48313&radic&radic&radic&radic&radic S000006365SGV1YPR161CverifiedCyclin (Bur2p)-dependent protein kinase that functions intranscriptional regulation; phosphorylates thecarboxy-terminal domain of Rpo21p, which is thelargest subunit of RNA polymerase II; regulatedby Cak1p 0.115270.48301&radic&radic&radic&radic S000000966CHD1YER164WverifiedNucleosome remodeling factor that functions in regulation oftranscription elongation; contains a chromodomain, a helicase domain and a DNA-bindingdomain; component of both the SAGA and SILKcomplexes 0.115160.48284&radic S000001505CDC16YKL022CverifiedSubunit of the anaphase-promoting complex/cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition; required forsporulation 0.114820.48228&radic&radic&radic&radic S000001335SPO22YIL073CverifiedMeiosis-specific protein essential for chromosome synapsis,similar to phospholipase A2, involved incompletion of nuclear divisions during meiosis;induced early in meiosis 0.114110.47978&radic&radic&radic&radic S000003506TAF1YGR274CverifiedTFIID subunit (145 kDa), involved in RNA polymerase IItranscription initiation, has histoneacetyltransferase activity, involved inpromoter binding and G1/S progression 0.114170.47978&radic&radic&radic&radic S000006149CET1YPL228WverifiedBeta (RNA 5'-triphosphatase) subunit of the mRNA cappingenzyme, a heterodimer (the other subunit isCEG1, a guanylyltransferase) involved in addingthe 5' cap to mRNA; the mammalian enzyme is asingle bifunctional polypeptide 0.114160.47978&radic&radic&radic&radic S000000104HIR1YBL008WverifiedNon-essential transcriptional corepressor involved in the cellcycle-regulated transcription of histone H2A,H2B, H3 and H4 genes; contributes to nucleosomeformation, heterochromatic gene silencing, andformation of functional kinetochores &radic0.113650.47927&radic&radic&radic&radic S000005226POP3YNL282WverifiedSubunit of both RNase MRP, which cleaves pre-rRNA, and nuclearRNase P, which cleaves tRNA precursors togenerate mature 5' ends 0.113220.47799&radic&radic S000001591SLD2YKL108WverifiedProtein required for DNA replication, phosphorylated in S phaseby S-phase cyclin-dependent kinases (Cdks),phosphorylation is essential for DNAreplication and for complex formation withDpb11p; potential Cdc28p substrate &radic0.112190.47482&radic&radic&radic S000004603CDC5YMR001CverifiedPolo-like kinase with similarity to Xenopus Plx1 and S. pombePlo1p; found at bud neck, nucleus and SPBs; hasmultiple functions in mitosis and cytokinesisthrough phosphorylation of substrates; may be aCdc28p substrate 0.111160.47287&radic&radic&radic&radic S000002290CDC53YDL132WverifiedCullin, structural protein of SCF complexes (which also containSkp1p, Cdc34p, and an F-box protein) involvedin ubiquitination; SCF promotes the G1-Stransition by targeting G1 cyclins and theCln-CDK inhibitor Sic1p for degradation 0.110040.47035&radic&radic&radic S000001933RSC8YFR037CverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; essential for viability andmitotic growth; homolog of SWI/SNF subunitSwi3p, but unlike Swi3p, does not activatetranscription of reporters 0.109940.47023&radic&radic&radic&radic&radic S000004605YMR003WUncharacterizedProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria; YMR003W is not an essential gene 0.109870.46995&radic&radic&radic S000000127SHE1YBL031WverifiedCytoskeletal protein of unknown function; overexpression causesgrowth arrest 0.109670.46936&radic&radic&radic S000001789RPF2YKR081CverifiedEssential protein involved in the processing of pre-rRNA andthe assembly of the 60S ribosomal subunit;interacts with ribosomal protein L11; localizespredominantly to the nucleolus; constituent of66S pre-ribosomal particles 0.109490.46888&radic&radic S000004377SWC7YLR385CverifiedProtein of unknown function, component of the Swr1p complexthat incorporates Htz1p into chromatin 0.109350.46888&radic&radic&radic S000000688MSH3YCR092CverifiedMismatch repair protein, forms dimers with Msh2p that mediaterepair of insertion or deletion mutations andremoval of nonhomologous DNA ends, contains aPCNA (Pol30p) binding motif required for genomestability 0.109250.46811&radic&radic&radic S000003081SLD3YGL113WverifiedProtein involved in the initiation of DNA replication, requiredfor proper assembly of replication proteins atthe origins of replication; interacts withCdc45p &radic0.108940.46798&radic&radic S000003550MAD3YJL013CverifiedComponent of the spindle-assembly checkpoint complex, whichdelays the onset of anaphase in cells withdefects in mitotic spindle assembly; interactsphysically with the spindle checkpoint proteinsBub3p and Mad2p 0.108780.46771&radic S000000399MSI1YBR195CverifiedSubunit of chromatin assembly factor I (CAF-I), regulates theRAS/cAMP pathway via sequestration of Npr1pkinase; localizes to the nucleus and cytoplasm;homologous to human retinoblastoma bindingproteins RbAp48 and RbAp46 0.10880.46771&radic&radic&radic&radic S000004022RAD5YLR032WverifiedSingle-stranded DNA-dependent ATPase, involved inpostreplication repair; contains RING fingerdomain &radic0.107690.46516&radic&radic&radic&radic S000002635SIR4YDR227WverifiedSilent information regulator that, together with SIR2 and SIR3,is involved in assembly of silent chromatindomains at telomeres and the silent mating-typeloci; potentially phosphorylated by Cdc28p;some alleles of SIR4 prolong lifespan &radic0.107540.46516&radic&radic&radic&radic S000003959PRP19YLL036CverifiedSplicing factor associated with the spliceosome; contains aU-box, a motif found in a class of ubiquitinligases 0.107630.46516&radic&radic&radic&radic&radic&radic S000001195SPO12YHR152WverifiedNucleolar protein of unknown function, positive regulator ofexit from mitosis; involved in regulating therelease of Cdc14p from the nucleolus in earlyanaphase; proposed to play similar role inmeiosis 0.10720.46431&radic&radic&radic&radic S000002411RAD57YDR004WverifiedProtein that stimulates strand exchange by stabilizing thebinding of Rad51p to single-stranded DNA;involved in the recombinational repair ofdouble-strand breaks in DNA during vegetativegrowth and meiosis; forms heterodimer withRad55p 0.107110.46392&radic&radic S000005583SGT1YOR057WverifiedProbable cochaperone, regulates activity of Cyr1p (adenylylcyclase); involved in assembly of thekinetochore complex, associates with the SCF(Skp1p/Cdc53p/F box protein) ubiquitin ligasecomplex 0.106670.46282&radic&radic&radic S000001069RPN1YHR027CverifiedNon-ATPase base subunit of the 19S regulatory particle of the26S proteasome; may participate in therecognition of several ligands of theproteasome; contains a leucine-rich repeat(LRR) domain, a site for protein?proteininteractions 0.106750.46282&radic&radic&radic&radic&radic S000005366TOP1YOL006CverifiedTopoisomerase I, nuclear enzyme that relieves torsional strainin DNA by cleaving and re-sealing thephosphodiester backbone; relaxes bothpositively and negatively supercoiled DNA;functions in replication, transcription, andrecombination 0.106740.46282&radic&radic&radic&radic S000002461CDC34YDR054CverifiedUbiquitin-conjugating enzyme or E2; together with Skp1p, Rbx1p,Cdc53p, and an F-box protein, forms aubiquitin-protein ligase called the SCF complexwhich regulates cell cycle progression bytargeting key substrates for degradation 0.105610.45942&radic&radic&radic&radic&radic S000005552BUB3YOR026WverifiedKinetochore checkpoint WD40 repeat protein that localizes tokinetochores during prophase and metaphase,delays anaphase in the presence of unattachedkinetochores; forms complexes with Mad1p-Bub1pand with Cdc20p, binds Mad2p and Mad3p &radic0.105260.45886&radic&radic&radic&radic S000005527RRP6YOR001WverifiedExonuclease component of the nuclear exosome; contributes tothe quality-control system that retains anddegrades aberrant mRNAs in the nucleus 0.1050.45802&radic&radic&radic S000004527MFT1YML062CverifiedSubunit of the THO complex, which is a nuclear complexcomprised of Hpr1p, Mft1p, Rlr1p, and Thp2p,that is involved in transcription elongationand mitotic recombination; involved in telomeremaintenance 0.104870.45746&radic&radic&radic S000000913SWI4YER111CverifiedDNA binding component of the SBF complex (Swi4p-Swi6p), atranscriptional activator that in concert withMBF (Mbp1-Swi6p) regulates late G1-specifictranscription of targets including cyclins andgenes required for DNA synthesis and repair 0.10460.45708&radic&radic S000003821CBF1YJR060WverifiedHelix-loop-helix protein that binds the motif CACRTG, which ispresent at several sites including MET genepromoters and centromere DNA element I (CDEI);required for nucleosome positioning at thismotif; targets Isw1p to DNA &radic0.104520.45708&radic&radic S000001163LSM12YHR121WverifiedProtein of unknown function that interacts with Pbp1p and Pbp4pand associates with ribosomes; contains anRNA-binding LSM domain and an AD domain; mayplay a role in RNA processing 0.104480.4564&radic&radic S000002907LCD1YDR499WverifiedEssential protein required for the DNA integrity checkpointpathways; interacts physically with Mec1p;putative homolog of S. pombe Rad26 and humanATRIP 0.103770.45438&radic&radic&radic S000002299RPO21YDL140CverifiedRNA polymerase II largest subunit B220, part of central core;phosphorylation of C-terminal heptapeptiderepeat domain regulates association withtranscription and splicing factors; similar tobacterial beta-prime 0.102960.45245&radic&radic S000003055MMS2YGL087CverifiedProtein involved in error-free postreplication DNA repair;forms a heteromeric complex with Ubc13p thathas a ubiquitin-conjugating activity;cooperates with chromatin-associated RINGfinger proteins, Rad18p and Rad5p 0.102950.45245&radic&radic&radic&radic&radic&radic&radic S000005145PSY2YNL201CverifiedPutative subunit of an evolutionarily conserved proteinphosphatase complex containing the catalyticsubunit Pph3p and the regulatory subunit Psy4p;required for cisplatin and oxaliplatinresistance; localizes to nucleus 0.103160.45245&radic&radic S000005180SIN4YNL236WverifiedSubunit of the Mediator complex; interacts with the RNApolymerase II holoenzyme to postively ornegatively regulate transcription; dispensiblefor basal transcription 0.102540.45154&radic&radic&radic S000000168RPS8AYBL072CverifiedProtein component of the small (40S) ribosomal subunit;identical to Rps8Bp and has similarity to ratS8 ribosomal protein 0.10260.45154&radic&radic&radic S000002812RPB7YDR404CverifiedRNA polymerase II subunit B16; forms two subunit dissociablecomplex with Rpb4p 0.10230.45068&radic&radic&radic S000003545CCT8YJL008CverifiedSubunit of the cytosolic chaperonin Cct ring complex, relatedto Tcp1p, required for the assembly of actinand tubulins in vivo 0.102040.44981&radic&radic S000004837MRE11YMR224CverifiedSubunit of a complex with Rad50p and Xrs2p (RMX complex) thatfunctions in repair of DNA double-strand breaksand in telomere stability, exhibits nucleaseactivity that appears to be required for RMXfunction; widely conserved 0.101730.44946&radic&radic&radic&radic&radic S000001208PRP8YHR165CverifiedComponent of the U4/U6-U5 snRNP complex, involved in the secondcatalytic step of splicing 0.101650.44946&radic&radic&radic S000000392NTC20YBR188CverifiedMember of a complex, including Prp19p, that binds to thespliceosome; required for pre-mRNA splicing 0.101360.44839&radic&radic&radic&radic&radic&radic S000001608RRN3YKL125WverifiedProtein required for transcription of rDNA by RNA polymerase I;transcription factor independent of DNAtemplate; involved in recruitment of RNApolymerase I to rDNA 0.101250.44823&radic&radic&radic&radic S000004565ARG81YML099CverifiedZinc-finger transcription factor of the Zn(2)-Cys(6) binuclearcluster domain type, involved in the regulationof arginine-responsive genes; acts with Arg80pand Arg82p 0.100950.44709&radic&radic&radic&radic S000004165CBF5YLR175WverifiedPseudouridine synthase catalytic subunit of box H/ACA smallnucleolar ribonucleoprotein particles(snoRNPs), acts on both large and small rRNAsand on snRNA U2 0.100640.44639&radic&radic&radic&radic&radic&radic S000005587CKA2YOR061WverifiedAlpha' catalytic subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKB1 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.100510.44607&radic&radic&radic S000002315YDL156WUncharacterizedHypothetical protein 0.100430.44515&radic&radic S000004224TOP3YLR234WverifiedDNA Topoisomerase III, conserved protein that functions in acomplex with Sgs1p and Rmi1p to relaxsingle-stranded negatively-supercoiled DNApreferentially, involved in telomere stabilityand regulation of mitotic recombination 0.100280.44515&radic&radic&radic&radic&radic S000000605PGK1YCR012Wverified3-phosphoglycerate kinase, catalyzes transfer of high-energyphosphoryl groups from the acyl phosphate of1,3-bisphosphoglycerate to ADP to produce ATP;key enzyme in glycolysis and gluconeogenesis 0.100220.44499&radic&radic&radic&radic S000006048HHO1YPL127CverifiedHistone H1, a linker histone required for nucleosome packagingat restricted sites; suppresses DNA repairinvolving homologous recombination; notrequired for telomeric silencing, basaltranscriptional repression, or efficientsporulation &radic0.100240.44499&radic&radic&radic&radic&radic&radic S000004064BUD20YLR074CverifiedProtein involved in bud-site selection; diploid mutants displaya random budding pattern instead of thewild-type bipolar pattern 0.100150.44465&radic&radic&radic&radic&radic S000000961BUR6YER159CverifiedProtein that forms a heterodimeric histone-fold NC2 generaltranscription regulator complex with Ydr1p thatbinds to TBP and represses RNA pol IItranscription during assembly of thepreinitiation complex, homologous to humanNC2alpha 0.100110.44465&radic&radic&radic S000002499UBC13YDR092WverifiedUbiquitin-conjugating enzyme involved in the error-free DNApostreplication repair pathway; interacts withMms2p to assemble ubiquitin chains at the UbLys-63 residue; DNA damage triggersredistribution from the cytoplasm to thenucleus 0.100030.44367&radic&radic S000005130UBP10YNL186WverifiedUbiquitin-specific protease that deubiquitinatesubiquitin-protein moieties; may regulatesilencing by acting on Sir4p; involved inposttranscriptionally regulating Gap1p andpossibly other transporters; primarily locatedin the nucleus 0.10.44367&radic&radic S000001809SIR1YKR101WverifiedProtein involved in repression of transcription at the silentmating-type loci HML and HMR; recruitment tosilent chromatin requires interactions withOrc1p and with Sir4p, through a common Sir1pdomain; binds to centromeric chromatin 0.099890.44367&radic S000003026RAD6YGL058WverifiedUbiquitin-conjugating enzyme (E2), involved in postreplicationrepair (with Rad18p), sporulation, telomeresilencing, and ubiquitin-mediated N-end ruleprotein degradation (with Ubr1p) 0.099590.44316&radic&radic&radic&radic&radic&radic S000005531DNL4YOR005CverifiedDNA ligase required for nonhomologous end-joining (NHEJ), formsstable heterodimer with required cofactorLif1p, catalyzes DNA ligation as part of acomplex with Lif1p and Nej1p; involved inmeiosis, not essential for vegetative growth 0.099640.44316&radic&radic S000000479RIF1YBR275CverifiedProtein that binds to the Rap1p C-terminus and actssynergistically with Rif2p to help controltelomere length and establish telomericsilencing; deletion results in telomereelongation &radic0.099410.44243&radic&radic S000002859YHP1YDR451CverifiedOne of two homeobox transcriptional repressors (see alsoYox1p), that bind to Mcm1p and to early cellcycle box (ECB) elements of cell cycleregulated genes, thereby restrictingECB-mediated transcription to the M/G1 interval 0.099240.44201&radic&radic S000003945HIF1YLL022CverifiedNon-essential component of the HAT-B histone acetyltransferasecomplex (Hat1p-Hat2p-Hif1p), localized to thenucleus; has a role in telomeric silencing 0.09920.44201&radic S000005475PAP2YOL115WverifiedCatalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), anuclear poly (A) polymerase complex involved inRNA quality control; catalyzes polyadenylationof unmodified tRNAs, and snoRNA and rRNAprecursors; disputed role as a DNA polymerase 0.099120.44148&radic&radic S000004365VID22YLR373CverifiedGlycosylated integral membrane protein localized to the plasmamembrane; plays a role infructose-1,6-bisphosphatase (FBPase)degradation; involved in FBPase transport fromthe cytosol to Vid (vacuole import anddegradation) vesicles 0.099180.44148&radic&radic&radic&radic&radic&radic S000005077FYV6YNL133CverifiedProtein of unknown function, required for survival uponexposure to K1 killer toxin; proposed toregulate double-strand break repair vianon-homologous end-joining 0.099120.44148&radic&radic S000005176CSL4YNL232WverifiedSubunit of the exosome, which is an essential complex presentin both nucleus and cytoplasm that mediates RNAprocessing and degradation 0.098580.4402&radic&radic&radic&radic S000004447YLR455WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR455W is not an essential gene 0.098170.43938&radic&radic S000002490RRP8YDR083WverifiedNucleolar protein involved in rRNA processing, pre-rRNAcleavage at site A2; also involved in telomeremaintenance; mutation is synthetically lethalwith a gar1 mutation 0.098010.43834&radic&radic S000006339CTF4YPR135WverifiedChromatin-associated protein, required for sister chromatidcohesion; interacts with DNA polymerase alpha(Pol1p) and may link DNA synthesis to sisterchromatid cohesion 0.098020.43834&radic&radic&radic&radic&radic S000002200SIR2YDL042CverifiedConserved NAD+ dependent histone deacetylase of the Sirtuinfamily involved in regulation of lifespan;plays roles in silencing at HML, HMR,telomeres, and the rDNA locus; negativelyregulates initiation of DNA replication &radic0.097620.43768&radic&radic S000005649LEO1YOR123CverifiedComponent of the Paf1 complex, which associates with RNApolymerase II and is involved in histonemethylation 0.09770.43768&radic&radic&radic&radic&radic&radic S000002987CKB1YGL019WverifiedBeta regulatory subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKA2 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.097420.43758&radic&radic&radic S000005411GAL11YOL051WverifiedComponent of the Mediator complex; interacts with RNApolymerase II and the general transcriptionfactors to form the RNA polymerase IIholoenzyme; affects transcription by acting astarget of activators and repressors 0.097380.43758&radic&radic S000002918SMT3YDR510WverifiedUbiquitin-like protein of the SUMO family, conjugated to lysineresidues of target proteins; regulateschromatid cohesion, chromosome segregation,APC-mediated proteolysis, DNA replication andseptin ring dynamics 0.097260.43631&radic&radic S000002770TFC6YDR362CverifiedOne of six subunits of RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part ofTFIIIC TauB domain that binds BoxB promotersites of tRNA and other genes; cooperates withTfc3p in DNA binding; human homolog isTFIIIC-110 0.097120.43631&radic&radic&radic S000006067NOP53YPL146CverifiedNucleolar protein; involved in biogenesis of the 60S subunit ofthe ribosome; interacts with rRNA processingfactors Cbf5p and Nop2p; null mutant is viablebut growth is severely impaired 0.097150.43631&radic&radic S000001855ACT1YFL039CverifiedActin, structural protein involved in cell polarization,endocytosis, and other cytoskeletal functions 0.096870.43587&radic&radic S000002228BDF2YDL070WverifiedProtein involved in transcription initiation at TATA-containingpromoters; associates with the basaltranscription factor TFIID; contains twobromodomains; corresponds to the C-terminalregion of mammalian TAF1; redundant with Bdf1p 0.096750.43538&radic&radic&radic S000000277RDH54YBR073WverifiedDNA-dependent ATPase, stimulates strand exchange by modifyingthe topology of double-stranded DNA; involvedin the recombinational repair of double-strandbreaks in DNA during mitosis and meiosis;proposed to be involved in crossoverinterference 0.096750.43538&radic&radic S000000662RAD18YCR066WverifiedProtein involved in postreplication repair; bindssingle-stranded DNA and has single-stranded DNAdependent ATPase activity; forms heterodimerwith Rad6p; contains RING-finger motif &radic0.096770.43538&radic S000002711RSC3YDR303CverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; essential gene required forregulation of ribosomal protein genes and thecell wall/stress response; highly similar toRsc30p 0.096570.43472&radic&radic S000004489YOX1YML027WverifiedHomeodomain-containing transcriptional repressor, binds toMcm1p and to early cell cycle boxes (ECBs) inthe promoters of cell cycle-regulated genesexpressed in M/G1 phase; expression is cellcycle-regulated; potential Cdc28p substrate 0.096380.43398&radic&radic S000004791SPT21YMR179WverifiedProtein required for normal transcription at several lociincluding HTA2-HTB2 and HHF2-HHT2, but notrequired at the other histone loci;functionally related to Spt10p; involved intelomere maintenance 0.096380.43398&radic&radic&radic&radic S000003583RTT101YJL047CverifiedCullin subunit of a Roc1p-dependent E3 ubiquitin ligasecomplex; deletion phenotype suggests a role inanaphase progression; interacts with Mms22p andimplicated in Mms22-dependent DNA repair;modified by the ubiquitin-like protein, Rub1p 0.096230.43384&radic&radic&radic S000000678AHC2YCR082WuncharacterizedProtein of unknown function, putative transcriptionalregulator; proposed to be a Ada Histoneacetyltransferase complex component; GFP taggedprotein is localized to the cytoplasm andnucleus 0.095890.43248&radic&radic&radic&radic&radic S000004814RAD14YMR201CverifiedProtein that recognizes and binds damaged DNA during nucleotideexcision repair; subunit of Nucleotide ExcisionRepair Factor 1 (NEF1); contains zinc fingermotif; homolog of human XPA protein 0.095710.432&radic&radic&radic&radic S000003567MAD2YJL030WverifiedComponent of the spindle-assembly checkpoint complex, whichdelays the onset of anaphase in cells withdefects in mitotic spindle assembly; forms acomplex with Mad1p &radic0.095490.43195&radic S000003466YHB1YGR234WverifiedNitric oxide oxidoreductase, flavohemoglobin involved in nitricoxide detoxification; plays a role in theoxidative and nitrosative stress responses 0.095340.43173&radic S000001511TFA1YKL028WverifiedTFIIE large subunit, involved in recruitment of RNA polymeraseII to the promoter, activation of TFIIH, andpromoter opening 0.094870.42994&radic&radic&radic&radic S000000362AMN1YBR158WverifiedProtein required for daughter cell separation, multiple mitoticcheckpoints, and chromosome stability; contains12 degenerate leucine-rich repeat motifs;expression is induced by the Mitotic ExitNetwork (MEN) 0.095020.42994&radic&radic S000006323CLB2YPR119WverifiedB-type cyclin involved in cell cycle progression; activatesCdc28p to promote the transition from G2 to Mphase; accumulates during G2 and M, thentargeted via a destruction box motif forubiquitin-mediated degradation by theproteasome 0.094990.42994&radic&radic&radic&radic S000005450MSH2YOL090WverifiedProtein that forms heterodimers with Msh3p and Msh6p that bindto DNA mismatches to initiate the mismatchrepair process; contains a Walker ATP-bindingmotif required for repair activity; Msh2p-Msh6pbinds to and hydrolyzes ATP 0.094820.42994&radic&radic&radic&radic S000004023RSC58YLR033WverifiedRemodels the structure of chromatin complex 58KDa subunit;Chromatin Remodeling Complex subunit 0.094820.42994&radic&radic S000005012FKH2YNL068CverifiedForkhead family transcription factor with a major role in theexpression of G2/M phase genes; positivelyregulates transcriptional elongation; negativerole in chromatin silencing at HML and HMR;substrate of the Cdc28p/Clb5p kinase 0.094680.42928&radic S000003502YTA7YGR270WverifiedProtein of unknown function, member of CDC48/PAS1/SEC18 familyof ATPases, potentially phosphorylated byCdc28p 0.094430.42875&radic&radic&radic S000006269ROX1YPR065WverifiedHeme-dependent repressor of hypoxic genes; contains an HMGdomain that is responsible for DNA bendingactivity 0.094410.42828&radic S000001249SKN7YHR206WverifiedNuclear response regulator and transcription factor, part of abranched two-component signaling system;required for optimal induction of heat-shockgenes in response to oxidative stress; involvedin osmoregulation 0.094320.42828&radic&radic&radic&radic&radic S000001909IOC3YFR013WverifiedMember of a complex (Isw1a) with Isw1p that hasnucleosome-stimulated ATPase activity andrepresses transcription initiation by specificpositioning of a promoter proximaldinucleosome; has homology to Esc8p, which isinvolved in silencing 0.094250.42805&radic&radic&radic S000005732NOC2YOR206WverifiedProtein that forms a nucleolar complex with Mak21p that bindsto 90S and 66S pre-ribosomes, as well as anuclear complex with Noc3p that binds to 66Spre-ribosomes; both complexes mediateintranuclear transport of ribosomal precursors 0.09410.42761&radic&radic S000005381DIS3YOL021CverifiedNucleolar exosome component, involved in rRNA processing andRNA degradation, binds Gsp1p/Ran and enhancesthe GEF activity of Srm1p, implicated inmitotic control, homologous to the E. coliRNase R of the RNase II family 0.094070.42761&radic&radic&radic&radic&radic S000004712YKU80YMR106CverifiedSubunit of the telomeric Ku complex (Yku70p-Yku80p), involvedin telomere length maintenance, structure andtelomere position effect; relocates to sites ofdouble-strand cleavage to promote nonhomologousend joining during DSB repair &radic0.094060.42759&radic&radic&radic&radic S000003303YGR071CUncharacterizedPutative protein of unknown function; deletion mutant has increased glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the nucleus 0.093950.42729&radic&radic&radic&radic S000004507RRN11YML043CverifiedProtein required for rDNA transcription by RNA polymerase I,component of the core factor (CF) of rDNAtranscription factor, which also contains Rrn6pand Rrn7p 0.093880.42676 S000003901HIR3YJR140CverifiedTranscriptional corepressor involved in the cellcycle-regulated transcription of histone genesHTA1, HTB1, HHT1, and HHT2; involved inposition-dependent gene silencing andnucleosome reassembly 0.09360.42549&radic&radic S000003842EAF6YJR082CuncharacterizedEsa1p-associated factor, subunit of the NuA4 acetyltransferasecomplex 0.093540.42549&radic&radic&radic S000001770TFA2YKR062WverifiedTFIIE small subunit, involved in RNA polymerase IItranscription initiation 0.093280.42471&radic&radic&radic&radic S000004802SGS1YMR190CverifiedNucleolar DNA helicase of the RecQ family involved inmaintenance of genome integrity, regulateschromosome synapsis and meiotic crossing over;has similarity to human BLM and WRN helicasesimplicated in Bloom and Werner syndromes 0.092910.42356&radic&radic&radic&radic S000003712SWI3YJL176CverifiedSubunit of the SWI/SNF chromatin remodeling complex, whichregulates transcription by remodelingchromosomes; required for transcription of manygenes, including ADH1, ADH2, GAL1, HO, INO1 andSUC2 0.093010.42356&radic&radic S000005739SAS5YOR213CverifiedSubunit of the SAS complex (Sas2p, Sas4p, Sas5p), whichacetylates free histones and nucleosomes andregulates transcriptional silencing; stimulatesSas2p HAT activity &radic0.092810.42356&radic&radic&radic&radic&radic S000003361SYF2YGR129WverifiedComponent of the spliceosome complex involved in pre-mRNAsplicing; involved in regulation of cell cycleprogression 0.092970.42356&radic&radic&radic&radic S000000974BRR2YER172CverifiedRNA-dependent ATPase RNA helicase involved in the facilitationand disruption of snRNA interactions, requiredfor disruption of U4/U6 base-pairing in nativesnRNPs to activate the spliceosome forcatalysis 0.092910.42356&radic&radic&radic S000003003MIG1YGL035CverifiedTranscription factor involved in glucose repression; C2H2 zincfinger protein similar to mammalian Egr andWilms tumor proteins 0.092930.42356&radic&radic&radic S000000763RAD23YEL037CverifiedProtein with ubiquitin-like N terminus, recognizes and bindsdamaged DNA (with Rad4p) during nucleotideexcision repair; regulates Rad4p levels,subunit of Nuclear Excision Repair Factor 2(NEF2); homolog of human HR23A and HR23Bproteins 0.092740.4233&radic&radic&radic S000006314RPC40YPR110CverifiedRNA polymerase subunit, common to RNA polymerase I and III 0.092740.4233&radic&radic&radic&radic&radic S000005468INO4YOL108CverifiedTranscription factor required for derepression ofinositol-choline-regulated genes involved inphospholipid synthesis; forms a complex, withIno2p, that binds theinositol-choline-responsive element through abasic helix-loop-helix domain 0.092740.4233&radic&radic S000000339CKS1YBR135WverifiedSubunit of the Cdc28 protein kinase, required for mitoticproteolysis, may also be involved in theproteolysis of the G1 cyclins 0.09250.42211&radic&radic&radic S000004322CHS5YLR330WverifiedProtein involved in export from the Golgi to plasma membrane;involved in chitin biosynthesis through itsrole in Chs3p localization; interacts withArf1p, Bch1p, Fmp50p, Bud7p, and Chs6p 0.092530.42211 S000003016RPT6YGL048CverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; bound byubiquitin-protein ligases Ubr1p and Ufd4p;localized mainly to the nucleus throughout thecell cycle 0.092710.42211&radic&radic&radic&radic&radic S000000483PAF1YBR279WverifiedRNA polymerase II-associated protein, defines a large complexthat is biochemically and functionally distinctfrom the Srb-Mediator form of Pol II holoenzymeand is required for full expression of a subsetof cell cycle-regulated genes 0.092420.42211&radic&radic&radic S000004560RAD10YML095CverifiedSingle-stranded DNA endonuclease (with Rad1p), cleavessingle-stranded DNA during nucleotide excisionrepair and double-strand break repair; subunitof Nucleotide Excision Repair Factor 1 (NEF1);homolog of human ERCC1 protein 0.091810.42007&radic&radic&radic S000004681PDS5YMR076CverifiedProtein required for establishment and maintenance of sisterchromatid condensation and cohesion,colocalizes with cohesin on chromosomes in aninterdependent manner, may function as aprotein-protein interaction scaffold 0.091660.41882&radic&radic S000004871YMR258CUncharacterizedProtein of unknown function with similarity to F-box proteins; physically interacts with Skp1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR258C is not an essential gene 0.091660.41882&radic&radic&radic&radic&radic S000001308MET30YIL046WverifiedF-box protein containing five copies of the WD40 motif,controls cell cycle function, sulfurmetabolism, and methionine biosynthesis as partof the ubiquitin ligase complex; interacts withand regulates Met4p, localizes within thenucleus 0.091180.41762&radic&radic&radic&radic&radic S000005565CKB2YOR039WverifiedBeta' regulatory subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA1, CKA2 and CKB1, the many substratesinclude transcription factors and all RNApolymerases 0.090790.41615&radic&radic&radic S000001297CKA1YIL035CverifiedAlpha catalytic subunit of casein kinase 2, a Ser/Thr proteinkinase with roles in cell growth andproliferation; the holoenzyme also containsCKA2, CKB1 and CKB2, the many substratesinclude transcription factors and all RNApolymerases 0.090740.41615&radic&radic&radic S000000017FUN30YAL019WverifiedProtein whose overexpression affects chromosome stability,potential Cdc28p substrate; homolog of Snf2p;the authentic, non-tagged protein is detectedin highly purified mitochondria inhigh-throughput studies 0.090360.41505&radic&radic&radic S000003367PRE9YGR135Wverified20S proteasome beta-type subunit; the only nonessential 20Ssubunit 0.090210.41458&radic&radic&radic&radic&radic&radic S000002580ARG82YDR173CverifiedInositol polyphosphate multikinase (IPMK), sequentiallyphosphorylates Ins(1,4,5)P3 to formIns(1,3,4,5,6)P5; putative nuclear lipidinositol PI3-kinase; regulates arginine-,phosphate-, and nitrogen-responsive genes 0.090050.41377&radic&radic&radic&radic&radic S000000419HPC2YBR215WverifiedHighly charged, basic protein required for normal cell-cycleregulation of histone gene transcription;mutants display strong synthetic defects withsubunits of FACT, a complex that allows RNA PolII to elongate through nucleosomes 0.090190.41377&radic&radic&radic S000004410CDC73YLR418CverifiedConstituent of Paf1 complex with RNA polymerase II, Paf1p,Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinctfrom Srb-containing Pol II complexes; requiredfor expression of certain genes, modificationof some histones, and telomere maintenance 0.090080.41377&radic&radic&radic S000005133SRP1YNL189WverifiedKaryopherin alpha homolog, forms a dimer with karyopherin betaKap95p to mediate import of nuclear proteins,binds the nuclear localization signal of thesubstrate during import; may also play a rolein regulation of protein degradation 0.089930.41361&radic&radic&radic S000003345DAM1YGR113WverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; Ipl1p target forregulating kinetochore-MT attachments &radic0.089820.41336&radic&radic S000000963SPT2YER161CverifiedProtein involved in negative regulation of transcription;required for RNA polyadenylation; exhibitsregulated interactions with both histones andSWI-SNF components, has similarity to mammalianHMG1 proteins 0.089690.41299&radic&radic&radic S000004732STO1YMR125WverifiedLarge subunit of the nuclear mRNA cap-binding protein complex,interacts with Npl3p to carry nuclear poly(A)+mRNA to cytoplasm; also involved in nuclearmRNA degradation and telomere maintenance;orthologous to mammalian CBP80 0.089740.41299&radic&radic&radic&radic S000005251MCK1YNL307CverifiedProtein serine/threonine/tyrosine (dual-specificity) kinaseinvolved in control of chromosome segregationand in regulating entry into meiosis; relatedto mammalian glycogen synthase kinases of theGSK-3 family 0.089470.41212&radic S000004239YEF3YLR249WverifiedTranslational elongation factor, stimulates the binding ofaminoacyl-tRNA (AA-tRNA) to ribosomes byreleasing EF-1 alpha from the ribosomalcomplex; contains two ABC cassettes; binds andhydrolyses ATP 0.089480.41212&radic&radic S000005642RPO31YOR116CverifiedRNA polymerase III subunit C160, part of core enzyme; similarto bacterial beta-prime subunit 0.089450.4121&radic S000003041HSF1YGL073WverifiedTrimeric heat shock transcription factor, activates multiplegenes in response to stresses that includehyperthermia; recognizes variable heat shockelements (HSEs) consisting of inverted NGAANrepeats; posttranslationally regulated 0.089310.41169&radic&radic&radic&radic&radic&radic S000002482PPH3YDR075WverifiedCatalytic subunit of an evolutionarily conserved proteinphosphatase complex containing Psy2p and theregulatory subunit Psy4p; required forcisplatin resistance; involved in activation ofGln3p 0.088980.41079&radic&radic&radic&radic&radic&radic S000005929CHL1YPL008WverifiedConserved nuclear protein required to establishsister-chromatid pairing during S-phase,probable DNA helicase with similarity to humanBACH1, which associates with tumor suppressorBRCA1; associates with acetyltransferase Ctf7p 0.088770.4098&radic&radic&radic S000004096MDN1YLR106CverifiedHuge dynein-related AAA-type ATPase (midasin), forms extendedpre-60S particle with the Rix1 complex(Rix1p-Ipi1p-Ipi3p), may mediate ATP-dependentremodeling of 60S subunits and subsequentexport from nucleoplasm to cytoplasm 0.088490.40897&radic&radic&radic S000003322UTP22YGR090WuncharacterizedPossible U3 snoRNP protein involved in maturation of pre-18SrRNA, based on computational analysis oflarge-scale protein-protein interaction data 0.088190.40801&radic&radic&radic&radic S000005008YDJ1YNL064CverifiedProtein chaperone involved in regulation of the HSP90 and HSP70functions; involved in protein translocationacross membranes; member of the DnaJ family 0.08820.40801&radic&radic S000001083SRB2YHR041CverifiedGeneral transcription factor, subunit of the RNA polymerase IImediator complex; associates with corepolymerase subunits to form the RNA polymeraseII holoenzyme; involved in telomere maintenance 0.087950.40709&radic&radic&radic&radic S000003295SPT4YGR063CverifiedProtein that forms a complex with Spt5p and mediates bothactivation and inhibition of transcriptionelongation, and plays a role in pre-mRNAprocessing; in addition, Spt4p is involved inkinetochore function and gene silencing &radic0.087950.40709&radic S000005733RET1YOR207CverifiedSecond-largest subunit of RNA polymerase III, which isresponsible for the transcription of tRNA and5S RNA genes, and other low molecular weightRNAs 0.087930.40675&radic S000002840NPL3YDR432WverifiedRNA-binding protein that carries poly(A)+ mRNA from the nucleusinto the cytoplasm; phosphorylation by Sky1p inthe cytoplasm may promote release of mRNAs 0.087920.40675&radic&radic&radic&radic&radic S000003507RTT102YGR275WverifiedComponent of both the SWI/SNF and RSC chromatin remodelingcomplexes, suggested role in chromosomemaintenance; possible weak regulator of Ty1transposition 0.087860.40634&radic&radic&radic&radic&radic S000001930PHO4YFR034CverifiedBasic helix-loop-helix (bHLH) transcription factor; bindscooperatively with Pho2p to the PHO5 promoter;function is regulated by phosphorylation atmultiple sites and by phosphate availability 0.087860.40634&radic&radic&radic S000003412RNR4YGR180CverifiedRibonucleotide-diphosphate reductase (RNR), small subunit; theRNR complex catalyzes the rate-limiting step indNTP synthesis and is regulated by DNAreplication and DNA damage checkpoint pathwaysvia localization of the small subunits 0.087870.40634&radic&radic&radic&radic&radic S000005415PSH1YOL054WuncharacterizedNuclear protein, putative RNA polymerase II elongation factor;isolated as Pob3p/Spt16p-binding protein 0.087750.40559&radic&radic&radic S000004190YKE2YLR200WverifiedSubunit of the heterohexameric Gim/prefoldin protein complexinvolved in the folding of alpha-tubulin,beta-tubulin, and actin 0.087610.40558&radic&radic&radic&radic S000001697YRA2YKL214CverifiedMember of the REF (RNA and export factor binding proteins)family; when overexpressed, can substitute forthe function of Yra1p in export of poly(A)+mRNA from the nucleus 0.087520.40531&radic&radic&radic S000004646MCM1YMR043WverifiedTranscription factor involved in cell-type-specifictranscription and pheromone response; plays acentral role in the formation of both repressorand activator complexes &radic0.087510.40531&radic&radic S000005080EAF7YNL136WverifiedSubunit of the NuA4 histone acetyltransferase complex, whichacetylates the N-terminal tails of histones H4and H2A 0.087370.40472&radic&radic S000000918SLX8YER116CverifiedProtein containing a RING finger domain that interacts withHex3p; mutant phenotypes and geneticinteractions suggest a role in sumoylation andin genome stability 0.087280.40428&radic&radic S000005945RMI1YPL024WverifiedInvolved in response to DNA damage; null mutants have increasedrates of recombination and delayed S phase;interacts physically and genetically with Sgs1p(RecQ family member) and Top3p (topoisomeraseIII) 0.087110.40378&radic&radic S000002211PBP4YDL053CverifiedPbp1p binding protein, interacts strongly with Pab1p-bindingprotein 1 (Pbp1p) in the yeast two-hybridsystem; also interacts with Lsm12p in acopurification assay 0.087150.40378&radic&radic S000005559EXO1YOR033Cverified5'-3' exonuclease and flap-endonuclease involved inrecombination, double-strand break repair andDNA mismatch repair; member of the Rad2pnuclease family, with conserved N and Inuclease domains 0.086950.40343&radic&radic&radic&radic S000006014NOG1YPL093WverifiedPutative GTPase that associates with free 60S ribosomalsubunits in the nucleolus and is required for60S ribosomal subunit biogenesis; constituentof 66S pre-ribosomal particles; member of theODN family of nucleolar G-proteins 0.086860.40306&radic&radic S000003039AFT1YGL071WverifiedTranscription factor involved in iron utilization andhomeostasis; binds the consensus sitePyPuCACCCPu and activates the expression oftarget genes in response to changes in ironavailability 0.086870.40306&radic&radic&radic&radic&radic&radic S000000009SWC3YAL011WverifiedProtein of unknown function, component of the SWR1 complex,which exchanges histone variant H2AZ (Htz1p)for chromatin-bound histone H2A; required forformation of nuclear-associated array of smoothendoplasmic reticulum known as karmellae 0.086910.40306&radic&radic&radic S000003424TDH3YGR192CverifiedGlyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involvedin glycolysis and gluconeogenesis; tetramerthat catalyzes the reaction ofglyceraldehyde-3-phosphate to 1,3bis-phosphoglycerate; detected in the cytoplasmand cell-wall 0.086720.40227&radic&radic&radic S000002743MSN5YDR335WverifiedKaryopherin involved in nuclear import and export; shown to beresponsible for nuclear import of replicationprotein A and for export of several proteinsincluding Swi6p, Far1p, and Pho4p; cargodissociation involves binding to RanGTP 0.086790.40227&radic&radic&radic&radic&radic S000000935GLC7YER133WverifiedCatalytic subunit of type 1 serine/threonine proteinphosphatase, involved in many processesincluding glycogen metabolism, sporulation, andmitosis; interacts with multiple regulatorysubunits; predominantly isolated with Sds22p 0.086730.40227&radic&radic S000005068NAF1YNL124WverifiedProtein required for the assembly of box H/ACA snoRNPs and forpre-rRNA processing, forms a complex with Shq1pand interacts with H/ACA snoRNP componentsNhp2p and Cbf5p; has similarity to Gar1p andother RNA-binding proteins 0.086620.40209&radic S000000154SHP1YBL058WverifiedUBX (ubiquitin regulatory X) domain-containing protein thatregulates Glc7p phosphatase activity andinteracts with Cdc48p; interacts withubiquitylated proteins in vivo and is requiredfor degradation of a ubiquitylated modelsubstrate 0.086580.40168&radic&radic&radic&radic&radic S000002217RAD59YDL059CverifiedProtein involved in the repair of double-strand breaks in DNAduring vegetative growth via recombination andsingle-strand annealing; anneals complementarysingle-stranded DNA; homologous to Rad52p 0.086520.40128&radic&radic&radic&radic&radic S000007230YCR018C-ADubiousPutative protein of unknown function; encoded opposite a Ty1 LTR 0.086510.40128&radic S000002904PUF6YDR496CverifiedPumilio-homology domain protein that binds ASH1 mRNA at PUFconsensus sequences in the 3' UTR and repressesits translation, resulting in proper asymmetriclocalization of ASH1 mRNA 0.08650.40128&radic S000003358YGR126WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 0.086270.40039&radic&radic&radic&radic S000000944MAG1YER142Cverified3-methyl-adenine DNA glycosylase involved in protecting DNAagainst alkylating agents; initiates baseexcision repair by removing damaged bases tocreate abasic sites that are subsequentlyrepaired 0.086110.40004&radic&radic S000005590YNG1YOR064CverifiedSubunit of the NuA3 histone acetyltransferase complex thatacetylates histone H3; has similarity to thehuman tumor suppressor ING1 &radic0.085820.39912&radic&radic&radic&radic S000006238ARP7YPR034WverifiedActin-related protein involved in transcriptional regulation;subunit of the chromatin remodeling Snf/Swicomplex 0.08570.39886&radic S000004172SWI6YLR182WverifiedTranscription cofactor, forms complexes with DNA-bindingproteins Swi4p and Mbp1p to regulatetranscription at the G1/S transition; involvedin meiotic gene expression; localizationregulated by phosphorylation; potential Cdc28psubstrate 0.085140.39647&radic&radic&radic&radic S000001014SPO11YHL022CverifiedMeiosis-specific protein that initiates meiotic recombinationby catalyzing the formation of double-strandbreaks in DNA via a transesterificationreaction; required for homologous chromosomepairing and synaptonemal complex formation 0.084980.39617&radic&radic&radic&radic S000006049TBF1YPL128CverifiedTelobox-containing general regulatory factor; binds to TTAGGGrepeats within subtelomeric anti-silencingregions (STARs) and possibly throughout thegenome and mediates their insulating capacityby blocking silent chromatin propagation &radic0.084840.39598&radic&radic&radic S000002847LRS4YDR439WverifiedProtein involved in rDNA silencing; positively chargedcoiled-coil protein with limited similarity tomyosin &radic0.084830.39598&radic&radic S000004445RIF2YLR453CverifiedProtein that binds to the Rap1p C-terminus and actssynergistically with Rif1p to help controltelomere length and establish telomericsilencing; deletion results in telomereelongation &radic0.084870.39598&radic S000000142PSY4YBL046WverifiedPutative regulatory subunit of an evolutionarily conservedprotein phosphatase complex containing thecatalytic subunit Pph3p and a third subunitPsy2p; required for cisplatin resistance;GFP-fusion protein localizes to the nucleus 0.08460.39481&radic S000001141TRA1YHR099WverifiedSubunit of SAGA and NuA4 histone acetyltransferase complexes;interacts with acidic activators (e.g., Gal4p)which leads to transcription activation;similar to human TRRAP, which is a cofactor forc-Myc mediated oncogenic transformation 0.084580.39481 S000003038RPB9YGL070CverifiedRNA polymerase II subunit B12.6; contacts DNA; mutations affecttranscription start site; involved in telomeremaintenance 0.084470.39438&radic&radic&radic S000002824SYF1YDR416WverifiedComponent of the spliceosome complex involved in pre-mRNAsplicing; involved in regulation of cell cycleprogression; similar to Drosophila crooked neckprotein 0.084450.39438&radic&radic&radic&radic S000003704SET2YJL168CverifiedHistone methyltransferase with a role in transcriptionalelongation, methylates a lysine residue ofhistone H3; associates with the C-terminaldomain of Rpo21p; histone methylation activityis regulated by phosphorylation status ofRpo21p 0.083990.39313&radic&radic&radic&radic&radic S000001073RRM3YHR031CverifiedDNA helicase involved in rDNA replication and Ty1transposition; relieves replication fork pausesat telomeric regions; structurally andfunctionally related to Pif1p &radic0.083920.3931&radic&radic S000004711PGM2YMR105CverifiedPhosphoglucomutase, catalyzes the conversion fromglucose-1-phosphate to glucose-6-phosphate,which is a key step in hexose metabolism;functions as the acceptor for aGlc-phosphotransferase 0.083770.39261&radic&radic S000005026PMS1YNL082WverifiedATP-binding protein required for mismatch repair in mitosis andmeiosis; functions as a heterodimer with Mlh1p,binds double- and single-stranded DNA via itsN-terminal domain, similar to E. coli MutL 0.083140.39016&radic&radic S000000030PRP45YAL032CverifiedProtein required for pre-mRNA splicing; associates with thespliceosome and interacts with splicing factorsPrp22p and Prp46p; orthologous to humantranscriptional coactivator SKIP and canactivate transcription of a reporter gene 0.083010.38964&radic&radic S000005506PSF3YOL146WverifiedSubunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), whichis localized to DNA replication origins andimplicated in assembly of the DNA replicationmachinery &radic0.082890.3896&radic&radic S000003054MAD1YGL086WverifiedCoiled-coil protein involved in the spindle-assemblycheckpoint; phosphorylated by Mps1p uponcheckpoint activation which leads to inhibitionof the activity of the anaphase promotingcomplex; forms a complex with Mad2p 0.082870.38946&radic&radic S000004647IOC4YMR044WverifiedMember of a complex (Isw1b) with Isw1p and Ioc2p that exhibitsnucleosome-stimulated ATPase activity and actswithin coding regions to coordinatetranscription elongation with termination andprocessing, contains a PWWP motif 0.082810.3893&radic&radic&radic S000004897YKU70YMR284WverifiedSubunit of the telomeric Ku complex (Yku70p-Yku80p), involvedin telomere length maintenance, structure andtelomere position effect; relocates to sites ofdouble-strand cleavage to promote nonhomologousend joining during DSB repair &radic0.082320.38772&radic S000004847RNH1YMR234WverifiedRibonuclease H1, removes RNA primers during Okazaki fragmentsynthesis; degrades RNA attached to the 5'-endof a DNA strand 0.082280.38772&radic&radic&radic&radic S000000894IES5YER092WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.082310.38772&radic S000004839TMA29YMR226CverifiedNADP(+)-dependent dehydrogenase; acts on serine,L-allo-threonine, and other 3-hydroxy acids;green fluorescent protein fusion proteinlocalizes to the cytoplasm and nucleus; mayinteract with ribosomes, based onco-purification experiments 0.082190.38747&radic&radic S000002562CPR1YDR155CverifiedCytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin),catalyzes the cis-trans isomerization ofpeptide bonds N-terminal to proline residues;binds the drug cyclosporin A 0.08210.38728&radic&radic&radic&radic S000005952PHO85YPL031CverifiedCyclin-dependent kinase, with ten cyclin partners; involved inenvironmental stress response; inphosphate-rich conditions, Pho85p-Pho80pcomplex phosphorylates Pho4p which in turnrepresses PHO5 0.082090.38728&radic&radic&radic S000005336NOG2YNR053CverifiedPutative GTPase that associates with pre-60S ribosomal subunitsin the nucleolus and is required for theirnuclear export and maturation 0.082070.38698&radic S000001161SET1YHR119WverifiedHistone methyltransferase, subunit of the COMPASS (Set1C)complex which methylates histone H3 on lysine4; required in transcriptional silencing neartelomeres and at the silent mating type loci;contains a SET domain 0.081940.3865&radic&radic S000000914LSM4YER112WverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.081770.3858&radic&radic&radic S000003095SOH1YGL127CverifiedSubunit of the RNA polymerase II mediator complex; associateswith core polymerase subunits to form the RNApolymerase II holoenzyme; involved in telomeremaintenance; conserved with other metazoanMED31 subunits 0.081470.38518&radic&radic S000005551HST3YOR025WverifiedMember of the Sir2 family of NAD(+)-dependent proteindeacetylases; involved along with Hst4p intelomeric silencing, cell cycle progression,radiation resistance, genomic stability andshort-chain fatty acid metabolism 0.081520.38517&radic&radic&radic&radic&radic&radic S000004523SML1YML058WverifiedRibonucleotide reductase inhibitor involved in regulating dNTPproduction; regulated by Mec1p and Rad53pduring DNA damage and S phase 0.081550.38517&radic&radic&radic S000004012SDO1YLR022CuncharacterizedEssential protein involved in RNA metabolism, one of two yeasthomologs (with Yhr087wp) of the human proteinSBDS responsible for autosomal recessiveShwachman-Bodian-Diamond Syndrome, alsoconserved in Archaea 0.081290.38475&radic&radic&radic&radic S000004826CEF1YMR213WverifiedEssential splicing factor; associated with Prp19p and thespliceosome, contains an N-terminal c-Myb DNAbinding motif necessary for cell viability butnot for Prp19p association, evolutionarilyconserved and homologous to S. pombe Cdc5p 0.081220.38429&radic&radic&radic S000002341LYS20YDL182WverifiedHomocitrate synthase isozyme, catalyzes the condensation ofacetyl-CoA and alpha-ketoglutarate to formhomocitrate, which is the first step in thelysine biosynthesis pathway; highly similar tothe other isozyme, Lys21p 0.081070.3838&radic&radic&radic S000003563RNR2YJL026WverifiedRibonucleotide-diphosphate reductase (RNR), small subunit; theRNR complex catalyzes the rate-limiting step indNTP synthesis and is regulated by DNAreplication and DNA damage checkpoint pathwaysvia localization of the small subunits 0.08110.3838&radic&radic&radic S000003957RIX7YLL034CverifiedPutative ATPase of the AAA family, required for export ofpre-ribosomal large subunits from the nucleus;distributed between the nucleolus, nucleoplasm,and nuclear periphery depending on growthconditions 0.081120.3838&radic&radic&radic S000005627RAS1YOR101WverifiedGTPase involved in G-protein signaling in the adenylate cyclaseactivating pathway, plays a role in cellproliferation; localized to the plasmamembrane; homolog of mammalian RASproto-oncogenes 0.080970.38347&radic S000000364CDC28YBR160WverifiedCatalytic subunit of the main cell cycle cyclin-dependentkinase (CDK); alternately associates with G1cyclins (CLNs) and G2/M cyclins (CLBs) whichdirect the CDK to specific substrates 0.080910.38312&radic&radic S000003612NET1YJL076WverifiedCore subunit of the RENT complex, which is a complex involvedin nucleolar silencing and telophase exit;stimulates transcription by RNA polymerase Iand regulates nucleolar structure 0.08090.38312 S000002893VPS72YDR485CverifiedHtz1p-binding component of the SWR1 complex, which exchangeshistone variant H2AZ (Htz1p) forchromatin-bound histone H2A; required forvacuolar protein sorting 0.080910.38312&radic&radic S000004876SAP30YMR263WverifiedSubunit of a histone deacetylase complex, along with Rpd3p andSin3p, that is involved in silencing attelomeres, rDNA, and silent mating-type loci;involved in telomere maintenance 0.080940.38312&radic&radic&radic S000004045SPT8YLR055CverifiedSubunit of the SAGA transcriptional regulatory complex but notpresent in SAGA-like complex SLIK/SALSA,required for SAGA-mediated inhibition at somepromoters 0.080790.38287&radic&radic&radic S000001210THP2YHR167WverifiedSubunit of the THO complex, which connects transcriptionelongation and mitotic recombination, and ofthe TREX complex, which is recruited toactivated genes and couples transcription tomRNA export; involved in telomere maintenance 0.080710.38248&radic&radic&radic&radic S000002205SIT4YDL047WverifiedType 2A-related serine-threonine phosphatase that functions inthe G1/S transition of the mitotic cycle;cytoplasmic and nuclear protein that modulatesfunctions mediated by Pkc1p including cell walland actin cytoskeleton organization 0.080210.38063&radic&radic&radic S000002232BRE1YDL074CverifiedE3 ubiquitin ligase for Rad6p, required for the ubiquitinationof histone H2B, recruitment of Rad6p topromoter chromatin and subsequent methylationof histone H3 (on L4 and L79), contains RINGfinger domain 0.080230.38063&radic&radic S000003131RAD54YGL163CverifiedDNA-dependent ATPase, stimulates strand exchange by modifyingthe topology of double-stranded DNA; involvedin the recombinational repair of double-strandbreaks in DNA during vegetative growth andmeiosis; member of the SWI/SNF family 0.080120.38007&radic&radic S000004313SFH1YLR321CverifiedSubunit of the RSC chromatin remodeling complex required forkinetochore function in chromosome segregation;essential gene required for cell cycleprogression; phosphorylated in the G1 phase ofthe cell cycle; Snf5p paralog 0.080150.38007&radic&radic&radic&radic S000000253REB1YBR049CverifiedRNA polymerase I enhancer binding protein; DNA binding proteinwhich binds to genes transcribed by both RNApolymerase I and RNA polymerase II; requiredfor termination of RNA polymerase Itranscription 0.08010.38007&radic&radic S000006373JIP5YPR169WuncharacterizedNucleolar protein of unknown function, exhibits a physicalinteraction with Bre1p 0.080060.3791&radic&radic&radic&radic S000005636TFC7YOR110WverifiedOne of six subunits of the RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part of theTauA globular domain of TFIIIC that binds DNAat the BoxA promoter sites of tRNA and similargenes 0.079980.3791&radic&radic&radic S000003209DOC1YGL240WverifiedProcessivity factor required for the ubiquitination activity ofthe anaphase promoting complex (APC), mediatesthe activity of the APC by contributing tosubstrate recognition; involved in cyclinproteolysis 0.079790.37876&radic&radic&radic S000001393FKH1YIL131CverifiedForkhead family transcription factor with a minor role in theexpression of G2/M phase genes; negativelyregulates transcriptional elongation; positiverole in chromatin silencing at HML and HMR;regulates donor preference during switching 0.079810.37876&radic S000004840TAF7YMR227CverifiedTFIID subunit (67 kDa), involved in RNA polymerase IItranscription initiation 0.079560.37813&radic&radic&radic&radic&radic&radic S000000808NUG1YER006WverifiedGTPase that associates with nuclear 60S pre-ribosomes, requiredfor export of 60S ribosomal subunits from thenucleus 0.079470.37691&radic&radic&radic S000002451HEM13YDR044WverifiedCoproporphyrinogen III oxidase, an oxygen requiring enzyme thatcatalyzes the sixth step in the hemebiosynthetic pathway; localizes to themitochondrial inner membrane; transcription isrepressed by oxygen and heme (via Rox1p andHap1p) 0.07860.37391&radic&radic S000003769TDH2YJR009CverifiedGlyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involvedin glycolysis and gluconeogenesis; tetramerthat catalyzes the reaction ofglyceraldehyde-3-phosphate to 1,3bis-phosphoglycerate; detected in the cytoplasmand cell-wall 0.07880.37391&radic&radic S000003034SGF73YGL066Wverified73 kDa subunit of SAGA histone acetyltransferase complex;involved in formation of the preinitiationcomplex assembly at promoters 0.07850.37391&radic&radic&radic&radic S000005887PDE2YOR360CverifiedHigh-affinity cyclic AMP phosphodiesterase, component of thecAMP-dependent protein kinase signaling system,protects the cell from extracellular cAMP,contains readthrough motif surroundingtermination codon 0.078020.37284&radic&radic&radic S000004697NPL6YMR091CverifiedComponent of the RSC chromatin remodeling complex; interactswith Rsc3p, Rsc30p, Ldb7p, and Htl1p to form amodule important for a broad range of RSCfunctions; involved in nuclear protein importand maintenance of proper telomere length 0.078070.37284&radic&radic&radic&radic S000000189ROX3YBL093CverifiedRNA polymerase II holoenzyme component 0.077880.37189&radic&radic&radic&radic S000002201PRP11YDL043CverifiedSubunit of the SF3a splicing factor complex, required forspliceosome assembly 0.0780.37189&radic&radic S000005943RAD1YPL022WverifiedSingle-stranded DNA endonuclease (with Rad10p), cleavessingle-stranded DNA during nucleotide excisionrepair and double-strand break repair; subunitof Nucleotide Excision Repair Factor 1 (NEF1);homolog of human XPF protein 0.077820.37189&radic S000001895DEG1YFL001WverifiedNon-essential tRNA:pseudouridine synthase, introducespseudouridines at position 38 or 39 in tRNA,important for maintenance of translationefficiency and normal cell growth, localizes toboth the nucleus and cytoplasm 0.077720.37085&radic&radic S000004339KAP95YLR347CverifiedKaryopherin beta, forms a dimeric complex with Srp1p (Kap60p)that mediates nuclear import of cargo proteinsvia a nuclear localization signal (NLS),interacts with nucleoporins to guide transportacross the nuclear pore complex 0.077760.37085&radic&radic S000003925RTT109YLL002WverifiedProtein with a role in regulation of Ty1 transposition 0.077460.37064&radic&radic&radic&radic&radic S000002421RAD61YDR014WverifiedProtein of unknown function; mutation confers radiationsensitivity 0.077340.37039&radic&radic S000003811ISY1YJR050WverifiedComponent of the spliceosome complex involved in pre-mRNAsplicing, auxiliary splicing factor that maymodulate Syf1p activity and help optimizesplicing; isy1 syf2 double mutation activatesthe spindle checkpoint, causing cell cyclearrest 0.07730.3701&radic&radic S000003865SOD1YJR104CverifiedCytosolic superoxide dismutase; some mutations are analogous tothose that cause ALS (amyotrophic lateralsclerosis) in humans 0.077250.3701&radic&radic&radic S000005976LGE1YPL055CverifiedProtein of unknown function; null mutant forms abnormally largecells 0.07720.36988&radic&radic S000000752SNU13YEL026WverifiedRNA binding protein, part of U3 snoRNP involved in rRNAprocessing, part of U4/U6-U5 tri-snRNP involvedin mRNA splicing, similar to human 15.5Kprotein 0.077180.36988&radic&radic&radic&radic S000004069SIC1YLR079WverifiedInhibitor of Cdc28-Clb kinase complexes that controls G1/Sphase transition, preventing premature S phaseand ensuring genomic integrity; phosphorylationtargets Sic1p for SCF(CDC4)-dependent turnover;functional homolog of mammalian Kip1 0.077140.36961&radic&radic&radic&radic S000000379SWD3YBR175WverifiedEssential subunit of the COMPASS (Set1C) complex, whichmethylates histone H3 on lysine 4 and isrequired in transcriptional silencing neartelomeres; WD40 beta propeller superfamilymember and ortholog of mammalian WDR5 0.077080.36939&radic&radic&radic&radic S000004641CCS1YMR038CverifiedCopper chaperone for superoxide dismutase Sod1p, involved inoxidative stress protection; Met-X-Cys-X2-Cysmotif within the N-terminal portion is involvedin insertion of copper into Sod1p underconditions of copper deprivation 0.076770.36838&radic&radic&radic&radic&radic S000000682CSM1YCR086WverifiedNucleolar protein that forms a complex with Lrs4p which bindsMam1p at kinetochores during meiosis I tomediate accurate chromosome segregation, may beinvolved in premeiotic DNA replication;possible role in telomere maintenance &radic0.076720.36835&radic&radic&radic S000003807TAH11YJR046WverifiedDNA replication licensing factor, required for pre-replicationcomplex assembly 0.076690.36827&radic&radic&radic S000028421HSK3YKL138C-AverifiedEssential subunit of the Dam1 complex (aka DASH complex),couples kinetochores to the force produced byMT depolymerization thereby aiding inchromosome segregation; is transferred to thekinetochore prior to mitosis &radic0.076650.36827 S000005711GSP2YOR185CverifiedGTP binding protein (mammalian Ranp homolog) involved in themaintenance of nuclear organization, RNAprocessing and transport; interacts withKap121p, Kap123p and Pdr6p (karyophilin betas);Gsp1p homolog that is not required forviability 0.076590.36745&radic&radic&radic&radic S000005047MET4YNL103WverifiedLecine-zipper transcriptional activator, responsible for theregulation of the sulfur amino acid pathway,requires different combinations of theauxiliary factors Cbf1p, Met28p, Met31p andMet32p 0.076140.36576&radic&radic&radic S000001693UBA1YKL210WverifiedUbiquitin activating enzyme, involved in ubiquitin-mediatedprotein degradation and essential for viability 0.076270.36576&radic&radic S000001126STE12YHR084WverifiedTranscription factor that is activated by a MAP kinasesignaling cascade, activates genes involved inmating or pseudohyphal/invasive growthpathways; cooperates with Tec1p transcriptionfactor to regulate genes specific for invasivegrowth 0.07620.36576&radic S000005476MSN1YOL116WverifiedTranscriptional activator involved in regulation of invertaseand glucoamylase expression, invasive growthand pseudohyphal differentiation, iron uptake,chromium accumulation, and response to osmoticstress; localizes to the nucleus 0.076220.36576&radic S000002273IWR1YDL115CuncharacterizedProtein of unknown function, deletion causes hypersensitivityto the K1 killer toxin 0.075940.36515&radic&radic&radic S000004966HDA1YNL021WverifiedPutative catalytic subunit of a class II histone deacetylasecomplex that also contains Hda2p and Hda3p;Hda1p interacts with the Hda2p-Hda3p subcomplexto form an active tetramer; deletion increaseshistone H2B, H3 and H4 acetylation 0.075820.36496&radic&radic&radic S000004700CTF13YMR094WverifiedSubunit of the CBF3 complex, which binds to the CDE III elementof centromeres, bending the DNA upon binding,and may be involved in sister chromatidcohesion during mitosis &radic0.07580.36496&radic&radic S000002773ESF1YDR365CverifiedNucleolar protein involved in pre-rRNA processing; depletioncauses severely decreased 18S rRNA levels 0.075870.36496&radic&radic&radic&radic&radic S000000451ENP1YBR247CverifiedProtein associated with U3 and U14 snoRNAs, required forpre-rRNA processing and 40S ribosomal subunitsynthesis; localized in the nucleus andconcentrated in the nucleolus 0.075740.36388&radic&radic S000003306SMD1YGR074WverifiedCore Sm protein Sm D1; part of heteroheptameric complex (withSmb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm D1 0.075750.36388&radic&radic&radic&radic S000001537DEF1YKL054CverifiedRNAPII degradation factor, forms a complex with Rad26p inchromatin, enables ubiquitination andproteolysis of RNAPII present in an elongationcomplex 0.075650.36388&radic&radic S000005996GCR1YPL075WverifiedTranscriptional activator of genes involved in glycolysis;DNA-binding protein that interacts andfunctions with the transcriptional activatorGcr2p 0.07560.36388&radic&radic&radic S000003256THG1YGR024CverifiedtRNAHis guanylyltransferase, adds a guanosine residue to the 5'end of tRNAHis after transcription and RNase Pcleavage; couples nuclear division andmigration to cell budding and cytokinesis;essential enzyme conserved among eukaryotes 0.075610.36388&radic&radic S000000063NUP60YAR002WverifiedSubunit of the nuclear pore complex (NPC), functions to anchorNup2p to the NPC in a process controlled by thenucleoplasmic concentration of Gsp1p-GTP;potential Cdc28p substrate; involved intelomere maintenance 0.075460.3635&radic&radic&radic&radic S000003543CTK2YJL006CverifiedBeta subunit of C-terminal domain kinase I (CTDK-I), whichphosphorylates the C-terminal repeated domainof the RNA polymerase II large subunit (Rpo21p)to affect both transcription and pre-mRNA 3'end processing; has similarity to cyclins 0.075330.36343&radic S000005677RPB2YOR151CverifiedRNA polymerase II second largest subunit B150, part of centralcore; similar to bacterial beta subunit 0.074950.36151&radic&radic&radic&radic&radic S000002615UME6YDR207CverifiedKey transcriptional regulator of early meiotic genes, bindsURS1 upstream regulatory sequence, couplesmetabolic responses to nutritional cues withinitiation and progression of meiosis, formscomplex with Ime1p, and also with Sin3p-Rpd3p 0.0750.36151&radic&radic&radic&radic&radic&radic&radic S000004525OGG1YML060WverifiedMitochondrial glycosylase/lyase that specifically excises7,8-dihydro-8-oxoguanine residues locatedopposite cytosine or thymine residues in DNA,repairs oxidative damage to mitochondrial DNA 0.074770.36138&radic&radic&radic S000002178RPN4YDL020CverifiedTranscription factor that stimulates expression of proteasomegenes; Rpn4p levels are in turn regulated bythe 26S proteasome in a negative feedbackcontrol mechanism; RPN4 is transcriptionallyregulated by various stress responses 0.074680.3611&radic S000006132NIP7YPL211WverifiedNucleolar protein required for 60S ribosome subunit biogenesis,constituent of 66S pre-ribosomal particles;physically interacts with Nop8p and the exosomesubunit Rrp43p 0.074680.3611&radic&radic&radic&radic&radic S000000221KAP104YBR017CverifiedTransportin, cytosolic karyopherin beta 2 involved in deliveryof heterogeneous nuclear ribonucleoproteins tothe nucleoplasm, binds rg-nuclear localizationsignals on Nab2p and Hrp1p, plays a role incell-cycle progression 0.07430.35912&radic S000000120NCL1YBL024WverifiedS-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase,methylates cytosine to m5C at several positionsin tRNAs and intron-containing pre-tRNAs;similar to Nop2p and human proliferationassociated nucleolar protein p120 0.074110.35901&radic&radic S000004042IES3YLR052WverifiedSubunit of the INO80 chromatin remodeling complex 0.074050.35876&radic S000003207CSE1YGL238WverifiedNuclear envelope protein that mediates the nuclear export ofimportin alpha (Srp1p), homolog of metazoan CASprotein, required for accurate chromosomesegregation 0.073980.35856&radic&radic&radic&radic&radic S000001283RPB3YIL021WverifiedRNA polymerase II third largest subunit B44, part of centralcore; similar to prokaryotic alpha subunit 0.073970.35853&radic&radic S000005895RAD17YOR368WverifiedCheckpoint protein, involved in the activation of the DNAdamage and meiotic pachytene checkpoints; withMec3p and Ddc1p, forms a clamp that is loadedonto partial duplex DNA; homolog of human andS. pombe Rad1 and U. maydis Rec1 proteins 0.073920.35837&radic&radic&radic&radic&radic&radic S000000437PBP2YBR233WverifiedRNA binding protein with similarity to mammalian heterogeneousnuclear RNP K protein, involved in theregulation of telomere position effect andtelomere length 0.073910.35837&radic S000002872SPP41YDR464WverifiedProtein involved in negative regulation of expression ofspliceosome components PRP4 and PRP3 0.07380.3581&radic&radic&radic S000006166YPL245WUncharacterizedHypothetical protein 0.073780.3581&radic S000002574TAF10YDR167WverifiedSubunit (145 kDa) of TFIID and SAGA complexes, involved in RNApolymerase II transcription initiation and inchromatin modification 0.07380.3581&radic&radic&radic&radic S000005429HST1YOL068CverifiedNAD(+)-dependent histone deacetylase; essential subunit of theSum1p/Rfm1p/Hst1p complex required forORC-dependent silencing and mitotic repression;non-essential subunit of the Set3C deacetylasecomplex; involved in telomere maintenance 0.07370.35786&radic&radic&radic S000004216BUR2YLR226WverifiedCyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2pcomprise a CDK-cyclin complex involved intranscriptional regulation through itsphosphorylation of the carboxy-terminal domainof the largest subunit of RNA polymerase II 0.073640.35756&radic&radic&radic&radic S000001456MET28YIR017CverifiedTranscriptional activator in the Cbf1p-Met4p-Met28p complex,participates in the regulation of sulfurmetabolism 0.073590.35708&radic&radic&radic S000000025YAL027WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YAL027W is a non-essential gene 0.073560.35708&radic&radic&radic&radic&radic S000004268YLR278CUncharacterizedZinc-cluster protein; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; YLR278C is not an essential gene 0.073470.35641&radic&radic&radic&radic S000001932CDC26YFR036WverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 0.073450.35641&radic&radic&radic&radic S000000770IES6YEL044WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.073380.35641&radic&radic&radic&radic S000002772CDC40YDR364CverifiedPre-mRNA splicing factor, important for catalytic step II ofpre-mRNA splicing and plays a role in cellcycle progression; required for DNA synthesisduring mitosis and meiosis; has WD repeats 0.073070.35527&radic&radic&radic S000001240RIX1YHR197WverifiedEssential protein involved in the processing of the ITS2 regionof the rRNA locus; required for the maturationand nuclear export of the 60S ribosomal subunit 0.072990.35493&radic&radic S000004107CLF1YLR117CverifiedEssential splicesome assembly factor; contains multipletetratricopeptide repeat (TPR) protein-bindingmotifs and interacts specifically with manyspliceosome components, may serve as a scaffoldduring splicesome assembly &radic0.072970.35493&radic&radic&radic S000002520PDS1YDR113CverifiedSecurin that inhibits anaphase by binding separin Esp1p, alsoblocks cyclin destruction and mitotic exit,essential for cell cycle arrest in mitosis inthe presence of DNA damage or aberrant mitoticspindles; also present in meiotic nuclei 0.072910.35444&radic&radic&radic&radic S000004539FPR3YML074CverifiedNucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506binding protein; phosphorylated by caseinkinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) anddephosphorylated by Ptp1p 0.07260.3536&radic S000006290SUA7YPR086WverifiedTranscription factor TFIIB, a general transcription factorrequired for transcription initiation and startsite selection by RNA polymerase II 0.072530.35331&radic&radic&radic S000000117HAP3YBL021CverifiedSubunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5pCCAAT-binding complex, a transcriptionalactivator and global regulator of respiratorygene expression; contains sequencescontributing to both complex assembly and DNAbinding 0.072550.35331&radic&radic&radic&radic S000000973RAD3YER171Wverified5' to 3' DNA helicase, involved in nucleotide excision repairand transcription; subunit of RNA polymerase IItranscription initiation factor TFIIH; subunitof Nucleotide Excision Repair Factor 3 (NEF3);homolog of human XPD protein 0.072410.35302&radic S000003510CWC22YGR278WverifiedEssential protein, component of a complex containing Cef1p, hassimilarity to S. pombe Cwf22p; putativespliceosomal component, based on computationalanalysis of large-scale protein-proteininteraction data 0.072290.35241&radic&radic&radic&radic S000002703HDA2YDR295CverifiedSubunit of a possibly tetrameric trichostatin A-sensitive classII histone deacetylase complex containing anHda1p homodimer and an Hda2p-Hda3p heterodimer;involved in telomere maintenance 0.072110.35089&radic&radic&radic&radic&radic S000006072PRP46YPL151CverifiedSplicing factor that is found in the Cef1p subcomplex of thespliceosome 0.072230.35089&radic&radic&radic S000001346SDS3YIL084CverifiedComponent of the Rpd3p/Sin3p deacetylase complex required forits structural integrity and catalyticactivity, involved in transcriptional silencingand required for sporulation; cells defectivein SDS3 display pleiotropic phenotypes 0.071920.35036&radic&radic&radic&radic S000000840KRE29YER038CverifiedEssential subunit of the Mms21-Smc5-Smc6 complex; protein ofunknown function; required for growth and DNArepair; heterozygous mutant showshaploinsufficiency in K1 killer toxinresistance &radic0.071830.35031&radic&radic S000004665RNA14YMR061WverifiedCleavage and polyadenylation factor I (CF I) component involvedin cleavage and polyadenylation of mRNA 3'ends; bridges interaction between Rna15p andHrp1p in the CF I complex 0.071720.34987&radic S000003330ESP1YGR098CverifiedSeparase with cysteine protease activity (related to caspases)that promotes sister chromatid separation bymediating dissociation of the cohesin Scc1pfrom chromatin; inhibited by Pds1p 0.071750.34987&radic&radic&radic S000001337RPN2YIL075CverifiedSubunit of the 26S proteasome, substrate of theN-acetyltransferase Nat1p 0.071460.34859&radic&radic&radic S000004237IRC20YLR247CuncharacterizedPutative helicase; localized to mitochondria and the nucleus;YLR247C is not an essential gene; null mutantdisplays increased levels of spontaneous Rad52foci 0.071540.34859&radic&radic&radic&radic S000003485PUP2YGR253CverifiedAlpha subunit of the 20S proteasome involved inubiquitin-dependent catabolism; human homologis subunit zeta 0.071410.34859&radic&radic&radic S000000533RNQ1YCL028Wverified[PIN(+)] prion, an infectious protein conformation that isgenerally an ordered protein aggregate 0.071470.34859&radic&radic&radic&radic S000001696DOA1YKL213CverifiedWD repeat protein required for ubiquitin-mediated proteindegradation, forms complex with Cdc48p, plays arole in controlling cellular ubiquitinconcentration; also promotes efficient NHEJ inpostdiauxic/stationary phase 0.071170.3482&radic&radic&radic S000001072SLT2YHR030CverifiedSerine/threonine MAP kinase involved in regulating themaintenance of cell wall integrity andprogression through the cell cycle; regulatedby the PKC1-mediated signaling pathway 0.07120.3482&radic&radic&radic S000005293CSE2YNR010WverifiedComponent of the Med9/10 module, which is a subcomplex withinthe RNA polymerase II Mediator complex;required for regulation of RNA polymerase IIactivity 0.071090.3478&radic&radic S000005159IES2YNL215WverifiedProtein that associates with the INO80 chromatin remodelingcomplex under low-salt conditions 0.071090.3478&radic&radic&radic&radic&radic S000000323MUD1YBR119WverifiedU1 snRNP A protein, homolog of human U1-A; involved in nuclearmRNA splicing 0.071130.3478&radic&radic&radic&radic&radic S000004949HRB1YNL004WverifiedPoly(A+) RNA-binding protein, involved in the export of mRNAsfrom the nucleus to the cytoplasm; similar toGbp2p and Npl3p 0.070790.3461&radic S000005119NOP13YNL175CverifiedProtein of unknown function, localizes to the nucleolus andnucleoplasm; contains an RNA recognition motif(RRM) and has similarity to Nop12p, which isrequired for processing of pre-18S rRNA 0.070910.3461&radic&radic&radic&radic S000003099SNT2YGL131CverifiedDNA binding protein with similarity to the S. pombe Snt2protein 0.070770.3461&radic&radic S000002651PRP28YDR243CverifiedRNA helicase in the DEAD-box family, involved in RNAisomerization at the 5' splice site 0.071010.3461&radic&radic&radic&radic S000001325YRB2YIL063CverifiedProtein of unknown function involved in nuclear processes ofthe Ran-GTPase cycle; involved in nuclearprotein export; contains Ran Binding Domain andFxFG repeats; interacts with Srm1p, GTP-Gsp1p,Rna1p and Crm1p; is not essential 0.071010.3461&radic&radic S000002420PSF1YDR013WverifiedSubunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), whichis localized to DNA replication origins andimplicated in assembly of the DNA replicationmachinery &radic0.070740.34601 S000001550YNK1YKL067WverifiedNucleoside diphosphate kinase, catalyzes the transfer of gammaphosphates from nucleoside triphosphates,usually ATP, to nucleoside diphosphates by amechanism that involves formation of anautophosphorylated enzyme intermediate 0.070610.3454&radic&radic&radic&radic&radic S000003393RTS3YGR161CuncharacterizedPutative component of the protein phosphatase type 2A complex 0.070550.3454&radic&radic&radic&radic&radic S000002979SCL1YGL011CverifiedAlpha subunit of the 20S core complex of the 26S proteasomeinvolved in the degradation of ubiquitinatedsubstrates; essential for growth; detected inthe mitochondria 0.070650.3454&radic&radic&radic S000005042RAS2YNL098CverifiedGTP-binding protein that regulates the nitrogen starvationresponse, sporulation, and filamentous growth;farnesylation and palmitoylation required foractivity and localization to plasma membrane;homolog of mammalian Ras proto-oncogenes 0.070480.34513&radic&radic S000004186PWP1YLR196WverifiedProtein with WD-40 repeats involved in rRNA processing;associates with trans-acting ribosomebiogenesis factors; similar to beta-transducinsuperfamily 0.07050.34513&radic&radic&radic S000001295BCY1YIL033CverifiedRegulatory subunit of the cyclic AMP-dependent protein kinase(PKA), a component of a signaling pathway thatcontrols a variety of cellular processes,including metabolism, cell cycle, stressresponse, stationary phase, and sporulation 0.070330.34385&radic&radic&radic S000001415RRD1YIL153WverifiedActivator of the phosphotyrosyl phosphatase activity of PP2A;regulates G1 phase progression, the G2/M phasetransition, microtubule dynamics, theosmoresponse, bud morphogenesis and DNA repair;subunit of the Tap42p-Sit4p-Rrd1p complex 0.070260.34385&radic&radic S000003143SAE2YGL175CverifiedProtein with a role in accurate meiotic and mitoticdouble-strand break repair; phosphorylated inresponse to DNA damage and required for normalresistance to DNA-damaging agents 0.070280.34385&radic&radic&radic S000006227EAF3YPR023CverifiedEsa1p-associated factor, nonessential component of the NuA4acetyltransferase complex, homologous toDrosophila dosage compensation protein MSL3 0.070430.34385&radic&radic S000005932TAF3YPL011CverifiedTFIID subunit (47 kDa), involved in promoter binding and RNApolymerase II transcription initiation 0.070190.34354&radic&radic&radic&radic&radic S000005540RTS1YOR014WverifiedB-type regulatory subunit of protein phosphatase 2A (PP2A);homolog of the mammalian B' subunit of PP2A &radic0.07020.34354&radic&radic&radic&radic S000006211REC8YPR007CverifiedMeiosis-specific component of sister chromatid cohesioncomplex; maintains cohesion between sisterchromatids during meiosis I; maintains cohesionbetween centromeres of sister chromatids untilmeiosis II; homolog of S. pombe Rec8p &radic0.069870.34275&radic&radic S000002871STP1YDR463WverifiedTranscription factor, activated by proteolytic processing inresponse to signals from the SPS sensor systemfor external amino acids; activatestranscription of amino acid permease genes andmay have a role in tRNA processing 0.069620.34178&radic S000005041PHO23YNL097CverifiedProbable component of the Rpd3 histone deacetylase complex,involved in transcriptional regulation of PHO5;C-terminus has similarity to human candidatetumor suppressor p33(ING1) 0.069690.34178&radic&radic&radic S000004652ERB1YMR049CverifiedProtein required for maturation of the 25S and 5.8S ribosomalRNAs; constituent of 66S pre-ribosomalparticles; homologous to mammalian Bop1 0.069660.34178&radic S000002794MUS81YDR386WverifiedHelix-hairpin-helix protein, involved in DNA repair andreplication fork stability; functions as anendonuclease in complex with Mms4p; interactswith Rad54p 0.069580.34178&radic&radic&radic&radic&radic S000002218TSR1YDL060WverifiedProtein required for processing of 20S pre-rRNA in thecytoplasm, associates with pre-40S ribosomalparticles 0.069470.34103&radic S000003234SWC4YGR002CverifiedProtein of unknown function, component of the Swr1p complexthat incorporates Htz1p into chromatin;component of the NuA4 histone acetyltransferasecomplex 0.069540.34103&radic&radic&radic S000007620YLR363W-AUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus 0.069450.34103&radic S000002700SRP101YDR292CverifiedSignal recognition particle (SRP) receptor - alpha subunit;contain GTPase domains; involved inSRP-dependent protein targeting; interacts withSRP102p 0.069520.34103&radic&radic&radic&radic&radic S000004853CUS1YMR240CverifiedProtein required for assembly of U2 snRNP into the spliceosome,forms a complex with Hsh49p and Hsh155p 0.069380.34059&radic&radic S000006386SMX3YPR182WverifiedCore Sm protein Sm F; part of heteroheptameric complex (withSmb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm F 0.069220.33989&radic&radic S000005111SKO1YNL167CverifiedBasic leucine zipper (bZIP) transcription factor of theATF/CREB family, forms a complex with Tup1p andSsn6p to both activate and represstranscription; cytosolic and nuclear proteininvolved in osmotic and oxidative stressresponses 0.069170.33989&radic&radic S000004645ARG80YMR042WverifiedTranscription factor involved in regulation ofarginine-responsive genes; acts with Arg81p andArg82p 0.069050.33957&radic&radic&radic S000004580CTK3YML112WverifiedGamma subunit of C-terminal domain kinase I (CTDK-I), whichphosphorylates the C-terminal repeated domainof the RNA polymerase II large subunit (Rpo21p)to affect both transcription and pre-mRNA 3'end processing 0.068950.3391&radic S000005609WHI5YOR083WverifiedRepressor of G1 transcription that binds to SCB binding factor(SBF) at SCB target promoters in early G1;phosphorylation of Whi5p by the CDK,Cln3p/Cdc28p relieves repression and promoterbinding by Whi5; periodically expressed in G1 0.068960.3391&radic&radic&radic&radic S000004255NEJ1YLR265CverifiedProtein involved in regulation of nonhomologous end joining;repressed by MAT heterozygosity; associateswith Lif1p and regulates its cellulardistribution 0.068980.3391&radic&radic&radic&radic&radic S000001887BLM10YFL007WverifiedProteosome activator subunit; found in association with coreparticles, with and without the 19S regulatoryparticle; required for resistance to bleomycin,may be involved in protecting against oxidativedamage; similar to mammalian PA200 0.068910.33882&radic&radic&radic S000001852YFL042CUncharacterizedPutative protein of unknown function; YFL042C is not an essential gene 0.06870.33826 S000003608PSF2YJL072CverifiedSubunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), whichis localized to DNA replication origins andimplicated in assembly of the DNA replicationmachinery &radic0.068680.33826&radic S000002367NHP2YDL208WverifiedNuclear protein related to mammalian high mobility group (HMG)proteins, essential for function of H/ACA-typesnoRNPs, which are involved in 18S rRNAprocessing 0.068550.33784&radic&radic&radic S000006134LEA1YPL213WverifiedComponent of U2 snRNP; disruption causes reduced U2 snRNPlevels; physically interacts with Msl1p;invovled in telomere maintenance; putativehomolog of human U2A' snRNP protein 0.068640.33784&radic&radic&radic&radic S000001209CDC23YHR166CverifiedSubunit of the anaphase-promoting complex/cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 0.068420.3373&radic S000005004ARP5YNL059CverifiedNuclear actin-related protein involved in chromatin remodeling,component of chromatin-remodeling enzymecomplexes 0.068470.3373&radic S000004223EST1YLR233CverifiedTLC1 RNA-associated factor involved in telomere lengthregulation as the recruitment subunit of thetelomerase holoenzyme, has a possible role inactivating Est2p-TLC1-RNA bound to the telomere 0.068360.3369&radic&radic&radic&radic S000006249MNI2YPR045CuncharacterizedDeletion mutant is synthetically lethal with MEN mutants 0.068280.33665&radic S000002359MGT1YDL200CverifiedDNA repair methyltransferase (6-O-methylguanine-DNA methylase)involved in protection against DNA alkylationdamage 0.068270.33665&radic S000001716RSC4YKR008WverifiedOne of 15 subunits of the 'Remodel the Structure of Chromatin'(RSC) complex; found in close proximity tonucleosomal DNA; displaced from the surface ofnucleosomal DNA after chromatin remodeling 0.068250.33665&radic&radic&radic&radic S000000781POL5YEL055CverifiedProtein with sequence similarity to the human MybBP1A and weaksequence similar to B-type DNA polymerases, notrequired for chromosomal DNA replication;required for the synthesis of rRNA 0.068140.33602&radic&radic S000001656SNU114YKL173WverifiedGTPase component of U5 snRNP involved in mRNA splicing viaspliceosome; binds directly to U5 snRNA;proposed to be involved in conformationalchanges of the spliceosome; similarity toribosomal translocation factor EF-2 0.068060.33575&radic&radic&radic&radic S000005869YOR342CUncharacterizedHypothetical protein 0.068030.33571&radic&radic&radic S000005398PRE6YOL038Wverified20S proteasome alpha-type subunit; green fluorescent protein(GFP)-fusion protein relocates from the cytosolto the mitochondrial outer surface uponoxidative stress 0.0680.33499&radic&radic&radic S000002347PPH22YDL188CverifiedCatalytic subunit of protein phosphatase 2A, functionallyredundant with Pph21p; methylated at Cterminus; forms alternate complexes withseveral regulatory subunits; involved in signaltransduction and regulation of mitosis &radic0.06780.33499&radic&radic&radic S000001643ELF1YKL160WverifiedTranscription elongation factor that contains a conserved zincfinger domain; implicated in the maintenance ofproper chromatin structure in activelytranscribed regions; deletion inhibits Bromemosaic virus (BMV) gene expression 0.067860.33499&radic&radic&radic&radic&radic&radic S000000776RML2YEL050CverifiedMitochondrial ribosomal protein of the large subunit, hassimilarity to E. coli L2 ribosomal protein;fat21 mutant allele causes inability to utilizeoleate and may interfere with activity of theAdr1p transcription factor 0.067850.33499&radic&radic&radic S000004642SUB1YMR039CverifiedTranscriptional coactivator, facilitates elongation byinfluencing enzymes that modify RNAP II, actsin a peroxide resistance pathway involvingRad2p; suppressor of TFIIB mutations 0.067520.33406&radic&radic&radic&radic&radic S000003844CSN12YJR084WverifiedSubunit of the Cop9 signalosome, which is required fordeneddylation, or removal of the ubiquitin-likeprotein Rub1p from Cdc53p (cullin); involved inadaptation to pheromone signaling 0.067380.33372&radic&radic&radic S000002771ESC2YDR363WverifiedProtein involved in mating-type locus silencing, interacts withSir2p; probably functions to recruit orstabilize Sir proteins 0.067320.33315&radic&radic&radic S000003065SRM1YGL097WverifiedNucleotide exchange factor for Gsp1p, localizes to the nucleus,required for nucleocytoplasmic trafficking ofmacromolecules; potentially phosphorylated byCdc28p &radic0.06710.33238&radic&radic&radic S000005420GPD2YOL059WverifiedNAD-dependent glycerol 3-phosphate dehydrogenase, homolog ofGpd1p, expression is controlled by anoxygen-independent signaling pathway requiredto regulate metabolism under anoxic conditions;located in cytosol and mitochondria 0.067180.33238&radic&radic&radic S000006394RPC82YPR190CverifiedRNA polymerase III subunit C82 0.067120.33238&radic S000001495PRP40YKL012WverifiedU1 snRNP protein involved in splicing, interacts with thebranchpoint-binding protein during theformation of the second commitment complex 0.066960.33171&radic&radic S000004346TAL1YLR354CverifiedTransaldolase, enzyme in the non-oxidative pentose phosphatepathway; converts sedoheptulose 7-phosphate andglyceraldehyde 3-phosphate to erythrose4-phosphate and fructose 6-phosphate 0.066790.33167&radic&radic&radic&radic&radic S000000064SWD1YAR003WverifiedSubunit of the COMPASS (Set1C) complex, which methylateshistone H3 on lysine 4 and is required intranscriptional silencing near telomeres; WD40beta propeller superfamily member withsimilarity to mammalian Rbbp7 0.066650.33101&radic&radic S000003162HOS2YGL194CverifiedHistone deacetylase required for gene activation via specificdeacetylation of lysines in H3 and H4 histonetails; subunit of the Set3 complex, ameiotic-specific repressor of sporulationspecific genes that contains deacetylaseactivity 0.066610.33085&radic&radic&radic&radic&radic&radic S000003011DST1YGL043WverifiedGeneral transcription elongation factor TFIIS, enables RNApolymerase II to read through blocks toelongation by stimulating cleavage of nascenttranscripts stalled at transcription arrestsites 0.06660.33058&radic&radic&radic&radic S000004836UBP8YMR223WverifiedUbiquitin-specific protease that is a component of the SAGA(Spt-Ada-Gcn5-Acetyltransferase) acetylationcomplex; required for SAGA-mediateddeubiquitination of histone H2B 0.066560.33038&radic&radic S000003663SPT10YJL127CverifiedPutative histone acetylase, sequence-specific activator ofhistone genes, binds specifically and highlycooperatively to pairs of UAS elements in corehistone promoters, functions at or near theTATA box 0.066030.32843&radic&radic&radic&radic S000001107RRP3YHR065CverifiedProtein involved in rRNA processing; required for maturation ofthe 35S primary transcript of pre-rRNA and forcleavage leading to mature 18S rRNA; homologousto eIF-4a, which is a DEAD box RNA-dependentATPase with helicase activity 0.065980.32843&radic&radic&radic&radic&radic S000001411MLP2YIL149CverifiedMyosin-like protein associated with the nuclear envelope,connects the nuclear pore complex with thenuclear interior; involved in the Tel1p pathwaythat controls telomere length 0.066040.32843&radic&radic S000006434LSM3YLR438C-AverifiedLsm (Like Sm) protein; part of heteroheptameric complexes(Lsm2p-7p and either Lsm1p or 8p): cytoplasmicLsm1p complex involved in mRNA decay; nuclearLsm8p complex part of U6 snRNP and possiblyinvolved in processing tRNA, snoRNA, and rRNA 0.066010.32843&radic S000001056SPO13YHR014WverifiedMeiosis-specific protein, involved in maintaining sisterchromatid cohesion during meiosis I as well aspromoting proper attachment of kinetochores tothe spindle during meiosis I and meiosis II &radic0.065920.32826&radic&radic&radic S000005795PAC1YOR269WverifiedProtein involved in nuclear migration, part of thedynein/dynactin pathway; targets dynein tomicrotubule tips, which is necessary forsliding of microtubules along bud cortex;synthetic lethal with bni1; homolog of humanLIS1 0.065470.3263&radic&radic S000001052RPL27AYHR010WverifiedProtein component of the large (60S) ribosomal subunit, nearlyidentical to Rpl27Bp and has similarity to ratL27 ribosomal protein 0.065720.3263&radic&radic&radic&radic S000002897SLD5YDR489WverifiedSubunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), whichis localized to DNA replication origins andimplicated in assembly of the DNA replicationmachinery &radic0.065330.32601 S000004924GAS1YMR307WverifiedBeta-1.3-glucanosyltransferase, required for cell wallassembly; localizes to the cell surface via aglycosylphosphatidylinositol (GPI) anchor 0.065430.32601&radic&radic&radic&radic S000005775APC5YOR249CverifiedSubunit of the Anaphase-Promoting Complex/Cyclosome (APC/C),which is a ubiquitin-protein ligase requiredfor degradation of anaphase inhibitors,including mitotic cyclins, during themetaphase/anaphase transition 0.065150.32533&radic&radic&radic S000003949HSP104YLL026WverifiedHeat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p(Hsp70) to refold and reactivate previouslydenatured, aggregated proteins; responsive tostresses including: heat, ethanol, and sodiumarsenite; involved in [PSI+] propagation 0.065130.3251&radic&radic&radic&radic S000002827RAD30YDR419WverifiedDNA polymerase eta, involved in the predominantly error-freebypass replication of DNA lesions, catalyzesthe efficient and accurate synthesis of DNAopposite cyclobutane pyrimidine dimers; homologof human POLH and bacterial DinB proteins &radic0.065080.32507&radic&radic&radic S000004466YAP1YML007WverifiedBasic leucine zipper (bZIP) transcription factor required foroxidative stress tolerance; mediatespleiotropic drug and metal resistance;localized to the nucleus in response to thepresence of oxidants 0.065010.32484&radic&radic&radic&radic&radic&radic S000001756NAP1YKR048CverifiedProtein that interacts with mitotic cyclin Clb2p; required forthe regulation of microtubule dynamics duringmitosis; controls bud morphogenesis; involvedin the transport of H2A and H2B histones to thenucleus 0.064860.3241&radic&radic&radic S000002802RPT3YDR394WverifiedOne of six ATPases of the 19S regulatory particle of the 26Sproteasome involved in the degradation ofubiquitinated substrates; substrate ofN-acetyltransferase B 0.064990.3241&radic&radic&radic&radic&radic&radic S000005054NOP15YNL110CverifiedConstituent of 66S pre-ribosomal particles, involved in 60Sribosomal subunit biogenesis; localizes to bothnucleolus and cytoplasm 0.064730.32355&radic&radic S000001557MUD2YKL074CverifiedProtein involved in early pre-mRNA splicing; component of thepre-mRNA-U1 snRNP complex, the commitmentcomplex; interacts with Msl5p/BBP splicingfactor and Sub2p; similar to metazoan splicingfactor U2AF65 0.064710.32355&radic&radic&radic&radic&radic S000003796RAD26YJR035WverifiedProtein involved in transcription-coupled repair nucleotideexcision repair of UV-induced DNA lesions;homolog of human CSB protein 0.064570.32303&radic&radic S000004368PSY3YLR376CuncharacterizedProtein of unknown function; deletion results in a mutatorphenotype suggesting a role for this protein asa mutational suppressor; deletion increasessensitivity to anticancer drugs oxaliplatin andcisplatin but not mitomycin C 0.064390.32189&radic&radic S000005508SPT20YOL148CverifiedSubunit of the SAGA transcriptional regulatory complex,involved in maintaining the integrity of thecomplex 0.064130.32106&radic&radic&radic S000000831SMB1YER029CverifiedCore Sm protein Sm B; part of heteroheptameric complex (withSmd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)that is part of the spliceosomal U1, U2, U4,and U5 snRNPs; homolog of human Sm B and Sm B' 0.064120.32106&radic&radic S000005425MET22YOL064CverifiedBisphosphate-3'-nucleotidase, involved in salt tolerance andmethionine biogenesis; dephosphorylates3'-phosphoadenosine-5'-phosphate and3'-phosphoadenosine-5'-phosphosulfate,intermediates of the sulfate assimilationpathway 0.064050.32064&radic&radic S000001894SPB4YFL002CverifiedPutative ATP-dependent RNA helicase, nucleolar protein requiredfor synthesis of 60S ribosomal subunits at alate step in the pathway; sediments with 66Spre-ribosomes in sucrose gradients 0.064050.32064&radic&radic&radic S000000517GBP2YCL011CverifiedPoly(A+) RNA-binding protein, involved in the export of mRNAsfrom the nucleus to the cytoplasm; similar toHrb1p and Npl3p; also binds single-strandedtelomeric repeat sequence in vitro 0.064030.32064&radic&radic&radic S000000457SRB6YBR253WverifiedEssentital subunit of the RNA polymerase II mediator complex;associates with core polymerase subunits toform the RNA polymerase II holoenzyme;essential for transcriptional regulation 0.063970.32044&radic&radic&radic&radic&radic S000002805NCB2YDR397CverifiedBeta subunit of the NC2 dimeric histone-fold complex; repressesRNA polymerase II transcription through bindingto TBP and inhibition of TFIIA and TFIIB;homologous to the Dr1 subunit of the mammalianNC2 (negative cofactor2) 0.063850.31969&radic&radic&radic&radic&radic S000005558HMS1YOR032CverifiedBasic helix-loop-helix (bHLH) protein with similarity tomyc-family transcription factors;overexpression confers hyperfilamentous growthand suppresses the pseudohyphal filamentationdefect of a diploid mep1 mep2 homozygous nullmutant 0.063860.31969&radic&radic&radic S000002865TOM1YDR457WverifiedE3 ubiquitin ligase of the hect-domain class; has a role inmRNA export from the nucleus and may regulatetranscriptional coactivators 0.06370.31913&radic S000003206HAP2YGL237CverifiedSubunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5pCCAAT-binding complex, a transcriptionalactivator and global regulator of respiratorygene expression; contains sequences sufficientfor both complex assembly and DNA binding 0.063550.31836&radic&radic S000004777MLH1YMR167WverifiedProtein required for mismatch repair in mitosis and meiosis,postmeiotic segregation, and spore viability;forms a complex with Pms1p and Msh2p to repairmismatched DNA; human homolog is associatedwith hereditary non-polyposis colon cancer 0.06340.31774&radic&radic&radic&radic S000005361PHO80YOL001WverifiedCyclin, negatively regulates phosphate metabolism;Pho80p-Pho85p (cyclin-CDK complex)phosphorylates Pho4p and Swi5p; deletion ofPHO80 leads to aminoglycoside supersensitivity;truncated form of PHO80 affects vacuoleinheritance 0.063350.31723&radic&radic&radic&radic S000006348NOC4YPR144CverifiedNucleolar protein, forms a complex with Nop14p that mediatesmaturation and nuclear export of 40S ribosomalsubunits 0.063270.31723&radic&radic&radic&radic S000007235SEM1YDR363W-AverifiedComponent of the lid subcomplex of the regulatory subunit ofthe 26S proteasome; ortholog of human DSS1 0.063240.31675&radic S000004244NDL1YLR254Cuncharacterizedhomolog of nuclear distribution factor NudE, NUDEL 0.063160.31657&radic&radic&radic&radic S000001880HSP12YFL014WverifiedPlasma membrane localized protein that protects membranes fromdesiccation; induced by heat shock, oxidativestress, osmostress, stationary phase entry,glucose depletion, oleate and alcohol;regulated by the HOG and Ras-Pka pathways 0.063010.3159&radic&radic S000001613SHE2YKL130CverifiedRNA-binding protein that binds specific mRNAs and interactswith She3p; part of the mRNA localizationmachinery that restricts accumulation ofcertain proteins to the bud 0.063070.3159&radic&radic&radic S000002495SLU7YDR088CverifiedRNA splicing factor, required for ATP-independent portion of2nd catalytic step of spliceosomal RNAsplicing; interacts with Prp18p; contains zincknuckle domain 0.06290.31529&radic&radic&radic&radic&radic S000002583NGG1YDR176WverifiedTranscriptional regulator involved in glucose repression ofGal4p-regulated genes; component oftranscriptional adaptor and histoneacetyltransferase complexes, the ADA complex,the SAGA complex, and the SLIK complex 0.06290.31529&radic&radic&radic S000004416SPP382YLR424WverifiedEssential protein that forms a dimer with Ntr2p; also forms atrimer, with Ntr2p and Prp43p, that is involvedin spliceosome disassembly; found also in amultisubunit complex with the splicing factorClf1p; suppressor of prp38-1 mutation 0.062760.31382&radic&radic S000001881IES1YFL013CverifiedSubunit of the INO80 chromatin remodeling complex 0.062790.31382&radic&radic S000004261YLR271WUncharacterizedPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YLR271W is not an essential gene 0.062790.31382&radic&radic&radic&radic&radic S000006124TPK2YPL203WverifiedSubunit of cytoplasmic cAMP-dependent protein kinase, whichcontains redundant catalytic subunits Tpk1p,Tpk2p, and Tpk3p and regulatory subunit Bcy1p;promotes vegetative growth in response tonutrients; activates filamentous growth 0.062710.31382&radic&radic&radic&radic&radic S000001221STB5YHR178WverifiedActivator of multidrug resistance genes, forms a heterodimerwith Pdr1p; contains a Zn(II)2Cys6 zinc fingerdomain that interacts with a PDRE (pleotropicdrug resistance element) in vitro; binds Sin3pin a two-hybrid assay 0.062330.31195&radic&radic&radic&radic S000000967PAB1YER165WverifiedPoly(A) binding protein, part of the 3'-end RNA-processingcomplex, mediates interactions between the 5'cap structure and the 3' mRNA poly(A) tail,involved in control of poly(A) tail length,interacts with translation factor eIF-4G 0.062550.31195&radic&radic S000005192RPA49YNL248CverifiedRNA polymerase I subunit A49 0.062310.31173&radic S000001222OYE2YHR179WverifiedWidely conserved NADPH oxidoreductase containing flavinmononucleotide (FMN), homologous to Oye3p withslight differences in ligand binding andcatalytic properties; may be involved in sterolmetabolism 0.062270.31149&radic&radic&radic&radic S000003090NAB2YGL122CverifiedNuclear polyadenylated RNA-binding protein; autoregulates mRNAlevels; related to human hnRNPs; has nuclearlocalization signal sequence that binds toKap104p; required for poly(A) tail lengthcontrol and nuclear mRNA export 0.062230.31137&radic&radic&radic S000003279TFC4YGR047CverifiedOne of six subunits of the RNA polymerase III transcriptioninitiation factor complex (TFIIIC); part of theTauA domain of TFIIIC that binds BoxA DNApromoter sites of tRNA and similar genes; hasTPR motifs; human homolog is TFIIIC-102 0.062150.31128&radic&radic&radic S000005019IMP4YNL075WverifiedComponent of the SSU processome, which is required for pre-18SrRNA processing; interacts with Mpp10p; memberof a superfamily of proteins that contain asigma(70)-like motif and associate with RNAs 0.062020.3106&radic&radic S000002198NAT1YDL040CverifiedSubunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p,Nat5p); N-terminally acetylates many proteins,which influences multiple processes such as thecell cycle, heat-shock resistance, mating,sporulation, and telomeric silencing 0.062110.3106&radic&radic S000005683PUP1YOR157CverifiedEndopeptidase with trypsin-like activity that cleaves afterbasic residues; beta-type subunit of 20Sproteasome synthesized as a proprotein beforebeing proteolytically processed for assemblyinto 20S particle; human homolog is subunit Z 0.061660.30917&radic&radic&radic&radic S000002890CWC21YDR482CverifiedComponent of a complex containing Cef1p, putatively involved inpre-mRNA splicing; may bind RNA; has similarityto S. pombe Cwf21p 0.061670.30917&radic&radic S000000340MEC1YBR136WverifiedGenome integrity checkpoint protein and PI kinase superfamilymember; signal transducer required for cellcycle arrest and transcriptional responsesprompted by damaged or unreplicated DNA;monitors and participates in meioticrecombination 0.061670.30917 S000003465PHO81YGR233CverifiedCyclin-dependent kinase (CDK) inhibitor, regulatesPho80p-Pho85p and Pcl7p-Pho85p cyclin-CDKcomplexes in response to phosphate levels;required for derepression of PHO5;transcriptionally regulated by Pho4p and Pho2p 0.061450.30787&radic&radic&radic&radic S000006125HRR25YPL204WverifiedProtein kinase involved in regulating diverse events includingvesicular trafficking, gene expression, DNArepair, and chromosome segregation; binds theCTD of RNA pol II; homolog of mammalian caseinkinase 1delta (CK1delta) 0.061420.30787&radic&radic&radic&radic&radic S000005735NPT1YOR209CverifiedNicotinate phosphoribosyltransferase, acts in the salvagepathway of NAD+ biosynthesis; required forsilencing at rDNA and telomeres and has a rolein silencing at mating-type loci; localized tothe nucleus 0.061280.30708&radic&radic&radic S000003490RAD2YGR258CverifiedSingle-stranded DNA endonuclease, cleaves single-stranded DNAduring nucleotide excision repair to excisedamaged DNA; subunit of Nucleotide ExcisionRepair Factor 3 (NEF3); homolog of human XPGprotein 0.061090.30704&radic